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Aliases for WDR7 Gene

Aliases for WDR7 Gene

  • WD Repeat Domain 7 2 3
  • TRAG 3 4 6
  • TGF-Beta Resistance-Associated Protein TRAG 3 4
  • Rabconnectin-3 Beta 3 4
  • KIAA0541 4 6
  • TGF-Beta Resistance Associated 3
  • WD Repeat-Containing Protein 7 3

External Ids for WDR7 Gene

Previous GeneCards Identifiers for WDR7 Gene

  • GC18P054428
  • GC18P054221
  • GC18P054103
  • GC18P052488
  • GC18P052490
  • GC18P054318
  • GC18P051029

Summaries for WDR7 Gene

Entrez Gene Summary for WDR7 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR7 Gene

WDR7 (WD Repeat Domain 7) is a Protein Coding gene. An important paralog of this gene is WDR72.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR7 Gene

Genomics for WDR7 Gene

Regulatory Elements for WDR7 Gene

Genomic Location for WDR7 Gene

56,651,343 bp from pter
57,036,606 bp from pter
385,264 bases
Plus strand

Genomic View for WDR7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR7 Gene

Proteins for WDR7 Gene

  • Protein details for WDR7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A7E2C8
    • Q86UX5
    • Q86VP2
    • Q96PS7

    Protein attributes for WDR7 Gene

    1490 amino acids
    Molecular mass:
    163810 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25467.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR7 Gene


neXtProt entry for WDR7 Gene

Proteomics data for WDR7 Gene at MOPED

Post-translational modifications for WDR7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR7 Gene

Domains for WDR7 Gene

Gene Families for WDR7 Gene

  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y4E6
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR7: view

Function for WDR7 Gene

Gene Ontology (GO) - Molecular Function for WDR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR7: view

Phenotypes for WDR7 Gene

GenomeRNAi human phenotypes for WDR7:
genes like me logo Genes that share phenotypes with WDR7: view

Animal Model Products

miRNA for WDR7 Gene

miRTarBase miRNAs that target WDR7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR7 Gene

Localization for WDR7 Gene

Subcellular locations from

Jensen Localization Image for WDR7 Gene COMPARTMENTS Subcellular localization image for WDR7 gene
Compartment Confidence
peroxisome 2
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR7 Gene

Pathways for WDR7 Gene

SuperPathways for WDR7 Gene

No Data Available

Interacting Proteins for WDR7 Gene

Gene Ontology (GO) - Biological Process for WDR7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with WDR7: view

No data available for Pathways by source for WDR7 Gene

Transcripts for WDR7 Gene

Unigene Clusters for WDR7 Gene

WD repeat domain 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - - -
SP3: - - - -
SP5: -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b

Relevant External Links for WDR7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR7 Gene

mRNA expression in normal human tissues for WDR7 Gene

Protein differential expression in normal tissues for WDR7 Gene

This gene is overexpressed in Frontal cortex (34.8), Brain (9.9), and Fetal Brain (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR7 Gene

SOURCE GeneReport for Unigene cluster for WDR7 Gene Hs.465213

genes like me logo Genes that share expressions with WDR7: view

Expression partners for WDR7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR7 Gene

Orthologs for WDR7 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR7 35
  • 88.84 (n)
  • 96.24 (a)
WDR7 36
  • 96 (a)
(Canis familiaris)
Mammalia WDR7 35
  • 92.24 (n)
  • 97.18 (a)
WDR7 36
  • 97 (a)
(Mus musculus)
Mammalia Wdr7 35
  • 87.28 (n)
  • 95.1 (a)
Wdr7 16
Wdr7 36
  • 95 (a)
(Pan troglodytes)
Mammalia WDR7 35
  • 99.22 (n)
  • 99.53 (a)
WDR7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr7 35
  • 87.34 (n)
  • 94.68 (a)
(Monodelphis domestica)
Mammalia WDR7 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia WDR7 36
  • 93 (a)
(Gallus gallus)
Aves WDR7 35
  • 79.69 (n)
  • 90.59 (a)
WDR7 36
  • 90 (a)
(Anolis carolinensis)
Reptilia WDR7 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr7 35
  • 76.78 (n)
  • 87.21 (a)
(Danio rerio)
Actinopterygii wdr7 35
  • 68.56 (n)
  • 77.25 (a)
CABZ01073424.1 36
  • 87 (a)
WDR7 36
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:86E4.3 37
  • 39 (a)
Rbcn-3B 35
  • 51.25 (n)
  • 46.12 (a)
Rbcn-3B 36
  • 41 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008003 35
  • 24.48 (n)
  • 5.16 (a)
(Caenorhabditis elegans)
Secernentea Y54F10AM.10 37
  • 36 (a)
Y54F10AM.9 37
  • 39 (a)
rbc-2 35
  • 47.13 (n)
  • 38.04 (a)
rbc-2 36
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for WDR7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR7 Gene

Gene Tree for WDR7 (if available)
Gene Tree for WDR7 (if available)

Paralogs for WDR7 Gene

Paralogs for WDR7 Gene

Selected SIMAP similar genes for WDR7 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with WDR7: view

Variants for WDR7 Gene

Sequence variations from dbSNP and Humsavar for WDR7 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs4121 -- 56,799,604(-) TGTGC(G/T)TGGTA intron-variant
rs471036 -- 56,681,049(+) GACTT(C/T)ATTAA intron-variant
rs474607 -- 56,681,419(+) CTAAG(C/T)ACAAA intron-variant
rs475035 -- 56,698,232(+) GGTCA(C/T)GCTCT intron-variant
rs477415 -- 56,651,868(-) TTAGA(A/T)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR7 Gene

Variant ID Type Subtype PubMed ID
esv271272 CNV Insertion 20981092
esv273667 CNV Insertion 20981092
nsv524292 CNV Loss 19592680
nsv521938 CNV Gain 19592680
nsv2317 CNV Insertion 18451855
nsv517361 CNV Gain+Loss 19592680
esv259896 OTHER Complex 20981092
esv1004514 CNV Insertion 20482838
nsv817793 CNV Gain 17921354
nsv516762 CNV Loss 19592680
nsv909660 CNV Gain 21882294
esv269189 CNV Insertion 20981092
nsv909661 CNV Gain 21882294
nsv510943 CNV Complex 20534489
dgv497e201 CNV Deletion 23290073
esv2661652 CNV Deletion 23128226
esv1419362 CNV Insertion 17803354
esv2717142 CNV Deletion 23290073
esv1508428 CNV Insertion 17803354

Relevant External Links for WDR7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR7 Gene

Disorders for WDR7 Gene

(1) University of Copenhagen DISEASES for WDR7 Gene

Relevant External Links for WDR7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WDR7: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for WDR7 Gene

Publications for WDR7 Gene

  1. Assignment of WDR7 (alias TRAG, TGF-beta resistance associated gene) to orthologous regions of human chromosome 18q21.1-->q22 and mouse chromosome 18D.1-E.3 by fluorescence in situ hybridization. (PMID: 10828621) Sanders S. … Thorgeirsson S.S. (Cytogenet. Cell Genet. 2000) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  3. A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)- dependent exocytosis of neurotransmitter. (PMID: 12786944) Kawabe H. … Takai Y. (Genes Cells 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 48

Products for WDR7 Gene

Sources for WDR7 Gene

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