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WDR6 Gene

protein-coding   GIFtS: 50
GCID: GC03P049044

WD Repeat Domain 6

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 61 2
WD Repeat-Containing Protein 62

External Ids:    HGNC: 127581   Entrez Gene: 111802   Ensembl: ENSG000001782527   OMIM: 6060315   UniProtKB: Q9NNW53   

Export aliases for WDR6 gene to outside databases

Previous GC identifers: GC15U990073 GC03P048192 GC03P048899 GC03P049003 GC03P049019


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR6 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and
is implicated in cell growth arrest. (provided by RefSeq, Aug 2008)

GeneCards Summary for WDR6 Gene:
WDR6 (WD repeat domain 6) is a protein-coding gene. Diseases associated with WDR6 include peutz-jeghers syndrome. GO annotations related to this gene include insulin receptor substrate binding.

UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid
starvation-induced autophagy

Gene Wiki entry for WDR6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR6 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   Pax-6   Lmo2   Olf-1   CUTL1   AREB6   ARP-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR6 promoter sequence
   Search Chromatin IP Primers for WDR6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

WDR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049044:  view genomic region     (about GC identifiers)

Start:
49,044,495 bp from pter      End:
49,053,386 bp from pter
Size:
8,892 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5 (See protein sequence)
Recommended Name: WD repeat-containing protein 6  
Size: 1121 amino acids; 121725 Da
Subunit: Interacts with IRS4 (By similarity). Interacts with STK11/LKB1
Sequence caution: Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DHK2 Q3MIT1 Q9UF63

Explore the universe of human proteins at neXtProt for WDR6: NX_Q9NNW5

Explore proteomics data for WDR6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys237, Lys343, Lys418, Lys437, Lys490, Lys526, Lys708, Lys855, Lys910, Lys915
  • Modification sites at PhosphoSitePlus

  • See WDR6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060501.3  
    ENSEMBL proteins: 
     ENSP00000378857   ENSP00000477418   ENSP00000427893   ENSP00000477233   ENSP00000477294  
     ENSP00000387692   ENSP00000477389   ENSP00000412195   ENSP00000414157   ENSP00000395993  
     ENSP00000413432   ENSP00000390740   ENSP00000477087   ENSP00000477463  

    WDR6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for WDR6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR011043 Gal_Oxase/kelch_b-propeller
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NNW5

    ProtoNet protein and cluster: Q9NNW5

    UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
    Similarity: Belongs to the WD repeat WDR6 family
    Similarity: Contains 16 WD repeats


    WDR6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR6_HUMAN, Q9NNW5
    Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid
    starvation-induced autophagy

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17216128
    GO:0043560insulin receptor substrate binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    WDR6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR6

    miRNA
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    miRTarBase miRNAs that target WDR6:
    hsa-mir-197-3p (MIRT003823), hsa-mir-425-5p (MIRT039347), hsa-mir-222-3p (MIRT046727), hsa-mir-107 (MIRT048308), hsa-let-7a-5p (MIRT052587), hsa-mir-615-3p (MIRT040119), hsa-mir-92a-3p (MIRT049150), hsa-mir-760 (MIRT036730)

    Block miRNA regulation of human, mouse, rat WDR6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate WDR6:
    hsa-miR-873 hsa-miR-3120-3p hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidWDR6 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR6

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    GenScript: all cDNA clones in your preferred vector: WDR6 (NM_018031)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR6_HUMAN, Q9NNW5: Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0043234protein complex ----

    WDR6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR6
    Interactions:

        GeneGlobe Interaction Network for WDR6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for WDR6 (Q9NNW51, 2, 3 ENSP000003788574) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STK11Q158311, 3, ENSP000003248564EBI-1568315,EBI-306838 I2D: score=1 STRING: ENSP00000324856
    CDC42EP4Q9H3Q12, 3, ENSP000003382584MINT-66544 I2D: score=4 STRING: ENSP00000338258
    G2E3Q7L6222, 3, ENSP000002065954MINT-68270 I2D: score=4 STRING: ENSP00000206595
    CHMP4AQ9BY433, ENSP000003242054I2D: score=1 STRING: ENSP00000324205
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IDA17216128
    GO:0008285negative regulation of cell proliferation IDA17216128
    GO:0010507negative regulation of autophagy IMP--

    WDR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for WDR6 gene: 
    NM_018031.3  

    Unigene Cluster for WDR6:

    WD repeat domain 6
    Hs.654815  [show with all ESTs]
    Unigene Representative Sequence: NM_018031
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000395474(uc011bbx.1 uc003cvj.2 uc011bby.1 uc010hkn.2 uc011bbz.1)
    ENST00000429900 ENST00000488572 ENST00000462064 ENST00000489684 ENST00000473238
    ENST00000438660 ENST00000608424 ENST00000415265 ENST00000452875 ENST00000420783
    ENST00000471162 ENST00000472878 ENST00000448293 ENST00000419837 ENST00000461687
    ENST00000489427 ENST00000491365
    miRNA
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    Block miRNA regulation of human, mouse, rat WDR6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate WDR6:
    hsa-miR-873 hsa-miR-3120-3p hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidWDR6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for WDR6
    Predesigned siRNA for gene silencing in human, mouse, rat WDR6
    Clone
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    OriGene ORF clones in mouse, rat for WDR6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: WDR6 (NM_018031)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for WDR6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR6
      QuantiTect SYBR Green Assays in human, mouse, rat WDR6
      QuantiFast Probe-based Assays in human, mouse, rat WDR6

