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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR6 Gene

protein-coding   GIFtS: 47
GCID: GC03P049044

WD repeat domain 6

 Explore 1 disease affiliated with
WDR6 via our new
 Human Malady Compendium 
Biological research products
for WDR6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
WD Repeat Domain 61 2
WD Repeat-Containing Protein 62

External Ids:    HGNC: 127581   Entrez Gene: 111802   Ensembl: ENSG000001782527   OMIM: 6060315   UniProtKB: Q9NNW53   

Export aliases for WDR6 gene to outside databases

Previous GC identifers: GC15U990073 GC03P048192 GC03P048899 GC03P049003 GC03P049019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR6:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately
40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or
multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell
growth arrest. (provided by RefSeq, Aug 2008)

UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid
starvation-induced autophagy

Gene Wiki entry for WDR6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR6 gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   Pax-6   Lmo2   Olf-1   CUTL1   AREB6   ARP-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR6 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

WDR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049044:  view genomic region     (about GC identifiers)

Start:
49,044,495 bp from pter      End:
49,053,386 bp from pter
Size:
8,892 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5 (See protein sequence)
Recommended Name: WD repeat-containing protein 6  
Size: 1121 amino acids; 121725 Da
Subunit: Interacts with IRS4 (By similarity). Interacts with STK11/LKB1
Subcellular location: Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1
Sequence caution: Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DHK2 Q3MIT1 Q9UF63

Explore the universe of human proteins at neXtProt for WDR6: NX_Q9NNW5

WDR6 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_060501.3  
ENSEMBL proteins: 
 ENSP00000378857   ENSP00000427893   ENSP00000387692   ENSP00000412195   ENSP00000414157  
 ENSP00000395993   ENSP00000413432   ENSP00000390740  

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Uscn Proteins for WDR6

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005625soluble fraction ----
GO:0005737cytoplasm IDA--
GO:0008180colocalizes with signalosome IDA18850735
GO:0043234protein complex ----


WDR6 for ontologies           About GeneDecksing



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Uscn ELISAs and CLIAs for WDR6


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR6 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_dom
 IPR015943 WD40/YVTN_repeat-like_dom
 IPR011044 Quino_amine_DH_bsu

Graphical View of Domain Structure for InterPro Entry Q9NNW5

ProtoNet protein and cluster: Q9NNW5

UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
Similarity: Belongs to the WD repeat WDR6 family
Similarity: Contains 16 WD repeats


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid
starvation-induced autophagy

miRNA
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3 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR6:
hsa-miR-873 hsa-miR-3120-3p hsa-miR-1324
SwitchGear 3'UTR luciferase reporter plasmidWDR6 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI17216128
GO:0043560insulin receptor substrate binding IEA--


WDR6 for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDR6

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/61 Interacting proteins for WDR6 (Q9NNW51, 2, 3 ENSP000003788574) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
InteractantInteraction Details
GeneCardExternal ID(s)
STK11Q158311, 3, ENSP000003248564EBI-1568315,EBI-306838 I2D: score=1 STRING: ENSP00000324856
CDC42EP4Q9H3Q12, 3, ENSP000003382584MINT-66544 I2D: score=4 STRING: ENSP00000338258
G2E3Q7L6222, 3, ENSP000002065954MINT-68270 I2D: score=4 STRING: ENSP00000206595
COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
ULK2Q8IYT83, ENSP000003548774I2D: score=1 STRING: ENSP00000354877
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007050cell cycle arrest IDA17216128
GO:0008285negative regulation of cell proliferation IDA17216128
GO:0010507negative regulation of autophagy IMP--


WDR6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDR6
Search CenterWatch for drugs/clinical trials and news about WDR6 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WDR6 gene: 
NM_018031.3  

Unigene Cluster for WDR6:

WD repeat domain 6
Hs.654815  [show with all ESTs]
Unigene Representative Sequence: NM_018031
18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
ENST00000395474(uc011bbx.1 uc003cvj.2 uc011bby.1 uc010hkn.2 uc011bbz.1)
ENST00000429900 ENST00000488572 ENST00000462064 ENST00000489684 ENST00000473238
ENST00000438660 ENST00000415265 ENST00000452875 ENST00000420783 ENST00000471162
ENST00000472878 ENST00000448293 ENST00000419837 ENST00000461687 ENST00000489427
ENST00000491365 ENST00000498023

miRNA
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OriGene 3'-UTR Clone: WDR6
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3 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR6:
hsa-miR-873 hsa-miR-3120-3p hsa-miR-1324
SwitchGear 3'UTR luciferase reporter plasmidWDR6 3' UTR sequence
Inhib. RNA
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Additional cDNA sequence: 

AF099100.1 AK001080.1 AK022719.1 AK092079.1 AK295145.1 AK296387.1 AK297090.1 AK304117.1 
AL133589.1 AL833910.1 BC002826.2 BC078176.1 BC101707.1 BC113467.1 BC143486.1 BC143488.1 

