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WDR81 Gene

protein-coding   GIFtS: 49
GCID: GC17P001619

WD Repeat Domain 81

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 811 2
CAMRQ22 5
WD Repeat-Containing Protein 812

External Ids:    HGNC: 266001   Entrez Gene: 1249972   Ensembl: ENSG000001677167   OMIM: 6142185   UniProtKB: Q562E73   

Export aliases for WDR81 gene to outside databases

Previous GC identifer: GC17P001567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR81 Gene:
This gene encodes a multi-domain transmembrane protein, which is predominantly expressed in the brain. Mutations
in this gene are associated with autosomal recessive cerebellar ataxia, mental retardation, and dysequilibrium
syndrome-2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jun 2012)

GeneCards Summary for WDR81 Gene:
WDR81 (WD repeat domain 81) is a protein-coding gene. Diseases associated with WDR81 include cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2, and dysequilibrium syndrome. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NT_187611.1  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR81 gene promoter:
         E2F-3a   E2F-4   E2F-5   Olf-1   E2F-2   CUTL1   HEN1   E2F   E2F-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR81 promoter sequence
   Search Chromatin IP Primers for WDR81

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR81


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

WDR81 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR81 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P001619:  view genomic region     (about GC identifiers)

Start:
1,619,817 bp from pter      End:
1,641,893 bp from pter
Size:
22,077 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WDR81_HUMAN, Q562E7 (See protein sequence)
Recommended Name: WD repeat-containing protein 81  
Size: 1941 amino acids; 211697 Da
Sequence caution: Sequence=BAG53978.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KW16 B3KXU1 B7Z579 E9PHG7 Q24JP6 Q8N277 Q8N3F3 Q8TEL1
Alternative splicing: 6 isoforms:  Q562E7-1   Q562E7-2   Q562E7-3   Q562E7-4   Q562E7-5   Q562E7-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR81: NX_Q562E7

Explore proteomics data for WDR81 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1235
  • Modification sites at PhosphoSitePlus

  • See WDR81 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157145.1  NP_001157281.1  NP_001157283.1  NP_689561.2  

    ENSEMBL proteins: 
     ENSP00000395226   ENSP00000460742   ENSP00000312074   ENSP00000401560   ENSP00000407845  
     ENSP00000395198   ENSP00000386609   ENSP00000458811   ENSP00000466240   ENSP00000391074  
     ENSP00000442726  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR000409 BEACH_dom
     IPR011009 Kinase-like_dom
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q562E7

    ProtoNet protein and cluster: Q562E7

    UniProtKB/Swiss-Prot: WDR81_HUMAN, Q562E7
    Similarity: Contains 1 BEACH domain
    Similarity: Contains 5 WD repeats


    WDR81 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016772transferase activity, transferring phosphorus-containing groups IEA--
         
    WDR81 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR81:
     Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR81
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR81
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR81

    miRNA
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    miRTarBase miRNAs that target WDR81:
    hsa-mir-128-3p (MIRT045880)

    Block miRNA regulation of human, mouse, rat WDR81 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR81 (see all 21):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-25 hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidWDR81 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR81

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR81


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR81
    Interactions:

        Search GeneGlobe Interaction Network for WDR81

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for WDR81 (ENSP000003866094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP4CENSP000002793874STRING: ENSP00000279387
    BLNKENSP000002243374STRING: ENSP00000224337
    PPP1CAENSP000003260314STRING: ENSP00000326031
    UBCENSP000003448184STRING: ENSP00000344818
    GGPS1ENSP000002828414STRING: ENSP00000282841
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010923negative regulation of phosphatase activity IDA19389623

    WDR81 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR81



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR81 gene (4 alternative transcripts): 
    NM_001163673.1  NM_001163809.1  NM_001163811.1  NM_152348.3  

    Unigene Cluster for WDR81:

    WD repeat domain 81
    Hs.234572  [show with all ESTs]
    Unigene Representative Sequence: NM_001163809
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455636 ENST00000468539 ENST00000309182(uc002fth.2) ENST00000492901
    ENST00000446363 ENST00000419248(uc002fti.2) ENST00000418841 ENST00000409644(uc002ftj.2)
    ENST00000464528 ENST00000575206 ENST00000474958 ENST00000479966 ENST00000495411
    ENST00000437219(uc010vqp.1 uc010vqq.1) ENST00000545662
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR81 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR81 (see all 21):
    hsa-miR-3678-3p hsa-miR-3194-5p hsa-miR-25 hsa-miR-200a hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidWDR81 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR81
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    GenScript: all cDNA clones in your preferred vector (see all 4): WDR81 (NM_152348)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR81
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WDR81
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR81
      QuantiTect SYBR Green Assays in human, mouse, rat WDR81
      QuantiFast Probe-based Assays in human, mouse, rat WDR81

    Additional mRNA sequence: 

    AK074356.1 AK091136.1 AK122972.1 AK123896.1 AK127946.1 AK298567.1 AK300986.1 AL834379.1 
    BC092513.1 BC114519.1 BC114568.1 

    10 DOTS entries:

    DT.313658  DT.97819703  DT.86843670  DT.100747888  DT.99963254  DT.40289653  DT.91751328  DT.120948577 
    DT.102826202  DT.120948628 

    Selected AceView cDNA sequences (see all 101):

