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WDR64 Gene(Protein Coding)

WD Repeat Domain 64

GCID:
GC01P241652
GIFtS:
42
Genes Participants
UDN Logo

Aliases for WDR64 Gene

Aliases for WDR64 Gene

  • WD Repeat Domain 64 2 3 5

External Ids for WDR64 Gene

Previous GeneCards Identifiers for WDR64 Gene

  • GC01P238173
  • GC01P239882
  • GC01P241815
  • GC01P212273

Summaries for WDR64 Gene

GeneCards Summary for WDR64 Gene

WDR64 (WD Repeat Domain 64) is a Protein Coding gene. An important paralog of this gene is EFCAB8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR64 Gene

Genomics for WDR64 Gene

Products:

  1. Regulatory Element

Regulatory Elements for WDR64 Gene

Enhancers for WDR64 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F241603 1.7 FANTOM5 Ensembl ENCODE 11.7 -43.8 -43783 10.5 PKNOX1 ATF1 ARNT ZFP64 SIN3A YBX1 YY1 ZNF766 GATA2 FOS KMO CHML WDR64 OPN3 GC01M241589 LOC105373233
GH01F241837 1 Ensembl ENCODE 10.6 +186.1 186125 1.9 STAT1 JUN CEBPB EP300 BRCA1 RFX5 JUND MAFF STAT3 RCOR1 WDR64 CHML GC01P241832 EXO1
GH01F241627 0.9 Ensembl ENCODE 11.6 -24.2 -24180 2.0 CTCF ZNF654 ZNF501 REST RAD21 JUND SCRT2 SMC3 SPI1 CHML WDR64 GC01M241629 GC01M241589
GH01F241918 0.7 Ensembl ENCODE 11 +266.9 266931 1.0 ATF3 ZIC2 WDR64 GC01P241917 BECN2
GH01F241828 0.5 Ensembl 12.1 +176.5 176523 0.4 ZFP3 CEBPB PRDM1 WDR64 RPL6P3 LOC105373231
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR64 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the WDR64 gene promoter:

Genomic Location for WDR64 Gene

Chromosome:
1
Start:
241,652,278 bp from pter
End:
241,802,745 bp from pter
Size:
150,468 bases
Orientation:
Plus strand

Genomic View for WDR64 Gene

Genes around WDR64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR64 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR64 Gene

Proteins for WDR64 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WDR64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1ANS9-WDR64_HUMAN
    Recommended name:
    WD repeat-containing protein 64
    Protein Accession:
    B1ANS9
    Secondary Accessions:
    • B1ANT0
    • Q7Z573
    • Q96LY9

    Protein attributes for WDR64 Gene

    Size:
    1081 amino acids
    Molecular mass:
    123631 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP92796.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71525.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR64 Gene

Protein Expression for WDR64 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR64 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR64 Gene

Domains & Families for WDR64 Gene

Gene Families for WDR64 Gene

HGNC:

Protein Domains for WDR64 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDR64 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

B1ANS9

UniProtKB/Swiss-Prot:

WDR64_HUMAN :
  • Contains 14 WD repeats.
Similarity:
  • Contains 14 WD repeats.
genes like me logo Genes that share domains with WDR64: view

Function for WDR64 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR64 Gene

Localization for WDR64 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR64 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR64 Gene

Pathways & Interactions for WDR64 Gene

SuperPathways for WDR64 Gene

PathCards logo More details on SuperPathways for WDR64
No Data Available

Interacting Proteins for WDR64 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355510%0d%0a9606.ENSP00000231487%0d%0a9606.ENSP00000326804%0d%0a9606.ENSP00000358147%0d%0a9606.ENSP00000358810%0d%0a9606.ENSP00000249344%0d%0a
Selected Interacting proteins: ENSP00000355510 for WDR64 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR64 Gene

Drugs & Compounds for WDR64 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WDR64 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for WDR64 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR64 Gene

WD repeat domain 64:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR64 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: - - - - - -

Relevant External Links for WDR64 Gene

GeneLoc Exon Structure for
WDR64
ECgene alternative splicing isoforms for
WDR64

Expression for WDR64 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR64 Gene

mRNA expression in normal human tissues for WDR64 Gene
mRNA expression by BioGPS for WDR64 GenemRNA expression by GTEx for WDR64 Gene

mRNA differential expression in normal tissues according to GTEx for WDR64 Gene

This gene is overexpressed in Testis (x35.8).

