Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR88 Gene

Aliases for WDR88 Gene

  • WD Repeat Domain 88 2 3 5
  • PQQ Repeat And WD Repeat-Containing Protein 3 4
  • PQQ Repeat And WD Repeat Domain Containing 2 3
  • PQWD 3 4
  • WD Repeat-Containing Protein 88 3

External Ids for WDR88 Gene

Previous HGNC Symbols for WDR88 Gene

  • PQWD

Previous GeneCards Identifiers for WDR88 Gene

  • GC19P038316
  • GC19P033622
  • GC19P030125

Summaries for WDR88 Gene

GeneCards Summary for WDR88 Gene

WDR88 (WD Repeat Domain 88) is a Protein Coding gene. An important paralog of this gene is WDSUB1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR88 Gene

Genomics for WDR88 Gene

Regulatory Elements for WDR88 Gene

Enhancers for WDR88 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G033175 1.6 FANTOM5 ENCODE 26.6 +45.1 45112 2.7 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 GPATCH1 LSM14A WDR88 SLC7A10 PDCD5 RGS9BP LRP3 TRT-AGT1-3
GH19G033160 1 Ensembl ENCODE 23.9 +28.8 28785 1.5 PKNOX1 MAX ZBTB40 ZFHX2 IKZF2 RFX1 ZNF571 L3MBTL2 ZNF560 GABPA WDR88 GPATCH1 PDCD5 GC19M033175
GH19G033173 0.5 FANTOM5 36.1 +41.7 41719 0.0 ZFHX2 THRB EGR2 WDR88 GC19M033175
GH19G033100 1.3 ENCODE dbSUPER 12.7 -30.9 -30944 1.9 HDGF PKNOX1 FOXA2 ATF1 ARNT SIN3A TCF12 ZNF766 GATA2 FOS RHPN2 WDR88 GPATCH1
GH19G033183 1.2 Ensembl ENCODE 12.5 +52.1 52050 1.0 HDAC1 HDGF TBP RB1 SREBF2 ZNF76 KLF17 FEZF1 ZNF2 RAD21 WDR88 ENSG00000267054 ENSG00000273420
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR88 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR88 Gene

Chromosome:
19
Start:
33,132,029 bp from pter
End:
33,175,799 bp from pter
Size:
43,771 bases
Orientation:
Plus strand

Genomic View for WDR88 Gene

Genes around WDR88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR88 Gene

Proteins for WDR88 Gene

  • Protein details for WDR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMY6-WDR88_HUMAN
    Recommended name:
    WD repeat-containing protein 88
    Protein Accession:
    Q6ZMY6
    Secondary Accessions:
    • Q8NEF8

    Protein attributes for WDR88 Gene

    Size:
    472 amino acids
    Molecular mass:
    52621 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31227.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR88 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR88 Gene

Post-translational modifications for WDR88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR88 Gene

No data available for DME Specific Peptides for WDR88 Gene

Domains & Families for WDR88 Gene

Gene Families for WDR88 Gene

Suggested Antigen Peptide Sequences for WDR88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR88: view

No data available for UniProtKB/Swiss-Prot for WDR88 Gene

Function for WDR88 Gene

Phenotypes for WDR88 Gene

genes like me logo Genes that share phenotypes with WDR88: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR88 Gene

Localization for WDR88 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR88 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR88 Gene

Pathways & Interactions for WDR88 Gene

SuperPathways for WDR88 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR88 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR88 Gene

Drugs & Compounds for WDR88 Gene

No Compound Related Data Available

Transcripts for WDR88 Gene

mRNA/cDNA for WDR88 Gene

(9) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR88 Gene

WD repeat domain 88:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR88 Gene

No ASD Table

Relevant External Links for WDR88 Gene

GeneLoc Exon Structure for
WDR88
ECgene alternative splicing isoforms for
WDR88

Expression for WDR88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR88 Gene

mRNA differential expression in normal tissues according to GTEx for WDR88 Gene

This gene is overexpressed in Testis (x20.1).

Protein differential expression in normal tissues from HIPED for WDR88 Gene

This gene is overexpressed in Skin (61.5) and Platelet (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR88 Gene



Protein tissue co-expression partners for WDR88 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR88 Gene:

WDR88

SOURCE GeneReport for Unigene cluster for WDR88 Gene:

Hs.211046
genes like me logo Genes that share expression patterns with WDR88: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR88 Gene

Orthologs for WDR88 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR88 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia WDR88 34 35
  • 81.57 (n)
dog
(Canis familiaris)
Mammalia WDR88 34 35
  • 79.5 (n)
rat
(Rattus norvegicus)
Mammalia Wdr88 34
  • 76.95 (n)
mouse
(Mus musculus)
Mammalia Wdr88 34 16
  • 74.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR88 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR88 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR88 34
  • 62.96 (n)
lizard
(Anolis carolinensis)
Reptilia WDR88 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr88 34
  • 58.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUP1 35
  • 14 (a)
OneToOne
Species where no ortholog for WDR88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR88 Gene

ENSEMBL:
Gene Tree for WDR88 (if available)
TreeFam:
Gene Tree for WDR88 (if available)

Paralogs for WDR88 Gene

Paralogs for WDR88 Gene

(7) SIMAP similar genes for WDR88 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR88: view

Variants for WDR88 Gene

Sequence variations from dbSNP and Humsavar for WDR88 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035892 A breast cancer sample
rs1000145500 -- 33,173,461(+) CTCTC(C/T)GCTGG intron-variant
rs1000199153 -- 33,174,662(+) GGTTC(G/T)GTAAA intron-variant, utr-variant-3-prime
rs1000264937 -- 33,148,178(+) TCACT(C/T)TCCGT intron-variant
rs1000303596 -- 33,135,449(+) AGTCT(C/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR88 Gene

Variant ID Type Subtype PubMed ID
esv2657217 CNV deletion 23128226
esv2677868 CNV deletion 23128226
esv2718468 CNV deletion 23290073
esv3583345 CNV loss 25503493
esv3583346 CNV loss 25503493
esv3644182 CNV loss 21293372
esv3644183 CNV loss 21293372
nsv1057752 CNV gain 25217958
nsv1062625 CNV gain 25217958
nsv472030 CNV novel sequence insertion 20440878
nsv828525 CNV loss 20364138
nsv833808 CNV loss 17160897

Variation tolerance for WDR88 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.54; 72.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR88 Gene

Human Gene Mutation Database (HGMD)
WDR88
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR88 Gene

Disorders for WDR88 Gene

Relevant External Links for WDR88

Genetic Association Database (GAD)
WDR88
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR88

No disorders were found for WDR88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR88 Gene

Publications for WDR88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Exome arrays capture polygenic rare variant contributions to schizophrenia. (PMID: 26740555) Richards A.L. … O'Donovan M.C. (Hum. Mol. Genet. 2016) 3 64
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  4. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for WDR88 Gene

Sources for WDR88 Gene

Content
Loading form....