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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR78 Gene

protein-coding   GIFtS: 44
GCID: GC01M067278

WD Repeat Domain 78

  Search for WDR78
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 781 2
DIC42
WD Repeat-Containing Protein 782

External Ids:    HGNC: 262521   Entrez Gene: 798192   Ensembl: ENSG000001527637   UniProtKB: Q5VTH93   

Export aliases for WDR78 gene to outside databases

Previous GC identifers: GC01M066991 GC01M065386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR78 Gene: 
WDR78 (WD repeat domain 78) is a protein-coding gene. An important paralog of this gene is DNAI2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR78 gene promoter:
         TBP   AML1a   FOXF2   FOXO3   STAT5A   Evi-1   FOXO3b   Ik-2   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR78 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR78

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR78


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.3   Ensembl cytogenetic band:  1p31.3   HGNC cytogenetic band: 1p31.2

WDR78 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR78 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M067278:  view genomic region     (about GC identifiers)

Start:
67,278,568 bp from pter      End:
67,390,570 bp from pter
Size:
112,003 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR78_HUMAN, Q5VTH9 (See protein sequence)
Recommended Name: WD repeat-containing protein 78  
Size: 848 amino acids; 94573 Da
Secondary accessions: A8K9W5 B5MDT3 H7BY80 Q5VTI0 Q8N5G5 Q9H5R9 Q9UF44
Alternative splicing: 3 isoforms:  Q5VTH9-1   Q5VTH9-2   Q5VTH9-3   (No experimental confirmation available. Ref.1 (BAB15551) sequence differs from that shown due to frameshifts in positions 513 and 765)

Explore the universe of human proteins at neXtProt for WDR78: NX_Q5VTH9

Explore proteomics data for WDR78 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VTH9

  • WDR78 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR78 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_079039.4  NP_996897.2  

    ENSEMBL proteins: 
     ENSP00000360065   ENSP00000435836   ENSP00000433682   ENSP00000360062   ENSP00000433037  
     ENSP00000432979   ENSP00000436463   ENSP00000360061   ENSP00000432461   ENSP00000434351  
     ENSP00000393182  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5VTH9

    ProtoNet protein and cluster: Q5VTH9

    UniProtKB/Swiss-Prot: WDR78_HUMAN, Q5VTH9
    Similarity: Contains 6 WD repeats


    WDR78 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR78 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR78:
     Small cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR78 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR78


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR78

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for WDR78 (ENSP000003600654) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPTENSP000003567914STRING: ENSP00000356791
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR78

    Search CenterWatch for drugs/clinical trials and news about WDR78

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR78 gene (2 alternative transcripts): 
    NM_024763.4  NM_207014.2  

    Unigene Cluster for WDR78:

    WD repeat domain 78
    Hs.49421  [show with all ESTs]
    Unigene Representative Sequence: AK127011
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371026(uc009waw.3 uc001dcx.3) ENST00000491297(uc009wax.3)
    ENST00000464352 ENST00000371023(uc001dcy.3) ENST00000531552 ENST00000469450
    ENST00000493572 ENST00000531980 ENST00000371022 ENST00000532629 ENST00000488333
    ENST00000474506 ENST00000431318
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidWDR78 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR78
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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR78 (NM_207014)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR78
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR78
    Sirion Biotech Customized lentivirus for stable overexpression of WDR78 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR78
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR78

    Additional mRNA sequence: 

    AK026782.1 AK127011.1 AK292830.1 AL133617.1 BC032406.1 BC126379.1 BC126381.1 BX648840.1 

    10 DOTS entries:

    DT.92418862  DT.100012035  DT.95203443  DT.100723825  DT.121437461  DT.99980565  DT.40203068  DT.75110456 
    DT.91804210  DT.99958324 

    24/71 AceView cDNA sequences (see all 71):

    AI807886 BM968567 CR620846 AI962847 N67990 AW167412 NM_024763 BE041427 
    BU608359 CA944435 AW299570 AU280358 AI638110 CA396885 AL133617 BQ029890 
    AI989799 BX648840 AI081062 CD103530 AW290948 AK026782 NM_207014 BF223503 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR78    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                      -                                               -                                                   
    SP2:                                            -     -                                   -     -                                             
    SP3:                                                                                      -                       -                           
    SP4:                                      -                                                                                                   


    ECgene alternative splicing isoforms for WDR78

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR78 expression in normal human tissues (normalized intensities)      WDR78 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR78 Expression
    About this image


    WDR78 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/forebrain/telencephalon   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
             retina   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             trachea   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See WDR78 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR78

    SOURCE GeneReport for Unigene cluster: Hs.49421
        SABiosciences Custom PCR Arrays for WDR78
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR78

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDR78 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr781 , 5 WD repeat domain 781, 5 80.18(n)1
    75.41(a)1
      4 (47.28 cM)5
    2425841  NM_146254.41  NP_666366.41 
     1030380655 
    chicken
    (Gallus gallus)
    Aves WDR781 WD repeat domain 78 63.97(n)
    57.21(a)
      429114  XM_426670.3  XP_426670.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR786
    WD repeat domain 78
    52(a)
    1 ↔ 1
    GL343410.1(208849-251333)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151332 Xenopus laevis transcribed sequence with weak similarity more 73.88(n)    BJ083746.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr781 WD repeat domain 78 56.86(n)
    49.35(a)
      553797  NM_001020759.1  NP_001018595.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG70511 CG7051 37.84(n)
    27.7(a)
      38020  NM_167796.3  NP_728477.1 


    ENSEMBL Gene Tree for WDR78 (if available)
    TreeFam Gene Tree for WDR78 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR78 gene
    DNAI22  DNAI12  DYNC1I12  WDR342  DYNC1I22  
    1 SIMAP similar gene for WDR78 using alignment to 10 protein entries:     WDR78_HUMAN (see all proteins):
    DNAI1

    WDR78 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2077 SNPs in WDR78 are shown (see all 2077)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0576364
    ----see VAR_0576362 C W mis40--------
    VAR_0576354
    ----see VAR_0576352 G A mis40--------
    rs1501308171,2
    C--67278135(+) CTAGG-/GTGTGTG 1 -- int10--------
    rs679077461,2
    C--67278154(+) GTGTC-/TGTGTGT 1 -- int10--------
    rs596689091,2
    C--67278155(+) TGTGT-/GT/GT 
    GTGTGTGT
    TTAAG
    1 -- int12NA 4
    rs1841512241,2
    --67278181(+) TGTGTC/GTGTGT 1 -- int10--------
    rs1441488331,2
    --67278323(+) TCCTTC/TTGAAG 1 -- int10--------
    rs789125031,2
    C,F--67278493(+) TATACG/ACAGGC 1 -- int11Minor allele frequency- A:0.04NA 120
    rs1885556211,2
    --67278637(+) AGAAAG/TACAAA 1 -- ut310--------
    rs1915174551,2
    --67278732(+) CCTTGC/TTTTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR78 (67278568 - 67390570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for WDR78:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677491CNV Deletion23128226
    nsv871720CNV Loss21882294
    nsv871177CNV Loss21882294
    dgv235n71CNV Loss21882294
    nsv519580CNV Loss19592680
    nsv818200CNV Gain17921354
    nsv830093CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for WDR78

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR78 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR78)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (2011)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79819 HGNC: 26252 AceView: FLJ23129 Ensembl:ENSG00000152763 euGenes: HUgn79819
    ECgene: WDR78 H-InvDB: WDR78

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR78 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR78 gene:
    Search GeneIP for patents involving WDR78

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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