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WDR87 Gene

protein-coding GIFtS: 38
GCID: GC19M038376

WD Repeat Domain 87

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
WD Repeat Domain 87¹ ²
Testis Development Protein NYD-SP11² ³
NYD-SP11²
WD Repeat-Containing Protein 87²

External Ids:	HGNC: 29934¹	Entrez Gene: 83889²	Ensembl: ENSG00000171804⁷	UniProtKB: Q6ZQQ6³

Export aliases for WDR87 gene to outside databases

Previous GC identifers: GC19M043069 GC19M034824

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR87 Gene:

WDR87 (WD repeat domain 87) is a protein-coding gene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000019.9 NT_011109.17 NC_018930.2

Regulatory elements:

Search for regulatory transcription factor binding sites for WDR87
Other transcription factors

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Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR87

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.13 HGNC cytogenetic band: 19q13.13

WDR87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR87 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M038376: view genomic region (about GC identifiers)

Start:	38,375,463 bp from pter	End:	38,397,317 bp from pter
Size:	21,855 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6 (See protein sequence)

Recommended Name: WD repeat-containing protein 87

Size: 2873 amino acids; 333185 Da

Sequence caution: Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp;

Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140;

Secondary accessions: Q9BWV9

Alternative splicing: 2 isoforms: Q6ZQQ6-1 Q6ZQQ6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR87: NX_Q6ZQQ6

Explore proteomics data for WDR87 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See WDR87 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001278017.1 NP_114157.4

ENSEMBL proteins:

ENSP00000405012 ENSP00000368025

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

WDR: WD repeat domain containing

4 InterPro protein domains:

IPR011047 Quinonprotein_ADH-like_supfam

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q6ZQQ6

ProtoNet protein and cluster: Q6ZQQ6

UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6

Similarity: Contains 7 WD repeats

Find genes that share domains with WDR87 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	--	--
GO:0005488	binding	--	--
GO:0005515	protein binding	--	--

Find genes that share ontologies with WDR87 About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	2
plasma membrane	2
cytosol	1
peroxisome	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Interactions:

Search GeneGlobe Interaction Network for WDR87

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009435	NAD biosynthetic process	--	--

Find genes that share ontologies with WDR87 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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About This Section

REFSEQ mRNAs for WDR87 gene (5 alternative transcripts):

NM_001291088.1 NM_031951.4 XM_005259304.2 XM_005259305.2 XM_006723411.1

Unigene Cluster for WDR87:

WD repeat domain 87

Hs.664194 [show with all ESTs]

Unigene Representative Sequence: NM_031951

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000447313(uc010efu.2 uc002ohj.2) ENST00000303868 ENST00000473328

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Additional mRNA sequence:

AK128826.1 AK301941.1 AK302913.1 AY026504.2

2 DOTS entries:

DT.101970166 DT.91644169

5 AceView cDNA sequences:

BX280819 AK128826 AY026504 AA629294 CD558379

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR87 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAGAACTGT

About this image

WDR87 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

WDR87 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.664194

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WDR87 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	WDR87⁶	WD repeat domain 87	34(a)	1 ↔ 1	LGf(2432276-2444180)

Species with no ortholog for WDR87

ENSEMBL Gene Tree for WDR87 (if available)
TreeFam Gene Tree for WDR87 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for WDR87 gene

