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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR59 Gene

protein-coding   GIFtS: 48
GCID: GC16M074908

WD Repeat Domain 59

  Search for WDR59
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 591 2
WD Repeat-Containing Protein 592
KIAA19233

External Ids:    HGNC: 257061   Entrez Gene: 797262   Ensembl: ENSG000001030917   UniProtKB: Q6PJI93   

Export aliases for WDR59 gene to outside databases

Previous GC identifers: GC16M073465 GC16M060657


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR59 Gene: 
WDR59 (WD repeat domain 59) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is WDR24.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR59 gene promoter:
         AP-2gamma   Meis-1b   AREB6   c-Myb   STAT3   AP-2beta   Meis-1a   AP-2alpha   Meis-1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR59 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR59

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q22.3

WDR59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR59 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M074908:  view genomic region     (about GC identifiers)

Start:
74,907,468 bp from pter      End:
75,034,071 bp from pter
Size:
126,604 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR59_HUMAN, Q6PJI9 (See protein sequence)
Recommended Name: WD repeat-containing protein 59  
Size: 974 amino acids; 109793 Da
Subunit: Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity)
Sequence caution: Sequence=BAB67816.1; Type=Frameshift; Positions=157;
Secondary accessions: B3KRC3 Q71RE7 Q96PW5 Q9BSW6 Q9HA43
Alternative splicing: 4 isoforms:  Q6PJI9-1   Q6PJI9-2   Q6PJI9-3   Q6PJI9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR59: NX_Q6PJI9

Explore proteomics data for WDR59 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PJI9

  • WDR59 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR59 Protein Expression
    REFSEQ proteins: NP_085058.3  
    ENSEMBL proteins: 
     ENSP00000262144   ENSP00000455060   ENSP00000454382   ENSP00000457978   ENSP00000456139  
     ENSP00000457605  

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    Cloud-Clone Corp. Proteins for WDR59 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    WDR59 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q6PJI9

    ProtoNet protein and cluster: Q6PJI9

    2 Blocks protein domains:
    IPB002049 Laminin-type EGF-like domain
    IPB006575 RWD


    UniProtKB/Swiss-Prot: WDR59_HUMAN, Q6PJI9
    Similarity: Belongs to the WD repeat WDR59 family
    Similarity: Contains 1 RWD domain
    Similarity: Contains 8 WD repeats


    WDR59 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    WDR59 for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR59

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/76 Interacting proteins for WDR59 (Q6PJI93 ENSP000002621444) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHMP243863, ENSP000003503864I2D: score=1 STRING: ENSP00000350386
    RAE1P784063, ENSP000003602864I2D: score=1 STRING: ENSP00000360286
    WDR5P619643, ENSP000003514464I2D: score=1 STRING: ENSP00000351446
    SEC13P557353I2D: score=6 
    EIF1P415673I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    WDR59 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR59

    Search CenterWatch for drugs/clinical trials and news about WDR59

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR59 gene: 
    NM_030581.3  

    Unigene Cluster for WDR59:

    WD repeat domain 59
    Hs.280951  [show with all ESTs]
    Unigene Representative Sequence: NM_030581
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000262144(uc002fdf.1 uc002fdg.1 uc002fdh.1 uc002fdi.3)
    ENST00000569183 ENST00000569968 ENST00000563797 ENST00000567018 ENST00000569788
    ENST00000563381 ENST00000569229 ENST00000566924 ENST00000570070 ENST00000569115
    ENST00000562371 ENST00000569549 ENST00000536050(uc021tli.1) ENST00000562539
    ENST00000562854 ENST00000561717 ENST00000568462
    miRNA
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    hsa-miR-1207-3p hsa-miR-590-3p hsa-miR-500a hsa-miR-764 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidWDR59 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR59

    Additional mRNA sequence: 

    AB067510.1 AK022332.1 AK091316.1 AK302557.1 AL832078.1 BC004519.2 BC014887.2 

    14 DOTS entries:

    DT.455790  DT.95277910  DT.97806705  DT.75105958  DT.97780556  DT.100036192  DT.100774678  DT.65284579 
    DT.100017641  DT.40208856  DT.92424000  DT.95277907  DT.308089  DT.97786620 

    24/261 AceView cDNA sequences (see all 261):

