WDR88 Gene
protein-coding GIFtS: 41
GCID: GC19P033622
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WD repeat domain 88(Previous name: PQQ repeat and WD repeat domain containing )
(Previous symbol: PQWD)
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Aliases
for WDR88 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 881 2 | | PQWD1 2 3 | | PQQ Repeat And WD Repeat Domain Containing1 2 | | PQQ Repeat And WD Repeat-Containing Protein2 3 | | WD Repeat-Containing Protein 882 |
Export aliases for WDR88 gene to outside databasesPrevious GC identifers: GC19P038316 GC19P030125 |
Summaries
for WDR88 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR88 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR88 gene promoter:
SRF GATA-3 SRF (504 AA) GATA-1 GATA-2 FOXC1 FOXO4 HSF2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR88
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR88 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11WDR88 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P033622: view genomic region
(about GC identifiers)
Start:
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33,622,996 bp from pter |
End:
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33,666,705 bp from pter |
Size:
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43,710 bases |
Orientation:
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plus strand |
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Proteins
for WDR88 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR88_HUMAN, Q6ZMY6 (See
protein sequence)Recommended Name: WD repeat-containing protein 88 Size: 472 amino acids; 52621 Da
Sequence caution: Sequence=AAH31227.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q8NEF8Alternative splicing: 2 isoforms: Q6ZMY6-1 Q6ZMY6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR88: NX_Q6ZMY6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZMY6
WDR88 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775750.3
ENSEMBL proteins: ENSP00000467383 ENSP00000355148 ENSP00000348129
Human Recombinant Protein Products:
WDR88 Antibody Products:
Assay Products for WDR88: |
Protein
Domains /
Families
for WDR88 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR88 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q6ZMY6ProtoNet protein and cluster: Q6ZMY6 1 Blocks protein family: IPB002372 Bacterial quinoprotein
UniProtKB/Swiss-Prot: WDR88_HUMAN, Q6ZMY6Similarity: Contains 7 WD repeats |
Function
for WDR88 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR88
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR88
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR88 (NM_173479) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR88 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR88 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR88 |
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Pathways & Interactions
for WDR88 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR88
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for WDR88 (Q6ZMY63 ENSP000003481294) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR88 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR88
Search CenterWatch for drugs/clinical trials and news about WDR88
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Transcripts
for WDR88 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR88 gene: NM_173479.3 Unigene Cluster for WDR88: WD repeat domain 88 Hs.211046 [show with all ESTs]Unigene Representative Sequence: AK1314443 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592765 ENST00000361680 ENST00000355868(uc002nui.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR88
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR88
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR88 (NM_173479) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR88 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR88 |
Additional cDNA sequence: AK131444.1 BC031227.1 2 DOTS entries: DT.95359841 DT.75128521 9 AceView cDNA sequences: AI982942 AI825732 BI826378 BC031227 BI560259 BI460849 AK131444 NM_173479 BX109140
GeneLoc Exon Structure
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Expression
for WDR88 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR88 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGCCTGA
About this image
See WDR88 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR88
SOURCE GeneReport for Unigene cluster: Hs.211046
SABiosciences Custom PCR Arrays for WDR88
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR88
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR88 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR88 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR88 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR88 |
Orthologs
for WDR88 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WDR88 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for WDR88 (if available)
TreeFam Gene Tree for WDR88 (if available) |
Paralogs
for WDR88 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR88 gene
- POC1B2 WDR832 WDR52 ATG16L12 SNRNP402 WDR5B2 KATNB12 PAFAH1B12
- PRPF42 DAW12 WDR382 ATG16L22 POC1A2 WDSUB12
7 SIMAP similar genes for WDR88 using alignment to 2 protein entries: WDR88_HUMAN (see all proteins):WSB1 PF20 POC1B WDR38 WDR5 WDR83
DKFZp762M0115
WDR88 for paralogs About GeneDecksing
|
Genomic Variants
for WDR88 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for WDR88 (33622996 - 33666705 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR88: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR88 |
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Disorders
/ Diseases
for WDR88 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR88 for disorders About GeneDecksing
2  diseases for WDR88: About MalaCardsfanconi's anemia anemia
Export disorders for WDR88 gene to outside databases
|
Publications
for WDR88 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR88 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR88) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for WDR88 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing WDR88 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR88 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR88 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR88 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for WDR88 gene:
Search GeneIP for patents involving WDR88
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR88 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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 | | | WDR88 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR88 |
|  |  |  | | | | Search ThermoFisher Antibodies for WDR88 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR88 |
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