WDR55 Gene
protein-coding GIFtS: 41
GCID: GC05P140044
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|
WD repeat domain 55
| |
Aliases
for WDR55 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 551 2 | | FLJ201951 | | FLJ217021 | | WD Repeat-Containing Protein 552 |
Export aliases for WDR55 gene to outside databasesPrevious GC identifers: GC05P140026 GC05P135189 |
Summaries
for WDR55 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: WDR55_HUMAN, Q9H6Y2Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (Bysimilarity)
|
Genomic Views
for WDR55 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR55 gene promoter:
CREB AP-1 ATF-2 deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR55
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR55 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3WDR55 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P140044: view genomic region
(about GC identifiers)
Start:
|
140,044,261 bp from pter |
End:
|
140,053,709 bp from pter |
Size:
|
9,449 bases |
Orientation:
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plus strand |
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Proteins
for WDR55 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR55_HUMAN, Q9H6Y2 (See
protein sequence)Recommended Name: WD repeat-containing protein 55 Size: 383 amino acids; 42070 Da
Subcellular location: Nucleus, nucleolus (By similarity). Cytoplasm (By similarity)
Secondary accessions: Q9NXK4Alternative splicing: 2 isoforms: Q9H6Y2-1 Q9H6Y2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR55: NX_Q9H6Y2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H6Y2
WDR55 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060176.2
ENSEMBL proteins: ENSP00000351100 ENSP00000426304 ENSP00000439719
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
WDR55 for ontologies About GeneDecksing
WDR55 Antibody Products:
Assay Products for WDR55: |
Protein
Domains /
Families
for WDR55 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR55 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H6Y2ProtoNet protein and cluster: Q9H6Y2 UniProtKB/Swiss-Prot: WDR55_HUMAN, Q9H6Y2Similarity: Belongs to the WD repeat WDR55 familySimilarity: Contains 7 WD repeats |
Function
for WDR55 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WDR55_HUMAN, Q9H6Y2Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR55 (NM_017706) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR55 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR55 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR55 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
WDR55 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Wdr55tm1Matn for WDR55
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Wdr55):
WDR55 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WDR55 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR55
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for WDR55 (ENSP000003511004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006364 | rRNA processing |
ISS | -- | | GO:0008150 | biological_process |
ND | -- |
WDR55 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR55 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR55
Search CenterWatch for drugs/clinical trials and news about WDR55
|
Transcripts
for WDR55 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR55 gene: NM_017706.4 Unigene Cluster for WDR55: WD repeat domain 55 Hs.286261 [show with all ESTs]Unigene Representative Sequence: NM_0177065 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358337(uc003lgr.4 uc011czl.1) ENST00000506393 ENST00000511232
ENST00000504897 ENST00000520764
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR55 (NM_017706) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR55 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR55 |
Additional cDNA sequence: AK000202.1 AK025355.1 AK293417.1 BC041687.1 BC068485.1 FJ423749.1 13 DOTS entries: DT.456090 DT.100682955 DT.95171401 DT.97819569 DT.91719427 DT.100030877 DT.120887657 DT.100668929 DT.100783761 DT.91803062 DT.92420563 DT.120887538 DT.120887686 24/33 AceView cDNA sequences (see all 33): AA573174 BM672415 AI700432 BI334121 CA944461 BX103684 AW449637 BU178095 BF431619 BG008909 H61209 BG008915 BE535907 BM793305 BP359770 BG008921 BG392972 BE897727 BM686421 AK000202 AL524159 BE870867 BP338430 BI061693
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR55 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR55
|
Expression
for WDR55 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR55 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See WDR55 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR55
SOURCE GeneReport for Unigene cluster: Hs.286261
SABiosciences Custom PCR Arrays for WDR55
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR55
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR55 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR55 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR55 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR55 |
Orthologs
for WDR55 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR55 gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for WDR55 (if available)
TreeFam Gene Tree for WDR55 (if available) |
Paralogs
for WDR55 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR55 gene
WDR55 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for WDR55
PGOHUM00000241093
|
Genomic Variants
for WDR55 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR55 (140044261 - 140053709 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR55: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR55 |
|
Disorders
/ Diseases
for WDR55 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR55 for disorders About GeneDecksing
1  disease for WDR55: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: WDR55 (2 documents)
Export disorders for WDR55 gene to outside databases
|
Publications
for WDR55 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR55 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with WDR55) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1 Luke M.M....Psaty B.M. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1 Shiffman D....Psaty B.M. (2008)
|
External Searches for WDR55 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR55 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR55 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR55 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR55 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR55 gene:
Search GeneIP for patents involving WDR55
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR55 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR55 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR55 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR55 | | | OriGene Protein Over-expression Lysate for WDR55 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR55 | | OriGene 3'-UTR Clone for WDR55 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR55 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WDR55 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for WDR55 | | OriGene Custom Protein Services for WDR55 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR55 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR55 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR55 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR55 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR55 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR55 |
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 |  |  |  | |
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 | | | WDR55 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR55 |
|  |  |  | | | | ThermoFisher Antibodies for WDR55 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR55 |
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