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WDR76 Gene

protein-coding   GIFtS: 50
GCID: GC15P044119

WD Repeat Domain 76

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 761 2
CDW142
WD Repeat-Containing Protein 762

External Ids:    HGNC: 257731   Entrez Gene: 799682   Ensembl: ENSG000000924707   UniProtKB: Q9H9673   

Export aliases for WDR76 gene to outside databases

Previous GC identifers: GC15P041907 GC15P020941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR76 Gene:
WDR76 (WD repeat domain 76) is a protein-coding gene.

UniProtKB/Swiss-Prot: WDR76_HUMAN, Q9H967
Function: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR76 gene promoter:
         c-Fos   NF-1/L   NF-1   AP-1   Meis-1b   FOXJ2 (long isoform)   SEF-1 (1)   FOXJ2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR76 promoter sequence
   Search Chromatin IP Primers for WDR76

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR76


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

WDR76 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR76 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044119:  view genomic region     (about GC identifiers)

Start:
44,119,112 bp from pter      End:
44,160,617 bp from pter
Size:
41,506 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR76_HUMAN, Q9H967 (See protein sequence)
Recommended Name: WD repeat-containing protein 76  
Size: 626 amino acids; 69769 Da
Subunit: Interacts with CUL4A and/or CUL4B
Secondary accessions: A0MNP5 Q05CI4

Explore the universe of human proteins at neXtProt for WDR76: NX_Q9H967

Explore proteomics data for WDR76 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys25, Lys73, Lys335, Lys442, Lys531
  • Modification sites at PhosphoSitePlus

  • See WDR76 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161413.1  NP_079184.2  

    ENSEMBL proteins: 
     ENSP00000263795   ENSP00000370645   ENSP00000404665  

    WDR76 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WDR76

     
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    antibodies-online proteins for WDR76 (3 products) 

     
    antibodies-online peptides for WDR76

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    Cloud-Clone Corp. ELISAs for WDR76
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    antibodies-online kits for WDR76 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H967

    ProtoNet protein and cluster: Q9H967

    UniProtKB/Swiss-Prot: WDR76_HUMAN, Q9H967
    Similarity: Belongs to the WD repeat DDB2/WDR76 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR76           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR76_HUMAN, Q9H967
    Function: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC
    (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR76           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDR76

    miRNA
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    miRTarBase miRNAs that target WDR76:
    hsa-mir-192-5p (MIRT026456)

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    Selected qRT-PCR Assays for microRNAs that regulate WDR76 (see all 13):
    hsa-miR-3163 hsa-miR-7-2* hsa-miR-26b* hsa-miR-944 hsa-miR-545 hsa-miR-340 hsa-miR-1279 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidWDR76 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR76

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR76
    Interactions:

        Search GeneGlobe Interaction Network for WDR76

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR76 (Q9H9673 ENSP000002637954) via UniProtKB, MINT, STRING, and/or I2D (see all 151)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4FP628053, ENSP000003669744I2D: score=4 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=4 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR76



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR76 gene (2 alternative transcripts): 
    NM_001167941.1  NM_024908.3  

    Unigene Cluster for WDR76:

    WD repeat domain 76
    Hs.250154  [show with all ESTs]
    Unigene Representative Sequence: NM_024908
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263795(uc021skg.1 uc001zti.2) ENST00000381246 ENST00000452115
    ENST00000478130
    miRNA
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    Block miRNA regulation of human, mouse, rat WDR76 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR76 (see all 13):
    hsa-miR-3163 hsa-miR-7-2* hsa-miR-26b* hsa-miR-944 hsa-miR-545 hsa-miR-340 hsa-miR-1279 hsa-miR-4287
    SwitchGear 3'UTR luciferase reporter plasmidWDR76 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WDR76
    Predesigned siRNA for gene silencing in human, mouse, rat WDR76
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): WDR76 (NM_024908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR76
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR76
    Primer
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    OriGene qPCR primer pairs and template standards for WDR76
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR76
      QuantiTect SYBR Green Assays in human, mouse, rat WDR76
      QuantiFast Probe-based Assays in human, mouse, rat WDR76

    Additional mRNA sequence: 

    AK023035.1 AK124169.1 AK290933.1 BC025247.1 BC051855.1 EF011624.1 

    8 DOTS entries:

    DT.434232  DT.91719777  DT.100778606  DT.106037  DT.417290  DT.121031798  DT.95375502  DT.85105449 

    Selected AceView cDNA sequences (see all 87):

