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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR87 Gene

protein-coding   GIFtS: 37
GCID: GC19M038376

WD repeat domain 87
  Search for WDR87
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WDR87    

Aliases
for WDR87 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WD Repeat Domain 871 2
NYD-SP111 2
Testis Development Protein NYD-SP112 3
WD Repeat-Containing Protein 872

External Ids:    HGNC: 299341   Entrez Gene: 838892   Ensembl: ENSG000001718047   UniProtKB: Q6ZQQ63   

Export aliases for WDR87 gene to outside databases

Previous GC identifers: GC19M043069 GC19M034824


Summaries
for WDR87 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for WDR87 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WDR87
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WDR87

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.13   Ensembl cytogenetic band:  19q13.13   HGNC cytogenetic band: 19q13.13

WDR87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR87 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M038376:  view genomic region     (about GC identifiers)

Start:
 38,375,463 bp from pter      End:
 38,397,317 bp from pter
Size:
 21,855 bases      Orientation:
 minus strand

Proteins
for WDR87 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6 (See protein sequence)
Recommended Name: WD repeat-containing protein 87  
Size: 2873 amino acids; 333185 Da
Sequence caution: Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp;
Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140;
Secondary accessions: Q9BWV9
Alternative splicing: 2 isoforms:  Q6ZQQ6-1   Q6ZQQ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR87: NX_Q6ZQQ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZQQ6

    • WDR87 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_114157.3  
    ENSEMBL proteins: 
     ENSP00000405012   ENSP00000368025  

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    Protein Domains /
    Families
    for WDR87 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WDR87 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZQQ6

    ProtoNet protein and cluster: Q6ZQQ6

    UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6
    Similarity: Contains 7 WD repeats


    Function
    for WDR87 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    Pathways & Interactions
    for WDR87 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR87

    Drugs & Compounds
    for WDR87 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR87
    Search CenterWatch for drugs/clinical trials and news about WDR87 

    Transcripts
    for WDR87 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WDR87 gene: 
    NM_031951.3  

    Unigene Cluster for WDR87:

    WD repeat domain 87
    Hs.664194  [show with all ESTs]
    Unigene Representative Sequence: NM_031951
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447313(uc010efu.2 uc002ohj.2) ENST00000303868 ENST00000473328


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    hsa-miR-601
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK128826.1 AK301941.1 AK302913.1 AY026504.2 

    2 DOTS entries:

    DT.101970166  DT.91644169 

    5 AceView cDNA sequences:

    BX280819 AK128826 AA629294 CD558379 AY026504 

    GeneLoc Exon Structure


    Expression
    for WDR87 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR87 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGAACTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WDR87 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WDR87 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR87

    SOURCE GeneReport for Unigene cluster: Hs.664194
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    In Situ
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    Orthologs
    for WDR87 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for WDR87 gene from 1/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia WDR876
    		 --
    		 34(a)
    		 1 ↔ 1
    		 LGf(2432276-2444090)
            Species with no ortholog for WDR87

    ENSEMBL Gene Tree for WDR87 (if available)
    TreeFam Gene Tree for WDR87 (if available) 

    Paralogs
    for WDR87 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR87 gene
    1 SIMAP similar gene for WDR87 using alignment to 2 protein entries:     WDR87_HUMAN (see all proteins):
    GNB5

    WDR87 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for WDR87
    PGOHUM00000234308


    Genomic Variants
    for WDR87 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/342 NCBI SNPs in WDR87 are shown (see all 342)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116733611,2
    		H--38375015(+) TCTTAG/AAGTGC 1 -- ds50014Minor allele frequency- A:0.00NS EA 398
    rs48035411,2
    		C,F,A,--38375065(+) AGACTC/TGTCTG 1 -- ds50018Minor allele frequency- T:0.45NA WA CSA EA 368
    rs1387929361,2
    		--38375135(+) GAGTAC/TGTGAG 1 -- ds50010--------
    rs1831706421,2
    		--38375136(+) AGTACA/GTGAGT 1 -- ds50010--------
    rs621102341,2
    		--38375278(+) GCTTCG/AACCTG 1 -- ds50012Minor allele frequency- A:0.04NA 122
    rs1878025621,2
    		--38375279(+) CTTCGA/GCCTGG 1 -- ds50010--------
    rs48035421,2
    		C,F,A,--38375290(+) CCCTAC/GCTCTG 1 -- ds50019Minor allele frequency- G:0.47NA WA CSA EA 370
    rs1915377191,2
    		--38375308(+) CTAGAA/GATGAA 1 -- ds50010--------
    rs1847857711,2
    		--38375324(+) AGGGCC/TGGGCG 1 -- ds50010--------
    rs48035431,2
    		C,F,A,--38375392(+) GAACCC/TGGGAG 1 -- ds50015Minor allele frequency- T:0.39NA WA CSA EA 246

    HapMap Linkage Disequilibrium report for WDR87 (38375463 - 38397317 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for WDR87
         1 CNV: 5099

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    Disorders / Diseases
    for WDR87 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for WDR87 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR87 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR87)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for WDR87 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing WDR87 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83889 HGNC: 29934 AceView: NYD-SP11 Ensembl:ENSG00000171804 euGenes: HUgn83889
    ECgene: WDR87 H-InvDB: WDR87

    Other Databases showing WDR87 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WDR87 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR87 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR87 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WDR87 gene:
    Search GeneIP for patents involving WDR87

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR87
     Browse SwitchGear 3'UTR luciferase reporter plasmids for WDR87
     Browse SwitchGear Promoter luciferase reporter plasmids for WDR87
     Search ThermoFisher Antibodies for WDR87
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WDR87
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
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