WDR5B Gene
protein-coding GIFtS: 44
GCID: GC03M122081
|
|
WD repeat domain 5B
| |
Aliases
for WDR5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 5B1 2 | | FLJ112871 | | WD Repeat-Containing Protein 5B2 |
Export aliases for WDR5B gene to outside databasesPrevious GC identifers: GC03M118854 GC03M123412 GC03M123453 GC03M123452 GC03M123613 GC03M119504 |
Summaries
for WDR5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR5B:
This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-aminoacid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein maymediate protein-protein interactions. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WDR5B_HUMAN, Q86VZ2Function: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex (By similarity)
|
Genomic Views
for WDR5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR5B gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 RelA GATA-1 Nkx3-1 v2 SEF-1 (1) Nkx3-1 v3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR5B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR5B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21.1WDR5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M122081: view genomic region
(about GC identifiers)
Start:
|
122,130,700 bp from pter |
End:
|
122,134,882 bp from pter |
Size:
|
4,183 bases |
Orientation:
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minus strand |
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Proteins
for WDR5B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR5B_HUMAN, Q86VZ2 (See
protein sequence)Recommended Name: WD repeat-containing protein 5B Size: 330 amino acids; 36338 Da
Subunit: Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruitingcomponent (DCAF). Interacts with CUL4B and DDB1 (By similarity)
Secondary accessions: B2RCM9 Q9NUL4Explore the universe of human proteins at neXtProt for WDR5B: NX_Q86VZ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86VZ2
WDR5B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061942.2
ENSEMBL proteins: ENSP00000330381
Human Recombinant Protein Products:
WDR5B Antibody Products:
Assay Products for WDR5B: |
Protein
Domains /
Families
for WDR5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR5B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86VZ2ProtoNet protein and cluster: Q86VZ2 1 Blocks protein family: IPB001632 Beta G-protein (transducin) signature
UniProtKB/Swiss-Prot: WDR5B_HUMAN, Q86VZ2Similarity: Belongs to the WD repeat WDR5/wds familySimilarity: Contains 7 WD repeats |
Function
for WDR5B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WDR5B_HUMAN, Q86VZ2Function: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5B
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5B |
1 GenomeRNAi human phenotype for WDR5B:
|
Pathways & Interactions
for WDR5B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR5B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for WDR5B (Q86VZ23 ENSP000003303814) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
|
Drugs & Compounds
for WDR5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR5B
Search CenterWatch for drugs/clinical trials and news about WDR5B
|
Transcripts
for WDR5B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR5B gene: NM_019069.3 Unigene Cluster for WDR5B: WD repeat domain 5B Hs.567513 [show with all ESTs]Unigene Representative Sequence: NM_0190691 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000330689(uc003efa.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR5B (NM_019069) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR5B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5B |
Additional cDNA sequence: AK002149.1 AK315186.1 BC025762.1 BC043494.1 CR457279.1 4 DOTS entries: DT.439023 DT.91669635 DT.100779998 DT.120892719 24/80 AceView cDNA sequences (see all 80): BX097346 AU138933 BC025762 F11059 BC043494 AA135682 BQ224110 BM989318 AA135595 AI092356 CN478842 CA432764 CB157726 BQ921194 AA651788 CA313436 BU627497 CR592490 NM_019069 AI091922 D62687 AA331626 AA400131 BX390357
GeneLoc Exon Structure
|
Expression
for WDR5B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR5B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTGCAAA
About this image
See WDR5B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR5B
SOURCE GeneReport for Unigene cluster: Hs.567513
SABiosciences Custom PCR Arrays for WDR5B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR5B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR5B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5B |
Orthologs
for WDR5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR5B gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.128202 |
Xenopus laevis transcribed sequence with strong similarity more |
78.4(n) |
|
CB558728.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufk47f042 |
Danio rerio cDNA clone MGC56591 IMAGE5915175, complete more |
76.85(n) |
|
BC052124.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
wds3 |
-- |
84(a)
(best of 2) |
|
3A6 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
C14B1.43 |
guanine nucleotide binding protein |
66(a)
(best of 3) |
|
III(3777094-3778384) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G027301 |
transducin/WD40 domain-containing protein |
56.91(n)
59.49(a) |
|
828189 NM_116507.2 NP_192182.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.255322 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
70(n) |
|
AK112085.1 |
ENSEMBL Gene Tree for WDR5B (if available)
TreeFam Gene Tree for WDR5B (if available) |
Paralogs
for WDR5B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR5B gene
- POC1B2 WDR832 WDR52 ATG16L12 WDR882 SNRNP402 KATNB12 PAFAH1B12
- PRPF42 DAW12 WDR382 ATG16L22 POC1A2 WDSUB12
18 SIMAP similar genes for WDR5B using alignment to 1 protein entry: WDR5B_HUMAN:WDR5 POC1A WDR51A WDR69 DKFZp762M0115 POC1B
WDR51B FBXW7 WDR57 SNRNP40 WDR83 WDR38
SPAG16 PAFAH1B1 GNB2L1 PLRG1 SMU1 PRPF4
WDR5B for paralogs About GeneDecksing
|
Genomic Variants
for WDR5B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR5B (122130700 - 122134882 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR5B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR5B |
|
Disorders
/ Diseases
for WDR5B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR5B gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR5B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PubMed id 10369878)1, 3 Gilley J. and Fried M. (1999)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1 O'Seaghdha C.M....KAPttgen A. (2010)
- CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PubMed id 17041588)1 Higa L.A.... Zhang H. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
- Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)
|
External Searches for WDR5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR5B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR5B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR5B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR5B gene:
Search GeneIP for patents involving WDR5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR5B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR5B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR5B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR5B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR5B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR5B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR5B |
| |
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| | | | Search Tocris compounds for WDR5B |
| |  |  |  |  | | | | |
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 |
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 | | | WDR5B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5B |
|  |  |  | | | | ThermoFisher Antibodies for WDR5B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5B |
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