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Set Analyses:

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WDR64 Gene

protein-coding GIFtS: 43
GCID: GC01P241815

WD Repeat Domain 64

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
WD Repeat Domain 64¹ ²
WD Repeat-Containing Protein 64²

External Ids:	HGNC: 26570¹	Entrez Gene: 128025²	Ensembl: ENSG00000162843⁷	UniProtKB: B1ANS9³

Export aliases for WDR64 gene to outside databases

Previous GC identifers: GC01P238173 GC01P239882 GC01P212273

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for WDR64 Gene:

WDR64 (WD repeat domain 64) is a protein-coding gene. Diseases associated with WDR64 include multiple sclerosis. An important paralog of this gene is WDR49.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_167186.2 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the WDR64 gene promoter:
HTF POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) CUTL1 POU3F2 LCR-F1 GATA-2 C/EBPalpha Ik-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR64 promoter sequence

Search Chromatin IP Primers for WDR64

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR64

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q43 Ensembl cytogenetic band: 1q43 HGNC cytogenetic band: 1q43

WDR64 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR64 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P241815: view genomic region (about GC identifiers)

Start:	241,815,580 bp from pter	End:	241,965,435 bp from pter
Size:	149,856 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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UniProtKB/Swiss-Prot: WDR64_HUMAN, B1ANS9 (See protein sequence)

Recommended Name: WD repeat-containing protein 64

Size: 1081 amino acids; 123631 Da

Sequence caution: Sequence=AAP92796.1; Type=Erroneous initiation; Sequence=BAB71525.1; Type=Erroneous initiation;

Secondary accessions: B1ANT0 Q7Z573 Q96LY9

Alternative splicing: 2 isoforms: B1ANS9-1 B1ANS9-2

Explore the universe of human proteins at neXtProt for WDR64: NX_B1ANS9

Explore proteomics data for WDR64 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See WDR64 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653226.4

ENSEMBL proteins:

ENSP00000425552 ENSP00000406656 ENSP00000431729 ENSP00000406342 ENSP00000355510

ENSP00000402446

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

WDR: WD repeat domain containing

3 InterPro protein domains:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry B1ANS9

ProtoNet protein and cluster: B1ANS9

UniProtKB/Swiss-Prot: WDR64_HUMAN, B1ANS9

Similarity: Contains 12 WD repeats

WDR64 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

WDR64 for ontologies About GeneDecksing

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
nucleus	2
mitochondrion	1
peroxisome	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for WDR64
Interactions:

Search GeneGlobe Interaction Network for WDR64

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for WDR64 gene:

NM_144625.4

Unigene Cluster for WDR64:

WD repeat domain 64

Hs.97527 [show with all ESTs]

Unigene Representative Sequence: NM_144625

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000468967 ENST00000461971 ENST00000496914 ENST00000414635 ENST00000472717

ENST00000425826 ENST00000478331 ENST00000366552(uc001hzg.2) ENST00000437684(uc021plh.1 uc021pli.1)

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Additional mRNA sequence:

AK057540.1 AK122927.1 AY327404.1

5 DOTS entries:

DT.101979133 DT.101979134 DT.40277760 DT.205741 DT.95147648

13 AceView cDNA sequences:

AK122927 BE673668 NM_144625 BG150247 AA960789 AY327404 BE467936 AI001791

AI478745 AI457225 AK057540 BE045079 BU198831

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for WDR64 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22
SP1:																	-
SP2:																									-		-		-		-		-		-

ECgene alternative splicing isoforms for WDR64

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WDR64 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTATGTGTTG

