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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR61 Gene

protein-coding   GIFtS: 51
GCID: GC15M078575

WD repeat domain 61

 Explore 3 diseases affiliated with
WDR61 via our new
 Human Malady Compendium 
Biological research products
for WDR61
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
WD Repeat Domain 611 2     SKI82
REC141 2     Recombination Protein REC142
Meiotic Recombination REC14 Protein Homolog2 3     WD Repeat-Containing Protein 612
SKI8 Homolog2 3     Ski83

External Ids:    HGNC: 303001   Entrez Gene: 803492   Ensembl: ENSG000001403957   OMIM: 6095405   UniProtKB: Q9GZS33   

Export aliases for WDR61 gene to outside databases

Previous GC identifers: GC15M076363 GC15M055333


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR61:
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in
events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 (PubMed 16024656)).(supplied by OMIM,
Mar 2008)

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II
and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates
with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated
forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in
cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C
is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though
association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone
modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits
the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be
coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and
poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on
histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to
be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on
PAF1C




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR61 gene promoter:
         GR   p53   GR-beta   MIF-1   Nkx2-5   ARP-1   FOXO1a   GR-alpha   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR61 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR61

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

WDR61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR61 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078575:  view genomic region     (about GC identifiers)

Start:
78,570,177 bp from pter      End:
78,592,136 bp from pter
Size:
21,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3 (See protein sequence)
Recommended Name: WD repeat-containing protein 61  
Size: 305 amino acids; 33581 Da
Subunit: Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI
complex which consists of WDR61, SKIV2L and TTC37
Subcellular location: Nucleus. Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for WDR61:
3OW8 (3D)    
Secondary accessions: D3DW84 Q6IA22 Q7Z4X4

Explore the universe of human proteins at neXtProt for WDR61: NX_Q9GZS3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9GZS3

  • WDR61 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_079510.1  
    ENSEMBL proteins: 
     ENSP00000453118   ENSP00000455689   ENSP00000453801   ENSP00000267973   ENSP00000453024  
     ENSP00000453902   ENSP00000453493   ENSP00000453589  

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    Novus Biologicals WDR61 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for WDR61

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016593Cdc73/Paf1 complex IDA--
    GO:0035327transcriptionally active chromatin IDA16024656


    WDR61 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for WDR61


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    WDR61 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZS3

    ProtoNet protein and cluster: Q9GZS3

    UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
    Similarity: Contains 7 WD repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
    Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II
    and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates
    with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated
    forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in
    cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C
    is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though
    association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone
    modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits
    the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate
    monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be
    coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and
    poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
    regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on
    histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to
    be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on
    PAF1C

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    WDR61 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for WDR61:
     Decreased Wnt reporter activit 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Deadenylation-dependent mRNA decay
    RNA degradation0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for WDR61):
        RNA degradation


    WDR61 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR61

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for WDR61 (Q9GZS31, 2, 3 ENSP000002679734) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTR9Q6PD621, 3, ENSP000003550134EBI-358545,EBI-1019583 I2D: score=3 STRING: ENSP00000355013
    EZH2Q159102, 3MINT-64279 I2D: score=5 
    RIPK3Q9Y5722, 3MINT-49108 I2D: score=2 
    YWHAZP631042, 3MINT-3295348 I2D: score=1 
    RTF1Q925413, ENSP000003742804I2D: score=2 STRING: ENSP00000374280
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter IDA--
    GO:0045638negative regulation of myeloid cell differentiation IDA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--


    WDR61 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR61
    Search CenterWatch for drugs/clinical trials and news about WDR61 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR61 gene: 
    NM_025234.1  

    Unigene Cluster for WDR61:

    WD repeat domain 61
    Hs.513055  [show with all ESTs]
    Unigene Representative Sequence: AK025098
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558453 ENST00000560807 ENST00000558192 ENST00000558412 ENST00000559332
    ENST00000559940 ENST00000558311(uc002bdo.3) ENST00000267973(uc002bdn.3)
    ENST00000558459 ENST00000560569 ENST00000560610 ENST00000559848 ENST00000560063(uc010umz.1)
    ENST00000559700(uc010una.1) ENST00000558840 ENST00000560946 ENST00000561347(uc010blc.1)


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    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR61:
    hsa-miR-1283
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    Inhib. RNA
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    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR61
    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR61 (see all 4)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR61

    Additional cDNA sequence: 

    AF100786.1 AF127799.1 AF309553.1 AK024754.1 AK025098.2 AK300838.1 AK304617.1 AK310477.1 
    AK311320.1 AL109709.2 BC010080.2 CR457333.1 

    15 DOTS entries:

    DT.111702  DT.100816886  DT.95173113  DT.86996941  DT.91770399  DT.100816891  DT.305586  DT.97774577 
    DT.100816890  DT.40126061  DT.97769084  DT.95173112  DT.40206999  DT.91661179  DT.91770401 

