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WDR77 Gene

protein-coding   GIFtS: 60
GCID: GC01M111983

WD Repeat Domain 77

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 771 2     WD Repeat-Containing Protein 772 3
MEP502 3 5     Nbla100712
Androgen Receptor Cofactor P442 3     Methylosome Protein 502
MEP-502 3     p442
p44/Mep502 3     WD453

External Ids:    HGNC: 296521   Entrez Gene: 790842   Ensembl: ENSG000001164557   OMIM: 6117345   UniProtKB: Q9BQA13   

Export aliases for WDR77 gene to outside databases

Previous GC identifers: GC01M111695 GC01M111784 GC01M109853


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR77 Gene:
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific
arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm
proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear
ribonucleoprotein core particles (Friesen et al., 2002 (PubMed 11756452)).(supplied by OMIM, Mar 2008)

GeneCards Summary for WDR77 Gene:
WDR77 (WD repeat domain 77) is a protein-coding gene. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot: MEP50_HUMAN, Q9BQA1
Function: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific
arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm
proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core
particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also
methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the
interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage

Gene Wiki entry for WDR77 (WD repeat-containing protein 77) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR77 gene promoter:
         Nkx3-1   Nkx3-1 v4   Pbx1a   Nkx3-1 v1   Nkx2-5   Evi-1   Nkx3-1 v2   Ik-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR77 promoter sequence
   Search Chromatin IP Primers for WDR77

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR77


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.2

WDR77 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR77 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M111983:  view genomic region     (about GC identifiers)

Start:
111,982,512 bp from pter      End:
111,991,998 bp from pter
Size:
9,487 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MEP50_HUMAN, Q9BQA1 (See protein sequence)
Recommended Name: Methylosome protein 50  
Size: 342 amino acids; 36724 Da
Subunit: Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A and WDR77. Directly
interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3
and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts
with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11.
Interacts with APEX1, AR and NKX3-1
Developmental stage: Expressed in Leydig cells during fetal testicular development, especially during the second
semester. Germ cells expression is detected as early as 10 weeks of gestation
1 PDB 3D structure from and Proteopedia for WDR77:
4GQB (3D)    
Secondary accessions: B3KMW6 Q3LID2 Q53FU2 Q6JZZ5 Q96GK4 Q9BWY3

Explore the universe of human proteins at neXtProt for WDR77: NX_Q9BQA1

Explore proteomics data for WDR77 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys121
  • Modification sites at PhosphoSitePlus

  • See WDR77 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077007.1  
    ENSEMBL proteins: 
     ENSP00000235090   ENSP00000409300   ENSP00000400321  
    Reactome Protein details: Q9BQA1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQA1

    ProtoNet protein and cluster: Q9BQA1

    UniProtKB/Swiss-Prot: MEP50_HUMAN, Q9BQA1
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR77           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MEP50_HUMAN, Q9BQA1
    Function: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific
    arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm
    proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core
    particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also
    methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the
    interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16087681
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IGI12972618
         
    Find genes that share ontologies with WDR77           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDR77:
     Decreased viability with cispl  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wdr77):
     endocrine/exocrine gland  mortality/aging  normal  reproductive system  tumorigenesis 

    Find genes that share phenotypes with WDR77           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Wdr77tm1Zwan for WDR77

       genOway: Develop your customized and physiologically relevant rodent model for WDR77

    miRNA
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    Block miRNA regulation of human, mouse, rat WDR77 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR77 (see all 9):
    hsa-miR-223 hsa-miR-3163 hsa-miR-362-3p hsa-miR-4328 hsa-miR-2115 hsa-miR-205* hsa-miR-16-1* hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidWDR77 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MEP50_HUMAN, Q9BQA1: Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal
    testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to
    cytoplasmic in various tumors
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus4
    extracellular2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IGI12972618
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IGI12972618
    GO:0005794Golgi apparatus IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with WDR77           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR77 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Metabolism of non-coding RNA0.54
    snRNP Assembly0.54
    2Gene Expression
    Gene Expression0.40
    3Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with WDR77           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for WDR77
        Chromatin Regulation / Acetylation

