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Aliases for WDR66 Gene

Aliases for WDR66 Gene

  • WD Repeat Domain 66 2 3 5
  • WD Repeat-Containing Protein 66 3 4
  • CFAP251 3 4
  • Cilia- And Flagella-Associated Protein 251 3
  • CaM-IP4 3

External Ids for WDR66 Gene

Previous GeneCards Identifiers for WDR66 Gene

  • GC12P120820
  • GC12P122356
  • GC12P119367
  • GC12P121951
  • GC12P121954
  • GC12P121959
  • GC12P121966
  • GC12P121972

Summaries for WDR66 Gene

Entrez Gene Summary for WDR66 Gene

  • This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for WDR66 Gene

WDR66 (WD Repeat Domain 66) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for WDR66 Gene

  • May regulate cilium motility through its role in the assembly of the axonemal radial spokes.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR66 Gene

Genomics for WDR66 Gene

Regulatory Elements for WDR66 Gene

Enhancers for WDR66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G121923 1.5 FANTOM5 Ensembl ENCODE 38.6 +6.9 6941 3.3 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ETS1 TCF12 SP5 PPARG WDR66 PSMD9 ENSG00000256950 HPD GC12P122009
GH12G122020 1.7 FANTOM5 ENCODE dbSUPER 29 +105.2 105194 4.5 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS LINC01089 WDR66 ENSG00000272849 ARL6IP4 LOC101928346 BCL7A ENSG00000255856 LOC100506691
GH12G122002 1.5 FANTOM5 Ensembl ENCODE dbSUPER 28.5 +87.0 87025 4.1 HINFP YBX1 ZNF121 ZNF366 POLR2A MTA2 ZBTB2 BHLHE40 NRF1 ZBTB7A WDR66 PSMD9 HPD LINC01089 SETD1B ENSG00000256950 LRRC43 B3GNT4 DIABLO BCL7A
GH12G121917 0.9 ENCODE 39.1 +0.5 509 1.5 HDGF PKNOX1 ARNT SIN3A BMI1 RAD21 ZBTB40 RFX5 EGR1 ELK1 WDR66 GC12P122009
GH12G121949 1 Ensembl ENCODE 30.7 +32.5 32531 2.6 BHLHE40 ZNF10 MAFG SREBF1 JUND ZNF316 RAD51 ZNF366 NFE2L1 ZBTB33 WDR66 PSMD9 RNU7-170P BCL7A ENSG00000255856 ENSG00000256950 HPD GC12P122009
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR66 on UCSC Golden Path with GeneCards custom track

Promoters for WDR66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058518 43 401 HDGF PKNOX1 ARNT SIN3A BMI1 RAD21 ZBTB40 RFX5 EGR1 ELK1

Genomic Location for WDR66 Gene

Chromosome:
12
Start:
121,917,862 bp from pter
End:
122,003,927 bp from pter
Size:
86,066 bases
Orientation:
Plus strand

Genomic View for WDR66 Gene

Genes around WDR66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR66 Gene

Proteins for WDR66 Gene

  • Protein details for WDR66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBY9-CF251_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 251
    Protein Accession:
    Q8TBY9
    Secondary Accessions:
    • C9J1W2
    • Q8IYA3
    • Q8N898
    • Q8NDE7

    Protein attributes for WDR66 Gene

    Size:
    1149 amino acids
    Molecular mass:
    129952 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR66 Gene

Post-translational modifications for WDR66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR66 Gene

Domains & Families for WDR66 Gene

Gene Families for WDR66 Gene

Suggested Antigen Peptide Sequences for WDR66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR66: view

No data available for UniProtKB/Swiss-Prot for WDR66 Gene

Function for WDR66 Gene

Molecular function for WDR66 Gene

UniProtKB/Swiss-Prot Function:
May regulate cilium motility through its role in the assembly of the axonemal radial spokes.
genes like me logo Genes that share phenotypes with WDR66: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR66 Gene

Localization for WDR66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR66 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR66 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
plasma membrane 2
nucleus 2

Gene Ontology (GO) - Cellular Components for WDR66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001536 colocalizes_with radial spoke stalk ISS --
GO:0005737 cytoplasm IEA --
GO:0005930 axoneme ISS --
GO:0031514 motile cilium ISS --
genes like me logo Genes that share ontologies with WDR66: view