    CD673112 CA440653 AL834379 CR621271 AK123896 AA826119 BP354361 BQ937348 
    F01373 Z41585 F08317 BM983030 AA299430 CF136998 BU688151 AW172812 
    AA150502 CF121816 NM_152348 F05128 BX334970 BE208640 F04233 AW384538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR81 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                          -     -     -     -     -     -     -     -     -                                                               
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for WDR81

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR81 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTGTCTGC
    WDR81 Expression
    About this image

    WDR81 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR81 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.234572

    UniProtKB/Swiss-Prot: WDR81_HUMAN, Q562E7
    Tissue specificity: Widely expressed. In the brain, highest levels in cerebellum and corpus callosum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR81

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR81 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr811 , 5 WD repeat domain 811, 5 85.11(n)1
    87.78(a)1
      11 (45.89 cM)5
    1926521  NM_138950.21  NP_620400.21 
     754409485 
    chicken
    (Gallus gallus)
    Aves WDR811 WD repeat domain 81 68.62(n)
    67.63(a)
      417560  XM_004946539.1  XP_004946596.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR816
    WD repeat domain 81
    66(a)
    1 ↔ 1
    GL343393.1(75805-82980)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr811 WD repeat domain 81 61.12(n)
    62.09(a)
      100485582  XM_002937146.2  XP_002937192.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003330621 WD repeat-containing protein 81-like 59.3(n)
    59.34(a)
      100333062  XM_005157657.1  XP_005157714.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67341 CG6734 48.05(n)
    38.54(a)
      34616  NM_135691.1  NP_609535.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F52C9.16
    Protein F52C9.1 (F52C9.1) mRNA, complete cds
    22(a)
    1 ↔ 1
    III(5326485-5333619) WBGene00018672


    ENSEMBL Gene Tree for WDR81 (if available)
    TreeFam Gene Tree for WDR81 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR81 (see all 697)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0682204
    Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2 (CAMRQ2)4--see VAR_0682202 P L mis40--------
    rs2002085221,2
    C--1525683(+) CTTTC-/TTTTTT 1 -- int10--------
    rs556959841,2
    C--1541514(+) GGGAGA/GCGGCC 3 -- us2k10--------
    rs1128742811,2
    C--1541514(+) GGGAGA/GCGGCC 3 -- us2k10--------
    rs129442851,2
    C--1541741(+) GAAGGG/AGCCTG 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1115058061,2
    F--1609205(+) GGTATG/AGGCAG 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1475754181,2
    --1609403(+) GCCCAG/TGGAGG 2 -- us2k10--------
    rs47908121,2
    C,F,A,H--1609411(+) AGGGGG/ACTGGG 2 -- us2k1 trp317Minor allele frequency- A:0.23NS EA NA WA 2338
    rs732910421,2
    C,F--1609485(+) GGCATG/AGCCCA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs116584491,2
    C,F,H--1609526(+) CTTGGA/GATTTC 2 -- us2k11Minor allele frequency- G:0.25NA 8

    HapMap Linkage Disequilibrium report for WDR81 (1619817 - 1641893 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for WDR81:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1946CNV Insertion18451855
    dgv3033n71CNV Loss21882294
    nsv907515CNV Loss21882294
    nsv516886CNV Loss19592680
    nsv907511CNV Loss21882294
    nsv907502CNV Loss21882294
    nsv470568CNV Loss18288195
    nsv512467CNV Loss21212237
    nsv9490CNV Loss18304495
    nsv833335CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): WDR81
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR81
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR81

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614218   
    OMIM disorders: 610185  
    UniProtKB/Swiss-Prot: WDR81_HUMAN, Q562E7
  • Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2 (CAMRQ2) [MIM:610185]: A congenital
    cerebellar ataxia associated with cerebellar hypoplasia, mental retardation, and inability to walk bipedally,
    resulting in quadrupedal locomotion as a functional adaptation. Additional findings include generalized brain
    atrophy and mild hypoplasia of the corpus callosum. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 11 diseases for WDR81:    About MalaCards
    cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2    dysequilibrium syndrome    cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1    cerebellar ataxia
    chediak-higashi syndrome    cerebellar hypoplasia    ataxia    mental retardation
    multiple myeloma    malaria    myeloma

    1 disease from the University of Copenhagen DISEASES database for WDR81:
    Cerebellar ataxia

    WDR81 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR81

    Export disorders for WDR81 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR81 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with WDR81)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1, 4 O'Seaghdha C.M....KAPttgen A. (Hum. Mol. Genet. 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. (PubMed id 24068962)1 O'Seaghdha C.M....Bochud M. (PLoS Genet. 2013)
    6. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. (PubMed id 23022100)1 Franceschini N....Morris A.P. (Am. J. Hum. Genet. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Neuro-ophthalmologic findings in humans with quadrupedal locomotion. (PubMed id 22686558)1 Sarac O....Kansu T. (Ophthalmic Genet. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred. (PubMed id 21885617)2 Gulsuner S.... Ozcelik T. (Genome Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124997 HGNC: 26600 AceView: FLJ33817 Ensembl:ENSG00000167716 euGenes: HUgn124997
    ECgene: WDR81 H-InvDB: WDR81

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR81 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR81 gene:
    Search GeneIP for patents involving WDR81

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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