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Aliases for WDR63 Gene

Aliases for WDR63 Gene

  • WD Repeat Domain 63 2 3
  • Testis Development Protein NYD-SP29 (NYD-SP29) 3
  • Testis Development Protein NYD-SP29 4
  • NYD-SP29 3
  • DIC3 3

External Ids for WDR63 Gene

Previous GeneCards Identifiers for WDR63 Gene

  • GC01P085177
  • GC01P085300
  • GC01P085464
  • GC01P083637

Summaries for WDR63 Gene

GeneCards Summary for WDR63 Gene

WDR63 (WD Repeat Domain 63) is a Protein Coding gene. Diseases associated with WDR63 include hemometra. An important paralog of this gene is DNAI2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR63 Gene

Genomics for WDR63 Gene

Regulatory Elements for WDR63 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR63 Gene

84,999,147 bp from pter
85,133,138 bp from pter
133,992 bases
Plus strand

Genomic View for WDR63 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR63 Gene

Proteins for WDR63 Gene

  • Protein details for WDR63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 63
    Protein Accession:
    Secondary Accessions:
    • A8K988
    • Q96L72
    • Q96NU4

    Protein attributes for WDR63 Gene

    891 amino acids
    Molecular mass:
    102935 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR63 Gene


neXtProt entry for WDR63 Gene

Proteomics data for WDR63 Gene at MOPED

Post-translational modifications for WDR63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR63 Gene

No data available for DME Specific Peptides for WDR63 Gene

Domains & Families for WDR63 Gene

Gene Families for WDR63 Gene

Protein Domains for WDR63 Gene

Suggested Antigen Peptide Sequences for WDR63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 WD repeats.
  • Contains 5 WD repeats.
genes like me logo Genes that share domains with WDR63: view

Function for WDR63 Gene

Gene Ontology (GO) - Molecular Function for WDR63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR63: view

Phenotypes for WDR63 Gene

GenomeRNAi human phenotypes for WDR63:
genes like me logo Genes that share phenotypes with WDR63: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR63

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR63 Gene

Localization for WDR63 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for WDR63 Gene

Pathways & Interactions for WDR63 Gene

SuperPathways for WDR63 Gene

No Data Available

Interacting Proteins for WDR63 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000294664 for WDR63 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR63 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR63 Gene

Drugs & Compounds for WDR63 Gene

No Compound Related Data Available

Transcripts for WDR63 Gene

mRNA/cDNA for WDR63 Gene

Unigene Clusters for WDR63 Gene

WD repeat domain 63:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR63

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR63 Gene

No ASD Table

Relevant External Links for WDR63 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR63 Gene

mRNA expression in normal human tissues for WDR63 Gene

mRNA differential expression in normal tissues according to GTEx for WDR63 Gene

This gene is overexpressed in Adrenal Gland (x13.0) and Testis (x12.8).

Protein differential expression in normal tissues from HIPED for WDR63 Gene

This gene is overexpressed in Cerebrospinal fluid (63.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR63 Gene

SOURCE GeneReport for Unigene cluster for WDR63 Gene Hs.97933

genes like me logo Genes that share expression patterns with WDR63: view

Protein tissue co-expression partners for WDR63 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR63 Gene

Orthologs for WDR63 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR63 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia WDR63 35
  • 87.48 (n)
  • 85.94 (a)
WDR63 36
  • 85 (a)
(Mus musculus)
Mammalia Wdr63 35
  • 79.82 (n)
  • 81.51 (a)
Wdr63 16
Wdr63 36
  • 79 (a)
(Pan troglodytes)
Mammalia WDR63 35
  • 99.4 (n)
  • 99.21 (a)
WDR63 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr63 35
  • 80.52 (n)
  • 81.46 (a)
(Bos Taurus)
Mammalia WDR63 36
  • 87 (a)
(Monodelphis domestica)
Mammalia WDR63 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia WDR63 36
  • 65 (a)
(Gallus gallus)
Aves WDR63 35
  • 65.2 (n)
  • 55.24 (a)
WDR63 36
  • 51 (a)
(Anolis carolinensis)
Reptilia WDR63 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr63 35
  • 64.67 (n)
  • 58.59 (a)
(Danio rerio)
Actinopterygii LOC100333131 35
  • 54.62 (n)
  • 45.5 (a)
WDR63 36
  • 44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12489 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009027 35
  • 40.92 (n)
  • 26.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14838 35
  • 43.56 (n)
  • 27.45 (a)
CG14838 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
Species with no ortholog for WDR63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR63 Gene

Gene Tree for WDR63 (if available)
Gene Tree for WDR63 (if available)

Paralogs for WDR63 Gene

Paralogs for WDR63 Gene

(1) SIMAP similar genes for WDR63 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR63: view

Variants for WDR63 Gene

Sequence variations from dbSNP and Humsavar for WDR63 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs709759 -- 85,108,338(+) GATTG(A/G)GAGGA intron-variant
rs709760 -- 85,109,065(-) TTTCC(A/G)TGGTC intron-variant
rs709761 -- 85,083,791(+) TTCTT(C/T)ACTCC intron-variant
rs709762 -- 85,093,769(-) CCTAG(C/G/T)GAGTA intron-variant
rs709763 -- 85,094,239(+) accag(C/G)cagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR63 Gene

Variant ID Type Subtype PubMed ID
nsv470724 CNV Gain 18288195
nsv462383 CNV Gain 19166990
nsv521770 CNV Loss 19592680
nsv523150 CNV Loss 19592680
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897

Variation tolerance for WDR63 Gene

Residual Variation Intolerance Score: 13.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR63 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR63 Gene

Disorders for WDR63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR63 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • hematometra
- elite association
Search WDR63 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR63

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR63 Gene

Publications for WDR63 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 67
  2. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. (PMID: 24515614) Zhang Y. … Wei S.J. (Protein Cell 2014) 67
  3. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N. … TrAcgouAt D.A. (BMC Med. Genet. 2013) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 67

Products for WDR63 Gene

Sources for WDR63 Gene

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