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WDR82 Gene

protein-coding   GIFtS: 52
GCID: GC03M052265

WD Repeat Domain 82

(Previous name: transmembrane protein 113)
(Previous symbol: TMEM113)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 821 2     PRO27302
TMEM1131 2 3 5     PRO340472
Transmembrane Protein 1131 2     SWD22
WDR82A2 3     WD Repeat-Containing Protein 822
MST1072     Swd23
MSTP1072     Protein TMEM1133

External Ids:    HGNC: 288261   Entrez Gene: 803352   Ensembl: ENSG000001640917   OMIM: 6110595   UniProtKB: Q6UXN93   

Export aliases for WDR82 gene to outside databases

Previous GC identifers: GC03M096139 GC00U921977


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR82 Gene:
TMEM113 (WDR82) is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4
methyltransferase complexes (Lee and Skalnik, 2005 (PubMed 16253997); Lee et al., 2007 (PubMed
17355966)).(supplied by OMIM, Jul 2010)

GeneCards Summary for WDR82 Gene:
WDR82 (WD repeat domain 82) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and chromatin binding.

UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9
Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional
start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B
to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of
PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression
during the transition from mitosis into interphase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR82 gene promoter:
         CREB   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR82 promoter sequence
   Search Chromatin IP Primers for WDR82

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR82


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.2

WDR82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR82 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052265:  view genomic region     (about GC identifiers)

Start:
52,288,437 bp from pter      End:
52,322,036 bp from pter
Size:
33,600 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9 (See protein sequence)
Recommended Name: WD repeat-containing protein 82  
Size: 313 amino acids; 35079 Da
Subunit: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5,
WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Component of the PTW/PP1 phosphatase complex, composed of
PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Associated with multiple protein complexes including
an RNA polymerase II complex, MLL3/MLL4 complex and a chaperonin-containing TCP1 complex. Interacts with CUL4B.
Interacts with RBBP5 and SETD1B. Interacts with SETD1A (via RRM domain). Interacts with POLR2B. Interacts with
hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to
CTD heptad repeats phosphorylated on 'Ser-5' of each heptad. SETD1A enhances its interaction with POLR2A.
Interacts with PPP1R10/PNUTS. Interacts with PPP1CA in the presence of PPP1R10/PNUTS
Caution: The gene encoding this protein shares one overlapping exon with TMEM113
Sequence caution: Sequence=BAB85039.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8K5R5 Q8TEB2

Explore the universe of human proteins at neXtProt for WDR82: NX_Q6UXN9

Explore proteomics data for WDR82 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63, Lys84, Lys98, Lys129, Lys188, Lys280
  • Modification sites at PhosphoSitePlus

  • See WDR82 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079498.2  
    ENSEMBL proteins: 
     ENSP00000296490   ENSP00000420779   ENSP00000417313  

    WDR82 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for WDR82 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6UXN9

    ProtoNet protein and cluster: Q6UXN9

    UniProtKB/Swiss-Prot: WDR82_HUMAN, Q6UXN9
    Similarity: Belongs to the WD repeat SWD2 family
    Similarity: Contains 6 WD repeats


    Find genes that share domains with WDR82           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR82_HUMAN, Q6UXN9
    Function: Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional
    start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B
    to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of
    PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression
    during the transition from mitosis into interphase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding IPI17998332
    GO:0042800contributes to histone methyltransferase activity (H3-K4 specific) IDA17355966
         
    Find genes that share ontologies with WDR82           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for WDR82:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR82
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    miRNA
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    miRTarBase miRNAs that target WDR82:
    hsa-mir-30a-5p (MIRT005216), hsa-mir-17-5p (MIRT050892), hsa-mir-30a-3p (MIRT028388), hsa-mir-92b-3p (MIRT040688)

    Block miRNA regulation of human, mouse, rat WDR82 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR82 (see all 108):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-1224-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR82


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR82_HUMAN, Q6UXN9: Nucleus. Note=Associates with chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IDA--
    GO:0005634nucleus ----
    GO:0035097histone methyltransferase complex IDA17355966
    GO:0048188Set1C/COMPASS complex IDA17998332
    GO:0072357PTW/PP1 phosphatase complex IDA--

    Find genes that share ontologies with WDR82           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR82 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with WDR82           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for WDR82):
        mRNA surveillance pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR82
    Interactions:

        Search GeneGlobe Interaction Network for WDR82

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR82 (Q6UXN92, 3 ENSP000002964904) via UniProtKB, MINT, STRING, and/or I2D (see all 222)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051568histone H3-K4 methylation IDA17355966

    Find genes that share ontologies with WDR82           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR82



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR82 gene: 
    NM_025222.3  

    Unigene Cluster for WDR82:

    WD repeat domain 82
    Hs.194110  [show with all ESTs]
    Unigene Representative Sequence: AK123860
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296490(uc003ddl.2) ENST00000487402(uc003ddk.2) ENST00000469000
    ENST00000463624
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate WDR82 (see all 108):
    hsa-miR-411* hsa-miR-3130-5p hsa-miR-193a-3p hsa-miR-3607-3p hsa-miR-607 hsa-miR-640 hsa-miR-106a hsa-miR-1224-3p
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    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for WDR82 (see all 8)
    OriGene ORF clones in mouse, rat for WDR82
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR82 (NM_025222)
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    Primer
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    OriGene qPCR primer pairs and template standards for WDR82
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR82
      QuantiTect SYBR Green Assays in human, mouse, rat WDR82
      QuantiFast Probe-based Assays in human, mouse, rat WDR82

