WDR70 Gene
protein-coding GIFtS: 41
GCID: GC05P037380
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WD repeat domain 70
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Aliases
for WDR70 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 701 2 | | FLJ102331 | | WD Repeat-Containing Protein 702 |
Export aliases for WDR70 gene to outside databasesPrevious GC identifers: GC05P037416 GC05P037331 |
Summaries
for WDR70 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR70 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR70 gene promoter:
GR C/EBPbeta MIF-1 NF-AT NF-AT2 E2F-1 E2F SEF-1 (1) GR-alpha NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR70
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR70 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.2 Ensembl cytogenetic band: 5p13.2 HGNC cytogenetic band: 5p13.2WDR70 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P037380: view genomic region
(about GC identifiers)
Start:
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37,379,314 bp from pter |
End:
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37,753,537 bp from pter |
Size:
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374,224 bases |
Orientation:
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plus strand |
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Proteins
for WDR70 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR70_HUMAN, Q9NW82 (See
protein sequence)Recommended Name: WD repeat-containing protein 70 Size: 654 amino acids; 73201 Da
Sequence caution: Sequence=CAC21644.1; Type=Erroneous initiation;
Secondary accessions: Q9H053Explore the universe of human proteins at neXtProt for WDR70: NX_Q9NW82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NW82
WDR70 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060504.1
ENSEMBL proteins: ENSP00000265107 ENSP00000425841
Human Recombinant Protein Products:
WDR70 Antibody Products:
Assay Products for WDR70: |
Protein
Domains /
Families
for WDR70 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR70 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NW82ProtoNet protein and cluster: Q9NW82 UniProtKB/Swiss-Prot: WDR70_HUMAN, Q9NW82Similarity: Belongs to the WD repeat GAD-1 familySimilarity: Contains 7 WD repeats |
Function
for WDR70 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR70 (NM_018034) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR70 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR70 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR70 |
3 GenomeRNAi human phenotypes for WDR70:
|
Pathways & Interactions
for WDR70 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR70
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for WDR70 (Q9NW823 ENSP000002651074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR70 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR70
Search CenterWatch for drugs/clinical trials and news about WDR70
|
Transcripts
for WDR70 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR70 gene: NM_018034.2 Unigene Cluster for WDR70: WD repeat domain 70 Hs.213690 [show with all ESTs]Unigene Representative Sequence: BX5376557 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265107(uc003jkv.3) ENST00000504564(uc010iva.1) ENST00000511906
ENST00000505799 ENST00000510699 ENST00000507136 ENST00000508730
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR70 (NM_018034) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR70 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR70 |
Additional cDNA sequence: AK001095.1 AK291179.1 AK310901.1 AL512685.1 BC009648.1 BC025315.1 BX537655.1 4 DOTS entries: DT.411849 DT.100025289 DT.100665911 DT.100747870 24/103 AceView cDNA sequences (see all 103): CN481774 BC009648 AA179602 BQ649486 NM_018034 AA582323 BM476705 BU146540 BQ647961 AK001095 BI258449 BQ654135 BC025315 AU120245 BM979954 BM465577 BX325272 CR597628 BE280787 CD244814 CB045128 BQ064814 BQ059157 BX100288
GeneLoc Exon Structure
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Expression
for WDR70 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR70 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAATTAAAAA
About this image
See WDR70 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR70
SOURCE GeneReport for Unigene cluster: Hs.213690
SABiosciences Custom PCR Arrays for WDR70
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR70
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR70 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR70 |
Orthologs
for WDR70 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR70 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for WDR70 (if available)
TreeFam Gene Tree for WDR70 (if available) |
Paralogs
for WDR70 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR70 gene
WDR70 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for WDR70
PGOHUM00000237815 PGOHUM00000235340 PGOHUM00000235712
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Genomic Variants
for WDR70 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR70 (37379314 - 37629314 bp, first 250kb of WDR70)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for WDR70
3 CNVs: 69055 99114 59263 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR70 |
|
Disorders
/ Diseases
for WDR70 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR70 for disorders About GeneDecksing
1  disease for WDR70: About MalaCardsmalaria
Export disorders for WDR70 gene to outside databases
|
Publications
for WDR70 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR70 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with WDR70) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
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External Searches for WDR70 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR70 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR70 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR70 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR70 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for WDR70 gene:
Search GeneIP for patents involving WDR70
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR70 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR70 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR70 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR70 | | | OriGene Protein Over-expression Lysate for WDR70 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR70 | | OriGene 3'-UTR Clone for WDR70 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR70 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR70 | | OriGene Custom Protein Services for WDR70 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR70 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR70 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR70 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR70 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR70 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR70 |
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| | | | Search Tocris compounds for WDR70 |
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 | | | WDR70 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR70 |
|  |  |  | | | | Search ThermoFisher Antibodies for WDR70 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR70 |
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