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WDR62 Gene

protein-coding   GIFtS: 52
GCID: GC19P036545

WD Repeat Domain 62

(Previous names: chromosome 19 open reading frame 14, microcephaly, primary...)
(Previous symbols: C19orf14, MCPH2)
  See WDR62-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 621 2     Chromosome 19 Open Reading Frame 141
C19orf141 2 3 5     WD Repeat-Containing Protein 622
MCPH21 2 5     EC 2.7.11.18
Microcephaly, Primary Autosomal Recessive 21 2     EC 2.7.7.388

External Ids:    HGNC: 245021   Entrez Gene: 2844032   Ensembl: ENSG000000757027   OMIM: 6135835   UniProtKB: O433793   

Export aliases for WDR62 gene to outside databases

Previous GC identifers: GC19P041240 GC19P033051


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR62 Gene:
This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated
with microencephaly, cortical malformations, and mental retardation. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Jan 2011)

GeneCards Summary for WDR62 Gene:
WDR62 (WD repeat domain 62) is a protein-coding gene. Diseases associated with WDR62 include microcephaly, primary autosomal recessive, and microcephaly 2, primary, autosomal recessive, with or without cortical malformations. An important paralog of this gene is MAPKBP1.

UniProtKB/Swiss-Prot: WDR62_HUMAN, O43379
Function: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration

Gene Wiki entry for WDR62 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR62 gene promoter:
         Pax-5   Sp1   LCR-F1   CBF-C   E47   CBF-B   CBF-A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR62 promoter sequence
   Search Chromatin IP Primers for WDR62

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR62


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

WDR62 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR62 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036545:  view genomic region     (about GC identifiers)

Start:
36,545,783 bp from pter      End:
36,596,012 bp from pter
Size:
50,230 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR62_HUMAN, O43379 (See protein sequence)
Recommended Name: WD repeat-containing protein 62  
Size: 1518 amino acids; 165954 Da
Sequence caution: Sequence=AAC27979.1; Type=Erroneous gene model prediction; Sequence=AAH17261.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: Q63HP9 Q659D7 Q8NBF7 Q96AD9
Alternative splicing: 4 isoforms:  O43379-1   O43379-2   O43379-3   O43379-4   (Variant in position: 1078:A->T (in MCPH2, uncertain pathological significance))

Explore the universe of human proteins at neXtProt for WDR62: NX_O43379

Explore proteomics data for WDR62 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for WDR62 (O43379)
     QCLVKSP  LPPSPLE 


    See WDR62 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077430.1  NP_775907.4  

    ENSEMBL proteins: 
     ENSP00000384792   ENSP00000465525   ENSP00000270301   ENSP00000413475   ENSP00000373651  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011047 Quinonprotein_ADH-like_supfam
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O43379

    ProtoNet protein and cluster: O43379

    UniProtKB/Swiss-Prot: WDR62_HUMAN, O43379
    Similarity: Contains 15 WD repeats


    Find genes that share domains with WDR62           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR62_HUMAN, O43379
    Function: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration

         Enzyme Numbers (IUBMB): EC 2.7.7.382 EC 2.7.11.12

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR62           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR62
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    hsa-mir-542-5p (MIRT039350), hsa-mir-1260b (MIRT052764), hsa-mir-877-3p (MIRT037077), hsa-mir-186-5p (MIRT045108), hsa-mir-769-5p (MIRT039175), hsa-mir-149-5p (MIRT045652), hsa-mir-615-3p (MIRT040399), hsa-mir-193b-3p (MIRT016504)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR62_HUMAN, O43379: Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Shows cell cycle-dependent
    localization. Accumulates to the spindle pole during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with WDR62           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR62
    Interactions:

        Search GeneGlobe Interaction Network for WDR62

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for WDR62 (O433792, 3 ENSP000003847924) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK9P459842, 3, ENSP000003214104MINT-68376 I2D: score=5 STRING: ENSP00000321410
    LRIF1Q5T3J32, 3MINT-63143 I2D: score=4 
    TBPP202263, ENSP000002303544I2D: score=4 STRING: ENSP00000230354
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    RALYQ9UKM93I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021987cerebral cortex development IMP--
    GO:0022008neurogenesis IMP--

    Find genes that share ontologies with WDR62           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR62



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR62 gene (2 alternative transcripts): 
    NM_001083961.1  NM_173636.4  

    Unigene Cluster for WDR62:

    WD repeat domain 62
    Hs.116244  [show with all ESTs]
    Unigene Representative Sequence: NM_001083961
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378860(uc002odb.2) ENST00000401500(uc002odd.2 uc002odc.2)
    ENST00000608676 ENST00000587391 ENST00000270301 ENST00000427823 ENST00000589953
    ENST00000388999(uc010eer.3)
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    hsa-miR-223
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    Additional mRNA sequence: 

    AK090617.1 AL117438.1 AL133651.1 BC017261.2 BC058939.1 BC128417.1 

    9 DOTS entries:

    DT.412222  DT.92473513  DT.97783587  DT.97797055  DT.100835202  DT.100754566  DT.121465257  DT.95076463 
    DT.99961200 

    Selected AceView cDNA sequences (see all 102):

    BX283488 BQ956945 BU187036 BE270083 CF272517 BX280857 BI117973 AW574718 
    BU176206 AL041037 CR621762 BU658898 AL041673 AI049908 BG332912 AL560891 
    BQ425501 BU628929 NM_173636 BI085576 BM726953 BX414510 BE560162 BU845609 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR62 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                              -                                                                                             

