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Aliases for WDR70 Gene

Aliases for WDR70 Gene

  • WD Repeat Domain 70 2 3

External Ids for WDR70 Gene

Previous GeneCards Identifiers for WDR70 Gene

  • GC05P037416
  • GC05P037331

Summaries for WDR70 Gene

GeneCards Summary for WDR70 Gene

WDR70 (WD Repeat Domain 70) is a Protein Coding gene. GO annotations related to this gene include enzyme binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR70 Gene

Genomics for WDR70 Gene

Regulatory Elements for WDR70 Gene

Genomic Location for WDR70 Gene

37,379,212 bp from pter
37,753,435 bp from pter
374,224 bases
Plus strand

Genomic View for WDR70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for WDR70 Gene

Proteins for WDR70 Gene

  • Protein details for WDR70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 70
    Protein Accession:
    Secondary Accessions:
    • Q9H053

    Protein attributes for WDR70 Gene

    654 amino acids
    Molecular mass:
    73201 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAC21644.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR70 Gene

Proteomics data for WDR70 Gene at MOPED

Post-translational modifications for WDR70 Gene

  • Ubiquitination at Lys 296
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR70 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR70 Gene

Domains & Families for WDR70 Gene

Gene Families for WDR70 Gene

Protein Domains for WDR70 Gene

Suggested Antigen Peptide Sequences for WDR70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat GAD-1 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat GAD-1 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR70: view

Function for WDR70 Gene

Gene Ontology (GO) - Molecular Function for WDR70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with WDR70: view
genes like me logo Genes that share phenotypes with WDR70: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR70

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR70 Gene

Localization for WDR70 Gene

Subcellular locations from

Jensen Localization Image for WDR70 Gene COMPARTMENTS Subcellular localization image for WDR70 gene
Compartment Confidence
cytosol 2
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR70 Gene

Pathways & Interactions for WDR70 Gene

SuperPathways for WDR70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR70 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR70 Gene

Drugs & Compounds for WDR70 Gene

No Compound Related Data Available

Transcripts for WDR70 Gene

Unigene Clusters for WDR70 Gene

WD repeat domain 70:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR70

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR70 Gene

No ASD Table

Relevant External Links for WDR70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR70 Gene

mRNA expression in normal human tissues for WDR70 Gene

Protein differential expression in normal tissues from HIPED for WDR70 Gene

This gene is overexpressed in Esophagus (36.9) and Lung (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR70 Gene

SOURCE GeneReport for Unigene cluster for WDR70 Gene Hs.213690

genes like me logo Genes that share expression patterns with WDR70: view

Protein tissue co-expression partners for WDR70 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR70 Gene

Orthologs for WDR70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR70 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR70 35
  • 91.72 (n)
  • 94.63 (a)
WDR70 36
  • 95 (a)
(Canis familiaris)
Mammalia LOC489225 35
  • 93.87 (n)
  • 97.7 (a)
WDR70 36
  • 95 (a)
(Mus musculus)
Mammalia Wdr70 35
  • 88.02 (n)
  • 90.83 (a)
Wdr70 16
Wdr70 36
  • 91 (a)
(Pan troglodytes)
Mammalia WDR70 35
  • 99.54 (n)
  • 99.54 (a)
WDR70 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr70 35
  • 89.19 (n)
  • 92.66 (a)
(Monodelphis domestica)
Mammalia WDR70 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 89 (a)
-- 36
  • 74 (a)
(Gallus gallus)
Aves WDR70 35
  • 74.03 (n)
  • 76.47 (a)
WDR70 36
  • 75 (a)
(Anolis carolinensis)
Reptilia WDR70 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7113 35
wdr70 35
  • 73.56 (n)
  • 78.65 (a)
(Danio rerio)
Actinopterygii LOC101884837 35
  • 69.49 (n)
  • 70.9 (a)
WDR70 (1 of 2) 36
  • 75 (a)
WDR70 (2 of 2) 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5543 35
  • 55.56 (n)
  • 50.49 (a)
CG5543 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea gad-1 35
gad-1 36
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G20330 35
  • 52.16 (n)
  • 43.7 (a)
(Oryza sativa)
Liliopsida Os.12790 35
Os10g0464100 35
  • 50.51 (n)
  • 44.66 (a)
(Zea mays)
Liliopsida Zm.12874 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11370 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for WDR70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR70 Gene

Gene Tree for WDR70 (if available)
Gene Tree for WDR70 (if available)

Paralogs for WDR70 Gene Pseudogenes for WDR70 Gene

genes like me logo Genes that share paralogs with WDR70: view

No data available for Paralogs for WDR70 Gene

Variants for WDR70 Gene

Structural Variations from Database of Genomic Variants (DGV) for WDR70 Gene

Variant ID Type Subtype PubMed ID
nsv881511 CNV Gain 21882294
dgv6037n71 CNV Gain 21882294
nsv881076 CNV Gain 21882294
nsv471012 CNV Gain 18288195
nsv880327 CNV Gain 21882294
nsv880890 CNV Gain 21882294
esv2661091 CNV Deletion 23128226
esv2665634 CNV Deletion 23128226
esv28527 CNV Loss 19812545
nsv881383 CNV Gain 21882294
esv2730085 CNV Deletion 23290073
esv2677567 CNV Deletion 23128226
nsv881497 CNV Loss 21882294
nsv819667 CNV Loss 19587683
esv259629 OTHER Complex 20981092
esv2730086 CNV Deletion 23290073
nsv329607 CNV Loss 16902084
esv2730087 CNV Deletion 23290073
esv2591687 CNV Deletion 19546169
esv267643 CNV Insertion 20981092
esv2730088 CNV Deletion 23290073
esv270338 CNV Insertion 20981092

Variation tolerance for WDR70 Gene

Residual Variation Intolerance Score: 9.16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR70 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for WDR70 Gene

Disorders for WDR70 Gene

Relevant External Links for WDR70

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR70: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR70 Gene

Publications for WDR70 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 67
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PMID: 23382074) Armour S.M. … Sinclair D.A. (Mol. Cell. Biol. 2013) 67

Products for WDR70 Gene

Sources for WDR70 Gene

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