Aliases for WDR62 Gene
External Ids for WDR62 Gene
Previous HGNC Symbols for WDR62 Gene
Previous GeneCards Identifiers for WDR62 Gene
This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
GeneCards Summary for WDR62 Gene
WDR62 (WD Repeat Domain 62) is a Protein Coding gene. Diseases associated with WDR62 include Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations and Primary Autosomal Recessive Microcephaly Type 2. An important paralog of this gene is MAPKBP1.
UniProtKB/Swiss-Prot for WDR62 Gene
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).