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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR66 Gene

protein-coding   GIFtS: 43
GCID: GC12P122356

WD Repeat Domain 66

  Search for WDR66
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 661 2
WD Repeat-Containing Protein 662

External Ids:    HGNC: 285061   Entrez Gene: 1444062   Ensembl: ENSG000001580237   UniProtKB: Q8TBY93   

Export aliases for WDR66 gene to outside databases

Previous GC identifers: GC12P120820 GC12P119367


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR66 Gene:
This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the
formation of protein-protein complexes in a variety of biological pathways. This family member appears to
function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated
with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. (provided by
RefSeq, Sep 2011)

GeneCards Summary for WDR66 Gene: 
WDR66 (WD repeat domain 66) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR66 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   Nkx2-5   STAT1alpha   STAT2   STAT3   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR66 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR66

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

WDR66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR66 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122356:  view genomic region     (about GC identifiers)

Start:
122,355,768 bp from pter      End:
122,441,833 bp from pter
Size:
86,066 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR66_HUMAN, Q8TBY9 (See protein sequence)
Recommended Name: WD repeat-containing protein 66  
Size: 1149 amino acids; 129952 Da
Secondary accessions: C9J1W2 Q8IYA3 Q8N898 Q8NDE7
Alternative splicing: 3 isoforms:  Q8TBY9-1   Q8TBY9-2   Q8TBY9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR66: NX_Q8TBY9

Explore proteomics data for WDR66 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TBY9

  • WDR66 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR66 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171474.1  NP_653269.3  

    ENSEMBL proteins: 
     ENSP00000288912   ENSP00000380595  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TBY9

    ProtoNet protein and cluster: Q8TBY9

    UniProtKB/Swiss-Prot: WDR66_HUMAN, Q8TBY9
    Similarity: Contains 9 WD repeats


    WDR66 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    WDR66 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR66:
     Decreased viability of wild-ty 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR66

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR66

    Search CenterWatch for drugs/clinical trials and news about WDR66

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR66 gene (2 alternative transcripts): 
    NM_001178003.1  NM_144668.5  

    Unigene Cluster for WDR66:

    WD repeat domain 66
    Hs.709837  [show with all ESTs]
    Unigene Representative Sequence: NM_144668
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288912(uc009zxk.3) ENST00000397454(uc021rfh.1) ENST00000540779
    ENST00000546044 ENST00000543211 ENST00000535257 ENST00000545752 ENST00000428465
    ENST00000545988
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR66:
    hsa-miR-2113
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR66
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR66

    Additional mRNA sequence: 

    AK307298.1 AL833930.1 BC028421.2 BC036233.1 

    9 DOTS entries:

    DT.97827452  DT.92041564  DT.97822269  DT.40281989  DT.445685  DT.121119424  DT.91828496  DT.97827453 
    DT.99933529 

    24/280 AceView cDNA sequences (see all 280):

    BX116425 N57237 BM826633 NM_002813 BU740504 BM977486 AA640616 BI493839 
    BG149414 BM713768 AA448270 BM823054 AI580764 BG676155 BM552926 AI202368 
    CB241016 AA337357 CB241096 CR624376 AL037250 BU738828 BC002383 BE466812 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR66 expression in normal human tissues (normalized intensities)      WDR66 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCACTGCT
    WDR66 Expression
    About this image


    WDR66 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See WDR66 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR66

    SOURCE GeneReport for Unigene cluster: Hs.709837
        SABiosciences Custom PCR Arrays for WDR66
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR66

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDR66 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr661 , 5 WD repeat domain 661, 5 74.26(n)1
    72.46(a)1
      5 (62.86 cM)5
    2697011  XM_485681.71  XP_485681.71 
     1232521025 
    chicken
    (Gallus gallus)
    Aves WDR661 WD repeat domain 66 60.19(n)
    52.65(a)
      416855  XM_415147.3  XP_415147.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR666
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343550.1(342936-379511)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ082172.12   -- 73.89(n)    BJ082172.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr661 WD repeat domain 66 54.44(n)
    45.21(a)
      569257  XM_692631.4  XP_697723.4 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0077991 AGAP007799-PA 43.33(n)
    28.64(a)
      3291590  XM_555730.2  XP_555730.2 


    ENSEMBL Gene Tree for WDR66 (if available)
    TreeFam Gene Tree for WDR66 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1898 SNPs in WDR66 are shown (see all 1898)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110432421,2
    C,F,H--122356293(+) GGGACG/CGGACC 2 -- us2k114Minor allele frequency- C:0.37NS EA NA WA CSA 765
    rs110432431,2
    C,F,A,H--122356370(+) CGACCG/CGCAGG 2 -- us2k110Minor allele frequency- C:0.25NS EA NA 536
    rs123013161,2
    C,F,H--122356386(+) CGTCGG/CGCACG 2 -- us2k17Minor allele frequency- C:0.04NS EA WA CSA 530
    rs107431851,2
    C,F,A,H--122356435(+) CTGTCA/GCTTTA 2 -- us2k17Minor allele frequency- G:0.43WA NA EA 368
    rs107431861,2
    C,F,A,H--122356436(+) TGTCGT/CTTTAG 2 -- us2k17Minor allele frequency- C:0.44NA WA EA 368
    rs752534291,2
    C,F--122356479(+) GGGGAC/TGGAGC 2 -- ut512Minor allele frequency- T:0.03NA EA 240
    rs1853107351,2
    --122356530(+) GCGGCC/TGCTGG 2 -- ut510--------
    rs1460893501,2
    --122356810(+) CTGCCC/GCAAAC 2 -- int10--------
    rs1891376471,2
    --122356913(+) AGCAGC/TGATTT 2 -- int10--------
    rs665394791,2
    C--122357027(+) TTTAT-/T/TTTA
            
    TTATT
    2 -- int11CSA 2

    HapMap Linkage Disequilibrium report for WDR66 (122355768 - 122441833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WDR66:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2659581CNV Deletion23128226
    nsv899568CNV Gain21882294


    Human Gene Mutation Database (HGMD): WDR66
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR66
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR66

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDR66 for disorders           About MalaCards

    WDR66 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR66
    Human Genome Epidemiology (HuGE) Navigator: WDR66 (2 documents)

    Export disorders for WDR66 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR66 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with WDR66)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of metabolic traits i n human urine. (PubMed id 21572414)1, 4 Suhre K....Nauck M. (2011)
    2. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    3. A genome-wide meta-analysis identifies 22 loci associ ated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (2009)
    4. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    5. A genome-wide association study identifies three loci associated with mean platelet volume. (PubMed id 19110211)1, 4 Meisinger C....DAPring A. (2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    8. Wdr66 is a novel marker for risk stratification and in volved in epithelial-mesenchymal transition of esophageal squamous cell carcinom a. (PubMed id 23514407)1 Wang Q....Kemmner W. (2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Analysis of indel variations in the human disease-asso ciated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. (PubMed id 22552337)1 Kim R.N....Park H.S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144406 HGNC: 28506 AceView: PSMD9andMGC33630 Ensembl:ENSG00000158023 euGenes: HUgn144406
    ECgene: WDR66 H-InvDB: WDR66

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR66 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR66 gene:
    Search GeneIP for patents involving WDR66

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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