    1 BioSystems Pathway for WDR77
        Signaling events mediated by HDAC Class I


    1 Reactome Pathway for WDR77
        snRNP Assembly


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR77
    Interactions:

        Search GeneGlobe Interaction Network for WDR77

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR77 (Q9BQA11, 2, 3 ENSP000002350904) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT5O147441, 2, 3, ENSP000003191694EBI-1237307,EBI-351098 MINT-8339059 MINT-6488590 MINT-6488488 I2D: score=4 STRING: ENSP00000319169
    YWHABP319462, 3, ENSP000003001614MINT-50967 I2D: score=3 STRING: ENSP00000300161
    AGO3Q9H9G72, 3, ENSP000003622874MINT-6489217 I2D: score=2 STRING: ENSP00000362287
    CLNS1AP541052, 3, ENSP000002633094MINT-6489217 I2D: score=2 STRING: ENSP00000263309
    CTDP1Q9Y5B02, 3, ENSP000002995434MINT-51645 I2D: score=4 STRING: ENSP00000299543
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000387spliceosomal snRNP assembly TAS--
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0008285negative regulation of cell proliferation ----
    GO:0010467gene expression TAS--

    Find genes that share ontologies with WDR77           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR77 (MEP50)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR77 gene: 
    NM_024102.2  

    Unigene Cluster for WDR77:

    WD repeat domain 77
    Hs.204773  [show with all ESTs]
    Unigene Representative Sequence: NM_024102
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000235090(uc001ebb.3 uc010owe.2 uc021orq.1) ENST00000449340
    ENST00000497278 ENST00000459665 ENST00000411751
    miRNA
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    hsa-miR-223 hsa-miR-3163 hsa-miR-362-3p hsa-miR-4328 hsa-miR-2115 hsa-miR-205* hsa-miR-16-1* hsa-miR-3941
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      QuantiFast Probe-based Assays in human, mouse, rat WDR77

    Additional mRNA sequence: 

    AB073603.1 AB074171.1 AF052183.1 AF478464.1 AK022860.1 AK223189.1 AK296163.1 AK298179.1 
    AY225316.1 BC001679.2 BC006477.1 BC009411.1 BC011778.2 BC016946.1 

    Selected DOTS entries (see all 34):

    DT.447825  DT.99932255  DT.100805611  DT.91815605  DT.95312610  DT.91775159  DT.100039585  DT.121362468 
    DT.121362600  DT.100687192  DT.95320239  DT.100687198  DT.91775154  DT.121362617  DT.100687187  DT.100039586 
    DT.92475140  DT.95320116  DT.95320223  DT.100666492  DT.100847905  DT.100849171  DT.121362461  DT.121362493 

    Selected AceView cDNA sequences (see all 549):

    CB125179 AI244488 AI079400 BE551207 BP373209 CR616007 BQ069114 AA833829 
    AL134293 CF456363 CB216409 AA026397 CB134485 AW002747 BC011778 CA447449 
    AI685438 AI341367 AW025151 AI684900 W46571 BQ058506 BF592967 AI052688 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR77 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13
    SP1:        -           -                                                                 -                                 
    SP2:                                                                                                                        
    SP3:                                                                                                                        
    SP4:                    -                                                                                                   
    SP5:                                                                                      -                                 


    ECgene alternative splicing isoforms for WDR77

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    WDR77 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCCTGACA
    WDR77 Expression
    About this image


    WDR77 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Intermediate Mesoderm
    WDR77 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR77 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.204773

    UniProtKB/Swiss-Prot: MEP50_HUMAN, Q9BQA1
    Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In
    testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells.
    Expressed in prostate cancers, in seminomas and in Leydig cell tumors

