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Aliases for WDR88 Gene

Aliases for WDR88 Gene

  • WD Repeat Domain 88 2 3 5
  • PQQ Repeat And WD Repeat-Containing Protein 3 4
  • PQQ Repeat And WD Repeat Domain Containing 2 3
  • PQWD 3 4

External Ids for WDR88 Gene

Previous HGNC Symbols for WDR88 Gene

  • PQWD

Previous GeneCards Identifiers for WDR88 Gene

  • GC19P038316
  • GC19P033622
  • GC19P030125

Summaries for WDR88 Gene

GeneCards Summary for WDR88 Gene

WDR88 (WD Repeat Domain 88) is a Protein Coding gene. An important paralog of this gene is WDR5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR88 Gene

Genomics for WDR88 Gene

Regulatory Elements for WDR88 Gene

Enhancers for WDR88 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR88 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR88 Gene

33,132,029 bp from pter
33,175,799 bp from pter
43,771 bases
Plus strand

Genomic View for WDR88 Gene

Genes around WDR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR88 Gene

Proteins for WDR88 Gene

  • Protein details for WDR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 88
    Protein Accession:
    Secondary Accessions:
    • Q8NEF8

    Protein attributes for WDR88 Gene

    472 amino acids
    Molecular mass:
    52621 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31227.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR88 Gene


neXtProt entry for WDR88 Gene

Proteomics data for WDR88 Gene at MOPED

Post-translational modifications for WDR88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR88 Gene

Domains & Families for WDR88 Gene

Gene Families for WDR88 Gene

Suggested Antigen Peptide Sequences for WDR88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 WD repeats.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR88: view

Function for WDR88 Gene

Phenotypes for WDR88 Gene

genes like me logo Genes that share phenotypes with WDR88: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR88 Gene

Localization for WDR88 Gene

Subcellular locations from

Jensen Localization Image for WDR88 Gene COMPARTMENTS Subcellular localization image for WDR88 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR88 Gene

Pathways & Interactions for WDR88 Gene

SuperPathways for WDR88 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR88 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR88 Gene

Drugs & Compounds for WDR88 Gene

No Compound Related Data Available

Transcripts for WDR88 Gene

mRNA/cDNA for WDR88 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR88 Gene

WD repeat domain 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR88 Gene

No ASD Table

Relevant External Links for WDR88 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR88 Gene

mRNA expression in normal human tissues for WDR88 Gene

mRNA differential expression in normal tissues according to GTEx for WDR88 Gene

This gene is overexpressed in Testis (x20.1).

Protein differential expression in normal tissues from HIPED for WDR88 Gene

This gene is overexpressed in Skin (61.5) and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR88 Gene

SOURCE GeneReport for Unigene cluster for WDR88 Gene Hs.211046

genes like me logo Genes that share expression patterns with WDR88: view

Protein tissue co-expression partners for WDR88 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR88 Gene

Orthologs for WDR88 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR88 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR88 35
  • 81.57 (n)
  • 73.85 (a)
WDR88 36
  • 67 (a)
(Canis familiaris)
Mammalia WDR88 35
  • 79.5 (n)
  • 71.75 (a)
WDR88 36
  • 66 (a)
(Mus musculus)
Mammalia Wdr88 35
  • 74.65 (n)
  • 67.74 (a)
Wdr88 16
(Pan troglodytes)
Mammalia WDR88 35
  • 99.15 (n)
  • 98.73 (a)
WDR88 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr88 35
  • 76.95 (n)
  • 69.14 (a)
(Monodelphis domestica)
Mammalia WDR88 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia WDR88 36
  • 55 (a)
(Gallus gallus)
Aves WDR88 35
  • 62.96 (n)
  • 55.82 (a)
(Anolis carolinensis)
Reptilia WDR88 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr88 35
  • 58.68 (n)
  • 48.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUP1 36
  • 14 (a)
Species with no ortholog for WDR88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR88 Gene

Gene Tree for WDR88 (if available)
Gene Tree for WDR88 (if available)

Paralogs for WDR88 Gene

Paralogs for WDR88 Gene

(7) SIMAP similar genes for WDR88 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR88: view

Variants for WDR88 Gene

Sequence variations from dbSNP and Humsavar for WDR88 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11881580 - 33,156,473(+) GAAAC(C/T)GTGGA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
VAR_035892 A breast cancer sample
rs7257721 -- 33,172,887(+) gagtt(C/T)gagac intron-variant
rs7259506 -- 33,143,865(+) TATGT(A/G)CTCAC intron-variant
rs12977459 -- 33,146,043(+) GGAAA(A/C)CAGCt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR88 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
esv2657217 CNV Deletion 23128226
esv2677868 CNV Deletion 23128226
esv2718468 CNV Deletion 23290073
nsv828525 CNV Loss 20364138

Variation tolerance for WDR88 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR88 Gene

Disorders for WDR88 Gene

Relevant External Links for WDR88

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR88 Gene

Publications for WDR88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for WDR88 Gene

Sources for WDR88 Gene