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Aliases for WDR82 Gene

Aliases for WDR82 Gene

  • WD Repeat Domain 82 2 3 5
  • Transmembrane Protein 113 2 3
  • TMEM113 3 4
  • WDR82A 3 4
  • SWD2 3 4
  • WD Repeat-Containing Protein 82 3
  • Protein TMEM113 4
  • PRO34047 3
  • MSTP107 3
  • PRO2730 3
  • MST107 3

External Ids for WDR82 Gene

Previous HGNC Symbols for WDR82 Gene

  • TMEM113

Previous GeneCards Identifiers for WDR82 Gene

  • GC03M096139
  • GC00U921977
  • GC03M052265

Summaries for WDR82 Gene

Entrez Gene Summary for WDR82 Gene

  • TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

GeneCards Summary for WDR82 Gene

WDR82 (WD Repeat Domain 82) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Chromatin Regulation / Acetylation. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).

UniProtKB/Swiss-Prot for WDR82 Gene

  • Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR82 Gene

Genomics for WDR82 Gene

Regulatory Elements for WDR82 Gene

Enhancers for WDR82 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052243 1.5 FANTOM5 ENCODE 13.6 +42.1 42135 4.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3 PBRM1 PPM1M LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03F053268 1.7 FANTOM5 Ensembl ENCODE 12 -982.1 -982081 4.2 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS KLF13 DEK PRKCD WDR82 ENSG00000207109 TKT SFMBT1 DCP1A GC03M053284 PIR47365
GH03F052236 1.4 FANTOM5 ENCODE 14.4 +49.2 49232 5.2 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 GLYCTK LOC101929054 RAD54L2 WDR82 NEK4 MIR135A1 GLYCTK-AS1 RRP9 TWF2 PPM1M
GH03F052044 1.8 FANTOM5 Ensembl ENCODE 10.3 +236.4 236398 14.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 ZNF143 GPR62 NT5DC2 RPL29 DUSP7 PCBP4 RAD54L2 WDR82 TWF2 ACY1 LOC105377089
GH03F052427 1.7 VISTA Ensembl ENCODE 10.5 -141.5 -141521 3.2 ATF1 MLX ARID4B DMAP1 ZNF48 SP5 ZHX2 REST PPARG SREBF1 TNNC1 NISCH MIR135A1 GLYCTK-AS1 GLYCTK WDR82 GNL3 SNORD69 PBRM1 NT5DC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR82 on UCSC Golden Path with GeneCards custom track

Promoters for WDR82 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001364209 20 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for WDR82 Gene

Chromosome:
3
Start:
52,254,421 bp from pter
End:
52,288,020 bp from pter
Size:
33,600 bases
Orientation:
Minus strand

Genomic View for WDR82 Gene

Genes around WDR82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR82 Gene

Proteins for WDR82 Gene

  • Protein details for WDR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN9-WDR82_HUMAN
    Recommended name:
    WD repeat-containing protein 82
    Protein Accession:
    Q6UXN9
    Secondary Accessions:
    • A8K5R5
    • Q8TEB2

    Protein attributes for WDR82 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on Ser-5 of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.
    SequenceCaution:
    • Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for WDR82 Gene

Post-translational modifications for WDR82 Gene

  • Ubiquitination at Lys 2, Lys 63, Lys 84, Lys 98, Lys 129, Lys 188, and Lys 280
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR82 Gene

No data available for DME Specific Peptides for WDR82 Gene

Domains & Families for WDR82 Gene

Gene Families for WDR82 Gene

Suggested Antigen Peptide Sequences for WDR82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN9

UniProtKB/Swiss-Prot:

WDR82_HUMAN :
  • Belongs to the WD repeat SWD2 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat SWD2 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR82: view

Function for WDR82 Gene

Molecular function for WDR82 Gene

UniProtKB/Swiss-Prot Function:
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Ontology (GO) - Molecular Function for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,IBA --
GO:0005515 protein binding IPI 17998332
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view
genes like me logo Genes that share phenotypes with WDR82: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR82 Gene

Localization for WDR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR82 Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR82 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus IEA --
GO:0016021 integral component of membrane IEA --
GO:0035097 histone methyltransferase complex IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view

