Aliases for WDR62 Gene
Aliases for WDR62 Gene
External Ids for WDR62 Gene
- HGNC: 24502
- Entrez Gene: 284403
- Ensembl: ENSG00000075702
- OMIM: 613583
- UniProtKB: O43379
Previous HGNC Symbols for WDR62 Gene
- C19orf14
- MCPH2
Previous GeneCards Identifiers for WDR62 Gene
- GC19P041240
- GC19P036545
- GC19P033051
Summaries for WDR62 Gene
-
This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
GeneCards Summary for WDR62 Gene
WDR62 (WD Repeat Domain 62) is a Protein Coding gene. Diseases associated with WDR62 include Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations and Second-Degree Atrioventricular Block. An important paralog of this gene is MAPKBP1.
UniProtKB/Swiss-Prot for WDR62 Gene
-
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Additional gene information for WDR62 Gene
- Monarch Initiative
- Search for WDR62 at DataMed
- Search for WDR62 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR62 Gene
Genomics for WDR62 Gene
GeneHancer (GH) Regulatory Elements for WDR62 Gene
Promoters and enhancers for WDR62 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around WDR62 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for WDR62 Gene
Genomic Locations for WDR62 Gene
- chr19:36,054,881-36,105,111
- (GRCh38/hg38)
- Size:
- 50,231 bases
- Orientation:
- Plus strand
- chr19:36,545,783-36,596,012
- (GRCh37/hg19)
Genomic View for WDR62 Gene
Genes around WDR62 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.12 by Ensembl
- 19q13.12 by Entrez Gene
- 19q13.12 by HGNC
WDR62 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for WDR62 Gene
Proteins for WDR62 Gene
-
Protein details for WDR62 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43379-WDR62_HUMAN
- Recommended name:
- WD repeat-containing protein 62
- Protein Accession:
- O43379
- Q63HP9
- Q659D7
- Q8NBF7
- Q96AD9
Protein attributes for WDR62 Gene
- Size:
- 1518 amino acids
- Molecular mass:
- 165954 Da
- Quaternary structure:
-
- Can form homodimers (via C-terminus) (PubMed:23341463). Interacts (via C-terminus) with MAPKBP1 (via C-terminus) (PubMed:23341463, PubMed:28089251). Interacts with CDK5RAP2, CEP152, CEP63 and KIAA0753 (PubMed:26297806). CEP63, CDK5RAP2, CEP152, WDR62 are proposed to form a stepwise assembled complex at the centrosome forming a ring near parental centrioles (PubMed:26297806).
- SequenceCaution:
-
- Sequence=AAC27979.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH17261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for WDR62 Gene
Selected DME Specific Peptides for WDR62 Gene
- O43379:
-
- QCLVKSP
- LPPSPLE
Post-translational modifications for WDR62 Gene
No Post-translational modifications
Other Protein References for WDR62 Gene
Antibody Products
- Novus Biologicals Antibodies for WDR62
-
Abcam antibodies for WDR62
- Invitrogen Antibodies for WDR62
- GeneTex WDR62 antibody for WDR62
-
Santa Cruz Biotechnology (SCBT) Antibodies for WDR62
Protein Products
-
OriGene Purified Proteins for WDR62
- Search Origene for MassSpec and Protein Over-expression Lysates for WDR62
- Origene Custom Protein Services for WDR62
- Novus Biologicals proteins for WDR62
- Search GeneTex for Proteins for WDR62
-
Abcam proteins for WDR62
Assay Products
Domains & Families for WDR62 Gene
Gene Families for WDR62 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Protein Domains for WDR62 Gene
Suggested Antigen Peptide Sequences for WDR62 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for WDR62 Gene
Function for WDR62 Gene
Molecular function for WDR62 Gene
- UniProtKB/Swiss-Prot Function:
- Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).
