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Aliases for WDR63 Gene

Aliases for WDR63 Gene

  • WD Repeat Domain 63 2 3 5
  • Testis Development Protein NYD-SP29 (NYD-SP29) 3
  • Testis Development Protein NYD-SP29 4
  • Testicular Tissue Protein Li 225 3
  • WD Repeat-Containing Protein 63 3
  • NYD-SP29 3
  • DIC3 3

External Ids for WDR63 Gene

Previous GeneCards Identifiers for WDR63 Gene

  • GC01P085177
  • GC01P085300
  • GC01P085464
  • GC01P083637

Summaries for WDR63 Gene

GeneCards Summary for WDR63 Gene

WDR63 (WD Repeat Domain 63) is a Protein Coding gene. Diseases associated with WDR63 include Hemometra. An important paralog of this gene is DNAI2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR63 Gene

Genomics for WDR63 Gene

Regulatory Elements for WDR63 Gene

Enhancers for WDR63 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G084971 0.9 ENCODE 12.6 -26.3 -26312 2.4 HDGF FEZF1 THRB RAD21 YY1 RARA GATA2 FOS RELB IKZF2 MCOLN2 WDR63 LPAR3
GH01G084968 0.8 ENCODE 12.1 -29.4 -29443 1.8 USF1 EBF1 RELA ZNF664 ARID3A POLR2A EED ETV6 RELB IKZF2 MCOLN2 MCOLN3 WDR63 LPAR3
GH01G085134 1 Ensembl ENCODE 8.1 +136.1 136120 2.3 FOXA2 ZNF473 CEBPG ZNF23 GATA3 ZNF366 SCRT2 EZH2 GATAD2A RFX1 SYDE2 WDR63 MCOLN2 GC01M085136 MIR4423
GH01G085061 0.9 ENCODE 8 +63.1 63105 1.5 PKNOX1 ATF1 SIN3A ZNF2 GLIS2 FOS SP3 NFYC MBD2 RFX3 MCOLN2 WDR63 MCOLN3 MIR4423
GH01G085047 1 ENCODE 4.4 +49.8 49802 3.1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 KLF7 SP3 REST TSHZ1 ZNF610 MCOLN3 ENSG00000271576 MCOLN2 WDR63 MIR4423
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR63 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR63 Gene

84,999,147 bp from pter
85,133,138 bp from pter
133,992 bases
Plus strand

Genomic View for WDR63 Gene

Genes around WDR63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR63 Gene

Proteins for WDR63 Gene

  • Protein details for WDR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 63
    Protein Accession:
    Secondary Accessions:
    • A8K988
    • Q96L72
    • Q96NU4

    Protein attributes for WDR63 Gene

    891 amino acids
    Molecular mass:
    102935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR63 Gene


neXtProt entry for WDR63 Gene

Post-translational modifications for WDR63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR63 Gene

No data available for DME Specific Peptides for WDR63 Gene

Domains & Families for WDR63 Gene

Gene Families for WDR63 Gene

Protein Domains for WDR63 Gene

Suggested Antigen Peptide Sequences for WDR63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR63: view

No data available for UniProtKB/Swiss-Prot for WDR63 Gene

Function for WDR63 Gene

Phenotypes for WDR63 Gene

genes like me logo Genes that share phenotypes with WDR63: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR63 Gene

Localization for WDR63 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR63 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR63 Gene

Pathways & Interactions for WDR63 Gene

SuperPathways for WDR63 Gene

No Data Available

Interacting Proteins for WDR63 Gene

Selected Interacting proteins: Q8IWG1-WDR63_HUMAN for WDR63 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for WDR63 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR63 Gene

Drugs & Compounds for WDR63 Gene

No Compound Related Data Available

Transcripts for WDR63 Gene

Unigene Clusters for WDR63 Gene

WD repeat domain 63:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR63 Gene

No ASD Table

Relevant External Links for WDR63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR63 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR63 Gene

mRNA differential expression in normal tissues according to GTEx for WDR63 Gene

This gene is overexpressed in Adrenal Gland (x13.0) and Testis (x12.8).

Protein differential expression in normal tissues from HIPED for WDR63 Gene

This gene is overexpressed in Cerebrospinal fluid (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR63 Gene

Protein tissue co-expression partners for WDR63 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR63 Gene:


SOURCE GeneReport for Unigene cluster for WDR63 Gene:

genes like me logo Genes that share expression patterns with WDR63: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR63 Gene

Orthologs for WDR63 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR63 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR63 34 35
  • 99.4 (n)
(Canis familiaris)
Mammalia WDR63 34 35
  • 87.48 (n)
(Bos Taurus)
Mammalia WDR63 35
  • 87 (a)
(Rattus norvegicus)
Mammalia Wdr63 34
  • 80.52 (n)
(Mus musculus)
Mammalia Wdr63 34 16 35
  • 79.82 (n)
(Monodelphis domestica)
Mammalia WDR63 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia WDR63 35
  • 65 (a)
(Gallus gallus)
Aves WDR63 34 35
  • 65.2 (n)
(Anolis carolinensis)
Reptilia WDR63 35
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr63 34
  • 64.67 (n)
(Danio rerio)
Actinopterygii LOC100333131 34
  • 54.62 (n)
WDR63 35
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12489 34
fruit fly
(Drosophila melanogaster)
Insecta CG14838 34 35
  • 43.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009027 34
  • 40.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
Species where no ortholog for WDR63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR63 Gene

Gene Tree for WDR63 (if available)
Gene Tree for WDR63 (if available)

Paralogs for WDR63 Gene

Paralogs for WDR63 Gene

(1) SIMAP similar genes for WDR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR63: view

Variants for WDR63 Gene

Sequence variations from dbSNP and Humsavar for WDR63 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000028420 -- 85,113,522(+) TATAT(G/T)TGAGT intron-variant
rs1000050456 -- 85,109,930(+) GGAAG(A/G/T)AAAAA intron-variant
rs1000064336 -- 85,104,670(+) AATCA(G/T)TGTCT intron-variant
rs1000076313 -- 85,078,262(+) TTGAA(C/T)TCTGT intron-variant
rs1000080404 -- 85,113,109(+) TAATA(C/T)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR63 Gene

Variant ID Type Subtype PubMed ID
esv2763574 CNV loss 21179565
esv34165 CNV loss 18971310
esv3586676 CNV gain 21293372
esv3586677 CNV loss 21293372
nsv462383 CNV gain 19166990
nsv470724 CNV gain 18288195
nsv521770 CNV loss 19592680
nsv523150 CNV loss 19592680
nsv546700 CNV gain 21841781
nsv830459 CNV loss 17160897
nsv947434 CNV duplication 23825009

Variation tolerance for WDR63 Gene

Residual Variation Intolerance Score: 13.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR63 Gene

Disorders for WDR63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR63 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • hematometra
- elite association - COSMIC cancer census association via MalaCards
Search WDR63 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR63

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR63 Gene

Publications for WDR63 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for WDR63 Gene

Sources for WDR63 Gene

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