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Aliases for WDR82 Gene

Aliases for WDR82 Gene

  • WD Repeat Domain 82 2 3
  • TMEM113 3 4 6
  • Transmembrane Protein 113 2 3
  • WDR82A 3 4
  • SWD2 3 4
  • WD Repeat-Containing Protein 82 3
  • Protein TMEM113 4
  • PRO34047 3
  • MSTP107 3
  • PRO2730 3
  • MST107 3

External Ids for WDR82 Gene

Previous HGNC Symbols for WDR82 Gene

  • TMEM113

Previous GeneCards Identifiers for WDR82 Gene

  • GC03M096139
  • GC00U921977
  • GC03M052265

Summaries for WDR82 Gene

Entrez Gene Summary for WDR82 Gene

  • TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes (Lee and Skalnik, 2005 [PubMed 16253997]; Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Jul 2010]

GeneCards Summary for WDR82 Gene

WDR82 (WD Repeat Domain 82) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway. GO annotations related to this gene include chromatin binding and histone methyltransferase activity (H3-K4 specific).

UniProtKB/Swiss-Prot for WDR82 Gene

  • Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR82 Gene

Genomics for WDR82 Gene

Regulatory Elements for WDR82 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR82 Gene

Start:
52,254,421 bp from pter
End:
52,288,020 bp from pter
Size:
33,600 bases
Orientation:
Minus strand

Genomic View for WDR82 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR82 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR82 Gene

Proteins for WDR82 Gene

  • Protein details for WDR82 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UXN9-WDR82_HUMAN
    Recommended name:
    WD repeat-containing protein 82
    Protein Accession:
    Q6UXN9
    Secondary Accessions:
    • A8K5R5
    • Q8TEB2

    Protein attributes for WDR82 Gene

    Size:
    313 amino acids
    Molecular mass:
    35079 Da
    Quaternary structure:
    • Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats phosphorylated on Ser-5 of each heptad. SETD1A enhances its interaction with POLR2A. Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS.
    SequenceCaution:
    • Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for WDR82 Gene

Proteomics data for WDR82 Gene at MOPED

Post-translational modifications for WDR82 Gene

  • Ubiquitination at Lys63, Lys84, Lys98, Lys129, Lys188, and Lys280
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR82 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR82 Gene

Domains for WDR82 Gene

Gene Families for WDR82 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR82 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UXN9

UniProtKB/Swiss-Prot:

WDR82_HUMAN :
  • Q6UXN9
Family:
  • Belongs to the WD repeat SWD2 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR82: view

Function for WDR82 Gene

Molecular function for WDR82 Gene

UniProtKB/Swiss-Prot Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 Lys-4 methylation via recruitment of the SETD1A or SETD1B to the Ser-5 phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Gene Ontology (GO) - Molecular Function for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 17998332
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view
genes like me logo Genes that share phenotypes with WDR82: view

Animal Model Products

CRISPR Products

miRNA for WDR82 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR82

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR82 Gene

Localization for WDR82 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR82 Gene

Nucleus. Note=Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR82 Gene COMPARTMENTS Subcellular localization image for WDR82 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 20516061
GO:0005634 nucleus --
GO:0035097 histone methyltransferase complex IDA 17355966
GO:0048188 Set1C/COMPASS complex IDA 17998332
GO:0072357 PTW/PP1 phosphatase complex IDA 20516061
genes like me logo Genes that share ontologies with WDR82: view

Pathways for WDR82 Gene

SuperPathways for WDR82 Gene

Superpath Contained pathways
1 mRNA surveillance pathway
genes like me logo Genes that share pathways with WDR82: view

Pathways by source for WDR82 Gene

1 KEGG pathway for WDR82 Gene

Gene Ontology (GO) - Biological Process for WDR82 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051568 histone H3-K4 methylation IDA 17355966
genes like me logo Genes that share ontologies with WDR82: view

Transcripts for WDR82 Gene

Unigene Clusters for WDR82 Gene

WD repeat domain 82:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR82

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR82 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2: - - - -