24/45 DOTS entries (see all 45):

DT.91932300  DT.100646769  DT.95259800  DT.120852477  DT.100644682  DT.419405  DT.120852406  DT.86836253 
DT.99989441  DT.97791419  DT.97861932  DT.120852556  DT.100646764  DT.92437664  DT.120852620  DT.40107524 
DT.120852699  DT.95176872  DT.95259866  DT.97861933  DT.120852549  DT.100646770  DT.100871177  DT.120852412 

24/508 AceView cDNA sequences (see all 508):

CF455269 BU148480 AU146138 BM831849 BU902491 BQ424550 BU507952 AL833910 
BI257586 BM553503 BM706327 BX353575 AA377891 BU957103 F22136 CF134748 
BU159395 BU501203 BG761650 BG289133 BC078176 AI816982 CD513672 BM810492 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:                                                                                                                                    
SP2:                                -     -           -                                                                                 
SP3:                          -                 -     -                                                                                 
SP4:                          -     -     -     -     -                       -                                                         
SP5:                          -           -     -     -                                                                                 


ECgene alternative splicing isoforms for WDR6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGCTGTA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See WDR6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR6

SOURCE GeneReport for Unigene cluster: Hs.654815

UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5
Tissue specificity: Ubiquitous

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR6 gene from 8/20 species (see all 20)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Wdr61 , 5 WD repeat domain 61, 5 84.15(n)1
86.8(a)1
  9 (59.51 cM)5
836691  NM_031392.21  NP_113569.11 
 1085723135 
chicken
(Gallus gallus)
Aves WDR61 WD repeat domain 6 56.87(n)
49.68(a)
  416060  XM_003642012.1  XP_003642060.1 
lizard
(Anolis carolinensis)
Reptilia WDR66
--
45(a)
1 ↔ 1
2(187828359-187836661)
tropical clawed frog
(Xenopus tropicalis)
Amphibia BX774647.12   -- 71.93(n)    BX774647.1 
zebrafish
(Danio rerio)
Actinopterygii si:dkey-20d21.71 si:dkey-20d21.7 49.03(n)
39.16(a)
  100004270  NM_001113654.1  NP_001107126.1 
fruit fly
(Drosophila melanogaster)
Insecta CG331726
--
20(a)
1 ↔ 1
X(15663697-15667018)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G018606
transducin/WD40 domain-containing protein
18(a)
1 ↔ 1
4(801032-808060)
rice
(Oryza sativa)
Liliopsida --
WD domain, G-beta repeat domain containing protein...
17(a)
1 ↔ 1
3(673685-680879)


ENSEMBL Gene Tree for WDR6 (if available)
TreeFam Gene Tree for WDR6 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/205 NCBI SNPs in WDR6 are shown (see all 205    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1921010291,2
--49042842(+) CCTGTC/GAAGCC 3 -- us2k1 int10--------
rs1829151631,2
--49042845(+) GTCAAC/GCCAGT 3 -- int1 us2k10--------
rs1872661181,2
--49043022(+) ACTCAC/TAGTAA 3 -- us2k1 int10--------
rs1917830511,2
--49043051(+) AGGAGA/GGGCTA 3 -- int1 us2k10--------
rs1382466261,2
--49043459(+) GAGTGA/GGGACA 3 -- us2k1 int10--------
rs2019182141,2
--49043644(+) GCCTGG/TGGGGG 3 -- us2k1 int10--------
rs2008371511,2
--49043648(+) GGGGGA/GGGTGC 3 -- us2k1 int10--------
rs1435718751,2
--49043685(+) CCCCCA/GTCTGC 3 -- int1 us2k10--------
rs1826393991,2
--49043814(+) ATATCC/TATCCC 3 -- us2k1 int10--------
rs1882080651,2
--49043818(+) CCATCA/CCTATC 3 -- int1 us2k10--------

HapMap Linkage Disequilibrium report for WDR6 (49044495 - 49053386 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for WDR6: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR6
DNA2.0 Custom Variant and Variant Library Synthesis for WDR6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WDR6 for disorders           About GeneDecksing

OMIM gene information: 606031    OMIM disorders: --

1 disease for WDR6:    About MalaCards
peutz-jeghers syndrome

1 disease from the University of Copenhagen DISEASES database for WDR6:
Peutz-Jeghers syndrome

Export disorders for WDR6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for WDR6 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with WDR6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PubMed id 17216128)1, 2 Xie X.... Chen Y. (2007)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  4. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PubMed id 10903905)1, 2 Li D.... Roberts R. (2000)
  5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
  6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
  7. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (2012)
  8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
  9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
  10. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11180 HGNC: 12758 AceView: WDR6 Ensembl:ENSG00000178252 euGenes: HUgn11180
ECgene: WDR6 H-InvDB: WDR6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for WDR6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for WDR6 gene:
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