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WDR70 Gene

protein-coding   GIFtS: 43
GCID: GC05P037380

WD Repeat Domain 70

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 701 2
WD Repeat-Containing Protein 702

External Ids:    HGNC: 254951   Entrez Gene: 551002   Ensembl: ENSG000000820687   UniProtKB: Q9NW823   

Export aliases for WDR70 gene to outside databases

Previous GC identifers: GC05P037416 GC05P037331


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR70 Gene:
WDR70 (WD repeat domain 70) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR70 gene promoter:
         GR   C/EBPbeta   MIF-1   NF-AT   NF-AT2   E2F-1   E2F   SEF-1 (1)   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR70 promoter sequence
   Search Chromatin IP Primers for WDR70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

WDR70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR70 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P037380:  view genomic region     (about GC identifiers)

Start:
37,379,314 bp from pter      End:
37,753,537 bp from pter
Size:
374,224 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR70_HUMAN, Q9NW82 (See protein sequence)
Recommended Name: WD repeat-containing protein 70  
Size: 654 amino acids; 73201 Da
Sequence caution: Sequence=CAC21644.1; Type=Erroneous initiation;
Secondary accessions: Q9H053

Explore the universe of human proteins at neXtProt for WDR70: NX_Q9NW82

Explore proteomics data for WDR70 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys296
  • Modification sites at PhosphoSitePlus

  • See WDR70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060504.1  
    ENSEMBL proteins: 
     ENSP00000265107   ENSP00000425841  

    WDR70 Human Recombinant Protein Products:

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    antibodies-online proteins for WDR70 (3 products) 

     
    antibodies-online peptides for WDR70

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    antibodies-online antibodies for WDR70 (3 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NW82

    ProtoNet protein and cluster: Q9NW82

    UniProtKB/Swiss-Prot: WDR70_HUMAN, Q9NW82
    Similarity: Belongs to the WD repeat GAD-1 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR70           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for WDR70:
     Decreased number of cells in m  Decreased viability of wild-ty  High actin ratio cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR70
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus2
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR70
    Interactions:

        Search GeneGlobe Interaction Network for WDR70

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for WDR70 (Q9NW823 ENSP000002651074) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WDR48Q8TAF33, ENSP000003074914I2D: score=2 STRING: ENSP00000307491
    CDC40ENSP000003043704STRING: ENSP00000304370
    PRPF19ENSP000002275244STRING: ENSP00000227524
    NR2E1ENSP000003579824STRING: ENSP00000357982
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR70



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR70 gene: 
    NM_018034.2  

    Unigene Cluster for WDR70:

    WD repeat domain 70
    Hs.213690  [show with all ESTs]
    Unigene Representative Sequence: BX537655
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265107(uc003jkv.3) ENST00000504564(uc010iva.1) ENST00000511906
    ENST00000505799 ENST00000510699 ENST00000507136 ENST00000508730
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR70
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    GenScript: all cDNA clones in your preferred vector: WDR70 (NM_018034)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR70
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat WDR70
      QuantiFast Probe-based Assays in human, mouse, rat WDR70

    Additional mRNA sequence: 

    AK001095.1 AK291179.1 AK310901.1 AL512685.1 BC009648.1 BC025315.1 BX537655.1 

    4 DOTS entries:

    DT.411849  DT.100025289  DT.100665911  DT.100747870 

    Selected AceView cDNA sequences (see all 103):

    NM_018034 BM979954 BM465577 AU120245 BC025315 AK001095 BQ649486 BU146540 
    BI258449 BQ654135 BM476705 AA179602 BQ647961 CN481774 AA582323 BC009648 
    BQ064814 CD244814 BX325272 CB045128 BE280787 CR597628 BQ059157 BG217249 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATTAAAAA
    WDR70 Expression
    About this image

