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Aliases for WDR59 Gene

Aliases for WDR59 Gene

  • WD Repeat Domain 59 2 3 5
  • KIAA1923 4
  • FP977 3

External Ids for WDR59 Gene

Previous GeneCards Identifiers for WDR59 Gene

  • GC16M073465
  • GC16M060657

Summaries for WDR59 Gene

GeneCards Summary for WDR59 Gene

WDR59 (WD Repeat Domain 59) is a Protein Coding gene. An important paralog of this gene is WDR24.

UniProtKB/Swiss-Prot for WDR59 Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR59 Gene

Genomics for WDR59 Gene

Regulatory Elements for WDR59 Gene

Enhancers for WDR59 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR59 on UCSC Golden Path with GeneCards custom track

Promoters for WDR59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR59 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR59 Gene

74,871,367 bp from pter
75,000,173 bp from pter
128,807 bases
Minus strand

Genomic View for WDR59 Gene

Genes around WDR59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR59 Gene

Proteins for WDR59 Gene

  • Protein details for WDR59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 59
    Protein Accession:
    Secondary Accessions:
    • B3KRC3
    • Q71RE7
    • Q96PW5
    • Q9BSW6
    • Q9HA43

    Protein attributes for WDR59 Gene

    974 amino acids
    Molecular mass:
    109793 Da
    Quaternary structure:
    • Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.
    • Sequence=BAB67816.1; Type=Frameshift; Positions=157; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR59 Gene


neXtProt entry for WDR59 Gene

Proteomics data for WDR59 Gene at MOPED

Post-translational modifications for WDR59 Gene

  • Ubiquitination at Lys 588 and Lys 864
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR59 Gene

Domains & Families for WDR59 Gene

Gene Families for WDR59 Gene

Suggested Antigen Peptide Sequences for WDR59 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RWD domain.
  • Belongs to the WD repeat WDR59 family.
  • Contains 8 WD repeats.
  • Contains 1 RWD domain.
  • Belongs to the WD repeat WDR59 family.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with WDR59: view

Function for WDR59 Gene

Molecular function for WDR59 Gene

UniProtKB/Swiss-Prot Function:
As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
genes like me logo Genes that share phenotypes with WDR59: view

Animal Models for WDR59 Gene

MGI Knock Outs for WDR59:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR59 Gene

Localization for WDR59 Gene

Subcellular locations from

Jensen Localization Image for WDR59 Gene COMPARTMENTS Subcellular localization image for WDR59 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for WDR59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with WDR59: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR59 Gene

Pathways & Interactions for WDR59 Gene

SuperPathways for WDR59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR59 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR59 Gene

Drugs & Compounds for WDR59 Gene

No Compound Related Data Available

Transcripts for WDR59 Gene

Unigene Clusters for WDR59 Gene

WD repeat domain 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR59 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - -
SP2: - - - - - -
SP4: -
SP5: -
SP6: - -
SP7: -
SP10: -
SP11: -

ExUns: 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1: - - - -
SP3: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for WDR59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR59 Gene

mRNA expression in normal human tissues for WDR59 Gene

Protein differential expression in normal tissues from HIPED for WDR59 Gene

This gene is overexpressed in Frontal cortex (22.9), Spinal cord (13.7), and Bone marrow mesenchymal stem cell (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR59 Gene

SOURCE GeneReport for Unigene cluster for WDR59 Gene Hs.280951

genes like me logo Genes that share expression patterns with WDR59: view

Protein tissue co-expression partners for WDR59 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR59 Gene

Orthologs for WDR59 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR59 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR59 35
  • 89.49 (n)
  • 97.33 (a)
WDR59 36
  • 97 (a)
(Canis familiaris)
Mammalia WDR59 35
  • 90.14 (n)
  • 97.22 (a)
WDR59 36
  • 97 (a)
(Mus musculus)
Mammalia Wdr59 35
  • 88.36 (n)
  • 96.3 (a)
Wdr59 16
Wdr59 36
  • 94 (a)
(Pan troglodytes)
Mammalia WDR59 35
  • 99.21 (n)
  • 99.49 (a)
WDR59 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr59 35
  • 88.78 (n)
  • 96.43 (a)
(Monodelphis domestica)
Mammalia WDR59 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia WDR59 36
  • 92 (a)
(Gallus gallus)
Aves WDR59 35
  • 80.4 (n)
  • 89 (a)
WDR59 36
  • 89 (a)
(Anolis carolinensis)
Reptilia WDR59 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr59 35
  • 73.23 (n)
  • 81.78 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5067 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12997 35
(Danio rerio)
Actinopterygii wdr59 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008331 35
  • 48.53 (n)
  • 40.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4705 35
  • 47.03 (n)
  • 38.07 (a)
CG4705 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR067W 35
  • 41.45 (n)
  • 30.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19734g 35
  • 42.17 (n)
  • 29.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 35
  • 42.52 (n)
  • 31.2 (a)
MTC5 36
  • 20 (a)
MTC5 38
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC11E3.05 35
  • 42.29 (n)
  • 29.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for WDR59:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR59 Gene

Gene Tree for WDR59 (if available)
Gene Tree for WDR59 (if available)

Paralogs for WDR59 Gene

Paralogs for WDR59 Gene Pseudogenes for WDR59 Gene

genes like me logo Genes that share paralogs with WDR59: view

Variants for WDR59 Gene

Sequence variations from dbSNP and Humsavar for WDR59 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11557260 - 74,938,200(-) GGCAC(A/C)CAGAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs3921019 -- 74,959,867(-) GAAtt(C/T)cttct intron-variant
rs3636 -- 74,903,825(+) ACAAA(A/C/G)TGATT intron-variant
rs6927 -- 74,873,709(+) GTGTC(A/G)TATTT utr-variant-3-prime
rs3937016 -- 74,947,095(+) TCCAA(C/T)TAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR59 Gene

Variant ID Type Subtype PubMed ID
nsv833280 CNV Loss 17160897
nsv526213 CNV Loss 19592680
nsv510420 CNV Loss 20534489
esv2666064 CNV Deletion 23128226

Variation tolerance for WDR59 Gene

Residual Variation Intolerance Score: 6.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.24; 62.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR59 Gene

Disorders for WDR59 Gene

Relevant External Links for WDR59

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR59 Gene

Publications for WDR59 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WDR59 Gene

Sources for WDR59 Gene