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Aliases for WDR55 Gene

Aliases for WDR55 Gene

  • WD Repeat Domain 55 2 3

External Ids for WDR55 Gene

Summaries for WDR55 Gene

GeneCards Summary for WDR55 Gene

WDR55 (WD Repeat Domain 55) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR55 Gene

  • Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR55 Gene

Genomics for WDR55 Gene

Genomic Location for WDR55 Gene

Start:
140,664,676 bp from pter
End:
140,674,124 bp from pter
Size:
9,449 bases
Orientation:
Plus strand

Genomic View for WDR55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR55 Gene

Regulatory Elements for WDR55 Gene

Proteins for WDR55 Gene

  • Protein details for WDR55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y2-WDR55_HUMAN
    Recommended name:
    WD repeat-containing protein 55
    Protein Accession:
    Q9H6Y2
    Secondary Accessions:
    • Q9NXK4

    Protein attributes for WDR55 Gene

    Size:
    383 amino acids
    Molecular mass:
    42070 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR55 Gene

Proteomics data for WDR55 Gene at MOPED

Post-translational modifications for WDR55 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys320

Other Protein References for WDR55 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR55 Gene

Domains for WDR55 Gene

Gene Families for WDR55 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR55 Gene

UniProtKB/Swiss-Prot:

WDR55_HUMAN
Family:
  • Belongs to the WD repeat WDR55 family.:
    • Q9H6Y2
Similarity:
  • Contains 7 WD repeats.:
    • Q9H6Y2
genes like me logo Genes that share domains with WDR55: view

Function for WDR55 Gene

Molecular function for WDR55 Gene

UniProtKB/Swiss-Prot Function: Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with WDR55: view

Phenotypes for WDR55 Gene

MGI mutant phenotypes for WDR55:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with WDR55: view

Animal Models for WDR55 Gene

MGI Knock Outs for WDR55:

miRNA for WDR55 Gene

miRTarBase miRNAs that target WDR55

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for WDR55 Gene

Localization for WDR55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR55 Gene

Nucleus, nucleolus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR55 Gene COMPARTMENTS Subcellular localization image for WDR55 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IBA --
GO:0005730 nucleolus ISS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with WDR55: view

Pathways for WDR55 Gene

SuperPathways for WDR55 Gene

No Data Available

Interacting Proteins for WDR55 Gene

Gene Ontology (GO) - Biological Process for WDR55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing ISS --
GO:0008150 biological_process ND --
GO:0016070 RNA metabolic process IBA --
GO:0042273 ribosomal large subunit biogenesis IBA --
genes like me logo Genes that share ontologies with WDR55: view

No data available for Pathways by source for WDR55 Gene

Transcripts for WDR55 Gene

Unigene Clusters for WDR55 Gene

WD repeat domain 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR55 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7
SP1:
SP2:
SP3:
SP4:

Relevant External Links for WDR55 Gene

GeneLoc Exon Structure for
WDR55
ECgene alternative splicing isoforms for
WDR55

Expression for WDR55 Gene

mRNA expression in normal human tissues for WDR55 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR55 Gene

SOURCE GeneReport for Unigene cluster for WDR55 Gene Hs.286261

genes like me logo Genes that share expressions with WDR55: view

Orthologs for WDR55 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR55 36
  • 99.22 (n)
  • 99.48 (a)
WDR55 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR55 36
  • 89.61 (n)
  • 93.22 (a)
WDR55 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR55 36
  • 89.49 (n)
  • 92.72 (a)
WDR55 37
  • 41 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr55 36
  • 83.12 (n)
  • 88.25 (a)
Wdr55 16
Wdr55 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR55 37
  • 34 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR55 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr55 36
  • 84.51 (n)
  • 89.56 (a)
chicken
(Gallus gallus)
Aves WDR55 36
  • 69.8 (n)
  • 68.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15646 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490380 36
  • 64.52 (n)
  • 65.05 (a)
Str.15755 36
zebrafish
(Danio rerio)
Actinopterygii wdr55 36
  • 62.17 (n)
  • 63.07 (a)
wdr55 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008286 36
  • 47.89 (n)
  • 37.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14722 36
  • 46.76 (n)
  • 34.93 (a)
CG14722 37
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y44F5A.1 37
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G34260 36
  • 47.95 (n)
  • 38.36 (a)
rice
(Oryza sativa)
Liliopsida Os07g0660700 36
  • 46.78 (n)
  • 39.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
OneToOne
Species with no ortholog for WDR55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR55 Gene

ENSEMBL:
Gene Tree for WDR55 (if available)
TreeFam:
Gene Tree for WDR55 (if available)

Paralogs for WDR55 Gene

Pseudogenes.org Pseudogenes for WDR55 Gene

genes like me logo Genes that share paralogs with WDR55: view

No data available for Paralogs for WDR55 Gene

Variants for WDR55 Gene

Sequence variations from dbSNP and Humsavar for WDR55 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2251860 -- 140,668,624(-) AGACT(A/G)TTGAT synonymous-codon, reference, utr-variant-5-prime
rs2286394 - 140,668,959(-) CCCCA(A/G)ACTGA reference, missense
rs2302104 -- 140,668,015(-) TTTGC(A/G)CAAGA intron-variant
rs2530245 - 140,668,682(-) GAGAC(A/G)GATAC missense, reference, utr-variant-5-prime
rs2530246 -- 140,667,426(-) GGAGG(C/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR55 Gene

Variant ID Type Subtype PubMed ID
nsv471435 CNV Duplication 19718026

Relevant External Links for WDR55 Gene

HapMap Linkage Disequilibrium report
WDR55

Disorders for WDR55 Gene

Relevant External Links for WDR55

Genetic Association Database (GAD)
WDR55
Human Genome Epidemiology (HuGE) Navigator
WDR55
genes like me logo Genes that share disorders with WDR55: view

No data available for UniProtKB/Swiss-Prot for WDR55 Gene

Publications for WDR55 Gene

  1. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49
  2. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke M.M. … Psaty B.M. (Stroke 2009) 3 49
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for WDR55 Gene

Sources for WDR55 Gene

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