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Aliases for WDR6 Gene

Aliases for WDR6 Gene

  • WD Repeat Domain 6 2 3

External Ids for WDR6 Gene

Summaries for WDR6 Gene

Entrez Gene Summary for WDR6 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. [provided by RefSeq, Aug 2008]

GeneCards Summary for WDR6 Gene

WDR6 (WD Repeat Domain 6) is a Protein Coding gene. GO annotations related to this gene include insulin receptor substrate binding.

UniProtKB/Swiss-Prot for WDR6 Gene

  • Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for WDR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR6 Gene

Genomics for WDR6 Gene

Genomic Location for WDR6 Gene

Start:
49,007,062 bp from pter
End:
49,015,953 bp from pter
Size:
8,892 bases
Orientation:
Plus strand

Genomic View for WDR6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR6 Gene

Regulatory Elements for WDR6 Gene

Proteins for WDR6 Gene

  • Protein details for WDR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNW5-WDR6_HUMAN
    Recommended name:
    WD repeat-containing protein 6
    Protein Accession:
    Q9NNW5
    Secondary Accessions:
    • B4DHK2
    • Q3MIT1
    • Q9UF63

    Protein attributes for WDR6 Gene

    Size:
    1121 amino acids
    Molecular mass:
    121725 Da
    Quaternary structure:
    • Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.
    SequenceCaution:
    • Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR6 Gene

Proteomics data for WDR6 Gene at MOPED

Post-translational modifications for WDR6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys237, Lys343, Lys418, Lys437, Lys490, Lys526, Lys708, Lys855, Lys910, and Lys915

No data available for DME Specific Peptides for WDR6 Gene

Domains for WDR6 Gene

Gene Families for WDR6 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR6 Gene

UniProtKB/Swiss-Prot:

WDR6_HUMAN
Family:
  • Belongs to the WD repeat WDR6 family.:
    • Q9NNW5
Similarity:
  • Contains 16 WD repeats.:
    • Q9NNW5
genes like me logo Genes that share domains with WDR6: view

Function for WDR6 Gene

Molecular function for WDR6 Gene

UniProtKB/Swiss-Prot Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17216128
GO:0043560 insulin receptor substrate binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR6 Gene

Localization for WDR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR6 Gene

Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR6 Gene COMPARTMENTS Subcellular localization image for WDR6 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with WDR6: view

Pathways for WDR6 Gene

SuperPathways for WDR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IDA 17216128
GO:0008285 negative regulation of cell proliferation IDA 17216128
GO:0010507 negative regulation of autophagy IMP 22354037
genes like me logo Genes that share ontologies with WDR6: view

No data available for Pathways by source for WDR6 Gene

Transcripts for WDR6 Gene

Unigene Clusters for WDR6 Gene

WD repeat domain 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8: - - -

Relevant External Links for WDR6 Gene

GeneLoc Exon Structure for
WDR6
ECgene alternative splicing isoforms for
WDR6

Expression for WDR6 Gene

mRNA expression in normal human tissues for WDR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR6 Gene

SOURCE GeneReport for Unigene cluster for WDR6 Gene Hs.654815

mRNA Expression by UniProt/SwissProt for WDR6 Gene

Q9NNW5-WDR6_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with WDR6: view

Orthologs for WDR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR6 36
  • 98.74 (n)
  • 98.01 (a)
WDR6 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR6 36
  • 86.82 (n)
  • 90.43 (a)
WDR6 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR6 36
  • 89.13 (n)
  • 93.57 (a)
WDR6 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr6 36
  • 84.15 (n)
  • 86.8 (a)
Wdr6 16
Wdr6 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR6 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR6 37
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr6 36
  • 85.34 (n)
  • 88.76 (a)
chicken
(Gallus gallus)
Aves WDR6 36
  • 56.62 (n)
  • 49.11 (a)
WDR6 37
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR6 37
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr6 36
  • 52.5 (n)
  • 44.56 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr6 36
  • 48.98 (n)
  • 38.95 (a)
wdr6 37
  • 33 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004545 36
  • 41.21 (n)
  • 29.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33172 36
  • 41.92 (n)
  • 28.81 (a)
CG33172 37
  • 22 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL056C 36
  • 42.43 (n)
  • 28.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT10 36
  • 38.67 (n)
  • 24.71 (a)
RTT10 37
  • 20 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18899g 36
  • 37.29 (n)
  • 24.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07492 36
  • 41.1 (n)
  • 28.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1306.02 36
  • 38.76 (n)
  • 26.67 (a)
Species with no ortholog for WDR6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR6 Gene

ENSEMBL:
Gene Tree for WDR6 (if available)
TreeFam:
Gene Tree for WDR6 (if available)

Paralogs for WDR6 Gene

genes like me logo Genes that share paralogs with WDR6: view

No data available for Paralogs for WDR6 Gene

Variants for WDR6 Gene

Sequence variations from dbSNP and Humsavar for WDR6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11540500 -- 49,013,595(+) GGTGG(C/T)TGCAC reference, synonymous-codon
rs12330654 -- 49,009,126(+) attcg(A/C)ctgcc intron-variant
rs12637996 -- 49,011,958(+) TATAT(A/G)ACCCT missense, reference
rs13316620 -- 49,007,922(+) CGAGC(C/T)GGGGG intron-variant
rs17357535 -- 49,011,644(+) GGGTC(C/T)CGATG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR6 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Relevant External Links for WDR6 Gene

HapMap Linkage Disequilibrium report
WDR6

Disorders for WDR6 Gene

(1) University of Copenhagen DISEASES for WDR6 Gene

genes like me logo Genes that share disorders with WDR6: view

No data available for UniProtKB/Swiss-Prot for WDR6 Gene

Publications for WDR6 Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4
  2. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PMID: 17216128) Xie X. … Chen Y. (Mol. Cell. Biochem. 2007) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PMID: 10903905) Li D. … Roberts R. (Biochem. Biophys. Res. Commun. 2000) 3 4

Products for WDR6 Gene

Sources for WDR6 Gene

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