WDR75 Gene
protein-coding GIFtS: 50
GCID: GC02P190306
|
|
WD repeat domain 75
| |
Aliases
for WDR75 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 751 2 | | NET161 2 | | UTP171 2 | | FLJ125191 | | UTP17, Small Subunit (SSU) Processome Component, Homolog2 | | WD Repeat-Containing Protein 752 |
Export aliases for WDR75 gene to outside databasesPrevious GC identifers: GC02P190132 GC02P190014 GC02P182165 |
Summaries
for WDR75 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR75 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR75 gene promoter:
POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) MIF-1 POU3F2 C/EBPalpha GATA-6 POU2F1 POU2F1a FOXO4 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR75
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR75 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.2 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.2WDR75 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P190306: view genomic region
(about GC identifiers)
Start:
|
190,306,159 bp from pter |
End:
|
190,340,291 bp from pter |
Size:
|
34,133 bases |
Orientation:
|
plus strand |
|
Proteins
for WDR75 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR75_HUMAN, Q8IWA0 (See
protein sequence)Recommended Name: WD repeat-containing protein 75 Size: 830 amino acids; 94499 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAB14503.1; Type=Erroneous initiation;
Secondary accessions: Q96J10 Q9H8U8 Q9H9U5 Q9H9V8 Q9UIX2Explore the universe of human proteins at neXtProt for WDR75: NX_Q8IWA0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWA0
WDR75 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115544.1
ENSEMBL proteins: ENSP00000314193 ENSP00000414226 ENSP00000400728
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WDR75 for ontologies About GeneDecksing
WDR75 Antibody Products:
Assay Products for WDR75: |
Protein
Domains /
Families
for WDR75 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR75 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWA0ProtoNet protein and cluster: Q8IWA0 UniProtKB/Swiss-Prot: WDR75_HUMAN, Q8IWA0Similarity: Contains 9 WD repeats |
Function
for WDR75 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR75 (NM_032168) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR75 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR75 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR75 |
2 GenomeRNAi human phenotypes for WDR75:
|
Pathways & Interactions
for WDR75 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for WDR75):
WDR75 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR75
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for WDR75 (Q8IWA03 ENSP000003141934) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR75 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR75
Search CenterWatch for drugs/clinical trials and news about WDR75
|
Transcripts
for WDR75 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR75 gene: NM_032168.1 Unigene Cluster for WDR75: WD repeat domain 75 Hs.399984 [show with all ESTs]Unigene Representative Sequence: NM_0321686 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000314761(uc002uql.1) ENST00000436347(uc002uqm.1) ENST00000472286
ENST00000475596 ENST00000427960(uc002uqn.1) ENST00000498365
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR75 (NM_032168) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR75 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR75 |
Additional cDNA sequence: AK022581.1 AK022607.1 AK023276.1 AK091546.1 AK290445.1 AL122097.1 BC006816.1 BC018689.1 BC040567.1 14 DOTS entries: DT.91829838 DT.446724 DT.92472025 DT.95237157 DT.92472079 DT.120981584 DT.95303408 DT.40120929 DT.102821711 DT.100814212 DT.40110408 DT.91638668 DT.99956227 DT.40279953 24/227 AceView cDNA sequences (see all 227): BM479656 BQ433159 AI422759 AI635810 BC040567 AA399095 AU124827 D56876 CA447880 AA599745 AI636894 BE672397 AK023276 AA233467 H24573 AA405606 BF507734 BM466357 AI122582 AW674274 AI538740 AA166739 AA404314 AI623192
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16b | ^ | 17 | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR75
|
Expression
for WDR75 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR75 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTAAATT
About this image
See WDR75 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR75
SOURCE GeneReport for Unigene cluster: Hs.399984
SABiosciences Custom PCR Arrays for WDR75
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR75
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR75 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR75 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR75 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR75 |
Orthologs
for WDR75 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR75 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for WDR75 (if available)
TreeFam Gene Tree for WDR75 (if available) |
Paralogs
for WDR75 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR75 gene
WDR75 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WDR75
PGOHUM00000248147
|
Genomic Variants
for WDR75 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR75 (190306159 - 190340291 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR75
1 CNV: 0029 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR75 |
|
Disorders
/ Diseases
for WDR75 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR75 for disorders About GeneDecksing
2  diseases for WDR75: About MalaCardsloeys-dietz syndrome ehlers-danlos syndrome
1 disease from the University of Copenhagen DISEASES database for WDR75:Loeys-Dietz syndrome Export disorders for WDR75 gene to outside databases
|
Publications
for WDR75 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR75 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with WDR75) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PubMed id 17699751)1, 3 Prieto J.L. and McStay B. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for WDR75 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR75 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR75 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR75 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR75 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR75 gene:
Search GeneIP for patents involving WDR75
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR75 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR75 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR75 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR75 | | | OriGene Protein Over-expression Lysate for WDR75 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR75 | | OriGene 3'-UTR Clone for WDR75 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR75 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR75 | | OriGene Custom Protein Services for WDR75 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR75 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR75 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR75 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR75 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR75 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR75 |
| |
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| | | | Search Tocris compounds for WDR75 |
| |  |  |  |  | | | | |
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 |
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 | | | WDR75 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR75 |
|  |  |  | | | | ThermoFisher Antibodies for WDR75 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR75 |
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