Relevant External Links for WDR82 Gene

GeneLoc Exon Structure for
WDR82
ECgene alternative splicing isoforms for
WDR82

Expression for WDR82 Gene

mRNA expression in normal human tissues for WDR82 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR82 Gene

SOURCE GeneReport for Unigene cluster for WDR82 Gene Hs.194110

genes like me logo Genes that share expressions with WDR82: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR82 Gene

Orthologs for WDR82 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR82 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR82 35
  • 99.79 (n)
  • 100 (a)
WDR82 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR82 35
  • 93.93 (n)
  • 100 (a)
WDR82P1 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR82 35
  • 94.46 (n)
  • 100 (a)
WDR82 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr82 35
  • 92.01 (n)
  • 100 (a)
Wdr82 16
Wdr82 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia WDR82 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr82 35
  • 92.76 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves WDR82 35
  • 84.45 (n)
  • 97.76 (a)
WDR82 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR82 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr82 35
  • 79.45 (n)
  • 95.85 (a)
zebrafish
(Danio rerio)
Actinopterygii twf2a 36
  • 48 (a)
OneToMany
wdr82 35
  • 80.19 (n)
  • 93.61 (a)
wdr82 36
  • 94 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009700 35
  • 64.95 (n)
  • 70.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta Wdr82 35
  • 62.73 (n)
  • 69.01 (a)
Wdr82 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swd-2.1 36
  • 32 (a)
OneToMany
swd-2.2 35
  • 50.55 (n)
  • 44.08 (a)
swd-2.2 36
  • 41 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL099W 35
  • 44 (n)
  • 36.03 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD2 35
  • 45.9 (n)
  • 36.36 (a)
SWD2 36
  • 33 (a)
OneToOne
SWD2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18063g 35
  • 45.51 (n)
  • 36.54 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66240 35
  • 51.52 (n)
  • 41.23 (a)
rice
(Oryza sativa)
Liliopsida Os07g0589400 35
  • 50.16 (n)
  • 38.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07885 35
  • 44.88 (n)
  • 38.94 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes swd2 35
  • 48.65 (n)
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for WDR82:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR82 Gene

ENSEMBL:
Gene Tree for WDR82 (if available)
TreeFam:
Gene Tree for WDR82 (if available)

Paralogs for WDR82 Gene

Selected SIMAP similar genes for WDR82 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR82 Gene

genes like me logo Genes that share paralogs with WDR82: view

No data available for Paralogs for WDR82 Gene

Variants for WDR82 Gene

Sequence variations from dbSNP and Humsavar for WDR82 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1767 -- 52,256,458(+) AAAAA(C/G)GCTAA utr-variant-3-prime
rs1769 -- 52,256,534(+) TCTGA(A/G)GACTA utr-variant-3-prime
rs699465 -- 52,276,426(+) actcc(A/G)tcccc intron-variant
rs1060330 -- 52,254,929(-) CTCAC(A/G)GTCTC utr-variant-3-prime
rs3210487 -- 52,259,843(-) CAGTA(C/T)GATCG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for WDR82 Gene

Variant ID Type Subtype PubMed ID
nsv519445 CNV Gain+Loss 19592680
nsv470572 CNV Loss 18288195
nsv460537 CNV Loss 19166990
nsv508218 CNV Loss 20534489
nsv508926 CNV Insertion 20534489
nsv834694 CNV Gain 17160897
nsv834695 CNV Loss 17160897
dgv5136n71 CNV Gain 21882294
nsv876789 CNV Loss 21882294
nsv822090 CNV Gain 20364138

Relevant External Links for WDR82 Gene

HapMap Linkage Disequilibrium report
WDR82

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR82 Gene

Disorders for WDR82 Gene

No disorders were found for WDR82 Gene.

No data available for UniProtKB/Swiss-Prot for WDR82 Gene

Publications for WDR82 Gene

  1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PMID: 17355966) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2007) 2 3 4
  2. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PMID: 17998332) Lee J.H. … Skalnik D.G. (Mol. Cell. Biol. 2008) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PMID: 16253997) Lee J.-H. … Skalnik D.G. (J. Biol. Chem. 2005) 3 4

Products for WDR82 Gene

Sources for WDR82 Gene

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