Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



WDR61 Gene

protein-coding   GIFtS: 56
GCID: GC15M078575

WD Repeat Domain 61

  Search for WDR61
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
WD Repeat Domain 611 2     SKI82
Meiotic Recombination REC14 Protein Homolog2 3     Recombination Protein REC142
SKI8 Homolog2 3     WD Repeat-Containing Protein 612
REC142     Ski83

External Ids:    HGNC: 303001   Entrez Gene: 803492   Ensembl: ENSG000001403957   OMIM: 6095405   UniProtKB: Q9GZS33   

Export aliases for WDR61 gene to outside databases

Previous GC identifers: GC15M076363 GC15M055333


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for WDR61 Gene:
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are
involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 (PubMed
16024656)).(supplied by OMIM, Mar 2008)

GeneCards Summary for WDR61 Gene:
WDR61 (WD repeat domain 61) is a protein-coding gene. An important paralog of this gene is AAMP.

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA
polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.
PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and
'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and
synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for
transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional
activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins,
such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3
ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination
of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to
transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A)
factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3),
dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex
which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes
in a manner dependent on PAF1C




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR61 gene promoter:
         GR   p53   GR-beta   MIF-1   Nkx2-5   ARP-1   FOXO1a   GR-alpha   Ik-1   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR61 promoter sequence
   Search Chromatin IP Primers for WDR61

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.1   Ensembl cytogenetic band:  15q25.1   HGNC cytogenetic band: 15q25.1

WDR61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR61 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M078575:  view genomic region     (about GC identifiers)

Start:
78,570,177 bp from pter      End:
78,592,136 bp from pter
Size:
21,960 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3 (See protein sequence)
Recommended Name: WD repeat-containing protein 61  
Size: 305 amino acids; 33581 Da
Subunit: Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of
the SKI complex which consists of WDR61, SKIV2L and TTC37
1 PDB 3D structure from and Proteopedia for WDR61:
3OW8 (3D)    
Secondary accessions: D3DW84 Q6IA22 Q7Z4X4

Explore the universe of human proteins at neXtProt for WDR61: NX_Q9GZS3

Explore proteomics data for WDR61 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys97
  • Modification sites at PhosphoSitePlus

  • See WDR61 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079510.1  
    ENSEMBL proteins: 
     ENSP00000453118   ENSP00000455689   ENSP00000453801   ENSP00000267973   ENSP00000453024  
     ENSP00000453902   ENSP00000453493   ENSP00000453589  

    WDR61 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for WDR61
    OriGene Protein Over-expression Lysate for WDR61
    OriGene MassSpec for WDR61
    OriGene Custom Protein Services for WDR61
    GenScript Custom Purified and Recombinant Proteins Services for WDR61
    Novus Biologicals WDR61 Protein
    Novus Biologicals WDR61 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDR61

     
    Search eBioscience for Proteins for WDR61 

    WDR61 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for WDR61
    Novus Biologicals WDR61 Antibodies
    Abcam antibodies for WDR61
    Cloud-Clone Corp. Antibodies for WDR61
    ThermoFisher Antibodies for WDR61
    LSBio Antibodies in human, mouse, rat for WDR61

    WDR61 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for WDR61
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for WDR61
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for WDR61
    Cloud-Clone Corp. CLIAs for WDR61
    Search eBioscience for ELISAs for WDR61 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9GZS3

    ProtoNet protein and cluster: Q9GZS3

    UniProtKB/Swiss-Prot: WDR61_HUMAN, Q9GZS3
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR61           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR61_HUMAN, Q9GZS3
    Function: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA
    polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency.
    PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and
    'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and
    synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for
    transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional
    activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins,
    such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as
    ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3
    ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination
    of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to
    transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A)
    factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby
    regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3),
    dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex
    which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes
    in a manner dependent on PAF1C

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16024656
         
    Find genes that share ontologies with WDR61           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR61:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR61
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR61

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR61
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR61

    miRNA
    Products:
        
    miRTarBase miRNAs that target WDR61:
    hsa-let-7c-5p (MIRT051788), hsa-mir-221-3p (MIRT024165), hsa-mir-1301-3p (MIRT036059)

    Block miRNA regulation of human, mouse, rat WDR61 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WDR61:
    hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidWDR61 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for WDR61
    Predesigned siRNA for gene silencing in human, mouse, rat WDR61

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for WDR61

    Clone
    Products:
         
    OriGene clones in human, mouse for WDR61 (see all 7)
    OriGene ORF clones in mouse, rat for WDR61
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR61 (NM_025234)
    Sino Biological Human cDNA Clone for WDR61
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR61
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR61
    Addgene plasmids for WDR61 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for WDR61
    Browse ESI BIO Cell Lines and PureStem Progenitors for WDR61 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    WDR61_HUMAN, Q9GZS3: Nucleus. Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016593Cdc73/Paf1 complex IDA--
    GO:0035327transcriptionally active chromatin IDA16024656

    Find genes that share ontologies with WDR61           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for WDR61 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48


