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Aliases for WDR59 Gene

Aliases for WDR59 Gene

  • WD Repeat Domain 59 2 3
  • WD Repeat-Containing Protein 59 3
  • KIAA1923 4
  • FP977 3

External Ids for WDR59 Gene

Previous GeneCards Identifiers for WDR59 Gene

  • GC16M073465
  • GC16M060657

Summaries for WDR59 Gene

GeneCards Summary for WDR59 Gene

WDR59 (WD Repeat Domain 59) is a Protein Coding gene. An important paralog of this gene is WDR24.

UniProtKB/Swiss-Prot for WDR59 Gene

  • As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR59 Gene

Genomics for WDR59 Gene

Regulatory Elements for WDR59 Gene

Genomic Location for WDR59 Gene

74,871,367 bp from pter
75,000,173 bp from pter
128,807 bases
Minus strand

Genomic View for WDR59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR59 Gene

Proteins for WDR59 Gene

  • Protein details for WDR59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 59
    Protein Accession:
    Secondary Accessions:
    • B3KRC3
    • Q71RE7
    • Q96PW5
    • Q9BSW6
    • Q9HA43

    Protein attributes for WDR59 Gene

    974 amino acids
    Molecular mass:
    109793 Da
    Quaternary structure:
    • Interacts with DDB1-CUL4A/B E3 ligase complexes (By similarity). Within the GATOR complex, component of the GATOR2 subcomplex, made of MIOS, SEC13, SEH1L, WDR24 and WDR59. The GATOR complex strongly interacts with RRAGA/RRAGC and RRAGB/RRAGC heterodimers.
    • Sequence=BAB67816.1; Type=Frameshift; Positions=157; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR59 Gene


neXtProt entry for WDR59 Gene

Proteomics data for WDR59 Gene at MOPED

Post-translational modifications for WDR59 Gene

  • Ubiquitination at Lys588 and Lys864
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WDR59 Gene

Domains for WDR59 Gene

Gene Families for WDR59 Gene

  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for WDR59 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6PJI9
  • Contains 1 RWD domain.
  • Belongs to the WD repeat WDR59 family.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with WDR59: view

Function for WDR59 Gene

Molecular function for WDR59 Gene

UniProtKB/Swiss-Prot Function: As a component of the GATOR2 complex, inhibits GATOR1 complex, an inhibitor of the amino acid-sensing branch of the TORC1 pathway

Gene Ontology (GO) - Molecular Function for WDR59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR59: view

miRNA for WDR59 Gene

miRTarBase miRNAs that target WDR59

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR59 Gene

Localization for WDR59 Gene

Subcellular locations from

Jensen Localization Image for WDR59 Gene COMPARTMENTS Subcellular localization image for WDR59 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for WDR59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with WDR59: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR59 Gene

Pathways for WDR59 Gene

SuperPathways for WDR59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with WDR59: view

No data available for Pathways by source for WDR59 Gene

Transcripts for WDR59 Gene

Unigene Clusters for WDR59 Gene

WD repeat domain 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR59 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^
SP1: - - - - -
SP2: - - - - - -
SP4: -
SP5: -
SP6: - -
SP7: -
SP10: -
SP11: -

ExUns: 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28
SP1: - - - -
SP3: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for WDR59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR59 Gene

mRNA expression in normal human tissues for WDR59 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR59 Gene

SOURCE GeneReport for Unigene cluster for WDR59 Gene Hs.280951

genes like me logo Genes that share expressions with WDR59: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR59 Gene

Orthologs for WDR59 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR59 35
  • 99.21 (n)
  • 99.49 (a)
WDR59 36
  • 100 (a)
(Bos Taurus)
Mammalia WDR59 35
  • 89.49 (n)
  • 97.33 (a)
WDR59 36
  • 97 (a)
(Canis familiaris)
Mammalia WDR59 35
  • 90.14 (n)
  • 97.22 (a)
WDR59 36
  • 97 (a)
(Mus musculus)
Mammalia Wdr59 35
  • 88.36 (n)
  • 96.3 (a)
Wdr59 16
Wdr59 36
  • 94 (a)
(Monodelphis domestica)
Mammalia WDR59 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia WDR59 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Wdr59 35
  • 88.78 (n)
  • 96.43 (a)
(Gallus gallus)
Aves WDR59 35
  • 80.4 (n)
  • 89 (a)
WDR59 36
  • 89 (a)
(Anolis carolinensis)
Reptilia WDR59 36
  • 85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5067 35
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr59 35
  • 73.23 (n)
  • 81.78 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12997 35
(Danio rerio)
Actinopterygii wdr59 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008331 35
  • 48.53 (n)
  • 40.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4705 35
  • 47.03 (n)
  • 38.07 (a)
CG4705 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR067W 35
  • 41.45 (n)
  • 30.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MTC5 35
  • 42.52 (n)
  • 31.2 (a)
MTC5 36
  • 20 (a)
MTC5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19734g 35
  • 42.17 (n)
  • 29.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC11E3.05 35
  • 42.29 (n)
  • 29.78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for WDR59:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR59 Gene

Gene Tree for WDR59 (if available)
Gene Tree for WDR59 (if available)

Paralogs for WDR59 Gene

Paralogs for WDR59 Gene Pseudogenes for WDR59 Gene

genes like me logo Genes that share paralogs with WDR59: view

Variants for WDR59 Gene

Sequence variations from dbSNP and Humsavar for WDR59 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3636 -- 74,903,825(+) ACAAA(A/C/G)TGATT intron-variant
rs6927 -- 74,873,709(+) GTGTC(A/G)TATTT utr-variant-3-prime
rs14308 -- 74,886,293(+) TGGTC(A/G)CGTTC reference, synonymous-codon
rs713257 -- 74,911,496(-) ATACC(C/G)GTTCA intron-variant
rs933724 -- 74,873,493(-) CTCCG(A/G)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for WDR59 Gene

Variant ID Type Subtype PubMed ID
nsv833280 CNV Loss 17160897
nsv526213 CNV Loss 19592680
nsv510420 CNV Loss 20534489
esv2666064 CNV Deletion 23128226

Relevant External Links for WDR59 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR59 Gene

Disorders for WDR59 Gene

Relevant External Links for WDR59

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WDR59: view

No data available for UniProtKB/Swiss-Prot for WDR59 Gene

Publications for WDR59 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48

Products for WDR59 Gene

  • Addgene plasmids for WDR59

Sources for WDR59 Gene

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