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Aliases for WDR78 Gene

Aliases for WDR78 Gene

  • WD Repeat Domain 78 2 3
  • WD Repeat-Containing Protein 78 3
  • DIC4 3

External Ids for WDR78 Gene

Previous GeneCards Identifiers for WDR78 Gene

  • GC01M066991
  • GC01M067278
  • GC01M065386

Summaries for WDR78 Gene

GeneCards Summary for WDR78 Gene

WDR78 (WD Repeat Domain 78) is a Protein Coding gene. An important paralog of this gene is WDR34.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR78 Gene

Genomics for WDR78 Gene

Regulatory Elements for WDR78 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR78 Gene

Start:
66,812,885 bp from pter
End:
66,925,224 bp from pter
Size:
112,340 bases
Orientation:
Minus strand

Genomic View for WDR78 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR78 Gene

Proteins for WDR78 Gene

  • Protein details for WDR78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTH9-WDR78_HUMAN
    Recommended name:
    WD repeat-containing protein 78
    Protein Accession:
    Q5VTH9
    Secondary Accessions:
    • A8K9W5
    • B5MDT3
    • H7BY80
    • Q5VTI0
    • Q8N5G5
    • Q9H5R9
    • Q9UF44

    Protein attributes for WDR78 Gene

    Size:
    848 amino acids
    Molecular mass:
    94573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR78 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR78 Gene

Proteomics data for WDR78 Gene at MOPED

Post-translational modifications for WDR78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR78 Gene

Domains for WDR78 Gene

Gene Families for WDR78 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR78 Gene

Suggested Antigen Peptide Sequences for WDR78 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VTH9

UniProtKB/Swiss-Prot:

WDR78_HUMAN :
  • Q5VTH9
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR78: view

Function for WDR78 Gene

Gene Ontology (GO) - Molecular Function for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR78: view

Phenotypes for WDR78 Gene

GenomeRNAi human phenotypes for WDR78:
genes like me logo Genes that share phenotypes with WDR78: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR78

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR78 Gene

Localization for WDR78 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR78 Gene COMPARTMENTS Subcellular localization image for WDR78 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR78 Gene

Pathways for WDR78 Gene

SuperPathways for WDR78 Gene

No Data Available

Interacting Proteins for WDR78 Gene

Gene Ontology (GO) - Biological Process for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with WDR78: view

No data available for Pathways by source for WDR78 Gene

Transcripts for WDR78 Gene

Unigene Clusters for WDR78 Gene

WD repeat domain 78:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR78

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for WDR78

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR78 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for WDR78 Gene

GeneLoc Exon Structure for
WDR78
ECgene alternative splicing isoforms for
WDR78

Expression for WDR78 Gene

mRNA expression in normal human tissues for WDR78 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR78 Gene

This gene is overexpressed in Testis (7.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for WDR78 Gene

SOURCE GeneReport for Unigene cluster for WDR78 Gene Hs.49421

genes like me logo Genes that share expressions with WDR78: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for WDR78 Gene

Orthologs for WDR78 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR78 35
  • 99.21 (n)
  • 98.94 (a)
cow
(Bos Taurus)
Mammalia WDR78 35
  • 85.32 (n)
  • 80.38 (a)
WDR78 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR78 35
  • 86.11 (n)
  • 81.4 (a)
WDR78 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr78 35
  • 79.7 (n)
  • 75.44 (a)
Wdr78 16
Wdr78 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR78 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR78 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr78 35
  • 78.59 (n)
  • 75.69 (a)
chicken
(Gallus gallus)
Aves WDR78 35
  • 63.16 (n)
  • 55.62 (a)
WDR78 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR78 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15133 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr78 35
  • 61.6 (n)
  • 54.1 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr78 35
  • 56.93 (n)
  • 50.15 (a)
wdr78 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006036 35
  • 39.34 (n)
  • 30.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dic61B 35
  • 38.58 (n)
  • 31.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13511 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for WDR78:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR78 Gene

ENSEMBL:
Gene Tree for WDR78 (if available)
TreeFam:
Gene Tree for WDR78 (if available)

Paralogs for WDR78 Gene

Paralogs for WDR78 Gene

Selected SIMAP similar genes for WDR78 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with WDR78: view

Variants for WDR78 Gene

Sequence variations from dbSNP and Humsavar for WDR78 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs166562 -- 66,863,761(+) ccTCA(A/G)TGGTA intron-variant
rs187924 -- 66,860,339(+) TATTT(C/T)TTAAA intron-variant
rs269394 -- 66,865,202(+) cagat(C/T)acttg intron-variant
rs269395 -- 66,867,928(+) ACCTG(A/C)AAGCA intron-variant
rs269396 -- 66,868,189(+) TATAC(C/T)ACTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR78 Gene

Variant ID Type Subtype PubMed ID
nsv830093 CNV Gain 17160897
nsv818200 CNV Gain 17921354
dgv235n71 CNV Loss 21882294
nsv871177 CNV Loss 21882294
nsv519580 CNV Loss 19592680
esv2677491 CNV Deletion 23128226
nsv871720 CNV Loss 21882294

Relevant External Links for WDR78 Gene

HapMap Linkage Disequilibrium report
WDR78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR78 Gene

Disorders for WDR78 Gene

No disorders were found for WDR78 Gene.

No data available for UniProtKB/Swiss-Prot for WDR78 Gene

Publications for WDR78 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for WDR78 Gene

Sources for WDR78 Gene

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