Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR76 Gene

Aliases for WDR76 Gene

  • WD Repeat Domain 76 2 3 5
  • WD Repeat-Containing Protein 76 3
  • CDW14 3

External Ids for WDR76 Gene

Previous GeneCards Identifiers for WDR76 Gene

  • GC15P041907
  • GC15P044119
  • GC15P020941

Summaries for WDR76 Gene

GeneCards Summary for WDR76 Gene

WDR76 (WD Repeat Domain 76) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR76 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR76 Gene

Genomics for WDR76 Gene

Regulatory Elements for WDR76 Gene

Enhancers for WDR76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G044681 1.5 Ensembl ENCODE dbSUPER 11.5 +856.5 856462 3.1 HDGF ATF1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B TCF12 ZNF207 NCOA1 CTDSPL2 ENSG00000259563 WDR76 GC15M044698 ENSG00000206957 SPG11
GH15G044028 0.7 ENCODE 20.1 +202.8 202771 2.5 CTCF NFIB JUN ZNF195 ZNF350 NFE2 MAFK NFE2L2 ZNF132 HLF CTDSPL2 WDR76 TP53BP1 RPS3AP47 ZSCAN29 ENSG00000259563 UBR1 ADAL GAPDHP55 ACTBP7
GH15G043823 1.2 ENCODE 11.6 -0.9 -886 5.7 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 GLIS1 ENSG00000249839 CTDSPL2 TUBGCP4 MFAP1 ADAL RPS3AP47 ELL3 ENSG00000259563 EIF3J-AS1 HNRNPMP1
GH15G043774 1.1 ENCODE 11.5 -50.4 -50440 3.6 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ADAL STRC MFAP1 WDR76 SERF2 CATSPER2P1
GH15G044286 1.1 ENCODE 10.9 +461.9 461880 3.7 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 KLF13 CTDSPL2 ENSG00000259563 TUBGCP4 ENSG00000249839 ELL3 MFAP1 WDR76 LCMT2 ENSG00000259659 ADAL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR76 on UCSC Golden Path with GeneCards custom track

Promoters for WDR76 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075883 486 1601 HDGF ARNT SIN3A CBX5 ZNF143 SP3 SP5 ZNF592 SMARCA4 GLIS1

Genomic Location for WDR76 Gene

Chromosome:
15
Start:
43,826,914 bp from pter
End:
43,868,419 bp from pter
Size:
41,506 bases
Orientation:
Plus strand

Genomic View for WDR76 Gene

Genes around WDR76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR76 Gene

Proteins for WDR76 Gene

  • Protein details for WDR76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H967-WDR76_HUMAN
    Recommended name:
    WD repeat-containing protein 76
    Protein Accession:
    Q9H967
    Secondary Accessions:
    • A0MNP5
    • Q05CI4

    Protein attributes for WDR76 Gene

    Size:
    626 amino acids
    Molecular mass:
    69769 Da
    Quaternary structure:
    • Interacts with CUL4A and/or CUL4B.

neXtProt entry for WDR76 Gene

Post-translational modifications for WDR76 Gene

  • Ubiquitination at Lys25, posLast=7373, Lys335, Lys442, and Lys531
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR76 Gene

No data available for DME Specific Peptides for WDR76 Gene

Domains & Families for WDR76 Gene

Gene Families for WDR76 Gene

Protein Domains for WDR76 Gene

Suggested Antigen Peptide Sequences for WDR76 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H967

UniProtKB/Swiss-Prot:

WDR76_HUMAN :
  • Belongs to the WD repeat DDB2/WDR76 family.
Family:
  • Belongs to the WD repeat DDB2/WDR76 family.
genes like me logo Genes that share domains with WDR76: view

Function for WDR76 Gene

Molecular function for WDR76 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
genes like me logo Genes that share phenotypes with WDR76: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR76 Gene

Localization for WDR76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR76 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR76 Gene

Pathways & Interactions for WDR76 Gene

SuperPathways for WDR76 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IEA --
genes like me logo Genes that share ontologies with WDR76: view

No data available for Pathways by source and SIGNOR curated interactions for WDR76 Gene

Drugs & Compounds for WDR76 Gene

No Compound Related Data Available

Transcripts for WDR76 Gene

Unigene Clusters for WDR76 Gene

WD repeat domain 76:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR76 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
SP1: -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for WDR76 Gene

