Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR61 Gene

Aliases for WDR61 Gene

  • WD Repeat Domain 61 2 3 5
  • Meiotic Recombination REC14 Protein Homolog 3 4
  • SKI8 Homolog 3 4
  • SKI8 3 4
  • WD Repeat-Containing Protein 61 3
  • Recombination Protein REC14 3
  • REC14 3

External Ids for WDR61 Gene

Previous GeneCards Identifiers for WDR61 Gene

  • GC15M076363
  • GC15M078575
  • GC15M055333

Summaries for WDR61 Gene

Entrez Gene Summary for WDR61 Gene

  • WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]

GeneCards Summary for WDR61 Gene

WDR61 (WD Repeat Domain 61) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. An important paralog of this gene is NLE1.

UniProtKB/Swiss-Prot for WDR61 Gene

  • Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3), dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR61 Gene

Genomics for WDR61 Gene

Regulatory Elements for WDR61 Gene

Enhancers for WDR61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G077621 1.2 ENCODE dbSUPER 37.4 +676.9 676890 2.7 HDGF ZNF133 GLI4 ZNF2 ZBTB7B TCF12 ZNF207 MCM3 ZNF488 SMARCB1 ENSG00000259562 WDR61 ENSG00000259322 IREB2 ENSG00000260988 TBC1D2B HYKK LOC645752 HMG20A ENSG00000269951
GH15G078242 1.2 Ensembl ENCODE 29 +56.3 56256 2.7 CBX3 ZNF473 ZSCAN4 RAD21 ZEB1 ZNF766 GATA2 ZNF416 IKZF2 ZNF114 WDR61 ENSG00000259322 ENSG00000259562 HYKK LOC105370911 ACSBG1 DNAJA4 PIR40151 PIR56006
GH15G078417 0.9 ENCODE 21 -119.2 -119190 2.1 SREBF2 ZFP64 GLI4 RARA FOS SP3 ZNF680 SP5 USF2 CEBPB ENSG00000259562 IREB2 WDR61 TBC1D2B CRABP1 CHRNA5 PSMA4 RWDD1P1 ENSG00000259413
GH15G077884 1.5 Ensembl ENCODE dbSUPER 11.7 +414.4 414393 1.2 HDGF YBX1 GLI4 ZNF2 ZBTB7B GLIS2 ZNF143 ZNF207 ZNF548 ZNF263 ENSG00000259562 IREB2 ENSG00000259322 TBC1D2B WDR61 LOC645752 CSPG4P13 DNM1P9
GH15G078453 1.4 Ensembl ENCODE dbSUPER 10.4 -155.7 -155659 4.5 PKNOX1 CREB3L1 NFIB INSM2 SIN3A FEZF1 ZNF121 ZNF366 ZSCAN5C SCRT2 PSMA4 IREB2 WDR61 CRABP1 ENSG00000259474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR61 on UCSC Golden Path with GeneCards custom track

Promoters for WDR61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079721 126 1601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for WDR61 Gene

Chromosome:
15
Start:
78,277,835 bp from pter
End:
78,299,794 bp from pter
Size:
21,960 bases
Orientation:
Minus strand

Genomic View for WDR61 Gene

Genes around WDR61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR61 Gene

Proteins for WDR61 Gene

  • Protein details for WDR61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS3-WDR61_HUMAN
    Recommended name:
    WD repeat-containing protein 61
    Protein Accession:
    Q9GZS3
    Secondary Accessions:
    • D3DW84
    • Q6IA22
    • Q7Z4X4

    Protein attributes for WDR61 Gene

    Size:
    305 amino acids
    Molecular mass:
    33581 Da
    Quaternary structure:
    • Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Component of the SKI complex which consists of WDR61, SKIV2L and TTC37.

    Three dimensional structures from OCA and Proteopedia for WDR61 Gene

neXtProt entry for WDR61 Gene

Post-translational modifications for WDR61 Gene

  • Ubiquitination at posLast=4545 and isoforms=97
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR61 Gene

Domains & Families for WDR61 Gene

Suggested Antigen Peptide Sequences for WDR61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR61: view

No data available for UniProtKB/Swiss-Prot for WDR61 Gene

Function for WDR61 Gene

Molecular function for WDR61 Gene

UniProtKB/Swiss-Prot Function:
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys-4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 Lys-4 (H3K4me3), dimethylation on histone H3 Lys-79 (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C.