    AW407986 AW946608 CA942737 AW946610 AW946612 AA743653 BC025247 AI341260 
    AW946624 BP339459 AW139018 BX956348 BE019652 BX280140 BX355259 BC051855 
    CR595259 AK023035 BU159369 BQ220867 BG258227 BP353769 BP383274 BP351906 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
    SP1:                    -                                                                                                                     
    SP2:                                                                                                  -     -                                 
    SP3:                    -     -                                                                                                               
    SP4:                                                                                                                                          
    SP5:                                                                                                  -     -                                 


    ECgene alternative splicing isoforms for WDR76

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR76 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGCCATC
    WDR76 Expression
    About this image

    WDR76 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR76 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.250154
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR76

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR76 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr761 , 5 WD repeat domain 761, 5 79.91(n)1
    75.24(a)1
      2 (60.41 cM)5
    2416271  NM_030234.21  NP_084510.21 
     1215067235 
    chicken
    (Gallus gallus)
    Aves WDR761 WD repeat domain 76 57.32(n)
    53.5(a)
      426208  XM_423870.4  XP_423870.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    58(a)
    51(a)
    many → 1
    many → 1
    GL343795.1(201263-216356)
    GL343467.1(35435-50923)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ072826.12   -- 72.31(n)    BJ072826.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr761 WD repeat domain 76 49.08(n)
    39.13(a)
      570063  NM_001198567.1  NP_001185496.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YDL156W)4
    CMR11
    Putative protein of unknown function; protein sequence more4
    CMR11
    42.29(n)1
    29.35(a)1
      4(174918-176486)4
    8513991, 4  NP_010125.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DRS11 DRS1 43.35(n)
    29.82(a)
      844410  NM_106719.2  NP_178186.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g02852001 Os08g0285200 41.18(n)
    29.88(a)
      4345171  NM_001067984.1  NP_001061449.1 


    ENSEMBL Gene Tree for WDR76 (if available)
    TreeFam Gene Tree for WDR76 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR76 (see all 852)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931553431,2
    --44119006(+) CCTCAA/GGTGAT 2 -- us2k10--------
    rs1128989381,2
    C,F--44119022(+) GCCTCG/AGCCTC 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1823860061,2
    --44119108(+) CCCAAC/GTTCCT 2 -- us2k10--------
    rs1119155071,2
    C--44119163(+) GCCTCG/CGACCC 2 -- ut511Minor allele frequency- C:0.50WA 2
    rs1870683531,2
    --44119168(+) GGACCC/TGCCCC 2 -- ut510--------
    rs2003596781,2
    --44119186(+) CTCCCA/GCCGCA 2 -- ut510--------
    rs1997792271,2
    C--44119210(+) GGCGCC/G/TGGCCG 4 -- ut510--------
    rs1911607571,2
    C--44119235(+) GATGTA/CCAGGT 3 Y S mis1 ut510--------
    rs1118479231,2
    F--44119252(+) CGGCGG/ACTGAG 3 /T /A mis1 ut511Minor allele frequency- A:0.50CSA 4
    rs38329841,2
    C,F--44119314(-) CACCTT/-GGAAG 2 -- int17Minor allele frequency- -:0.25MN EA NA CSA 1262

    HapMap Linkage Disequilibrium report for WDR76 (44119112 - 44160617 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WDR76 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664548CNV Deletion23128226
    esv2658695CNV Deletion23128226
    nsv820434CNV Deletion20802225
    esv2749627CNV Deletion23290073
    esv270548CNV Insertion20981092
    nsv512394CNV Loss21212237
    nsv511550CNV Loss21212237
    nsv9255CNV Gain18304495
    nsv819016CNV Gain19587683
    esv27765CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WDR76           About GenesLikeMe

    Genetic Association Database (GAD): WDR76
    Human Genome Epidemiology (HuGE) Navigator: WDR76 (3 documents)

    Export disorders for WDR76 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR76 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with WDR76)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1, 2 Higa L.A.... Zhang H. (Nat. Cell Biol. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PubMed id 12860291)1, 3 Fleischmann C....Houlston R.S. (Cancer Lett. 2003)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Discovery and fine mapping of serum protein loci through transethnic meta-analysis. (PubMed id 23022100)1 Franceschini N....Morris A.P. (Am. J. Hum. Genet. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79968 HGNC: 25773 AceView: FLJ12973 Ensembl:ENSG00000092470 euGenes: HUgn79968
    ECgene: WDR76 H-InvDB: WDR76

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR76 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR76 gene:
    Search GeneIP for patents involving WDR76

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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