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Aliases for WDR5B Gene

Aliases for WDR5B Gene

  • WD Repeat Domain 5B 2 3 5

External Ids for WDR5B Gene

Previous GeneCards Identifiers for WDR5B Gene

  • GC03M118854
  • GC03M122081
  • GC03M123412
  • GC03M123453
  • GC03M123452
  • GC03M123613
  • GC03M119504

Summaries for WDR5B Gene

Entrez Gene Summary for WDR5B Gene

  • This intronless gene encodes a protein containing several WD40 repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, including a trp-asp at the C-terminal end. The encoded protein may mediate protein-protein interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5B Gene

WDR5B (WD Repeat Domain 5B) is a Protein Coding gene. An important paralog of this gene is KATNB1.

UniProtKB/Swiss-Prot for WDR5B Gene

  • May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5B Gene

Genomics for WDR5B Gene

Regulatory Elements for WDR5B Gene

Enhancers for WDR5B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR5B on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR5B Gene

Chromosome:
3
Start:
122,411,853 bp from pter
End:
122,416,051 bp from pter
Size:
4,199 bases
Orientation:
Minus strand

Genomic View for WDR5B Gene

Genes around WDR5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5B Gene

Proteins for WDR5B Gene

  • Protein details for WDR5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ2-WDR5B_HUMAN
    Recommended name:
    WD repeat-containing protein 5B
    Protein Accession:
    Q86VZ2
    Secondary Accessions:
    • B2RCM9
    • Q9NUL4

    Protein attributes for WDR5B Gene

    Size:
    330 amino acids
    Molecular mass:
    36338 Da
    Quaternary structure:
    • Probable part of a cullin-RING E3 protein ligase complex containing CUL4B-DDB1 and a substrate-recruiting component (DCAF). Interacts with CUL4B and DDB1 (By similarity).

neXtProt entry for WDR5B Gene

Proteomics data for WDR5B Gene at MOPED

Post-translational modifications for WDR5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR5B Gene

Domains & Families for WDR5B Gene

Gene Families for WDR5B Gene

Suggested Antigen Peptide Sequences for WDR5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VZ2

UniProtKB/Swiss-Prot:

WDR5B_HUMAN :
  • Belongs to the WD repeat WDR5/wds family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat WDR5/wds family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR5B: view

Function for WDR5B Gene

Molecular function for WDR5B Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex.
genes like me logo Genes that share phenotypes with WDR5B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5B Gene

Localization for WDR5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR5B Gene COMPARTMENTS Subcellular localization image for WDR5B gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR5B Gene

Pathways & Interactions for WDR5B Gene

SuperPathways for WDR5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR5B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR5B Gene

Drugs & Compounds for WDR5B Gene

No Compound Related Data Available

Transcripts for WDR5B Gene

mRNA/cDNA for WDR5B Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR5B Gene

WD repeat domain 5B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5B Gene

No ASD Table

Relevant External Links for WDR5B Gene

GeneLoc Exon Structure for
WDR5B
ECgene alternative splicing isoforms for
WDR5B

Expression for WDR5B Gene

mRNA expression in normal human tissues for WDR5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR5B Gene

This gene is overexpressed in Tlymphocyte (55.2) and Brain (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR5B Gene



SOURCE GeneReport for Unigene cluster for WDR5B Gene Hs.567513

genes like me logo Genes that share expression patterns with WDR5B: view

Protein tissue co-expression partners for WDR5B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR5B Gene

Orthologs for WDR5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR5B 35
  • 89.39 (n)
  • 91.21 (a)
dog
(Canis familiaris)
Mammalia WDR5B 35
  • 87.8 (n)
  • 91.46 (a)
WDR5B 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr5b 35
  • 84.81 (n)
  • 83.79 (a)
Wdr5b 16
Wdr5b 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR5B 35
  • 99.8 (n)
  • 99.7 (a)
WDR5B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr5b 35
  • 85.16 (n)
  • 85.06 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR5B 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR5B 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR5B 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1646 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12820 35
zebrafish
(Danio rerio)
Actinopterygii wufk47f04 35
wdr5 36
  • 83 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10931 37
  • 51 (a)
wds 37
  • 84 (a)
wds 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C14B1.4 37
  • 66 (a)
K04G11.4 37
  • 58 (a)
ZC302.2 37
  • 52 (a)
wdr-5.1 36
  • 56 (a)
ManyToMany
wdr-5.2 36
  • 46 (a)
ManyToMany
wdr-5.3 36
  • 34 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G02730 35
  • 56.91 (n)
  • 59.49 (a)
soybean
(Glycine max)
eudicotyledons Gma.3842 35
rice
(Oryza sativa)
Liliopsida Os.25532 35
Os07g0572000 35
  • 51.92 (n)
  • 53.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 36
  • 70 (a)
OneToMany
Species with no ortholog for WDR5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5B Gene

ENSEMBL:
Gene Tree for WDR5B (if available)
TreeFam:
Gene Tree for WDR5B (if available)

Paralogs for WDR5B Gene

Paralogs for WDR5B Gene

(16) SIMAP similar genes for WDR5B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WDR5B: view

Variants for WDR5B Gene

Sequence variations from dbSNP and Humsavar for WDR5B Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1067 -- 122,414,118(+) TTCTC(A/G)TAAGT utr-variant-3-prime
rs11553085 -- 122,411,904(+) TGTTA(C/T)TATGC utr-variant-3-prime
rs9843165 -- 122,412,264(+) AGTGG(C/G)CAGAA utr-variant-3-prime
rs3828362 -- 122,412,930(-) ACATG(C/G)CAGAT utr-variant-3-prime
rs5852296 -- 122,411,561(+) AAACC(-/T)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WDR5B Gene

Variant ID Type Subtype PubMed ID
nsv3973 CNV Loss 18451855

Variation tolerance for WDR5B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR5B Gene

HapMap Linkage Disequilibrium report
WDR5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5B Gene

Disorders for WDR5B Gene

Relevant External Links for WDR5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR5B

No disorders were found for WDR5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR5B Gene

Publications for WDR5B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. (PMID: 10369878) Gilley J. … Fried M. (Hum. Mol. Genet. 1999) 2 3
  3. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PMID: 22645275) Usenovic M. … Krainc D. (Hum. Mol. Genet. 2012) 3
  4. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PMID: 20705733) O'Seaghdha C.M. … KAPttgen A. (Hum. Mol. Genet. 2010) 3
  5. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3

Products for WDR5B Gene

Sources for WDR5B Gene

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