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WDR73 Gene

protein-coding   GIFtS: 43
GCID: GC15M085185

WD Repeat Domain 73

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 731 2
FLJ00296 Protein2
WD Repeat-Containing Protein 732

External Ids:    HGNC: 259281   Entrez Gene: 849422   Ensembl: ENSG000001770827   UniProtKB: Q6P4I23   

Export aliases for WDR73 gene to outside databases

Previous GC identifers: GC15M082988 GC15M061271


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR73 Gene:
WDR73 (WD repeat domain 73) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the WDR73 gene promoter:
         GR   NF-AT   HOXA5   FOXO4   ARP-1   NF-AT3   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR73 promoter sequence
   Search Chromatin IP Primers for WDR73

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

WDR73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR73 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085185:  view genomic region     (about GC identifiers)

Start:
85,185,999 bp from pter      End:
85,197,574 bp from pter
Size:
11,576 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2 (See protein sequence)
Recommended Name: WD repeat-containing protein 73  
Size: 378 amino acids; 41685 Da
Sequence caution: Sequence=AAF28942.1; Type=Frameshift; Positions=374;
Secondary accessions: Q96JZ1 Q9P0B7

Explore the universe of human proteins at neXtProt for WDR73: NX_Q6P4I2

Explore proteomics data for WDR73 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR73 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116245.2  
    ENSEMBL proteins: 
     ENSP00000387982   ENSP00000453779   ENSP00000453732   ENSP00000453204  

    WDR73 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WDR73

     
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    antibodies-online proteins for WDR73 (5 products) 

     
    antibodies-online peptides for WDR73

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    antibodies-online antibodies for WDR73 (13 products) 

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    Cloud-Clone Corp. CLIAs for WDR73
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    antibodies-online kits for WDR73 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6P4I2

    ProtoNet protein and cluster: Q6P4I2

    UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2
    Similarity: Belongs to the WD repeat WDR73 family
    Similarity: Contains 3 WD repeats


    Find genes that share domains with WDR73           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR73           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDR73

    miRNA
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    miRTarBase miRNAs that target WDR73:
    hsa-mir-98-5p (MIRT027597)

    Block miRNA regulation of human, mouse, rat WDR73 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WDR73:
    hsa-miR-1207-3p hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidWDR73 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WDR73
    Predesigned siRNA for gene silencing in human, mouse, rat WDR73

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: WDR73 (NM_032856)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR73
    Interactions:

        Search GeneGlobe Interaction Network for WDR73

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for WDR73 (Q6P4I22, 3 ENSP000003879824) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271685 I2D: score=2 
    SMN2Q166372, 3MINT-8271685 I2D: score=2 
    ANXA7P200732, 3MINT-8248959 I2D: score=2 
    CDKN1AP389362, 3MINT-8252450 I2D: score=2 
    DAZAP2Q150382, 3MINT-8254067 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR73



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR73 gene: 
    NM_032856.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000559994(uc002bkv.2) ENST00000434634(uc002bkw.2) ENST00000398528(uc002bkx.2)
    ENST00000559015 ENST00000559126 ENST00000558608 ENST00000560966(uc010upa.1)
    ENST00000559224 ENST00000558521 ENST00000559452 ENST00000561329 ENST00000559178
    ENST00000560835 ENST00000560088 ENST00000561447 ENST00000560252 ENST00000558019
    ENST00000560182
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR73 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate WDR73:
    hsa-miR-1207-3p hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidWDR73 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WDR73
    Predesigned siRNA for gene silencing in human, mouse, rat WDR73
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    GenScript: all cDNA clones in your preferred vector: WDR73 (NM_032856)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR73
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR73
      QuantiTect SYBR Green Assays in human, mouse, rat WDR73
      QuantiFast Probe-based Assays in human, mouse, rat WDR73

    Selected AceView cDNA sequences (see all 201):

