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Aliases for WDR82 Gene

Aliases for WDR82 Gene

  • WD Repeat Domain 82 2 3 5
  • Transmembrane Protein 113 2 3
  • TMEM113 3 4
  • WDR82A 3 4
  • SWD2 3 4
  • Protein TMEM113 4
  • PRO34047 3
  • MSTP107 3
  • PRO2730 3
  • MST107 3

External Ids for WDR82 Gene

Previous HGNC Symbols for WDR82 Gene

  • TMEM113

Previous GeneCards Identifiers for WDR82 Gene

  • GC03M096139
  • GC00U921977
  • GC03M052265

Summaries for WDR82 Gene

Entrez Gene Summary for WDR82 Gene

  • TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

GeneCards Summary for WDR82 Gene

WDR82 (WD Repeat Domain 82) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).

UniProtKB/Swiss-Prot for WDR82 Gene

  • Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR82 Gene

Genomics for WDR82 Gene

Regulatory Elements for WDR82 Gene

Enhancers for WDR82 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR82 on UCSC Golden Path with GeneCards custom track

Promoters for WDR82 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR82 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR82 Gene

Chromosome:
3
Start:
52,254,421 bp from pter
End:
52,288,020 bp from pter
Size:
33,600 bases
Orientation:
Minus strand

Genomic View for WDR82 Gene

Genes around WDR82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR82 Gene

Proteins for WDR82 Gene

  • Protein details for WDR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN9-WDR82_HUMAN
    Recommended name:
    WD repeat-containing protein 82
    Protein Accession:
    Q6UXN9
    Secondary Accessions:
    • A8K5R5
    • Q8TEB2

    Protein attributes for WDR82 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on Ser-5 of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.
    SequenceCaution:
    • Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for WDR82 Gene

Proteomics data for WDR82 Gene at MOPED

Post-translational modifications for WDR82 Gene

  • Ubiquitination at Lys 2, Lys 63, Lys 84, Lys 98, Lys 129, Lys 188, and Lys 280
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR82 Gene

Domains & Families for WDR82 Gene

Gene Families for WDR82 Gene

Suggested Antigen Peptide Sequences for WDR82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN9

UniProtKB/Swiss-Prot:

WDR82_HUMAN :
  • Belongs to the WD repeat SWD2 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat SWD2 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR82: view

Function for WDR82 Gene

Molecular function for WDR82 Gene

UniProtKB/Swiss-Prot Function:
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.
genes like me logo Genes that share phenotypes with WDR82: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR82 Gene

Localization for WDR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR82 Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR82 Gene COMPARTMENTS Subcellular localization image for WDR82 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0035097 histone methyltransferase complex IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view

Pathways & Interactions for WDR82 Gene

genes like me logo Genes that share pathways with WDR82: view

Pathways by source for WDR82 Gene

1 Cell Signaling Technology pathway for WDR82 Gene
1 KEGG pathway for WDR82 Gene

Gene Ontology (GO) - Biological Process for WDR82 Gene

None

No data available for SIGNOR curated interactions for WDR82 Gene

Drugs & Compounds for WDR82 Gene

No Compound Related Data Available

Transcripts for WDR82 Gene

Unigene Clusters for WDR82 Gene

WD repeat domain 82:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR82 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - - - -

Relevant External Links for WDR82 Gene

GeneLoc Exon Structure for
WDR82
ECgene alternative splicing isoforms for
WDR82

Expression for WDR82 Gene

mRNA expression in normal human tissues for WDR82 Gene

Protein differential expression in normal tissues from HIPED for WDR82 Gene

This gene is overexpressed in Lymph node (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR82 Gene



SOURCE GeneReport for Unigene cluster for WDR82 Gene Hs.194110

genes like me logo Genes that share expression patterns with WDR82: view

Protein tissue co-expression partners for WDR82 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR82 Gene

Orthologs for WDR82 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR82 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR82 35
  • 93.93 (n)
  • 100 (a)
WDR82P1 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR82 35
  • 94.46 (n)
  • 100 (a)
WDR82 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr82 35
  • 92.01 (n)
  • 100 (a)
Wdr82 16
Wdr82 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR82 35
  • 99.79 (n)
  • 100 (a)
WDR82 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr82 35
  • 92.76 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR82 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR82 35
  • 84.45 (n)
  • 97.76 (a)
WDR82 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR82 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr82 35
  • 79.45 (n)
  • 95.85 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr82 35
  • 80.19 (n)
  • 93.61 (a)
twf2a 36
  • 48 (a)
OneToMany
wdr82 36
  • 94 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009700 35
  • 64.95 (n)
  • 70.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wdr82 35
  • 62.73 (n)
  • 69.01 (a)
Wdr82 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swd-2.2 35
  • 50.55 (n)
  • 44.08 (a)
swd-2.1 36
  • 32 (a)
OneToMany
swd-2.2 36
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL099W 35
  • 44 (n)
  • 36.03 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18063g 35
  • 45.51 (n)
  • 36.54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD2 35
  • 45.9 (n)
  • 36.36 (a)
SWD2 36
  • 33 (a)
OneToOne
SWD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66240 35
  • 51.52 (n)
  • 41.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0589400 35
  • 50.16 (n)
  • 38.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07885 35
  • 44.88 (n)
  • 38.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes swd2 35
  • 48.65 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for WDR82:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR82 Gene

ENSEMBL:
Gene Tree for WDR82 (if available)
TreeFam:
Gene Tree for WDR82 (if available)

Paralogs for WDR82 Gene

(2) SIMAP similar genes for WDR82 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR82 Gene

genes like me logo Genes that share paralogs with WDR82: view

No data available for Paralogs for WDR82 Gene

Variants for WDR82 Gene

Sequence variations from dbSNP and Humsavar for WDR82 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1767 -- 52,256,458(+) AAAAA(C/G)GCTAA utr-variant-3-prime
rs1769 -- 52,256,534(+) TCTGA(A/G)GACTA utr-variant-3-prime
rs1060330 -- 52,254,929(-) CTCAC(A/G)GTCTC utr-variant-3-prime
rs770281 -- 52,282,822(-) acagg(C/T)gcaca intron-variant
rs812186 -- 52,281,576(-) atggt(A/G)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR82 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv460537 CNV Loss 19166990
nsv508218 CNV Loss 20534489
nsv508926 CNV Insertion 20534489
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv822090 CNV Gain 20364138

Variation tolerance for WDR82 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 1.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR82 Gene

Disorders for WDR82 Gene

Relevant External Links for WDR82

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR82

No disorders were found for WDR82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR82 Gene

Publications for WDR82 Gene

  1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PMID: 17355966) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2007) 2 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. WDR82 Negatively Regulates Cellular Antiviral Response by Mediating TRAF3 Polyubiquitination in Multiple Cell Lines. (PMID: 26519536) Zhu K. … Li L.Y. (J. Immunol. 2015) 3

Products for WDR82 Gene

Sources for WDR82 Gene

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