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WDR64 Gene(Protein Coding)

WD Repeat Domain 64

GCID:
GC01P241652
GIFtS:
37
Genes Participants
UDN Logo

Aliases for WDR64 Gene

Aliases for WDR64 Gene

  • WD Repeat Domain 64 2 3 5

External Ids for WDR64 Gene

Previous GeneCards Identifiers for WDR64 Gene

  • GC01P238173
  • GC01P239882
  • GC01P241815
  • GC01P212273

Summaries for WDR64 Gene

GeneCards Summary for WDR64 Gene

WDR64 (WD Repeat Domain 64) is a Protein Coding gene. An important paralog of this gene is EFCAB8.

Additional gene information for WDR64 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR64 Gene

Genomics for WDR64 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for WDR64 Gene

Promoters and enhancers for WDR64 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I241652 Promoter 0.8 EPDnew 550.8 0.0 -16 0.1 ATF4 LEF1 CEBPB TRIM24 CEBPG WDR64 GC01P241649 OPN3
GH01I241653 Enhancer 0.6 ENCODE 550.8 +2.0 1989 0.9 HDAC1 LEF1 TAL1 CBFA2T3 DPF2 TCF12 MEF2D NCOR1 HDAC2 CBFA2T2 WDR64 OPN3 GC01P241649
GH01I241603 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -43.8 -43782 10.5 ATF1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A YBX1 YY1 TCF12 ARID2 KMO CHML WDR64 PLD5 OPN3 GC01M241589 LOC105373233
GH01I241627 Enhancer 0.8 Ensembl ENCODE 11.6 -24.2 -24180 2 CTCF ZNF654 REST ZNF501 RAD21 JUND SCRT2 SMC3 HNF4A FOSL2 CHML WDR64 GC01M241629 GC01M241589 OPN3
GH01I241918 Enhancer 0.6 Ensembl ENCODE 11 +266.9 266930 1 ATF4 ZIC2 WDR64 GC01P241917 BECN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR64 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR64 gene promoter:

Genomic Locations for WDR64 Gene

Genomic Locations for WDR64 Gene
chr1:241,652,278-241,802,745
(GRCh38/hg38)
Size:
150,468 bases
Orientation:
Plus strand
chr1:241,815,580-241,965,435
(GRCh37/hg19)

Genomic View for WDR64 Gene

Genes around WDR64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR64 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for WDR64 Gene

Proteins for WDR64 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for WDR64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B1ANS9-WDR64_HUMAN
    Recommended name:
    WD repeat-containing protein 64
    Protein Accession:
    B1ANS9
    Secondary Accessions:
    • B1ANT0
    • Q7Z573
    • Q96LY9

    Protein attributes for WDR64 Gene

    Size:
    1081 amino acids
    Molecular mass:
    123631 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP92796.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71525.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR64 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR64 Gene

Protein Expression for WDR64 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for WDR64 Gene

No Post-translational modifications

Other Protein References for WDR64 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR64 Gene

Domains & Families for WDR64 Gene

Gene Families for WDR64 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR64 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for WDR64 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR64: view

No data available for UniProtKB/Swiss-Prot for WDR64 Gene

Function for WDR64 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for WDR64 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR64 Gene

Localization for WDR64 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR64 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR64 Gene

Pathways & Interactions for WDR64 Gene

SuperPathways for WDR64 Gene

PathCards logo More details on SuperPathways for WDR64
No Data Available

Interacting Proteins for WDR64 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000355510%0d%0a9606.ENSP00000231487%0d%0a9606.ENSP00000324806%0d%0a9606.ENSP00000470087%0d%0a9606.ENSP00000222330%0d%0a9606.ENSP00000355031%0d%0a
Selected Interacting proteins: ENSP00000355510 for WDR64 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR64 Gene

Drugs & Compounds for WDR64 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for WDR64 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for WDR64 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR64 Gene

WD repeat domain 64:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR64 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: - - - - - -

Relevant External Links for WDR64 Gene

GeneLoc Exon Structure for
WDR64
ECgene alternative splicing isoforms for
WDR64

Expression for WDR64 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR64 Gene

mRNA expression in normal human tissues for WDR64 Gene
mRNA expression by BioGPS for WDR64 GenemRNA expression by GTEx for WDR64 Gene

mRNA differential expression in normal tissues according to GTEx for WDR64 Gene

This gene is overexpressed in Testis (x35.8).

