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Aliases for WDR75 Gene

Aliases for WDR75 Gene

  • WD Repeat Domain 75 2 3 5
  • U3 Small Nucleolar RNA-Associated Protein 17 Homolog 3 4
  • UTP17 3 4
  • UTP17, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • UTP17, Small Subunit (SSU) Processome Component, Homolog 3
  • WD Repeat-Containing Protein 75 3
  • NET16 3

External Ids for WDR75 Gene

Previous GeneCards Identifiers for WDR75 Gene

  • GC02P190132
  • GC02P190014
  • GC02P190306
  • GC02P182165

Summaries for WDR75 Gene

GeneCards Summary for WDR75 Gene

WDR75 (WD Repeat Domain 75) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Ribosome biogenesis in eukaryotes. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR75 Gene

Genomics for WDR75 Gene

Regulatory Elements for WDR75 Gene

Enhancers for WDR75 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F190179 1.1 ENCODE 26.5 +741.2 741221 6.0 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ORMDL1 NEMP2 WDR75 LOC105373794 GC02M190201
GH02F189149 0.7 ENCODE 27.4 -289.4 -289392 5.0 PKNOX1 CEBPB DPF2 ZNF217 ZNF791 JUND ZNF707 GATA3 ZNF366 ZNF585B WDR75 COL5A2 OSGEPL1-AS1 OSGEPL1 MIR3129 GC02M189179 GC02M189180
GH02F189406 1.5 FANTOM5 Ensembl ENCODE 10.1 -33.0 -32971 4.3 HDAC1 TBL1XR1 ARNT CHAMP1 GATA2 FOS BCLAF1 SMAD5 ZBTB2 ZBTB11 WDR75 COL5A2 LOC100420666 LOC101927252 KRT18P19
GH02F189013 0.8 Ensembl ENCODE 18.6 -426.7 -426748 2.0 FOSL1 ZNF202 POLR2A SIN3A ZBTB33 WDR75 ORMDL1 LOC105373791 ENSG00000228073
GH02F189090 1.4 FANTOM5 Ensembl ENCODE 9.6 -346.5 -346465 8.3 CTCF JUN RAD21 RFX5 ZNF316 ZNF143 SMC3 RCOR1 FOS NFE2 COL5A2 WDR75 COL3A1 ENSG00000228073 LOC105373791
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR75 on UCSC Golden Path with GeneCards custom track

Promoters for WDR75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for WDR75 Gene

189,441,433 bp from pter
189,475,565 bp from pter
34,133 bases
Plus strand

Genomic View for WDR75 Gene

Genes around WDR75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR75 Gene

Proteins for WDR75 Gene

  • Protein details for WDR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 75
    Protein Accession:
    Secondary Accessions:
    • Q96J10
    • Q9H8U8
    • Q9H9U5
    • Q9H9V8
    • Q9UIX2

    Protein attributes for WDR75 Gene

    830 amino acids
    Molecular mass:
    94499 Da
    Quaternary structure:
    • Forms a complex with UTP4, NOL11, UTP15 and WDR43.
    • Sequence=BAB14503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR75 Gene

Post-translational modifications for WDR75 Gene

  • Ubiquitination at Lys 123, Lys 226, Lys 281, Lys 332, Lys 354, Lys 682, and Lys 701
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR75 Gene

No data available for DME Specific Peptides for WDR75 Gene

Domains & Families for WDR75 Gene

Gene Families for WDR75 Gene

Suggested Antigen Peptide Sequences for WDR75 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 WD repeats.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR75: view

Function for WDR75 Gene

Gene Ontology (GO) - Molecular Function for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR75: view
genes like me logo Genes that share phenotypes with WDR75: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR75 Gene

Localization for WDR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR75 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR75 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with WDR75: view

Pathways & Interactions for WDR75 Gene

genes like me logo Genes that share pathways with WDR75: view

Gene Ontology (GO) - Biological Process for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006364 rRNA processing TAS --
GO:0016573 histone acetylation IBA --
GO:1903146 regulation of mitophagy IMP 24912190
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24912190
genes like me logo Genes that share ontologies with WDR75: view

No data available for SIGNOR curated interactions for WDR75 Gene

Transcripts for WDR75 Gene

Unigene Clusters for WDR75 Gene

WD repeat domain 75:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP8: - -

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP9: -

Relevant External Links for WDR75 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR75 Gene

Protein differential expression in normal tissues from HIPED for WDR75 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.2), Testis (9.7), Placenta (9.4), Blymphocyte (8.1), and CD8 Tcells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR75 Gene

Protein tissue co-expression partners for WDR75 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR75 Gene:


SOURCE GeneReport for Unigene cluster for WDR75 Gene:

genes like me logo Genes that share expression patterns with WDR75: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR75 Gene

Orthologs for WDR75 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR75 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR75 34 35
  • 99.44 (n)
(Bos Taurus)
Mammalia WDR75 34 35
  • 90.4 (n)
(Canis familiaris)
Mammalia WDR75 34 35
  • 90.27 (n)
(Mus musculus)
Mammalia Wdr75 34 16 35
  • 85.13 (n)
(Rattus norvegicus)
Mammalia Wdr75 34
  • 84.94 (n)
(Monodelphis domestica)
Mammalia WDR75 35
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
-- 35
  • 56 (a)
(Gallus gallus)
Aves WDR75 34 35
  • 66.42 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
-- 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr75 34
  • 64.72 (n)
(Danio rerio)
Actinopterygii wdr75 34 35
  • 58.98 (n)
siby113d7.2 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007948 34
  • 43.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12050 34 35
  • 43.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAN1 37
(Oryza sativa)
Liliopsida Os12g0609800 34
  • 42.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
CSA.2356 35
  • 30 (a)
Species where no ortholog for WDR75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR75 Gene

Gene Tree for WDR75 (if available)
Gene Tree for WDR75 (if available)

Paralogs for WDR75 Gene Pseudogenes for WDR75 Gene

genes like me logo Genes that share paralogs with WDR75: view

No data available for Paralogs for WDR75 Gene

Variants for WDR75 Gene

Sequence variations from dbSNP and Humsavar for WDR75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10165458 -- 189,446,957(+) tttct(A/G)cgtga intron-variant
rs10166420 -- 189,471,979(+) AGAAG(A/T)CCAAT intron-variant
rs10178969 -- 189,450,997(+) TCGTT(A/C)TGTGA intron-variant
rs10181606 -- 189,464,474(+) CTCAC(C/T)GTGGC intron-variant
rs10184474 -- 189,440,722(+) ATGTT(C/G)AGATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR75 Gene

Variant ID Type Subtype PubMed ID
nsv3079 CNV insertion 18451855
nsv584062 CNV gain 21841781

Variation tolerance for WDR75 Gene

Residual Variation Intolerance Score: 70.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 41.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR75 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR75 Gene

Disorders for WDR75 Gene

Relevant External Links for WDR75

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR75 Gene

Publications for WDR75 Gene

  1. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PMID: 17699751) Prieto J.L. … McStay B. (Genes Dev. 2007) 2 3 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WDR75 Gene

Sources for WDR75 Gene

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