Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR6 Gene

Aliases for WDR6 Gene

  • WD Repeat Domain 6 2 3 5

External Ids for WDR6 Gene

Previous GeneCards Identifiers for WDR6 Gene

  • GC15U990073
  • GC03P048192
  • GC03P048899
  • GC03P049003
  • GC03P049019
  • GC03P049044

Summaries for WDR6 Gene

Entrez Gene Summary for WDR6 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for WDR6 Gene

WDR6 (WD Repeat Domain 6) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and insulin receptor substrate binding.

UniProtKB/Swiss-Prot for WDR6 Gene

  • Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Wiki entry for WDR6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR6 Gene

Genomics for WDR6 Gene

Regulatory Elements for WDR6 Gene

Enhancers for WDR6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G048742 1.8 FANTOM5 Ensembl ENCODE dbSUPER 51.2 -264.7 -264694 1.1 HDGF PKNOX1 ATF1 ARNT ZFP64 TCF12 NCOA1 ZNF623 ZNF518A ZNF592 WDR6 AMT ENSG00000235236 NICN1 ENSG00000223343 QRICH1 CCDC71 TREX1 DALRD3 ARIH2
GH03G049005 1.4 ENCODE dbSUPER 62.9 +0.3 317 3.1 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 WDR6 QRICH1 IMPDH2 ENSG00000225399 NME6 GC03P049060 PIR62097
GH03G048738 1.5 Ensembl ENCODE dbSUPER 56.2 -267.4 -267354 3.0 PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF121 ZNF143 KDM4B REST WDR6 IP6K2 NCKIPSD
GH03G049237 1.7 FANTOM5 Ensembl ENCODE 44.5 +232.1 232139 2.9 PKNOX1 FOXA2 ARNT DMAP1 ZNF766 CBX5 NFYC REST ZNF592 KAT8 WDR6 AMT USP4 APEH DALRD3 ENSG00000235236 RHOA ARIH2 AMIGO3 ENSG00000270538
GH03G049016 1.4 ENCODE dbSUPER 51.7 +13.2 13199 6.8 CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZFP41 ZNF610 WDR6 AMT ENSG00000223343 QRICH1 CCDC71 P4HTM ENSG00000235236 ARIH2 QARS ARIH2OS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR6 on UCSC Golden Path with GeneCards custom track

Promoters for WDR6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152173 296 1401 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for WDR6 Gene

Chromosome:
3
Start:
49,007,062 bp from pter
End:
49,015,953 bp from pter
Size:
8,892 bases
Orientation:
Plus strand

Genomic View for WDR6 Gene

Genes around WDR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR6 Gene

Proteins for WDR6 Gene

  • Protein details for WDR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NNW5-WDR6_HUMAN
    Recommended name:
    WD repeat-containing protein 6
    Protein Accession:
    Q9NNW5
    Secondary Accessions:
    • B4DHK2
    • Q3MIT1
    • Q9UF63

    Protein attributes for WDR6 Gene

    Size:
    1121 amino acids
    Molecular mass:
    121725 Da
    Quaternary structure:
    • Interacts with IRS4 (By similarity). Interacts with STK11/LKB1.
    SequenceCaution:
    • Sequence=BAG58164.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for WDR6 Gene

Post-translational modifications for WDR6 Gene

  • Ubiquitination at Lys237, posLast=343343, posLast=418418, Lys437, isoforms=490, Lys526, Lys708, isoforms=855, isoforms=910, and Lys915
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR6 Gene

Domains & Families for WDR6 Gene

Gene Families for WDR6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NNW5

UniProtKB/Swiss-Prot:

WDR6_HUMAN :
  • Belongs to the WD repeat WDR6 family.
Family:
  • Belongs to the WD repeat WDR6 family.
genes like me logo Genes that share domains with WDR6: view

Function for WDR6 Gene

Molecular function for WDR6 Gene

UniProtKB/Swiss-Prot Function:
Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.