    24/227 AceView cDNA sequences (see all 227):

    BE281400 CB109379 CR613745 CR601896 BM472013 CR592884 AI339027 CR619418 
    BU194114 BQ213470 BG030703 BF590110 BI838897 AA033675 BQ671031 AI890022 
    BM452906 BU948164 AA312242 AF100786 CD514959 BX090814 BE645689 BM843253 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -     -           -           -           -                 -                                   -                           
    SP2:                                                        -           -                 -                                   -                           
    SP3:                                                        -     -     -     -     -     -                                   -                           
    SP4:                          -     -           -           -                             -                                                               
    SP5:                          -     -           -           -           -                                                                                 


    ECgene alternative splicing isoforms for WDR61

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR61 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTATTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See WDR61 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR61

    SOURCE GeneReport for Unigene cluster: Hs.513055
        SABiosciences Custom PCR Arrays for WDR61
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR61
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR61 gene from 8/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr611 , 5 WD repeat domain 611, 5 92.79(n)1
    97.38(a)1
      9 (29.73 cM)5
    663171  NM_001025375.11  NP_001020546.11 
     547147355 
    chicken
    (Gallus gallus)
    Aves WDR611 WD repeat domain 61 82.4(n)
    93.44(a)
      415359  NM_001005805.1  NP_001005805.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR616
    TBL36
    --
    88(a)
    6(a)
    1 ↔ 1
    possible ortholog
    GL343486.1(75119-81345)
    GL344276.1(73199-85629)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239222 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BJ069622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc776752 hypothetical protein MGC77675 78.01(n)   393827  BC062834.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39091 CG3909 58.56(n)
    56.67(a)
      41226  NM_141712.3  NP_649969.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VIP31 WD repeat-containing protein 61 51.33(n)
    40.48(a)
      829105  NM_119129.2  NP_194712.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06603001 hypothetical protein 49.71(n)
    41.87(a)
      4351059  NM_001074935.1  NP_001068403.1 


    ENSEMBL Gene Tree for WDR61 (if available)
    TreeFam Gene Tree for WDR61 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR61 gene
    SMU12  APAF12  
    18/20 SIMAP similar genes for WDR61 using alignment to 7 protein entries:     WDR61_HUMAN (see all proteins) (see all similar genes):
    STRAP    WSB1    PAAF1    WSB2    GNB5    GNB2
    PF20    SMU1    KATNB1    GNB1    TBL3    GNB3
    GNB4    WDR48    WDR69    GNB2L1    COPB2    POC1B

    WDR61 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/336 NCBI SNPs in WDR61 are shown (see all 336    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71704921,2
    C,H,--78575142(+) GGCTTG/CAGCCT 1 -- int116Minor allele frequency- C:0.00NS EA NA WA CSA 549
    rs1915119881,2
    --78575186(+) CCTTCC/TGATAC 1 -- int10--------
    rs1460890211,2
    --78575273(+) AGTGG-/AAAGGA 1 -- int10--------
    rs1833855951,2
    --78575280(+) AGGATA/GCCCAG 1 -- int10--------
    rs1480703211,2
    --78575313(+) CCTATA/GCAGTC 1 -- int10--------
    rs1157041841,2
    F,--78575316(+) ATGCAG/ATCAAA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1863390671,2
    --78575338(+) CTTCAA/GGACTC 1 -- int10--------
    rs595647711,2
    C,F,--78575379(+) AGCTCC/TGGGGA 1 -- int14Minor allele frequency- T:0.17WA CSA 123
    rs1146544241,2
    F,--78575393(+) CGCTGC/TTGTAT 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1900109021,2
    --78575585(+) GCATTA/CAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR61 (78570177 - 78592136 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for WDR61: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR61
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR61

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDR61 for disorders           About GeneDecksing

    OMIM gene information: 609540    OMIM disorders: --

    3 diseases for WDR61:    About MalaCards
    keratoconus    hematopoiesis    influenza


    Export disorders for WDR61 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR61 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with WDR61)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human PAF1 complex acts in chromatin transcriptio n elongation both independently and cooperatively with SII/TFIIS. (PubMed id 20178742)1, 2 Kim J....Roeder R.G. (2010)
    2. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PubMed id 16024656)1, 2 Zhu B....Reinberg D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Histone H3R17me2a mark recruits human RNA polymerase-a ssociated factor 1 complex to activate transcription. (PubMed id 22451921)1 Wu J. and Xu W. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80349 HGNC: 30300 AceView: REC14 Ensembl:ENSG00000140395 euGenes: HUgn80349
    ECgene: WDR61 Kegg: 80349 H-InvDB: WDR61

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR61 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR61 gene:
    Search GeneIP for patents involving WDR61

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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