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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR85 Gene

protein-coding   GIFtS: 46
GCID: GC09M140449

WD repeat domain 85

(Previous name: chromosome 9 open reading frame 112 )
(Previous symbol: C9orf112)
 Explore 3 diseases affiliated with
WDR85 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for WDR85    

Aliases
for WDR85 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
WD Repeat Domain 851 2     Chromosome 9 Open Reading Frame 1121
C9orf1121 2 3     RP11-48C7.32
RRT21 2     WD Repeat-Containing Protein 852
FLJ906341     

External Ids:    HGNC: 251991   Entrez Gene: 927152   Ensembl: ENSG000001483997   OMIM: 6132105   UniProtKB: Q9BTV63   

Export aliases for WDR85 gene to outside databases

Previous GC identifers: GC09M139569 GC09M109913


Summaries
for WDR85 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WDR85:
WDR85 is a WD repeat-containing protein that plays a role in the first step of diphthamide biosynthesis (Carette et
al., 2009 (PubMed 19965467)).(supplied by OMIM, Feb 2010)

UniProtKB/Swiss-Prot: WDR85_HUMAN, Q9BTV6
Function: Plays a role in the first step of diphthamide biosynthesis, a post-translational modification of histidine
which occurs in translation elongation factor 2 which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas
exotoxin A




Genomic Views
for WDR85 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_024000.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR85 gene promoter:
         MEF-2A   STAT1   Tal-1   Pbx1a   COMP1   aMEF-2   Zic3   HNF-4alpha1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR85 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR85

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR85


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

WDR85 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR85 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M140449:  view genomic region     (about GC identifiers)

Start:
 140,449,356 bp from pter      End:
 140,473,387 bp from pter
Size:
 24,032 bases      Orientation:
 minus strand

Proteins
for WDR85 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: WDR85_HUMAN, Q9BTV6 (See protein sequence)
Recommended Name: WD repeat-containing protein 85  
Size: 452 amino acids; 50575 Da
Secondary accessions: Q96AB7

Explore the universe of human proteins at neXtProt for WDR85: NX_Q9BTV6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BTV6

    • WDR85 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_620133.1  
    ENSEMBL proteins: 
     ENSP00000277540  

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    Uscn Proteins for WDR85


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    Uscn ELISAs and CLIAs for WDR85

    Protein Domains /
    Families
    for WDR85 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    WDR85 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BTV6

    ProtoNet protein and cluster: Q9BTV6

    UniProtKB/Swiss-Prot: WDR85_HUMAN, Q9BTV6
    Similarity: Belongs to the WD repeat WDR85 family
    Similarity: Contains 3 WD repeats


    Function
    for WDR85 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: WDR85_HUMAN, Q9BTV6
    Function: Plays a role in the first step of diphthamide biosynthesis, a post-translational modification of histidine
    which occurs in translation elongation factor 2 which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas
    exotoxin A

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: WDR85 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR85 (see all 4)
    OriGene shRNA RFP: WDR85
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR85 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR85 

    Cell Line
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    Search LifeMap BioReagents cell lines for WDR85

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR85


    Pathways & Interactions
    for WDR85 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR85

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for WDR85 (Q9BTV63 ENSP000002775404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L1Q132573I2D: score=5 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017183peptidyl-diphthamide biosynthetic process from peptidyl-histidine IMP19965467


    WDR85 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WDR85 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR85
    Search CenterWatch for drugs/clinical trials and news about WDR85 

    Transcripts
    for WDR85 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WDR85 gene: 
    NM_138778.2  

    Unigene Cluster for WDR85:

    WD repeat domain 85
    Hs.292570  [show with all ESTs]
    Unigene Representative Sequence: BX647531
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000467243(uc004cnj.1) ENST00000479650(uc004cnm.1) ENST00000277540(uc004cnk.1)
    ENST00000497237(uc010ncl.1) ENST00000475100 ENST00000472113(uc022bql.1 uc022bqk.1)
    ENST00000485189 ENST00000467768 ENST00000477690 ENST00000470855 ENST00000481839
    ENST00000476303 ENST00000460572 ENST00000491359

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR85
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    SwitchGear 3'UTR luciferase reporter plasmid: WDR85 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: WDR85
    OriGene siRNA: WDR85
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR85
    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR85

    Additional cDNA sequence: 

    AJ420445.1 AK075115.1 AK094389.1 AK307180.1 AK308998.1 AK310226.1 AK310987.1 BC003123.1 
    BC016349.1 BC017335.2 BC040173.1 BX647531.1 

