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Aliases for WDR86 Gene

Aliases for WDR86 Gene

  • WD Repeat Domain 86 2 3 5

External Ids for WDR86 Gene

Previous GeneCards Identifiers for WDR86 Gene

  • GC07M150709
  • GC07M151072
  • GC07M144889

Summaries for WDR86 Gene

GeneCards Summary for WDR86 Gene

WDR86 (WD Repeat Domain 86) is a Protein Coding gene. An important paralog of this gene is TRAF7.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR86 Gene

Genomics for WDR86 Gene

Regulatory Elements for WDR86 Gene

Enhancers for WDR86 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G151424 1.3 Ensembl ENCODE 13.8 -17.1 -17116 6.5 HDGF ARNT SIN3A ARID4B FEZF1 ZNF2 ZNF143 FOS ZNF263 REST WDR86 ENSG00000241456 CRYGN WDR86-AS1 MIR3907
GH07G151365 1.3 Ensembl ENCODE 12.1 +43.6 43562 3.5 HDGF HNRNPUL1 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 WDR86-AS1 WDR86 CRYGN ENSG00000241456 RHEB SMARCD3 ENSG00000243018 NUB1 GC07M151365 GC07P151348
GH07G151379 1.2 Ensembl ENCODE 12.8 +29.4 29384 3.2 HDGF HNRNPUL1 PKNOX1 AGO1 SIN3A YBX1 ZNF2 GLIS2 KLF7 ZNF263 WDR86 WDR86-AS1 ENSG00000241456 CRYGN SMARCD3 ENSG00000243018 NUB1 GC07M151365 PIR52552
GH07G151408 0.9 ENCODE 14.7 +1.2 1173 3.1 ELF3 PKNOX1 ZSCAN4 ZNF76 KLF17 ZNF2 RAD21 RARA GLIS2 ZNF143 WDR86 ENSG00000241456 WDR86-AS1
GH07G151416 0.9 ENCODE 14.5 -6.2 -6183 0.9 HDAC1 HDGF ATF1 PKNOX1 TBL1XR1 SIN3A FEZF1 RAD21 TCF12 GATA2 WDR86 WDR86-AS1 ENSG00000241456
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR86 on UCSC Golden Path with GeneCards custom track

Promoters for WDR86 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for WDR86 Gene

151,375,909 bp from pter
151,410,727 bp from pter
34,819 bases
Minus strand

Genomic View for WDR86 Gene

Genes around WDR86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR86 Gene

Proteins for WDR86 Gene

  • Protein details for WDR86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 86
    Protein Accession:
    Secondary Accessions:
    • B4DJF1
    • C9JAJ5
    • C9JXE3
    • Q3KNT1
    • Q6ZUS8

    Protein attributes for WDR86 Gene

    376 amino acids
    Molecular mass:
    40731 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI07126.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR86 Gene


neXtProt entry for WDR86 Gene

Post-translational modifications for WDR86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR86 Gene

Domains & Families for WDR86 Gene

Gene Families for WDR86 Gene

Suggested Antigen Peptide Sequences for WDR86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR86: view

No data available for UniProtKB/Swiss-Prot for WDR86 Gene

Function for WDR86 Gene

genes like me logo Genes that share phenotypes with WDR86: view

Animal Model Products

CRISPR Products

miRNA for WDR86 Gene

miRTarBase miRNAs that target WDR86

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR86 Gene

Localization for WDR86 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR86 gene
Compartment Confidence
mitochondrion 2
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR86 Gene

Pathways & Interactions for WDR86 Gene

SuperPathways for WDR86 Gene

No Data Available

Interacting Proteins for WDR86 Gene

Gene Ontology (GO) - Biological Process for WDR86 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR86 Gene

Drugs & Compounds for WDR86 Gene

No Compound Related Data Available

Transcripts for WDR86 Gene

Unigene Clusters for WDR86 Gene

WD repeat domain 86:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR86 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP2: - - - - - - - -
SP3: - - -
SP4: - - -

Relevant External Links for WDR86 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR86 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR86 Gene

mRNA differential expression in normal tissues according to GTEx for WDR86 Gene

This gene is overexpressed in Thyroid (x5.3), Cervix - Endocervix (x5.1), Nerve - Tibial (x4.8), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for WDR86 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR86 Gene

Protein tissue co-expression partners for WDR86 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR86 Gene:


SOURCE GeneReport for Unigene cluster for WDR86 Gene:

genes like me logo Genes that share expression patterns with WDR86: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR86 Gene

Orthologs for WDR86 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR86 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR86 34 35
  • 98.85 (n)
(Bos Taurus)
Mammalia WDR86 34 35
  • 90.24 (n)
(Canis familiaris)
Mammalia WDR86 34 35
  • 90.2 (n)
(Mus musculus)
Mammalia Wdr86 34 16 35
  • 84.57 (n)
(Ornithorhynchus anatinus)
Mammalia WDR86 35
  • 66 (a)
(Monodelphis domestica)
Mammalia WDR86 35
  • 54 (a)
(Gallus gallus)
Aves WDR86 34 35
  • 71.56 (n)
(Anolis carolinensis)
Reptilia WDR86 35
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr86 34
  • 65.67 (n)
(Danio rerio)
Actinopterygii si:ch211-154o6.3 35 35
  • 13 (a)
znf106b 35
  • 7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14322 35
  • 4 (a)
Species where no ortholog for WDR86 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR86 Gene

Gene Tree for WDR86 (if available)
Gene Tree for WDR86 (if available)

Paralogs for WDR86 Gene

(8) SIMAP similar genes for WDR86 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR86: view

Variants for WDR86 Gene

Sequence variations from dbSNP and Humsavar for WDR86 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000022998 -- 151,402,864(+) GGGGC(C/T)CTCAG intron-variant
rs1000045468 -- 151,388,192(+) TTTCT(C/T)TTCTC intron-variant
rs1000077011 -- 151,407,731(+) AGCTA(A/T)TCAGG intron-variant, upstream-variant-2KB
rs1000171408 -- 151,392,204(+) TGCAG(A/C)CTGAT intron-variant
rs1000225913 -- 151,400,474(+) CCTCC(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR86 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
dgv3993e59 CNV duplication 20981092
esv1308328 CNV insertion 17803354
esv3542659 CNV deletion 23714750
nsv1067934 OTHER inversion 25765185
nsv1117769 CNV deletion 24896259
nsv1151906 OTHER inversion 26484159
nsv6005 CNV insertion 18451855

Variation tolerance for WDR86 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR86 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR86 Gene

Disorders for WDR86 Gene

Relevant External Links for WDR86

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR86 Gene

Publications for WDR86 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 46 64
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for WDR86 Gene

Sources for WDR86 Gene

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