1 SIMAP similar gene for WDR87 using alignment to 2 protein entries: WDR87_HUMAN (see all proteins):

GNB5

Find genes that share paralogs with WDR87 About GenesLikeMe

1 Pseudogenes.org Pseudogene for WDR87
PGOHUM00000234308

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11673361^1,2	H	--	38375015(+)	`TCTTAG/AAGTGC`	1	--	ds500¹		4		NS EA	398
rs4803541^1,2	C,F,A	--	38375065(+)	`AGACTC/TGTCTG`	1	--	ds500¹		8		NA WA CSA EA	368
rs138792936^1,2		--	38375135(+)	`GAGTAC/TGTGAG`	1	--	ds500¹		0	--	--	--	--
rs183170642^1,2		--	38375136(+)	`AGTACA/GTGAGT`	1	--	ds500¹		0	--	--	--	--
rs62110234^1,2	C,F	--	38375278(+)	`GCTTCG/AACCTG`	1	--	ds500¹		2		NA	122
rs187802562^1,2		--	38375279(+)	`CTTCGA/GCCTGG`	1	--	ds500¹		0	--	--	--	--
rs4803542^1,2	C,F,A	--	38375290(+)	`CCCTAC/GCTCTG`	1	--	ds500¹		9		NA WA CSA EA	370
rs191537719^1,2	C	--	38375308(+)	`CTAGAA/GATGAA`	1	--	ds500¹		0	--	--	--	--
rs184785771^1,2		--	38375324(+)	`AGGGCC/TGGGCG`	1	--	ds500¹		0	--	--	--	--
rs4803543^1,2	C,F,A	--	38375392(+)	`GAACCC/TGGGAG`	1	--	ds500¹		5		NA WA CSA EA	246

HapMap Linkage Disequilibrium report for WDR87 (38375463 - 38397317 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for WDR87: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833820	CNV	Loss	17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR87 gene integrated from 10 sources:
(articles sorted by number of sources associating them with WDR87)

Utopia: connect your pdf to the dynamic
world of online information

Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (Nature 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83889	HGNC: 29934	AceView: NYD-SP11	Ensembl:ENSG00000171804	euGenes: HUgn83889
ECgene: WDR87	H-InvDB: WDR87

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR87	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR87 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR87 gene:
Search GeneIP for patents involving WDR87

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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WDR87 Gene

WD Repeat Domain 87

Aliases
for WDR87 gene

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for WDR87 gene

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for WDR87 gene

Proteins
for WDR87 gene

WDR87 Human Recombinant Protein Products:

WDR87 Antibody Products:

WDR87 Assay Products:

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Transcripts
for WDR87 gene

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for WDR87 gene

Orthologs
for WDR87 gene

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for WDR87 gene

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for WDR87 gene

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for WDR87 gene

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for WDR87 gene

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WDR87 Gene

WD Repeat Domain 87

Aliasesfor WDR87 gene

Summariesfor WDR87 gene

Genomic Viewsfor WDR87 gene

Proteinsfor WDR87 gene

WDR87 Human Recombinant Protein Products:

WDR87 Antibody Products:

WDR87 Assay Products:

Domains /Familiesfor WDR87 gene

Functionfor WDR87 gene

Localizationfor WDR87 gene

Pathways & Interactionsfor WDR87 gene

Drugs & Compoundsfor WDR87 gene

Transcriptsfor WDR87 gene

Expression for WDR87 gene

Orthologsfor WDR87 gene

Paralogsfor WDR87 gene

Genomic Variantsfor WDR87 gene

Disorders / Diseasesfor WDR87 gene

Publicationsfor WDR87 gene

External Searches for WDR87 gene

Genome Databases showing WDR87 gene

Other Databases showing WDR87 gene

Specialized Databases showing WDR87 gene

Intellectual Propertyfor WDR87 gene

Productsfor WDR87 gene

View Random Gene

Aliases
for WDR87 gene

Summaries
for WDR87 gene

Genomic Views
for WDR87 gene

Proteins
for WDR87 gene

Domains /
Families
for WDR87 gene

Function
for WDR87 gene

Localization
for WDR87 gene

Pathways & Interactions
for WDR87 gene

Drugs & Compounds
for WDR87 gene

Transcripts
for WDR87 gene

Expression
for WDR87 gene

Orthologs
for WDR87 gene

Paralogs
for WDR87 gene

Genomic Variants
for WDR87 gene

Disorders / Diseases
for WDR87 gene

Publications
for WDR87 gene

Intellectual Property
for WDR87 gene

Products
for WDR87 gene