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Aliases for WDR55 Gene

Aliases for WDR55 Gene

  • WD Repeat Domain 55 2 3 5

External Ids for WDR55 Gene

Previous GeneCards Identifiers for WDR55 Gene

  • GC05P140026
  • GC05P140044
  • GC05P135189
  • GC05P141418
  • GC05P141562
  • GC05P141664
  • GC05P141765

Summaries for WDR55 Gene

GeneCards Summary for WDR55 Gene

WDR55 (WD Repeat Domain 55) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR55 Gene

  • Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR55 Gene

Genomics for WDR55 Gene

Regulatory Elements for WDR55 Gene

Enhancers for WDR55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F140710 1.2 ENCODE 11.1 +46.3 46308 1.9 PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 ZNF143 PCDHA4 HDAC3 LOC102723915 HARS SRA1 TMCO6 PCDHA1 LOC101929719 WDR55 PCDHA2
GH05F140699 1.1 ENCODE 11.6 +36.0 36011 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF2 ETS1 YY1 SLC30A9 ZNF143 SRA1 WDR55 DND1 EIF4EBP3 ZMAT2 GC05P141885 VTRNA1-1
GH05F140575 1.1 Ensembl ENCODE 11.1 -89.2 -89213 0.4 ELF3 HDGF CTCF SAP130 ARID4B CEBPG ZNF48 RAD21 GATAD1 SMC3 EIF4EBP3 WDR55 DND1 IK MIR3655 NDUFA2 GC05P141897 APBB3 MIR6831
GH05F140563 1.1 ENCODE 11 -99.8 -99750 3.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF207 CD14 PCDHGB1 HARS PCDHGA9 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 PCDHA5
GH05F140568 0.9 Ensembl ENCODE 11.1 -95.3 -95321 2.6 PKNOX1 HLF CBFB MNT EBF1 RELA ZKSCAN1 GLIS1 SCRT2 IKZF1 CD14 SRA1 TMCO6 EIF4EBP3 WDR55 DND1 ENSG00000200051 ANKHD1 ANKHD1-EIF4EBP3 IK
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR55 on UCSC Golden Path with GeneCards custom track

Promoters for WDR55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001414513 424 2601 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for WDR55 Gene

Chromosome:
5
Start:
140,664,676 bp from pter
End:
140,674,124 bp from pter
Size:
9,449 bases
Orientation:
Plus strand

Genomic View for WDR55 Gene

Genes around WDR55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR55 Gene

Proteins for WDR55 Gene

  • Protein details for WDR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y2-WDR55_HUMAN
    Recommended name:
    WD repeat-containing protein 55
    Protein Accession:
    Q9H6Y2
    Secondary Accessions:
    • Q9NXK4

    Protein attributes for WDR55 Gene

    Size:
    383 amino acids
    Molecular mass:
    42070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR55 Gene

Post-translational modifications for WDR55 Gene

  • Ubiquitination at Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR55 Gene

No data available for DME Specific Peptides for WDR55 Gene

Domains & Families for WDR55 Gene

Gene Families for WDR55 Gene

Suggested Antigen Peptide Sequences for WDR55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6Y2

UniProtKB/Swiss-Prot:

WDR55_HUMAN :
  • Belongs to the WD repeat WDR55 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat WDR55 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR55: view

Function for WDR55 Gene

Molecular function for WDR55 Gene

UniProtKB/Swiss-Prot Function:
Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with WDR55: view

Phenotypes for WDR55 Gene

MGI mutant phenotypes for WDR55:
inferred from 1 alleles
GenomeRNAi human phenotypes for WDR55:
genes like me logo Genes that share phenotypes with WDR55: view

Animal Models for WDR55 Gene

MGI Knock Outs for WDR55:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR55 Gene

Localization for WDR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR55 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR55 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR55: view

Pathways & Interactions for WDR55 Gene

SuperPathways for WDR55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing ISS --
GO:0008150 biological_process ND --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR55: view

No data available for Pathways by source and SIGNOR curated interactions for WDR55 Gene

Transcripts for WDR55 Gene

Unigene Clusters for WDR55 Gene

WD repeat domain 55:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR55 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2:
SP3:
SP4:

Relevant External Links for WDR55 Gene

GeneLoc Exon Structure for
WDR55
ECgene alternative splicing isoforms for
WDR55

Expression for WDR55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR55 Gene

Protein differential expression in normal tissues from HIPED for WDR55 Gene

This gene is overexpressed in Pancreas (33.3), Lung (14.4), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR55 Gene



Protein tissue co-expression partners for WDR55 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR55 Gene:

WDR55

SOURCE GeneReport for Unigene cluster for WDR55 Gene:

Hs.286261
genes like me logo Genes that share expression patterns with WDR55: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR55 Gene

Orthologs for WDR55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR55 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia WDR55 34 35
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia WDR55 34 35
  • 89.49 (n)
rat
(Rattus norvegicus)
Mammalia Wdr55 34
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Wdr55 34 16 35
  • 83.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR55 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR55 35
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR55 34
  • 69.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490380 34
  • 64.52 (n)
Str.15755 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15646 34
zebrafish
(Danio rerio)
Actinopterygii wdr55 34 35
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008286 34
  • 47.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14722 34 35
  • 46.76 (n)
worm
(Caenorhabditis elegans)
Secernentea Y44F5A.1 35
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34260 34
  • 47.95 (n)
rice
(Oryza sativa)
Liliopsida Os07g0660700 34
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToOne
Species where no ortholog for WDR55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR55 Gene

ENSEMBL:
Gene Tree for WDR55 (if available)
TreeFam:
Gene Tree for WDR55 (if available)

Paralogs for WDR55 Gene

Pseudogenes.org Pseudogenes for WDR55 Gene

genes like me logo Genes that share paralogs with WDR55: view

No data available for Paralogs for WDR55 Gene

Variants for WDR55 Gene

Sequence variations from dbSNP and Humsavar for WDR55 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1050222 -- 140,673,985(-) CCCAT(C/T)TGCAG upstream-variant-2KB, utr-variant-3-prime
rs1052760 -- 140,671,051(-) CCAGT(G/T)ATCTT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1052762 -- 140,671,037(-) TGGCC(A/G)TTCCT intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1052767 -- 140,670,951(+) ACAAA(C/G)AGGAC intron-variant, utr-variant-3-prime
rs1065342 -- 140,673,947(-) TCCCC(A/C)CCACC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR55 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV gain 19718026
nsv964945 CNV duplication 23825009

Variation tolerance for WDR55 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR55 Gene

Disorders for WDR55 Gene

Relevant External Links for WDR55

Genetic Association Database (GAD)
WDR55
Human Genome Epidemiology (HuGE) Navigator
WDR55
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR55

No disorders were found for WDR55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR55 Gene

Publications for WDR55 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 46 64
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64

Products for WDR55 Gene

Sources for WDR55 Gene

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