    AI184889 BC004519 AA721081 BM792889 AW848503 BQ184153 AI249174 AA702238 
    BF343138 T33711 F02932 AA767682 AI634536 BQ777415 AI802968 BM475891 
    CR600875 BU634256 Z41704 AA635948 CD632654 BF508517 BQ071572 AW028282 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for WDR59 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
    SP1:                                                                                                  -           -           -           -                 -   
    SP2:              -           -                                                                       -           -           -           -                     
    SP3:                                                                                                                                                            
    SP4:              -                                                                                                                                             
    SP5:                          -                                                                                                                                 

    ExUns: 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
    SP1:  -     -           -                             -                                       
    SP2:                                                                                          
    SP3:                    -                             -                                       
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for WDR59

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTTTAGAAG
    WDR59 Expression
    About this image


    See WDR59 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR59

    SOURCE GeneReport for Unigene cluster: Hs.280951
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WDR59 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr591 , 5 WD repeat domain 591, 5 88.36(n)1
    96.3(a)1
      8 (57.98 cM)5
    3194811  NM_001170743.11  NP_001164214.11 
     1114487845 
    chicken
    (Gallus gallus)
    Aves WDR591 WD repeat domain 59 80.4(n)
    89(a)
      415688  NM_001012776.1  NP_001012794.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR596
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343840.1(56515-93741)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.50672 Xenopus laevis transcribed sequence with weak similarity more 78.09(n)    BX846183.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr596
    WD repeat domain 59
    71(a)
    1 ↔ 1
    18(4510776-4609878)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47051 CG4705 46.87(n)
    38.03(a)
      34540  NM_205960.3  NP_995682.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MTC5(YDR128W)4
    MTC51
    Subunit of the SEA (Seh1-associated) complex, a coatomer-related more4
    Mtc5p1
    42.1(n)1
    28.99(a)1
      4(709549-712995)4
    8517061, 4  NP_010413.31  NP_010413.14 


    ENSEMBL Gene Tree for WDR59 (if available)
    TreeFam Gene Tree for WDR59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR59 gene
    WDR242  

    WDR59 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WDR59
    PGOHUM00000262347 PGOHUM00000243093


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3133 SNPs in WDR59 are shown (see all 3133)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs339885911,2
    C--60712540(+) TTTTT-/TGAGAC 1 -- int11Minor allele frequency- T:0.00NA 2
    rs1912932891,2
    --74906999(+) GATGGG/TGTTTC 1 -- ds50010--------
    rs1405983521,2
    C--74907104(+) TGCCCA/GGCCTA 1 -- ds50010--------
    rs776933601,2
    C,F--74907180(+) CTCAGG/TTGATC 1 -- ds50014Minor allele frequency- T:0.10NA CSA WA 242
    rs129283211,2
    C,A--74907234(+) CATGGG/TGCCTG 1 -- ds50015Minor allele frequency- T:0.32NA WA EA 362
    rs169487661,2
    C,F,H--74907324(+) GAAGAA/GCCTTA 1 -- ds500125Minor allele frequency- G:0.09NA NS EA WA 2626
    rs133388941,2
    C,F,A,H--74907342(+) AATTCC/TATTTT 1 -- ds500116Minor allele frequency- T:0.11NS EA NA WA 1930
    rs9337241,2
    C,F,O,A,H--74907391(-) CTCCGA/GTTTTT 1 -- ds500127Minor allele frequency- G:0.49NS EA NA WA CSA 2574
    rs1445627281,2
    C--74907425(+) ATAGCC/TACCTT 1 -- ds50010--------
    rs99321761,2
    C,F,A,H--74907440(+) TAGAAT/GTAGGG 1 -- ds500117Minor allele frequency- G:0.09NS EA NA WA 2222

    HapMap Linkage Disequilibrium report for WDR59 (74907468 - 75034071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for WDR59:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666064CNV Deletion23128226
    nsv833280CNV Loss17160897
    nsv526213CNV Loss19592680
    nsv510420CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDR59 for disorders           About MalaCards

    WDR59 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR59
    Human Genome Epidemiology (HuGE) Navigator: WDR59 (2 documents)

    Export disorders for WDR59 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR59 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with WDR59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T....Ohara O. (2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (2010)
    4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79726 HGNC: 25706 AceView: FLJ12270 Ensembl:ENSG00000103091 euGenes: HUgn79726
    ECgene: WDR59 H-InvDB: WDR59

    (According to HUGE)
    About This Section
    HUGE: KIAA1923

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR59 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR59 gene:
    Search GeneIP for patents involving WDR59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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