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WDR86 Gene

protein-coding   GIFtS: 49
GCID: GC07M151072

WD Repeat Domain 86

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
WD Repeat Domain 861 2
WD Repeat-Containing Protein 862

External Ids:    HGNC: 280201   Entrez Gene: 3491362   Ensembl: ENSG000001872607   UniProtKB: Q86TI43   
ORGUL members:         

Export aliases for WDR86 gene to outside databases

Previous GC identifers: GC07M150709 GC07M144889


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR86 Gene:
WDR86 (WD repeat domain 86) is a protein-coding gene. Diseases associated with WDR86 include coronary heart disease. An important paralog of this gene is FBXW7.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR86 gene promoter:
         AML1a   FOXD3   Lmo2   CUTL1   Ik-3   C/EBPalpha   GATA-1   Sox9   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): WDR86 promoter sequence
   Search Chromatin IP Primers for WDR86

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR86


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

WDR86 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR86 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M151072:  view genomic region     (about GC identifiers)

Start:
151,072,995 bp from pter      End:
151,107,813 bp from pter
Size:
34,819 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 150,407,571-150,436,711     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR86_HUMAN, Q86TI4 (See protein sequence)
Recommended Name: WD repeat-containing protein 86  
Size: 376 amino acids; 40731 Da
Sequence caution: Sequence=AAI07126.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3KNT1 Q6ZUS8
Alternative splicing: 3 isoforms:  Q86TI4-3   Q86TI4-1   Q86TI4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR86: NX_Q86TI4

Explore proteomics data for WDR86 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR86 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001271189.1  NP_001271190.1  NP_001271191.1  NP_938026.2  

    ENSEMBL proteins: 
     ENSP00000335522   ENSP00000417512   ENSP00000419162  

    WDR86 Human Recombinant Protein Products:

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    WDR86 Assay Products:

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    Cloud-Clone Corp. CLIAs for WDR86


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR018391 PQQ_beta_propeller_repeat
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep

    Graphical View of Domain Structure for InterPro Entry Q86TI4

    ProtoNet protein and cluster: Q86TI4

    1 Blocks protein domain: IPB002372 Bacterial quinoprotein

    UniProtKB/Swiss-Prot: WDR86_HUMAN, Q86TI4
    Similarity: Contains 8 WD repeats


    WDR86 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR86 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR86:
     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR86
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR86
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR86

    miRNA
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    miRTarBase miRNAs that target WDR86:
    hsa-mir-335-5p (MIRT019212)

    Block miRNA regulation of human, mouse, rat WDR86 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate WDR86:
    hsa-miR-214 hsa-miR-205* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidWDR86 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDR86
    Predesigned siRNA for gene silencing in human, mouse, rat WDR86

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR86


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR86
    Interactions:

        Search GeneGlobe Interaction Network for WDR86

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for WDR86 (ENSP000003355224) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC6ENSP000002097284STRING: ENSP00000209728
    PSMD8ENSP000002150714STRING: ENSP00000215071
    PSMD2ENSP000003101294STRING: ENSP00000310129
    ATP6V1AENSP000002733984STRING: ENSP00000273398
    DDI1ENSP000003028054STRING: ENSP00000302805
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR86



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR86 gene (4 alternative transcripts): 
    NM_001284260.1  NM_001284261.1  NM_001284262.1  NM_198285.2  

    Unigene Cluster for WDR86:

    WD repeat domain 86
    Hs.647083  [show with all ESTs]
    Unigene Representative Sequence: BC047921
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463000 ENST00000334493(uc003wkb.2 uc011kvk.1) ENST00000477459(uc003wkc.2)
    ENST00000469830 ENST00000484630 ENST00000496971
    miRNA
    Products:
         
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    3 qRT-PCR Assays for microRNAs that regulate WDR86:
    hsa-miR-214 hsa-miR-205* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidWDR86 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR86
    Predesigned siRNA for gene silencing in human, mouse, rat WDR86
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR86 (NM_198285)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR86
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR86
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR86
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR86
      QuantiTect SYBR Green Assays in human, mouse, rat WDR86
      QuantiFast Probe-based Assays in human, mouse, rat WDR86

    Additional mRNA sequence: 

    AK125347.1 AK296049.1 AK301628.1 BC047921.1 BC107125.2 BC128098.1 

    8 DOTS entries:

    DT.100777340  DT.40281644  DT.100770816  DT.91954377  DT.214240  DT.429335  DT.100819293  DT.40239335 

    Selected AceView cDNA sequences (see all 54):