    20 DOTS entries:

    DT.100036955  DT.413431  DT.91752638  DT.99952822  DT.95188437  DT.100795933  DT.121150928  DT.100795936 
    DT.95188436  DT.100722693  DT.121150893  DT.97762599  DT.95188450  DT.95361736  DT.100795932  DT.99949784 
    DT.99996296  DT.100767123  DT.100795935  DT.99971356 

    24/198 AceView cDNA sequences (see all 198):

    AI694260 AI590942 Z45478 AA911359 BM824266 BX098249 BE206813 BM910837 
    BQ930021 BC017335 Z41176 BM799048 BF881947 CR597738 BC003123 CR621191 
    AI871163 AI871162 AI049519 BG778386 CA424073 BM975452 BQ962551 AI673051 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR85    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:        -     -                 -                                       
    SP3:                                                                        


    ECgene alternative splicing isoforms for WDR85

    Expression
    for WDR85 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR85 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    WDR85 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeVentral Foregut EndodermGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See WDR85 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR85

    SOURCE GeneReport for Unigene cluster: Hs.292570
        SABiosciences Custom PCR Arrays for WDR85
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR85

    Orthologs
    for WDR85 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR85 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wdr851 , 5 WD repeat domain 851, 5 74.52(n)1
    69.11(a)1    		   2 (16.87 cM)5
    672281  NM_026044.31  NP_080320.11 
     249624005 
    chicken
    (Gallus gallus)    		 Aves WDR851 WD repeat domain 85 60.75(n)
    55.01(a)    		   417262  XM_415537.3  XP_415537.3 
    lizard
    (Anolis carolinensis)    		 Reptilia WDR856
    		 --
    		 51(a)
    		 1 ↔ 1
    		 AAWZ02039217(862-7894)
    zebrafish
    (Danio rerio)    		 Actinopterygii wdr851 WD repeat domain 85 56.33(n)
    53.61(a)    		   564032  NM_001082839.1  NP_001076308.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG31841 CG3184 49.31(n)
    41.53(a)    		   31608  NM_132113.3  NP_572341.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y43F4B.96
    		 --
    		 24(a)
    		 1 ↔ 1
    		 III(13314987-13318501)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G630101 transducin/WD40 domain-containing protein 46.44(n)
    39.32(a)    		   836421  NM_125695.2  NP_201106.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g05079001 hypothetical protein 50.86(n)
    41.92(a)    		   4336350  NM_001059801.1  NP_001053266.1 


    ENSEMBL Gene Tree for WDR85 (if available)
    TreeFam Gene Tree for WDR85 (if available) 

    Paralogs
    for WDR85 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for WDR85 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/69 NCBI SNPs in WDR85 are shown (see all 69)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1126718261,2
    		C,--109923828(+) TCCCCG/TGGGTG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs111371331,2
    		C,F,--109923856(+) TCCCCT/GGGGTG 1 -- int13Minor allele frequency- G:0.33NA 6
    rs1885680801,2
    		--140455216(+) GGCAGA/GAGAAT 1 -- int10--------
    rs8213191,2
    		C--140459782(-) CACCCC/AGGGGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs120059061,2
    		C,H--140459792(+) GACTGA/TCTGTG 1 -- int10--------
    rs94100311,2
    		C--140459884(+) CTGTCC/TGTGAG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs563855331,2
    		C--140460550(+) CTGGGC/TGACTC 1 -- int10--------
    rs341368781,2
    		C,--140473994(+) CGCCG-/CCCCCC 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1136408851,2
    		----140459824(+) CTGTCC/TGTGAG 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1438826981,2
    		----140459761(+) GTGAC-/CTTGTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for WDR85 (140449356 - 140473387 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for WDR85
         2 CNVs: 70850 23896

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR85
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    Disorders / Diseases
    for WDR85 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    WDR85 for disorders           About GeneDecksing

    OMIM gene information: 613210    OMIM disorders: --

    3 diseases for WDR85:    About MalaCards
    diphtheria    retinoblastoma    malaria

    Human Genome Epidemiology (HuGE) Navigator: WDR85 (1 document)

    Export disorders for WDR85 gene to outside databases

    Publications
    for WDR85 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR85 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR85)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Haploid genetic screens in human cells identify host factors used by pathogens. (PubMed id 19965467)1, 2 Carette J.E....Brummelkamp T.R. (2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    External Searches for WDR85 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing WDR85 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92715 HGNC: 25199 AceView: C9orf112 Ensembl:ENSG00000148399 euGenes: HUgn92715
    ECgene: WDR85 H-InvDB: WDR85

    Other Databases showing WDR85 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing WDR85 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR85 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR85 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WDR85 gene:
    Search GeneIP for patents involving WDR85

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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