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WDR87 Gene

protein-coding   GIFtS: 38
GCID: GC19M038376

WD Repeat Domain 87

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Aliases
for WDR87 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 871 2
Testis Development Protein NYD-SP112 3
NYD-SP112
WD Repeat-Containing Protein 872

External Ids:    HGNC: 299341   Entrez Gene: 838892   Ensembl: ENSG000001718047   UniProtKB: Q6ZQQ63   

Export aliases for WDR87 gene to outside databases

Previous GC identifers: GC19M043069 GC19M034824


Summaries
for WDR87 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR87 Gene:
WDR87 (WD repeat domain 87) is a protein-coding gene.


Genomic Views
for WDR87 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for WDR87
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for WDR87

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.13   HGNC cytogenetic band: 19q13.13

WDR87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR87 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038376:  view genomic region     (about GC identifiers)

Start:
 38,375,463 bp from pter      End:
 38,397,317 bp from pter
Size:
 21,855 bases      Orientation:
 minus strand

Proteins
for WDR87 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6 (See protein sequence)
Recommended Name: WD repeat-containing protein 87  
Size: 2873 amino acids; 333185 Da
Sequence caution: Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp;
Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140;
Secondary accessions: Q9BWV9
Alternative splicing: 2 isoforms:  Q6ZQQ6-1   Q6ZQQ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR87: NX_Q6ZQQ6

Explore proteomics data for WDR87 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See WDR87 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001278017.1  NP_114157.4  

    ENSEMBL proteins: 
     ENSP00000405012   ENSP00000368025  

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    Domains /
    Families
    for WDR87 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZQQ6

    ProtoNet protein and cluster: Q6ZQQ6

    UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR87           About GenesLikeMe


    Function
    for WDR87 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004514nicotinate-nucleotide diphosphorylase (carboxylating) activity ----
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR87           About GenesLikeMe


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    Localization
    for WDR87 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    plasma membrane2
    cytosol1
    peroxisome1

    Pathways & Interactions
    for WDR87 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Interactions:

        Search GeneGlobe Interaction Network for WDR87

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009435NAD biosynthetic process ----

    Find genes that share ontologies with WDR87           About GenesLikeMe



    Drugs & Compounds
    for WDR87 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for WDR87



    Transcripts
    for WDR87 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR87 gene (2 alternative transcripts): 
    NM_001291088.1  NM_031951.4  

    Unigene Cluster for WDR87:

    WD repeat domain 87
    Hs.664194  [show with all ESTs]
    Unigene Representative Sequence: NM_031951
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447313(uc010efu.2 uc002ohj.2) ENST00000303868 ENST00000473328

    miRNA
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    hsa-miR-601
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK128826.1 AK301941.1 AK302913.1 AY026504.2 

    2 DOTS entries:

    DT.101970166  DT.91644169 

    5 AceView cDNA sequences:

    BX280819 AK128826 AY026504 AA629294 CD558379 

    GeneLoc Exon Structure


    Expression
    for WDR87 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGAACTGT
    WDR87 Expression
    About this image

    WDR87 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    WDR87 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664194
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    Orthologs
    for WDR87 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WDR87 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia WDR876
    		 WD repeat domain 87
    		 34(a)
    		 1 ↔ 1
    		 LGf(2432276-2444180)
            Species with no ortholog for WDR87

    ENSEMBL Gene Tree for WDR87 (if available)
    TreeFam Gene Tree for WDR87 (if available)

    Paralogs
    for WDR87 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR87 gene
    1 SIMAP similar gene for WDR87 using alignment to 2 protein entries:     WDR87_HUMAN (see all proteins):
    GNB5

    Find genes that share paralogs with WDR87           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WDR87
    PGOHUM00000234308


    Genomic Variants
    for WDR87 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR87 (see all 453)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116733611,2
    		H--38375015(+) TCTTAG/AAGTGC 1 -- ds50014Minor allele frequency- A:0.00NS EA 398
    rs48035411,2
    		C,F,A--38375065(+) AGACTC/TGTCTG 1 -- ds50018Minor allele frequency- T:0.45NA WA CSA EA 368
    rs1387929361,2
    		--38375135(+) GAGTAC/TGTGAG 1 -- ds50010--------
    rs1831706421,2
    		--38375136(+) AGTACA/GTGAGT 1 -- ds50010--------
    rs621102341,2
    		C,F--38375278(+) GCTTCG/AACCTG 1 -- ds50012Minor allele frequency- A:0.04NA 122
    rs1878025621,2
    		--38375279(+) CTTCGA/GCCTGG 1 -- ds50010--------
    rs48035421,2
    		C,F,A--38375290(+) CCCTAC/GCTCTG 1 -- ds50019Minor allele frequency- G:0.47NA WA CSA EA 370
    rs1915377191,2
    		C--38375308(+) CTAGAA/GATGAA 1 -- ds50010--------
    rs1847857711,2
    		--38375324(+) AGGGCC/TGGGCG 1 -- ds50010--------
    rs48035431,2
    		C,F,A--38375392(+) GAACCC/TGGGAG 1 -- ds50015Minor allele frequency- T:0.39NA WA CSA EA 246

    HapMap Linkage Disequilibrium report for WDR87 (38375463 - 38397317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR87:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833820CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for WDR87 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		   --

    Publications
    for WDR87 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR87 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WDR87)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

    External Searches for WDR87 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WDR87 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83889 HGNC: 29934 AceView: NYD-SP11 Ensembl:ENSG00000171804 euGenes: HUgn83889
    ECgene: WDR87 H-InvDB: WDR87

    Other Databases showing WDR87 gene

    (According to HUGE)
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    Specialized Databases showing WDR87 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR87 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR87 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for WDR87 gene:
    Search GeneIP for patents involving WDR87

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for WDR87 gene

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