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Aliases for WDR66 Gene

Aliases for WDR66 Gene

  • WD Repeat Domain 66 2 3
  • CaM-IP4 3

External Ids for WDR66 Gene

Previous GeneCards Identifiers for WDR66 Gene

  • GC12P120820
  • GC12P122356
  • GC12P119367
  • GC12P121951

Summaries for WDR66 Gene

Entrez Gene Summary for WDR66 Gene

  • This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for WDR66 Gene

WDR66 (WD Repeat Domain 66) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR66 Gene

Genomics for WDR66 Gene

Regulatory Elements for WDR66 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR66 Gene

121,917,862 bp from pter
122,003,927 bp from pter
86,066 bases
Plus strand

Genomic View for WDR66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR66 Gene

Proteins for WDR66 Gene

  • Protein details for WDR66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 66
    Protein Accession:
    Secondary Accessions:
    • C9J1W2
    • Q8IYA3
    • Q8N898
    • Q8NDE7

    Protein attributes for WDR66 Gene

    1149 amino acids
    Molecular mass:
    129952 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR66 Gene


neXtProt entry for WDR66 Gene

Proteomics data for WDR66 Gene at MOPED

Post-translational modifications for WDR66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR66 Gene

Domains & Families for WDR66 Gene

Gene Families for WDR66 Gene

Suggested Antigen Peptide Sequences for WDR66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 WD repeats.
  • Contains 9 WD repeats.
genes like me logo Genes that share domains with WDR66: view

Function for WDR66 Gene

Gene Ontology (GO) - Molecular Function for WDR66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR66: view
genes like me logo Genes that share phenotypes with WDR66: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR66

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR66 Gene

Localization for WDR66 Gene

Subcellular locations from

Jensen Localization Image for WDR66 Gene COMPARTMENTS Subcellular localization image for WDR66 gene
Compartment Confidence
cytosol 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR66 Gene

Pathways & Interactions for WDR66 Gene

SuperPathways for WDR66 Gene

No Data Available

Interacting Proteins for WDR66 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000288912 for WDR66 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WDR66 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR66 Gene

Drugs & Compounds for WDR66 Gene

No Compound Related Data Available

Transcripts for WDR66 Gene

Unigene Clusters for WDR66 Gene

WD repeat domain 66:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR66

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR66 Gene

No ASD Table

Relevant External Links for WDR66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR66 Gene

mRNA expression in normal human tissues for WDR66 Gene

mRNA differential expression in normal tissues according to GTEx for WDR66 Gene

This gene is overexpressed in Testis (x7.8) and Pituitary (x4.6).

Protein differential expression in normal tissues from HIPED for WDR66 Gene

This gene is overexpressed in Pancreatic juice (37.9), Heart (20.8), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR66 Gene

SOURCE GeneReport for Unigene cluster for WDR66 Gene Hs.709837

genes like me logo Genes that share expression patterns with WDR66: view

Protein tissue co-expression partners for WDR66 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR66 Gene

Orthologs for WDR66 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR66 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR66 35
  • 83.53 (n)
  • 80.51 (a)
WDR66 36
  • 77 (a)
(Canis familiaris)
Mammalia WDR66 35
  • 84.15 (n)
  • 80.7 (a)
WDR66 36
  • 79 (a)
(Mus musculus)
Mammalia Wdr66 35
  • 79.8 (n)
  • 80.46 (a)
Wdr66 16
Wdr66 36
  • 62 (a)
(Pan troglodytes)
Mammalia WDR66 35
  • 98.96 (n)
  • 98.61 (a)
WDR66 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr66 35
  • 79.23 (n)
  • 79.12 (a)
(Monodelphis domestica)
Mammalia WDR66 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia WDR66 36
  • 57 (a)
(Gallus gallus)
Aves WDR66 35
  • 60.68 (n)
  • 53.42 (a)
WDR66 36
  • 52 (a)
(Anolis carolinensis)
Reptilia WDR66 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr66 35
  • 58.1 (n)
  • 50.4 (a)
(Danio rerio)
Actinopterygii wdr66 35
  • 54.5 (n)
  • 45.36 (a)
wdr66 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007799 35
  • 43.49 (n)
  • 28.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for WDR66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR66 Gene

Gene Tree for WDR66 (if available)
Gene Tree for WDR66 (if available)

Paralogs for WDR66 Gene

No data available for Paralogs for WDR66 Gene

Variants for WDR66 Gene

Sequence variations from dbSNP and Humsavar for WDR66 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs493519 -- 121,959,570(+) CCAGC(C/T)TCTGT intron-variant
rs525664 -- 121,989,358(-) AGCAG(C/T)CAAGG intron-variant
rs529736 -- 121,946,551(-) taaaa(G/T)cagct intron-variant
rs567503 -- 121,972,187(-) cagtt(C/G)caaag downstream-variant-500B, intron-variant
rs657926 -- 121,971,480(+) TCCCA(A/C)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR66 Gene

Variant ID Type Subtype PubMed ID
nsv899568 CNV Gain 21882294
esv2659581 CNV Deletion 23128226

Variation tolerance for WDR66 Gene

Residual Variation Intolerance Score: 80.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.16; 99.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR66 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR66 Gene

Disorders for WDR66 Gene

Relevant External Links for WDR66

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR66: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR66 Gene

Publications for WDR66 Gene

  1. A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity. (PMID: 17967944) Dymek E.E. … Smith E.F. (J. Cell Biol. 2007) 2 67
  2. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 67
  3. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PMID: 24026423) Shameer K. … Kullo I.J. (Hum. Genet. 2014) 67
  4. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67
  5. Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma. (PMID: 23514407) Wang Q. … Kemmner W. (BMC Cancer 2013) 67

Products for WDR66 Gene

Sources for WDR66 Gene

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