Gene Ontology (GO) - Molecular Function for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16024656
genes like me logo Genes that share ontologies with WDR61: view
genes like me logo Genes that share phenotypes with WDR61: view

Animal Model Products

CRISPR Products

miRNA for WDR61 Gene

miRTarBase miRNAs that target WDR61

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR61

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR61 Gene

Localization for WDR61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR61 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR61 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16024656
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IDA,IEA 16024656
GO:0005829 cytosol IDA,TAS --
GO:0016593 Cdc73/Paf1 complex IDA 20178742
genes like me logo Genes that share ontologies with WDR61: view

Pathways & Interactions for WDR61 Gene

genes like me logo Genes that share pathways with WDR61: view

Gene Ontology (GO) - Biological Process for WDR61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with WDR61: view

No data available for SIGNOR curated interactions for WDR61 Gene

Transcripts for WDR61 Gene

Unigene Clusters for WDR61 Gene

WD repeat domain 61:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR61

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR61 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - -
SP9: - -
SP10: - -

Relevant External Links for WDR61 Gene

GeneLoc Exon Structure for
WDR61
ECgene alternative splicing isoforms for
WDR61

Expression for WDR61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR61 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR61 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR61 Gene



Protein tissue co-expression partners for WDR61 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR61 Gene:

WDR61

SOURCE GeneReport for Unigene cluster for WDR61 Gene:

Hs.513055

Evidence on tissue expression from TISSUES for WDR61 Gene

  • Liver(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with WDR61: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR61 Gene

Orthologs for WDR61 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR61 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia WDR61 34 35
  • 95.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR61 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr61 34 16 35
  • 92.79 (n)
dog
(Canis familiaris)
Mammalia WDR61 34 35
  • 92.13 (n)
rat
(Rattus norvegicus)
Mammalia Wdr61 34
  • 90.82 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR61 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR61 34 35
  • 82.4 (n)
lizard
(Anolis carolinensis)
Reptilia WDR61 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr61 34
  • 77.7 (n)
MGC75826 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23922 34
zebrafish
(Danio rerio)
Actinopterygii wdr61 34 35
  • 76.61 (n)
zgc77675 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.610 34
fruit fly
(Drosophila melanogaster)
Insecta CG3909 34 35
  • 58.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007626 34
  • 58.44 (n)
worm
(Caenorhabditis elegans)
Secernentea F02E9.10 35
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 35
  • 17 (a)
OneToMany
SKI8 37
thale cress
(Arabidopsis thaliana)
eudicotyledons VIP3 34
  • 51.33 (n)
rice
(Oryza sativa)
Liliopsida Os11g0660300 34
  • 49.04 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03517 34
  • 47.84 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rec14 34
  • 46.06 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6680 34
Species where no ortholog for WDR61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR61 Gene

ENSEMBL:
Gene Tree for WDR61 (if available)
TreeFam:
Gene Tree for WDR61 (if available)

Paralogs for WDR61 Gene

Paralogs for WDR61 Gene

genes like me logo Genes that share paralogs with WDR61: view

Variants for WDR61 Gene

Sequence variations from dbSNP and Humsavar for WDR61 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000105138 -- 78,291,310(+) CCAAG(A/G)TGAAA intron-variant
rs1000181659 -- 78,298,357(+) TTTTA(A/G)GTAAT intron-variant
rs1000304198 -- 78,297,585(+) TATCA(C/T)GATAT intron-variant
rs1000362330 -- 78,291,884(+) GGTTC(C/T)GCTGG intron-variant
rs1000688443 -- 78,284,382(+) ATAAG(A/C)ATGAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WDR61 Gene

Variant ID Type Subtype PubMed ID
nsv1116464 OTHER inversion 24896259

Variation tolerance for WDR61 Gene

Residual Variation Intolerance Score: 25.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR61 Gene

Disorders for WDR61 Gene

Relevant External Links for WDR61

Genetic Association Database (GAD)
WDR61
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR61

No disorders were found for WDR61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR61 Gene

Publications for WDR61 Gene

  1. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. (PMID: 20178742) Kim J. … Roeder R.G. (Cell 2010) 3 4 64
  2. The human PAF complex coordinates transcription with events downstream of RNA synthesis. (PMID: 16024656) Zhu B. … Reinberg D. (Genes Dev. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for WDR61 Gene

Sources for WDR61 Gene

Content
Loading form....