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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR61 Gene

protein-coding   GIFtS: 55
GCID: GC15M078575

WD Repeat Domain 61

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 611 2     SKI82
Meiotic Recombination REC14 Protein Homolog2 3     Recombination Protein REC142
SKI8 Homolog2 3     WD Repeat-Containing Protein 612
REC142     Ski83

External Ids:    HGNC: 303001   Entrez Gene: 803492   Ensembl: ENSG000001403957   OMIM: 6095405   UniProtKB: Q9GZS33   

Export aliases for WDR61 gene to outside databases

Previous GC identifers: GC15M076363 GC15M055333


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR61 Gene:
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are
involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 (PubMed
16024656)).(supplied by OMIM, Mar 2008)

GeneCards Summary for WDR61 Gene: 
WDR61 (WD repeat domain 61) is a protein-coding gene. Diseases associated with WDR61 include keratoconus, and influenza, and among its related super-pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include protein binding. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA
polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.
PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and
'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and
synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for
transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional
activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins,
such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3
ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination
of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to
transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A)
factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3),
dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex
which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes
in a manner dependent on PAF1C




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR61 gene promoter:
         GR   p53   GR-beta   MIF-1   Nkx2-5   ARP-1   FOXO1a   GR-alpha   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR61 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR61

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

WDR61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR61 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078575:  view genomic region     (about GC identifiers)

Start:
78,570,177 bp from pter      End:
78,592,136 bp from pter
Size:
21,960 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3 (See protein sequence)
Recommended Name: WD repeat-containing protein 61  
Size: 305 amino acids; 33581 Da
Subunit: Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of
the SKI complex which consists of WDR61, SKIV2L and TTC37
Subcellular location: Nucleus. Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for WDR61:
3OW8 (3D)    
Secondary accessions: D3DW84 Q6IA22 Q7Z4X4

Explore the universe of human proteins at neXtProt for WDR61: NX_Q9GZS3

Explore proteomics data for WDR61 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZS3

  • WDR61 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR61 Protein Expression
    REFSEQ proteins: NP_079510.1  
    ENSEMBL proteins: 
     ENSP00000453118   ENSP00000455689   ENSP00000453801   ENSP00000267973   ENSP00000453024  
     ENSP00000453902   ENSP00000453493   ENSP00000453589  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDR61 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016593Cdc73/Paf1 complex IDA--
    GO:0035327transcriptionally active chromatin IDA16024656

    WDR61 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZS3

    ProtoNet protein and cluster: Q9GZS3

    UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
    Similarity: Contains 7 WD repeats


    WDR61 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR61_HUMAN, Q9GZS3
    Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA
    polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.
    PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and
    'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and
    synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for
    transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional
    activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins,
    such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
    ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3
    ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination
    of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to
    transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A)
    factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
    regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3),
    dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex
    which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes
    in a manner dependent on PAF1C

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16024656
         
    WDR61 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR61:
     Decreased Wnt reporter activit 

    Animal Models:
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for WDR61 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for WDR61):
        RNA degradation


    WDR61 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR61

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for WDR61 (Q9GZS31, 2, 3 ENSP000002679734) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTR9Q6PD621, 3, ENSP000003550134EBI-358545,EBI-1019583 I2D: score=3 STRING: ENSP00000355013
    EZH2Q159102, 3MINT-64279 I2D: score=5 
    RIPK3Q9Y5722, 3MINT-49108 I2D: score=2 
    YWHAZP631042, 3MINT-3295348 I2D: score=1 
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter IDA--
    GO:0045638negative regulation of myeloid cell differentiation IDA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--

    WDR61 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR61

    Search CenterWatch for drugs/clinical trials and news about WDR61

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR61 gene: 
    NM_025234.1  

    Unigene Cluster for WDR61:

    WD repeat domain 61
    Hs.513055  [show with all ESTs]
    Unigene Representative Sequence: AK025098
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558453 ENST00000560807 ENST00000558412 ENST00000559332 ENST00000559940
    ENST00000558311(uc002bdo.3) ENST00000267973(uc002bdn.3) ENST00000558459
    ENST00000560569 ENST00000560610 ENST00000559848 ENST00000560063(uc010umz.1)
    ENST00000559700(uc010una.1) ENST00000558840 ENST00000560946 ENST00000561347(uc010blc.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR61:
    hsa-miR-1283
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF100786.1 AF127799.1 AF309553.1 AK024754.1 AK025098.2 AK300838.1 AK304617.1 AK310477.1 
    AK311320.1 AL109709.2 BC010080.2 CR457333.1 

    15 DOTS entries:

    DT.111702  DT.100816886  DT.95173113  DT.86996941  DT.91770399  DT.100816891  DT.305586  DT.97774577 
    DT.100816890  DT.40126061  DT.97769084  DT.95173112  DT.40206999  DT.91661179  DT.91770401 

    24/227 AceView cDNA sequences (see all 227):