    ExUns: 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31
    SP1:                                      -                                             
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for WDR62

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR62 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCACTG
    WDR62 Expression
    About this image


    WDR62 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Testis (Reproductive System)
     
     Placenta (Extraembryonic Tissues)
    WDR62 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR62 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116244

    UniProtKB/Swiss-Prot: WDR62_HUMAN, O43379
    Tissue specificity: Present in fetal brain, enriched within the ventricular and subventricular zone (at protein
    level). In the embryonic brain it is expressed in mitotic neural precursor cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR62

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR62 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr621 , 5 WD repeat domain 621, 5 82.32(n)1
    79.95(a)1
      7 (17.34 cM)5
    2330641  NM_146186.31  NP_666298.31 
     302401385 
    lizard
    (Anolis carolinensis)
    Reptilia WDR626
    WD repeat domain 62
    72(a)
    1 ↔ 1
    GL344420.1(699-18010)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr621 WD repeat domain 62 51.58(n)
    46.03(a)
      100493893  XM_002940951.2  XP_002940997.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr621 WD repeat domain 62 55.16(n)
    47.45(a)
      570949  XM_005169694.1  XP_005169751.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73376
    --
    17(a)
    1 → many
    2L(1884622-1944289)
    worm
    (Caenorhabditis elegans)
    Secernentea H24G06.16
    Protein H24G06.1, isoform c (H24G06.1) mRNA, compl...
    13(a)
    1 → many
    V(9446173-9460639) WBGene00019237


    ENSEMBL Gene Tree for WDR62 (if available)
    TreeFam Gene Tree for WDR62 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR62 gene
    MAPKBP12  
    3 SIMAP similar genes for WDR62 using alignment to 2 protein entries:     WDR62_HUMAN (see all proteins):
    DKFZp434J046    MAFK    MAPKBP1

    Find genes that share paralogs with WDR62           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for WDR62
    PGOHUM00000248223


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR62 (see all 1386)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0637034
    Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)4--see VAR_0637032 E K mis40--------
    VAR_0637024
    Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)4--see VAR_0637022 W S mis40--------
    VAR_0658444
    Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)4--see VAR_0658442 R H mis40--------
    VAR_0658434
    Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)4--see VAR_0658432 V M mis40--------
    VAR_0658454
    Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)4--see VAR_0658452 D N mis40--------
    rs1478756591,2
    Cpathogenic136734781(+) TGGACG/AAGCTG 4 /K /E mis11Minor allele frequency- A:0.00NA 4552
    rs596909231,2
    C--33088907(+) TGTGG-/ATGTGG 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs344126141,2
    C--36548423(+) TTTTTT/-GAGAC 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs621097521,2
    C,F--36560620(+) GTAAAC/TGAGAC 2 -- int12Minor allele frequency- T:0.50NA CSA 4
    rs615165201,2
    C--36560657(+) AGGCCA/GAGGCT 2 -- int10--------

    HapMap Linkage Disequilibrium report for WDR62 (36545783 - 36596012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR62:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833815CNV Loss17160897

    Human Gene Mutation Database (HGMD): WDR62
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR62
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR62

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613583   
    OMIM disorders: 604317  
    UniProtKB/Swiss-Prot: WDR62_HUMAN, O43379
  • Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2)
    [MIM:604317]: A disease characterized by microcephaly, moderate to severe mental retardation, and various type of
    cortical malformations in most patients. Microcephaly is defined as a head circumference more than 3 standard
    deviations below the age-related mean. Cortical malformations include pachygyria with cortical thickening,
    microgyria, lissencephaly, hypoplasia of the corpus callosum, schizencephaly. All affected individuals have
    delayed psychomotor development. Some patients have seizures. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 8 diseases for WDR62:    
    About MalaCards
    microcephaly, primary autosomal recessive    microcephaly 2, primary, autosomal recessive, with or without cortical malformations    primary autosomal recessive microcephaly type 2    microcephaly, cortical malformations, and mental retardation
    primary autosomal recessive microcephalies and seckel syndrome spectrum disorders    primary autosomal recessive microcephaly type 1    microcephaly    priapism

    1 disease from the University of Copenhagen DISEASES database for WDR62:
    Microcephaly

    Find genes that share disorders with WDR62           About GenesLikeMe


    Export disorders for WDR62 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR62 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with WDR62)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations. (PubMed id 21496009)1, 2, 3 Bhat V.... Kumar A. (Clin. Genet. 2011)
    2. Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. (PubMed id 20729831)1, 2, 3 Bilguvar K.... Gunel M. (Nature 2010)
    3. Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. (PubMed id 20890278)1, 2, 3 Yu T.W.... Walsh C.A. (Nat. Genet. 2010)
    4. A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation. (PubMed id 19910486)1, 3 Wasserman T....Aronheim A. (Mol. Biol. Cell 2010)
    5. WDR62 is associated with the spindle pole and is mutated in human microcephaly. (PubMed id 20890279)1, 2 Nicholas A.K.... Woods C.G. (Nat. Genet. 2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 284403 HGNC: 24502 AceView: C19orf14 Ensembl:ENSG00000075702 euGenes: HUgn284403
    ECgene: WDR62 H-InvDB: WDR62

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR62 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR62 gene:
    Search GeneIP for patents involving WDR62

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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