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Aliases for WDR6 Gene

Aliases for WDR6 Gene

  • WD Repeat Domain 6 2 3 5

External Ids for WDR6 Gene

Previous GeneCards Identifiers for WDR6 Gene

  • GC15U990073
  • GC03P048192
  • GC03P048899
  • GC03P049003
  • GC03P049019
  • GC03P049044

Summaries for WDR6 Gene

Entrez Gene Summary for WDR6 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for WDR6 Gene

WDR6 (WD Repeat Domain 6) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and insulin receptor substrate binding.

UniProtKB/Swiss-Prot for WDR6 Gene

  • Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for WDR6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR6 Gene

Genomics for WDR6 Gene

Regulatory Elements for WDR6 Gene

Promoters for WDR6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR6 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR6 Gene

Chromosome:
3
Start:
49,007,062 bp from pter
End:
49,015,953 bp from pter
Size:
8,892 bases
Orientation:
Plus strand

Genomic View for WDR6 Gene

Genes around WDR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR6 Gene

Proteins for WDR6 Gene

  • Protein details for WDR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNW5-WDR6_HUMAN
    Recommended name:
    WD repeat-containing protein 6
    Protein Accession:
    Q9NNW5
    Secondary Accessions:
    • B4DHK2
    • Q3MIT1
    • Q9UF63

    Protein attributes for WDR6 Gene

    Size:
    1121 amino acids
    Molecular mass:
    121725 Da
    Quaternary structure:
    • Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.
    SequenceCaution:
    • Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR6 Gene

Proteomics data for WDR6 Gene at MOPED

Post-translational modifications for WDR6 Gene

  • Ubiquitination at Lys 237, Lys 343, Lys 418, Lys 437, Lys 490, Lys 526, Lys 708, Lys 855, Lys 910, and Lys 915
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR6 Gene

Domains & Families for WDR6 Gene

Gene Families for WDR6 Gene

Protein Domains for WDR6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NNW5

UniProtKB/Swiss-Prot:

WDR6_HUMAN :
  • Belongs to the WD repeat WDR6 family.
  • Contains 16 WD repeats.
Family:
  • Belongs to the WD repeat WDR6 family.
Similarity:
  • Contains 16 WD repeats.
genes like me logo Genes that share domains with WDR6: view

Function for WDR6 Gene

Molecular function for WDR6 Gene

UniProtKB/Swiss-Prot Function:
Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Animal Model Products

  • Taconic Biosciences Mouse Models for WDR6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR6 Gene

Localization for WDR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR6 Gene

Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR6 Gene COMPARTMENTS Subcellular localization image for WDR6 gene
Compartment Confidence
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for WDR6 Gene

Pathways & Interactions for WDR6 Gene

SuperPathways for WDR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR6 Gene

Drugs & Compounds for WDR6 Gene

No Compound Related Data Available

Transcripts for WDR6 Gene

Unigene Clusters for WDR6 Gene

WD repeat domain 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8: - - -

Relevant External Links for WDR6 Gene

GeneLoc Exon Structure for
WDR6
ECgene alternative splicing isoforms for
WDR6

Expression for WDR6 Gene

mRNA expression in normal human tissues for WDR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR6 Gene

This gene is overexpressed in Plasma (33.5), Lung (6.6), Skin (6.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR6 Gene



SOURCE GeneReport for Unigene cluster for WDR6 Gene Hs.654815

mRNA Expression by UniProt/SwissProt for WDR6 Gene

Q9NNW5-WDR6_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with WDR6: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for WDR6 Gene

Orthologs for WDR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR6 36
  • 97 (a)
OneToOne
WDR6 35
  • 98.74 (n)
  • 98.01 (a)
cow
(Bos Taurus)
Mammalia WDR6 36
  • 90 (a)
OneToOne
WDR6 35
  • 86.82 (n)
  • 90.43 (a)
dog
(Canis familiaris)
Mammalia WDR6 35
  • 89.13 (n)
  • 93.57 (a)
WDR6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr6 16
Wdr6 36
  • 86 (a)
OneToOne
Wdr6 35
  • 84.15 (n)
  • 86.8 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR6 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR6 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr6 35
  • 85.34 (n)
  • 88.76 (a)
chicken
(Gallus gallus)
Aves WDR6 36
  • 47 (a)
OneToOne
WDR6 35
  • 56.62 (n)
  • 49.11 (a)
lizard
(Anolis carolinensis)
Reptilia WDR6 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr6 35
  • 52.5 (n)
  • 44.56 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr6 36
  • 33 (a)
OneToOne
wdr6 35
  • 48.98 (n)
  • 38.95 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004545 35
  • 41.21 (n)
  • 29.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33172 36
  • 22 (a)
OneToOne
CG33172 35
  • 41.92 (n)
  • 28.81 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL056C 35
  • 42.43 (n)
  • 28.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT10 35
  • 38.67 (n)
  • 24.71 (a)
RTT10 36
  • 20 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18899g 35
  • 37.29 (n)
  • 24.41 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07492 35
  • 41.1 (n)
  • 28.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1306.02 35
  • 38.76 (n)
  • 26.67 (a)
Species with no ortholog for WDR6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR6 Gene

ENSEMBL:
Gene Tree for WDR6 (if available)
TreeFam:
Gene Tree for WDR6 (if available)

Paralogs for WDR6 Gene

genes like me logo Genes that share paralogs with WDR6: view

No data available for Paralogs for WDR6 Gene

Variants for WDR6 Gene

Sequence variations from dbSNP and Humsavar for WDR6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11540500 -- 49,013,595(+) GGTGG(C/T)TGCAC nc-transcript-variant, reference, synonymous-codon
rs12330654 -- 49,009,126(+) attcg(A/C)ctgcc intron-variant
rs62262473 -- 49,011,962(+) TGACC(C/T)TGTAG nc-transcript-variant, reference, missense
rs61746960 -- 49,012,912(+) CTGGC(A/G)GGGTA nc-transcript-variant, reference, missense
rs75976751 -- 49,014,168(+) TCCCA(C/G)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR6 Gene

Variant ID Type Subtype PubMed ID
nsv876764 CNV Loss 21882294

Variation tolerance for WDR6 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR6 Gene

HapMap Linkage Disequilibrium report
WDR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR6 Gene

Disorders for WDR6 Gene

Relevant External Links for WDR6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR6

No disorders were found for WDR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR6 Gene

Publications for WDR6 Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for WDR6 Gene

Sources for WDR6 Gene

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