Gene Ontology (GO) - Molecular Function for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 17216128
GO:0043560 insulin receptor substrate binding IEA --
genes like me logo Genes that share ontologies with WDR6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR6 Gene

Localization for WDR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR6 Gene

Cytoplasm. Note=Colocalizes in the cytoplasm with STK11/LKB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR6 gene
Compartment Confidence
plasma membrane 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 17216128
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with WDR6: view

Pathways & Interactions for WDR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IDA 17216128
GO:0008285 negative regulation of cell proliferation IDA 17216128
GO:0010507 negative regulation of autophagy IMP 22354037
genes like me logo Genes that share ontologies with WDR6: view

No data available for Pathways by source and SIGNOR curated interactions for WDR6 Gene

Drugs & Compounds for WDR6 Gene

No Compound Related Data Available

Transcripts for WDR6 Gene

Unigene Clusters for WDR6 Gene

WD repeat domain 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7:
SP8: - - -

Relevant External Links for WDR6 Gene

GeneLoc Exon Structure for
WDR6
ECgene alternative splicing isoforms for
WDR6

Expression for WDR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR6 Gene

This gene is overexpressed in Plasma (33.5), Lung (6.6), Skin (6.4), and Heart (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR6 Gene



NURSA nuclear receptor signaling pathways regulating expression of WDR6 Gene:

WDR6

SOURCE GeneReport for Unigene cluster for WDR6 Gene:

Hs.654815

mRNA Expression by UniProt/SwissProt for WDR6 Gene:

Q9NNW5-WDR6_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for WDR6 Gene

  • Nervous system(5)
  • Heart(4.3)
  • Lung(3.1)
  • Intestine(2.4)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with WDR6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR6 Gene

Orthologs for WDR6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR6 34 35
  • 98.74 (n)
dog
(Canis familiaris)
Mammalia WDR6 34 35
  • 89.13 (n)
cow
(Bos Taurus)
Mammalia WDR6 34 35
  • 86.82 (n)
rat
(Rattus norvegicus)
Mammalia Wdr6 34
  • 85.34 (n)
mouse
(Mus musculus)
Mammalia Wdr6 34 16 35
  • 84.15 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR6 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR6 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR6 34 35
  • 56.62 (n)
lizard
(Anolis carolinensis)
Reptilia WDR6 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr6 34
  • 52.5 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr6 34 35
  • 48.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33172 34 35
  • 41.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004545 34
  • 41.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL056C 34
  • 42.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTT10 34 35
  • 38.67 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18899g 34
  • 37.29 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07492 34
  • 41.1 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1306.02 34
  • 38.76 (n)
Species where no ortholog for WDR6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR6 Gene

ENSEMBL:
Gene Tree for WDR6 (if available)
TreeFam:
Gene Tree for WDR6 (if available)

Paralogs for WDR6 Gene

No data available for Paralogs for WDR6 Gene

Variants for WDR6 Gene

Sequence variations from dbSNP and Humsavar for WDR6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs483352745 Uncertain significance 49,013,491(+) TCAAC(G/T)GTGGT reference, missense
rs1000378201 -- 49,009,463(+) GACCA(A/G)GGTTT intron-variant
rs1000433245 -- 49,009,949(+) TCTCA(A/G)ACTCC intron-variant
rs1000550060 -- 49,015,348(+) GAGCA(C/G)GGATG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000995727 -- 49,007,979(+) CTCAG(C/G)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR6 Gene

Variant ID Type Subtype PubMed ID
nsv954488 CNV deletion 24416366

Variation tolerance for WDR6 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR6 Gene

Human Gene Mutation Database (HGMD)
WDR6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR6 Gene

Disorders for WDR6 Gene

Relevant External Links for WDR6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR6

No disorders were found for WDR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR6 Gene

Publications for WDR6 Gene

  1. Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. (PMID: 22354037) McKnight N.C. … Tooze S.A. (EMBO J. 2012) 3 4 64
  2. Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction. (PMID: 17216128) Xie X. … Chen Y. (Mol. Cell. Biochem. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Molecular cloning, expression analysis, and chromosome mapping of WDR6, a novel human WD-repeat gene. (PMID: 10903905) Li D. … Roberts R. (Biochem. Biophys. Res. Commun. 2000) 3 4 64

Products for WDR6 Gene

Sources for WDR6 Gene

Content
Loading form....