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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR83OS Gene

protein-coding   GIFtS: 38
GCID: GC19M012779

WD Repeat Domain 83 Opposite Strand

(Previous name: chromosome 19 open reading frame 56)
(Previous symbol: C19orf56)
  Search for WDR83OS
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 83 Opposite Strand1 2 3     PTD0082
C19orf561 2     Protein Asterix2
WDR83 Opposite Strand2 3     UPF0139 Membrane Protein C19orf562
Chromosome 19 Open Reading Frame 561     

External Ids:    HGNC: 302031   Entrez Gene: 513982   Ensembl: ENSG000001055837   UniProtKB: Q9Y2843   

Export aliases for WDR83OS gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR83OS Gene: 
WDR83OS (WD repeat domain 83 opposite strand) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for WDR83OS
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR83OS promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR83OS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR83OS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

WDR83OS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR83OS gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012779:  view genomic region     (about GC identifiers)

Start:
12,778,881 bp from pter      End:
12,782,170 bp from pter
Size:
3,290 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ASTER_HUMAN, Q9Y284 (See protein sequence)
Recommended Name: Protein Asterix  
Size: 106 amino acids; 12068 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R4T8 Q9BVI3

Explore the universe of human proteins at neXtProt for WDR83OS: NX_Q9Y284

Explore proteomics data for WDR83OS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y284

  • WDR83OS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR83OS Protein Expression
    REFSEQ proteins: NP_057229.1  
    ENSEMBL proteins: 
     ENSP00000468969   ENSP00000222190   ENSP00000471797  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    WDR83OS for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005351 UPF0139

    Graphical View of Domain Structure for InterPro Entry Q9Y284

    ProtoNet protein and cluster: Q9Y284

    1 Blocks protein domain: IPB005351 Protein of unknown function UPF0139

    UniProtKB/Swiss-Prot: ASTER_HUMAN, Q9Y284
    Similarity: Belongs to the Asterix family


    WDR83OS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for WDR83OS:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR83OS

    1 Interacting protein for WDR83OS (Q9Y2843) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHTKD1Q96HY73I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR83OS (ASTER)

    Search CenterWatch for drugs/clinical trials and news about WDR83OS / ASTER

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR83OS gene: 
    NM_016145.3  

    Unigene Cluster for WDR83OS:

    WD repeat domain 83 opposite strand
    Hs.108969  [show with all ESTs]
    Unigene Representative Sequence: BU506766
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596731 ENST00000222190(uc002mud.2) ENST00000598732 ENST00000600694

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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of WDR83OS 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR83OS
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    Additional mRNA sequence: 

    AF059620.1 AF078861.1 AF151898.1 AK311944.1 BC001192.1 BC042919.1 BC061912.1 

    18 DOTS entries:

    DT.120292  DT.121449434  DT.100829411  DT.455210  DT.100868759  DT.87016627  DT.95224094  DT.100038904 
    DT.121449252  DT.100868760  DT.101979173  DT.92439192  DT.100038909  DT.121449223  DT.92439189  DT.92439194 
    DT.121449421  DT.91724126 

    24/935 AceView cDNA sequences (see all 935):

    BQ679975 BU553831 BQ286032 BC000736 AI023128 BI195420 BU733233 AA888906 
    BM843971 BF796255 AW304225 BX280941 BU931269 BU730646 AI720901 BP373779 
    BC061912 AA188345 BQ440261 BM854658 AI074441 BM783587 BU785357 CD367955 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WDR83OS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for WDR83OS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR83OS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTAGGGG
    WDR83OS Expression
    About this image


    See WDR83OS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR83OS

    SOURCE GeneReport for Unigene cluster: Hs.108969
        SABiosciences Custom PCR Arrays for WDR83OS
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR83OS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDR83OS gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0564741 , 5 cDNA sequence BC0564741, 5 91.82(n)1
    100(a)1
      8 (41.55 cM)5
    4140771  NM_001001493.21  NP_001001493.11 
     850807405 
    chicken
    (Gallus gallus)
    Aves WDR83OS6
    Protein Asterix
    89(a)
    1 ↔ 1
    AADN03018792.1(21-1947)
    lizard
    (Anolis carolinensis)
    Reptilia WDR83OS6
    Uncharacterized protein
    91(a)
    1 ↔ 1
    GL343286.1(724232-740173)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:731111 zgc:73111 76.1(n)
    87.74(a)
      393689  NM_200716.1  NP_957010.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG106741 CG10674 65.7(n)
    68.93(a)
      38602  NM_139693.2  NP_647950.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K10B2.41 Protein K10B2.4 62.96(n)
    66.67(a)
      174054  NM_062880.4  NP_495281.1 


    ENSEMBL Gene Tree for WDR83OS (if available)
    TreeFam Gene Tree for WDR83OS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in WDR83OS are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0524984
    ----see VAR_0524982 P A mis40--------

    HapMap Linkage Disequilibrium report for WDR83OS (12778881 - 12782170 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WDR83OS: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR83OS
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR83OS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR83OS gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR83OS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51398 HGNC: 30203 AceView: MAN2B1andPTD008andLOC284393 Ensembl:ENSG00000105583 euGenes: HUgn51398
    ECgene: WDR83OS H-InvDB: WDR83OS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR83OS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR83OS gene:
    Search GeneIP for patents involving WDR83OS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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