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WDR66 Gene

protein-coding   GIFtS: 42
GCID: GC12P122356

WD Repeat Domain 66

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 661 2
WD Repeat-Containing Protein 662

External Ids:    HGNC: 285061   Entrez Gene: 1444062   Ensembl: ENSG000001580237   UniProtKB: Q8TBY93   

Export aliases for WDR66 gene to outside databases

Previous GC identifers: GC12P120820 GC12P119367


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR66 Gene:
This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the
formation of protein-protein complexes in a variety of biological pathways. This family member appears to
function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated
with variance in MPV. Alternative splicing of this gene results in multiple transcript variants. (provided by
RefSeq, Sep 2011)

GeneCards Summary for WDR66 Gene:
WDR66 (WD repeat domain 66) is a protein-coding gene. GO annotations related to this gene include calcium ion binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the WDR66 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT5A   Nkx2-5   STAT1alpha   STAT2   STAT3   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR66 promoter sequence
   Search Chromatin IP Primers for WDR66

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR66


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

WDR66 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR66 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P122356:  view genomic region     (about GC identifiers)

Start:
122,355,768 bp from pter      End:
122,441,833 bp from pter
Size:
86,066 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR66_HUMAN, Q8TBY9 (See protein sequence)
Recommended Name: WD repeat-containing protein 66  
Size: 1149 amino acids; 129952 Da
Secondary accessions: C9J1W2 Q8IYA3 Q8N898 Q8NDE7
Alternative splicing: 3 isoforms:  Q8TBY9-1   Q8TBY9-2   Q8TBY9-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR66: NX_Q8TBY9

Explore proteomics data for WDR66 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR66 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171474.1  NP_653269.3  

    ENSEMBL proteins: 
     ENSP00000288912   ENSP00000380595  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TBY9

    ProtoNet protein and cluster: Q8TBY9

    UniProtKB/Swiss-Prot: WDR66_HUMAN, Q8TBY9
    Similarity: Contains 9 WD repeats


    Find genes that share domains with WDR66           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR66           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR66:
     Decreased viability of wild-ty 

    Animal Models:
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR66
    Interactions:

        Search GeneGlobe Interaction Network for WDR66

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR66



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR66 gene (2 alternative transcripts): 
    NM_001178003.1  NM_144668.5  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000288912(uc009zxk.3) ENST00000397454(uc021rfh.1) ENST00000540779
    ENST00000546044 ENST00000543211 ENST00000535257 ENST00000545752 ENST00000428465
    ENST00000545988
    miRNA
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    hsa-miR-2113
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat WDR66

    Selected AceView cDNA sequences (see all 280):

    NM_002813 BQ060832 BC004184 BG676155 N57237 CR624376 BE466812 AA337357 
    AI580764 AL530953 BF510741 BC002383 AW627628 BI493839 BM823054 BM826633 
    AW242490 BG149414 BU740453 CB241016 BM981529 BU740504 BQ939922 BU738828 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR66 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCACTGCT
    WDR66 Expression
    About this image


    WDR66 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    WDR66 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR66 Protein Expression
        Custom PCR Arrays for WDR66
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR66

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR66 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr661 , 5 WD repeat domain 661, 5 79.8(n)1
    80.46(a)1
      5 (62.86 cM)5
    2697011  XM_006530515.11  XP_006530578.11 
     1232521025 
    chicken
    (Gallus gallus)
    Aves WDR661 WD repeat domain 66 60.68(n)
    53.42(a)
      416855  XM_415147.4  XP_415147.4 
    lizard
    (Anolis carolinensis)
    Reptilia WDR666
    WD repeat domain 66
    44(a)
    1 ↔ 1
    GL343550.1(342936-379511)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ082172.12   -- 73.89(n)    BJ082172.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr661 WD repeat domain 66 54.5(n)
    45.36(a)
      569257  XM_692631.5  XP_697723.4 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0077991 AgaP_AGAP007799 43.49(n)
    28.77(a)
      3291590  XM_555730.2  XP_555730.2 


    ENSEMBL Gene Tree for WDR66 (if available)
    TreeFam Gene Tree for WDR66 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR66 (see all 1898)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110432421,2
    C,F,H--122356293(+) GGGACG/CGGACC 2 -- us2k114Minor allele frequency- C:0.37NS EA NA WA CSA 765
    rs110432431,2
    C,F,A,H--122356370(+) CGACCG/CGCAGG 2 -- us2k110Minor allele frequency- C:0.25NS EA NA 536
    rs123013161,2
    C,F,H--122356386(+) CGTCGG/CGCACG 2 -- us2k17Minor allele frequency- C:0.04NS EA WA CSA 530
    rs107431851,2
    C,F,A,H--122356435(+) CTGTCA/GCTTTA 2 -- us2k17Minor allele frequency- G:0.43WA NA EA 368
    rs107431861,2
    C,F,A,H--122356436(+) TGTCGT/CTTTAG 2 -- us2k17Minor allele frequency- C:0.44NA WA EA 368
    rs752534291,2
    C,F--122356479(+) GGGGAC/TGGAGC 2 -- ut512Minor allele frequency- T:0.03NA EA 240
    rs1853107351,2
    --122356530(+) GCGGCC/TGCTGG 2 -- ut510--------
    rs1460893501,2
    --122356810(+) CTGCCC/GCAAAC 2 -- int10--------
    rs1891376471,2
    --122356913(+) AGCAGC/TGATTT 2 -- int10--------
    rs665394791,2
    C--122357027(+) TTTAT-/T/TTTA
            
    TTATT
    2 -- int11CSA 2

    HapMap Linkage Disequilibrium report for WDR66 (122355768 - 122441833 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WDR66:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659581CNV Deletion23128226
    nsv899568CNV Gain21882294

    Human Gene Mutation Database (HGMD): WDR66
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR66
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR66

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with WDR66           About GenesLikeMe

    Genetic Association Database (GAD): WDR66
    Human Genome Epidemiology (HuGE) Navigator: WDR66 (2 documents)

    Export disorders for WDR66 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR66 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with WDR66)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study of metabolic traits in human urine. (PubMed id 21572414)1, 4 Suhre K....Nauck M. (Nat. Genet. 2011)
    2. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    3. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    5. A genome-wide association study identifies three loci associated with mean platelet volume. (PubMed id 19110211)1, 4 Meisinger C....DAPring A. (Am. J. Hum. Genet. 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. (PubMed id 24026423)1 Shameer K....Kullo I.J. (Hum. Genet. 2014)
    9. Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma. (PubMed id 23514407)1 Wang Q....Kemmner W. (BMC Cancer 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144406 HGNC: 28506 AceView: PSMD9andMGC33630 Ensembl:ENSG00000158023 euGenes: HUgn144406
    ECgene: WDR66 H-InvDB: WDR66

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR66 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR66 gene:
    Search GeneIP for patents involving WDR66

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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