WDR86 Gene
protein-coding GIFtS: 41
GCID: GC07M151072
|
|
WD repeat domain 86
| |
Aliases
for WDR86 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 861 2 | | WD Repeat-Containing Protein 862 |
Export aliases for WDR86 gene to outside databasesPrevious GC identifers: GC07M150709 GC07M144889 |
Summaries
for WDR86 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR86 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR86 gene promoter:
AML1a FOXD3 Lmo2 CUTL1 Ik-3 C/EBPalpha GATA-1 Sox9 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR86
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR86 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1WDR86 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M151072: view genomic region
(about GC identifiers)
Start:
|
151,072,995 bp from pter |
End:
|
151,107,813 bp from pter |
Size:
|
34,819 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 150,407,571-150,436,711 |
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Proteins
for WDR86 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR86_HUMAN, Q86TI4 (See
protein sequence)Recommended Name: WD repeat-containing protein 86 Size: 376 amino acids; 40731 Da
Sequence caution: Sequence=AAI07126.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3KNT1 Q6ZUS8Alternative splicing: 3 isoforms: Q86TI4-3 Q86TI4-1 Q86TI4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR86: NX_Q86TI4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86TI4
WDR86 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_938026.2
ENSEMBL proteins: ENSP00000395972 ENSP00000335522 ENSP00000417512 ENSP00000419162
Human Recombinant Protein Products for WDR86:
WDR86 Antibody Products:
Assay Products for WDR86: |
Protein
Domains /
Families
for WDR86 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR86 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q86TI4ProtoNet protein and cluster: Q86TI4 1 Blocks protein family: IPB002372 Bacterial quinoprotein
UniProtKB/Swiss-Prot: WDR86_HUMAN, Q86TI4Similarity: Contains 8 WD repeats |
Function
for WDR86 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for WDR86:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR86 (NM_198285) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR86 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR86 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR86 |
|
Pathways & Interactions
for WDR86 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR86
|
Drugs & Compounds
for WDR86 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR86
Search CenterWatch for drugs/clinical trials and news about WDR86
|
Transcripts
for WDR86 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR86 gene: NM_198285.2 Unigene Cluster for WDR86: WD repeat domain 86 Hs.647083 [show with all ESTs]Unigene Representative Sequence: BC0479217 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000463000 ENST00000445513(uc003wka.2) ENST00000334493(uc003wkb.2 uc011kvk.1)
ENST00000477459(uc003wkc.2) ENST00000469830 ENST00000484630 ENST00000496971
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR86 (NM_198285) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR86 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR86 |
Additional cDNA sequence: AK125347.1 AK296049.1 AK301628.1 BC047921.1 BC107125.2 BC128098.1 6 DOTS entries: DT.100777340 DT.40281644 DT.100770816 DT.429335 DT.91954377 DT.40239335 24/54 AceView cDNA sequences (see all 54): BI521330 BG055818 BM889538 AA991591 AI131078 AA861330 AI670120 CR608177 AI168171 AW451264 AI349501 BM681903 AA025867 BF345774 BX371801 AK125347 BX089412 AI681150 AW293552 AI191676 BI757623 AI694442 BX111953 BQ028133
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR86 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR86
|
Expression
for WDR86 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR86 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCGCCGAC
About this image
See WDR86 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR86
SOURCE GeneReport for Unigene cluster: Hs.647083
SABiosciences Custom PCR Arrays for WDR86
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR86
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR86 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR86 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR86 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR86 |
Orthologs
for WDR86 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WDR86 gene from 2/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
WDR861 |
WD repeat domain 86 |
71.56(n)
71.2(a) |
|
770203 XM_001233534.2 XP_001233535.2 |
lizard
(Anolis carolinensis) |
Reptilia |
WDR866 |
-- |
68(a) |
1 ↔ 1 |
6(3902632-3908912) |
ENSEMBL Gene Tree for WDR86 (if available)
TreeFam Gene Tree for WDR86 (if available) |
Paralogs
for WDR86 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR86 gene
- FBXW72 TRAF72 BTRC2 FBXW22 ZNF1062 FBXW112
8 SIMAP similar genes for WDR86 using alignment to 4 protein entries: WDR86_HUMAN (see all proteins):LOC349136 GNB5 PF20 WDR83 WSB1 FBXW7
WDR69 WDR38
WDR86 for paralogs About GeneDecksing
|
Genomic Variants
for WDR86 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR86 (151072995 - 151107813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR86: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for WDR86 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR86 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR86 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR86) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
|
External Searches for WDR86 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR86 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR86 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR86 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR86 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR86 gene:
Search GeneIP for patents involving WDR86
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR86 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR86 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR86 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR86 | | | OriGene Protein Over-expression Lysate for WDR86 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR86 | | OriGene 3'-UTR Clone for WDR86 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR86 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR86 | | OriGene Custom Protein Services for WDR86 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR86 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR86 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR86 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR86 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR86 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR86 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for WDR86 |
| |  |  |  |  | | | | |
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 |
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 | | | WDR86 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR86 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for WDR86 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR86 |
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