Enzyme Numbers (IUBMB) for WDR62 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
Phenotypes for WDR62 Gene
- MGI mutant phenotypes for WDR62:
- inferred from 2 alleles
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for WDR62
-
-
ViGene Biosciences lentiviral particle packaged cDNA for WDR62 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WDR62 gene
- Search ViGene Biosciences for WDR62
CRISPR Products
-
OriGene CRISPR knockouts for WDR62
- genomics-online: gRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- Applied Biological Materials CRISPR for WDR62
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WDR62
- GenScript: Design CRISPR guide RNA sequences for WDR62
miRNA for WDR62 Gene
- miRTarBase miRNAs that target WDR62
miRNA Products
- Search ViGene Biosciences for WDR62
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for WDR62
- Browse OriGene Inhibitory RNA Products For WDR62
- genomics-online: shRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for WDR62 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for WDR62
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WDR62
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WDR62
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for WDR62
-
ViGene Biosciences adenoviral particle packaged cDNA for WDR62 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for WDR62 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for WDR62 gene
No data available for Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR62 Gene
Localization for WDR62 Gene
Subcellular locations from UniProtKB/Swiss-Prot for WDR62 Gene
- Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000269 PubMed:20890278, ECO:0000269 PubMed:26297806}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 3 |
- Cytosol (4)
- Microtubule organizing center (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000922 | spindle pole | IDA | 20890278 |
| GO:0005634 | nucleus | IDA,IEA | 20729831 |
| GO:0005682 | U5 snRNP | IBA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IDA | 26297806 |
Pathways & Interactions for WDR62 Gene
No Data Available
Interacting Proteins for WDR62 Gene
Selected Interacting proteins:
O43379-WDR62_HUMAN
ENSP00000384792
for WDR62 Gene via
IID
UniProtKB
STRING
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007052 | mitotic spindle organization | IMP | 24388750 |
| GO:0007099 | centriole replication | IMP | 26297806 |
| GO:0007399 | nervous system development | IEA | -- |
| GO:0008380 | RNA splicing | IBA | -- |
| GO:0021987 | cerebral cortex development | IMP | 20729831 |
No data available for Pathways by source and SIGNOR curated interactions for WDR62 Gene
Transcripts for WDR62 Gene
mRNA/cDNA for WDR62 Gene
- (12) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (102) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for WDR62 Gene
- WD repeat domain 62:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for WDR62
- genomics-online: gRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- Applied Biological Materials CRISPR for WDR62
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for WDR62
- GenScript: Design CRISPR guide RNA sequences for WDR62
miRNA Products
- Search ViGene Biosciences for WDR62
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for WDR62
- Browse OriGene Inhibitory RNA Products For WDR62
- genomics-online: shRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for WDR62 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for WDR62
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WDR62
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for WDR62
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - |
| ExUns: | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||
| SP8: |
Expression for WDR62 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for WDR62 Gene
This gene is overexpressed in Testis (x24.5), Heart - Left Ventricle (x4.5), and Muscle - Skeletal (x4.0).
This gene is overexpressed in Testis (34.0), Ovary (21.4), and Plasma (13.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR62 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of WDR62 Gene:
WDR62SOURCE GeneReport for Unigene cluster for WDR62 Gene:
Hs.116244mRNA Expression by UniProt/SwissProt for WDR62 Gene:
O43379-WDR62_HUMAN
Tissue specificity:
Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level). In the embryonic brain it is expressed in mitotic neural precursor cells.
