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Aliases for WDR74 Gene

Aliases for WDR74 Gene

  • WD Repeat Domain 74 2 3 5
  • NOP Seven-Associated Protein 1 4
  • NSA1 4

External Ids for WDR74 Gene

Previous GeneCards Identifiers for WDR74 Gene

  • GC11M062357
  • GC11M062600
  • GC11M058929

Summaries for WDR74 Gene

GeneCards Summary for WDR74 Gene

WDR74 (WD Repeat Domain 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR74 Gene

Genomics for WDR74 Gene

Regulatory Elements for WDR74 Gene

Enhancers for WDR74 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR74 on UCSC Golden Path with GeneCards custom track

Promoters for WDR74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR74 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the WDR74 gene promoter:

Genomic Location for WDR74 Gene

62,832,342 bp from pter
62,841,809 bp from pter
9,468 bases
Minus strand

Genomic View for WDR74 Gene

Genes around WDR74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR74 Gene

Proteins for WDR74 Gene

  • Protein details for WDR74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 74
    Protein Accession:
    Secondary Accessions:
    • A8K8G5
    • Q9BRC9
    • Q9H6X8
    • Q9NVY2

    Protein attributes for WDR74 Gene

    385 amino acids
    Molecular mass:
    42441 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR74 Gene


neXtProt entry for WDR74 Gene

Proteomics data for WDR74 Gene at MOPED

Post-translational modifications for WDR74 Gene

  • Ubiquitination at Lys 68, Lys 151, Lys 156, Lys 197, Lys 266, Lys 281, and Lys 359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR74 Gene

Domains & Families for WDR74 Gene

Gene Families for WDR74 Gene

Protein Domains for WDR74 Gene

Suggested Antigen Peptide Sequences for WDR74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 WD repeats.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR74: view

Function for WDR74 Gene

genes like me logo Genes that share phenotypes with WDR74: view

Animal Model Products

miRNA for WDR74 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR74 Gene

Localization for WDR74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR74 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for WDR74 Gene COMPARTMENTS Subcellular localization image for WDR74 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
genes like me logo Genes that share ontologies with WDR74: view

Pathways & Interactions for WDR74 Gene

SuperPathways for WDR74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR74: view

No data available for Pathways by source and SIGNOR curated interactions for WDR74 Gene

Drugs & Compounds for WDR74 Gene

No Compound Related Data Available

Transcripts for WDR74 Gene

Unigene Clusters for WDR74 Gene

WD repeat domain 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP8: -

Relevant External Links for WDR74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR74 Gene

mRNA expression in normal human tissues for WDR74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR74 Gene

This gene is overexpressed in Lung (30.3), Peripheral blood mononuclear cells (10.6), CD8 Tcells (8.1), and Blymphocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR74 Gene

SOURCE GeneReport for Unigene cluster for WDR74 Gene Hs.654620

genes like me logo Genes that share expression patterns with WDR74: view

Protein tissue co-expression partners for WDR74 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR74 Gene

Orthologs for WDR74 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR74 35
  • 89.84 (n)
  • 92.19 (a)
WDR74 36
  • 92 (a)
(Canis familiaris)
Mammalia WDR74 35
  • 89.12 (n)
  • 91.05 (a)
WDR74 36
  • 90 (a)
(Mus musculus)
Mammalia Wdr74 35
  • 86.2 (n)
  • 89.58 (a)
Wdr74 16
Wdr74 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Wdr74 35
  • 85.48 (n)
  • 89.86 (a)
(Monodelphis domestica)
Mammalia WDR74 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia WDR74 36
  • 53 (a)
(Gallus gallus)
Aves WDR74 35
  • 63.04 (n)
  • 64.36 (a)
WDR74 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10972 35
wdr74 35
  • 58.22 (n)
  • 56.68 (a)
(Danio rerio)
Actinopterygii Dr.17925 35
wdr74 35
  • 58.67 (n)
  • 52.32 (a)
wdr74 36
  • 50 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8665 35
fruit fly
(Drosophila melanogaster)
Insecta CG7845 36
  • 25 (a)
(Caenorhabditis elegans)
Secernentea CELE_T06E6.1 35
  • 48.06 (n)
  • 39.53 (a)
T06E6.1 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA1 38
Species with no ortholog for WDR74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR74 Gene

Gene Tree for WDR74 (if available)
Gene Tree for WDR74 (if available)

Paralogs for WDR74 Gene

No data available for Paralogs for WDR74 Gene

Variants for WDR74 Gene

Sequence variations from dbSNP and Humsavar for WDR74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs527481 -- 62,836,440(-) ACAGA(C/T)CAGTA intron-variant
rs2289574 -- 62,834,665(+) ATGTA(C/T)GCCTC intron-variant
rs2298635 -- 62,835,575(-) CACAT(A/C/T)GAGCC intron-variant
rs2298636 -- 62,835,511(-) TGGAC(C/T)TGCGG reference, synonymous-codon
rs112966057 -- 62,838,761(+) TCTCC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR74 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
esv991674 OTHER Inversion 20482838

Variation tolerance for WDR74 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR74 Gene

Disorders for WDR74 Gene

Relevant External Links for WDR74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR74 Gene

Publications for WDR74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. (PMID: 26456651) Hiraishi N. … Nagahama M. (Biochem. Biophys. Res. Commun. 2015) 3

Products for WDR74 Gene

Sources for WDR74 Gene