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Aliases for WDR78 Gene

Aliases for WDR78 Gene

  • WD Repeat Domain 78 2 3 5
  • WD Repeat-Containing Protein 78 3
  • DIC4 3

External Ids for WDR78 Gene

Previous GeneCards Identifiers for WDR78 Gene

  • GC01M066991
  • GC01M067278
  • GC01M065386

Summaries for WDR78 Gene

GeneCards Summary for WDR78 Gene

WDR78 (WD Repeat Domain 78) is a Protein Coding gene. An important paralog of this gene is DNAI1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR78 Gene

Genomics for WDR78 Gene

Regulatory Elements for WDR78 Gene

Enhancers for WDR78 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F066923 1.1 ENCODE 26.3 -0.4 -411 4.3 HDGF WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS WDR78 TCTEX1D1 MIER1 SLC35D1
GH01F066929 1.1 ENCODE 25.7 -7.4 -7376 6.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF416 ZNF143 WDR78 TCTEX1D1 MIER1 SLC35D1
GH01F066943 1.1 Ensembl ENCODE 25.6 -19.6 -19634 3.0 PKNOX1 RARA ZNF366 FOS EGR2 ZNF362 PPARG NR2F2 ZSCAN16 GLIS1 WDR78 MIER1 SLC35D1
GH01F067018 1 Ensembl ENCODE 25.2 -94.7 -94716 2.2 PKNOX1 MTA2 JUN ZBTB8A ZIC2 NR2F2 HIC1 ZNF316 ZFHX2 SMARCA4 WDR78 C1orf141 ENSG00000252433 MIER1 SLC35D1
GH01F066980 0.9 Ensembl ENCODE 26.5 -56.5 -56489 2.0 SOX5 SOX13 IRF2 FOXA3 HLF RAD21 ZBTB40 ZNF366 CEBPA IRF1 WDR78 MIER1 SLC35D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR78 on UCSC Golden Path with GeneCards custom track

Promoters for WDR78 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000283156 -205 3801 HDGF WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 ZNF263

Genomic Location for WDR78 Gene

66,812,885 bp from pter
66,925,095 bp from pter
112,211 bases
Minus strand

Genomic View for WDR78 Gene

Genes around WDR78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR78 Gene

Proteins for WDR78 Gene

  • Protein details for WDR78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 78
    Protein Accession:
    Secondary Accessions:
    • A8K9W5
    • B5MDT3
    • H7BY80
    • Q5VTI0
    • Q8N5G5
    • Q9H5R9
    • Q9UF44

    Protein attributes for WDR78 Gene

    848 amino acids
    Molecular mass:
    94573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR78 Gene


neXtProt entry for WDR78 Gene

Post-translational modifications for WDR78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR78 Gene

Domains & Families for WDR78 Gene

Gene Families for WDR78 Gene

Protein Domains for WDR78 Gene

Suggested Antigen Peptide Sequences for WDR78 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 WD repeats.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR78: view

Function for WDR78 Gene

genes like me logo Genes that share phenotypes with WDR78: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR78 Gene

Localization for WDR78 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR78 gene
Compartment Confidence
nucleus 3
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR78 Gene

Pathways & Interactions for WDR78 Gene

SuperPathways for WDR78 Gene

No Data Available

Interacting Proteins for WDR78 Gene

Gene Ontology (GO) - Biological Process for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with WDR78: view

No data available for Pathways by source and SIGNOR curated interactions for WDR78 Gene

Transcripts for WDR78 Gene

Unigene Clusters for WDR78 Gene

WD repeat domain 78:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR78 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for WDR78 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR78 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR78 Gene

This gene is overexpressed in Testis (x7.7).

Protein differential expression in normal tissues from HIPED for WDR78 Gene

This gene is overexpressed in Heart (55.1) and Platelet (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR78 Gene

Protein tissue co-expression partners for WDR78 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR78 Gene:


SOURCE GeneReport for Unigene cluster for WDR78 Gene:

genes like me logo Genes that share expression patterns with WDR78: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WDR78 Gene

Orthologs for WDR78 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR78 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR78 34
  • 99.21 (n)
(Canis familiaris)
Mammalia WDR78 34 35
  • 86.11 (n)
(Bos Taurus)
Mammalia WDR78 34 35
  • 85.32 (n)
(Mus musculus)
Mammalia Wdr78 34 16 35
  • 79.7 (n)
(Rattus norvegicus)
Mammalia Wdr78 34
  • 78.59 (n)
(Monodelphis domestica)
Mammalia WDR78 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WDR78 35
  • 60 (a)
(Gallus gallus)
Aves WDR78 34 35
  • 63.16 (n)
(Anolis carolinensis)
Reptilia WDR78 35
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr78 34
  • 61.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15133 34
(Danio rerio)
Actinopterygii wdr78 34 35
  • 56.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006036 34
  • 39.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dic61B 34
  • 38.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13511 34
Species where no ortholog for WDR78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR78 Gene

Gene Tree for WDR78 (if available)
Gene Tree for WDR78 (if available)

Paralogs for WDR78 Gene

Paralogs for WDR78 Gene

(1) SIMAP similar genes for WDR78 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with WDR78: view

Variants for WDR78 Gene

Sequence variations from dbSNP and Humsavar for WDR78 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10628084 -- 66,922,333(+) CAGTT(-/AC)ACCTA intron-variant
rs10639038 -- 66,893,093(+) GAAAG(-/A)AAAGA intron-variant
rs10701425 -- 66,922,332(+) ACAGT(-/GA)TACCT intron-variant
rs10749766 -- 66,911,238(+) ATATT(A/G)CAATG intron-variant
rs10789217 -- 66,829,257(+) GCAGC(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR78 Gene

Variant ID Type Subtype PubMed ID
nsv830093 CNV gain 17160897
nsv818200 CNV gain 17921354
nsv546444 CNV loss 21841781
nsv546443 CNV loss 21841781
nsv519580 CNV loss 19592680
esv3893634 CNV loss 25118596
esv3586303 CNV loss 21293372
esv3586302 CNV loss 21293372
esv2677491 CNV deletion 23128226

Variation tolerance for WDR78 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR78 Gene

Disorders for WDR78 Gene

Relevant External Links for WDR78

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR78 Gene

Publications for WDR78 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for WDR78 Gene

Sources for WDR78 Gene

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