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WDR74 Gene

protein-coding   GIFtS: 49
GCID: GC11M062600

WD Repeat Domain 74

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 741 2
NOP Seven-Associated Protein 12 3
WD Repeat-Containing Protein 742
NSA13

External Ids:    HGNC: 255291   Entrez Gene: 546632   Ensembl: ENSG000001333167   UniProtKB: Q6RFH53   

Export aliases for WDR74 gene to outside databases

Previous GC identifers: GC11M062357 GC11M058929


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR74 Gene:
WDR74 (WD repeat domain 74) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR74 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR74 promoter sequence
   Search Chromatin IP Primers for WDR74

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

WDR74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR74 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062600:  view genomic region     (about GC identifiers)

Start:
62,599,814 bp from pter      End:
62,609,281 bp from pter
Size:
9,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5 (See protein sequence)
Recommended Name: WD repeat-containing protein 74  
Size: 385 amino acids; 42441 Da
Secondary accessions: A8K8G5 Q9BRC9 Q9H6X8 Q9NVY2
Alternative splicing: 2 isoforms:  Q6RFH5-1   Q6RFH5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR74: NX_Q6RFH5

Explore proteomics data for WDR74 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys68, Lys151, Lys156, Lys197, Lys266, Lys281, Lys311, Lys359
  • Modification sites at PhosphoSitePlus

  • See WDR74 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060563.2  
    ENSEMBL proteins: 
     ENSP00000439541   ENSP00000308931   ENSP00000435726   ENSP00000432119   ENSP00000432113  
     ENSP00000438700   ENSP00000440612   ENSP00000278856  

    WDR74 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WDR74

     
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    antibodies-online proteins for WDR74 (2 products) 

     
    antibodies-online peptides for WDR74

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    antibodies-online antibodies for WDR74 (14 products) 

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    Cloud-Clone Corp. ELISAs for WDR74
    Cloud-Clone Corp. CLIAs for WDR74
    Search eBioscience for ELISAs for WDR74 
    antibodies-online kits for WDR74 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6RFH5

    ProtoNet protein and cluster: Q6RFH5

    UniProtKB/Swiss-Prot: WDR74_HUMAN, Q6RFH5
    Similarity: Contains 6 WD repeats


    Find genes that share domains with WDR74           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR74           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR74:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDR74

    miRNA
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    miRTarBase miRNAs that target WDR74:
    hsa-mir-30a-5p (MIRT028577), hsa-mir-98-5p (MIRT027617), hsa-mir-10a-5p (MIRT047671), hsa-let-7b-5p (MIRT032316)

    Block miRNA regulation of human, mouse, rat WDR74 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WDR74:
    hsa-miR-520d-5p hsa-miR-524-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR74

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR74_HUMAN, Q6RFH5: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with WDR74           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR74
    Interactions:

        Search GeneGlobe Interaction Network for WDR74

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR74 (Q6RFH52, 3 ENSP000002788564) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUDT3O959892, 3MINT-8265076 I2D: score=2 
    RGS2P412202, 3, ENSP000002353824MINT-63733 MINT-8268988 I2D: score=5 STRING: ENSP00000235382
    CALRP277973I2D: score=2 
    EIF6ENSP000003635594STRING: ENSP00000363559
    GTPBP4ENSP000003540404STRING: ENSP00000354040
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001825blastocyst formation IEA--
    GO:0008150biological_process ND--
    GO:0016070RNA metabolic process IEA--

    Find genes that share ontologies with WDR74           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR74



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR74 gene: 
    NM_018093.2  

    Unigene Cluster for WDR74:

    WD repeat domain 74
    Hs.654620  [show with all ESTs]
    Unigene Representative Sequence: AK292330
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536401 ENST00000311713 ENST00000529106(uc001nvm.2) ENST00000525239(uc009yoi.2)
    ENST00000525752 ENST00000544831 ENST00000543688 ENST00000542347 ENST00000541930
    ENST00000540620 ENST00000538150 ENST00000545112(uc010rmk.2) ENST00000453708
    ENST00000544953 ENST00000538277 ENST00000538098 ENST00000278856(uc001nvl.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR74 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WDR74:
    hsa-miR-520d-5p hsa-miR-524-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR74
    Predesigned siRNA for gene silencing in human, mouse, rat WDR74
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    GenScript: all cDNA clones in your preferred vector: WDR74 (NM_018093)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR74
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WDR74
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR74
      QuantiTect SYBR Green Assays in human, mouse, rat WDR74
      QuantiFast Probe-based Assays in human, mouse, rat WDR74