Pathways & Interactions for WDR82 Gene

genes like me logo Genes that share pathways with WDR82: view

Pathways by source for WDR82 Gene

1 Cell Signaling Technology pathway for WDR82 Gene
1 KEGG pathway for WDR82 Gene

Gene Ontology (GO) - Biological Process for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051568 histone H3-K4 methylation IDA 17355966
GO:0080182 histone H3-K4 trimethylation IBA --
genes like me logo Genes that share ontologies with WDR82: view

No data available for SIGNOR curated interactions for WDR82 Gene

Transcripts for WDR82 Gene

Unigene Clusters for WDR82 Gene

WD repeat domain 82:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR82 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - - - -

Relevant External Links for WDR82 Gene

GeneLoc Exon Structure for
WDR82
ECgene alternative splicing isoforms for
WDR82

Expression for WDR82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR82 Gene

Protein differential expression in normal tissues from HIPED for WDR82 Gene

This gene is overexpressed in Lymph node (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR82 Gene



Protein tissue co-expression partners for WDR82 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR82 Gene:

WDR82

SOURCE GeneReport for Unigene cluster for WDR82 Gene:

Hs.194110
genes like me logo Genes that share expression patterns with WDR82: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR82 Gene

Orthologs for WDR82 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR82 34 35
  • 99.79 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
-- 35
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR82 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR82 34 35
  • 94.46 (n)
cow
(Bos Taurus)
Mammalia WDR82 34
  • 93.93 (n)
WDR82P1 35
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr82 34
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Wdr82 34 16 35
  • 92.01 (n)
chicken
(Gallus gallus)
Aves WDR82 34 35
  • 84.45 (n)
lizard
(Anolis carolinensis)
Reptilia WDR82 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr82 34
  • 79.45 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr82 34 35
  • 80.19 (n)
twf2a 35
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009700 34
  • 64.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wdr82 34 35
  • 62.73 (n)
worm
(Caenorhabditis elegans)
Secernentea swd-2.2 34 35
  • 50.55 (n)
swd-2.1 35
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD2 34 35 37
  • 45.9 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18063g 34
  • 45.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL099W 34
  • 44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66240 34
  • 51.52 (n)
rice
(Oryza sativa)
Liliopsida Os07g0589400 34
  • 50.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes swd2 34
  • 48.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07885 34
  • 44.88 (n)
Species where no ortholog for WDR82 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR82 Gene

ENSEMBL:
Gene Tree for WDR82 (if available)
TreeFam:
Gene Tree for WDR82 (if available)

Paralogs for WDR82 Gene

(2) SIMAP similar genes for WDR82 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR82 Gene

genes like me logo Genes that share paralogs with WDR82: view

No data available for Paralogs for WDR82 Gene

Variants for WDR82 Gene

Sequence variations from dbSNP and Humsavar for WDR82 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10561173 -- 52,263,053(+) AACCC(-/CA)GAGAT intron-variant
rs1060330 -- 52,254,929(-) CTCAC(A/G)GTCTC utr-variant-3-prime
rs111250548 -- 52,274,711(+) CAACA(C/T)GGCCA intron-variant
rs111670716 -- 52,260,198(+) GTGGC(A/G)GACAC intron-variant
rs111825834 -- 52,255,005(+) TGGCA(C/T)GATCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR82 Gene

Variant ID Type Subtype PubMed ID
nsv460537 CNV loss 19166990
nsv470572 CNV loss 18288195
nsv963320 CNV duplication 23825009
nsv954859 CNV deletion 24416366
nsv834695 CNV loss 17160897
nsv834694 CNV gain 17160897
nsv822090 CNV gain 20364138
nsv590301 CNV loss 21841781
nsv519445 CNV gain+loss 19592680
nsv508926 CNV insertion 20534489
nsv508218 CNV deletion 20534489

Variation tolerance for WDR82 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 1.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR82 Gene

Disorders for WDR82 Gene

Relevant External Links for WDR82

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR82

No disorders were found for WDR82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR82 Gene

Publications for WDR82 Gene

  1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PMID: 17355966) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2007) 2 3 4 64
  2. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee J.H. … Skalnik D.G. (J. Biol. Chem. 2010) 3 4 64
  3. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee J.H. … Skalnik D.G. (Mol. Cell. Biol. 2008) 3 4 64
  4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PMID: 18838538) Wu M. … Shilatifard A. (Mol. Cell. Biol. 2008) 3 4 64
  5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3 4 64

Products for WDR82 Gene

Sources for WDR82 Gene

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