    Additional mRNA sequence: 

    AB019571.1 AF132207.1 AF173977.1 AK074290.1 AK098435.1 AK123860.1 AK130177.1 AK291380.1 
    AY358264.1 BC018941.1 BX648628.1 

    18 DOTS entries:

    DT.91738421  DT.114616  DT.100823236  DT.99927557  DT.86844349  DT.95204458  DT.92022663  DT.100823231 
    DT.120888493  DT.120888519  DT.120888520  DT.120888527  DT.120888540  DT.92017245  DT.99939241  DT.99979390 
    DT.100693504  DT.99973420 

    Selected AceView cDNA sequences (see all 372):

    CR604741 AW268409 AI174990 BE882577 AA350272 BU193132 BM785026 BQ422955 
    BP346304 AI337438 AI697509 AI761643 BF111563 BF477798 AI197790 NM_025222 
    BQ072881 BE044317 AU252619 BQ953248 AA377004 BQ675118 AW044098 BQ882001 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for WDR82    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                                            
    SP2:        -     -     -     -                                 


    ECgene alternative splicing isoforms for WDR82

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR82 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGTCTT
    WDR82 Expression
    About this image

    WDR82 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR82 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194110
        Custom PCR Arrays for WDR82
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR82

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR82 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr821 , 5 WD repeat domain containing 821, 5 92.01(n)1
    100(a)1
      9 (57.46 cM)5
    773051  NM_029896.11  NP_084172.11 
     1061709295 
    chicken
    (Gallus gallus)
    Aves WDR821 WD repeat domain 82 84.45(n)
    97.76(a)
      415942  NM_001006135.1  NP_001006135.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR826
    WD repeat domain 82
    95(a)
    1 ↔ 1
    2(153322573-153340683)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr821 WD repeat domain 82 79.45(n)
    95.85(a)
      448141  NM_001004854.1  NP_001004854.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr821 WD repeat domain containing 82 80.19(n)
    93.61(a)
      321614  NM_001166268.1  NP_001159740.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Wdr821 Wdr82 62.73(n)
    69.01(a)
      34153  NM_135373.3  NP_609217.1 
    worm
    (Caenorhabditis elegans)
    Secernentea swd-2.21 swd-2.2 50.55(n)
    44.08(a)
      177561  NM_068879.6  NP_501280.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWD2(YKL018W)4
    SWD21
    Subunit of the COMPASS (Set1C) complex, which methylates more4
    SWD21
    45.9(n)1
    36.36(a)1
      11(404102-405091)4
    8538511, 4  NP_012907.31  NP_012907.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G662401 AT5G66240 51.52(n)
    41.23(a)
      836756  NM_126022.3  NP_569031.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05894001 Os07g0589400 50.16(n)
    38.11(a)
      4343770  NM_001066685.1  NP_001060150.2 


    ENSEMBL Gene Tree for WDR82 (if available)
    TreeFam Gene Tree for WDR82 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR82 gene
    2 SIMAP similar genes for WDR82 using alignment to 3 protein entries:     WDR82_HUMAN (see all proteins):
    GNB3    KATNB1

    Find genes that share paralogs with WDR82           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WDR82
    PGOHUM00000244097 PGOHUM00000237686


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR82 (see all 383)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428409381,2
    --52287991(+) GCCAGA/GCTGGG 1 -- ds50010--------
    rs1809497571,2
    --52288042(+) GAAACC/GAGGGT 1 -- ds50010--------
    rs1502309411,2
    C--52288048(+) AGGGTC/TTAGCA 1 -- ds50010--------
    rs1385759931,2
    --52288186(+) TGCCCC/TGTCAG 1 -- ds50010--------
    rs1492890931,2
    --52288187(+) GCCCCA/GTCAGT 1 -- ds50010--------
    rs1502897671,2
    --52288216(+) ATTAC-/AAGCCT 1 -- ds50010--------
    rs1445608871,2
    --52288529(+) AATAAC/TGACTA 1 -- ut310--------
    rs1148886121,2
    C,F--52288571(+) TGTCTA/GGGGGG 1 -- ut311Minor allele frequency- G:0.07WA 118
    rs1397198071,2
    --52288625(+) CAAACC/TTGATT 1 -- ut310--------
    rs1437419581,2
    C--52288662(+) AATAAA/GCAGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR82 (52288437 - 52322036 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for WDR82:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv834694CNV Gain17160897
    dgv5136n71CNV Gain21882294
    nsv822090CNV Gain20364138
    nsv519445CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing WDR82
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611059    OMIM disorders: --


    Find genes that share disorders with WDR82           About GenesLikeMe


    Export disorders for WDR82 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR82 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with WDR82)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)1, 2, 3 Lee J.-H.... Skalnik D.G. (J. Biol. Chem. 2007)
    2. Identification and characterization of a novel human PP1 phosphatase complex. (PubMed id 20516061)1, 2 Lee J.H.... Skalnik D.G. (J. Biol. Chem. 2010)
    3. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (Mol. Cell. Biol. 2008)
    4. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)1, 2 Wu M....Shilatifard A. (Mol. Cell. Biol. 2008)
    5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (Nat. Cell Biol. 2006)
    6. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. (PubMed id 16253997)1, 2 Lee J.-H. and Skalnik D.G. (J. Biol. Chem. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80335 HGNC: 28826 AceView: PRO2730 Ensembl:ENSG00000164091 euGenes: HUgn80335
    ECgene: WDR82 Kegg: 80335 H-InvDB: WDR82

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR82 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WDR82 gene:
    Search GeneIP for patents involving WDR82

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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