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR77

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WDR77 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr771 , 5 WD repeat domain 771, 5 88.01(n)1
    89.77(a)1
      3 (46.46 cM)5
    704651  NM_027432.31  NP_081708.11 
     1059593695 
    chicken
    (Gallus gallus)
    Aves WDR771 WD repeat domain 77 68.63(n)
    68.73(a)
      419865  NM_001030916.1  NP_001026087.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR776
    WD repeat domain 77
    65(a)
    1 ↔ 1
    4(126336338-126352207)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.85632 Xenopus laevis transcribed sequence with weak similarity more 72.91(n)    BG729890.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056278.12   -- 77.35(n)   393506  BC056278.1 


    ENSEMBL Gene Tree for WDR77 (if available)
    TreeFam Gene Tree for WDR77 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR77 gene
    1 SIMAP similar gene for WDR77 using alignment to 3 protein entries:     MEP50_HUMAN (see all proteins):
    GNB5

    Find genes that share paralogs with WDR77           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WDR77
    PGOHUM00000246107


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR77 (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158590081,2
    F--111982188(+) AAAAAA/GAAACC 1 -- int11Minor allele frequency- G:0.03WA 118
    rs12649051,2
    C,A--111982294(-) ATGATG/AGAGAA 1 -- int15Minor allele frequency- A:0.20NA WA EA 362
    rs37540331,2
    C,F,H--111982352(-) GTGGGG/AGAGCT 1 -- int113Minor allele frequency- A:0.05EA NS NA 3308
    rs741095551,2
    C,F--111982357(+) CCCCAC/ACCCTT 1 -- int12Minor allele frequency- A:0.15WA 120
    rs1421560921,2
    --111982462(+) AAAATA/GATGCA 1 -- int10--------
    rs1380650701,2
    C--111982507(+) ATCAC-/ACAACTAC 1 -- int10--------
    rs37540321,2
    C,F,H--111982604(-) GGGAAA/TGTCTG 1 -- ut3121Minor allele frequency- T:0.14EA NS NA WA 2506
    rs1511888821,2
    --111982620(+) CATAAC/TGTGAT 1 -- ut310--------
    rs1870069821,2
    --111982688(+) CAATAA/TAATCA 1 -- ut310--------
    rs1897167491,2
    --111982757(+) TTTACA/CTTAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR77 (111982512 - 111991998 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WDR77:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819848CNV Loss19587683
    nsv463250CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR77
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR77

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611734    OMIM disorders: --


    Find genes that share disorders with WDR77           About GenesLikeMe

    Genetic Association Database (GAD): WDR77
    Human Genome Epidemiology (HuGE) Navigator: WDR77 (1 document)

    Export disorders for WDR77 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR77 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with WDR77)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel WD repeat protein component of the methylosome binds Sm proteins. (PubMed id 11756452)1, 2, 3, 9 Friesen W.J....Dreyfuss G. (J. Biol. Chem. 2002)
    2. Crystal structure of the human PRMT5:MEP50 complex. (PubMed id 23071334)1, 2 Antonysamy S....Emtage S. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    3. APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process. (PubMed id 19188445)1, 2 Vascotto C.... Tell G. (Mol. Cell. Biol. 2009)
    4. An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs. (PubMed id 18984161)1, 2 Chari A....Fischer U. (Cell 2008)
    5. The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors. (PubMed id 17437848)1, 2 Liang J.J.... Lee P. (J. Urol. 2007)
    6. Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro. (PubMed id 16712789)1, 2 Furuno K.... Yamamoto K. (Biochem. Biophys. Res. Commun. 2006)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. (PubMed id 16087681)1, 2 Azzouz T.N.... Schuemperli D. (J. Biol. Chem. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79084 HGNC: 29652 AceView: OVGP1andMEP50 Ensembl:ENSG00000116455 euGenes: HUgn79084
    ECgene: WDR77 H-InvDB: WDR77

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR77 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for WDR77 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR77 gene:
    Search GeneIP for patents involving WDR77

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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