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WDR87 Gene(Protein Coding)

WD Repeat Domain 87

GCID:
GC19M037884
GIFtS:
34
Genes Participants
UDN Logo

Aliases for WDR87 Gene

Aliases for WDR87 Gene

  • WD Repeat Domain 87 2 3 5
  • Testis Development Protein NYD-SP11 3 4
  • WD Repeat-Containing Protein 87 3
  • NYD-SP11 3

External Ids for WDR87 Gene

Previous GeneCards Identifiers for WDR87 Gene

  • GC19M043069
  • GC19M038376
  • GC19M034824

Summaries for WDR87 Gene

GeneCards Summary for WDR87 Gene

WDR87 (WD Repeat Domain 87) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding and nicotinate-nucleotide diphosphorylase (carboxylating) activity.

Additional gene information for WDR87 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR87 Gene

Genomics for WDR87 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for WDR87 Gene

Promoters and enhancers for WDR87 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I037905 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 570 -1.0 -1011 4.2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF416 ZNF143 WDR87 SIPA1L3 ZFP30 HKR1 ZNF527 ZNF383 ZNF607 LINC01535 ZNF571 LOC100631378
GH19I037898 Promoter/Enhancer 1.2 EPDnew ENCODE 550.4 +7.9 7880 0.2 MEIS2 CTCF KLF1 PKNOX1 RB1 SIN3A BACH1 KLF5 RAD21 ZNF335 WDR87 LINC01535 PIR42352
GH19I037973 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 29.4 -71.9 -71860 10 HDGF PKNOX1 FOXA2 SMAD1 DMAP1 ZNF2 IRF4 ZNF48 ZNF121 ZNF207 ZNF585A ZNF585B HKR1 ZNF607 WDR87 ZFP30 ZNF420 ZNF793 LINC01535 ZNF527
GH19I037778 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16.6 +127.2 127243 2.3 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 POLR2B ZNF766 ZNF573 LOC728533 ZNF345 ZNF383 ZFP30 ZNF527 ZNF585B ZNF790 ZNF781 ZNF571
GH19I037952 Enhancer 1.2 Ensembl ENCODE dbSUPER 28.4 -47.2 -47225 2.1 USF1 ZNF792 ZNF449 ZSCAN4 MAX MZF1 ZIC2 ZNF335 ZFHX2 GLIS2 WDR87 LINC01535 ZNF781 HKR1 ZNF527 ZNF607 HNRNPL ZNF585B SIPA1L3 ZNF383
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR87 on UCSC Golden Path with GeneCards custom track

Genomic Locations for WDR87 Gene

Genomic Locations for WDR87 Gene
chr19:37,884,573-37,906,706
(GRCh38/hg38)
Size:
22,134 bases
Orientation:
Minus strand
chr19:38,375,463-38,397,317
(GRCh37/hg19)

Genomic View for WDR87 Gene

Genes around WDR87 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR87 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR87 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR87 Gene

Proteins for WDR87 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WDR87 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQQ6-WDR87_HUMAN
    Recommended name:
    WD repeat-containing protein 87
    Protein Accession:
    Q6ZQQ6
    Secondary Accessions:
    • Q9BWV9

    Protein attributes for WDR87 Gene

    Size:
    2873 amino acids
    Molecular mass:
    333185 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp.; Evidence={ECO:0000305}; Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR87 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR87 Gene

Protein Expression for WDR87 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR87 Gene

No Post-translational modifications

Other Protein References for WDR87 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR87 Gene

Domains & Families for WDR87 Gene

Gene Families for WDR87 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR87 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDR87 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR87: view

No data available for UniProtKB/Swiss-Prot for WDR87 Gene

Function for WDR87 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for WDR87 Gene

Phenotypes for WDR87 Gene

GenomeRNAi human phenotypes for WDR87:
genes like me logo Genes that share phenotypes with WDR87: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR87 Gene

Localization for WDR87 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR87 gene
Compartment Confidence
plasma membrane 2
nucleus 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR87 Gene

Pathways & Interactions for WDR87 Gene

SuperPathways for WDR87 Gene

PathCards logo More details on SuperPathways for WDR87
No Data Available

Interacting Proteins for WDR87 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368025%0d%0a9606.ENSP00000296452%0d%0a9606.ENSP00000370589%0d%0a
Selected Interacting proteins: ENSP00000368025 for WDR87 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR87 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR87 Gene

Drugs & Compounds for WDR87 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WDR87 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for WDR87 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR87 Gene

WD repeat domain 87:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR87 Gene

No ASD Table

Relevant External Links for WDR87 Gene

GeneLoc Exon Structure for
WDR87
ECgene alternative splicing isoforms for
WDR87

Expression for WDR87 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR87 Gene

mRNA expression in normal human tissues for WDR87 Gene
mRNA expression by BioGPS for WDR87 GenemRNA expression by GTEx for WDR87 Gene

mRNA differential expression in normal tissues according to GTEx for WDR87 Gene

This gene is overexpressed in Testis (x46.6).

Protein differential expression in normal tissues from HIPED for WDR87 Gene

This gene is overexpressed in Liver (25.3), Synovial fluid (12.4), and Platelet (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR87 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR87 Gene:

WDR87

SOURCE GeneReport for Unigene cluster for WDR87 Gene:

Hs.664194
genes like me logo Genes that share expression patterns with WDR87: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR87 Gene

Orthologs for WDR87 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR87 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia WDR87 33 34
  • 97.97 (n)
cow
(Bos Taurus)
 Mammalia WDR87 33 34
  • 78.16 (n)
dog
(Canis familiaris)
 Mammalia WDR87 33 34
  • 77.2 (n)
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 53 (a)
 OneToMany
-- 34
  • 39 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia 4932431P20Rik 34
  • 48 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia WDR87 34
  • 45 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia WDR87 34
  • 34 (a)
 OneToOne
Species where no ortholog for WDR87 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for WDR87 Gene

ENSEMBL:
Gene Tree for WDR87 (if available)
TreeFam:
Gene Tree for WDR87 (if available)

Paralogs for WDR87 Gene

(1) SIMAP similar genes for WDR87 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for WDR87 Gene

genes like me logo Genes that share paralogs with WDR87: view

No data available for Paralogs for WDR87 Gene

Variants for WDR87 Gene

Sequence variations from dbSNP and Humsavar for WDR87 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000023629 -- 37,905,867(-) G/C intron_variant
rs1000351543 -- 37,899,244(-) C/A intron_variant
rs1000545913 -- 37,906,729(-) A/AGA upstream_transcript_variant
rs1000571172 -- 37,899,730(-) G/A intron_variant
rs1000948697 -- 37,901,139(-) A/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR87 Gene

Variant ID Type Subtype PubMed ID
esv3390200 CNV insertion 20981092
esv3583378 CNV loss 25503493
nsv1064401 CNV loss 25217958
nsv833820 CNV loss 17160897

Variation tolerance for WDR87 Gene

Gene Damage Index Score: 9.02; 87.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR87 Gene

Human Gene Mutation Database (HGMD)
WDR87
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR87

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR87 Gene

Disorders for WDR87 Gene

Additional Disease Information for WDR87

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR87 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR87 Gene

Publications for WDR87 Gene

  1. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for WDR87 Gene

Sources for WDR87 Gene

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