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WDR75 Gene

protein-coding   GIFtS: 50
GCID: GC02P190306

WD Repeat Domain 75

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 751 2     NET162
UTP171 2 3     UTP17, Small Subunit (SSU) Processome Component, Homolog2
Homolog (Yeast)1     WD Repeat-Containing Protein 752
Small Subunit (SSU) Processome Component1     

External Ids:    HGNC: 257251   Entrez Gene: 841282   Ensembl: ENSG000001153687   UniProtKB: Q8IWA03   

Export aliases for WDR75 gene to outside databases

Previous GC identifers: GC02P190132 GC02P190014 GC02P182165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR75 Gene:
WDR75 (WD repeat domain 75) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR75 gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   MIF-1   POU3F2   C/EBPalpha   GATA-6   POU2F1   POU2F1a   FOXO4   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR75 promoter sequence
   Search Chromatin IP Primers for WDR75

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR75


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.2   Ensembl cytogenetic band:  2q32.2   HGNC cytogenetic band: 2q32.2

WDR75 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR75 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P190306:  view genomic region     (about GC identifiers)

Start:
190,306,159 bp from pter      End:
190,340,291 bp from pter
Size:
34,133 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR75_HUMAN, Q8IWA0 (See protein sequence)
Recommended Name: WD repeat-containing protein 75  
Size: 830 amino acids; 94499 Da
Subunit: Forms a complex with CIRH1A, NOL11, UTP15 and WDR43
Sequence caution: Sequence=BAB14503.1; Type=Erroneous initiation;
Secondary accessions: Q96J10 Q9H8U8 Q9H9U5 Q9H9V8 Q9UIX2

Explore the universe of human proteins at neXtProt for WDR75: NX_Q8IWA0

Explore proteomics data for WDR75 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys123, Lys226, Lys281, Lys332, Lys354, Lys466, Lys682, Lys701
  • Modification sites at PhosphoSitePlus

  • See WDR75 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115544.1  
    ENSEMBL proteins: 
     ENSP00000314193   ENSP00000414226   ENSP00000400728  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IWA0

    ProtoNet protein and cluster: Q8IWA0

    UniProtKB/Swiss-Prot: WDR75_HUMAN, Q8IWA0
    Similarity: Contains 9 WD repeats


    Find genes that share domains with WDR75           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with WDR75           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDR75:
     Nuclear 40S maturation defects  Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR75
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR75

    miRNA
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    miRTarBase miRNAs that target WDR75:
    hsa-mir-30a-5p (MIRT028674), hsa-mir-16-5p (MIRT031984), hsa-let-7b-5p (MIRT032487)

    Block miRNA regulation of human, mouse, rat WDR75 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR75_HUMAN, Q8IWA0: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with WDR75           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR75 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with WDR75           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for WDR75):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR75
    Interactions:

        Search GeneGlobe Interaction Network for WDR75

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR75 (Q8IWA03 ENSP000003141934) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    SQSTM1Q135013I2D: score=1 
    CIRH1AENSP000003271794STRING: ENSP00000327179
    HEATR1ENSP000003555414STRING: ENSP00000355541
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR75



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR75 gene: 
    NM_032168.1  

    Unigene Cluster for WDR75:

    WD repeat domain 75
    Hs.399984  [show with all ESTs]
    Unigene Representative Sequence: NM_032168
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314761(uc002uql.1) ENST00000436347(uc002uqm.1) ENST00000472286
    ENST00000475596 ENST00000427960(uc002uqn.1) ENST00000498365
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR75
      QuantiTect SYBR Green Assays in human, mouse, rat WDR75
      QuantiFast Probe-based Assays in human, mouse, rat WDR75

    Additional mRNA sequence: 

    AK022581.1 AK022607.1 AK023276.1 AK091546.1 AK290445.1 AL122097.1 BC006816.1 BC018689.1 
    BC040567.1 

    14 DOTS entries:

    DT.91829838  DT.446724  DT.92472025  DT.95237157  DT.92472079  DT.120981584  DT.95303408  DT.40120929 
    DT.102821711  DT.100814212  DT.40110408  DT.91638668  DT.99956227  DT.40279953 

