WDR82 Gene
protein-coding GIFtS: 52
GCID: GC03M052265
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WD repeat domain 82(Previous name: transmembrane protein 113 )
(Previous symbol: TMEM113)
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Aliases
for WDR82 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 821 2 | | PRO340471 2 | | TMEM1131 2 3 5 | | SWD21 2 | | WDR82A1 2 3 | | Transmembrane Protein 1131 2 | | MST1071 2 | | WD Repeat-Containing Protein 822 | | MSTP1071 2 | | Swd23 | | PRO27301 2 | | Protein TMEM1133 |
Export aliases for WDR82 gene to outside databasesPrevious GC identifers: GC03M096139 GC00U921977 |
Summaries
for WDR82 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR82:
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferasecomplexes (Lee and Skalnik, 2005 (PubMed 16253997); Lee et al., 2007 (PubMed 17355966)).(supplied by OMIM, Jul 2010)
UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional startsites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during thetransition from mitosis into interphase
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Genomic Views
for WDR82 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR82 gene promoter:
CREB deltaCREB FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR82
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR82 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.2 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.2WDR82 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052265: view genomic region
(about GC identifiers)
Start:
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52,288,437 bp from pter |
End:
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52,322,036 bp from pter |
Size:
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33,600 bases |
Orientation:
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minus strand |
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Proteins
for WDR82 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9 (See
protein sequence)Recommended Name: WD repeat-containing protein 82 Size: 313 amino acids; 35079 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82,RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed ofPPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including anRNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B. Interactswith RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts withhyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTDheptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A. Interacts withPPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS
Subcellular location: Nucleus. Note=Associates with chromatin
Caution: The gene encoding this protein shares one overlapping exon with TMEM113
Sequence caution: Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5R5 Q8TEB2Explore the universe of human proteins at neXtProt for WDR82: NX_Q6UXN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UXN9
WDR82 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079498.2
ENSEMBL proteins: ENSP00000296490 ENSP00000420779 ENSP00000417313
Human Recombinant Protein Products for WDR82:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
WDR82 for ontologies About GeneDecksing
WDR82 Antibody Products:
Assay Products for WDR82: |
Protein
Domains /
Families
for WDR82 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR82 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6UXN9ProtoNet protein and cluster: Q6UXN9 UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9Similarity: Belongs to the WD repeat SWD2 familySimilarity: Contains 6 WD repeats |
Function
for WDR82 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: WDR82_HUMAN, Q6UXN9Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional startsites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during thetransition from mitosis into interphase Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003682 | chromatin binding |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0042800 | contributes to histone methyltransferase activity (H3-K4 specific) |
IDA | 17355966 |
WDR82 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for WDR82:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR82 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR82 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for WDR82 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR82 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR82 |
|
Pathways & Interactions
for WDR82 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR82
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/147 Interacting proteins for WDR82 (Q6UXN92, 3 ENSP000002964904) via UniProtKB, MINT, STRING, and/or I2D (see all 147)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
WDR82 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR82 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR82
Search CenterWatch for drugs/clinical trials and news about WDR82
|
Transcripts
for WDR82 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR82 gene: NM_025222.3 Unigene Cluster for WDR82: WD repeat domain 82 Hs.194110 [show with all ESTs]Unigene Representative Sequence: AK1238604 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000296490(uc003ddl.2) ENST00000487402(uc003ddk.2) ENST00000469000
ENST00000463624
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR82 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR82 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR82 (NM_025222) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR82 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR82 |
Additional cDNA sequence: AB019571.1 AF132207.1 AF173977.1 AK074290.1 AK098435.1 AK123860.1 AK130177.1 AK291380.1 AY358264.1 BC018941.1 BX648628.1 19 DOTS entries: DT.91738421 DT.114616 DT.100823236 DT.99927557 DT.86844349 DT.95204458 DT.92022663 DT.99973420 DT.100823231 DT.120888493 DT.120888519 DT.120888520 DT.120888527 DT.120888540 DT.92017245 DT.99939241 DT.99979390 DT.100693504 DT.104750 24/372 AceView cDNA sequences (see all 372): BM675671 BP346304 AW268401 BF111563 BQ422955 AF173977 AI886293 AY358264 BU188714 AA350272 AI337438 BU169496 BQ953248 BM832509 AA972968 BM680064 BM873747 BE019799 BU193132 BE882577 CN484423 BQ675118 NM_025222 AI184979
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for WDR82 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR82
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Expression
for WDR82 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACAGTCTT
About this image
See WDR82 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR82
SOURCE GeneReport for Unigene cluster: Hs.194110
SABiosciences Custom PCR Arrays for WDR82
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR82
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR82 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR82 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR82 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR82 |
Orthologs
for WDR82 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR82 gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for WDR82 (if available)
TreeFam Gene Tree for WDR82 (if available) |
Paralogs
for WDR82 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR82 gene
2 SIMAP similar genes for WDR82 using alignment to 3 protein entries: WDR82_HUMAN (see all proteins):GNB3 KATNB1
WDR82 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for WDR82
PGOHUM00000244097 PGOHUM00000237686
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Genomic Variants
for WDR82 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR82 (52288437 - 52322036 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WDR82
2 CNVs: 51113 4337 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for WDR82 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR82 for disorders About GeneDecksing
OMIM gene information: 611059
OMIM disorders: --
2  diseases for WDR82: About MalaCardsnorth american indian childhood cirrhosis malaria
Export disorders for WDR82 gene to outside databases
|
Publications
for WDR82 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR82 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with WDR82) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2, 3 Lee J.-H.... Skalnik D.G. (2007)
- Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H....Skalnik D.G. (2010)
- Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (2008)
- Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (2008)
- CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
- CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2 Lee J.-H. and Skalnik D.G. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for WDR82 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR82 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR82 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR82 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR82 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR82 gene:
Search GeneIP for patents involving WDR82
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR82 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | WDR82 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR82 |
|  |  |  |  | | | | ThermoFisher Antibody for WDR82 |
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