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Aliases for WDR61 Gene

Aliases for WDR61 Gene

  • WD Repeat Domain 61 2 3 5
  • Meiotic Recombination REC14 Protein Homolog 3 4
  • SKI8 Homolog 3 4
  • SKI8 3 4
  • Recombination Protein REC14 3
  • REC14 3

External Ids for WDR61 Gene

Previous GeneCards Identifiers for WDR61 Gene

  • GC15M076363
  • GC15M078575
  • GC15M055333

Summaries for WDR61 Gene

Entrez Gene Summary for WDR61 Gene

  • WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WDR61 Gene

WDR61 (WD Repeat Domain 61) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay. An important paralog of this gene is WDR5B.

UniProtKB/Swiss-Prot for WDR61 Gene

  • Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3), dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR61 Gene

Genomics for WDR61 Gene

Regulatory Elements for WDR61 Gene

Promoters for WDR61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR61 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR61 Gene

Chromosome:
15
Start:
78,277,835 bp from pter
End:
78,299,794 bp from pter
Size:
21,960 bases
Orientation:
Minus strand

Genomic View for WDR61 Gene

Genes around WDR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR61 Gene

Proteins for WDR61 Gene

  • Protein details for WDR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS3-WDR61_HUMAN
    Recommended name:
    WD repeat-containing protein 61
    Protein Accession:
    Q9GZS3
    Secondary Accessions:
    • D3DW84
    • Q6IA22
    • Q7Z4X4

    Protein attributes for WDR61 Gene

    Size:
    305 amino acids
    Molecular mass:
    33581 Da
    Quaternary structure:
    • Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI complex which consists of WDR61, SKIV2L and TTC37.

    Three dimensional structures from OCA and Proteopedia for WDR61 Gene

neXtProt entry for WDR61 Gene

Proteomics data for WDR61 Gene at MOPED

Post-translational modifications for WDR61 Gene

  • Ubiquitination at Lys 45 and Lys 97
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for WDR61 Gene

Domains & Families for WDR61 Gene

Suggested Antigen Peptide Sequences for WDR61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZS3

UniProtKB/Swiss-Prot:

WDR61_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR61: view

Function for WDR61 Gene

Molecular function for WDR61 Gene

UniProtKB/Swiss-Prot Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3), dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.
genes like me logo Genes that share phenotypes with WDR61: view

Animal Model Products

miRNA for WDR61 Gene

miRTarBase miRNAs that target WDR61

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR61 Gene

Localization for WDR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR61 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR61 Gene COMPARTMENTS Subcellular localization image for WDR61 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16024656
GO:0055087 Ski complex IDA 16024656
genes like me logo Genes that share ontologies with WDR61: view

Pathways & Interactions for WDR61 Gene

SuperPathways for WDR61 Gene

Superpath Contained pathways
1 Deadenylation-dependent mRNA decay
genes like me logo Genes that share pathways with WDR61: view

Pathways by source for WDR61 Gene

1 KEGG pathway for WDR61 Gene

Gene Ontology (GO) - Biological Process for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA 20178742
GO:0045638 negative regulation of myeloid cell differentiation IDA 20541477
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 20178742
genes like me logo Genes that share ontologies with WDR61: view

No data available for SIGNOR curated interactions for WDR61 Gene

Drugs & Compounds for WDR61 Gene

No Compound Related Data Available

Transcripts for WDR61 Gene

Unigene Clusters for WDR61 Gene

WD repeat domain 61:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - -
SP9: - -
SP10: - -

Relevant External Links for WDR61 Gene

GeneLoc Exon Structure for
WDR61
ECgene alternative splicing isoforms for
WDR61

Expression for WDR61 Gene

mRNA expression in normal human tissues for WDR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR61 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR61 Gene



SOURCE GeneReport for Unigene cluster for WDR61 Gene Hs.513055

genes like me logo Genes that share expression patterns with WDR61: view

Protein tissue co-expression partners for WDR61 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR61 Gene

Orthologs for WDR61 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR61 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR61 35
  • 95.3 (n)
  • 99.02 (a)
WDR61 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR61 35
  • 92.13 (n)
  • 98.36 (a)
WDR61 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr61 35
  • 92.79 (n)
  • 97.38 (a)
Wdr61 16
Wdr61 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR61 35
  • 99.67 (n)
  • 100 (a)
WDR61 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr61 35
  • 90.82 (n)
  • 97.05 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR61 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR61 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR61 35
  • 82.4 (n)
  • 93.44 (a)
WDR61 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR61 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75826 35
wdr61 35
  • 77.7 (n)
  • 85.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23922 35
zebrafish
(Danio rerio)
Actinopterygii wdr61 35
  • 76.61 (n)
  • 84.92 (a)
zgc77675 35
wdr61 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.610 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007626 35
  • 58.44 (n)
  • 56.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3909 35
  • 58.56 (n)
  • 56.67 (a)
CG3909 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F02E9.10 36
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 36
  • 17 (a)
OneToMany
SKI8 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VIP3 35
  • 51.33 (n)
  • 40.48 (a)
rice
(Oryza sativa)
Liliopsida Os11g0660300 35
  • 49.04 (n)
  • 41.36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6680 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03517 35
  • 47.84 (n)
  • 34.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rec14 35
  • 46.06 (n)
  • 33.68 (a)
Species with no ortholog for WDR61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR61 Gene

ENSEMBL:
Gene Tree for WDR61 (if available)
TreeFam:
Gene Tree for WDR61 (if available)

Paralogs for WDR61 Gene

Paralogs for WDR61 Gene

genes like me logo Genes that share paralogs with WDR61: view

Variants for WDR61 Gene

Sequence variations from dbSNP and Humsavar for WDR61 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1040262 -- 78,295,568(+) GAGCC(A/G)GGCAA intron-variant
rs876364 -- 78,291,189(-) ATGGC(A/G)TATGT intron-variant
rs1879152 -- 78,289,498(+) TCCAA(C/T)TGAGA intron-variant
rs1879153 -- 78,289,550(+) CATTT(C/T)AATGA intron-variant
rs1519820 -- 78,284,865(-) CTTGT(C/T)ATTTT intron-variant

Variation tolerance for WDR61 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR61 Gene

HapMap Linkage Disequilibrium report
WDR61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WDR61 Gene

Disorders for WDR61 Gene

Relevant External Links for WDR61

Genetic Association Database (GAD)
WDR61
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR61

No disorders were found for WDR61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR61 Gene

Publications for WDR61 Gene

  1. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. (PMID: 20178742) Kim J. … Roeder R.G. (Cell 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3

Products for WDR61 Gene

Sources for WDR61 Gene

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