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Aliases for WDR55 Gene

Aliases for WDR55 Gene

  • WD Repeat Domain 55 2 3 5

External Ids for WDR55 Gene

Previous GeneCards Identifiers for WDR55 Gene

  • GC05P140026
  • GC05P140044
  • GC05P135189
  • GC05P141418
  • GC05P141562
  • GC05P141664
  • GC05P141765
  • GC05P141865
  • GC05P141974
  • GC05P142074

Summaries for WDR55 Gene

GeneCards Summary for WDR55 Gene

WDR55 (WD Repeat Domain 55) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR55 Gene

  • Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

Additional gene information for WDR55 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR55 Gene

Genomics for WDR55 Gene

GeneHancer (GH) Regulatory Elements for WDR55 Gene

Promoters and enhancers for WDR55 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140663 Promoter/Enhancer 1.6 Ensembl ENCODE 550.8 +0.1 101 2.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B WDR55 SRA1 TMCO6 CD14 PCDHA9 PIR42041 GC05P142218
GH05I141319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.3 +656.0 655974 1.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF213 TAF7 PCDHB15 ANKHD1 ENSG00000272108 WDR55 PCDHB9 LOC102723915 FCHSD1 PCDHB18P PCDHB6
GH05I140637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.1 -25.7 -25670 2.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TMCO6 HARS2 ANKHD1 WDR55 HDAC3 LOC102723915 SRA1 PURA MALINC1 CD14
GH05I140646 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 25.8 -17.1 -17057 2.4 HDGF FOXA2 PKNOX1 SMAD1 ARNT SIN3A DMAP1 ZNF2 YY1 POLR2B IK NDUFA2 MIR3655 ANKHD1 LOC102723915 HDAC3 WDR55 HARS2 SRA1 TMCO6
GH05I140112 Promoter/Enhancer 2.4 UCNEbase EPDnew Ensembl ENCODE 19.2 -550.6 -550577 3.9 HDGF SMAD1 ARID4B SIN3A ZNF2 CBX5 ZNF416 ZNF207 SP5 ZHX2 PIR63019 PURA HARS2 ANKHD1 WDR55 TMCO6 IK GC05P140117
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR55 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR55 gene promoter:

Genomic Locations for WDR55 Gene

Genomic Locations for WDR55 Gene
chr5:140,664,676-140,674,124
(GRCh38/hg38)
Size:
9,449 bases
Orientation:
Plus strand
chr5:140,044,261-140,053,709
(GRCh37/hg19)

Genomic View for WDR55 Gene

Genes around WDR55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR55 Gene

Proteins for WDR55 Gene

  • Protein details for WDR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y2-WDR55_HUMAN
    Recommended name:
    WD repeat-containing protein 55
    Protein Accession:
    Q9H6Y2
    Secondary Accessions:
    • Q9NXK4

    Protein attributes for WDR55 Gene

    Size:
    383 amino acids
    Molecular mass:
    42070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR55 Gene

Post-translational modifications for WDR55 Gene

Other Protein References for WDR55 Gene

No data available for DME Specific Peptides for WDR55 Gene

Domains & Families for WDR55 Gene

Gene Families for WDR55 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6Y2

UniProtKB/Swiss-Prot:

WDR55_HUMAN :
  • Belongs to the WD repeat WDR55 family.
Family:
  • Belongs to the WD repeat WDR55 family.
genes like me logo Genes that share domains with WDR55: view

Function for WDR55 Gene

Molecular function for WDR55 Gene

UniProtKB/Swiss-Prot Function:
Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

Phenotypes From GWAS Catalog for WDR55 Gene

Gene Ontology (GO) - Molecular Function for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with WDR55: view

Phenotypes for WDR55 Gene

MGI mutant phenotypes for WDR55:
inferred from 1 alleles
GenomeRNAi human phenotypes for WDR55:
genes like me logo Genes that share phenotypes with WDR55: view

Animal Models for WDR55 Gene

MGI Knock Outs for WDR55:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR55 Gene

Localization for WDR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR55 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR55 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR55: view

Pathways & Interactions for WDR55 Gene

SuperPathways for WDR55 Gene

No Data Available

Interacting Proteins for WDR55 Gene

Gene Ontology (GO) - Biological Process for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing ISS,IBA --
GO:0008150 biological_process ND --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR55: view

No data available for Pathways by source and SIGNOR curated interactions for WDR55 Gene

Drugs & Compounds for WDR55 Gene

No Compound Related Data Available

Transcripts for WDR55 Gene

Unigene Clusters for WDR55 Gene

WD repeat domain 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR55 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2:
SP3:
SP4:

Relevant External Links for WDR55 Gene

GeneLoc Exon Structure for
WDR55
ECgene alternative splicing isoforms for
WDR55

Expression for WDR55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR55 Gene

Protein differential expression in normal tissues from HIPED for WDR55 Gene

This gene is overexpressed in Pancreas (33.3), Lung (14.4), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR55 Gene



Protein tissue co-expression partners for WDR55 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR55 Gene:

WDR55

SOURCE GeneReport for Unigene cluster for WDR55 Gene:

Hs.286261

Evidence on tissue expression from TISSUES for WDR55 Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with WDR55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR55 Gene

Orthologs for WDR55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR55 33 34
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia WDR55 33 34
  • 89.61 (n)
dog
(Canis familiaris)
Mammalia WDR55 33 34
  • 89.49 (n)
rat
(Rattus norvegicus)
Mammalia Wdr55 33
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Wdr55 33 16 34
  • 83.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR55 34
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR55 34
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR55 33
  • 69.8 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490380 33
  • 64.52 (n)
Str.15755 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15646 33
zebrafish
(Danio rerio)
Actinopterygii wdr55 33 34
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008286 33
  • 47.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14722 33 34
  • 46.76 (n)
worm
(Caenorhabditis elegans)
Secernentea Y44F5A.1 34
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34260 33
  • 47.95 (n)
rice
(Oryza sativa)
Liliopsida Os07g0660700 33
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
OneToOne
Species where no ortholog for WDR55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR55 Gene

ENSEMBL:
Gene Tree for WDR55 (if available)
TreeFam:
Gene Tree for WDR55 (if available)

Paralogs for WDR55 Gene

Pseudogenes.org Pseudogenes for WDR55 Gene

genes like me logo Genes that share paralogs with WDR55: view

No data available for Paralogs for WDR55 Gene

Variants for WDR55 Gene

Sequence variations from dbSNP and Humsavar for WDR55 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs145532449 uncertain-significance, Retinitis pigmentosa-deafness syndrome 140,673,945(+) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs77576083 uncertain-significance, Retinitis pigmentosa-deafness syndrome 140,673,976(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs917868012 uncertain-significance, Retinitis pigmentosa-deafness syndrome 140,673,926(+) T/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000090517 -- 140,668,415(+) A/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000253074 -- 140,674,508(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR55 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV gain 19718026
nsv964945 CNV duplication 23825009

Variation tolerance for WDR55 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR55 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR55 Gene

Disorders for WDR55 Gene

Additional Disease Information for WDR55

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WDR55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR55 Gene

Publications for WDR55 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  2. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D … Psaty BM (Arteriosclerosis, thrombosis, and vascular biology 2008) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for WDR55 Gene

Sources for WDR55 Gene

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