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Aliases for WDR70 Gene

Aliases for WDR70 Gene

  • WD Repeat Domain 70 2 3 5

External Ids for WDR70 Gene

Previous GeneCards Identifiers for WDR70 Gene

  • GC05P037416
  • GC05P037331

Summaries for WDR70 Gene

GeneCards Summary for WDR70 Gene

WDR70 (WD Repeat Domain 70) is a Protein Coding gene. GO annotations related to this gene include enzyme binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR70 Gene

Genomics for WDR70 Gene

Regulatory Elements for WDR70 Gene

Enhancers for WDR70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G036873 2.4 ENCODE dbSUPER 25.1 -502.2 -502247 6.4 CREB3L1 AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 GLIS1 NBN WDR70 C5orf42 OFD1P17 ENSG00000250155 NIPBL KRT18P31
GH05G036688 2 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -689.2 -689211 2.4 PKNOX1 WRNIP1 SIN3A ZNF2 ZNF143 ZNF416 ZNF207 ZNF263 SP3 ZHX2 ENSG00000250155 WDR70 SLC1A3 RANBP3L NIPBL ENSG00000279400 GC05P036714
GH05G036656 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.7 -721.3 -721264 2.9 TBP BRCA1 RAD21 RFX5 YY1 SMARCC2 RCOR1 FOS DEK ZHX1 C5orf42 WDR70 SLC1A3 NIPBL ENSG00000279400 ENSG00000274441
GH05G036605 1.3 ENCODE dbSUPER 16.4 -772.0 -771971 2.8 PKNOX1 FEZF1 GLI4 BRCA1 ZNF2 GATA2 KLF7 FOS ZNF263 SP3 WDR70 OFD1P17 SLC1A3 ENSG00000274441
GH05G037737 1.5 Ensembl ENCODE dbSUPER 10.4 +360.5 360452 4.6 PKNOX1 SIN3A FEZF1 FOS JUNB TSHZ1 ZNF623 TBX21 MYNN NBN C5orf42 GDNF-AS1 GDNF WDR70 RNU6-484P GC05M037700
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR70 on UCSC Golden Path with GeneCards custom track

Promoters for WDR70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179620 289 1400 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1

Genomic Location for WDR70 Gene

Chromosome:
5
Start:
37,379,212 bp from pter
End:
37,753,435 bp from pter
Size:
374,224 bases
Orientation:
Plus strand

Genomic View for WDR70 Gene

Genes around WDR70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR70 Gene

Proteins for WDR70 Gene

  • Protein details for WDR70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW82-WDR70_HUMAN
    Recommended name:
    WD repeat-containing protein 70
    Protein Accession:
    Q9NW82
    Secondary Accessions:
    • Q9H053

    Protein attributes for WDR70 Gene

    Size:
    654 amino acids
    Molecular mass:
    73201 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAC21644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR70 Gene

Post-translational modifications for WDR70 Gene

  • Ubiquitination at Lys296
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR70 Gene

No data available for DME Specific Peptides for WDR70 Gene

Domains & Families for WDR70 Gene

Gene Families for WDR70 Gene

Suggested Antigen Peptide Sequences for WDR70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW82

UniProtKB/Swiss-Prot:

WDR70_HUMAN :
  • Belongs to the WD repeat GAD-1 family.
Family:
  • Belongs to the WD repeat GAD-1 family.
genes like me logo Genes that share domains with WDR70: view

Function for WDR70 Gene

Gene Ontology (GO) - Molecular Function for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with WDR70: view
genes like me logo Genes that share phenotypes with WDR70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR70 Gene

Localization for WDR70 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR70 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR70 Gene

Pathways & Interactions for WDR70 Gene

SuperPathways for WDR70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR70 Gene

Drugs & Compounds for WDR70 Gene

No Compound Related Data Available

Transcripts for WDR70 Gene

Unigene Clusters for WDR70 Gene

WD repeat domain 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR70 Gene

No ASD Table

Relevant External Links for WDR70 Gene

GeneLoc Exon Structure for
WDR70
ECgene alternative splicing isoforms for
WDR70

Expression for WDR70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR70 Gene

Protein differential expression in normal tissues from HIPED for WDR70 Gene

This gene is overexpressed in Esophagus (36.9) and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR70 Gene



Protein tissue co-expression partners for WDR70 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR70 Gene:

WDR70

SOURCE GeneReport for Unigene cluster for WDR70 Gene:

Hs.213690

Evidence on tissue expression from TISSUES for WDR70 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with WDR70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR70 Gene

