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Aliases for WDR78 Gene

Aliases for WDR78 Gene

  • WD Repeat Domain 78 2 3 5
  • WD Repeat-Containing Protein 78 3
  • DIC4 3

External Ids for WDR78 Gene

Previous GeneCards Identifiers for WDR78 Gene

  • GC01M066991
  • GC01M067278
  • GC01M065386

Summaries for WDR78 Gene

GeneCards Summary for WDR78 Gene

WDR78 (WD Repeat Domain 78) is a Protein Coding gene. An important paralog of this gene is DNAI1.

Additional gene information for WDR78 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR78 Gene

Genomics for WDR78 Gene

Regulatory Elements for WDR78 Gene

Enhancers for WDR78 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H066923 1.4 ENCODE dbSUPER 26.2 -0.4 -411 4 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS WDR78 MIER1 TCTEX1D1 SLC35D1
GH01H066929 1.4 ENCODE dbSUPER 25.7 -7.4 -7376 6 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF416 ZNF143 ZNF207 WDR78 TCTEX1D1 MIER1 SLC35D1
GH01H066943 1 Ensembl ENCODE 25.6 -19.6 -19634 2 PKNOX1 SAP130 RARA TEAD3 FOSL1 ZNF366 ZSCAN5C FOSL2 FOS NR2F6 WDR78 MIER1 SLC35D1
GH01H066980 0.9 Ensembl ENCODE 26.5 -56.5 -56489 1 IRF2 FOXA2 FOXA3 ZBTB40 RAD21 YY1 FOXA1 ZSCAN21 PRDM6 HNF4A WDR78 MIER1 SLC35D1
GH01H066954 0.9 ENCODE 25.6 -30.1 -30100 1 HDAC1 ARNT CHAMP1 TCF12 GTF3C2 GATA2 ATF7 SMARCA5 NCOA1 ZEB2 WDR78 SERBP1 SLC35D1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR78 on UCSC Golden Path with GeneCards custom track

Promoters for WDR78 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000008146 -105 2401 HDGF ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 SP3

Genomic Location for WDR78 Gene

Chromosome:
1
Start:
66,812,885 bp from pter
End:
66,925,095 bp from pter
Size:
112,211 bases
Orientation:
Minus strand

Genomic View for WDR78 Gene

Genes around WDR78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR78 Gene

Proteins for WDR78 Gene

  • Protein details for WDR78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VTH9-WDR78_HUMAN
    Recommended name:
    WD repeat-containing protein 78
    Protein Accession:
    Q5VTH9
    Secondary Accessions:
    • A8K9W5
    • B5MDT3
    • H7BY80
    • Q5VTI0
    • Q8N5G5
    • Q9H5R9
    • Q9UF44

    Protein attributes for WDR78 Gene

    Size:
    848 amino acids
    Molecular mass:
    94573 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR78 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR78 Gene

Post-translational modifications for WDR78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR78 Gene

Domains & Families for WDR78 Gene

Gene Families for WDR78 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR78 Gene

Suggested Antigen Peptide Sequences for WDR78 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR78: view

No data available for UniProtKB/Swiss-Prot for WDR78 Gene

Function for WDR78 Gene

Gene Ontology (GO) - Molecular Function for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008574 contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA --
GO:0045503 dynein light chain binding IBA --
GO:0045504 dynein heavy chain binding IBA --
genes like me logo Genes that share ontologies with WDR78: view
genes like me logo Genes that share phenotypes with WDR78: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR78
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR78 Gene

Localization for WDR78 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR78 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005858 axonemal dynein complex IBA --
genes like me logo Genes that share ontologies with WDR78: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WDR78 Gene

Pathways & Interactions for WDR78 Gene

SuperPathways for WDR78 Gene

No Data Available

Interacting Proteins for WDR78 Gene

Gene Ontology (GO) - Biological Process for WDR78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0003341 cilium movement IBA --
genes like me logo Genes that share ontologies with WDR78: view

No data available for Pathways by source and SIGNOR curated interactions for WDR78 Gene

Drugs & Compounds for WDR78 Gene

No Compound Related Data Available

Transcripts for WDR78 Gene

Unigene Clusters for WDR78 Gene

WD repeat domain 78:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for WDR78
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR78 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2: - - - -
SP3: - -
SP4: -

Relevant External Links for WDR78 Gene

GeneLoc Exon Structure for
WDR78
ECgene alternative splicing isoforms for
WDR78

Expression for WDR78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR78 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR78 Gene

This gene is overexpressed in Testis (x7.7).

Protein differential expression in normal tissues from HIPED for WDR78 Gene

This gene is overexpressed in Heart (55.1) and Platelet (13.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR78 Gene



Protein tissue co-expression partners for WDR78 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR78 Gene:

WDR78

SOURCE GeneReport for Unigene cluster for WDR78 Gene:

Hs.49421

Evidence on tissue expression from TISSUES for WDR78 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with WDR78: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR78 Gene

Orthologs for WDR78 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR78 33
  • 99.21 (n)
dog
(Canis familiaris)
Mammalia WDR78 33 34
  • 86.11 (n)
cow
(Bos Taurus)
Mammalia WDR78 33 34
  • 85.32 (n)
mouse
(Mus musculus)
Mammalia Wdr78 33 16 34
  • 79.7 (n)
rat
(Rattus norvegicus)
Mammalia Wdr78 33
  • 78.59 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR78 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR78 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR78 33 34
  • 63.16 (n)
lizard
(Anolis carolinensis)
Reptilia WDR78 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr78 33
  • 61.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15133 33
zebrafish
(Danio rerio)
Actinopterygii wdr78 33 34
  • 56.93 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006036 33
  • 39.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dic61B 33
  • 38.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13511 33
Species where no ortholog for WDR78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR78 Gene

ENSEMBL:
Gene Tree for WDR78 (if available)
TreeFam:
Gene Tree for WDR78 (if available)

Paralogs for WDR78 Gene

Paralogs for WDR78 Gene

(1) SIMAP similar genes for WDR78 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with WDR78: view

Variants for WDR78 Gene

Sequence variations from dbSNP and Humsavar for WDR78 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000574 -- 66,884,939(+) TAATT(A/G)TATAT intron-variant
rs1000006761 -- 66,913,948(+) CACTG(C/T)ACTCC intron-variant
rs1000051306 -- 66,884,653(+) TCCAT(C/G)TTCAT intron-variant
rs1000107998 -- 66,818,922(+) AAAAG(A/G)AATAA intron-variant
rs1000113140 -- 66,920,650(+) AGCAG(C/T)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR78 Gene

Variant ID Type Subtype PubMed ID
esv2677491 CNV deletion 23128226
esv3586302 CNV loss 21293372
esv3586303 CNV loss 21293372
esv3893634 CNV loss 25118596
nsv519580 CNV loss 19592680
nsv546443 CNV loss 21841781
nsv546444 CNV loss 21841781
nsv818200 CNV gain 17921354
nsv830093 CNV gain 17160897

Variation tolerance for WDR78 Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR78 Gene

Disorders for WDR78 Gene

Relevant External Links for WDR78

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR78

No disorders were found for WDR78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR78 Gene

Publications for WDR78 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom EF … King SM (Cytoskeleton (Hoboken, N.J.) 2011) 2 3 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for WDR78 Gene

Sources for WDR78 Gene

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