Pathways & Interactions for WDR66 Gene

SuperPathways for WDR66 Gene

No Data Available

Interacting Proteins for WDR66 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288912%0d%0a9606.ENSP00000381565%0d%0a
Selected Interacting proteins: Q8TBY9-CF251_HUMAN ENSP00000288912 for WDR66 Gene via IID STRING

Gene Ontology (GO) - Biological Process for WDR66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement ISS --
genes like me logo Genes that share ontologies with WDR66: view

No data available for Pathways by source and SIGNOR curated interactions for WDR66 Gene

Drugs & Compounds for WDR66 Gene

No Compound Related Data Available

Transcripts for WDR66 Gene

Unigene Clusters for WDR66 Gene

WD repeat domain 66:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR66 Gene

No ASD Table

Relevant External Links for WDR66 Gene

GeneLoc Exon Structure for
WDR66
ECgene alternative splicing isoforms for
WDR66

Expression for WDR66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR66 Gene

mRNA differential expression in normal tissues according to GTEx for WDR66 Gene

This gene is overexpressed in Testis (x7.8) and Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for WDR66 Gene

This gene is overexpressed in Pancreatic juice (37.9), Heart (20.8), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR66 Gene



Protein tissue co-expression partners for WDR66 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR66 Gene:

WDR66

SOURCE GeneReport for Unigene cluster for WDR66 Gene:

Hs.709837

Evidence on tissue expression from TISSUES for WDR66 Gene

  • Spleen(4.1)
genes like me logo Genes that share expression patterns with WDR66: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR66 Gene

Orthologs for WDR66 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR66 34 35
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia WDR66 34 35
  • 84.15 (n)
cow
(Bos Taurus)
Mammalia WDR66 34 35
  • 83.53 (n)
mouse
(Mus musculus)
Mammalia Wdr66 34 16 35
  • 79.8 (n)
rat
(Rattus norvegicus)
Mammalia Wdr66 34
  • 79.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR66 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR66 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR66 34 35
  • 60.68 (n)
lizard
(Anolis carolinensis)
Reptilia WDR66 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr66 34
  • 58.1 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr66 34 35
  • 54.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007799 34
  • 43.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
Species where no ortholog for WDR66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR66 Gene

ENSEMBL:
Gene Tree for WDR66 (if available)
TreeFam:
Gene Tree for WDR66 (if available)

Paralogs for WDR66 Gene

No data available for Paralogs for WDR66 Gene

Variants for WDR66 Gene

Sequence variations from dbSNP and Humsavar for WDR66 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000014411 -- 121,957,519(+) CTAAC(A/G)TGGTG intron-variant
rs1000024563 -- 121,922,951(+) CGCCC(A/G)GCTAA intron-variant
rs1000041263 -- 121,930,269(+) GGATC(A/C)TGAGG intron-variant
rs1000042344 -- 121,950,254(+) TGGAA(A/T)GTCCA intron-variant
rs1000092876 -- 122,000,077(+) CCATG(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR66 Gene

Variant ID Type Subtype PubMed ID
esv2659581 CNV deletion 23128226
esv3630963 CNV loss 21293372
esv3630964 CNV loss 21293372
esv3630965 CNV gain 21293372

Variation tolerance for WDR66 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.16; 99.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR66 Gene

Human Gene Mutation Database (HGMD)
WDR66
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR66 Gene

Disorders for WDR66 Gene

Relevant External Links for WDR66

Genetic Association Database (GAD)
WDR66
Human Genome Epidemiology (HuGE) Navigator
WDR66
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR66

No disorders were found for WDR66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR66 Gene

Publications for WDR66 Gene

  1. A genome-wide association study of metabolic traits in human urine. (PMID: 21572414) Suhre K. … Nauck M. (Nat. Genet. 2011) 3 46 64
  2. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
  3. A genome-wide association study identifies three loci associated with mean platelet volume. (PMID: 19110211) Meisinger C. … DAPring A. (Am. J. Hum. Genet. 2009) 3 46 64
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  5. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 46 64

Products for WDR66 Gene

Sources for WDR66 Gene

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