Orthologs for WDR70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR70 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia WDR70 35
  • 95 (a)
OneToOne
LOC489225 34
  • 93.87 (n)
cow
(Bos Taurus)
Mammalia WDR70 34 35
  • 91.72 (n)
rat
(Rattus norvegicus)
Mammalia Wdr70 34
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Wdr70 34 16 35
  • 88.02 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR70 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR70 34 35
  • 74.03 (n)
lizard
(Anolis carolinensis)
Reptilia WDR70 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr70 34
  • 73.56 (n)
Str.7113 34
zebrafish
(Danio rerio)
Actinopterygii WDR70 (1 of 2) 35
  • 75 (a)
OneToMany
LOC101884837 34
  • 69.49 (n)
WDR70 (2 of 2) 35
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5543 34 35
  • 55.56 (n)
worm
(Caenorhabditis elegans)
Secernentea gad-1 34 35
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20330 34
  • 52.16 (n)
rice
(Oryza sativa)
Liliopsida Os10g0464100 34
  • 50.51 (n)
Os.12790 34
corn
(Zea mays)
Liliopsida Zm.12874 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11370 34
Species where no ortholog for WDR70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR70 Gene

ENSEMBL:
Gene Tree for WDR70 (if available)
TreeFam:
Gene Tree for WDR70 (if available)

Paralogs for WDR70 Gene

Pseudogenes.org Pseudogenes for WDR70 Gene

genes like me logo Genes that share paralogs with WDR70: view

No data available for Paralogs for WDR70 Gene

Variants for WDR70 Gene

Sequence variations from dbSNP and Humsavar for WDR70 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000003126 -- 37,451,735(+) TCACG(A/G)CTGTA intron-variant
rs1000003541 -- 37,480,024(+) AATTC(A/G)GCACA intron-variant
rs1000019951 -- 37,694,696(+) TGTTG(C/G)GGGGT intron-variant
rs1000025834 -- 37,592,388(+) TCACT(C/G)ATAAG intron-variant
rs1000026556 -- 37,741,714(+) CATGG(A/G)CCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR70 Gene

Variant ID Type Subtype PubMed ID
dgv5634n100 CNV gain 25217958
dgv9722n54 CNV loss 21841781
dgv9727n54 CNV gain 21841781
esv2591687 CNV deletion 19546169
esv2661091 CNV deletion 23128226
esv2665634 CNV deletion 23128226
esv2677567 CNV deletion 23128226
esv2730085 CNV deletion 23290073
esv2730086 CNV deletion 23290073
esv2730087 CNV deletion 23290073
esv2730088 CNV deletion 23290073
esv28527 CNV loss 19812545
esv3302655 CNV tandem duplication 20981092
esv3303363 CNV mobile element insertion 20981092
esv3306061 CNV mobile element insertion 20981092
esv3327450 CNV insertion 20981092
esv3356247 CNV duplication 20981092
esv3370577 CNV insertion 20981092
esv3436232 CNV insertion 20981092
esv3436852 CNV insertion 20981092
esv3565823 CNV deletion 23714750
esv3570076 CNV loss 25503493
esv3575837 CNV gain 25503493
esv3575838 CNV gain 25503493
esv3604728 CNV gain 21293372
esv3604736 CNV loss 21293372
esv3604737 CNV loss 21293372
esv3604738 CNV gain 21293372
esv3604739 CNV loss 21293372
esv3604740 CNV loss 21293372
esv3604741 CNV gain 21293372
esv3604743 CNV gain 21293372
esv3604744 CNV loss 21293372
esv3604746 CNV loss 21293372
esv3604748 CNV gain 21293372
esv3604749 CNV loss 21293372
esv3894176 CNV loss 25118596
nsv1015514 CNV loss 25217958
nsv1018722 CNV loss 25217958
nsv1028838 CNV gain 25217958
nsv1030223 CNV loss 25217958
nsv1030797 CNV gain 25217958
nsv1033104 CNV loss 25217958
nsv1116545 OTHER inversion 24896259
nsv1129257 CNV insertion 24896259
nsv1133357 CNV tandem duplication 24896259
nsv1140532 CNV deletion 24896259
nsv1140533 CNV deletion 24896259
nsv1143132 CNV tandem duplication 24896259
nsv1151613 CNV insertion 26484159
nsv329607 CNV deletion 16902084
nsv471012 CNV gain 18288195
nsv474927 CNV novel sequence insertion 20440878
nsv476907 CNV novel sequence insertion 20440878
nsv477893 CNV novel sequence insertion 20440878
nsv597823 CNV gain 21841781
nsv597844 CNV gain 21841781
nsv597845 CNV gain 21841781
nsv597846 CNV gain 21841781
nsv819667 CNV loss 19587683
nsv950669 CNV deletion 24416366
nsv968168 CNV duplication 23825009
nsv968302 CNV duplication 23825009
nsv968905 CNV duplication 23825009
nsv980638 CNV duplication 23825009

Variation tolerance for WDR70 Gene

Residual Variation Intolerance Score: 9.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR70 Gene

Disorders for WDR70 Gene

Relevant External Links for WDR70

Genetic Association Database (GAD)
WDR70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR70

No disorders were found for WDR70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR70 Gene

Publications for WDR70 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent resection. (PMID: 27098497) Zeng M. … Liu C. (Nat Commun 2016) 3 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64

Products for WDR70 Gene

Sources for WDR70 Gene

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