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Aliases for WDR76 Gene

Aliases for WDR76 Gene

  • WD Repeat Domain 76 2 3
  • WD Repeat-Containing Protein 76 3
  • CDW14 3

External Ids for WDR76 Gene

Previous GeneCards Identifiers for WDR76 Gene

  • GC15P041907
  • GC15P044119
  • GC15P020941

Summaries for WDR76 Gene

GeneCards Summary for WDR76 Gene

WDR76 (WD Repeat Domain 76) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR76 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR76 Gene

Genomics for WDR76 Gene

Regulatory Elements for WDR76 Gene

Genomic Location for WDR76 Gene

Start:
43,826,914 bp from pter
End:
43,868,419 bp from pter
Size:
41,506 bases
Orientation:
Plus strand

Genomic View for WDR76 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR76 Gene

Proteins for WDR76 Gene

  • Protein details for WDR76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H967-WDR76_HUMAN
    Recommended name:
    WD repeat-containing protein 76
    Protein Accession:
    Q9H967
    Secondary Accessions:
    • A0MNP5
    • Q05CI4

    Protein attributes for WDR76 Gene

    Size:
    626 amino acids
    Molecular mass:
    69769 Da
    Quaternary structure:
    • Interacts with CUL4A and/or CUL4B.

neXtProt entry for WDR76 Gene

Proteomics data for WDR76 Gene at MOPED

Post-translational modifications for WDR76 Gene

  • Ubiquitination at Lys25, Lys73, Lys335, Lys442, and Lys531
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR76 Gene

No data available for DME Specific Peptides for WDR76 Gene

Domains for WDR76 Gene

Gene Families for WDR76 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR76 Gene

Suggested Antigen Peptide Sequences for WDR76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H967

UniProtKB/Swiss-Prot:

WDR76_HUMAN :
  • Q9H967
Family:
  • Belongs to the WD repeat DDB2/WDR76 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR76: view

Function for WDR76 Gene

Molecular function for WDR76 Gene

UniProtKB/Swiss-Prot Function: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Ontology (GO) - Molecular Function for WDR76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR76: view

Animal Model Products

CRISPR Products

miRNA for WDR76 Gene

miRTarBase miRNAs that target WDR76

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR76 Gene

Localization for WDR76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR76 Gene COMPARTMENTS Subcellular localization image for WDR76 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR76 Gene

Pathways for WDR76 Gene

SuperPathways for WDR76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR76 Gene

None

No data available for Pathways by source for WDR76 Gene

Transcripts for WDR76 Gene

Unigene Clusters for WDR76 Gene

WD repeat domain 76:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR76

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for WDR76 Gene

GeneLoc Exon Structure for
WDR76
ECgene alternative splicing isoforms for
WDR76

Expression for WDR76 Gene

mRNA expression in normal human tissues for WDR76 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR76 Gene

SOURCE GeneReport for Unigene cluster for WDR76 Gene Hs.250154

genes like me logo Genes that share expressions with WDR76: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR76 Gene

Orthologs for WDR76 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR76 35
  • 99.15 (n)
  • 98.56 (a)
WDR76 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR76 35
  • 86.23 (n)
  • 79.58 (a)
WDR76 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR76 35
  • 88.41 (n)
  • 82.29 (a)
WDR76 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr76 35
  • 79.91 (n)
  • 75.24 (a)
Wdr76 16
Wdr76 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR76 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR76 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr76 35
  • 78.01 (n)
  • 71.01 (a)
chicken
(Gallus gallus)
Aves WDR76 35
  • 57.32 (n)
  • 53.5 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16201 35
wdr76 35
  • 59.64 (n)
  • 53.48 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr76 35
  • 49.08 (n)
  • 39.13 (a)
wdr76 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR194C 35
  • 40.72 (n)
  • 26.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 23 (a)
OneToOne
-- 38
CMR1 35
  • 42.29 (n)
  • 29.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16533g 35
  • 42.16 (n)
  • 27.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRS1 35
  • 43.35 (n)
  • 29.82 (a)
rice
(Oryza sativa)
Liliopsida Os08g0285200 35
  • 41.18 (n)
  • 29.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11420 35
  • 41.62 (n)
  • 31.21 (a)
Species with no ortholog for WDR76:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR76 Gene

ENSEMBL:
Gene Tree for WDR76 (if available)
TreeFam:
Gene Tree for WDR76 (if available)

Paralogs for WDR76 Gene

No data available for Paralogs for WDR76 Gene

Variants for WDR76 Gene

Sequence variations from dbSNP and Humsavar for WDR76 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs494774 -- 43,854,907(+) gattg(C/T)gccat intron-variant
rs495880 -- 43,855,067(+) gtccc(C/T)atagt intron-variant
rs528764 -- 43,838,650(+) tgatg(C/T)gcaca intron-variant
rs541871 -- 43,868,656(+) TGAAA(C/G)GTACT downstream-variant-500B
rs557886 -- 43,827,248(-) TTATT(C/G)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR76 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850
nsv511550 CNV Loss 21212237
esv2658695 CNV Deletion 23128226
esv2749627 CNV Deletion 23290073
nsv9255 CNV Gain 18304495
esv27765 CNV Gain+Loss 19812545
nsv512394 CNV Loss 21212237
esv2664548 CNV Deletion 23128226
nsv819016 CNV Gain 19587683
nsv820434 CNV Deletion 20802225
esv270548 CNV Insertion 20981092

Relevant External Links for WDR76 Gene

HapMap Linkage Disequilibrium report
WDR76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR76 Gene

Disorders for WDR76 Gene

Relevant External Links for WDR76

Genetic Association Database (GAD)
WDR76
Human Genome Epidemiology (HuGE) Navigator
WDR76
genes like me logo Genes that share disorders with WDR76: view

No data available for UniProtKB/Swiss-Prot for WDR76 Gene

Publications for WDR76 Gene

  1. Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PMID: 12860291) Fleischmann C. … Houlston R.S. (Cancer Lett. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for WDR76 Gene

Sources for WDR76 Gene

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