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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDR78 Gene

protein-coding GIFtS: 43
GCID: GC01M067278

WD repeat domain 78

Search for WDR78
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD Repeat Domain 78¹ ²
DIC4¹ ²
FLJ23129¹
WD Repeat-Containing Protein 78²

External Ids:	HGNC: 26252¹	Entrez Gene: 79819²	Ensembl: ENSG00000152763⁷	UniProtKB: Q5VTH9³

Export aliases for WDR78 gene to outside databases

Previous GC identifers: GC01M066991 GC01M065386

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WDR78 gene promoter:
TBP AML1a FOXF2 FOXO3 STAT5A Evi-1 FOXO3b Ik-2 FOXO3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR78 promoter sequence

Search SABiosciences Chromatin IP Primers for WDR78

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR78

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.2

WDR78 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR78 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M067278: view genomic region (about GC identifiers)

Start:	67,278,568 bp from pter	End:	67,390,570 bp from pter
Size:	112,003 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR78_HUMAN, Q5VTH9 (See protein sequence)

Recommended Name: WD repeat-containing protein 78

Size: 848 amino acids; 94573 Da

Sequence caution: Sequence=AAH32406.2; Type=Erroneous initiation;

Secondary accessions: A8K9W5 B5MDT3 Q5VTI0 Q8N5G5 Q9H5R9 Q9UF44

Alternative splicing: 3 isoforms: Q5VTH9-1 Q5VTH9-2 Q5VTH9-3 (No experimental confirmation available. Ref.1 (BAB15551) sequence differs from that shown due to frameshifts in positions 513 and 765)

Explore the universe of human proteins at neXtProt for WDR78: NX_Q5VTH9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VTH9

WDR78 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_079039.4 NP_996897.2

ENSEMBL proteins:

ENSP00000360065 ENSP00000435836 ENSP00000433682 ENSP00000360062 ENSP00000433037

ENSP00000432979 ENSP00000436463 ENSP00000360061 ENSP00000432461 ENSP00000434351

ENSP00000393182

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR78 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q5VTH9

ProtoNet protein and cluster: Q5VTH9

UniProtKB/Swiss-Prot: WDR78_HUMAN, Q5VTH9

Similarity: Contains 6 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for WDR78:

Small cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WDR78

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for WDR78 (ENSP00000360065⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPT	ENSP00000356791⁴	STRING: ENSP00000356791

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDR78
Search CenterWatch for drugs/clinical trials and news about WDR78

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WDR78 gene (2 alternative transcripts):

NM_024763.4 NM_207014.2

Unigene Cluster for WDR78:

WD repeat domain 78

Hs.49421 [show with all ESTs]

Unigene Representative Sequence: AK127011

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000371026(uc009waw.3 uc001dcx.3) ENST00000491297(uc009wax.3)

ENST00000464352 ENST00000371023(uc001dcy.3) ENST00000531552 ENST00000469450

ENST00000493572 ENST00000531980 ENST00000371022 ENST00000532629 ENST00000488333

ENST00000474506 ENST00000431318

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Additional cDNA sequence:

AK026782.1 AK127011.1 AK292830.1 AL133617.1 BC032406.1 BC126379.1 BC126381.1 BX648840.1

10 DOTS entries:

DT.92418862 DT.100012035 DT.95203443 DT.100723825 DT.121437461 DT.99980565 DT.40203068 DT.75110456

DT.91804210 DT.99958324

24/71 AceView cDNA sequences (see all 71):

CA944435 BE041427 AI638110 CA396885 AI962847 AW167412 AW299570 BM968567

AI807886 AL133617 CR620846 N67990 BQ029890 AI989799 AU280358 BU608359

NM_024763 AK091603 CD242796 CD103530 BQ015296 BI769329 CA336018 NM_207014

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR78 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b
SP1:													-																-
SP2:															-		-												-		-
SP3:																													-								-
SP4:													-

ECgene alternative splicing isoforms for WDR78

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR78 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

WDR78 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Diencephalic Roof Plate

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

See WDR78 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR78

SOURCE GeneReport for Unigene cluster: Hs.49421

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WDR78 gene from 5/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WDR78¹	WD repeat domain 78	63.97(n) 57.21(a)		429114 XM_426670.3 XP_426670.3
lizard (Anolis carolinensis)	Reptilia	WDR78⁶	--	55(a)	1 ↔ 1	GL343410.1(213754-250909)
African clawed frog (Xenopus laevis)	Amphibia	Xl.15133²	Xenopus laevis transcribed sequence with weak similarity more	73.88(n)		BJ083746.1
zebrafish (Danio rerio)	Actinopterygii	wdr78¹	WD repeat domain 78	56.86(n) 49.35(a)		553797 NM_001020759.1 NP_001018595.1
fruit fly (Drosophila melanogaster)	Insecta	CG7051¹	CG7051	37.84(n) 27.7(a)		38020 NM_167796.3 NP_728477.1

ENSEMBL Gene Tree for WDR78 (if available)
TreeFam Gene Tree for WDR78 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WDR78 gene

WDR63² DNAI2² DYNC1I1² WDR34² DNAI1² DYNC1I2²

1 SIMAP similar gene for WDR78 using alignment to 11 protein entries: WDR78_HUMAN (see all proteins):

DNAI1

WDR78 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150130817^1,2		--	67278135(+)	`CTAGG-/GTGTGTG`	1	--	int¹		0	--	--	--	--
rs184151224^1,2		--	67278181(+)	`TGTGTC/GTGTGT`	1	--	int¹		0	--	--	--	--
rs144148833^1,2		--	67278323(+)	`TCCTTC/TTGAAG`	1	--	int¹		0	--	--	--	--
rs78912503^1,2	C,F,	--	67278493(+)	`TATACG/ACNNNN`	1	--	int¹		1		NA	120
rs188555621^1,2		--	67278637(+)	`AGAAAG/TACAAA`	1	--	ut3¹		0	--	--	--	--
rs191517455^1,2		--	67278732(+)	`CCTTGC/TTTTTG`	1	--	ut3¹		0	--	--	--	--
rs183670967^1,2		--	67278803(+)	`TTCCCA/GCTGTT`	1	--	ut3¹		0	--	--	--	--
rs189348568^1,2		--	67278886(+)	`CTATCA/GTCTCC`	1	--	ut3¹		0	--	--	--	--
rs138994589^1,2		--	67278925(+)	`CCCATC/TATGTC`	1	--	ut3¹		0	--	--	--	--
rs504095^1,2	C,F,H,	--	67279194(+)	`CAGATG/TAATTT`	1	--	ut3¹ ese³		13		MN NS EA NA WA	1574

HapMap Linkage Disequilibrium report for WDR78 (67278568 - 67390570 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WDR78
3 CNVs: 48353 48352 9361

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR78 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR78)

Utopia: connect your pdf to the dynamic
world of online information

A unified taxonomy for ciliary dyneins. (PubMed id 21953912)^{1, 3} Hom E.F....King S.M. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79819	HGNC: 26252	AceView: FLJ23129	Ensembl:ENSG00000152763	euGenes: HUgn79819
ECgene: WDR78	H-InvDB: WDR78

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR78	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR78 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR78 gene:
Search GeneIP for patents involving WDR78

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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WDR78 Gene

WD repeat domain 78

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WDR78 Gene

WD repeat domain 78

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