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Aliases for WDR75 Gene

Aliases for WDR75 Gene

  • WD Repeat Domain 75 2 3
  • UTP17 2 3 4
  • UTP17, Small Subunit (SSU) Processome Component, Homolog 3
  • Small Subunit (SSU) Processome Component 2
  • WD Repeat-Containing Protein 75 3
  • Homolog (Yeast) 2
  • NET16 3

External Ids for WDR75 Gene

Summaries for WDR75 Gene

GeneCards Summary for WDR75 Gene

WDR75 (WD Repeat Domain 75) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR75 Gene

Genomics for WDR75 Gene

Genomic Location for WDR75 Gene

Start:
189,441,433 bp from pter
End:
189,475,565 bp from pter
Size:
34,133 bases
Orientation:
Plus strand

Genomic View for WDR75 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR75 Gene

Proteins for WDR75 Gene

  • Protein details for WDR75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWA0-WDR75_HUMAN
    Recommended name:
    WD repeat-containing protein 75
    Protein Accession:
    Q8IWA0
    Secondary Accessions:
    • Q96J10
    • Q9H8U8
    • Q9H9U5
    • Q9H9V8
    • Q9UIX2

    Protein attributes for WDR75 Gene

    Size:
    830 amino acids
    Molecular mass:
    94499 Da
    Quaternary structure:
    • Forms a complex with CIRH1A, NOL11, UTP15 and WDR43.
    SequenceCaution:
    • Sequence=BAB14503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR75 Gene

Proteomics data for WDR75 Gene at MOPED

Post-translational modifications for WDR75 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys123, Lys226, Lys281, Lys332, Lys354, Lys466, Lys682, and Lys701

Other Protein References for WDR75 Gene

No data available for DME Specific Peptides for WDR75 Gene

Domains for WDR75 Gene

Gene Families for WDR75 Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR75 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWA0

UniProtKB/Swiss-Prot:

WDR75_HUMAN
Similarity:
  • Contains 9 WD repeats.:
    • Q8IWA0
genes like me logo Genes that share domains with WDR75: view

Function for WDR75 Gene

Gene Ontology (GO) - Molecular Function for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR75: view

Phenotypes for WDR75 Gene

GenomeRNAi human phenotypes for WDR75:
genes like me logo Genes that share phenotypes with WDR75: view

miRNA for WDR75 Gene

miRTarBase miRNAs that target WDR75

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR75 Gene

Localization for WDR75 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR75 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR75 Gene COMPARTMENTS Subcellular localization image for WDR75 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR75 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with WDR75: view

Pathways for WDR75 Gene

genes like me logo Genes that share pathways with WDR75: view

Pathways by source for WDR75 Gene

1 KEGG pathway for WDR75 Gene

Gene Ontology (GO) - Biological Process for WDR75 Gene

None

Transcripts for WDR75 Gene

Unigene Clusters for WDR75 Gene

WD repeat domain 75:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7:
SP8: - -
SP9:
SP10:
SP11:

ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:

Relevant External Links for WDR75 Gene

GeneLoc Exon Structure for
WDR75
ECgene alternative splicing isoforms for
WDR75

Expression for WDR75 Gene

mRNA expression in normal human tissues for WDR75 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR75 Gene

SOURCE GeneReport for Unigene cluster for WDR75 Gene Hs.399984

genes like me logo Genes that share expressions with WDR75: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR75 Gene

Orthologs for WDR75 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR75 35
  • 99.44 (n)
  • 99.52 (a)
WDR75 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR75 35
  • 90.4 (n)
  • 91.81 (a)
WDR75 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR75 35
  • 90.27 (n)
  • 90.83 (a)
WDR75 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr75 35
  • 85.13 (n)
  • 85.01 (a)
Wdr75 16
Wdr75 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR75 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Wdr75 35
  • 84.94 (n)
  • 84.15 (a)
chicken
(Gallus gallus)
Aves WDR75 35
  • 66.42 (n)
  • 61.77 (a)
WDR75 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr75 35
  • 64.72 (n)
  • 59.59 (a)
zebrafish
(Danio rerio)
Actinopterygii siby113d7.2 35
wdr75 35
  • 58.98 (n)
  • 54.25 (a)
wdr75 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007948 35
  • 43.83 (n)
  • 32.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12050 35
  • 43.22 (n)
  • 31.18 (a)
CG12050 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAN1 38
rice
(Oryza sativa)
Liliopsida Os12g0609800 35
  • 42.23 (n)
  • 29.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
CSA.2356 36
  • 30 (a)
OneToMany
Species with no ortholog for WDR75:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR75 Gene

ENSEMBL:
Gene Tree for WDR75 (if available)
TreeFam:
Gene Tree for WDR75 (if available)

Paralogs for WDR75 Gene

Pseudogenes.org Pseudogenes for WDR75 Gene

genes like me logo Genes that share paralogs with WDR75: view

No data available for Paralogs for WDR75 Gene

Variants for WDR75 Gene

Sequence variations from dbSNP and Humsavar for WDR75 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs963738 -- 189,464,127(-) CCTCA(A/G)TGGAA intron-variant
rs966603 -- 189,457,821(-) CATCA(G/T)TACAA intron-variant
rs1224957 -- 189,459,799(-) tcatt(C/T)cctac intron-variant
rs1224958 -- 189,455,264(-) ATGTG(C/T)AAGGA intron-variant
rs1371470 -- 189,448,094(-) ATCAT(A/G)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR75 Gene

Variant ID Type Subtype PubMed ID
nsv875613 CNV Loss 21882294
nsv875615 CNV Gain 21882294
nsv3079 CNV Insertion 18451855
nsv483013 CNV Gain 15286789

Relevant External Links for WDR75 Gene

HapMap Linkage Disequilibrium report
WDR75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR75 Gene

Disorders for WDR75 Gene

(1) University of Copenhagen DISEASES for WDR75 Gene

genes like me logo Genes that share disorders with WDR75: view

No data available for UniProtKB/Swiss-Prot for WDR75 Gene

Publications for WDR75 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PMID: 17699751) Prieto J.L. … McStay B. (Genes Dev. 2007) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for WDR75 Gene

Sources for WDR75 Gene

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