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Aliases for WDR63 Gene

Aliases for WDR63 Gene

  • WD Repeat Domain 63 2 3 5
  • Testis Development Protein NYD-SP29 (NYD-SP29) 3
  • Testis Development Protein NYD-SP29 4
  • Testicular Tissue Protein Li 225 3
  • WD Repeat-Containing Protein 63 3
  • NYD-SP29 3
  • DIC3 3

External Ids for WDR63 Gene

Previous GeneCards Identifiers for WDR63 Gene

  • GC01P085177
  • GC01P085300
  • GC01P085464
  • GC01P083637

Summaries for WDR63 Gene

GeneCards Summary for WDR63 Gene

WDR63 (WD Repeat Domain 63) is a Protein Coding gene. Diseases associated with WDR63 include Hemometra. An important paralog of this gene is WDR78.

Additional gene information for WDR63 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR63 Gene

Genomics for WDR63 Gene

GeneHancer (GH) Regulatory Elements for WDR63 Gene

Promoters and enhancers for WDR63 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I085061 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 558 +63.1 63105 1.5 PKNOX1 ATF1 SIN3A BMI1 ZNF2 RFX5 ZNF335 GLIS2 ZNF366 FOS WDR63 MCOLN2 MCOLN3 MIR4423
GH01I084997 Enhancer 0.5 ENCODE 550.8 -0.4 -398 1.5 SMARCA5 ZNF121 POLR2A SUZ12 NFATC1 NRF1 EZH2 MCOLN2 WDR63
GH01I084971 Enhancer 0.7 ENCODE 12.6 -26.3 -26311 2.4 HDGF FEZF1 RELA FOXM1 ZFHX2 NFATC1 IKZF2 RUNX3 TCF7L2 ZNF687 MCOLN2 WDR63 LPAR3
GH01I085047 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.4 +49.8 49802 3.1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF213 KLF7 SP3 REST TSHZ1 MCOLN3 ENSG00000271576 MCOLN2 ZNHIT6 WDR63 MIR4423
GH01I084968 Enhancer 0.7 ENCODE 12.2 -29.4 -29443 1.8 SMAD1 PAX8 EBF1 BATF KLF5 IRF4 RELA ATF7 ETV6 IKZF2 MCOLN2 MCOLN3 WDR63 LPAR3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR63 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR63 gene promoter:

Genomic Locations for WDR63 Gene

Genomic Locations for WDR63 Gene
chr1:84,999,147-85,133,138
(GRCh38/hg38)
Size:
133,992 bases
Orientation:
Plus strand
chr1:85,464,830-85,598,821
(GRCh37/hg19)

Genomic View for WDR63 Gene

Genes around WDR63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR63 Gene

Proteins for WDR63 Gene

  • Protein details for WDR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWG1-WDR63_HUMAN
    Recommended name:
    WD repeat-containing protein 63
    Protein Accession:
    Q8IWG1
    Secondary Accessions:
    • A8K988
    • Q96L72
    • Q96NU4

    Protein attributes for WDR63 Gene

    Size:
    891 amino acids
    Molecular mass:
    102935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR63 Gene

Post-translational modifications for WDR63 Gene

No Post-translational modifications

Other Protein References for WDR63 Gene

No data available for DME Specific Peptides for WDR63 Gene

Domains & Families for WDR63 Gene

Gene Families for WDR63 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for WDR63 Gene

Suggested Antigen Peptide Sequences for WDR63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR63: view

No data available for UniProtKB/Swiss-Prot for WDR63 Gene

Function for WDR63 Gene

Phenotypes From GWAS Catalog for WDR63 Gene

Gene Ontology (GO) - Molecular Function for WDR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008574 contributes_to ATP-dependent microtubule motor activity, plus-end-directed IBA --
GO:0045503 dynein light chain binding IBA --
GO:0045504 dynein heavy chain binding IBA --
genes like me logo Genes that share ontologies with WDR63: view

