WDR74 Gene
protein-coding GIFtS: 46
GCID: GC11M062600
|
|
WD repeat domain 74
| |
Aliases for WDR74 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| WD Repeat Domain 741 2 | | NOP Seven-Associated Protein 12 3 | | FLJ104391 | | WD Repeat-Containing Protein 742 | | NSA13 |
Export aliases for WDR74 gene to outside databasesPrevious GC identifers: GC11M062357 GC11M058929 |
Summaries for WDR74 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for WDR74 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDR74 gene promoter: AP-1 ATF-2 c-Jun Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR74
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR74 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.3 Ensembl cytogenetic band: 11q12.3 HGNC cytogenetic band: 11q12.3WDR74 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M062600: view genomic region
(about GC identifiers)
Start:
|
62,599,814 bp from pter |
End:
|
62,609,281 bp from pter |
Size:
|
9,468 bases |
Orientation:
|
minus strand |
|
Proteins for WDR74 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5 (See
protein sequence)Recommended Name: WD repeat-containing protein 74 Size: 385 amino acids; 42441 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: A8K8G5 Q9BRC9 Q9H6X8 Q9NVY2Alternative splicing: 2 isoforms: Q6RFH5-1 Q6RFH5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR74: NX_Q6RFH5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6RFH5 WDR74 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060563.2 ENSEMBL proteins: ENSP00000439541 ENSP00000308931 ENSP00000435726 ENSP00000432119 ENSP00000443863 ENSP00000432113 ENSP00000438700 ENSP00000440612 ENSP00000278856 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WDR74 for ontologies About GeneDecksing
WDR74 Antibody Products: Assay Products for WDR74: |
Protein
Domains / Families for WDR74 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR74 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6RFH5ProtoNet protein and cluster: Q6RFH5 UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5Similarity: Contains 6 WD repeats |
Function for WDR74 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR74 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR74 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR74 (NM_018093) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR74 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR74  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
WDR74 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for WDR74:
|
Pathways & Interactions for WDR74 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR74
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
 5/14 Interacting proteins for WDR74 (Q6RFH52, 3 ENSP000002788564) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
WDR74 for ontologies About GeneDecksing
|
Drugs & Compounds for WDR74 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for WDR74 Search CenterWatch for drugs/clinical trials and news about WDR74 
|
Transcripts for WDR74 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WDR74 gene: NM_018093.2 Unigene Cluster for WDR74: WD repeat domain 74 Hs.654620 [show with all ESTs]Unigene Representative Sequence: AK29233018 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000536401 ENST00000311713 ENST00000529106(uc001nvm.2) ENST00000525239(uc009yoi.2) ENST00000535048 ENST00000525752 ENST00000544831 ENST00000543688 ENST00000542347 ENST00000541930 ENST00000540620 ENST00000538150 ENST00000545112(uc010rmk.2) ENST00000453708 ENST00000544953 ENST00000538277 ENST00000538098 ENST00000278856(uc001nvl.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR74 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR74 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR74 (NM_018093) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR74 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR74  |
Additional cDNA sequence: AK001301.1 AK025383.1 AK292330.1 AK303186.1 AY500828.1 BC006351.2 13 DOTS entries: DT.447847 DT.99991199 DT.100822865 DT.95136636 DT.102841763 DT.95136634 DT.100822862 DT.100822866 DT.95136632 DT.100027409 DT.100696607 DT.100822863 DT.40132663 24/46 AceView cDNA sequences (see all 46): AL542365 AA030018 AL528433 AA029763 BX363339 BX363340 AL524767 T47648 D11665 CB217240 BI088892 BU752839 AI826482 AW118035 BG201423 W37367 W37368 AW952829 BF883374 AW956413 BQ676725 AW883987 R18464 T47647 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for WDR74
|
Expression for WDR74 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR74 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCAGCTGGC
About this image See WDR74 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDR74
SOURCE GeneReport for Unigene cluster: Hs.654620 SABiosciences Custom PCR Arrays for WDR74
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR74 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR74 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR74 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR74 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74 |
Orthologs for WDR74 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR74 gene from 8/24 species (see all 24) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Wdr741 , 5 |
WD repeat domain 741, 5 |
86.2(n)1 89.58(a)1 |
  |
19 (5.44 cM)5 1070711 NM_134139.11 NP_598900.11 87358395 |
chicken (Gallus gallus) |
Aves |
LOC1008586211 |
WD repeat-containing protein 74-like |
62.33(n) 64(a) |
  |
100858621 XM_003643796.1 XP_003643844.1 |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.109722 |
Transcribed sequence with weak similarity to protein more |
77.87(n) |
  |
CF242309.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.179252 |
Transcribed sequence with weak similarity to protein more |
71.93(n) |
  |
BI984242.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
CG78456 |
-- |
24(a) |
1 ↔ 1 |
2R(1961976-1963882) |
worm (Caenorhabditis elegans) |
Secernentea |
CELE_T06E6.11 |
Protein T06E6.1 |
47.66(n) 38.01(a) |
  |
180039 NM_074423.3 NP_506824.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT1G293206 |
WD40 domain-containing protein |
20(a) |
1 ↔ 1 |
1(10255321-10258343) |
rice (Oryza sativa) |
Liliopsida |
-- |
WD domain, G-beta repeat domain containing protein... |
22(a) |
1 ↔ 1 |
7(19230655-19235051) |
ENSEMBL Gene Tree for WDR74 (if available) TreeFam Gene Tree for WDR74 (if available)  |
Paralogs for WDR74 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for WDR74 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR74 (62599814 - 62609281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for WDR74 1 CNV: 0150  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR74 |
|
Disorders
/ Diseases for WDR74 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for WDR74 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR74 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with WDR74) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
|
External Searches for WDR74 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR74 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR74 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR74 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for WDR74 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR74 gene: Search GeneIP for patents involving WDR74
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for WDR74 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | WDR74 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74 |
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