    CR608177 AA991591 AA861330 AI131078 AI670120 BM889538 BG055818 BI521330 
    AI349501 BX338490 BM681903 AI694442 BI757623 NM_198285 AA693322 AW269414 
    BX089412 AA025867 AK125347 AI191676 BF345774 AW293552 AK096225 BC047921 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR86    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                                                
    SP2:              -     -     -     -     -     -     -                       -                     
    SP3:                    -     -           -                                                         
    SP4:                                      -     -     -                                             


    ECgene alternative splicing isoforms for WDR86

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR86 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCGCCGAC
    WDR86 Expression
    About this image

    WDR86 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR86 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647083
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR86

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR86 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr861 , 5 WD repeat domain 861, 5 84.57(n)1
    88.03(a)1
      5 (11.93 cM)5
    2696331  NM_001081441.11  NP_001074910.11 
     247117385 
    chicken
    (Gallus gallus)
    Aves WDR861 WD repeat domain 86 71.56(n)
    71.2(a)
      770203  XM_001233534.3  XP_001233535.2 
    lizard
    (Anolis carolinensis)
    Reptilia WDR866
    WD repeat domain 86
    64(a)
    1 ↔ 1
    6(3890653-3909064)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr861 WD repeat domain 86 65.67(n)
    63.86(a)
      100486668  XM_002932493.2  XP_002932539.2 
    zebrafish
    (Danio rerio)
    Actinopterygii znf106b6
    si:ch211-154o6.36
    (see all 3)
    si:ch211-154o6.3
    (see all 3)
    7(a)
    13(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    20(25965977-25990984) ENSDARG00000091947
    16(23745585-23773662) ENSDARG00000090538
    fruit fly
    (Drosophila melanogaster)
    Insecta CG143226
    --
    4(a)
    1 → many
    3R(13473401-13495048)


    ENSEMBL Gene Tree for WDR86 (if available)
    TreeFam Gene Tree for WDR86 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR86 gene
    FBXW72  TRAF72  BTRC2  FBXW22  FBXW112  ZNF1062  
    8 SIMAP similar genes for WDR86 using alignment to 3 protein entries:     WDR86_HUMAN (see all proteins):
    LOC349136    GNB5    PF20    WDR83    WSB1    FBXW7
    DAW1    WDR38

    WDR86 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR86 (see all 702)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132424671,2
    C,F,H--151077794(+) TCTGGC/TGTGTG 1 -- ds500114Minor allele frequency- T:0.16EA NS NA CSA 1877
    rs2011237271,2
    --151077794(+) TCTGG-/CATGTGT 1 -- ds50010--------
    rs102767231,2
    C,A,H--151077795(+) CTGGCG/ATGTGT 1 -- ds50016Minor allele frequency- A:0.12WA CSA NA EA 363
    rs1438117311,2
    C--151077869(+) GCCCG-/CCCCCA 1 -- ds50010--------
    rs1494157851,2
    C--151077916(+) AGATT-/CATGCC
    AGAAAATGA
    CATGC
    1 -- ds50010--------
    rs624902811,2
    F--151078071(+) CACCCA/CCAAGT 1 -- ds50012Minor allele frequency- C:0.04NA 122
    rs1155846281,2
    C,F--151078154(+) CCCAAG/CCTCCA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs22864181,2
    C,F,H--151078218(-) CCTGAA/GCGTTA 1 -- ut3115Minor allele frequency- G:0.06EA NS NA 2950
    rs1461598431,2
    --151078353(+) GAGCTA/GGGGCA 1 -- ut310--------
    rs22864171,2
    C,F--151078371(-) CAGGGG/CCTGCA 1 -- ut31 ese35Minor allele frequency- C:0.31EA NA 960

    HapMap Linkage Disequilibrium report for WDR86 (151072995 - 151107813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR86:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6005CNV Insertion18451855
    esv1308328CNV Insertion17803354
    nsv889489CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing WDR86
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR86

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for WDR86:    
    About MalaCards
    coronary heart disease


    WDR86 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR86

    Export disorders for WDR86 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR86 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with WDR86)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)4 Lettre G....Boerwinkle E. (PLoS Genet. 2011)
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 349136 HGNC: 28020 AceView: LOC349136 Ensembl:ENSG00000187260 euGenes: HUgn349136
    ECgene: WDR86 H-InvDB: WDR86

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    PharmGKB entry for WDR86 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR86 gene:
    Search GeneIP for patents involving WDR86

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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