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Aliases for WDR76 Gene

Aliases for WDR76 Gene

  • WD Repeat Domain 76 2 3 5
  • CDW14 3

External Ids for WDR76 Gene

Previous GeneCards Identifiers for WDR76 Gene

  • GC15P041907
  • GC15P044119
  • GC15P020941

Summaries for WDR76 Gene

GeneCards Summary for WDR76 Gene

WDR76 (WD Repeat Domain 76) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR76 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR76 Gene

Genomics for WDR76 Gene

Regulatory Elements for WDR76 Gene

Enhancers for WDR76 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR76 on UCSC Golden Path with GeneCards custom track

Promoters for WDR76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR76 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR76 Gene

Chromosome:
15
Start:
43,826,914 bp from pter
End:
43,868,419 bp from pter
Size:
41,506 bases
Orientation:
Plus strand

Genomic View for WDR76 Gene

Genes around WDR76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR76 Gene

Proteins for WDR76 Gene

  • Protein details for WDR76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H967-WDR76_HUMAN
    Recommended name:
    WD repeat-containing protein 76
    Protein Accession:
    Q9H967
    Secondary Accessions:
    • A0MNP5
    • Q05CI4

    Protein attributes for WDR76 Gene

    Size:
    626 amino acids
    Molecular mass:
    69769 Da
    Quaternary structure:
    • Interacts with CUL4A and/or CUL4B.

neXtProt entry for WDR76 Gene

Proteomics data for WDR76 Gene at MOPED

Post-translational modifications for WDR76 Gene

  • Ubiquitination at Lys 25, Lys 73, Lys 335, Lys 442, and Lys 531
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR76 Gene

No data available for DME Specific Peptides for WDR76 Gene

Domains & Families for WDR76 Gene

Gene Families for WDR76 Gene

Protein Domains for WDR76 Gene

Suggested Antigen Peptide Sequences for WDR76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H967

UniProtKB/Swiss-Prot:

WDR76_HUMAN :
  • Belongs to the WD repeat DDB2/WDR76 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat DDB2/WDR76 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR76: view

Function for WDR76 Gene

Molecular function for WDR76 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
genes like me logo Genes that share phenotypes with WDR76: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR76 Gene

Localization for WDR76 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR76 Gene COMPARTMENTS Subcellular localization image for WDR76 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR76 Gene

Pathways & Interactions for WDR76 Gene

SuperPathways for WDR76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR76 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR76 Gene

Drugs & Compounds for WDR76 Gene

No Compound Related Data Available

Transcripts for WDR76 Gene

Unigene Clusters for WDR76 Gene

WD repeat domain 76:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for WDR76 Gene

GeneLoc Exon Structure for
WDR76
ECgene alternative splicing isoforms for
WDR76

Expression for WDR76 Gene

mRNA expression in normal human tissues for WDR76 Gene

Protein differential expression in normal tissues from HIPED for WDR76 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR76 Gene



SOURCE GeneReport for Unigene cluster for WDR76 Gene Hs.250154

genes like me logo Genes that share expression patterns with WDR76: view

Protein tissue co-expression partners for WDR76 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR76 Gene

Orthologs for WDR76 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR76 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR76 35
  • 86.23 (n)
  • 79.58 (a)
WDR76 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR76 35
  • 88.41 (n)
  • 82.29 (a)
WDR76 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr76 35
  • 79.91 (n)
  • 75.24 (a)
Wdr76 16
Wdr76 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR76 35
  • 99.15 (n)
  • 98.56 (a)
WDR76 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr76 35
  • 78.01 (n)
  • 71.01 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR76 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR76 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR76 35
  • 57.32 (n)
  • 53.5 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16201 35
wdr76 35
  • 59.64 (n)
  • 53.48 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr76 35
  • 49.08 (n)
  • 39.13 (a)
wdr76 36
  • 35 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR194C 35
  • 40.72 (n)
  • 26.51 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16533g 35
  • 42.16 (n)
  • 27.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMR1 35
  • 42.29 (n)
  • 29.35 (a)
-- 36
  • 23 (a)
OneToOne
CMR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DRS1 35
  • 43.35 (n)
  • 29.82 (a)
rice
(Oryza sativa)
Liliopsida Os08g0285200 35
  • 41.18 (n)
  • 29.88 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11420 35
  • 41.62 (n)
  • 31.21 (a)
Species with no ortholog for WDR76:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR76 Gene

ENSEMBL:
Gene Tree for WDR76 (if available)
TreeFam:
Gene Tree for WDR76 (if available)

Paralogs for WDR76 Gene

No data available for Paralogs for WDR76 Gene

Variants for WDR76 Gene

Sequence variations from dbSNP and Humsavar for WDR76 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs678084 - 43,828,361(+) CACCA(G/T)CCCTG reference, missense
rs3742985 - 43,866,351(-) CCCGC(C/T)GGAAT reference, missense
rs5812252 -- 43,858,244(+) TTCTG(-/T)TTTTT intron-variant
rs5812253 -- 43,866,643(+) TTTTT(-/T)GAGAT utr-variant-3-prime
rs494774 -- 43,854,907(+) gattg(C/T)gccat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR76 Gene

Variant ID Type Subtype PubMed ID
dgv742e1 CNV Complex 17122850
nsv511550 CNV Loss 21212237
esv2658695 CNV Deletion 23128226
esv2749627 CNV Deletion 23290073
nsv9255 CNV Gain 18304495
esv27765 CNV Gain+Loss 19812545
nsv512394 CNV Loss 21212237
esv2664548 CNV Deletion 23128226
nsv819016 CNV Gain 19587683
nsv820434 CNV Deletion 20802225
esv270548 CNV Insertion 20981092

Variation tolerance for WDR76 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR76 Gene

Disorders for WDR76 Gene

Relevant External Links for WDR76

Genetic Association Database (GAD)
WDR76
Human Genome Epidemiology (HuGE) Navigator
WDR76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR76

No disorders were found for WDR76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR76 Gene

Publications for WDR76 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PMID: 12860291) Fleischmann C. … Houlston R.S. (Cancer Lett. 2003) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for WDR76 Gene

Sources for WDR76 Gene

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