WDR6 Gene
protein-coding GIFtS: 47
GCID: GC03P049044
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|
WD repeat domain 6
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Aliases for WDR6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| WD Repeat Domain 61 2 | | WD Repeat-Containing Protein 62 |
Export aliases for WDR6 gene to outside databasesPrevious GC identifers: GC15U990073 GC03P048192 GC03P048899 GC03P049003 GC03P049019 |
Summaries for WDR6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for WDR6: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cellgrowth arrest. (provided by RefSeq, Aug 2008) UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acidstarvation-induced autophagy Gene Wiki entry for WDR6
|
Genomic Views for WDR6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDR6 gene promoter: SRF C/EBPbeta SRF (504 AA) Pax-6 Lmo2 Olf-1 CUTL1 AREB6 ARP-1 SEF-1 (1) Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR6 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.31 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.31WDR6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P049044: view genomic region
(about GC identifiers)
Start:
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49,044,495 bp from pter |
End:
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49,053,386 bp from pter |
Size:
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8,892 bases |
Orientation:
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plus strand |
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Proteins for WDR6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5 (See
protein sequence)Recommended Name: WD repeat-containing protein 6 Size: 1121 amino acids; 121725 Da
Subunit: Interacts with IRS4 (By similarity). Interacts with STK11/LKB1
Subcellular location: Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1
Sequence caution: Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DHK2 Q3MIT1 Q9UF63Explore the universe of human proteins at neXtProt for WDR6: NX_Q9NNW5
WDR6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060501.3 ENSEMBL proteins: ENSP00000378857 ENSP00000427893 ENSP00000387692 ENSP00000412195 ENSP00000414157 ENSP00000395993 ENSP00000413432 ENSP00000390740 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
WDR6 for ontologies About GeneDecksing
WDR6 Antibody Products: Assay Products for WDR6: |
Protein
Domains / Families for WDR6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NNW5ProtoNet protein and cluster: Q9NNW5 UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5Similarity: Belongs to the WD repeat WDR6 familySimilarity: Contains 16 WD repeats |
Function for WDR6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5Function: Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acidstarvation-induced autophagy
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR6 (NM_018031) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR6  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
WDR6 for ontologies About GeneDecksing
|
Pathways & Interactions for WDR6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for WDR6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
 5/61 Interacting proteins for WDR6 (Q9NNW51, 2, 3 ENSP000003788574) via UniProtKB, MINT, STRING, and/or I2D (see all 61)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
WDR6 for ontologies About GeneDecksing
|
Drugs & Compounds for WDR6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for WDR6 Search CenterWatch for drugs/clinical trials and news about WDR6 
|
Transcripts for WDR6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for WDR6 gene: NM_018031.3 Unigene Cluster for WDR6: WD repeat domain 6 Hs.654815 [show with all ESTs]Unigene Representative Sequence: NM_01803118/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000395474(uc011bbx.1 uc003cvj.2 uc011bby.1 uc010hkn.2 uc011bbz.1) ENST00000429900 ENST00000488572 ENST00000462064 ENST00000489684 ENST00000473238 ENST00000438660 ENST00000415265 ENST00000452875 ENST00000420783 ENST00000471162 ENST00000472878 ENST00000448293 ENST00000419837 ENST00000461687 ENST00000489427 ENST00000491365 ENST00000498023
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR6 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR6 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR6 (NM_018031) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR6  |
Additional cDNA sequence: AF099100.1 AK001080.1 AK022719.1 AK092079.1 AK295145.1 AK296387.1 AK297090.1 AK304117.1 AL133589.1 AL833910.1 BC002826.2 BC078176.1 BC101707.1 BC113467.1 BC143486.1 BC143488.1 24/45 DOTS entries (see all 45): DT.91932300 DT.100646769 DT.95259800 DT.120852477 DT.100644682 DT.419405 DT.120852406 DT.86836253 DT.99989441 DT.97791419 DT.97861932 DT.120852556 DT.100646764 DT.92437664 DT.120852620 DT.40107524 DT.120852699 DT.95176872 DT.95259866 DT.97861933 DT.120852549 DT.100646770 DT.100871177 DT.120852412 24/508 AceView cDNA sequences (see all 508): CF455269 BU148480 AU146138 BM831849 BU902491 BQ424550 BU507952 AL833910 BI257586 BM553503 BM706327 BX353575 AA377891 BU957103 F22136 CF134748 BU159395 BU501203 BG761650 BG289133 BC078176 AI816982 CD513672 BM810492 GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for WDR6
|
Expression for WDR6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CTGAGCTGTA
About this image See WDR6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDR6
SOURCE GeneReport for Unigene cluster: Hs.654815 UniProtKB/Swiss-Prot: WDR6_HUMAN, Q9NNW5Tissue specificity: Ubiquitous SABiosciences Custom PCR Arrays for WDR6
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR6 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR6 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR6 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR6 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6 |
Orthologs for WDR6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR6 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for WDR6 (if available) TreeFam Gene Tree for WDR6 (if available)  |
Paralogs for WDR6 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for WDR6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for WDR6 (49044495 - 49053386 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for WDR6: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR6 |
|
Disorders
/ Diseases for WDR6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR6 for disorders About GeneDecksing
OMIM gene information: 606031
OMIM disorders: --
1 disease for WDR6: About MalaCardspeutz-jeghers syndrome 1 disease from the University of Copenhagen DISEASES database for WDR6:Peutz-Jeghers syndrome Export disorders for WDR6 gene to outside databases
|
Publications for WDR6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR6 gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with WDR6) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PubMed id 17216128)1, 2 Xie X.... Chen Y. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PubMed id 10903905)1, 2 Li D.... Roberts R. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PubMed id 22354037)2 McKnight N.C.... Tooze S.A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
|
External Searches for WDR6 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for WDR6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR6 gene: Search GeneIP for patents involving WDR6
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for WDR6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR6 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR6 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR6 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR6 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR6 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR6 |
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 | | WDR6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR6 |
|  |  |  | | | Search ThermoFisher Antibodies for WDR6 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR6 |
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