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Aliases for WDR74 Gene

Aliases for WDR74 Gene

  • WD Repeat Domain 74 2 3 5
  • NOP Seven-Associated Protein 1 4
  • NSA1 4

External Ids for WDR74 Gene

Previous GeneCards Identifiers for WDR74 Gene

  • GC11M062357
  • GC11M062600
  • GC11M058929

Summaries for WDR74 Gene

GeneCards Summary for WDR74 Gene

WDR74 (WD Repeat Domain 74) is a Protein Coding gene.

Additional gene information for WDR74 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR74 Gene

Genomics for WDR74 Gene

Regulatory Elements for WDR74 Gene

Enhancers for WDR74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062838 1.5 ENCODE dbSUPER 81.8 +1.0 964 4.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
GH11H061960 1.8 FANTOM5 ENCODE dbSUPER 44.5 +872.9 872886 16.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D UBXN1 LOC105369332 WDR74 INTS5 MTA2 CPSF7 TMEM138 NXF1 EML3 STX5
GH11H062669 1.1 ENCODE 55.4 +170.3 170321 4.2 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 EML3 WDR74 LOC105369332 GANAB MTA2 STX5 INTS5 METTL12 NXF1 SNHG1
GH11H062852 1.7 FANTOM5 ENCODE dbSUPER 32.3 -14.0 -14029 5.9 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SNHG1 METTL12 NXF1 MTA2 GANAB INTS5 UBXN1 EML3 STX5 LOC105369332
GH11H062551 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +284.6 284633 12.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF207 EML3 TUT1 MTA2 TAF6L NXF1 LOC105369332 WDR74 STX5 INTS5 TTC9C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR74 on UCSC Golden Path with GeneCards custom track

Promoters for WDR74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040481 1309 3801 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC

Transcription factor binding sites by QIAGEN in the WDR74 gene promoter:

Genomic Locations for WDR74 Gene

Genomic Locations for WDR74 Gene
chr11:62,832,342-62,841,809
(GRCh38/hg38)
Size:
9,468 bases
Orientation:
Minus strand
chr11:62,599,814-62,609,281
(GRCh37/hg19)

Genomic View for WDR74 Gene

Genes around WDR74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR74 Gene

Proteins for WDR74 Gene

  • Protein details for WDR74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RFH5-WDR74_HUMAN
    Recommended name:
    WD repeat-containing protein 74
    Protein Accession:
    Q6RFH5
    Secondary Accessions:
    • A8K8G5
    • Q9BRC9
    • Q9H6X8
    • Q9NVY2

    Protein attributes for WDR74 Gene

    Size:
    385 amino acids
    Molecular mass:
    42441 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR74 Gene

Post-translational modifications for WDR74 Gene

  • Ubiquitination at posLast=6868, posLast=151151, posLast=156156, posLast=197197, Lys266, Lys281, and Lys359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR74 Gene

Domains & Families for WDR74 Gene

Gene Families for WDR74 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR74 Gene

Suggested Antigen Peptide Sequences for WDR74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR74: view

No data available for UniProtKB/Swiss-Prot for WDR74 Gene

Function for WDR74 Gene

Phenotypes From GWAS Catalog for WDR74 Gene

Gene Ontology (GO) - Molecular Function for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR74: view
genes like me logo Genes that share phenotypes with WDR74: view

Animal Model Products

miRNA for WDR74 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR74 Gene

Localization for WDR74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR74 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR74 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA,IEA 12429849
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with WDR74: view

Pathways & Interactions for WDR74 Gene

SuperPathways for WDR74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR74: view

No data available for Pathways by source and SIGNOR curated interactions for WDR74 Gene

Drugs & Compounds for WDR74 Gene

No Compound Related Data Available

Transcripts for WDR74 Gene

Unigene Clusters for WDR74 Gene

WD repeat domain 74:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for WDR74 Gene

GeneLoc Exon Structure for
WDR74
ECgene alternative splicing isoforms for
WDR74

Expression for WDR74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR74 Gene

This gene is overexpressed in Lung (30.3), Peripheral blood mononuclear cells (10.6), CD8 Tcells (8.1), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR74 Gene



Protein tissue co-expression partners for WDR74 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR74 Gene:

WDR74

SOURCE GeneReport for Unigene cluster for WDR74 Gene:

Hs.654620

Evidence on tissue expression from TISSUES for WDR74 Gene

  • Muscle(4.3)
  • Liver(4.2)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with WDR74: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR74 Gene

Orthologs for WDR74 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR74 33 34
  • 89.84 (n)
dog
(Canis familiaris)
Mammalia WDR74 33 34
  • 89.12 (n)
mouse
(Mus musculus)
Mammalia Wdr74 33 16 34
  • 86.2 (n)
rat
(Rattus norvegicus)
Mammalia Wdr74 33
  • 85.48 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR74 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR74 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR74 33 34
  • 63.04 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr74 33
  • 58.22 (n)
Str.10972 33
zebrafish
(Danio rerio)
Actinopterygii wdr74 33 34
  • 58.67 (n)
Dr.17925 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8665 33
fruit fly
(Drosophila melanogaster)
Insecta CG7845 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T06E6.1 33
  • 48.06 (n)
T06E6.1 34
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA1 36
Species where no ortholog for WDR74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR74 Gene

ENSEMBL:
Gene Tree for WDR74 (if available)
TreeFam:
Gene Tree for WDR74 (if available)

Paralogs for WDR74 Gene

No data available for Paralogs for WDR74 Gene

Variants for WDR74 Gene

Sequence variations from dbSNP and Humsavar for WDR74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000234135 -- 62,841,665(+) ATGCG(C/G/T)GGAGT upstream-variant-2KB, utr-variant-5-prime
rs1000637928 -- 62,837,191(+) TCATC(C/T)TGTAT intron-variant
rs1000801544 -- 62,838,752(+) AAAAC(C/T)CCGTC intron-variant
rs1000871249 -- 62,833,991(+) CCATT(A/C)ATTGT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001574882 -- 62,840,112(+) TTCTT(C/T)TGCCT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR74 Gene

Variant ID Type Subtype PubMed ID
nsv952461 CNV deletion 24416366
nsv509416 CNV insertion 20534489
nsv508636 CNV deletion 20534489
nsv1159903 CNV duplication 26073780
nsv1122629 CNV deletion 24896259
esv991674 OTHER inversion 20482838

Variation tolerance for WDR74 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR74 Gene

Disorders for WDR74 Gene

Relevant External Links for WDR74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR74

No disorders were found for WDR74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR74 Gene

Publications for WDR74 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. (PMID: 28416111) Lo YH … Stanley RE (Structure (London, England : 1993) 2017) 3 60

Products for WDR74 Gene

Sources for WDR74 Gene

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