    Additional mRNA sequence: 

    AF099100.1 AK001080.1 AK022719.1 AK092079.1 AK295145.1 AK296387.1 AK297090.1 AK304117.1 
    AL133589.1 AL833910.1 BC002826.2 BC078176.1 BC101707.1 BC113467.1 BC143486.1 BC143488.1 

    Selected DOTS entries (see all 45):

    DT.91932300  DT.100646769  DT.95259800  DT.120852477  DT.100644682  DT.419405  DT.120852406  DT.86836253 
    DT.99989441  DT.97791419  DT.97861932  DT.120852556  DT.100646764  DT.92437664  DT.120852620  DT.40107524 
    DT.120852699  DT.95176872  DT.95259866  DT.97861933  DT.120852549  DT.100646770  DT.100871177  DT.120852412 

    Selected AceView cDNA sequences (see all 508):

    BQ231496 CA406250 BU148480 BI257586 BM563249 AI816982 CD513672 BM706327 
    BQ058346 AI921151 AL522846 BG818746 BM831849 BG774063 BU902491 BG761650 
    BM821745 AW129925 AA377891 BQ893309 BU957103 AJ705561 BM718832 BU169511 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                                                                                                    
    SP2:                                -     -           -                                                                                 
    SP3:                          -                 -     -                                                                                 
    SP4:                          -     -     -     -     -                       -                                                         
    SP5:                          -           -     -     -                                                                                 


    ECgene alternative splicing isoforms for WDR6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR6 expression in normal human tissues (normalized intensities)      WDR6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGCTGTA
    WDR6 Expression
    About this image


    WDR6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    WDR6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654815

    UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for WDR6
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    QuantiFast Probe-based Assays in human, mouse, rat WDR6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WDR6 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr61 , 5 WD repeat domain 61, 5 84.15(n)1
    86.8(a)1
      9 (59.51 cM)5
    836691  NM_031392.21  NP_113569.11 
     1085723135 
    chicken
    (Gallus gallus)
    Aves WDR61 WD repeat domain 6 56.62(n)
    49.11(a)
      416060  XM_003642012.2  XP_003642060.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR66
    WD repeat domain 6
    45(a)
    1 ↔ 1
    2(187826959-187836896)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX774647.12   -- 71.93(n)    BX774647.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr61 WD repeat domain 6 48.98(n)
    38.95(a)
      100004270  NM_001113654.1  NP_001107126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG331721 CG33172 41.92(n)
    28.81(a)
      32526  NM_176738.2  NP_788911.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RTT101 RTT10 38.67(n)
    24.71(a)
      855919   NP_015142.1 


    ENSEMBL Gene Tree for WDR6 (if available)
    TreeFam Gene Tree for WDR6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR6 gene
    Selected SIMAP similar genes for WDR6 using alignment to 13 protein entries:     WDR6_HUMAN (see all proteins) (see all similar genes):
    DKFZp434F1720    COX7A2    ZNF568    NSRP1    TGFBR3    THADA
    ZNF415    ZNF738    ZNHIT3    ZNF83    SUN3    ATL2
    C19orf47    CNOT2    DAPK2    ECD    FANCA    HGSNAT

    WDR6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR6 (see all 363)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1921010291,2
    --48975074(+) CCTGTC/GAAGCC 1 -- us2k10--------
    rs1829151631,2
    --48975077(+) GTCAAC/GCCAGT 1 -- us2k10--------
    rs1872661181,2
    --48975254(+) ACTCAC/TAGTAA 1 -- us2k10--------
    rs1917830511,2
    --48975283(+) AGGAGA/GGGCTA 1 -- us2k10--------
    rs2017677441,2
    C--48975430(+) CCCCCA/CCTGCC 1 -- us2k10--------
    rs1442795281,2
    C,F--48975524(+) CCTACG/AATGAA 1 -- us2k11Minor allele frequency- A:0.00NA 4550
    rs1382466261,2
    --48975691(+) GAGTGA/GGGACA 1 -- us2k10--------
    rs1999725761,2
    --48975765(+) ACACAC/TGGAGG 1 -- us2k10--------
    rs76242251,2
    C,H--48975773(+) AGGCAC/TTGTGA 1 -- us2k16Minor allele frequency- T:0.00NS EA NA 420
    rs788759831,2
    C--48975820(+) AGCAGC/TCTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WDR6 (49044495 - 49053386 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876764CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606031    OMIM disorders: --

    1 disease for WDR6:    About MalaCards
    peutz-jeghers syndrome

    1 disease from the University of Copenhagen DISEASES database for WDR6:
    Peutz-Jeghers syndrome

    WDR6 for disorders           About GeneDecksing


    Export disorders for WDR6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR6 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with WDR6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PubMed id 17216128)1, 2 Xie X.... Chen Y. (Mol. Cell. Biochem. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PubMed id 10903905)1, 2 Li D.... Roberts R. (Biochem. Biophys. Res. Commun. 2000)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (EMBO J. 2012)
    10. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11180 HGNC: 12758 AceView: WDR6 Ensembl:ENSG00000178252 euGenes: HUgn11180
    ECgene: WDR6 H-InvDB: WDR6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WDR6 gene:
    Search GeneIP for patents involving WDR6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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