About this image

WDR64 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

WDR64 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.97527

Custom PCR Arrays for WDR64

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for WDR64 gene from Selected species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wdr64^{1 , 5}	WD repeat domain 64^{1, 5}	81.89(n)¹ 80.8(a)¹		1 (81.71 cM)⁵ 75820¹ NM_029453.2¹ NP_083729.2¹ 175698593⁵
chicken (Gallus gallus)	Aves	WDR64¹	WD repeat domain 64	62.66(n) 51.26(a)		428581 XM_426138.4 XP_426138.4
lizard (Anolis carolinensis)	Reptilia	WDR64⁶	WD repeat domain 64	53(a)	1 ↔ 1	1(216374483-216425780)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-1m11.8⁶	si:dkey-1m11.8	17(a)	many ↔ many	15(30823777-30860512) ENSDARG00000054572
fruit fly (Drosophila melanogaster)	Insecta	CG40583⁶	--	21(a)	1 → many	U(4408205-4409285)

ENSEMBL Gene Tree for WDR64 (if available)
TreeFam Gene Tree for WDR64 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for WDR64 gene

WDR49² EFCAB8²

WDR64 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147996951^1,2	C	--	241813673(+)	`TTCTAC/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs192436390^1,2		--	241813762(+)	`TCAAAA/CACATC`	1	--	us2k¹		0	--	--	--	--
rs10802975^1,2	C,F,A,H	--	241813771(+)	`TCCCAC/TCTCAG`	1	--	us2k¹		30		NS EA NA WA CSA	2778
rs182488587^1,2	C	--	241813786(+)	`AAAGCC/GAAAGT`	1	--	us2k¹		0	--	--	--	--
rs143751849^1,2		--	241813790(+)	`CCAAA-/GTCCT AAAAC`	1	--	us2k¹		0	--	--	--	--
rs141736739^1,2	C	--	241813839(+)	`CCCTGA/GCTCTC`	1	--	us2k¹		0	--	--	--	--
rs72768052^1,2	C,F	--	241813854(+)	`CTTCTC/GTCTCT`	1	--	us2k¹		2		NA	122
rs7411883^1,2	C,F,A,H	--	241813906(+)	`tctgtC/Tgtttc`	1	--	us2k¹		13		EA NS WA NA CSA	664
rs72632896^1,2	C,F	--	241813913(+)	`TTTCTC/AAGATA`	1	--	us2k¹		3		WA NA EA	358
rs10802976^1,2	C,F,A,H	--	241814114(+)	`TTCCTC/GTCTCT`	1	--	us2k¹ trp³		15		NS EA NA WA CSA	791

HapMap Linkage Disequilibrium report for WDR64 (241815580 - 241965435 bp)

Structural Variations
Database of Genomic Variants (DGV) 10 variations for WDR64: About this table

Variant ID	Type	Subtype	PubMed ID
esv2661246	CNV	Deletion	23128226
esv2673784	CNV	Deletion	23128226
esv2726240	CNV	Deletion	23290073
esv2726252	CNV	Deletion	23290073
esv2624301	CNV	Insertion	19546169
esv271922	CNV	Insertion	20981092
nsv873368	CNV	Gain	21882294
nsv873373	CNV	Gain	21882294
nsv528015	CNV	Gain	19592680
nsv873372	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for WDR64:
About MalaCards

multiple sclerosis

WDR64 for disorders About GeneDecksing

Genetic Association Database (GAD): WDR64
Human Genome Epidemiology (HuGE) Navigator: WDR64 (2 documents)

Export disorders for WDR64 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for WDR64 gene integrated from 10 sources:
(articles sorted by number of sources associating them with WDR64)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)^{1, 4} Niu N....Wang L. (Genome Res. 2010)
Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PubMed id 19626040)^{1, 4} McCauley J.L....Haines J.L. (Genes Immun. 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)¹ McGue M....Iacono W.G. (Behav. Genet. 2013)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (Nature 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 128025	HGNC: 26570	AceView: FLJ32978	Ensembl:ENSG00000162843	euGenes: HUgn128025
ECgene: WDR64	H-InvDB: WDR64

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for WDR64	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR64 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WDR64 gene:
Search GeneIP for patents involving WDR64

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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Hot genes Disease genes WDR64 gene at Home site.

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WDR64 Gene

WD Repeat Domain 64

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WDR64 Gene

WD Repeat Domain 64

Aliasesfor WDR64 gene

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WDR64 Human Recombinant Protein Products:

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