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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDR63 Gene

protein-coding GIFtS: 43
GCID: GC01P085464

WD repeat domain 63

Explore 1 disease affiliated with
WDR63 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD Repeat Domain 63¹ ²		RP11-507C22.2²
DIC3¹ ²		Testis Development Protein NYD-SP29 (NYD-SP29)²
NYD-SP29¹ ²		WD Repeat-Containing Protein 63²
FLJ30067¹		Testis Development Protein NYD-SP29³

External Ids:	HGNC: 30711¹	Entrez Gene: 126820²	Ensembl: ENSG00000162643⁷	UniProtKB: Q8IWG1³

Export aliases for WDR63 gene to outside databases

Previous GC identifers: GC01P085177 GC01P085300 GC01P083637

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WDR63 gene promoter:
RFX1 Sox5 Bach2 Pax-2 POU6F1 (c2) Pax-2a LCR-F1 AP-2gamma Pax-2b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR63 promoter sequence

Search SABiosciences Chromatin IP Primers for WDR63

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR63

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.3 Ensembl cytogenetic band: 1p22.3 HGNC cytogenetic band: 1p22.3

WDR63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR63 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P085464: view genomic region (about GC identifiers)

Start:	85,464,830 bp from pter	End:	85,598,821 bp from pter
Size:	133,992 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR63_HUMAN, Q8IWG1 (See protein sequence)

Recommended Name: WD repeat-containing protein 63

Size: 891 amino acids; 102935 Da

Secondary accessions: A8K988 Q96L72 Q96NU4

Alternative splicing: 2 isoforms: Q8IWG1-1 Q8IWG1-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR63: NX_Q8IWG1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IWG1

WDR63 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_660155.2

ENSEMBL proteins:

ENSP00000359628 ENSP00000317463 ENSP00000294664 ENSP00000435102 ENSP00000433294

ENSP00000435544

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR63 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q8IWG1

ProtoNet protein and cluster: Q8IWG1

UniProtKB/Swiss-Prot: WDR63_HUMAN, Q8IWG1

Similarity: Contains 5 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for WDR63

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WDR63

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

5/13 Interacting proteins for WDR63 (ENSP00000294664⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C10orf107	ENSP00000328698⁴	STRING: ENSP00000328698
HSD3B1	ENSP00000358421⁴	STRING: ENSP00000358421
HYI	ENSP00000361507⁴	STRING: ENSP00000361507
PRUNE	ENSP00000271620⁴	STRING: ENSP00000271620
TPRG1L	ENSP00000367595⁴	STRING: ENSP00000367595

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDR63
Search CenterWatch for drugs/clinical trials and news about WDR63

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for WDR63 gene:

NM_145172.3

Unigene Cluster for WDR63:

WD repeat domain 63

Hs.97933 [show with all ESTs]

Unigene Representative Sequence: BX648851

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000370596 ENST00000326813(uc009wcl.3) ENST00000294664(uc001dkt.3)

ENST00000528899 ENST00000464801 ENST00000484007

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Additional cDNA sequence:

AK054629.1 AK292603.1 AY049724.1 BC040265.1 BX648851.1

3 DOTS entries:

DT.100018688 DT.40119206 DT.101966699

20 AceView cDNA sequences:

BC040265 AK054629 BI828034 AL709173 AI860874 BG718191 AI287280 NM_145172

AY049724 BX648851 AA405514 CD243488 BG718321 BF980375 BU561605 CB999565

AW167107 CD696058 CD695998 BE567441

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR63 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAACATAT

About this image

WDR63 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WDR63 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR63

SOURCE GeneReport for Unigene cluster: Hs.97933

SABiosciences Custom PCR Arrays for WDR63

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for WDR63 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wdr63^{1 , 5}	WD repeat domain 63^{1, 5}	79.82(n)¹ 81.51(a)¹		3 (71.03 cM)⁵ 242253¹ NM_172864.3¹ NP_766452.2¹ 146040526⁵
chicken (Gallus gallus)	Aves	WDR63¹	WD repeat domain 63	66.24(n) 56.87(a)		429090 XM_426646.3 XP_426646.3
lizard (Anolis carolinensis)	Reptilia	WDR63⁶	--	57(a)	1 ↔ 1	GL343194.1(10138560-10166379)
African clawed frog (Xenopus laevis)	Amphibia	BJ083078.1²	--	74.87(n)		BJ083078.1
zebrafish (Danio rerio)	Actinopterygii	LOC100001187¹	WD repeat-containing protein 63-like	53.91(n) 46.68(a)		100001187 XM_001341205.4 XP_001341241.4
fruit fly (Drosophila melanogaster)	Insecta	CG14838¹	CG14838	41.76(n) 25.68(a)		38851 NM_139881.2 NP_648138.1

ENSEMBL Gene Tree for WDR63 (if available)
TreeFam Gene Tree for WDR63 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WDR63 gene

DNAI2² DYNC1I1² WDR34² DNAI1² DYNC1I2² WDR78²

1 SIMAP similar gene for WDR63 using alignment to 5 protein entries: WDR63_HUMAN (see all proteins):

DNAI2

WDR63 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66689432^1,2	C	--	83680224(+)	`CATAG-/TTCTTCTT`	1	--	int¹		0	--	--	--	--
rs199612763^1,2	C	--	83699977(+)	`GTAAGG/TTNNNN`	1	--	int¹		0	--	--	--	--
rs192328806^1,2		--	85526017(+)	`GGAAAC/GAGATA`	1	--	us2k¹		0	--	--	--	--
rs117047469^1,2	F	--	85526025(+)	`ATAGAA/GCAAGT`	1	--	us2k¹		1		EA	120
rs184660242^1,2		--	85526088(+)	`GCAGAA/GGCAGA`	1	--	us2k¹		0	--	--	--	--
rs138768035^1,2		--	85526455(+)	`TGTTAA/GGCTGA`	1	--	us2k¹		0	--	--	--	--
rs6677969^1,2	C,F,A,H	--	85526530(+)	`GCCGAC/TGCCAC`	1	--	us2k¹		5		NS EA WA	536
rs6677980^1,2	C,F,A,H	--	85526556(+)	`agtgaC/Gaaaag`	1	--	us2k¹		9		NS EA NA WA	1274
rs6678189^1,2	C,F	--	85526742(+)	`AGAATC/TTATAT`	1	--	us2k¹		1		WA	118
rs189122905^1,2		--	85526765(+)	`CATAAA/CGTAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WDR63 (85464830 - 85598821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR63
1 CNV: 47846

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WDR63 for disorders About GeneDecksing

1 disease for WDR63: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: WDR63 (1 document)

Export disorders for WDR63 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR63 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR63)

Utopia: connect your pdf to the dynamic
world of online information

A unified taxonomy for ciliary dyneins. (PubMed id 21953912)^{1, 3} Hom E.F....King S.M. (2011)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 126820	HGNC: 30711	AceView: NYD-SP29	Ensembl:ENSG00000162643	euGenes: HUgn126820
ECgene: WDR63	H-InvDB: WDR63

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR63	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR63 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR63 gene:
Search GeneIP for patents involving WDR63

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR63

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WDR63 gene at Home site.

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WDR63 Gene

WD repeat domain 63

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WDR63 Gene

WD repeat domain 63

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