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Aliases for WDR73 Gene

Aliases for WDR73 Gene

  • WD Repeat Domain 73 2 3
  • WD Repeat-Containing Protein 73 3
  • FLJ00296 Protein 3
  • HSPC264 3
  • GAMOS 3

External Ids for WDR73 Gene

Summaries for WDR73 Gene

Entrez Gene Summary for WDR73 Gene

  • The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for WDR73 Gene

WDR73 (WD Repeat Domain 73) is a Protein Coding gene. Diseases associated with WDR73 include galloway-mowat syndrome.

UniProtKB/Swiss-Prot for WDR73 Gene

  • May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR73 Gene

Genomics for WDR73 Gene

Genomic Location for WDR73 Gene

Start:
84,639,281 bp from pter
End:
84,654,343 bp from pter
Size:
15,063 bases
Orientation:
Minus strand

Genomic View for WDR73 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR73 Gene

Regulatory Elements for WDR73 Gene

Proteins for WDR73 Gene

  • Protein details for WDR73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4I2-WDR73_HUMAN
    Recommended name:
    WD repeat-containing protein 73
    Protein Accession:
    Q6P4I2
    Secondary Accessions:
    • Q96JZ1
    • Q9P0B7

    Protein attributes for WDR73 Gene

    Size:
    378 amino acids
    Molecular mass:
    41685 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28942.1; Type=Frameshift; Positions=374; Evidence={ECO:0000305};

neXtProt entry for WDR73 Gene

Proteomics data for WDR73 Gene at MOPED

Post-translational modifications for WDR73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR73 Gene

No data available for DME Specific Peptides for WDR73 Gene

Domains for WDR73 Gene

Gene Families for WDR73 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR73 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P4I2

UniProtKB/Swiss-Prot:

WDR73_HUMAN
Family:
  • Belongs to the WD repeat WDR73 family.:
    • Q6P4I2
Similarity:
  • Contains 6 WD repeats.:
    • Q6P4I2
genes like me logo Genes that share domains with WDR73: view

Function for WDR73 Gene

Molecular function for WDR73 Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283).

Gene Ontology (GO) - Molecular Function for WDR73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR73: view

miRNA for WDR73 Gene

miRTarBase miRNAs that target WDR73

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR73 Gene

Localization for WDR73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR73 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow. {ECO:0000269 PubMed:25466283}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR73 Gene COMPARTMENTS Subcellular localization image for WDR73 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005829 cytosol IEA --
GO:0032154 cleavage furrow IEA --
genes like me logo Genes that share ontologies with WDR73: view

Pathways for WDR73 Gene

SuperPathways for WDR73 Gene

No Data Available

Interacting Proteins for WDR73 Gene

Gene Ontology (GO) - Biological Process for WDR73 Gene

None

No data available for Pathways by source for WDR73 Gene

Transcripts for WDR73 Gene

Unigene Clusters for WDR73 Gene

WD repeat domain 73:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR73 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - -
SP14: - - - -
SP15: - - -
SP16: - -
SP17:
SP18: - -

ExUns: 12a · 12b ^ 13a · 13b · 13c · 13d · 13e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for WDR73 Gene

GeneLoc Exon Structure for
WDR73
ECgene alternative splicing isoforms for
WDR73

Expression for WDR73 Gene

mRNA expression in normal human tissues for WDR73 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR73 Gene

SOURCE GeneReport for Unigene cluster for WDR73 Gene Hs.745027

mRNA Expression by UniProt/SwissProt for WDR73 Gene

Q6P4I2-WDR73_HUMAN
Tissue specificity: Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cerebellar nuclei and in pyramidal neurons of the cerebral cortex (at protein level). In the white matter, mainly present in astrocytes, but not in oligodendrocytes (at protein level). Also highly expressed in endothelial cells of cerebral capillaries (at protein level).
genes like me logo Genes that share expressions with WDR73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR73 Gene

Orthologs for WDR73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for WDR73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR73 35
  • 99.47 (n)
  • 99.74 (a)
WDR73 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR73 35
  • 87.18 (n)
  • 85.47 (a)
WDR73 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR73 35
  • 86.22 (n)
  • 81.89 (a)
WDR73 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr73 35
  • 82.07 (n)
  • 79.73 (a)
Wdr73 16
Wdr73 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR73 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR73 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr73 35
  • 81.53 (n)
  • 79.73 (a)
chicken
(Gallus gallus)
Aves WDR73 35
  • 58.98 (n)
  • 50.17 (a)
WDR73 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR73 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr73 35
  • 53.58 (n)
  • 41.58 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr73 35
  • 49.4 (n)
  • 41.87 (a)
wdr73 36
  • 40 (a)
OneToOne
Species with no ortholog for WDR73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR73 Gene

ENSEMBL:
Gene Tree for WDR73 (if available)
TreeFam:
Gene Tree for WDR73 (if available)

Paralogs for WDR73 Gene

Selected SIMAP similar genes for WDR73 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with WDR73: view

No data available for Paralogs for WDR73 Gene

Variants for WDR73 Gene

Sequence variations from dbSNP and Humsavar for WDR73 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7237 -- 84,643,346(+) GCTGG(C/T)AGACT utr-variant-3-prime, nc-transcript-variant
rs9595 -- 84,647,344(-) GGGGC(A/T)GTGGC intron-variant
rs309429 -- 84,650,434(-) gcagt(A/G)agcca intron-variant
rs510875 -- 84,643,406(-) GTGCT(C/G)ATGTA utr-variant-3-prime, nc-transcript-variant
rs1141368 -- 84,645,019(-) gagct(A/G)agatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR73 Gene

Variant ID Type Subtype PubMed ID
nsv428310 CNV Gain+Loss 18775914
esv2672879 CNV Deletion 23128226
nsv515983 CNV Loss 19592680

Relevant External Links for WDR73 Gene

HapMap Linkage Disequilibrium report
WDR73
Human Gene Mutation Database (HGMD)
WDR73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR73 Gene

Disorders for WDR73 Gene

UniProtKB/Swiss-Prot

WDR73_HUMAN
  • Galloway-Mowat syndrome (GAMOS) [MIM:251300]: A rare, autosomal recessive disease with onset in infancy, and characterized by microcephaly, central nervous system abnormalities resulting in severe neurological impairment and intellectual disability, and nephrotic syndrome. Most patients develop seizures and nephrotic syndrome late in childhood. Note=The disease is caused by mutations affecting the gene represented in this entry. {ECO:0000269 PubMed:25466283}.

(1) MalaCards Diseases for WDR73 Gene

Search for WDR73 Gene in MalaCards »
genes like me logo Genes that share disorders with WDR73: view

Publications for WDR73 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Loss-of-function mutations in WDR73 are responsible for microcephaly and steroid-resistant nephrotic syndrome: Galloway-Mowat syndrome. (PMID: 25466283) Colin E. … Antignac C. (Am. J. Hum. Genet. 2014) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for WDR73 Gene

Sources for WDR73 Gene

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