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Aliases for WDR75 Gene

Aliases for WDR75 Gene

  • WD Repeat Domain 75 2 3 5
  • UTP17 2 3 4
  • U3 Small Nucleolar RNA-Associated Protein 17 Homolog 3 4
  • UTP17, Small Subunit (SSU) Processome Component, Homolog 3
  • Small Subunit (SSU) Processome Component 2
  • Homolog (Yeast) 2
  • NET16 3

External Ids for WDR75 Gene

Previous GeneCards Identifiers for WDR75 Gene

  • GC02P190132
  • GC02P190014
  • GC02P190306
  • GC02P182165

Summaries for WDR75 Gene

GeneCards Summary for WDR75 Gene

WDR75 (WD Repeat Domain 75) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR75 Gene

Genomics for WDR75 Gene

Regulatory Elements for WDR75 Gene

Enhancers for WDR75 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR75 on UCSC Golden Path with GeneCards custom track

Promoters for WDR75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR75 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR75 Gene

189,441,433 bp from pter
189,475,565 bp from pter
34,133 bases
Plus strand

Genomic View for WDR75 Gene

Genes around WDR75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR75 Gene

Proteins for WDR75 Gene

  • Protein details for WDR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 75
    Protein Accession:
    Secondary Accessions:
    • Q96J10
    • Q9H8U8
    • Q9H9U5
    • Q9H9V8
    • Q9UIX2

    Protein attributes for WDR75 Gene

    830 amino acids
    Molecular mass:
    94499 Da
    Quaternary structure:
    • Forms a complex with UTP4, NOL11, UTP15 and WDR43.
    • Sequence=BAB14503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR75 Gene

Proteomics data for WDR75 Gene at MOPED

Post-translational modifications for WDR75 Gene

  • Ubiquitination at Lys 123, Lys 226, Lys 281, Lys 332, Lys 354, Lys 682, and Lys 701
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR75 Gene

No data available for DME Specific Peptides for WDR75 Gene

Domains & Families for WDR75 Gene

Gene Families for WDR75 Gene

Protein Domains for WDR75 Gene

Suggested Antigen Peptide Sequences for WDR75 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 WD repeats.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR75: view

Function for WDR75 Gene

Gene Ontology (GO) - Molecular Function for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR75: view
genes like me logo Genes that share phenotypes with WDR75: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR75 Gene

Localization for WDR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR75 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for WDR75 Gene COMPARTMENTS Subcellular localization image for WDR75 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
genes like me logo Genes that share ontologies with WDR75: view

Pathways & Interactions for WDR75 Gene

genes like me logo Genes that share pathways with WDR75: view

Pathways by source for WDR75 Gene

Gene Ontology (GO) - Biological Process for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with WDR75: view

No data available for SIGNOR curated interactions for WDR75 Gene

Drugs & Compounds for WDR75 Gene

No Compound Related Data Available

Transcripts for WDR75 Gene

Unigene Clusters for WDR75 Gene

WD repeat domain 75:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP8: - -

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP9: -

Relevant External Links for WDR75 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR75 Gene

mRNA expression in normal human tissues for WDR75 Gene

Protein differential expression in normal tissues from HIPED for WDR75 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (9.7), Placenta (9.4), Blymphocyte (8.1), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR75 Gene

SOURCE GeneReport for Unigene cluster for WDR75 Gene Hs.399984

genes like me logo Genes that share expression patterns with WDR75: view

Protein tissue co-expression partners for WDR75 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR75 Gene

Orthologs for WDR75 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR75 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR75 35
  • 90.4 (n)
  • 91.81 (a)
WDR75 36
  • 91 (a)
(Canis familiaris)
Mammalia WDR75 35
  • 90.27 (n)
  • 90.83 (a)
WDR75 36
  • 91 (a)
(Mus musculus)
Mammalia Wdr75 35
  • 85.13 (n)
  • 85.01 (a)
Wdr75 16
Wdr75 36
  • 85 (a)
(Pan troglodytes)
Mammalia WDR75 35
  • 99.44 (n)
  • 99.52 (a)
WDR75 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr75 35
  • 84.94 (n)
  • 84.15 (a)
(Monodelphis domestica)
Mammalia WDR75 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
-- 36
  • 56 (a)
(Gallus gallus)
Aves WDR75 35
  • 66.42 (n)
  • 61.77 (a)
WDR75 36
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
-- 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr75 35
  • 64.72 (n)
  • 59.59 (a)
(Danio rerio)
Actinopterygii siby113d7.2 35
wdr75 35
  • 58.98 (n)
  • 54.25 (a)
wdr75 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007948 35
  • 43.83 (n)
  • 32.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12050 35
  • 43.22 (n)
  • 31.18 (a)
CG12050 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAN1 38
(Oryza sativa)
Liliopsida Os12g0609800 35
  • 42.23 (n)
  • 29.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
CSA.2356 36
  • 30 (a)
Species with no ortholog for WDR75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR75 Gene

Gene Tree for WDR75 (if available)
Gene Tree for WDR75 (if available)

Paralogs for WDR75 Gene Pseudogenes for WDR75 Gene

genes like me logo Genes that share paralogs with WDR75: view

No data available for Paralogs for WDR75 Gene

Variants for WDR75 Gene

Sequence variations from dbSNP and Humsavar for WDR75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs963738 -- 189,464,127(-) CCTCA(A/G)TGGAA intron-variant
rs966603 -- 189,457,821(-) CATCA(G/T)TACAA intron-variant
rs1992295 -- 189,449,115(-) ATACT(A/G)AGAAA intron-variant
rs6747222 -- 189,475,727(+) CCCCT(A/T)AGCTG downstream-variant-500B
rs5837143 -- 189,455,240(+) AAAAA(-/A/AAAAAAAA)GAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR75 Gene

Variant ID Type Subtype PubMed ID
nsv875613 CNV Loss 21882294
nsv875615 CNV Gain 21882294
nsv3079 CNV Insertion 18451855
nsv483013 CNV Gain 15286789

Variation tolerance for WDR75 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.00% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR75 Gene

Disorders for WDR75 Gene

Relevant External Links for WDR75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR75 Gene

Publications for WDR75 Gene

  1. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PMID: 17699751) Prieto J.L. … McStay B. (Genes Dev. 2007) 2 3 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3

Products for WDR75 Gene

Sources for WDR75 Gene