Phenotypes for WDR63 Gene

genes like me logo Genes that share phenotypes with WDR63: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR63 Gene

Localization for WDR63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR63 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for WDR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030286 dynein complex IBA --
genes like me logo Genes that share ontologies with WDR63: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for WDR63 Gene

Pathways & Interactions for WDR63 Gene

SuperPathways for WDR63 Gene

No Data Available

Interacting Proteins for WDR63 Gene

Selected Interacting proteins: Q8IWG1-WDR63_HUMAN for WDR63 Gene via IID

Symbol External ID(s) Details
ATP6V1B2
SEM1

Gene Ontology (GO) - Biological Process for WDR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IBA --
genes like me logo Genes that share ontologies with WDR63: view

No data available for Pathways by source and SIGNOR curated interactions for WDR63 Gene

Drugs & Compounds for WDR63 Gene

No Compound Related Data Available

Transcripts for WDR63 Gene

Unigene Clusters for WDR63 Gene

WD repeat domain 63:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR63 Gene

No ASD Table

Relevant External Links for WDR63 Gene

GeneLoc Exon Structure for
WDR63
ECgene alternative splicing isoforms for
WDR63

Expression for WDR63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR63 Gene

mRNA differential expression in normal tissues according to GTEx for WDR63 Gene

This gene is overexpressed in Adrenal Gland (x13.0) and Testis (x12.8).

Protein differential expression in normal tissues from HIPED for WDR63 Gene

This gene is overexpressed in Cerebrospinal fluid (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR63 Gene



Protein tissue co-expression partners for WDR63 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR63 Gene:

WDR63

SOURCE GeneReport for Unigene cluster for WDR63 Gene:

Hs.97933

Evidence on tissue expression from TISSUES for WDR63 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with WDR63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR63 Gene

Orthologs for WDR63 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR63 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia WDR63 33 34
  • 87.48 (n)
cow
(Bos Taurus)
Mammalia WDR63 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr63 33
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Wdr63 33 16 34
  • 79.82 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR63 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR63 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR63 33 34
  • 65.2 (n)
lizard
(Anolis carolinensis)
Reptilia WDR63 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr63 33
  • 64.67 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100333131 33
  • 54.62 (n)
WDR63 34
  • 44 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12489 33
fruit fly
(Drosophila melanogaster)
Insecta CG14838 33 34
  • 43.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009027 33
  • 40.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for WDR63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR63 Gene

ENSEMBL:
Gene Tree for WDR63 (if available)
TreeFam:
Gene Tree for WDR63 (if available)

Paralogs for WDR63 Gene

Paralogs for WDR63 Gene

(1) SIMAP similar genes for WDR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR63: view

Variants for WDR63 Gene

Sequence variations from dbSNP and Humsavar for WDR63 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028420 -- 85,113,522(+) G/T intron_variant
rs1000050456 -- 85,109,930(+) A/G/T intron_variant
rs1000064336 -- 85,104,670(+) G/T intron_variant
rs1000076313 -- 85,078,262(+) C/T intron_variant
rs1000080404 -- 85,113,109(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR63 Gene

Variant ID Type Subtype PubMed ID
esv2763574 CNV loss 21179565
esv34165 CNV loss 18971310
esv3586676 CNV gain 21293372
esv3586677 CNV loss 21293372
nsv462383 CNV gain 19166990
nsv470724 CNV gain 18288195
nsv521770 CNV loss 19592680
nsv523150 CNV loss 19592680
nsv546700 CNV gain 21841781
nsv830459 CNV loss 17160897
nsv947434 CNV duplication 23825009

Variation tolerance for WDR63 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR63 Gene

Disorders for WDR63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR63 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hemometra
  • hematometra
- elite association - COSMIC cancer census association via MalaCards
Search WDR63 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WDR63

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WDR63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR63 Gene

Publications for WDR63 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom EF … King SM (Cytoskeleton (Hoboken, N.J.) 2011) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for WDR63 Gene

Sources for WDR63 Gene

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