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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR82 Gene

protein-coding   GIFtS: 52
GCID: GC03M052265

WD Repeat Domain 82

(Previous name: transmembrane protein 113)
(Previous symbol: TMEM113)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 821 2     PRO27302
TMEM1131 2 3 5     PRO340472
Transmembrane Protein 1131 2     SWD22
WDR82A2 3     WD Repeat-Containing Protein 822
MST1072     Swd23
MSTP1072     Protein TMEM1133

External Ids:    HGNC: 288261   Entrez Gene: 803352   Ensembl: ENSG000001640917   OMIM: 6110595   UniProtKB: Q6UXN93   

Export aliases for WDR82 gene to outside databases

Previous GC identifers: GC03M096139 GC00U921977


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR82 Gene:
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4
methyltransferase complexes (Lee and Skalnik, 2005 (PubMed 16253997); Lee et al., 2007 (PubMed
17355966)).(supplied by OMIM, Jul 2010)

GeneCards Summary for WDR82 Gene: 
WDR82 (WD repeat domain 82) is a protein-coding gene. Diseases associated with WDR82 include north american indian childhood cirrhosis. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and chromatin binding.

UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9
Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional
start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B
to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of
PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression
during the transition from mitosis into interphase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR82 gene promoter:
         CREB   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR82 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR82

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.2

WDR82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR82 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052265:  view genomic region     (about GC identifiers)

Start:
52,288,437 bp from pter      End:
52,322,036 bp from pter
Size:
33,600 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9 (See protein sequence)
Recommended Name: WD repeat-containing protein 82  
Size: 313 amino acids; 35079 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5,
WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of
PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including
an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B.
Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with
hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to
CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A.
Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS
Subcellular location: Nucleus. Note=Associates with chromatin
Caution: The gene encoding this protein shares one overlapping exon with TMEM113
Sequence caution: Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5R5 Q8TEB2

Explore the universe of human proteins at neXtProt for WDR82: NX_Q6UXN9

Explore proteomics data for WDR82 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UXN9

  • WDR82 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR82 Protein Expression
    REFSEQ proteins: NP_079498.2  
    ENSEMBL proteins: 
     ENSP00000296490   ENSP00000420779   ENSP00000417313  

    Human Recombinant Protein Products for WDR82: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA--
    GO:0005634nucleus ----
    GO:0035097histone methyltransferase complex IDA17355966
    GO:0048188Set1C/COMPASS complex IDA17998332
    GO:0072357PTW/PP1 phosphatase complex IDA--

    WDR82 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6UXN9

    ProtoNet protein and cluster: Q6UXN9

    UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9
    Similarity: Belongs to the WD repeat SWD2 family
    Similarity: Contains 6 WD repeats


    WDR82 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR82_HUMAN, Q6UXN9
    Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional
    start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B
    to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of
    PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression
    during the transition from mitosis into interphase

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI17998332
    GO:0042800contributes to histone methyltransferase activity (H3-K4 specific) IDA17355966
         
    WDR82 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for WDR82:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR82 
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    miRTarBase miRNAs that target WDR82:
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    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR82 (see all 108):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-1224-3p
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WDR82 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for WDR82):
        mRNA surveillance pathway


    WDR82 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR82

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/151 Interacting proteins for WDR82 (Q6UXN92, 3 ENSP000002964904) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051568histone H3-K4 methylation IDA17355966

    WDR82 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR82

    Search CenterWatch for drugs/clinical trials and news about WDR82

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR82 gene: 
    NM_025222.3  

    Unigene Cluster for WDR82:

    WD repeat domain 82
    Hs.194110  [show with all ESTs]
    Unigene Representative Sequence: AK123860
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296490(uc003ddl.2) ENST00000487402(uc003ddk.2) ENST00000469000
    ENST00000463624
    miRNA
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    8/108 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR82 (see all 108):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-1224-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR82

    Additional mRNA sequence: 

    AB019571.1 AF132207.1 AF173977.1 AK074290.1 AK098435.1 AK123860.1 AK130177.1 AK291380.1 
    AY358264.1 BC018941.1 BX648628.1 

    18 DOTS entries:

    DT.91738421  DT.114616  DT.100823236  DT.99927557  DT.86844349  DT.95204458  DT.92022663  DT.100823231 
    DT.120888493  DT.120888519  DT.120888520  DT.120888527  DT.120888540  DT.92017245  DT.99939241  DT.99979390 
    DT.100693504  DT.99973420 

