WDR73 Gene
protein-coding GIFtS: 43
GCID: GC15M085185
|
|
WD repeat domain 73
| |
Aliases
for WDR73 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 731 2 | | FLJ148881 | | HSPC2641 | | FLJ00296 Protein2 | | WD Repeat-Containing Protein 732 |
Export aliases for WDR73 gene to outside databasesPrevious GC identifers: GC15M082988 GC15M061271 |
Summaries
for WDR73 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR73 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR73 gene promoter:
GR NF-AT HOXA5 FOXO4 ARP-1 NF-AT3 GR-alpha NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR73
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR73 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2WDR73 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M085185: view genomic region
(about GC identifiers)
Start:
|
85,185,999 bp from pter |
End:
|
85,197,574 bp from pter |
Size:
|
11,576 bases |
Orientation:
|
minus strand |
|
Proteins
for WDR73 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2 (See
protein sequence)Recommended Name: WD repeat-containing protein 73 Size: 378 amino acids; 41685 Da
Sequence caution: Sequence=AAF28942.1; Type=Frameshift; Positions=374;
Secondary accessions: Q96JZ1 Q9P0B7Explore the universe of human proteins at neXtProt for WDR73: NX_Q6P4I2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P4I2
WDR73 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116245.2
ENSEMBL proteins: ENSP00000387982 ENSP00000453779 ENSP00000453732 ENSP00000453204
Human Recombinant Protein Products:
WDR73 Antibody Products:
Assay Products for WDR73: |
Protein
Domains /
Families
for WDR73 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR73 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6P4I2ProtoNet protein and cluster: Q6P4I2 UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2Similarity: Belongs to the WD repeat WDR73 familySimilarity: Contains 3 WD repeats |
Function
for WDR73 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR73 (NM_032856) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR73 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73 |
|
Pathways & Interactions
for WDR73 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR73
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/9 Interacting proteins for WDR73 (Q6P4I22, 3 ENSP000003879824) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for WDR73 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR73
Search CenterWatch for drugs/clinical trials and news about WDR73
|
Transcripts
for WDR73 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR73 gene: NM_032856.2 Unigene Cluster for WDR73: WD repeat domain 73 Hs.165736 [show with all ESTs]Unigene Representative Sequence: AK09040618/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000559994(uc002bkv.2) ENST00000434634(uc002bkw.2) ENST00000398528(uc002bkx.2)
ENST00000559015 ENST00000559126 ENST00000558608 ENST00000560966(uc010upa.1)
ENST00000559224 ENST00000558521 ENST00000559452 ENST00000561329 ENST00000559178
ENST00000560835 ENST00000560088 ENST00000561447 ENST00000560252 ENST00000558019
ENST00000560182
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR73 (NM_032856) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR73 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73 |
Additional cDNA sequence: AF161382.1 AK027200.1 AK027794.1 AK055578.1 AK055729.1 AK090406.1 AK090951.1 AK225068.1 AK225199.1 AK295372.1 BC014115.2 BC020252.2 BC050648.1 BC063392.1 20 DOTS entries: DT.114622 DT.100812587 DT.100029621 DT.100029617 DT.100812579 DT.95155565 DT.95113007 DT.95281432 DT.100812581 DT.121025549 DT.121025605 DT.95096836 DT.97819614 DT.121025613 DT.121025584 DT.97844546 DT.121025565 DT.121025610 DT.95285668 DT.92428018 24/201 AceView cDNA sequences (see all 201): BQ679334 CN481562 BC014115 AI377567 BP357444 BX361715 BQ681146 CR609211 AI089550 BQ941366 AK090406 BU161060 CB123981 AA450270 AI377505 BU839091 CR598576 AL702494 AA887835 BU784628 AI277211 AI377556 CA395221 BU174360
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for WDR73 (see all 18) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | - | | - | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | - | | - | | - | | | | - | | | | | | | | - | | - | | - | | | | - | | - | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | - | | - | | | | | | - | | - | | - | |
| ExUns: | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR73
|
Expression
for WDR73 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR73 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WDR73 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR73
SOURCE GeneReport for Unigene cluster: Hs.165736
SABiosciences Custom PCR Arrays for WDR73
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR73
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR73 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR73 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR73 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73 |
Orthologs
for WDR73 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for WDR73 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for WDR73 (if available)
TreeFam Gene Tree for WDR73 (if available) |
Paralogs
for WDR73 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR73 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR73 (85185999 - 85197574 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR73
1 CNV: 49602 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR73 |
|
Disorders
/ Diseases
for WDR73 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR73 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR73 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR73) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)2 Zhang Q.-H.... Chen Z. (2000)
|
External Searches for WDR73 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR73 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR73 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR73 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR73 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR73 gene:
Search GeneIP for patents involving WDR73
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR73 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR73 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR73 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR73 | | | OriGene Protein Over-expression Lysate for WDR73 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR73 | | OriGene 3'-UTR Clone for WDR73 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR73 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WDR73 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR73 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR73 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR73 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR73 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR73 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR73 |
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| |  |  |  |  | | | | |
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 | | | WDR73 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73 |
|  |  |  | | | | ThermoFisher Antibody for WDR73 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73 |
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