Protein differential expression in normal tissues from HIPED for WDR64 Gene

This gene is overexpressed in Lymph node (24.5), Plasma (8.8), and Fetal gut (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR64 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR64 Gene:

WDR64

SOURCE GeneReport for Unigene cluster for WDR64 Gene:

Hs.97527
genes like me logo Genes that share expression patterns with WDR64: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for WDR64 Gene

Orthologs for WDR64 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia WDR64 34 35
  • 99.2 (n)
cow
(Bos Taurus)
 Mammalia WDR64 34 35
  • 87.84 (n)
dog
(Canis familiaris)
 Mammalia WDR64 34
  • 87.33 (n)
-- 35
  • 81 (a)
 OneToMany
-- 35
  • 79 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Wdr64 34 16 35
  • 81.89 (n)
rat
(Rattus norvegicus)
 Mammalia Wdr64 34
  • 81.68 (n)
oppossum
(Monodelphis domestica)
 Mammalia WDR64 35
  • 65 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia WDR64 35
  • 18 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves WDR64 34 35
  • 62.66 (n)
lizard
(Anolis carolinensis)
 Reptilia WDR64 35
  • 53 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-1m11.8 35
  • 17 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG40583 35
  • 21 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 20 (a)
 ManyToMany
Species where no ortholog for WDR64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR64 Gene

ENSEMBL:
Gene Tree for WDR64 (if available)
TreeFam:
Gene Tree for WDR64 (if available)

Paralogs for WDR64 Gene

Paralogs for WDR64 Gene

genes like me logo Genes that share paralogs with WDR64: view

Variants for WDR64 Gene

Sequence variations from dbSNP and Humsavar for WDR64 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10047251 -- 241,751,103(+) CAGTT(A/G)CCAAA intron-variant
rs10157695 -- 241,752,568(+) TGTTG(A/G)gctgg intron-variant
rs10530068 -- 241,773,175(+) TCTCT(-/CT)TTTTG intron-variant, downstream-variant-500B
rs10536871 -- 241,739,971(+) GTCAC(-/TGT)TGTTA intron-variant
rs10612577 -- 241,716,651(+) AACAT(-/ATGATG)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR64 Gene

Variant ID Type Subtype PubMed ID
nsv549460 CNV gain 21841781
nsv528015 CNV gain 19592680
nsv1130987 CNV deletion 24896259
nsv1069424 CNV deletion 25765185
nsv1002214 CNV gain 25217958
esv3589351 CNV loss 21293372
esv3589350 CNV loss 21293372
esv3589349 CNV loss 21293372
esv3549554 CNV deletion 23714750
esv3339965 CNV insertion 20981092
esv3337219 CNV insertion 20981092
esv3307648 CNV mobile element insertion 20981092
esv2762521 CNV loss 21179565
esv2726252 CNV deletion 23290073
esv2726240 CNV deletion 23290073
esv2673784 CNV deletion 23128226
esv2661246 CNV deletion 23128226
esv2624301 CNV insertion 19546169

Variation tolerance for WDR64 Gene

Gene Damage Index Score: 9.09; 87.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR64 Gene

Human Gene Mutation Database (HGMD)
WDR64
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR64 Gene

Disorders for WDR64 Gene

Relevant External Links for WDR64

Genetic Association Database (GAD)
WDR64
Human Genome Epidemiology (HuGE) Navigator
WDR64
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR64

No disorders were found for WDR64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR64 Gene

Publications for WDR64 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PMID: 20923822) Niu N. … Wang L. (Genome Res. 2010) 3 46 64
  3. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley J.L. … Haines J.L. (Genes Immun. 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M. … Iacono W.G. (Behav. Genet. 2013) 3 64

Products for WDR64 Gene

Sources for WDR64 Gene

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