Protein differential expression in normal tissues from HIPED for WDR64 Gene

This gene is overexpressed in Lymph node (24.5), Plasma (8.8), and Fetal gut (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR64 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR64 Gene:

WDR64

SOURCE GeneReport for Unigene cluster for WDR64 Gene:

Hs.97527
genes like me logo Genes that share expression patterns with WDR64: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR64 Gene

Orthologs for WDR64 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR64 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia WDR64 33 34
  • 99.2 (n)
cow
(Bos Taurus)
 Mammalia WDR64 33 34
  • 87.84 (n)
dog
(Canis familiaris)
 Mammalia WDR64 33
  • 87.33 (n)
-- 34
  • 81 (a)
 OneToMany
-- 34
  • 79 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Wdr64 33 16 34
  • 81.89 (n)
rat
(Rattus norvegicus)
 Mammalia Wdr64 33
  • 81.68 (n)
oppossum
(Monodelphis domestica)
 Mammalia WDR64 34
  • 65 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia WDR64 34
  • 18 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves WDR64 33 34
  • 62.66 (n)
lizard
(Anolis carolinensis)
 Reptilia WDR64 34
  • 53 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii si:dkey-1m11.8 34
  • 17 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG40583 34
  • 21 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 20 (a)
 ManyToMany
Species where no ortholog for WDR64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR64 Gene

ENSEMBL:
Gene Tree for WDR64 (if available)
TreeFam:
Gene Tree for WDR64 (if available)

Paralogs for WDR64 Gene

Paralogs for WDR64 Gene

genes like me logo Genes that share paralogs with WDR64: view

Variants for WDR64 Gene

Sequence variations from dbSNP and Humsavar for WDR64 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000009151 -- 241,770,030(+) G/A intron_variant
rs1000014180 -- 241,727,587(+) T/G intron_variant
rs1000035176 -- 241,681,142(+) T/C intron_variant
rs1000066395 -- 241,727,310(+) T/C intron_variant
rs1000093510 -- 241,693,085(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR64 Gene

Variant ID Type Subtype PubMed ID
esv2624301 CNV insertion 19546169
esv2661246 CNV deletion 23128226
esv2673784 CNV deletion 23128226
esv2726240 CNV deletion 23290073
esv2726252 CNV deletion 23290073
esv2762521 CNV loss 21179565
esv3307648 CNV mobile element insertion 20981092
esv3337219 CNV insertion 20981092
esv3339965 CNV insertion 20981092
esv3549554 CNV deletion 23714750
esv3589349 CNV loss 21293372
esv3589350 CNV loss 21293372
esv3589351 CNV loss 21293372
nsv1002214 CNV gain 25217958
nsv1069424 CNV deletion 25765185
nsv1130987 CNV deletion 24896259
nsv528015 CNV gain 19592680
nsv549460 CNV gain 21841781

Variation tolerance for WDR64 Gene

Gene Damage Index Score: 9.09; 87.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR64 Gene

Human Gene Mutation Database (HGMD)
WDR64
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR64

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR64 Gene

Disorders for WDR64 Gene

Additional Disease Information for WDR64

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR64 Gene

Publications for WDR64 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PMID: 20923822) Niu N … Wang L (Genome research 2010) 3 44 58
  3. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PMID: 19626040) McCauley JL … Haines JL (Genes and immunity 2009) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. A genome-wide association study of behavioral disinhibition. (PMID: 23942779) McGue M … Iacono WG (Behavior genetics 2013) 3 58

Products for WDR64 Gene

Sources for WDR64 Gene

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