    Find genes that share SuperPaths with WDR61           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for WDR61):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR61
    Interactions:

        Search GeneGlobe Interaction Network for WDR61

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR61 (Q9GZS31, 2, 3 ENSP000002679734) via UniProtKB, MINT, STRING, and/or I2D (see all 126)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTR9Q6PD621, 3, ENSP000003550134EBI-358545,EBI-1019583 I2D: score=3 STRING: ENSP00000355013
    EZH2Q159102, 3MINT-64279 I2D: score=5 
    RIPK3Q9Y5722, 3MINT-49108 I2D: score=2 
    YWHAZP631042, 3, ENSP000003095034MINT-3295348 I2D: score=1 STRING: ENSP00000309503
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter IDA--
    GO:0045638negative regulation of myeloid cell differentiation IDA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--

    Find genes that share ontologies with WDR61           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR61



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for WDR61 gene: 
    NM_025234.1  

    Unigene Cluster for WDR61:

    WD repeat domain 61
    Hs.513055  [show with all ESTs]
    Unigene Representative Sequence: AK025098
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558453 ENST00000560807 ENST00000558412 ENST00000559332 ENST00000559940
    ENST00000558311(uc002bdo.3) ENST00000267973(uc002bdn.3) ENST00000558459
    ENST00000560569 ENST00000560610 ENST00000559848 ENST00000560063(uc010umz.1)
    ENST00000559700(uc010una.1) ENST00000558840 ENST00000560946 ENST00000561347(uc010blc.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat WDR61 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WDR61:
    hsa-miR-1283
    SwitchGear 3'UTR luciferase reporter plasmidWDR61 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR61
    Predesigned siRNA for gene silencing in human, mouse, rat WDR61
    Clone
    Products:
         
    OriGene clones in human, mouse for WDR61 (see all 7)
    OriGene ORF clones in mouse, rat for WDR61
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR61 (NM_025234)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR61
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR61
    Addgene plasmids for WDR61 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for WDR61
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR61
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR61
      QuantiTect SYBR Green Assays in human, mouse, rat WDR61
      QuantiFast Probe-based Assays in human, mouse, rat WDR61

    Additional mRNA sequence: 

    AF100786.1 AF127799.1 AF309553.1 AK024754.1 AK025098.2 AK300838.1 AK304617.1 AK310477.1 
    AK311320.1 AL109709.2 BC010080.2 CR457333.1 

    15 DOTS entries:

    DT.111702  DT.100816886  DT.95173113  DT.86996941  DT.91770399  DT.100816891  DT.305586  DT.97774577 
    DT.100816890  DT.40126061  DT.97769084  DT.95173112  DT.40206999  DT.91661179  DT.91770401 

    Selected AceView cDNA sequences (see all 227):

    BE302111 AW006396 BQ213470 BX090814 CR591993 BE281400 AI080120 BM926850 
    BF590110 CD514959 BQ673199 AI934724 AL526178 AA032247 BU194114 BU071329 
    BM843253 CB109379 AA312242 BI916225 CR592884 BU948164 BG030703 CR619418 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -     -           -           -           -                 -                                   -                           
    SP2:                                                        -           -                 -                                   -                           
    SP3:                                                        -     -     -     -     -     -                                   -                           
    SP4:                          -     -           -           -                             -                                                               
    SP5:                          -     -           -           -           -                                                                                 


    ECgene alternative splicing isoforms for WDR61

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    WDR61 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTATTGGA
    WDR61 Expression
    About this image


    WDR61 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    WDR61 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR61 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513055
        Custom PCR Arrays for WDR61
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for WDR61
    OriGene qSTAR qPCR primer pairs in human, mouse for WDR61
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR61
    QuantiTect SYBR Green Assays in human, mouse, rat WDR61
    QuantiFast Probe-based Assays in human, mouse, rat WDR61
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR61 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr611 , 5 WD repeat domain 611, 5 92.79(n)1
    97.38(a)1
      9 (29.73 cM)5
    663171  NM_023191.31  NP_075680.11 
     547147355 
    chicken
    (Gallus gallus)
    Aves WDR611 WD repeat domain 61 82.4(n)
    93.44(a)
      415359  NM_001005805.1  NP_001005805.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR616
    WD repeat domain 61
    88(a)
    1 ↔ 1
    GL343486.1(74738-81366)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239222 Xenopus laevis transcribed sequence with moderate similarity more 77.52(n)    BJ069622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc776752 hypothetical protein MGC77675 78.01(n)   393827  BC062834.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG39091 CG3909 58.56(n)
    56.67(a)
      41226  NM_141712.3  NP_649969.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F02E9.106
    Protein F02E9.10, isoform a (F02E9.10) mRNA, compl...
    13(a)
    1 ↔ 1
    I(8426987-8429832) WBGene00008533
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKI8(YGL213C)4 Ski complex component and WD-repeat protein, mediates more   --   7(91247-90054) 852659  NP_011302.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VIP31 VIP3 51.33(n)
    40.48(a)
      829105  NM_119129.2  NP_194712.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06603001 Os11g0660300 49.04(n)
    41.36(a)
      4351059  NM_001074935.1  NP_001068403.1 


