Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR5B Gene

Aliases for WDR5B Gene

  • WD Repeat Domain 5B 2 3 5

External Ids for WDR5B Gene

Previous GeneCards Identifiers for WDR5B Gene

  • GC03M118854
  • GC03M122081
  • GC03M123412
  • GC03M123453
  • GC03M123452
  • GC03M123613
  • GC03M119504

Summaries for WDR5B Gene

Entrez Gene Summary for WDR5B Gene

  • This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5B Gene

WDR5B (WD Repeat Domain 5B) is a Protein Coding gene. An important paralog of this gene is WDR5.

UniProtKB/Swiss-Prot for WDR5B Gene

  • May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5B Gene

Genomics for WDR5B Gene

Regulatory Elements for WDR5B Gene

Enhancers for WDR5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F122414 1.1 ENCODE 23.3 -0.1 -108 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS WDR5B LOC102723582 CCDC58 FAM162A SEC22A
GH03F122513 1.1 ENCODE 22.9 -98.4 -98361 2.3 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 ZNF263 SP3 WDR5B LOC102723582 ENSG00000273454 PARP14 KPNA1 GC03P122484
GH03F122560 1 Ensembl ENCODE 22.7 -145.3 -145250 1.4 CTCF ATF1 SAP130 RAD21 RFX5 YY1 SCRT2 SMC3 GATAD2A ZNF654 WDR5B DTX3L LOC105374071
GH03F122482 0.9 ENCODE 22.7 -67.1 -67117 1.5 HDGF TBL1XR1 RFX5 GTF3C2 CBX5 SMARCC2 ETV6 FOS CREM SMARCC1 LOC102723582 WDR5B KPNA1 RPL7AP11 SEC22A CCDC58 FAM162A ENSG00000275348 GC03P122484
GH03F122381 1.1 ENCODE 18 +32.5 32517 3.5 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 WDR5B LOC102723582 FAM162A CCDC58
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR5B on UCSC Golden Path with GeneCards custom track

Promoters for WDR5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001372118 -249 2600 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3

Genomic Location for WDR5B Gene

122,411,853 bp from pter
122,416,051 bp from pter
4,199 bases
Minus strand

Genomic View for WDR5B Gene

Genes around WDR5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5B Gene

Proteins for WDR5B Gene

  • Protein details for WDR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B2RCM9
    • Q9NUL4

    Protein attributes for WDR5B Gene

    330 amino acids
    Molecular mass:
    36338 Da
    Quaternary structure:
    • Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).

neXtProt entry for WDR5B Gene

Post-translational modifications for WDR5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for WDR5B
  • Santa Cruz Biotechnology (SCBT) Antibodies for WDR5B

No data available for DME Specific Peptides for WDR5B Gene

Domains & Families for WDR5B Gene

Gene Families for WDR5B Gene

Suggested Antigen Peptide Sequences for WDR5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR5/wds family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat WDR5/wds family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR5B: view

Function for WDR5B Gene

Molecular function for WDR5B Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
genes like me logo Genes that share phenotypes with WDR5B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5B Gene

Localization for WDR5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR5B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR5B Gene

Pathways & Interactions for WDR5B Gene

SuperPathways for WDR5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR5B Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR5B Gene

Transcripts for WDR5B Gene

mRNA/cDNA for WDR5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR5B Gene

WD repeat domain 5B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5B Gene

No ASD Table

Relevant External Links for WDR5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR5B Gene

This gene is overexpressed in Tlymphocyte (55.2) and Brain (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR5B Gene

Protein tissue co-expression partners for WDR5B Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR5B Gene:


SOURCE GeneReport for Unigene cluster for WDR5B Gene:

genes like me logo Genes that share expression patterns with WDR5B: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR5B Gene

Orthologs for WDR5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR5B 34 35
  • 99.8 (n)
(Bos Taurus)
Mammalia WDR5B 34
  • 89.39 (n)
(Canis familiaris)
Mammalia WDR5B 34 35
  • 87.8 (n)
(Rattus norvegicus)
Mammalia Wdr5b 34
  • 85.16 (n)
(Mus musculus)
Mammalia Wdr5b 34 16 35
  • 84.81 (n)
(Ornithorhynchus anatinus)
Mammalia WDR5B 35
  • 84 (a)
(Monodelphis domestica)
Mammalia WDR5B 35
  • 65 (a)
(Gallus gallus)
Aves WDR5 35
  • 84 (a)
(Anolis carolinensis)
Reptilia WDR5B 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1646 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12820 34
(Danio rerio)
Actinopterygii wdr5 35
  • 83 (a)
wufk47f04 34
fruit fly
(Drosophila melanogaster)
Insecta wds 36 35
  • 84 (a)
CG10931 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea C14B1.4 36
  • 66 (a)
K04G11.4 36
  • 58 (a)
wdr-5.1 35
  • 56 (a)
ZC302.2 36
  • 52 (a)
wdr-5.2 35
  • 46 (a)
wdr-5.3 35
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02730 34
  • 56.91 (n)
(Glycine max)
eudicotyledons Gma.3842 34
(Oryza sativa)
Liliopsida Os07g0572000 34
  • 51.92 (n)
Os.25532 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 35
  • 70 (a)
Species where no ortholog for WDR5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5B Gene

Gene Tree for WDR5B (if available)
Gene Tree for WDR5B (if available)

Paralogs for WDR5B Gene

Paralogs for WDR5B Gene

(16) SIMAP similar genes for WDR5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDR5B: view

Variants for WDR5B Gene

Sequence variations from dbSNP and Humsavar for WDR5B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1067 -- 122,414,118(+) TTCTC(A/G)TAAGT utr-variant-3-prime
rs10718957 -- 122,417,368(+) GTCTC(-/A)AAAAA intron-variant, upstream-variant-2KB
rs10934592 -- 122,416,395(+) CAGGC(G/T)TAGGC intron-variant, upstream-variant-2KB
rs111928394 -- 122,413,417(+) AGCCT(C/T)GAACA utr-variant-3-prime
rs112176621 -- 122,416,826(+) TTTCC(C/T)CAGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR5B Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV deletion 18451855

Variation tolerance for WDR5B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5B Gene

Disorders for WDR5B Gene

Relevant External Links for WDR5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR5B Gene

Publications for WDR5B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3 64
  4. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 3 64
  5. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha C.M. … KAPttgen A. (Hum. Mol. Genet. 2010) 3 64

Products for WDR5B Gene

Sources for WDR5B Gene

Loading form....