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Aliases for WDR82 Gene

Aliases for WDR82 Gene

  • WD Repeat Domain 82 2 3 5
  • Transmembrane Protein 113 2 3
  • TMEM113 3 4
  • WDR82A 3 4
  • SWD2 3 4
  • WD Repeat-Containing Protein 82 3
  • Protein TMEM113 4
  • PRO34047 3
  • MSTP107 3
  • PRO2730 3
  • MST107 3

External Ids for WDR82 Gene

Previous HGNC Symbols for WDR82 Gene

  • TMEM113

Previous GeneCards Identifiers for WDR82 Gene

  • GC03M096139
  • GC00U921977
  • GC03M052265

Summaries for WDR82 Gene

Entrez Gene Summary for WDR82 Gene

  • TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

GeneCards Summary for WDR82 Gene

WDR82 (WD Repeat Domain 82) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).

UniProtKB/Swiss-Prot for WDR82 Gene

  • Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Additional gene information for WDR82 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR82 Gene

Genomics for WDR82 Gene

GeneHancer (GH) Regulatory Elements for WDR82 Gene

Promoters and enhancers for WDR82 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I052274 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.4 +5.2 5165 17.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 GLYCTK WDR82 LOC101929054 PPM1M TWF2 ITIH4 PBRM1 ENSG00000173366 TLR9 SEMA3G
GH03I052236 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.4 +49.2 49231 5.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 LOC101929054 TWF2 GLYCTK RAD54L2 PBRM1 RRP9 WDR82 RFT1 MIR135A1 GLYCTK-AS1
GH03I052243 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 +42.1 42134 4.9 HDGF PKNOX1 SIN3A IRF4 ZNF48 YY1 GLIS2 ZNF143 ATF7 FOS PPM1M PBRM1 LOC101929054 GLYCTK IQCF2 IQCF5 PHF7 IQCF6 IQCF1 WDR82
GH03I052044 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +236.4 236398 14 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 ZNF207 DUSP7 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 PCBP4 WDR82 SFMBT1
GH03I052408 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 -122.5 -122520 3.9 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 BAP1 PHF7 SEMA3G TNNC1 NISCH GLYCTK-AS1 MIR135A1 GLYCTK WDR82 RNU6-856P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR82 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR82 gene promoter:

Genomic Locations for WDR82 Gene

Genomic Locations for WDR82 Gene
chr3:52,254,421-52,288,020
(GRCh38/hg38)
Size:
33,600 bases
Orientation:
Minus strand
chr3:52,288,437-52,322,036
(GRCh37/hg19)

Genomic View for WDR82 Gene

Genes around WDR82 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR82 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR82 Gene

Proteins for WDR82 Gene

  • Protein details for WDR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN9-WDR82_HUMAN
    Recommended name:
    WD repeat-containing protein 82
    Protein Accession:
    Q6UXN9
    Secondary Accessions:
    • A8K5R5
    • Q8TEB2

    Protein attributes for WDR82 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on Ser-5 of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.
    SequenceCaution:
    • Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for WDR82 Gene

Post-translational modifications for WDR82 Gene

  • Ubiquitination at isoforms=2, isoforms=63, posLast=8484, isoforms=98, posLast=129129, posLast=188188, and posLast=280280

Other Protein References for WDR82 Gene

No data available for DME Specific Peptides for WDR82 Gene

Domains & Families for WDR82 Gene

Gene Families for WDR82 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN9

UniProtKB/Swiss-Prot:

WDR82_HUMAN :
  • Belongs to the WD repeat SWD2 family.
Family:
  • Belongs to the WD repeat SWD2 family.
genes like me logo Genes that share domains with WDR82: view

Function for WDR82 Gene

Molecular function for WDR82 Gene

UniProtKB/Swiss-Prot Function:
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Phenotypes From GWAS Catalog for WDR82 Gene

Gene Ontology (GO) - Molecular Function for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA,IEA --
GO:0005515 protein binding IPI 17998332
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view
genes like me logo Genes that share phenotypes with WDR82: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR82 Gene

Localization for WDR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR82 Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR82 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with WDR82: view

Pathways & Interactions for WDR82 Gene

genes like me logo Genes that share pathways with WDR82: view

Pathways by source for WDR82 Gene

1 Cell Signaling Technology pathway for WDR82 Gene
1 KEGG pathway for WDR82 Gene

Gene Ontology (GO) - Biological Process for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051568 histone H3-K4 methylation IEA,IDA 17355966
GO:0080182 histone H3-K4 trimethylation IBA --
genes like me logo Genes that share ontologies with WDR82: view