    WDR70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.213690
        Custom PCR Arrays for WDR70
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR70 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr701 , 5 WD repeat domain 701, 5 88.02(n)1
    90.83(a)1
      15 (3.82 cM)5
    5450851  NM_001081402.11  NP_001074871.11 
     78730555 
    chicken
    (Gallus gallus)
    Aves WDR701 WD repeat domain 70 74.03(n)
    76.47(a)
      427444  NM_001195002.1  NP_001181931.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR706
    WD repeat domain 70
    75(a)
    1 ↔ 1
    GL343241.1(802081-927217)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054274.12   -- 86.96(n)    BC054274.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018848371 WD repeat-containing protein 70-like 69.49(n)
    70.9(a)
      101884837  XM_005172585.1  XP_005172642.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55431 CG5543 55.56(n)
    50.49(a)
      37768  NM_137988.2  NP_611832.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gad-11 gad-1   --   179027  NM_072234.4  NP_504635.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G203301 AT2G20330 52.16(n)
    43.7(a)
      816552  NM_127592.3  NP_179623.1 
    rice
    (Oryza sativa)
    Liliopsida Os.127902 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.67(n)    NM_196906.1 


    ENSEMBL Gene Tree for WDR70 (if available)
    TreeFam Gene Tree for WDR70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR70 gene

    Find genes that share paralogs with WDR70           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for WDR70
    PGOHUM00000237815 PGOHUM00000235340 PGOHUM00000235712


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR70 (see all 7446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510583921,2
    --37377422(+) ATCCTA/GGCACT 1 -- us2k10--------
    rs1400913861,2
    --37377442(+) TGAGGC/TGGGTG 1 -- us2k10--------
    rs1915457221,2
    C--37377518(+) AATACA/CAAAAT 1 -- us2k10--------
    rs1840018481,2
    --37377758(+) GAGATC/TGCGCC 1 -- us2k10--------
    rs1889415111,2
    --37377843(+) CACATA/GTAATC 1 -- us2k10--------
    rs1931486141,2
    --37377880(+) AGAATC/TGCTTG 1 -- us2k10--------
    rs597754011,2
    C,F--37378083(+) AGGCCA/TGGTGC 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs611548571,2
    C,F--37378156(+) GAGATG/TGAGAC 1 -- us2k13Minor allele frequency- T:0.25CSA 4
    rs1851840671,2
    --37378588(+) CGCCTA/GTAATC 1 -- us2k10--------
    rs1467985111,2
    --37378634(+) TGAACC/TTGGGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WDR70 (37379314 - 37629314 bp, first 250kb of WDR70)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WDR70 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730085CNV Deletion23290073
    esv2730086CNV Deletion23290073
    esv2730087CNV Deletion23290073
    esv2661091CNV Deletion23128226
    esv2591687CNV Deletion19546169
    esv2665634CNV Deletion23128226
    esv2677567CNV Deletion23128226
    esv2730088CNV Deletion23290073
    esv270338CNV Insertion20981092
    esv267643CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR70
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WDR70           About GenesLikeMe

    Genetic Association Database (GAD): WDR70

    Export disorders for WDR70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR70 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with WDR70)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55100 HGNC: 25495 AceView: FLJ10233 Ensembl:ENSG00000082068 euGenes: HUgn55100
    ECgene: WDR70 H-InvDB: WDR70

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR70 gene:
    Search GeneIP for patents involving WDR70

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WDR70  
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     Block miRNA regulation of human, mouse, rat WDR70 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WDR70
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     QuantiFast Probe-based Assays in human, mouse, rat WDR70 QuantiTect SYBR Green Assays in human, mouse, rat WDR70
     Custom PCR Arrays for WDR70 Search Chromatin IP Primers for WDR70
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     Search Tocris compounds for WDR70
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     Browse ESI BIO Cell Lines and PureStem Progenitors for WDR70
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR70
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     Search LSBio for Antibodies for WDR70
     Browse compounds at ApexBio
     Search Addgene for plasmids for WDR70
      Search eBioscience for proteins for WDR70
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      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
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