    24/372 AceView cDNA sequences (see all 372):

    BU154617 AI184979 AI886293 CR612750 AI761643 AY358264 BQ672507 BE882577 
    AI629031 CB136423 NM_025222 BQ953248 AW105217 BM832509 BM680064 AW954150 
    AI394212 AI337438 AL045811 W95028 F20660 F36838 BM472646 CN484423 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WDR82    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:        -     -     -     -                                 


    ECgene alternative splicing isoforms for WDR82

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGTCTT
    WDR82 Expression
    About this image


    See WDR82 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR82

    SOURCE GeneReport for Unigene cluster: Hs.194110
        SABiosciences Custom PCR Arrays for WDR82
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR82 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr821 , 5 WD repeat domain containing 821, 5 92.01(n)1
    100(a)1
      9 (57.46 cM)5
    773051  NM_029896.11  NP_084172.11 
     1061709295 
    chicken
    (Gallus gallus)
    Aves WDR821 WD repeat domain 82 84.45(n)
    97.76(a)
      415942  NM_001006135.1  NP_001006135.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR826
    Uncharacterized protein
    95(a)
    1 ↔ 1
    2(153322573-153340683)
    zebrafish
    (Danio rerio)
    Actinopterygii wdr821 WD repeat domain containing 82 80.19(n)
    93.61(a)
      321614  NM_001166268.1  NP_001159740.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG172931 CG17293 62.73(n)
    69.01(a)
      34153  NM_135373.2  NP_609217.1 
    worm
    (Caenorhabditis elegans)
    Secernentea swd-2.21 Protein SWD-2.2 49.73(n)
    42.35(a)
      177561  NM_068879.5  NP_501280.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWD2(YKL018W)4 Subunit of the COMPASS (Set1C) complex, which methylates more   --   11(404102-405091) 853851  NP_012907.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G662401 transducin/WD40 domain-containing protein 51.52(n)
    41.23(a)
      836756  NM_126022.3  NP_569031.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05894001 hypothetical protein 50.38(n)
    37.79(a)
      4343770  NM_001066685.1  NP_001060150.2 


    ENSEMBL Gene Tree for WDR82 (if available)
    TreeFam Gene Tree for WDR82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR82 gene
    2 SIMAP similar genes for WDR82 using alignment to 3 protein entries:     WDR82_HUMAN (see all proteins):
    GNB3    KATNB1

    WDR82 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WDR82
    PGOHUM00000244097 PGOHUM00000237686


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/383 SNPs in WDR82 are shown (see all 383)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428409381,2
    --52287991(+) GCCAGA/GCTGGG 1 -- ds50010--------
    rs1809497571,2
    --52288042(+) GAAACC/GAGGGT 1 -- ds50010--------
    rs1502309411,2
    C--52288048(+) AGGGTC/TTAGCA 1 -- ds50010--------
    rs1385759931,2
    --52288186(+) TGCCCC/TGTCAG 1 -- ds50010--------
    rs1492890931,2
    --52288187(+) GCCCCA/GTCAGT 1 -- ds50010--------
    rs1502897671,2
    --52288216(+) ATTAC-/AAGCCT 1 -- ds50010--------
    rs1445608871,2
    --52288529(+) AATAAC/TGACTA 1 -- ut310--------
    rs1148886121,2
    C,F--52288571(+) TGTCTA/GGGGGG 1 -- ut311Minor allele frequency- G:0.07WA 118
    rs1397198071,2
    --52288625(+) CAAACC/TTGATT 1 -- ut310--------
    rs1437419581,2
    C--52288662(+) AATAAA/GCAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR82 (52288437 - 52322036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for WDR82:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv834694CNV Gain17160897
    dgv5136n71CNV Gain21882294
    nsv822090CNV Gain20364138
    nsv519445CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611059    OMIM disorders: --

    2 diseases for WDR82:    About MalaCards
    north american indian childhood cirrhosis    


    WDR82 for disorders           About GeneDecksing


    Export disorders for WDR82 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR82 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with WDR82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2, 3 Lee J.-H.... Skalnik D.G. (2007)
    2. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H....Skalnik D.G. (2010)
    3. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
    4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
    5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
    6. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2 Lee J.-H. and Skalnik D.G. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80335 HGNC: 28826 AceView: PRO2730 Ensembl:ENSG00000164091 euGenes: HUgn80335
    ECgene: WDR82 Kegg: 80335 H-InvDB: WDR82

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR82 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR82 gene:
    Search GeneIP for patents involving WDR82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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