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Aliases for WDR87 Gene

Aliases for WDR87 Gene

  • WD Repeat Domain 87 2 3 5
  • Testis Development Protein NYD-SP11 3 4
  • WD Repeat-Containing Protein 87 3
  • NYD-SP11 3

External Ids for WDR87 Gene

Previous GeneCards Identifiers for WDR87 Gene

  • GC19M043069
  • GC19M038376
  • GC19M034824

Summaries for WDR87 Gene

GeneCards Summary for WDR87 Gene

WDR87 (WD Repeat Domain 87) is a Protein Coding gene. GO annotations related to this gene include binding and nicotinate-nucleotide diphosphorylase (carboxylating) activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR87 Gene

Genomics for WDR87 Gene

Regulatory Elements for WDR87 Gene

Enhancers for WDR87 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F037961 1 Ensembl ENCODE 30.4 -56.1 -56145 3.2 HDGF ATF1 PKNOX1 CREB3L1 ZNF121 KLF13 SP3 REST TBX21 ZNF623 ZNF607 WDR87 LINC01535 ZNF793 ZNF585B SIPA1L3 ZNF571 FAM98C ZNF781 ENSG00000267152
GH19F037960 0.6 Ensembl 29.5 -53.5 -53495 0.4 RAD51 MXI1 MTA2 NBN TRIM22 MLLT1 EP300 WDR87 SIPA1L3 ENSG00000268051 GC19P037934
GH19F037973 1.1 FANTOM5 Ensembl ENCODE 29.4 -71.9 -71861 10.0 HDGF PKNOX1 WRNIP1 ZNF133 DMAP1 YBX1 ZNF48 ZNF2 YY1 ZNF121 WDR87 ENSG00000266963 LINC01535 ENSG00000269445 ENSG00000267375 ZNF585B SIPA1L3 ZNF383 ZNF585A ZNF607
GH19F037965 1.2 Ensembl ENCODE 28.9 -60.0 -60006 1.9 KLF1 BCL11B ZIC2 TEAD3 ZFHX2 ZNF366 ZBTB48 POLR2A SCRT2 NR2F6 WDR87 LINC01535 ZNF607 ZNF383 SIPA1L3 ZNF585B PPP1R14A SPINT2 LOC100631378 ZNF781
GH19F037952 1 Ensembl ENCODE 28.3 -47.2 -47232 2.1 ZNF792 ZNF76 MAX ZIC2 ZFHX2 ZBTB48 PATZ1 SCRT2 EED PRDM10 WDR87 LINC01535 ZNF781 ZNF607 SIPA1L3 CATSPERG ENSG00000268051 GC19P037934
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR87 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR87 Gene

Chromosome:
19
Start:
37,884,573 bp from pter
End:
37,906,706 bp from pter
Size:
22,134 bases
Orientation:
Minus strand

Genomic View for WDR87 Gene

Genes around WDR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR87 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR87 Gene

Proteins for WDR87 Gene

  • Protein details for WDR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQQ6-WDR87_HUMAN
    Recommended name:
    WD repeat-containing protein 87
    Protein Accession:
    Q6ZQQ6
    Secondary Accessions:
    • Q9BWV9

    Protein attributes for WDR87 Gene

    Size:
    2873 amino acids
    Molecular mass:
    333185 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR87 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR87 Gene

Post-translational modifications for WDR87 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR87 Gene

No data available for DME Specific Peptides for WDR87 Gene

Domains & Families for WDR87 Gene

Gene Families for WDR87 Gene

Suggested Antigen Peptide Sequences for WDR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZQQ6

UniProtKB/Swiss-Prot:

WDR87_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR87: view

Function for WDR87 Gene

Phenotypes for WDR87 Gene

GenomeRNAi human phenotypes for WDR87:
genes like me logo Genes that share phenotypes with WDR87: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR87 Gene

Localization for WDR87 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR87 Gene COMPARTMENTS Subcellular localization image for WDR87 gene
Compartment Confidence
nucleus 2
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR87 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with WDR87: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR87 Gene

Pathways & Interactions for WDR87 Gene

SuperPathways for WDR87 Gene

No Data Available

Interacting Proteins for WDR87 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368025%0d%0a9606.ENSP00000296452%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000368025 for WDR87 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR87 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR87 Gene

Transcripts for WDR87 Gene

mRNA/cDNA for WDR87 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR87 Gene

WD repeat domain 87:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR87 Gene

No ASD Table

Relevant External Links for WDR87 Gene

GeneLoc Exon Structure for
WDR87
ECgene alternative splicing isoforms for
WDR87

Expression for WDR87 Gene

mRNA expression in normal human tissues for WDR87 Gene

mRNA differential expression in normal tissues according to GTEx for WDR87 Gene

This gene is overexpressed in Testis (x46.6).

Protein differential expression in normal tissues from HIPED for WDR87 Gene

This gene is overexpressed in Liver (25.3), Synovial fluid (12.4), and Platelet (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR87 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR87 Gene:

WDR87

SOURCE GeneReport for Unigene cluster for WDR87 Gene:

Hs.664194
genes like me logo Genes that share expression patterns with WDR87: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDR87 Gene

Orthologs for WDR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR87 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR87 34 35
  • 97.97 (n)
cow
(Bos Taurus)
Mammalia WDR87 34 35
  • 78.16 (n)
dog
(Canis familiaris)
Mammalia WDR87 34 35
  • 77.2 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 53 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 4932431P20Rik 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR87 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR87 35
  • 34 (a)
OneToOne
Species where no ortholog for WDR87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR87 Gene

ENSEMBL:
Gene Tree for WDR87 (if available)
TreeFam:
Gene Tree for WDR87 (if available)

Paralogs for WDR87 Gene

(1) SIMAP similar genes for WDR87 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WDR87 Gene

genes like me logo Genes that share paralogs with WDR87: view

No data available for Paralogs for WDR87 Gene

Variants for WDR87 Gene

Sequence variations from dbSNP and Humsavar for WDR87 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404567 -- 37,906,573(+) CAACT(A/G)AGAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10408510 -- 37,885,845(+) CTTCA(A/T)GTTTG intron-variant, reference, missense
rs10422056 -- 37,887,899(+) ATCTT(C/G)TTGAA intron-variant, reference, missense
rs10618499 -- 37,902,050(+) TATTT(-/ATTTATTT)GCCAC intron-variant
rs10676914 -- 37,905,467(+) AGTAA(-/GTAA)ATAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR87 Gene

Variant ID Type Subtype PubMed ID
esv3390200 CNV insertion 20981092
esv3583378 CNV loss 25503493
nsv1064401 CNV loss 25217958
nsv833820 CNV loss 17160897

Variation tolerance for WDR87 Gene

Gene Damage Index Score: 9.02; 87.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR87 Gene

Human Gene Mutation Database (HGMD)
WDR87
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR87 Gene

Disorders for WDR87 Gene

Relevant External Links for WDR87

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR87

No disorders were found for WDR87 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR87 Gene

Publications for WDR87 Gene

  1. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for WDR87 Gene

Sources for WDR87 Gene

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