    AA450270 AA461318 BU839091 BX361715 AL702494 BU172343 BQ941366 AI277211 
    CD242585 BM799415 CR598576 AK090406 AI377556 BU174360 BC050648 CN481562 
    CA313856 CR609211 BQ679334 AI352162 AI377505 AI377567 BC014115 AA887835 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR73 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                      -     -     -     -           -                       -     -     -           -     -                 -     -     -   
    SP2:                                            -     -     -           -                       -     -     -           -     -                 -     -     -   
    SP3:                                      -     -     -     -           -                       -     -     -           -     -                 -               
    SP4:                                            -     -     -           -                       -     -     -           -     -                 -               
    SP5:                                      -     -     -     -           -                                               -     -                 -     -     -   

    ExUns: 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for WDR73

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR73 Expression
    About this image

    WDR73 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR73 Protein Expression
        Custom PCR Arrays for WDR73
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for WDR73 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr731 , 5 WD repeat domain 731, 5 82.07(n)1
    79.73(a)1
      7 (45.71 cM)5
    719681  NM_028026.21  NP_082302.21 
     808907235 
    chicken
    (Gallus gallus)
    Aves WDR731 WD repeat domain 73 58.98(n)
    50.17(a)
      425698  XM_423425.4  XP_423425.4 
    lizard
    (Anolis carolinensis)
    Reptilia WDR736
    WD repeat domain 73
    43(a)
    1 ↔ 1
    GL343899.1(126514-151438)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr731 WD repeat domain 73 53.58(n)
    41.58(a)
      496983  XM_002942416.2  XP_002942462.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr731 WD repeat domain 73 49.4(n)
    41.87(a)
      550339  NM_001017646.1  NP_001017646.1 


    ENSEMBL Gene Tree for WDR73 (if available)
    TreeFam Gene Tree for WDR73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR73 gene
    1 SIMAP similar gene for WDR73 using alignment to 7 protein entries:     WDR73_HUMAN (see all proteins):
    FLJ00296

    Find genes that share paralogs with WDR73           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR73 (see all 273)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426398481,2
    C--85186236(+) AAAGTA/GCACCT 1 -- ut310--------
    rs1113945581,2
    F--85186355(+) TTCTTC/G/TAAAAA 2 -- ut311CSA 1
    rs1807436821,2
    --85186504(+) ACCTTC/TGCAAT 1 -- ut310--------
    rs1147356781,2
    C,F--85186529(+) GTTCTT/AACTAT 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs72371,2
    C,F,H--85186577(+) GCTGGC/TAGACT 1 -- ut3130Minor allele frequency- T:0.17MN NA NS EA WA CSA 2990
    rs5108751,2
    C,F,A,H--85186637(-) GTGCTG/CATGTA 1 -- ut3134Minor allele frequency- C:0.34MN EA NA NS WA CSA 3172
    rs2010239941,2
    C--85186710(+) CGGGGG/TGCACA 2 A syn11Minor allele frequency- T:0.00EU 569
    rs1855383751,2
    C--85186712(+) GGGGGA/CACAAA 2 A S mis10--------
    rs2002949051,2
    --85186800(+) GTGTGA/GGTGGT 2 T syn10--------
    rs1996760761,2
    C--85186827(+) TCCATA/CCCATT 2 G syn10--------

    HapMap Linkage Disequilibrium report for WDR73 (85185999 - 85197574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR73:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672879CNV Deletion23128226
    nsv515983CNV Loss19592680
    nsv428310CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR73
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR73 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with WDR73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Genome-wide association study of chronic periodontitis in a general German population. (PubMed id 24024966)1 Teumer A....Kocher T. (J. Clin. Periodontol. 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84942 HGNC: 25928 AceView: FLJ14888 Ensembl:ENSG00000177082 euGenes: HUgn84942
    ECgene: WDR73 H-InvDB: WDR73

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR73 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR73 gene:
    Search GeneIP for patents involving WDR73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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