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Aliases for WDR83 Gene

Aliases for WDR83 Gene

  • WD Repeat Domain 83 2 3 5
  • MAPK Organizer 1 2 3 4
  • Mitogen-Activated Protein Kinase Organizer 1 3 4
  • MORG1 3 4
  • WD Repeat Domain-Containing Protein 83 3

External Ids for WDR83 Gene

Previous GeneCards Identifiers for WDR83 Gene

  • GC19P012777
  • GC19P012350

Summaries for WDR83 Gene

Entrez Gene Summary for WDR83 Gene

  • This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

GeneCards Summary for WDR83 Gene

WDR83 (WD Repeat Domain 83) is a Protein Coding gene. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include kinase activity. An important paralog of this gene is WDR5B.

UniProtKB/Swiss-Prot for WDR83 Gene

  • Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR83 Gene

Genomics for WDR83 Gene

Regulatory Elements for WDR83 Gene

Enhancers for WDR83 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around WDR83 on UCSC Golden Path with GeneCards custom track

Promoters for WDR83 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for WDR83 Gene

Chromosome:
19
Start:
12,666,800 bp from pter
End:
12,675,832 bp from pter
Size:
9,033 bases
Orientation:
Plus strand

Genomic View for WDR83 Gene

Genes around WDR83 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR83 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR83 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR83 Gene

Proteins for WDR83 Gene

  • Protein details for WDR83 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRX9-WDR83_HUMAN
    Recommended name:
    WD repeat domain-containing protein 83
    Protein Accession:
    Q9BRX9
    Secondary Accessions:
    • B2RAF1
    • Q53FT6

    Protein attributes for WDR83 Gene

    Size:
    315 amino acids
    Molecular mass:
    34343 Da
    Quaternary structure:
    • Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.

neXtProt entry for WDR83 Gene

Post-translational modifications for WDR83 Gene

  • Ubiquitination at Lys 19, Lys 47, and Lys 50
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR83 Gene

No data available for DME Specific Peptides for WDR83 Gene

Domains & Families for WDR83 Gene

Gene Families for WDR83 Gene

Suggested Antigen Peptide Sequences for WDR83 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRX9

UniProtKB/Swiss-Prot:

WDR83_HUMAN :
  • Belongs to the WD repeat MORG1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat MORG1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR83: view

Function for WDR83 Gene

Molecular function for WDR83 Gene

UniProtKB/Swiss-Prot Function:
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for WDR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22365833
genes like me logo Genes that share ontologies with WDR83: view
genes like me logo Genes that share phenotypes with WDR83: view

Animal Models for WDR83 Gene

MGI Knock Outs for WDR83:

Animal Model Products

CRISPR Products

miRNA for WDR83 Gene

miRTarBase miRNAs that target WDR83

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR83 Gene

Localization for WDR83 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR83 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR83 Gene COMPARTMENTS Subcellular localization image for WDR83 gene
Compartment Confidence
nucleus 5
endosome 4
cytoskeleton 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for WDR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005681 spliceosomal complex IDA 11991638
GO:0005737 cytoplasm IEA --
GO:0010008 endosome membrane TAS --
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with WDR83: view

Pathways & Interactions for WDR83 Gene

SuperPathways for WDR83 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Developmental Biology
3 Immune System
4 Signaling by GPCR
5 MAP2K and MAPK activation
genes like me logo Genes that share pathways with WDR83: view

Pathways by source for WDR83 Gene

SIGNOR curated interactions for WDR83 Gene

Activates:

Gene Ontology (GO) - Biological Process for WDR83 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000375 RNA splicing, via transesterification reactions IDA 11991638
GO:0000398 mRNA splicing, via spliceosome IDA 11991638
genes like me logo Genes that share ontologies with WDR83: view

Drugs & Compounds for WDR83 Gene

No Compound Related Data Available

Transcripts for WDR83 Gene

Unigene Clusters for WDR83 Gene

WD repeat domain 83:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR83 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: - -

Relevant External Links for WDR83 Gene

GeneLoc Exon Structure for
WDR83
ECgene alternative splicing isoforms for
WDR83

Expression for WDR83 Gene

mRNA expression in normal human tissues for WDR83 Gene

Protein differential expression in normal tissues from HIPED for WDR83 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Tlymphocyte (26.1), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for WDR83 Gene



Protein tissue co-expression partners for WDR83 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR83 Gene:

WDR83

SOURCE GeneReport for Unigene cluster for WDR83 Gene:

Hs.657204
genes like me logo Genes that share expression patterns with WDR83: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR83 Gene

Orthologs for WDR83 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR83 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR83 34
  • 90.58 (n)
  • 95.24 (a)
MORG1 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR83 34
  • 89.95 (n)
  • 96.51 (a)
WDR83 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr83 34
  • 88.04 (n)
  • 93.97 (a)
Wdr83 16
Wdr83 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR83 34
  • 99.58 (n)
  • 99.68 (a)
WDR83 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr83 34
  • 87.2 (n)
  • 93.02 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR83 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR83 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR83 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr83 34
  • 72.4 (n)
  • 75.8 (a)
Str.2857 34
zebrafish
(Danio rerio)
Actinopterygii wdr83 34
  • 69.44 (n)
  • 73.72 (a)
wdr83 35
  • 73 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1078 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008129 34
  • 57.51 (n)
  • 48.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4935 34
  • 52.63 (n)
  • 48.42 (a)
CG4935 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F33G12.2 34
  • 49.49 (n)
  • 48.46 (a)
F33G12.2 35
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G64730 34
  • 52.03 (n)
  • 51.01 (a)
rice
(Oryza sativa)
Liliopsida Os02g0543400 34
  • 56.05 (n)
  • 49.66 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8158 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for WDR83 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR83 Gene

ENSEMBL:
Gene Tree for WDR83 (if available)
TreeFam:
Gene Tree for WDR83 (if available)

Paralogs for WDR83 Gene

Paralogs for WDR83 Gene

genes like me logo Genes that share paralogs with WDR83: view

Variants for WDR83 Gene

Sequence variations from dbSNP and Humsavar for WDR83 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_053410 -
VAR_053411 -
rs192581296 -- 12,671,741(+) TTGCC(A/C)GGCTG intron-variant
rs115095484 -- 12,672,324(+) GGGAA(C/G/T)TGGGC intron-variant
rs10406655 -- 12,672,004(+) aaaat(A/G)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR83 Gene

Variant ID Type Subtype PubMed ID
dgv138n111 CNV deletion 26073780
nsv1160586 CNV duplication 26073780
nsv472659 CNV novel sequence insertion 20440878
nsv953977 CNV deletion 24416366

Variation tolerance for WDR83 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.68; 32.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR83 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR83

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR83 Gene

Disorders for WDR83 Gene

Relevant External Links for WDR83

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR83

No disorders were found for WDR83 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR83 Gene

Publications for WDR83 Gene

  1. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. (PMID: 15118098) Vomastek T. … Weber M.J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 2 3 22 65
  2. The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3). (PMID: 16407229) Hopfer U. … Wolf G. (J. Biol. Chem. 2006) 2 3 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4 65
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3 65

Products for WDR83 Gene

Sources for WDR83 Gene

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