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Aliases for WDR5B Gene

Aliases for WDR5B Gene

  • WD Repeat Domain 5B 2 3

External Ids for WDR5B Gene

Previous GeneCards Identifiers for WDR5B Gene

  • GC03M118854
  • GC03M122081
  • GC03M123412
  • GC03M123453
  • GC03M123452
  • GC03M123613
  • GC03M119504

Summaries for WDR5B Gene

Entrez Gene Summary for WDR5B Gene

  • This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5B Gene

WDR5B (WD Repeat Domain 5B) is a Protein Coding gene. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for WDR5B Gene

  • May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5B Gene

Genomics for WDR5B Gene

Regulatory Elements for WDR5B Gene

Genomic Location for WDR5B Gene

122,411,853 bp from pter
122,416,051 bp from pter
4,199 bases
Minus strand

Genomic View for WDR5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5B Gene

Proteins for WDR5B Gene

  • Protein details for WDR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 5B
    Protein Accession:
    Secondary Accessions:
    • B2RCM9
    • Q9NUL4

    Protein attributes for WDR5B Gene

    330 amino acids
    Molecular mass:
    36338 Da
    Quaternary structure:
    • Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).

neXtProt entry for WDR5B Gene

Proteomics data for WDR5B Gene at MOPED

Post-translational modifications for WDR5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR5B Gene

Domains & Families for WDR5B Gene

Gene Families for WDR5B Gene

Suggested Antigen Peptide Sequences for WDR5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR5/wds family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat WDR5/wds family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR5B: view

Function for WDR5B Gene

Molecular function for WDR5B Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

Gene Ontology (GO) - Molecular Function for WDR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR5B: view
genes like me logo Genes that share phenotypes with WDR5B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5B Gene

Localization for WDR5B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for WDR5B Gene

Pathways & Interactions for WDR5B Gene

SuperPathways for WDR5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR5B Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR5B Gene

Drugs & Compounds for WDR5B Gene

No Compound Related Data Available

Transcripts for WDR5B Gene

mRNA/cDNA for WDR5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR5B Gene

WD repeat domain 5B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5B Gene

No ASD Table

Relevant External Links for WDR5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR5B Gene

mRNA expression in normal human tissues for WDR5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR5B Gene

This gene is overexpressed in Tlymphocyte (55.2) and Brain (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR5B Gene

SOURCE GeneReport for Unigene cluster for WDR5B Gene Hs.567513

genes like me logo Genes that share expression patterns with WDR5B: view

Protein tissue co-expression partners for WDR5B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR5B Gene

Orthologs for WDR5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR5B 35
  • 89.39 (n)
  • 91.21 (a)
(Canis familiaris)
Mammalia WDR5B 35
  • 87.8 (n)
  • 91.46 (a)
WDR5B 36
  • 91 (a)
(Mus musculus)
Mammalia Wdr5b 35
  • 84.81 (n)
  • 83.79 (a)
Wdr5b 16
Wdr5b 36
  • 84 (a)
(Pan troglodytes)
Mammalia WDR5B 35
  • 99.8 (n)
  • 99.7 (a)
WDR5B 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr5b 35
  • 85.16 (n)
  • 85.06 (a)
(Monodelphis domestica)
Mammalia WDR5B 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia WDR5B 36
  • 84 (a)
(Gallus gallus)
Aves WDR5 36
  • 84 (a)
(Anolis carolinensis)
Reptilia WDR5B 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1646 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12820 35
(Danio rerio)
Actinopterygii wufk47f04 35
wdr5 36
  • 83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10931 37
  • 51 (a)
wds 37
  • 84 (a)
wds 36
  • 71 (a)
(Caenorhabditis elegans)
Secernentea C14B1.4 37
  • 66 (a)
K04G11.4 37
  • 58 (a)
ZC302.2 37
  • 52 (a)
wdr-5.1 36
  • 56 (a)
wdr-5.2 36
  • 46 (a)
wdr-5.3 36
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02730 35
  • 56.91 (n)
  • 59.49 (a)
(Glycine max)
eudicotyledons Gma.3842 35
(Oryza sativa)
Liliopsida Os.25532 35
Os07g0572000 35
  • 51.92 (n)
  • 53.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 36
  • 70 (a)
Species with no ortholog for WDR5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5B Gene

Gene Tree for WDR5B (if available)
Gene Tree for WDR5B (if available)

Paralogs for WDR5B Gene

(16) SIMAP similar genes for WDR5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDR5B: view

Variants for WDR5B Gene

Sequence variations from dbSNP and Humsavar for WDR5B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1067 -- 122,414,118(+) TTCTC(A/G)TAAGT utr-variant-3-prime
rs3828362 -- 122,412,930(-) ACATG(C/G)CAGAT utr-variant-3-prime
rs5852296 -- 122,411,561(+) AAACC(-/T)TTTTT downstream-variant-500B
rs9843165 -- 122,412,264(+) AGTGG(C/G)CAGAA utr-variant-3-prime
rs11553085 -- 122,411,904(+) TGTTA(C/T)TATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR5B Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV Loss 18451855

Variation tolerance for WDR5B Gene

Residual Variation Intolerance Score: 43.83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR5B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5B Gene

Disorders for WDR5B Gene

Relevant External Links for WDR5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR5B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR5B Gene

Publications for WDR5B Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 67
  2. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 67
  3. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha C.M. … KAPttgen A. (Hum. Mol. Genet. 2010) 67
  4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for WDR5B Gene

Sources for WDR5B Gene

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