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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR74 Gene

protein-coding   GIFtS: 46
GCID: GC11M062600

WD Repeat Domain 74

  Search for WDR74
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 741 2
NOP Seven-Associated Protein 12 3
WD Repeat-Containing Protein 742
NSA13

External Ids:    HGNC: 255291   Entrez Gene: 546632   Ensembl: ENSG000001333167   UniProtKB: Q6RFH53   

Export aliases for WDR74 gene to outside databases

Previous GC identifers: GC11M062357 GC11M058929


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR74 Gene: 
WDR74 (WD repeat domain 74) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR74 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR74 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR74

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

WDR74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR74 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062600:  view genomic region     (about GC identifiers)

Start:
62,599,814 bp from pter      End:
62,609,281 bp from pter
Size:
9,468 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5 (See protein sequence)
Recommended Name: WD repeat-containing protein 74  
Size: 385 amino acids; 42441 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: A8K8G5 Q9BRC9 Q9H6X8 Q9NVY2
Alternative splicing: 2 isoforms:  Q6RFH5-1   Q6RFH5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR74: NX_Q6RFH5

Explore proteomics data for WDR74 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6RFH5

  • WDR74 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR74 Protein Expression
    REFSEQ proteins: NP_060563.2  
    ENSEMBL proteins: 
     ENSP00000439541   ENSP00000308931   ENSP00000435726   ENSP00000432119   ENSP00000432113  
     ENSP00000438700   ENSP00000440612   ENSP00000278856  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for WDR74 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IDA12429849

    WDR74 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6RFH5

    ProtoNet protein and cluster: Q6RFH5

    UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5
    Similarity: Contains 6 WD repeats


    WDR74 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    WDR74 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR74:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR74 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR74

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for WDR74 (Q6RFH52, 3 ENSP000002788564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT3O959892, 3MINT-8265076 I2D: score=2 
    RGS2P412202, 3, ENSP000002353824MINT-63733 MINT-8268988 I2D: score=5 STRING: ENSP00000235382
    CALRP277973I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    GTPBP4ENSP000003540404STRING: ENSP00000354040
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001825blastocyst formation IEA--
    GO:0008150biological_process ND--
    GO:0016070RNA metabolic process IEA--

    WDR74 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR74

    Search CenterWatch for drugs/clinical trials and news about WDR74

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR74 gene: 
    NM_018093.2  

    Unigene Cluster for WDR74:

    WD repeat domain 74
    Hs.654620  [show with all ESTs]
    Unigene Representative Sequence: AK292330
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536401 ENST00000311713 ENST00000529106(uc001nvm.2) ENST00000525239(uc009yoi.2)
    ENST00000525752 ENST00000544831 ENST00000543688 ENST00000542347 ENST00000541930
    ENST00000540620 ENST00000538150 ENST00000545112(uc010rmk.2) ENST00000453708
    ENST00000544953 ENST00000538277 ENST00000538098 ENST00000278856(uc001nvl.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR74
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR74:
    hsa-miR-520d-5p hsa-miR-524-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: WDR74 (NM_018093)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR74

    Additional mRNA sequence: 

    AK001301.1 AK025383.1 AK292330.1 AK303186.1 AY500828.1 BC006351.2 

    13 DOTS entries:

    DT.447847  DT.99991199  DT.100822865  DT.95136636  DT.102841763  DT.95136634  DT.100822862  DT.100822866 
    DT.95136632  DT.100027409  DT.100696607  DT.100822863  DT.40132663 

    24/46 AceView cDNA sequences (see all 46):

    AL542365 AA030018 AL528433 AA029763 BX363339 BX363340 AL524767 T47648 
    D11665 BI088892 AI826482 AW118035 CB217240 BU752839 R18464 BF883374 
    W37368 AW952829 W37367 BQ676725 BG201423 AW956413 AW883987 BG490985 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -                             -                 -     -                                       
    SP2:                                -                             -                 -     -                             -         
    SP3:                                                              -                 -     -                                       
    SP4:                          -     -                                                                                             
    SP5:                                -                                                                                             


    ECgene alternative splicing isoforms for WDR74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCTGGC
    WDR74 Expression
    About this image


    See WDR74 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR74

    SOURCE GeneReport for Unigene cluster: Hs.654620
        SABiosciences Custom PCR Arrays for WDR74
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WDR74 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr741 , 5 WD repeat domain 741, 5 86.2(n)1
    89.58(a)1
      19 (5.44 cM)5
    1070711  NM_134139.11  NP_598900.11 
     87358395 
    chicken
    (Gallus gallus)
    Aves LOC1008586211 WD repeat-containing protein 74-like 62.33(n)
    64(a)
      100858621  XM_003643796.1  XP_003643844.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.109722 Transcribed sequence with weak similarity to protein more 77.87(n)    CF242309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179252 Transcribed sequence with weak similarity to protein more 71.93(n)    BI984242.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78456
    --
    26(a)
    1 ↔ 1
    2R(1961976-1963882)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T06E6.11 Protein T06E6.1 47.66(n)
    38.01(a)
      180039  NM_074423.3  NP_506824.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NSA1(YGL111W)4 Constituent of 66S pre-ribosomal particles, involved more   --   7(299978-301369) 852767  NP_011404.1 


    ENSEMBL Gene Tree for WDR74 (if available)
    TreeFam Gene Tree for WDR74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 SNPs in WDR74 are shown (see all 166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125742451,2
    C,H--62601565(+) GGAAAA/CTAAGG 1 -- int10--------
    rs2010263741,2
    C--62601747(+) ACTCAC/TCTTGC 1 -- spd10--------
    rs1996077721,2
    C--62601751(+) ACCTTA/GCCGAA 2 Q * stg10--------
    rs1845002311,2
    --62601851(+) CTGGAA/GCCCTT 1 -- int10--------
    rs2008860051,2
    C--62601927(+) GGCTGG/TTNNNN 2 T P mis10--------
    rs2000010301,2
    --62601968(+) GCCGGC/TGCTGG 2 H R mis10--------
    rs1143982631,2
    C,F--62602036(+) CCTCAC/ACCTGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs763205911,2
    C,F--62602133(+) TTAGAT/CGTATG 1 -- int13Minor allele frequency- C:0.08WA 122
    rs22895741,2
    C,F,O,H--62602137(+) ATGTAT/CGCCTC 1 -- int123Minor allele frequency- C:0.13EA NA NS WA 4396
    rs37940451,2
    C,F,H--62602345(+) AAGGAG/CGAAAG 1 -- int1 trp38Minor allele frequency- C:0.13EA NS WA NA 2266

    HapMap Linkage Disequilibrium report for WDR74 (62599814 - 62609281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WDR74:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294
    esv991674OTHER Inversion20482838

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for WDR74

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR74 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with WDR74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    4. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54663 HGNC: 25529 AceView: FLJ10439 Ensembl:ENSG00000133316 euGenes: HUgn54663
    ECgene: WDR74 H-InvDB: WDR74

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR74 gene:
    Search GeneIP for patents involving WDR74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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