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Aliases for WDR89 Gene

Aliases for WDR89 Gene

  • WD Repeat Domain 89 2 3 5
  • C14orf150 3 4
  • MSTP050 3

External Ids for WDR89 Gene

Previous HGNC Symbols for WDR89 Gene

  • C14orf150

Previous GeneCards Identifiers for WDR89 Gene

  • GC14M063135
  • GC14M064063
  • GC14M044230

Summaries for WDR89 Gene

GeneCards Summary for WDR89 Gene

WDR89 (WD Repeat Domain 89) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR89 Gene

Genomics for WDR89 Gene

Regulatory Elements for WDR89 Gene

Enhancers for WDR89 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR89 on UCSC Golden Path with GeneCards custom track

Promoters for WDR89 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR89 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR89 Gene

Chromosome:
14
Start:
63,597,039 bp from pter
End:
63,641,923 bp from pter
Size:
44,885 bases
Orientation:
Minus strand

Genomic View for WDR89 Gene

Genes around WDR89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR89 Gene

Proteins for WDR89 Gene

  • Protein details for WDR89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FK6-WDR89_HUMAN
    Recommended name:
    WD repeat-containing protein 89
    Protein Accession:
    Q96FK6

    Protein attributes for WDR89 Gene

    Size:
    387 amino acids
    Molecular mass:
    43215 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR89 Gene

Proteomics data for WDR89 Gene at MOPED

Post-translational modifications for WDR89 Gene

  • Ubiquitination at Lys 95
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR89 Gene

No data available for DME Specific Peptides for WDR89 Gene

Domains & Families for WDR89 Gene

Gene Families for WDR89 Gene

Protein Domains for WDR89 Gene

Suggested Antigen Peptide Sequences for WDR89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FK6

UniProtKB/Swiss-Prot:

WDR89_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR89: view

Function for WDR89 Gene

genes like me logo Genes that share phenotypes with WDR89: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR89 Gene

Localization for WDR89 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR89 Gene COMPARTMENTS Subcellular localization image for WDR89 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR89 Gene

Pathways & Interactions for WDR89 Gene

SuperPathways for WDR89 Gene

No Data Available

Interacting Proteins for WDR89 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000267522%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000381034%0d%0a9606.ENSP00000341327%0d%0a9606.ENSP00000366828%0d%0a
Selected Interacting proteins: ENSP00000267522 Q96FK6-WDR89_HUMAN for WDR89 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for WDR89 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR89 Gene

Drugs & Compounds for WDR89 Gene

No Compound Related Data Available

Transcripts for WDR89 Gene

Unigene Clusters for WDR89 Gene

WD repeat domain 89:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR89 Gene

No ASD Table

Relevant External Links for WDR89 Gene

GeneLoc Exon Structure for
WDR89
ECgene alternative splicing isoforms for
WDR89

Expression for WDR89 Gene

mRNA expression in normal human tissues for WDR89 Gene

Protein differential expression in normal tissues from HIPED for WDR89 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.5), Lung (16.8), and CD4 Tcells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR89 Gene



SOURCE GeneReport for Unigene cluster for WDR89 Gene Hs.655666

genes like me logo Genes that share expression patterns with WDR89: view

Protein tissue co-expression partners for WDR89 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR89 Gene

Orthologs for WDR89 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR89 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR89 35
  • 88.43 (n)
  • 86.01 (a)
WDR89 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR89 35
  • 89.75 (n)
  • 86.82 (a)
WDR89 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr89 35
  • 81.26 (n)
  • 81.09 (a)
Wdr89 16
Wdr89 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR89 35
  • 99.48 (n)
  • 99.22 (a)
WDR89 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr89 35
  • 82.04 (n)
  • 81.87 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR89 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR89 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR89 35
  • 67.1 (n)
  • 63.64 (a)
WDR89 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR89 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16071 35
wdr89 35
  • 66.4 (n)
  • 56.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17137 35
zebrafish
(Danio rerio)
Actinopterygii wdr89 35
  • 53.24 (n)
  • 43.78 (a)
WDR89 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005524 35
  • 42.26 (n)
  • 33.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12134 35
  • 44.01 (n)
  • 33.33 (a)
CG12134 36
  • 24 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL218C 35
  • 40 (n)
  • 31.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08449g 35
  • 47.13 (n)
  • 33.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL035C 35
  • 42.69 (n)
  • 36.95 (a)
-- 36
  • 25 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G47790 35
  • 48.27 (n)
  • 33.69 (a)
rice
(Oryza sativa)
Liliopsida Os12g0294100 35
  • 47.67 (n)
  • 33.52 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02570 35
  • 41.93 (n)
  • 34.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC63.06 35
  • 43.76 (n)
  • 27.89 (a)
Species with no ortholog for WDR89:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR89 Gene

ENSEMBL:
Gene Tree for WDR89 (if available)
TreeFam:
Gene Tree for WDR89 (if available)

Paralogs for WDR89 Gene

Pseudogenes.org Pseudogenes for WDR89 Gene

genes like me logo Genes that share paralogs with WDR89: view

No data available for Paralogs for WDR89 Gene

Variants for WDR89 Gene

Sequence variations from dbSNP and Humsavar for WDR89 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1272711 -- 63,602,219(-) gggat(A/T)acagg intron-variant
rs1273314 -- 63,623,699(-) tgaga(A/C)agagt intron-variant
rs7141095 -- 63,604,041(+) tcacc(A/T)gccca intron-variant, upstream-variant-2KB
rs7142943 -- 63,602,248(+) ggcag(C/G)gatca intron-variant
rs1626644 -- 63,613,190(-) GCAGA(A/T)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR89 Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV Gain 19592680
nsv528691 CNV Gain 19592680
esv2677727 CNV Deletion 23128226

Variation tolerance for WDR89 Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR89 Gene

Disorders for WDR89 Gene

Relevant External Links for WDR89

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR89

No disorders were found for WDR89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR89 Gene

Publications for WDR89 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for WDR89 Gene

Sources for WDR89 Gene

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