Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR74 Gene

Aliases for WDR74 Gene

  • WD Repeat Domain 74 2 3
  • NOP Seven-Associated Protein 1 4
  • NSA1 4

External Ids for WDR74 Gene

Previous GeneCards Identifiers for WDR74 Gene

  • GC11M062357
  • GC11M062600
  • GC11M058929

Summaries for WDR74 Gene

GeneCards Summary for WDR74 Gene

WDR74 (WD Repeat Domain 74) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR74 Gene

Genomics for WDR74 Gene

Regulatory Elements for WDR74 Gene

Transcription factor binding sites by QIAGEN in the WDR74 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR74 Gene

Start:
62,832,342 bp from pter
End:
62,841,809 bp from pter
Size:
9,468 bases
Orientation:
Minus strand

Genomic View for WDR74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR74 Gene

Proteins for WDR74 Gene

  • Protein details for WDR74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6RFH5-WDR74_HUMAN
    Recommended name:
    WD repeat-containing protein 74
    Protein Accession:
    Q6RFH5
    Secondary Accessions:
    • A8K8G5
    • Q9BRC9
    • Q9H6X8
    • Q9NVY2

    Protein attributes for WDR74 Gene

    Size:
    385 amino acids
    Molecular mass:
    42441 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR74 Gene

Proteomics data for WDR74 Gene at MOPED

Post-translational modifications for WDR74 Gene

  • Ubiquitination at Lys68, Lys151, Lys156, Lys197, Lys266, Lys281, Lys311, and Lys359
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WDR74 Gene

Domains for WDR74 Gene

Gene Families for WDR74 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR74 Gene

Suggested Antigen Peptide Sequences for WDR74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6RFH5

UniProtKB/Swiss-Prot:

WDR74_HUMAN :
  • Q6RFH5
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR74: view

Function for WDR74 Gene

Gene Ontology (GO) - Molecular Function for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR74: view

Phenotypes for WDR74 Gene

GenomeRNAi human phenotypes for WDR74:
genes like me logo Genes that share phenotypes with WDR74: view

Animal Model Products

miRNA for WDR74 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR74

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR74 Gene

Localization for WDR74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR74 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR74 Gene COMPARTMENTS Subcellular localization image for WDR74 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with WDR74: view

Pathways for WDR74 Gene

SuperPathways for WDR74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001825 blastocyst formation IEA --
GO:0008150 biological_process ND --
GO:0016070 RNA metabolic process IEA --
genes like me logo Genes that share ontologies with WDR74: view

No data available for Pathways by source for WDR74 Gene

Transcripts for WDR74 Gene

Unigene Clusters for WDR74 Gene

WD repeat domain 74:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR74

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8: -

Relevant External Links for WDR74 Gene

GeneLoc Exon Structure for
WDR74
ECgene alternative splicing isoforms for
WDR74

Expression for WDR74 Gene

mRNA expression in normal human tissues for WDR74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for WDR74 Gene

This gene is overexpressed in Lung (30.3), Peripheral blood mononuclear cells (10.6), CD8 Tcells (8.1), and Blymphocyte (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR74 Gene

SOURCE GeneReport for Unigene cluster for WDR74 Gene Hs.654620

genes like me logo Genes that share expressions with WDR74: view

Expression partners for WDR74 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR74 Gene

Orthologs for WDR74 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR74 35
  • 89.84 (n)
  • 92.19 (a)
WDR74 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR74 35
  • 89.12 (n)
  • 91.05 (a)
WDR74 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr74 35
  • 86.2 (n)
  • 89.58 (a)
Wdr74 16
Wdr74 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr74 35
  • 85.48 (n)
  • 89.86 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR74 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR74 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR74 35
  • 63.04 (n)
  • 64.36 (a)
WDR74 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10972 35
wdr74 35
  • 58.22 (n)
  • 56.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17925 35
wdr74 35
  • 58.67 (n)
  • 52.32 (a)
wdr74 36
  • 50 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8665 35
fruit fly
(Drosophila melanogaster)
Insecta CG7845 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T06E6.1 35
  • 48.06 (n)
  • 39.53 (a)
T06E6.1 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSA1 38
Species with no ortholog for WDR74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR74 Gene

ENSEMBL:
Gene Tree for WDR74 (if available)
TreeFam:
Gene Tree for WDR74 (if available)

Paralogs for WDR74 Gene

No data available for Paralogs for WDR74 Gene

Variants for WDR74 Gene

Sequence variations from dbSNP and Humsavar for WDR74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474209 -- 62,837,595(-) ACTGG(A/G)GGCAT intron-variant
rs527481 -- 62,836,440(-) ACAGA(C/T)CAGTA intron-variant
rs2289574 -- 62,834,665(+) ATGTA(C/T)GCCTC intron-variant
rs2298635 -- 62,835,575(-) CACAT(A/C)GAGCC intron-variant
rs2298636 -- 62,835,511(-) TGGAC(C/T)TGCGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for WDR74 Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
esv991674 OTHER Inversion 20482838

Relevant External Links for WDR74 Gene

HapMap Linkage Disequilibrium report
WDR74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR74 Gene

Disorders for WDR74 Gene

No disorders were found for WDR74 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for WDR74 Gene

Publications for WDR74 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PMID: 14742713) Eilbracht J. … Schmidt-Zachmann M.S. (Mol. Biol. Cell 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for WDR74 Gene

Sources for WDR74 Gene

Back to Top

Content