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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR73 Gene

protein-coding   GIFtS: 45
GCID: GC15M085185

WD Repeat Domain 73

  Search for WDR73
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 731 2
FLJ00296 Protein2
WD Repeat-Containing Protein 732

External Ids:    HGNC: 259281   Entrez Gene: 849422   Ensembl: ENSG000001770827   UniProtKB: Q6P4I23   

Export aliases for WDR73 gene to outside databases

Previous GC identifers: GC15M082988 GC15M061271


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR73 Gene: 
WDR73 (WD repeat domain 73) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR73 gene promoter:
         GR   NF-AT   HOXA5   FOXO4   ARP-1   NF-AT3   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR73 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

WDR73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR73 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M085185:  view genomic region     (about GC identifiers)

Start:
85,185,999 bp from pter      End:
85,197,574 bp from pter
Size:
11,576 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2 (See protein sequence)
Recommended Name: WD repeat-containing protein 73  
Size: 378 amino acids; 41685 Da
Sequence caution: Sequence=AAF28942.1; Type=Frameshift; Positions=374;
Secondary accessions: Q96JZ1 Q9P0B7

Explore the universe of human proteins at neXtProt for WDR73: NX_Q6P4I2

Explore proteomics data for WDR73 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P4I2

  • WDR73 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR73 Protein Expression
    REFSEQ proteins: NP_116245.2  
    ENSEMBL proteins: 
     ENSP00000387982   ENSP00000453779   ENSP00000453732   ENSP00000453204  

    Human Recombinant Protein Products for WDR73: 
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    Cloud-Clone Corp. Proteins for WDR73 


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    Cloud-Clone Corp. ELISAs for WDR73 
    Cloud-Clone Corp. CLIAs for WDR73


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6P4I2

    ProtoNet protein and cluster: Q6P4I2

    UniProtKB/Swiss-Prot: WDR73_HUMAN, Q6P4I2
    Similarity: Belongs to the WD repeat WDR73 family
    Similarity: Contains 3 WD repeats


    WDR73 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR73 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR73 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WDR73

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR73 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR73 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR73:
    hsa-miR-1207-3p hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidWDR73 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR73

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/9 Interacting proteins for WDR73 (Q6P4I22, 3 ENSP000003879824) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271685 I2D: score=2 
    SMN2Q166372, 3MINT-8271685 I2D: score=2 
    ANXA7P200732, 3MINT-8248959 I2D: score=2 
    CDKN1AP389362, 3MINT-8252450 I2D: score=2 
    DAZAP2Q150382, 3MINT-8254067 I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR73

    Search CenterWatch for drugs/clinical trials and news about WDR73

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR73 gene: 
    NM_032856.2  

    Unigene Cluster for WDR73:

    WD repeat domain 73
    Hs.745027  [show with all ESTs]
    Unigene Representative Sequence: AK090406
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000559994(uc002bkv.2) ENST00000434634(uc002bkw.2) ENST00000398528(uc002bkx.2)
    ENST00000559015 ENST00000559126 ENST00000558608 ENST00000560966(uc010upa.1)
    ENST00000559224 ENST00000558521 ENST00000559452 ENST00000561329 ENST00000559178
    ENST00000560835 ENST00000560088 ENST00000561447 ENST00000560252 ENST00000558019
    ENST00000560182
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR73:
    hsa-miR-1207-3p hsa-miR-4268
    SwitchGear 3'UTR luciferase reporter plasmidWDR73 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WDR73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR73
    Clone
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    OriGene clones in human, mouse for WDR73 (see all 9)
    OriGene ORF clones in mouse, rat for WDR73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR73 (NM_032856)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR73
    Sirion Biotech Customized lentivirus for stable overexpression of WDR73 
                         Customized lentivirus expression plasmids for stable overexpression of WDR73 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR73
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR73

    Additional mRNA sequence: 

    AF161382.1 AK027200.1 AK027794.1 AK055578.1 AK055729.1 AK090406.1 AK090951.1 AK225068.1 
    AK225199.1 AK295372.1 BC014115.2 BC020252.2 BC050648.1 BC063392.1 

