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Aliases for WDR88 Gene

Aliases for WDR88 Gene

  • WD Repeat Domain 88 2 3
  • PQQ Repeat And WD Repeat-Containing Protein 3 4
  • PQQ Repeat And WD Repeat Domain Containing 2 3
  • PQWD 3 4
  • WD Repeat-Containing Protein 88 3

External Ids for WDR88 Gene

Previous Symbols for WDR88 Gene

  • PQWD

Summaries for WDR88 Gene

GeneCards Summary for WDR88 Gene

WDR88 (WD Repeat Domain 88) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR88 Gene

Genomics for WDR88 Gene

Genomic Location for WDR88 Gene

Start:
33,132,043 bp from pter
End:
33,176,923 bp from pter
Size:
44,881 bases
Orientation:
Plus strand

Genomic View for WDR88 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR88 Gene

Regulatory Elements for WDR88 Gene

Proteins for WDR88 Gene

  • Protein details for WDR88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMY6-WDR88_HUMAN
    Recommended name:
    WD repeat-containing protein 88
    Protein Accession:
    Q6ZMY6
    Secondary Accessions:
    • Q8NEF8

    Protein attributes for WDR88 Gene

    Size:
    472 amino acids
    Molecular mass:
    52621 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31227.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR88 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR88 Gene

Proteomics data for WDR88 Gene at MOPED

Post-translational modifications for WDR88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR88 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR88 Gene

Domains for WDR88 Gene

Gene Families for WDR88 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMY6

UniProtKB/Swiss-Prot:

WDR88_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • Q6ZMY6
genes like me logo Genes that share domains with WDR88: view

Function for WDR88 Gene

Gene Ontology (GO) - Molecular Function for WDR88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR88: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR88 Gene

Localization for WDR88 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR88 Gene COMPARTMENTS Subcellular localization image for WDR88 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR88 Gene

Pathways for WDR88 Gene

SuperPathways for WDR88 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR88 Gene

None

No data available for Pathways by source for WDR88 Gene

Transcripts for WDR88 Gene

mRNA/cDNA for WDR88 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR88 Gene

WD repeat domain 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR88 Gene

No ASD Table

Relevant External Links for WDR88 Gene

GeneLoc Exon Structure for
WDR88
ECgene alternative splicing isoforms for
WDR88

Expression for WDR88 Gene

mRNA expression in normal human tissues for WDR88 Gene

mRNA differential expression in normal tissues according to GTEx for WDR88 Gene

This gene is overexpressed in Testis (20.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WDR88 Gene

SOURCE GeneReport for Unigene cluster for WDR88 Gene Hs.211046

genes like me logo Genes that share expressions with WDR88: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR88 Gene

Orthologs for WDR88 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR88 35
  • 99.15 (n)
  • 98.73 (a)
WDR88 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR88 35
  • 81.57 (n)
  • 73.85 (a)
WDR88 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR88 35
  • 79.5 (n)
  • 71.75 (a)
WDR88 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr88 35
  • 74.65 (n)
  • 67.74 (a)
Wdr88 16
oppossum
(Monodelphis domestica)
Mammalia WDR88 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR88 36
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr88 35
  • 76.95 (n)
  • 69.14 (a)
chicken
(Gallus gallus)
Aves WDR88 35
  • 62.96 (n)
  • 55.82 (a)
lizard
(Anolis carolinensis)
Reptilia WDR88 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr88 35
  • 58.68 (n)
  • 48.16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUP1 36
  • 14 (a)
OneToOne
Species with no ortholog for WDR88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR88 Gene

ENSEMBL:
Gene Tree for WDR88 (if available)
TreeFam:
Gene Tree for WDR88 (if available)

Paralogs for WDR88 Gene

Selected SIMAP similar genes for WDR88 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with WDR88: view

No data available for Paralogs for WDR88 Gene

Variants for WDR88 Gene

Sequence variations from dbSNP and Humsavar for WDR88 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1267936 -- 33,152,337(+) tgtgc(A/G)accat intron-variant
rs1267937 -- 33,146,056(+) gaggc(C/T)gaggc intron-variant
rs1267938 -- 33,133,214(+) agaga(A/G)agaaa intron-variant
rs1267939 -- 33,134,393(+) TCGCC(A/T)TGTTG intron-variant
rs1270252 -- 33,132,698(+) TGGGA(A/G)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR88 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
esv2657217 CNV Deletion 23128226
esv2677868 CNV Deletion 23128226
esv2718468 CNV Deletion 23290073
nsv828525 CNV Loss 20364138

Relevant External Links for WDR88 Gene

HapMap Linkage Disequilibrium report
WDR88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR88 Gene

Disorders for WDR88 Gene

Relevant External Links for WDR88

Genetic Association Database (GAD)
WDR88
genes like me logo Genes that share disorders with WDR88: view

No data available for UniProtKB/Swiss-Prot for WDR88 Gene

Publications for WDR88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PMID: 19850743) Vanderwerf S.M. … Bagby G.C. (Blood 2009) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4

Products for WDR88 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate WDR88
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for WDR88
    • Block miRNA regulation of WDR88 using miScript Target Protectors

    Sources for WDR88 Gene

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