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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR89 Gene

protein-coding   GIFtS: 42
GCID: GC14M064063

WD Repeat Domain 89


(Previous symbol: C14orf150)
  Search for WDR89
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 891 2
C14orf1501 2 3
WD Repeat-Containing Protein 892

External Ids:    HGNC: 204891   Entrez Gene: 1128402   Ensembl: ENSG000001400067   UniProtKB: Q96FK63   

Export aliases for WDR89 gene to outside databases

Previous GC identifers: GC14M063135 GC14M044230


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR89 Gene: 
WDR89 (WD repeat domain 89) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR89 gene promoter:
         N-Myc   CBF-B   CP1A   NF-Y   CBF-C   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR89 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR89

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR89


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.2

WDR89 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR89 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M064063:  view genomic region     (about GC identifiers)

Start:
64,063,757 bp from pter      End:
64,108,591 bp from pter
Size:
44,835 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR89_HUMAN, Q96FK6 (See protein sequence)
Recommended Name: WD repeat-containing protein 89  
Size: 387 amino acids; 43215 Da

Explore the universe of human proteins at neXtProt for WDR89: NX_Q96FK6

Explore proteomics data for WDR89 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96FK6

  • WDR89 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR89 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001008726.1  NP_001245201.1  NP_542397.1  

    ENSEMBL proteins: 
     ENSP00000378399   ENSP00000267522   ENSP00000451702  

    Human Recombinant Protein Products for WDR89: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96FK6

    ProtoNet protein and cluster: Q96FK6

    UniProtKB/Swiss-Prot: WDR89_HUMAN, Q96FK6
    Similarity: Contains 6 WD repeats


    WDR89 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR89 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidWDR89 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR89

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/9 Interacting proteins for WDR89 (Q96FK63 ENSP000002675224) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PHYHIPQ925613I2D: score=4 
    POLR3FQ9H1D93I2D: score=4 
    MYZAPP0CAP13I2D: score=3 
    POLR2MP0CAP23I2D: score=3 
    GLI2P100703I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR89

    Search CenterWatch for drugs/clinical trials and news about WDR89

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR89 gene (3 alternative transcripts): 
    NM_001008726.2  NM_001258272.1  NM_080666.3  

    Unigene Clusters for WDR89:

    WD repeat domain 89
    Hs.655666  [show with all ESTs], Hs.741323  [show with all ESTs]
    Unigene Representative Sequences: NM_001258272, BC010698
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394942(uc001xgh.3 uc001xgi.3) ENST00000267522 ENST00000554717

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR89:
    hsa-miR-3163 hsa-miR-627 hsa-miR-29a* hsa-miR-545 hsa-miR-590-3p hsa-miR-497* hsa-miR-138-2* hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidWDR89 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WDR89
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR89
    Clone
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    OriGene clones in human, mouse for WDR89 (see all 13)
    OriGene ORF clones in mouse, rat for WDR89
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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR89 (NM_001008726)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR89
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR89
    Sirion Biotech Customized lentivirus for stable overexpression of WDR89 
                         Customized lentivirus expression plasmids for stable overexpression of WDR89 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR89

    Additional mRNA sequence: 

    AF115513.1 AK095324.1 BC010698.1 BX248008.1 

    5 DOTS entries:

    DT.40109688  DT.112187  DT.100021860  DT.100731932  DT.102826390 

    24/86 AceView cDNA sequences (see all 86):

    BI712118 BX248008 BC010698 BF939125 AK095324 R17617 F12991 AA587774 
    CR590052 BM725411 F10586 AI806289 BE219560 BM455141 AW873519 AA318958 
    BI713072 NM_080666 N39428 AF115513 BM984705 CR620350 BM455157 AW270921 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR89 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACTCTT
    WDR89 Expression
    About this image


    See WDR89 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR89

    SOURCE GeneReport for Unigene clusters: Hs.655666 Hs.741323
        SABiosciences Custom PCR Arrays for WDR89
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR89
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR89

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR89 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr891 , 5 WD repeat domain 891, 5 81.26(n)1
    81.09(a)1
      12 (32.89 cM)5
    723381  NM_028203.11  NP_082479.11 
     756305945 
    chicken
    (Gallus gallus)
    Aves WDR891 WD repeat domain 89 67.1(n)
    63.64(a)
      423510  XM_421411.3  XP_421411.2 
    lizard
    (Anolis carolinensis)
    Reptilia WDR896
    Uncharacterized protein
    63(a)
    1 ↔ 1
    1(2185321-2186469)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.171372 Xenopus laevis transcribed sequence with weak similarity more 72.83(n)    CA980975.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001482811 novel protein similar to H.sapiens WDR89, WD repeat more 53.24(n)
    43.78(a)
      100148281  NM_001167958.1  NP_001161430.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG121341 CG12134 44.52(n)
    33.22(a)
      36038  NM_136698.2  NP_610542.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YNL035C)4
    YNL035C1
    Putative protein of unknown function with similarity more4
    hypothetical protein1
    42.39(n)1
    34.95(a)1
      14(569691-568522)4
    8556951, 4  NP_014363.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G477901 transducin/WD-40 repeat-containing protein 47.55(n)
    32.97(a)
      819391  NM_130346.4  NP_566111.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g02941001 hypothetical protein 48.3(n)
    32.34(a)
      4352026  NM_001073143.1  NP_001066611.1 


    ENSEMBL Gene Tree for WDR89 (if available)
    TreeFam Gene Tree for WDR89 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR89 gene

    WDR89 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WDR89
    PGOHUM00000234867


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1078 SNPs in WDR89 are shown (see all 1078)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106022201,2
    C--44250507(+) ttttt-/T/TT  
            
    gagac
    3 -- int11NA 2
    rs1165585781,2
    F--64063269(+) ACAGCC/TTGACT 3 -- int12Minor allele frequency- T:0.02WA NA 238
    rs1178931541,2
    C,F--64063429(+) TATTTG/CCTGCA 3 -- int11Minor allele frequency- C:0.08NA 120
    rs1385920301,2
    C--64063432(+) TTGCTG/TCATGA 3 -- int10--------
    rs1863688261,2
    --64063496(+) GGCATC/TGATCC 3 -- int10--------
    rs1439811901,2
    C--64063611(+) TGAAAC/TTTCAC 3 -- int10--------
    rs560808291,2
    C,F--64063689(+) AAAGAT/CTGAAG 3 -- int13Minor allele frequency- C:0.07WA CSA 122
    rs765742171,2
    F--64063691(+) AGATTG/AAAGTT 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1909157921,2
    --64063729(+) TTCACA/GCTCTA 3 -- int10--------
    rs1473010711,2
    --64063841(+) GGAACA/GCAAAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR89 (64063757 - 64108591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR89:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677727CNV Deletion23128226
    dgv137n21CNV Gain19592680
    nsv528691CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR89 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with WDR89)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112840 HGNC: 20489 AceView: C14orf150 Ensembl:ENSG00000140006 euGenes: HUgn112840
    ECgene: WDR89 H-InvDB: WDR89

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR89 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR89 gene:
    Search GeneIP for patents involving WDR89

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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