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Aliases for WDR5B Gene

Aliases for WDR5B Gene

  • WD Repeat Domain 5B 2 3

External Ids for WDR5B Gene

Summaries for WDR5B Gene

Entrez Gene Summary for WDR5B Gene

  • This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5B Gene

WDR5B (WD Repeat Domain 5B) is a Protein Coding gene. An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for WDR5B Gene

  • May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5B Gene

Genomics for WDR5B Gene

Genomic Location for WDR5B Gene

Start:
122,411,853 bp from pter
End:
122,416,051 bp from pter
Size:
4,199 bases
Orientation:
Minus strand

Genomic View for WDR5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5B Gene

Regulatory Elements for WDR5B Gene

Proteins for WDR5B Gene

  • Protein details for WDR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ2-WDR5B_HUMAN
    Recommended name:
    WD repeat-containing protein 5B
    Protein Accession:
    Q86VZ2
    Secondary Accessions:
    • B2RCM9
    • Q9NUL4

    Protein attributes for WDR5B Gene

    Size:
    330 amino acids
    Molecular mass:
    36338 Da
    Quaternary structure:
    • Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).

neXtProt entry for WDR5B Gene

Proteomics data for WDR5B Gene at MOPED

Post-translational modifications for WDR5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR5B Gene

Domains for WDR5B Gene

Gene Families for WDR5B Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VZ2

UniProtKB/Swiss-Prot:

WDR5B_HUMAN
Family:
  • Belongs to the WD repeat WDR5/wds family.:
    • Q86VZ2
Similarity:
  • Contains 7 WD repeats.:
    • Q86VZ2
genes like me logo Genes that share domains with WDR5B: view

Function for WDR5B Gene

Molecular function for WDR5B Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

Gene Ontology (GO) - Molecular Function for WDR5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR5B: view

Phenotypes for WDR5B Gene

GenomeRNAi human phenotypes for WDR5B:
genes like me logo Genes that share phenotypes with WDR5B: view

miRNA for WDR5B Gene

miRTarBase miRNAs that target WDR5B

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR5B Gene

Localization for WDR5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR5B Gene COMPARTMENTS Subcellular localization image for WDR5B gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR5B Gene

Pathways for WDR5B Gene

SuperPathways for WDR5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR5B Gene

None

No data available for Pathways by source for WDR5B Gene

Transcripts for WDR5B Gene

mRNA/cDNA for WDR5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR5B Gene

WD repeat domain 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5B Gene

No ASD Table

Relevant External Links for WDR5B Gene

GeneLoc Exon Structure for
WDR5B
ECgene alternative splicing isoforms for
WDR5B

Expression for WDR5B Gene

mRNA expression in normal human tissues for WDR5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for WDR5B Gene

SOURCE GeneReport for Unigene cluster for WDR5B Gene Hs.567513

genes like me logo Genes that share expressions with WDR5B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR5B Gene

Orthologs for WDR5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR5B 35
  • 99.8 (n)
  • 99.7 (a)
WDR5B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR5B 35
  • 89.39 (n)
  • 91.21 (a)
dog
(Canis familiaris)
Mammalia WDR5B 35
  • 87.8 (n)
  • 91.46 (a)
WDR5B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr5b 35
  • 84.81 (n)
  • 83.79 (a)
Wdr5b 16
Wdr5b 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR5B 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR5B 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr5b 35
  • 85.16 (n)
  • 85.06 (a)
chicken
(Gallus gallus)
Aves WDR5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR5B 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12820 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1646 35
zebrafish
(Danio rerio)
Actinopterygii wdr5 36
  • 83 (a)
OneToMany
wufk47f04 35
fruit fly
(Drosophila melanogaster)
Insecta wds 36
  • 71 (a)
OneToMany
CG10931 37
  • 51 (a)
wds 37
  • 84 (a)
worm
(Caenorhabditis elegans)
Secernentea wdr-5.1 36
  • 56 (a)
ManyToMany
wdr-5.2 36
  • 46 (a)
ManyToMany
wdr-5.3 36
  • 34 (a)
ManyToMany
ZC302.2 37
  • 52 (a)
K04G11.4 37
  • 58 (a)
C14B1.4 37
  • 66 (a)
soybean
(Glycine max)
eudicotyledons Gma.3842 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02730 35
  • 56.91 (n)
  • 59.49 (a)
rice
(Oryza sativa)
Liliopsida Os.25532 35
Os07g0572000 35
  • 51.92 (n)
  • 53.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 36
  • 70 (a)
OneToMany
Species with no ortholog for WDR5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5B Gene

ENSEMBL:
Gene Tree for WDR5B (if available)
TreeFam:
Gene Tree for WDR5B (if available)

Paralogs for WDR5B Gene

Selected SIMAP similar genes for WDR5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDR5B: view

Variants for WDR5B Gene

Sequence variations from dbSNP and Humsavar for WDR5B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1067 -- 122,414,118(+) TTCTC(A/G)TAAGT utr-variant-3-prime
rs3828362 -- 122,412,930(-) ACATG(C/G)CAGAT utr-variant-3-prime
rs5852296 -- 122,411,561(+) AAACC(-/T)TTTTT downstream-variant-500B
rs9843165 -- 122,412,264(+) AGTGG(C/G)CAGAA utr-variant-3-prime
rs11553085 -- 122,411,904(+) TGTTA(C/T)TATGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR5B Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV Loss 18451855

Relevant External Links for WDR5B Gene

HapMap Linkage Disequilibrium report
WDR5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5B Gene

Disorders for WDR5B Gene

No disorders were found for WDR5B Gene.

No data available for UniProtKB/Swiss-Prot for WDR5B Gene

Publications for WDR5B Gene

  1. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3
  5. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha C.M. … KAPttgen A. (Hum. Mol. Genet. 2010) 3

Products for WDR5B Gene

Sources for WDR5B Gene

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