WDR67 Gene
protein-coding GIFtS: 43
GCID: GC08P124054
|
|
WD repeat domain 67
| |
Aliases
for WDR67 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 671 2 | | Gm851 2 | | MGC216541 | | WD Repeat-Containing Protein 672 |
Export aliases for WDR67 gene to outside databasesPrevious GC identifers: GC08P124155 GC08P119410 |
Summaries
for WDR67 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR67 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR67 gene promoter:
c-Fos Bach1 RFX1 AP-1 JunB Fra-1 FosB JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR67
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR67 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.13 Ensembl cytogenetic band: 8q24.13 HGNC cytogenetic band: 8q24.13WDR67 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P124054: view genomic region
(about GC identifiers)
Start:
|
124,054,208 bp from pter |
End:
|
124,164,393 bp from pter |
Size:
|
110,186 bases |
Orientation:
|
plus strand |
|
Proteins
for WDR67 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR67_HUMAN, Q96DN5 (See
protein sequence)Recommended Name: WD repeat-containing protein 67 Size: 1066 amino acids; 124189 Da
Sequence caution: Sequence=AAH27237.1; Type=Erroneous initiation;
Secondary accessions: B7ZL19 Q2M2J9 Q3MIR6 Q8TBP9Alternative splicing: 3 isoforms: Q96DN5-1 Q96DN5-2 Q96DN5-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR67: NX_Q96DN5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96DN5
WDR67 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138560.1 NP_663622.2
ENSEMBL proteins: ENSP00000428486 ENSP00000287380 ENSP00000430927 ENSP00000312701 ENSP00000429334 ENSP00000430628 ENSP00000440772 ENSP00000428891 ENSP00000427848 ENSP00000432525 ENSP00000429494 ENSP00000432064 ENSP00000308358 ENSP00000367320
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WDR67 for ontologies About GeneDecksing
WDR67 Antibody Products:
Assay Products for WDR67: |
Protein
Domains /
Families
for WDR67 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR67 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96DN5ProtoNet protein and cluster: Q96DN5 UniProtKB/Swiss-Prot: WDR67_HUMAN, Q96DN5Similarity: Contains 1 Rab-GAP TBC domainSimilarity: Contains 5 WD repeats |
Function
for WDR67 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDR67 (NM_001145088) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR67 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR67 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR67 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005097 | Rab GTPase activator activity |
IEA | -- |
WDR67 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for WDR67:
|
Pathways & Interactions
for WDR67 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR67
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for WDR67 (ENSP000002873804) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR67 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR67
Search CenterWatch for drugs/clinical trials and news about WDR67
|
Transcripts
for WDR67 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR67 gene (2 alternative transcripts): NM_001145088.1 NM_145647.3 Unigene Cluster for WDR67: WD repeat domain 67 Hs.492716 [show with all ESTs]Unigene Representative Sequence: NM_14564717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000520368 ENST00000287380(uc003ypp.2 uc011lih.2 uc003yps.2)
ENST00000519418 ENST00000327098 ENST00000522420 ENST00000518099(uc003ypo.1)
ENST00000521676(uc003ypu.2) ENST00000524307 ENST00000522276 ENST00000518684
ENST00000521980 ENST00000521914(uc003ypr.3) ENST00000518805 ENST00000518577
ENST00000518866 ENST00000309336(uc011lig.2 uc003ypq.2) ENST00000378080
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR67 (NM_001145088) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR67 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR67 |
Additional cDNA sequence: AK025686.1 AK056434.1 AK092041.2 BC026969.1 BC027237.1 BC101724.1 BC105800.1 BC111954.1 BC143523.1 BC143525.1 U43374.1 13 DOTS entries: DT.455248 DT.99973440 DT.95219850 DT.97782482 DT.97821362 DT.100021430 DT.121483264 DT.100021431 DT.101960551 DT.101983892 DT.121483249 DT.95265583 DT.121483235 24/75 AceView cDNA sequences (see all 75): CR594827 CB856456 BC026969 N77703 AA405339 AA237083 AA262702 BX103373 CR596842 AA405338 AK092041 BX364001 AI375390 BQ436515 BX103539 AI017564 AK094612 BM852752 AK025686 CA429516 BM823743 CB131082 BM931015 BM684501
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WDR67 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | - | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR67
|
Expression
for WDR67 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR67 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCTTGAG
About this image
See WDR67 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR67
SOURCE GeneReport for Unigene cluster: Hs.492716
SABiosciences Custom PCR Arrays for WDR67
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR67
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR67 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR67 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR67 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR67 |
Orthologs
for WDR67 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR67 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for WDR67 (if available)
TreeFam Gene Tree for WDR67 (if available) |
Paralogs
for WDR67 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR67 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR67 (124054208 - 124164393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR67: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR67 |
|
Disorders
/ Diseases
for WDR67 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WDR67 for disorders About MalaCards
WDR67 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: WDR67 (1 document)
Export disorders for WDR67 gene to outside databases
|
Publications
for WDR67 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR67 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR67) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
|
External Searches for WDR67 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR67 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR67 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR67 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR67 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR67 gene:
Search GeneIP for patents involving WDR67
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR67 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR67 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR67 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR67 | | | OriGene Protein Over-expression Lysate for WDR67 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR67 | | OriGene 3'-UTR Clone for WDR67 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR67 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR67 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR67 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR67 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR67 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR67 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR67 |
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 | | | WDR67 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR67 |
|  |  |  | | | | ThermoFisher Antibodies for WDR67 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR67 |
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