WDR76 Gene
protein-coding GIFtS: 45
GCID: GC15P044119
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|
WD repeat domain 76
| |
Aliases
for WDR76 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 761 2 | | FLJ129731 | | CDW142 | | WD Repeat-Containing Protein 762 |
Export aliases for WDR76 gene to outside databasesPrevious GC identifers: GC15P041907 GC15P020941 |
Summaries
for WDR76 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR76 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR76 gene promoter:
c-Fos NF-1/L NF-1 AP-1 Meis-1b FOXJ2 (long isoform) SEF-1 (1) FOXJ2 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR76
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR76 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.3 Ensembl cytogenetic band: 15q15.3 HGNC cytogenetic band: 15q15.3WDR76 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P044119: view genomic region
(about GC identifiers)
Start:
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44,119,112 bp from pter |
End:
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44,160,617 bp from pter |
Size:
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41,506 bases |
Orientation:
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plus strand |
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Proteins
for WDR76 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR76_HUMAN, Q9H967 (See
protein sequence)Recommended Name: WD repeat-containing protein 76 Size: 626 amino acids; 69769 Da
Subunit: Interacts with CUL4A and/or CUL4B
Secondary accessions: A0MNP5 Q05CI4Explore the universe of human proteins at neXtProt for WDR76: NX_Q9H967
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H967
WDR76 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001161413.1 NP_079184.2
ENSEMBL proteins: ENSP00000263795 ENSP00000370645 ENSP00000404665
Human Recombinant Protein Products:
WDR76 Antibody Products:
Assay Products for WDR76: |
Protein
Domains /
Families
for WDR76 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR76 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H967ProtoNet protein and cluster: Q9H967 UniProtKB/Swiss-Prot: WDR76_HUMAN, Q9H967Similarity: Belongs to the WD repeat DDB2/WDR76 familySimilarity: Contains 7 WD repeats |
Function
for WDR76 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDR76 (NM_024908) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR76 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR76 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR76 |
|
Pathways & Interactions
for WDR76 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR76
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/47 Interacting proteins for WDR76 (Q9H9673 ENSP000002637954) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
|
Drugs & Compounds
for WDR76 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR76
Search CenterWatch for drugs/clinical trials and news about WDR76
|
Transcripts
for WDR76 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR76 gene (2 alternative transcripts): NM_001167941.1 NM_024908.3 Unigene Cluster for WDR76: WD repeat domain 76 Hs.250154 [show with all ESTs]Unigene Representative Sequence: NM_0249084 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263795(uc021skg.1 uc001zti.2) ENST00000381246 ENST00000452115
ENST00000478130
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR76 (NM_024908) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR76 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR76 |
Additional cDNA sequence: AK023035.1 AK124169.1 AK290933.1 BC025247.1 BC051855.1 EF011624.1 8 DOTS entries: DT.434232 DT.91719777 DT.100778606 DT.106037 DT.417290 DT.121031798 DT.95375502 DT.85105449 24/87 AceView cDNA sequences (see all 87): AW946624 AW946608 AW139018 AW946610 BP339459 BC025247 CR595259 AA743653 BX956348 BC051855 BX355259 CA942737 AI341260 BX280140 BE019652 AW946612 AW407986 BP365913 BQ220867 AA625130 BU509283 NM_024908 BG258227 BU629128
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | · | 14c |
|---|
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| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR76
|
Expression
for WDR76 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGGCCATC
About this image
See WDR76 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR76
SOURCE GeneReport for Unigene cluster: Hs.250154
SABiosciences Custom PCR Arrays for WDR76
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR76
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR76 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR76 |
Orthologs
for WDR76 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR76 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for WDR76 (if available)
TreeFam Gene Tree for WDR76 (if available) |
Paralogs
for WDR76 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR76 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR76 (44119112 - 44160617 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for WDR76
4 CNVs: 30710 58721 66784 3960 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR76 |
|
Disorders
/ Diseases
for WDR76 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR76 for disorders About GeneDecksing
3  diseases for WDR76: About MalaCardsb-cell lymphomas colorectal cancer immunodeficiency
Human Genome Epidemiology (HuGE) Navigator: WDR76 (3 documents)
Export disorders for WDR76 gene to outside databases
|
Publications
for WDR76 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR76 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with WDR76) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PubMed id 12860291)1, 3 Fleischmann C....Houlston R.S. (2003)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for WDR76 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR76 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR76 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR76 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR76 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR76 gene:
Search GeneIP for patents involving WDR76
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR76 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR76 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR76 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR76 | | | OriGene Protein Over-expression Lysate for WDR76 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR76 | | OriGene 3'-UTR Clone for WDR76 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR76 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR76 | | OriGene Custom Protein Services for WDR76 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR76 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR76 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR76 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR76 |
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 |  |  |  | |
| | | | Search Tocris compounds for WDR76 |
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 | | | WDR76 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR76 |
|  |  |  | | | | ThermoFisher Antibodies for WDR76 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR76 |
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