    Selected AceView cDNA sequences (see all 227):

    NM_032168 BU623595 AA405565 AA425023 BX482715 AA628781 BI766860 AW589745 
    BE672397 BQ231620 CA432523 AA399095 AI122582 AA233467 AW070813 AI017129 
    AK023276 BM479656 H24573 AI538740 AA405606 AI623192 BM804724 BF512154 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR75 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
    SP1:                                -           -                 -     -                 -                                               -                 -   
    SP2:                                -     -     -                 -     -                 -                                               -                 -   
    SP3:                                                                                      -                                                                     
    SP4:                                -     -     -                 -     -                                                                                       
    SP5:                                      -     -                 -     -                                                                                       

    ExUns: 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b
    SP1:                                -           -                                 
    SP2:                                -           -                                 
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for WDR75

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR75 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTAAATT
    WDR75 Expression
    About this image

    WDR75 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR75 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.399984
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR75

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR75 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr751 , 5 WD repeat domain 751, 5 85.13(n)1
    85.01(a)1
      1 (23.87 cM)5
    736741  NM_028599.21  NP_082875.11 
     457951665 
    chicken
    (Gallus gallus)
    Aves WDR751 WD repeat domain 75 66.42(n)
    61.77(a)
      423985  XM_001233407.3  XP_001233408.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    48(a)
    many → 1
    many → 1
    GL343654.1(200239-240042)
    GL344456.1(1029-2574)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr751 WD repeat domain 75 64.72(n)
    59.59(a)
      734119  NM_001045788.1  NP_001039253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii siby113d7.22 siby113d7.2 75.59(n)   368478  BC045446.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120501 CG12050 43.22(n)
    31.18(a)
      35374  NM_136242.4  NP_610086.3 
    rice
    (Oryza sativa)
    Liliopsida Os12g06098001 Os12g0609800 42.23(n)
    29.44(a)
      4352760  NM_001073777.1  NP_001067245.1 


    ENSEMBL Gene Tree for WDR75 (if available)
    TreeFam Gene Tree for WDR75 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR75 gene

    Find genes that share paralogs with WDR75           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WDR75
    PGOHUM00000248147


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR75 (see all 916)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418989291,2
    C--189690781(+) AAGGAA/CAAAAC 1 -- us2k10--------
    rs1455087521,2
    C--189690873(+) GCCCTA/GTTCTG 1 -- us2k10--------
    rs1156715391,2
    F--189690914(+) GACAAC/TGCACT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1380319961,2
    --189691005(+) TGGGCA/GCTTCA 1 -- us2k10--------
    rs1827954151,2
    --189691048(+) TATACA/CTTTAT 1 -- us2k10--------
    rs1879258291,2
    --189691121(+) CCATAC/GAGTAA 1 -- us2k10--------
    rs1923517381,2
    --189691128(+) GTAACA/GTACAA 1 -- us2k10--------
    rs171988571,2
    C,F,H--189691199(+) AAAAGA/CCTGTA 1 -- us2k113Minor allele frequency- N:0.00NA EA NS 878
    rs1417167091,2
    --189691460(+) TCCTCA/CGTAAA 1 -- us2k10--------
    rs757318711,2
    F--189691511(+) GGATAT/CGTCTT 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for WDR75 (190306159 - 190340291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WDR75:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3079CNV Insertion18451855
    nsv875613CNV Loss21882294
    nsv483013CNV Gain15286789
    nsv875615CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR75
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for WDR75:
    Loeys-Dietz syndrome

    Find genes that share disorders with WDR75           About GenesLikeMe


    Export disorders for WDR75 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR75 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with WDR75)
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    1. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PubMed id 17699751)1, 3 Prieto J.L. and McStay B. (amp 2007)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    9. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing. (PubMed id 22916032)2 Freed E.F....Baserga S.J. (PLoS Genet. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84128 HGNC: 25725 AceView: FLJ12519 Ensembl:ENSG00000115368 euGenes: HUgn84128
    ECgene: WDR75 Kegg: 84128 H-InvDB: WDR75

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR75 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR75 gene:
    Search GeneIP for patents involving WDR75

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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