GeneLoc Exon Structure for
WDR76
ECgene alternative splicing isoforms for
WDR76

Expression for WDR76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR76 Gene

Protein differential expression in normal tissues from HIPED for WDR76 Gene

This gene is overexpressed in Fetal ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR76 Gene



Protein tissue co-expression partners for WDR76 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR76 Gene:

WDR76

SOURCE GeneReport for Unigene cluster for WDR76 Gene:

Hs.250154

Evidence on tissue expression from TISSUES for WDR76 Gene

  • Kidney(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with WDR76: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR76 Gene

Orthologs for WDR76 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR76 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia WDR76 34 35
  • 88.41 (n)
cow
(Bos Taurus)
Mammalia WDR76 34 35
  • 86.23 (n)
mouse
(Mus musculus)
Mammalia Wdr76 34 16 35
  • 79.91 (n)
rat
(Rattus norvegicus)
Mammalia Wdr76 34
  • 78.01 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR76 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR76 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR76 34
  • 57.32 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr76 34
  • 59.64 (n)
Str.16201 34
zebrafish
(Danio rerio)
Actinopterygii wdr76 34 35
  • 49.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMR1 34 37
  • 42.29 (n)
-- 35
  • 23 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16533g 34
  • 42.16 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR194C 34
  • 40.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRS1 34
  • 43.35 (n)
rice
(Oryza sativa)
Liliopsida Os08g0285200 34
  • 41.18 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11420 34
  • 41.62 (n)
Species where no ortholog for WDR76 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR76 Gene

ENSEMBL:
Gene Tree for WDR76 (if available)
TreeFam:
Gene Tree for WDR76 (if available)

Paralogs for WDR76 Gene

No data available for Paralogs for WDR76 Gene

Variants for WDR76 Gene

Sequence variations from dbSNP and Humsavar for WDR76 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000072302 -- 43,843,262(+) GTGAG(A/C)TGTCT intron-variant
rs1000077066 -- 43,866,543(+) TACTT(A/T)TAGTA nc-transcript-variant, utr-variant-3-prime
rs1000088675 -- 43,836,718(+) TGTGA(C/G)TTAGA intron-variant
rs1000109411 -- 43,852,307(+) GCCTC(C/T)TGAGT intron-variant
rs1000230889 -- 43,849,440(+) AAAAG(G/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR76 Gene

Variant ID Type Subtype PubMed ID
dgv4503n54 CNV loss 21841781
dgv4504n54 CNV loss 21841781
dgv4505n54 CNV loss 21841781
dgv4506n54 CNV loss 21841781
dgv4507n54 CNV loss 21841781
dgv4508n54 CNV loss 21841781
dgv4509n54 CNV loss 21841781
esv2658695 CNV deletion 23128226
esv2664548 CNV deletion 23128226
esv2749627 CNV deletion 23290073
esv2760028 CNV gain+loss 17122850
esv27765 CNV gain+loss 19812545
esv3405692 CNV insertion 20981092
esv3552375 CNV deletion 23714750
esv3636299 CNV loss 21293372
esv3636300 CNV loss 21293372
nsv1036318 CNV gain 25217958
nsv1050263 CNV loss 25217958
nsv1134440 CNV deletion 24896259
nsv511550 CNV loss 21212237
nsv512394 CNV loss 21212237
nsv569277 CNV loss 21841781
nsv569296 CNV loss 21841781
nsv819016 CNV gain 19587683
nsv820434 CNV deletion 20802225
nsv9255 CNV gain 18304495

Variation tolerance for WDR76 Gene

Residual Variation Intolerance Score: 51.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR76 Gene

Disorders for WDR76 Gene

Relevant External Links for WDR76

Genetic Association Database (GAD)
WDR76
Human Genome Epidemiology (HuGE) Navigator
WDR76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR76

No disorders were found for WDR76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR76 Gene

Publications for WDR76 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mutations in the candidate tumour suppressor gene FLJ12973 on chromosome 15q15 are rare in colorectal cancer. (PMID: 12860291) Fleischmann C. … Houlston R.S. (Cancer Lett. 2003) 2 3 64

Products for WDR76 Gene

Sources for WDR76 Gene

Content
Loading form....