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Aliases for WDR55 Gene

Aliases for WDR55 Gene

  • WD Repeat Domain 55 2 3 5

External Ids for WDR55 Gene

Previous GeneCards Identifiers for WDR55 Gene

  • GC05P140026
  • GC05P140044
  • GC05P135189
  • GC05P141418
  • GC05P141562

Summaries for WDR55 Gene

GeneCards Summary for WDR55 Gene

WDR55 (WD Repeat Domain 55) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR55 Gene

  • Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR55 Gene

Genomics for WDR55 Gene

Regulatory Elements for WDR55 Gene

Enhancers for WDR55 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR55 on UCSC Golden Path with GeneCards custom track

Promoters for WDR55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR55 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR55 Gene

140,664,676 bp from pter
140,674,124 bp from pter
9,449 bases
Plus strand

Genomic View for WDR55 Gene

Genes around WDR55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR55 Gene

Proteins for WDR55 Gene

  • Protein details for WDR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 55
    Protein Accession:
    Secondary Accessions:
    • Q9NXK4

    Protein attributes for WDR55 Gene

    383 amino acids
    Molecular mass:
    42070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR55 Gene


neXtProt entry for WDR55 Gene

Proteomics data for WDR55 Gene at MOPED

Post-translational modifications for WDR55 Gene

  • Ubiquitination at Lys 320
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR55 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR55 Gene

Domains & Families for WDR55 Gene

Gene Families for WDR55 Gene

Protein Domains for WDR55 Gene

Suggested Antigen Peptide Sequences for WDR55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR55 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat WDR55 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR55: view

Function for WDR55 Gene

Molecular function for WDR55 Gene

UniProtKB/Swiss-Prot Function:
Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

Phenotypes for WDR55 Gene

MGI mutant phenotypes for WDR55:
inferred from 1 alleles
GenomeRNAi human phenotypes for WDR55:
genes like me logo Genes that share phenotypes with WDR55: view

Animal Models for WDR55 Gene

MGI Knock Outs for WDR55:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR55 Gene

Localization for WDR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR55 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for WDR55 Gene COMPARTMENTS Subcellular localization image for WDR55 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for WDR55 Gene

Pathways & Interactions for WDR55 Gene

SuperPathways for WDR55 Gene

No Data Available

Interacting Proteins for WDR55 Gene

Gene Ontology (GO) - Biological Process for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA,ISS --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR55: view

No data available for Pathways by source and SIGNOR curated interactions for WDR55 Gene

Drugs & Compounds for WDR55 Gene

No Compound Related Data Available

Transcripts for WDR55 Gene

Unigene Clusters for WDR55 Gene

WD repeat domain 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR55 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7

Relevant External Links for WDR55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR55 Gene

mRNA expression in normal human tissues for WDR55 Gene

Protein differential expression in normal tissues from HIPED for WDR55 Gene

This gene is overexpressed in Pancreas (33.3), Lung (14.4), and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR55 Gene

SOURCE GeneReport for Unigene cluster for WDR55 Gene Hs.286261

genes like me logo Genes that share expression patterns with WDR55: view

Protein tissue co-expression partners for WDR55 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR55 Gene

Orthologs for WDR55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR55 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR55 35
  • 89.61 (n)
  • 93.22 (a)
WDR55 36
  • 92 (a)
(Canis familiaris)
Mammalia WDR55 35
  • 89.49 (n)
  • 92.72 (a)
WDR55 36
  • 41 (a)
(Mus musculus)
Mammalia Wdr55 35
  • 83.12 (n)
  • 88.25 (a)
Wdr55 16
Wdr55 36
  • 87 (a)
(Pan troglodytes)
Mammalia WDR55 35
  • 99.22 (n)
  • 99.48 (a)
WDR55 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr55 35
  • 84.51 (n)
  • 89.56 (a)
(Monodelphis domestica)
Mammalia WDR55 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia WDR55 36
  • 78 (a)
(Gallus gallus)
Aves WDR55 35
  • 69.8 (n)
  • 68.24 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490380 35
  • 64.52 (n)
  • 65.05 (a)
Str.15755 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15646 35
(Danio rerio)
Actinopterygii wdr55 35
  • 62.17 (n)
  • 63.07 (a)
wdr55 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008286 35
  • 47.89 (n)
  • 37.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14722 35
  • 46.76 (n)
  • 34.93 (a)
CG14722 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y44F5A.1 36
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34260 35
  • 47.95 (n)
  • 38.36 (a)
(Oryza sativa)
Liliopsida Os07g0660700 35
  • 46.78 (n)
  • 39.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
Species with no ortholog for WDR55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR55 Gene

Gene Tree for WDR55 (if available)
Gene Tree for WDR55 (if available)

Paralogs for WDR55 Gene Pseudogenes for WDR55 Gene

genes like me logo Genes that share paralogs with WDR55: view

No data available for Paralogs for WDR55 Gene

Variants for WDR55 Gene

Sequence variations from dbSNP and Humsavar for WDR55 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34342435 - 140,665,060(-) GTCAC(A/G)GGCCG reference, missense
rs2530245 - 140,668,682(-) GAGAC(A/G)GATAC reference, missense, utr-variant-5-prime
rs2286394 - 140,668,959(-) CCCCA(A/G)ACTGA reference, missense
rs35983033 - 140,669,122(-) AGAGG(C/T)AGATG reference, missense
rs3180056 -- 140,669,544(+) GGGCT(C/T)TGAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for WDR55 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV Duplication 19718026

Variation tolerance for WDR55 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.67; 86.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR55 Gene

Disorders for WDR55 Gene

Relevant External Links for WDR55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR55 Gene

Publications for WDR55 Gene

  1. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for WDR55 Gene

Sources for WDR55 Gene