    BE281400 AL525591 BQ671031 AA033675 BU194114 BU789122 BM452906 BU948164 
    BU174325 AW006396 BE302111 AF100786 BG030703 AA312242 BM843253 AI339027 
    AL520032 BF590110 CB109379 CR591993 CR619418 BQ441897 AI934724 CD515172 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -     -           -           -           -                 -                                   -                           
    SP2:                                                        -           -                 -                                   -                           
    SP3:                                                        -     -     -     -     -     -                                   -                           
    SP4:                          -     -           -           -                             -                                                               
    SP5:                          -     -           -           -           -                                                                                 


    ECgene alternative splicing isoforms for WDR61

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR61 expression in normal human tissues (normalized intensities)      WDR61 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTGGA
    WDR61 Expression
    About this image


    WDR61 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See WDR61 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR61

    SOURCE GeneReport for Unigene cluster: Hs.513055
        SABiosciences Custom PCR Arrays for WDR61
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR61 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr611 , 5 WD repeat domain 611, 5 92.79(n)1
    97.38(a)1
      9 (29.73 cM)5
    663171  NM_001025375.11  NP_001020546.11 
     547147355 
    chicken
    (Gallus gallus)
    Aves WDR611 WD repeat domain 61 82.4(n)
    93.44(a)
      415359  NM_001005805.1  NP_001005805.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR616
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343486.1(74738-81366)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239222 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BJ069622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc776752 hypothetical protein MGC77675 78.01(n)   393827  BC062834.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39091 CG3909 58.56(n)
    56.67(a)
      41226  NM_141712.3  NP_649969.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F02E9.106
    Protein F02E9.10, isoform b
    11(a)
    possible ortholog
    I(8426987-8429832)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKI8(YGL213C)4 Ski complex component and WD-repeat protein, mediates more   --   7(91247-90054) 852659  NP_011302.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VIP31 WD repeat-containing protein 61 51.33(n)
    40.48(a)
      829105  NM_119129.2  NP_194712.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06603001 hypothetical protein 49.71(n)
    41.87(a)
      4351059  NM_001074935.1  NP_001068403.1 


    ENSEMBL Gene Tree for WDR61 (if available)
    TreeFam Gene Tree for WDR61 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR61 gene
    TAF52  WSB22  WSB12  TAF5L2  
    18/19 SIMAP similar genes for WDR61 using alignment to 7 protein entries:     WDR61_HUMAN (see all proteins) (see all similar genes):
    STRAP    WSB1    PAAF1    WSB2    GNB5    GNB2
    PF20    SMU1    KATNB1    GNB3    GNB4    TBL3
    WDR48    DAW1    GNB2L1    COPB2    POC1B    PLRG1

    WDR61 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 SNPs in WDR61 are shown (see all 398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71704921,2
    C,H--78575142(+) GGCTTG/CAGCCT 1 -- int116Minor allele frequency- C:0.00NS EA NA WA CSA 549
    rs1915119881,2
    --78575186(+) CCTTCC/TGATAC 1 -- int10--------
    rs1460890211,2
    C--78575273(+) AGTGG-/AAAGGA 1 -- int10--------
    rs1833855951,2
    --78575280(+) AGGATA/GCCCAG 1 -- int10--------
    rs1480703211,2
    --78575313(+) CCTATA/GCAGTC 1 -- int10--------
    rs1157041841,2
    F--78575316(+) ATGCAG/ATCAAA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1863390671,2
    --78575338(+) CTTCAA/GGACTC 1 -- int10--------
    rs595647711,2
    C,F--78575379(+) AGCTCC/TGGGGA 1 -- int14Minor allele frequency- T:0.17WA CSA 123
    rs1146544241,2
    F--78575393(+) CGCTGC/TTGTAT 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1900109021,2
    --78575585(+) GCATTA/CAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR61 (78570177 - 78592136 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WDR61: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR61
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR61

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609540    OMIM disorders: --

    2 diseases for WDR61:    About MalaCards
    keratoconus    influenza


    WDR61 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR61

    Export disorders for WDR61 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR61 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with WDR61)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human PAF1 complex acts in chromatin transcriptio n elongation both independently and cooperatively with SII/TFIIS. (PubMed id 20178742)1, 2 Kim J....Roeder R.G. (2010)
    2. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PubMed id 16024656)1, 2 Zhu B....Reinberg D. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. OTUB1 modulates c-IAP1 stability to regulate signallin g pathways. (PubMed id 23524849)1 Goncharov T....Vucic D. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. Histone H3R17me2a mark recruits human RNA polymerase-a ssociated factor 1 complex to activate transcription. (PubMed id 22451921)1 Wu J. and Xu W. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80349 HGNC: 30300 AceView: REC14 Ensembl:ENSG00000140395 euGenes: HUgn80349
    ECgene: WDR61 Kegg: 80349 H-InvDB: WDR61

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR61 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR61 gene:
    Search GeneIP for patents involving WDR61

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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