    20 DOTS entries:

    DT.114622  DT.100812587  DT.100029621  DT.100029617  DT.100812579  DT.95155565  DT.95113007  DT.95281432 
    DT.100812581  DT.121025549  DT.121025605  DT.95096836  DT.97819614  DT.121025613  DT.121025584  DT.97844546 
    DT.121025565  DT.121025610  DT.95285668  DT.92428018 

    24/201 AceView cDNA sequences (see all 201):

    AI377567 AK090406 BQ941366 CA313856 BM799415 AA887835 BC014115 BC050648 
    AI089550 CR609211 AI377556 AI377505 BQ681146 CD242585 BQ679334 BU172343 
    CN481562 AA450270 AI352162 BU174360 CA395221 AL702494 BP357444 BU839091 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for WDR73 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                      -     -     -     -           -                       -     -     -           -     -                 -     -     -   
    SP2:                                            -     -     -           -                       -     -     -           -     -                 -     -     -   
    SP3:                                      -     -     -     -           -                       -     -     -           -     -                 -               
    SP4:                                            -     -     -           -                       -     -     -           -     -                 -               
    SP5:                                      -     -     -     -           -                                               -     -                 -     -     -   

    ExUns: 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for WDR73

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR73 Expression
    About this image


    See WDR73 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR73

    SOURCE GeneReport for Unigene cluster: Hs.745027
        SABiosciences Custom PCR Arrays for WDR73
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WDR73 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr731 , 5 WD repeat domain 731, 5 82.07(n)1
    79.73(a)1
      7 (45.71 cM)5
    719681  NM_028026.21  NP_082302.21 
     808907235 
    chicken
    (Gallus gallus)
    Aves WDR731 WD repeat domain 73 59.04(n)
    50.51(a)
      425698  XM_423425.3  XP_423425.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR736
    WD repeat domain 73
    43(a)
    1 ↔ 1
    GL343899.1(126514-151438)
    zebrafish
    (Danio rerio)
    Actinopterygii wdr731 WD repeat domain 73 49.68(n)
    42.42(a)
      550339  NM_001017646.1  NP_001017646.1 


    ENSEMBL Gene Tree for WDR73 (if available)
    TreeFam Gene Tree for WDR73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR73 gene
    1 SIMAP similar gene for WDR73 using alignment to 7 protein entries:     WDR73_HUMAN (see all proteins):
    FLJ00296

    WDR73 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/273 SNPs in WDR73 are shown (see all 273)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426398481,2
    C--85186236(+) AAAGTA/GCACCT 1 -- ut310--------
    rs1113945581,2
    F--85186355(+) TTCTTC/G/TAAAAA 2 -- ut311CSA 1
    rs1807436821,2
    --85186504(+) ACCTTC/TGCAAT 1 -- ut310--------
    rs1147356781,2
    C,F--85186529(+) GTTCTT/AACTAT 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs72371,2
    C,F,H--85186577(+) GCTGGC/TAGACT 1 -- ut3130Minor allele frequency- T:0.17MN NA NS EA WA CSA 2990
    rs5108751,2
    C,F,A,H--85186637(-) GTGCTG/CATGTA 1 -- ut3134Minor allele frequency- C:0.34MN EA NA NS WA CSA 3172
    rs2010239941,2
    C--85186710(+) CGGGGG/TGCACA 2 A syn11Minor allele frequency- T:0.00EU 569
    rs1855383751,2
    C--85186712(+) GGGGGA/CACAAA 2 A S mis10--------
    rs2002949051,2
    --85186800(+) GTGTGA/GGTGGT 2 T syn10--------
    rs1996760761,2
    C--85186827(+) TCCATA/CCCATT 2 G syn10--------

    HapMap Linkage Disequilibrium report for WDR73 (85185999 - 85197574 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR73:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672879CNV Deletion23128226
    nsv515983CNV Loss19592680
    nsv428310CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR73
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR73 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)2 Zhang Q.-H.... Chen Z. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84942 HGNC: 25928 AceView: FLJ14888 Ensembl:ENSG00000177082 euGenes: HUgn84942
    ECgene: WDR73 H-InvDB: WDR73

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR73 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR73 gene:
    Search GeneIP for patents involving WDR73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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