Evidence on tissue expression from TISSUES for WDR62 Gene
- Muscle(4.1)
- Nervous system(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR62 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- cerebellum
- chin
- cranial nerve
- eye
- eyelid
- face
- forehead
- head
- jaw
- lip
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
Pelvis:
- pelvis
- ureter
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for WDR62
- genomics-online: primer clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
Orthologs for WDR62 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | WDR62 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | WDR62 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | WDR62 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Wdr62 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Wdr62 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | WDR62 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | WDR62 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | WDR62 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | wdr62 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | wdr62 33 |
|
||
| WDR62 34 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7337 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | H24G06.1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for WDR62 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for WDR62 Gene
(3) SIMAP similar genes for WDR62 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for WDR62 Gene
Variants for WDR62 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1008328 | benign, not specified, Primary Microcephaly 2 With or Without Cortical Malformations, Primary autosomal recessive microcephaly 2 | 36,104,534(+) | A/C | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs1054040 | uncertain-significance, Primary autosomal recessive microcephaly 2 | 36,103,401(+) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, synonymous_variant | |
| rs111294536 | likely-benign, uncertain-significance, not specified, Primary Microcephaly 2 With or Without Cortical Malformations | 36,103,640(+) | C/A/G/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs112789274 | uncertain-significance, Primary Microcephaly 2 With or Without Cortical Malformations | 36,084,753(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs11538454 | benign, likely-benign, not specified, Primary Microcephaly 2 With or Without Cortical Malformations, Primary autosomal recessive microcephaly 2 | 36,058,788(+) | C/A/G/T | coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant |
Residual Variation Intolerance Score:
45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.65;
65.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for WDR62 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR62 Gene
Disorders for WDR62 Gene
(9) MalaCards diseases for WDR62 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microcephaly 2, primary, autosomal recessive, with or without cortical malformations |
|
|
| second-degree atrioventricular block |
|
|
| microcephaly |
|
|
| pachygyria |
|
|
| schizencephaly |
|
|
Search WDR62 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
WDR62_HUMAN- Microcephaly 2, primary, autosomal recessive, with or without cortical malformations (MCPH2) [MIM:604317]: A disease characterized by microcephaly, moderate to severe mental retardation, and various type of cortical malformations in most patients. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Cortical malformations include pachygyria with cortical thickening, microgyria, lissencephaly, hypoplasia of the corpus callosum, schizencephaly. All affected individuals have delayed psychomotor development. Some patients have seizures. {ECO:0000269 PubMed:20729831, ECO:0000269 PubMed:20890278, ECO:0000269 PubMed:20890279, ECO:0000269 PubMed:21496009}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for WDR62
No data available for Genatlas for WDR62 Gene
Publications for WDR62 Gene
- Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations. (PMID: 21496009) Bhat V … Kumar A (Clinical genetics 2011) 2 3 4 58
- Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations. (PMID: 20729831) Bilgüvar K … Günel M (Nature 2010) 2 3 4 58
- Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture. (PMID: 20890278) Yu TW … Walsh CA (Nature genetics 2010) 2 3 4 58
- Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. (PMID: 28089251) Macia MS … Benmerah A (American journal of human genetics 2017) 3 4 58
- Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. (PMID: 26297806) Kodani A … Reiter JF (eLife 2015) 3 4 58
Products for WDR62 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for WDR62
- Search Origene for MassSpec and Protein Over-expression Lysates for WDR62
- Origene Custom Protein Services for WDR62
- Origene shrna, sirna, and RNAi products in human, mouse, rat for WDR62
- Browse OriGene Inhibitory RNA Products For WDR62
- OriGene qPCR primer pairs for WDR62
- OriGene CRISPR knockouts for WDR62
- OriGene ORF clones in human for WDR62
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For WDR62
- GenScript: Next-day shipping of latest version cDNA ORF clones for WDR62 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for WDR62
- GenScript Custom Assay Services for WDR62
- GenScript Custom overexpressing Cell Line Services for WDR62
- GenScript: Design CRISPR guide RNA sequences for WDR62
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for WDR62
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for WDR62
- Novus Biologicals proteins for WDR62
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for WDR62
- Abcam proteins for WDR62
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for WDR62
- Cyagen custom Knockout/knockin (KOKI) mouse models for WDR62
- VectorBuilder custom plasmid, inducible vectors for WDR62
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for WDR62
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 8 available WDR62 Antibodies ranked by validation data
- Compare Top WDR62 Antibodies
- Quality Products:
- antibodies-online: Search results for available WDR62 related products ranked by validation data
- antibodies-online: Search results for available WDR62 related products ranked by validation data
- GeneTex WDR62 antibody for WDR62
- Search GeneTex for Proteins for WDR62
- ViGene Biosciences adenoviral particle packaged cDNA for WDR62 gene
- ViGene Biosciences lentiviral particle packaged cDNA for WDR62 gene
- ViGene Biosciences ready-to-package AAV shRNAs for WDR62 gene
- Search ViGene Biosciences for WDR62
- Santa Cruz Biotechnology (SCBT) Antibodies for WDR62
- Search Santa Cruz Biotechnology (SCBT) for WDR62 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for WDR62
- Horizon Cell Lines for WDR62
- genomics-online: cdna clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- orf clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- genomics-online: gRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- genomics-online: primer clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
- genomics-online: shRNA clones - Search results for 80 available WDR62 gene related products
- Overview of 80 available WDR62 gene related products
Sources for WDR62 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew