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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR63 Gene

protein-coding   GIFtS: 43
GCID: GC01P085464

WD Repeat Domain 63

  Search for WDR63
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 631 2     Testis Development Protein NYD-SP29 (NYD-SP29)2
DIC32     WD Repeat-Containing Protein 632
NYD-SP292     Testis Development Protein NYD-SP293
RP11-507C22.22     

External Ids:    HGNC: 307111   Entrez Gene: 1268202   Ensembl: ENSG000001626437   UniProtKB: Q8IWG13   

Export aliases for WDR63 gene to outside databases

Previous GC identifers: GC01P085177 GC01P085300 GC01P083637


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR63 Gene: 
WDR63 (WD repeat domain 63) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR63 gene promoter:
         RFX1   Sox5   Bach2   Pax-2   POU6F1 (c2)   Pax-2a   LCR-F1   AP-2gamma   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR63 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR63

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22.3

WDR63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR63 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P085464:  view genomic region     (about GC identifiers)

Start:
85,464,830 bp from pter      End:
85,598,821 bp from pter
Size:
133,992 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR63_HUMAN, Q8IWG1 (See protein sequence)
Recommended Name: WD repeat-containing protein 63  
Size: 891 amino acids; 102935 Da
Secondary accessions: A8K988 Q96L72 Q96NU4
Alternative splicing: 2 isoforms:  Q8IWG1-1   Q8IWG1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR63: NX_Q8IWG1

Explore proteomics data for WDR63 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWG1

  • WDR63 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR63 Protein Expression
    REFSEQ proteins: NP_660155.2  
    ENSEMBL proteins: 
     ENSP00000359628   ENSP00000317463   ENSP00000294664   ENSP00000435102   ENSP00000433294  
     ENSP00000435544  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IWG1

    ProtoNet protein and cluster: Q8IWG1

    UniProtKB/Swiss-Prot: WDR63_HUMAN, Q8IWG1
    Similarity: Contains 5 WD repeats


    WDR63 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR63 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for WDR63 (ENSP000002946644) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C10orf107ENSP000003286984STRING: ENSP00000328698
    ENSG00000206284ENSP000003726954STRING: ENSP00000372695
    ENSG00000224496ENSP000003896074STRING: ENSP00000389607
    ENSG00000225130ENSP000003916854STRING: ENSP00000391685
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR63

    Search CenterWatch for drugs/clinical trials and news about WDR63

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR63 gene: 
    NM_145172.3  

    Unigene Cluster for WDR63:

    WD repeat domain 63
    Hs.97933  [show with all ESTs]
    Unigene Representative Sequence: BX648851
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370596 ENST00000326813(uc009wcl.3) ENST00000294664(uc001dkt.3)
    ENST00000528899 ENST00000464801 ENST00000484007
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of WDR63 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR63

    Additional mRNA sequence: 

    AK054629.1 AK292603.1 AY049724.1 BC040265.1 BX648851.1 

    3 DOTS entries:

    DT.100018688  DT.40119206  DT.101966699 

    20 AceView cDNA sequences:

    BC040265 AK054629 BI828034 AY049724 CD243488 AA405514 BX648851 AL709173 
    NM_145172 AI287280 BG718191 AI860874 BG718321 AW167107 CB999565 BF980375 
    BU561605 CD696058 CD695998 BE567441 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR63 expression in normal human tissues (normalized intensities)      WDR63 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAACATAT
    WDR63 Expression
    About this image


    WDR63 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)

    See WDR63 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR63

    SOURCE GeneReport for Unigene cluster: Hs.97933
        SABiosciences Custom PCR Arrays for WDR63
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR63

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDR63 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr631 , 5 WD repeat domain 631, 5 79.82(n)1
    81.51(a)1
      3 (71.03 cM)5
    2422531  NM_172864.31  NP_766452.21 
     1460405265 
    chicken
    (Gallus gallus)
    Aves WDR631 WD repeat domain 63 66.24(n)
    56.87(a)
      429090  XM_426646.3  XP_426646.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR636
    Uncharacterized protein
    55(a)
    1 ↔ 1
    GL343194.1(10114151-10166713)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ083078.12   -- 74.87(n)    BJ083078.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000011871 WD repeat-containing protein 63-like 53.91(n)
    46.68(a)
      100001187  XM_001341205.4  XP_001341241.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG148381 CG14838 41.76(n)
    25.68(a)
      38851  NM_139881.2  NP_648138.1 


    ENSEMBL Gene Tree for WDR63 (if available)
    TreeFam Gene Tree for WDR63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR63 gene
    1 SIMAP similar gene for WDR63 using alignment to 5 protein entries:     WDR63_HUMAN (see all proteins):
    DNAI2

    WDR63 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1490 SNPs in WDR63 are shown (see all 1490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923288061,2
    --85526017(+) GGAAAC/GAGATA 1 -- us2k10--------
    rs1170474691,2
    F--85526025(+) ATAGAA/GCAAGT 1 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1846602421,2
    --85526088(+) GCAGAA/GGCAGA 1 -- us2k10--------
    rs1387680351,2
    --85526455(+) TGTTAA/GGCTGA 1 -- us2k10--------
    rs66779691,2
    C,F,A,H--85526530(+) gccgaC/Tgccac 1 -- us2k15Minor allele frequency- T:0.03NS EA WA 536
    rs66779801,2
    C,F,A,H--85526556(+) agtgaC/Gaaaag 1 -- us2k19Minor allele frequency- G:0.02NS EA NA WA 1274
    rs66781891,2
    C,F--85526742(+) AGAATC/TTATAT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1891229051,2
    --85526765(+) CATAAA/CGTAAA 1 -- us2k10--------
    rs173715261,2
    C,F,H--85526773(+) AAAAAT/CCTTCA 1 -- us2k126Minor allele frequency- C:0.19NA NS EA CSA WA 2904
    rs781514521,2
    C,F--85526779(+) CTTCAT/CTCAGG 1 -- us2k11Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for WDR63 (85464830 - 85598821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for WDR63:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830459CNV Loss17160897
    esv34165CNV Loss18971310
    nsv521770CNV Loss19592680
    nsv523150CNV Loss19592680
    nsv470724CNV Gain18288195
    nsv462383CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDR63 for disorders           About MalaCards

    WDR63 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR63
    Human Genome Epidemiology (HuGE) Navigator: WDR63 (1 document)

    Export disorders for WDR63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR63 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PubMed id 23509962)1 Greliche N....Tregouet D.A. (2013)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 126820 HGNC: 30711 AceView: NYD-SP29 Ensembl:ENSG00000162643 euGenes: HUgn126820
    ECgene: WDR63 H-InvDB: WDR63

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR63 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR63 gene:
    Search GeneIP for patents involving WDR63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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