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Aliases for WDR86 Gene

Aliases for WDR86 Gene

  • WD Repeat Domain 86 2 3 5

External Ids for WDR86 Gene

Previous GeneCards Identifiers for WDR86 Gene

  • GC07M150709
  • GC07M151072
  • GC07M144889

Summaries for WDR86 Gene

GeneCards Summary for WDR86 Gene

WDR86 (WD Repeat Domain 86) is a Protein Coding gene. An important paralog of this gene is TRAF7.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR86 Gene

Genomics for WDR86 Gene

Regulatory Elements for WDR86 Gene

Enhancers for WDR86 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR86 on UCSC Golden Path with GeneCards custom track

Promoters for WDR86 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR86 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR86 Gene

Chromosome:
7
Start:
151,375,909 bp from pter
End:
151,410,727 bp from pter
Size:
34,819 bases
Orientation:
Minus strand

Genomic View for WDR86 Gene

Genes around WDR86 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR86 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR86 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR86 Gene

Proteins for WDR86 Gene

  • Protein details for WDR86 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TI4-WDR86_HUMAN
    Recommended name:
    WD repeat-containing protein 86
    Protein Accession:
    Q86TI4
    Secondary Accessions:
    • B4DJF1
    • C9JAJ5
    • C9JXE3
    • Q3KNT1
    • Q6ZUS8

    Protein attributes for WDR86 Gene

    Size:
    376 amino acids
    Molecular mass:
    40731 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI07126.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR86 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR86 Gene

Proteomics data for WDR86 Gene at MOPED

Post-translational modifications for WDR86 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR86 Gene

Domains & Families for WDR86 Gene

Gene Families for WDR86 Gene

Suggested Antigen Peptide Sequences for WDR86 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TI4

UniProtKB/Swiss-Prot:

WDR86_HUMAN :
  • Contains 8 WD repeats.
Similarity:
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with WDR86: view

Function for WDR86 Gene

genes like me logo Genes that share phenotypes with WDR86: view

Animal Model Products

CRISPR Products

miRNA for WDR86 Gene

miRTarBase miRNAs that target WDR86

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR86 Gene

Localization for WDR86 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR86 Gene COMPARTMENTS Subcellular localization image for WDR86 gene
Compartment Confidence
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR86 Gene

Pathways & Interactions for WDR86 Gene

SuperPathways for WDR86 Gene

No Data Available

Interacting Proteins for WDR86 Gene

Gene Ontology (GO) - Biological Process for WDR86 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR86 Gene

Drugs & Compounds for WDR86 Gene

No Compound Related Data Available

Transcripts for WDR86 Gene

Unigene Clusters for WDR86 Gene

WD repeat domain 86:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR86 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: - - - - - - - -
SP3: - - -
SP4: - - -

Relevant External Links for WDR86 Gene

GeneLoc Exon Structure for
WDR86
ECgene alternative splicing isoforms for
WDR86

Expression for WDR86 Gene

mRNA expression in normal human tissues for WDR86 Gene

mRNA differential expression in normal tissues according to GTEx for WDR86 Gene

This gene is overexpressed in Thyroid (x5.3), Cervix - Endocervix (x5.1), Nerve - Tibial (x4.8), and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for WDR86 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR86 Gene



SOURCE GeneReport for Unigene cluster for WDR86 Gene Hs.647083

genes like me logo Genes that share expression patterns with WDR86: view

Protein tissue co-expression partners for WDR86 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR86 Gene

Orthologs for WDR86 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR86 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR86 35
  • 90.24 (n)
  • 90.79 (a)
WDR86 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR86 35
  • 90.2 (n)
  • 91.98 (a)
WDR86 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr86 35
  • 84.57 (n)
  • 88.03 (a)
Wdr86 16
Wdr86 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR86 35
  • 98.85 (n)
  • 99.2 (a)
WDR86 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR86 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR86 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR86 35
  • 71.56 (n)
  • 71.2 (a)
WDR86 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR86 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr86 35
  • 65.67 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-154o6.3 36
  • 13 (a)
ManyToMany
si:ch211-154o6.3 36
  • 12 (a)
ManyToMany
znf106b 36
  • 7 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14322 36
  • 4 (a)
OneToMany
Species with no ortholog for WDR86:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR86 Gene

ENSEMBL:
Gene Tree for WDR86 (if available)
TreeFam:
Gene Tree for WDR86 (if available)

Paralogs for WDR86 Gene

(8) SIMAP similar genes for WDR86 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR86: view

Variants for WDR86 Gene

Sequence variations from dbSNP and Humsavar for WDR86 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs4141455 - 151,381,649(-) GCCCA(C/T)GCGCA intron-variant, reference, synonymous-codon, missense
rs877155 -- 151,404,167(+) GCAAA(C/T)TGATA intron-variant, utr-variant-5-prime
rs877156 -- 151,404,454(+) CCCAA(C/T)CCCTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs887406 -- 151,404,458(-) AACAT(A/G)GGGGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001836 -- 151,403,498(-) GGGTC(A/G)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR86 Gene

Variant ID Type Subtype PubMed ID
nsv889489 CNV Loss 21882294
nsv6005 CNV Insertion 18451855
esv1308328 CNV Insertion 17803354

Variation tolerance for WDR86 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.73; 78.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR86 Gene

Disorders for WDR86 Gene

Relevant External Links for WDR86

Genetic Association Database (GAD)
WDR86
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR86

No disorders were found for WDR86 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR86 Gene

Publications for WDR86 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for WDR86 Gene

Sources for WDR86 Gene

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