No data available for SIGNOR curated interactions for WDR82 Gene

Drugs & Compounds for WDR82 Gene

No Compound Related Data Available

Transcripts for WDR82 Gene

Unigene Clusters for WDR82 Gene

WD repeat domain 82:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR82 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - - - -

Relevant External Links for WDR82 Gene

GeneLoc Exon Structure for
WDR82
ECgene alternative splicing isoforms for
WDR82

Expression for WDR82 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR82 Gene

Protein differential expression in normal tissues from HIPED for WDR82 Gene

This gene is overexpressed in Lymph node (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR82 Gene



Protein tissue co-expression partners for WDR82 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR82 Gene:

WDR82

SOURCE GeneReport for Unigene cluster for WDR82 Gene:

Hs.194110

Evidence on tissue expression from TISSUES for WDR82 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with WDR82: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR82 Gene

Orthologs for WDR82 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR82 33 34
  • 99.79 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 84 (a)
OneToMany
-- 34
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR82 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR82 33 34
  • 94.46 (n)
cow
(Bos Taurus)
Mammalia WDR82 33
  • 93.93 (n)
WDR82P1 34
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr82 33
  • 92.76 (n)
mouse
(Mus musculus)
Mammalia Wdr82 33 16 34
  • 92.01 (n)
chicken
(Gallus gallus)
Aves WDR82 33 34
  • 84.45 (n)
lizard
(Anolis carolinensis)
Reptilia WDR82 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr82 33
  • 79.45 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr82 33 34
  • 80.19 (n)
twf2a 34
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009700 33
  • 64.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta Wdr82 33 34
  • 62.73 (n)
worm
(Caenorhabditis elegans)
Secernentea swd-2.2 33 34
  • 50.55 (n)
swd-2.1 34
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD2 33 34 36
  • 45.9 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18063g 33
  • 45.51 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL099W 33
  • 44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66240 33
  • 51.52 (n)
rice
(Oryza sativa)
Liliopsida Os07g0589400 33
  • 50.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes swd2 33
  • 48.65 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07885 33
  • 44.88 (n)
Species where no ortholog for WDR82 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR82 Gene

ENSEMBL:
Gene Tree for WDR82 (if available)
TreeFam:
Gene Tree for WDR82 (if available)

Paralogs for WDR82 Gene

(2) SIMAP similar genes for WDR82 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR82 Gene

genes like me logo Genes that share paralogs with WDR82: view

No data available for Paralogs for WDR82 Gene

Variants for WDR82 Gene

Sequence variations from dbSNP and Humsavar for WDR82 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000282813 -- 52,275,102(-) T/A intron_variant
rs1000388354 -- 52,268,659(-) T/C intron_variant
rs1000412275 -- 52,258,344(-) T/C intron_variant
rs1000512221 -- 52,263,487(-) T/C intron_variant
rs1000528596 -- 52,255,394(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR82 Gene

Variant ID Type Subtype PubMed ID
nsv460537 CNV loss 19166990
nsv470572 CNV loss 18288195
nsv508218 CNV deletion 20534489
nsv508926 CNV insertion 20534489
nsv519445 CNV gain+loss 19592680
nsv590301 CNV loss 21841781
nsv822090 CNV gain 20364138
nsv834694 CNV gain 17160897
nsv834695 CNV loss 17160897
nsv954859 CNV deletion 24416366
nsv963320 CNV duplication 23825009

Variation tolerance for WDR82 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 1.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR82 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR82 Gene

Disorders for WDR82 Gene

Additional Disease Information for WDR82

No disorders were found for WDR82 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR82 Gene

Publications for WDR82 Gene

  1. Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. (PMID: 17355966) Lee JH … Skalnik DG (The Journal of biological chemistry 2007) 2 3 4 58
  2. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee JH … Skalnik DG (The Journal of biological chemistry 2010) 3 4 58
  3. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee JH … Skalnik DG (Molecular and cellular biology 2008) 3 4 58
  4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PMID: 18838538) Wu M … Shilatifard A (Molecular and cellular biology 2008) 3 4 58
  5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa LA … Zhang H (Nature cell biology 2006) 3 4 58

Products for WDR82 Gene

Sources for WDR82 Gene

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