    ENSEMBL Gene Tree for WDR61 (if available)
    TreeFam Gene Tree for WDR61 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for WDR61 gene
    AAMP2  
    Selected SIMAP similar genes for WDR61 using alignment to 7 protein entries:     WDR61_HUMAN (see all proteins) (see all similar genes):
    STRAP    WSB1    PAAF1    WSB2    GNB5    GNB2
    PF20    SMU1    KATNB1    GNB3    GNB4    TBL3
    WDR48    DAW1    GNB2L1    COPB2    POC1B    PLRG1

    Find genes that share paralogs with WDR61           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for WDR61 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71704921,2
    C,H--78575142(+) GGCTTG/CAGCCT 1 -- int116Minor allele frequency- C:0.00NS EA NA WA CSA 549
    rs1915119881,2
    --78575186(+) CCTTCC/TGATAC 1 -- int10--------
    rs1460890211,2
    C--78575273(+) AGTGG-/AAAGGA 1 -- int10--------
    rs1833855951,2
    --78575280(+) AGGATA/GCCCAG 1 -- int10--------
    rs1480703211,2
    --78575313(+) CCTATA/GCAGTC 1 -- int10--------
    rs1157041841,2
    F--78575316(+) ATGCAG/ATCAAA 1 -- int11Minor allele frequency- A:0.04WA 118
    rs1863390671,2
    --78575338(+) CTTCAA/GGACTC 1 -- int10--------
    rs595647711,2
    C,F--78575379(+) AGCTCC/TGGGGA 1 -- int14Minor allele frequency- T:0.17WA CSA 123
    rs1146544241,2
    F--78575393(+) CGCTGC/TTGTAT 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1900109021,2
    --78575585(+) GCATTA/CAGAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR61 (78570177 - 78592136 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WDR61: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR61
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR61

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609540    OMIM disorders: --


    Find genes that share disorders with WDR61           About GenesLikeMe

    Genetic Association Database (GAD): WDR61

    Export disorders for WDR61 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for WDR61 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with WDR61)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. (PubMed id 20178742)1, 2 Kim J.... Roeder R.G. (Cell 2010)
    2. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PubMed id 16024656)1, 2 Zhu B.... Reinberg D. (Genes Dev. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. OTUB1 modulates c-IAP1 stability to regulate signalling pathways. (PubMed id 23524849)1 Goncharov T....Vucic D. (EMBO J. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription. (PubMed id 22451921)1 Wu J. and Xu W. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 80349 HGNC: 30300 AceView: REC14 Ensembl:ENSG00000140395 euGenes: HUgn80349
    ECgene: WDR61 Kegg: 80349 H-InvDB: WDR61

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for WDR61 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for WDR61 gene:
    Search GeneIP for patents involving WDR61

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for WDR61  
     OriGene qPCR primer pairs and template standards for WDR61   OriGene Protein Over-expression Lysate for WDR61  
     OriGene MassSpec something-or-other for WDR61   OriGene clones in human, mouse for WDR61  
     OriGene qSTAR qPCR primer pairs in human, mouse for WDR61   OriGene Purified Protein for WDR61  
     OriGene ORF clones in mouse, rat for WDR61   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for WDR61   OriGene Custom Protein Services for WDR61  

     
     
     Block miRNA regulation of human, mouse, rat WDR61 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing WDR61
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR61 Predesigned siRNA for gene silencing in human, mouse, rat WDR61
     QuantiFast Probe-based Assays in human, mouse, rat WDR61 QuantiTect SYBR Green Assays in human, mouse, rat WDR61
     Custom PCR Arrays for WDR61 Search Chromatin IP Primers for WDR61
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR61  Search GeneGlobe Interaction Network for WDR61
     Regulatory tfbs in WDR61 promoter
     GenScript Custom Purified and Recombinant Proteins Services for WDR61 GenScript cDNA clones with any tag delivered in your preferred vector for WDR61
     GenScript Custom Assay Services for WDR61 GenScript Custom overexpressing Cell Line Services for WDR61
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for WDR61
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for WDR61
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     WDR61 antibodies
     WDR61 proteins
     WDR61 lysates
     Antibodies for WDR61
     See all of Abcam's Antibodies, Kits and Proteins for WDR61
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for WDR61
     Antibodies for WDR61
     ELISAs for WDR61
     CLIAs for WDR61



     Browse ESI BIO Cell Lines and PureStem Progenitors for WDR61
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR61
     SwitchGear 3'UTR luciferase reporter plasmids for WDR61
     SwitchGear Promoter luciferase reporter plasmids for WDR61
     ThermoFisher Antibodies for WDR61
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR61
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR61
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR61
     LSBio Antibodies in human, mouse, rat for WDR61
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for WDR61
      Search eBioscience for proteins for WDR61
      Search eBioscience for elisas for WDR61
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      WDR61 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4