    Additional mRNA sequence: 

    AK001301.1 AK025383.1 AK292330.1 AK303186.1 AY500828.1 BC006351.2 

    13 DOTS entries:

    DT.447847  DT.99991199  DT.100822865  DT.95136636  DT.102841763  DT.95136634  DT.100822862  DT.100822866 
    DT.95136632  DT.100027409  DT.100696607  DT.100822863  DT.40132663 

    Selected AceView cDNA sequences (see all 46):

    AL542365 AL528433 AA030018 AL524767 BX363340 BX363339 AA029763 D11665 
    T47648 AW118035 CB217240 AI826482 BI088892 BU752839 BQ676725 AW956413 
    W37367 AW952829 BG201423 AW883987 BF883374 R18464 W37368 BU162943 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR74 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -                             -                 -     -                                       
    SP2:                                -                             -                 -     -                             -         
    SP3:                                                              -                 -     -                                       
    SP4:                          -     -                                                                                             
    SP5:                                -                                                                                             


    ECgene alternative splicing isoforms for WDR74

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR74 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCTGGC
    WDR74 Expression
    About this image


    WDR74 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    WDR74 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR74 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654620
        Custom PCR Arrays for WDR74
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR74

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR74 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr741 , 5 WD repeat domain 741, 5 86.2(n)1
    89.58(a)1
      19 (5.44 cM)5
    1070711  NM_134139.11  NP_598900.11 
     87358395 
    chicken
    (Gallus gallus)
    Aves WDR741 WD repeat domain 74 63.04(n)
    64.36(a)
      100858621  XM_003643796.2  XP_003643844.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.109722 Transcribed sequence with weak similarity to protein more 77.87(n)    CF242309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179252 Transcribed sequence with weak similarity to protein more 71.93(n)    BI984242.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78456
    --
    25(a)
    1 ↔ 1
    2R(1961976-1963882)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T06E6.11 CELE_T06E6.1 48.06(n)
    39.53(a)
      180039  NM_074423.4  NP_506824.1 


    ENSEMBL Gene Tree for WDR74 (if available)
    TreeFam Gene Tree for WDR74 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR74 (see all 166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125742451,2
    C,H--62601565(+) GGAAAA/CTAAGG 1 -- int10--------
    rs2010263741,2
    C--62601747(+) ACTCAC/TCTTGC 1 -- spd10--------
    rs1996077721,2
    C--62601751(+) ACCTTA/GCCGAA 2 Q * stg10--------
    rs1845002311,2
    --62601851(+) CTGGAA/GCCCTT 1 -- int10--------
    rs2008860051,2
    C--62601927(+) GGCTGG/TTNNNN 2 T P mis10--------
    rs2000010301,2
    --62601968(+) GCCGGC/TGCTGG 2 H R mis10--------
    rs1143982631,2
    C,F--62602036(+) CCTCAC/ACCTGC 1 -- int11Minor allele frequency- A:0.02WA 118
    rs763205911,2
    C,F--62602133(+) TTAGAT/CGTATG 1 -- int13Minor allele frequency- C:0.08WA 122
    rs22895741,2
    C,F,O,H--62602137(+) ATGTAT/CGCCTC 1 -- int123Minor allele frequency- C:0.13EA NA NS WA 4396
    rs37940451,2
    C,F,H--62602345(+) AAGGAG/CGAAAG 1 -- int1 trp38Minor allele frequency- C:0.13EA NS WA NA 2266

    HapMap Linkage Disequilibrium report for WDR74 (62599814 - 62609281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for WDR74:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294
    esv991674OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR74
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR74

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR74 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with WDR74)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    4. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54663 HGNC: 25529 AceView: FLJ10439 Ensembl:ENSG00000133316 euGenes: HUgn54663
    ECgene: WDR74 H-InvDB: WDR74

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR74 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR74 gene:
    Search GeneIP for patents involving WDR74

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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