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Aliases for WDR63 Gene

Aliases for WDR63 Gene

  • WD Repeat Domain 63 2 3
  • Testis Development Protein NYD-SP29 (NYD-SP29) 3
  • Testis Development Protein NYD-SP29 4
  • WD Repeat-Containing Protein 63 3
  • NYD-SP29 3
  • DIC3 3

External Ids for WDR63 Gene

Summaries for WDR63 Gene

GeneCards Summary for WDR63 Gene

WDR63 (WD Repeat Domain 63) is a Protein Coding gene. An important paralog of this gene is DNAI2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR63 Gene

Genomics for WDR63 Gene

Genomic Location for WDR63 Gene

Start:
84,999,147 bp from pter
End:
85,133,138 bp from pter
Size:
133,992 bases
Orientation:
Plus strand

Genomic View for WDR63 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR63 Gene

Regulatory Elements for WDR63 Gene

Proteins for WDR63 Gene

  • Protein details for WDR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWG1-WDR63_HUMAN
    Recommended name:
    WD repeat-containing protein 63
    Protein Accession:
    Q8IWG1
    Secondary Accessions:
    • A8K988
    • Q96L72
    • Q96NU4

    Protein attributes for WDR63 Gene

    Size:
    891 amino acids
    Molecular mass:
    102935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR63 Gene

Proteomics data for WDR63 Gene at MOPED

Post-translational modifications for WDR63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR63 Gene

No data available for DME Specific Peptides for WDR63 Gene

Domains for WDR63 Gene

Gene Families for WDR63 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR63 Gene

UniProtKB/Swiss-Prot:

WDR63_HUMAN
Similarity:
  • Contains 5 WD repeats.:
    • Q8IWG1
genes like me logo Genes that share domains with WDR63: view

Function for WDR63 Gene

Gene Ontology (GO) - Molecular Function for WDR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR63: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for WDR63 Gene

Localization for WDR63 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR63 Gene COMPARTMENTS Subcellular localization image for WDR63 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for WDR63 Gene

Pathways for WDR63 Gene

SuperPathways for WDR63 Gene

No Data Available

Interacting Proteins for WDR63 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000294664%0d%0a9606.ENSP00000248566%0d%0a9606.ENSP00000248566%0d%0a
Selected Interacting proteins: ENSP00000294664 for WDR63 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR63 Gene

None

No data available for Pathways by source for WDR63 Gene

Transcripts for WDR63 Gene

mRNA/cDNA for WDR63 Gene

Unigene Clusters for WDR63 Gene

WD repeat domain 63:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR63 Gene

No ASD Table

Relevant External Links for WDR63 Gene

GeneLoc Exon Structure for
WDR63
ECgene alternative splicing isoforms for
WDR63

Expression for WDR63 Gene

mRNA expression in normal human tissues for WDR63 Gene

mRNA differential expression in normal tissues according to GTEx for WDR63 Gene

This gene is overexpressed in Adrenal Gland (13.0) and Testis (12.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WDR63 Gene

SOURCE GeneReport for Unigene cluster for WDR63 Gene Hs.97933

genes like me logo Genes that share expressions with WDR63: view

Orthologs for WDR63 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR63 36
  • 99.4 (n)
  • 99.21 (a)
WDR63 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR63 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR63 36
  • 87.48 (n)
  • 85.94 (a)
WDR63 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr63 36
  • 79.82 (n)
  • 81.51 (a)
Wdr63 16
Wdr63 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR63 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR63 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr63 36
  • 80.52 (n)
  • 81.46 (a)
chicken
(Gallus gallus)
Aves WDR63 36
  • 65.2 (n)
  • 55.24 (a)
WDR63 37
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR63 37
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr63 36
  • 64.67 (n)
  • 58.59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12489 36
zebrafish
(Danio rerio)
Actinopterygii LOC100333131 36
  • 54.62 (n)
  • 45.5 (a)
WDR63 37
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009027 36
  • 40.92 (n)
  • 26.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14838 36
  • 43.56 (n)
  • 27.45 (a)
CG14838 37
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToOne
Species with no ortholog for WDR63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR63 Gene

ENSEMBL:
Gene Tree for WDR63 (if available)
TreeFam:
Gene Tree for WDR63 (if available)

Paralogs for WDR63 Gene

Paralogs for WDR63 Gene

Selected SIMAP similar genes for WDR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR63: view

Variants for WDR63 Gene

Sequence variations from dbSNP and Humsavar for WDR63 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs709759 -- 85,108,338(+) GATTG(A/G)GAGGA intron-variant
rs709760 -- 85,109,065(-) TTTCC(A/G)TGGTC intron-variant
rs709761 -- 85,083,791(+) TTCTT(C/T)ACTCC intron-variant
rs709762 -- 85,093,769(-) CCTAG(C/T)GAGTA intron-variant
rs709763 -- 85,094,239(+) accag(C/G)cagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR63 Gene

Variant ID Type Subtype PubMed ID
nsv470724 CNV Gain 18288195
nsv462383 CNV Gain 19166990
nsv521770 CNV Loss 19592680
nsv523150 CNV Loss 19592680
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897

Relevant External Links for WDR63 Gene

HapMap Linkage Disequilibrium report
WDR63

Disorders for WDR63 Gene

Relevant External Links for WDR63

Genetic Association Database (GAD)
WDR63
Human Genome Epidemiology (HuGE) Navigator
WDR63
genes like me logo Genes that share disorders with WDR63: view

No data available for UniProtKB/Swiss-Prot for WDR63 Gene

Publications for WDR63 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WDR63 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate WDR63
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for WDR63
    • Block miRNA regulation of WDR63 using miScript Target Protectors

    Sources for WDR63 Gene

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