WDR87 Gene
protein-coding GIFtS: 38
GCID: GC19M038376
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WD Repeat Domain 87
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Aliases
for WDR87 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| WD Repeat Domain 871 2 | | Testis Development Protein NYD-SP112 3 | | NYD-SP112 | | WD Repeat-Containing Protein 872 |
Export aliases for WDR87 gene to outside databasesPrevious GC identifers: GC19M043069 GC19M034824 |
Summaries
for WDR87 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for WDR87 Gene:
WDR87 (WD repeat domain 87) is a protein-coding gene.
|
Genomic Views
for WDR87 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000019.10 NT_011109.17 NC_018930.2
Regulatory elements:
 Search for regulatory transcription factor binding sites for WDR87
Other transcription factors
Search Chromatin IP Primers for WDR87
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR87 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.13 HGNC cytogenetic band: 19q13.13WDR87 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M038376: view genomic region
(about GC identifiers)
Start:
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38,375,463 bp from pter |
End:
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38,397,317 bp from pter |
Size:
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21,855 bases |
Orientation:
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minus strand |
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Proteins
for WDR87 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6 (See
protein sequence)Recommended Name: WD repeat-containing protein 87 Size: 2873 amino acids; 333185 Da
Sequence caution: Sequence=AAK20167.2; Type=Erroneous termination; Positions=825; Note=Translated as Trp;
Sequence=AAK20167.2; Type=Frameshift; Positions=126, 820, 1129, 1140;
Secondary accessions: Q9BWV9Alternative splicing: 2 isoforms: Q6ZQQ6-1 Q6ZQQ6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR87: NX_Q6ZQQ6
Explore proteomics data for WDR87 at MOPED
Post-translational modifications:  Modification sites at neXtProt Modification sites at PhosphoSitePlus
See WDR87 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins (2 alternative transcripts):
NP_001278017.1 NP_114157.4
ENSEMBL proteins: ENSP00000405012 ENSP00000368025
WDR87 Human Recombinant
Protein Products:WDR87 Antibody
Products:WDR87 Assay Products: |
Domains /
Families
for WDR87 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
WDR: WD repeat domain containing
4 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q6ZQQ6ProtoNet protein and cluster: Q6ZQQ6 UniProtKB/Swiss-Prot: WDR87_HUMAN, Q6ZQQ6Similarity: Contains 7 WD repeats
WDR87 for domains About GeneDecksing
|
Function
for WDR87 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 3 molecular function terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity |
-- | -- | | GO:0005488 | binding |
-- | -- | | GO:0005515 | protein binding |
-- | -- |
WDR87 for ontologies About GeneDecksing
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for WDR87
| | | Predesigned siRNA for gene silencing in human, mouse, rat WDR87 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for WDR87 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for WDR87  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR87 |
Localization
for WDR87 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| nucleus | 2 | | plasma membrane | 2 | | cytosol | 1 | | peroxisome | 1 |
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Pathways & Interactions
for WDR87 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR87
Interactions:
Search GeneGlobe Interaction Network for WDR87
Gene Ontology (GO): 1 biological process term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009435 | NAD biosynthetic process |
-- | -- |
WDR87 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR87 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for WDR87
|
Transcripts
for WDR87 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for WDR87 gene (2 alternative transcripts): NM_001291088.1 NM_031951.4 Unigene Cluster for WDR87: WD repeat domain 87 Hs.664194 [show with all ESTs]Unigene Representative Sequence: NM_0319513 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447313(uc010efu.2 uc002ohj.2) ENST00000303868 ENST00000473328
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for WDR87
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat WDR87 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for WDR87
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDR87 | | | QuantiTect SYBR Green Assays in human, mouse, rat WDR87 | | | QuantiFast Probe-based Assays in human, mouse, rat WDR87 |
Additional mRNA sequence: AK128826.1 AK301941.1 AK302913.1 AY026504.2 2 DOTS entries: DT.101970166 DT.91644169 5 AceView cDNA sequences: BX280819 AK128826 AY026504 AA629294 CD558379
GeneLoc Exon Structure
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Expression
for WDR87 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | WDR87 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAGAACTGT
About this image WDR87 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
SOURCE GeneReport for Unigene cluster: Hs.664194
Custom PCR Arrays for WDR87
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for WDR87
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDR87 | | | QuantiTect SYBR Green Assays in human, mouse, rat WDR87 | | | QuantiFast Probe-based Assays in human, mouse, rat WDR87 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR87 |
Orthologs
for WDR87 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for WDR87 gene from Selected species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
WDR876 |
WD repeat domain 87 |
34(a) |
1 ↔ 1 |
LGf(2432276-2444180) |
Species with no ortholog for WDR87
ENSEMBL Gene Tree for WDR87 (if available)
TreeFam Gene Tree for WDR87 (if available) |
Paralogs
for WDR87 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for WDR87 gene
1 SIMAP similar gene for WDR87 using alignment to 2 protein entries: WDR87_HUMAN (see all proteins):GNB5
WDR87 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WDR87
PGOHUM00000234308
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Genomic Variants
for WDR87 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR87 (38375463 - 38397317 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for WDR87: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing WDR87 |
|
Disorders
/ Diseases
for WDR87 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus | -- |
Publications
for WDR87 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for WDR87 gene integrated from 10 sources:
(articles sorted by number of sources associating them with WDR87) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
- Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
|
External Searches for WDR87 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing WDR87 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing WDR87 gene
(According to HUGE)
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Specialized Databases showing WDR87 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for WDR87 | Pharmacogenomics, SNPs, Pathways |
|
| | |
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TryGeneCards Plus | Patent Information for WDR87 gene:
Search GeneIP for patents involving WDR87
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR87 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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 |
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|  | Block miRNA regulation of human, mouse, rat WDR87 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing WDR87 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR87 | | Predesigned siRNA for gene silencing in human, mouse, rat WDR87 | | | QuantiFast Probe-based Assays in human, mouse, rat WDR87 | | QuantiTect SYBR Green Assays in human, mouse, rat WDR87 | | | Custom PCR Arrays for WDR87 | | Search Chromatin IP Primers for WDR87 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat WDR87 | | Search GeneGlobe Interaction Network for WDR87 | | | Search Regulatory tfbs for WDR87 |
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 |  |  |  | |
| | | Search Tocris compounds for WDR87 |
| | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR87 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for WDR87 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat WDR87 |
| | | | LSBio Antibodies in human, mouse, rat for WDR87 |
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