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Aliases for WDR54 Gene

Aliases for WDR54 Gene

  • WD Repeat Domain 54 2 3 5

External Ids for WDR54 Gene

Previous GeneCards Identifiers for WDR54 Gene

  • GC02P074561
  • GC02P074502
  • GC02P074648
  • GC02P074385

Summaries for WDR54 Gene

GeneCards Summary for WDR54 Gene

WDR54 (WD Repeat Domain 54) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR54 Gene

Genomics for WDR54 Gene

Regulatory Elements for WDR54 Gene

Enhancers for WDR54 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR54 on UCSC Golden Path with GeneCards custom track

Promoters for WDR54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR54 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR54 Gene

Chromosome:
2
Start:
74,421,678 bp from pter
End:
74,425,755 bp from pter
Size:
4,078 bases
Orientation:
Plus strand

Genomic View for WDR54 Gene

Genes around WDR54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR54 Gene

Proteins for WDR54 Gene

  • Protein details for WDR54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H977-WDR54_HUMAN
    Recommended name:
    WD repeat-containing protein 54
    Protein Accession:
    Q9H977
    Secondary Accessions:
    • D6W5I3
    • Q53H85
    • Q86V45

    Protein attributes for WDR54 Gene

    Size:
    334 amino acids
    Molecular mass:
    35891 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR54 Gene

Proteomics data for WDR54 Gene at MOPED

Post-translational modifications for WDR54 Gene

  • Ubiquitination at Lys 266 and Lys 280
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR54 Gene

No data available for DME Specific Peptides for WDR54 Gene

Domains & Families for WDR54 Gene

Gene Families for WDR54 Gene

Protein Domains for WDR54 Gene

Suggested Antigen Peptide Sequences for WDR54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H977

UniProtKB/Swiss-Prot:

WDR54_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR54: view

Function for WDR54 Gene

genes like me logo Genes that share phenotypes with WDR54: view

Animal Model Products

miRNA for WDR54 Gene

miRTarBase miRNAs that target WDR54

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR54 Gene

Localization for WDR54 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR54 Gene COMPARTMENTS Subcellular localization image for WDR54 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR54 Gene

Pathways & Interactions for WDR54 Gene

SuperPathways for WDR54 Gene

No Data Available

Interacting Proteins for WDR54 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000006526%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000340176%0d%0a
Selected Interacting proteins: ENSP00000006526 for WDR54 Gene via STRING

Gene Ontology (GO) - Biological Process for WDR54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR54 Gene

Drugs & Compounds for WDR54 Gene

No Compound Related Data Available

Transcripts for WDR54 Gene

Unigene Clusters for WDR54 Gene

WD repeat domain 54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR54 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - -
SP12: -
SP13:
SP14: -

ExUns: 10a · 10b
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for WDR54 Gene

GeneLoc Exon Structure for
WDR54
ECgene alternative splicing isoforms for
WDR54

Expression for WDR54 Gene

mRNA expression in normal human tissues for WDR54 Gene

Protein differential expression in normal tissues from HIPED for WDR54 Gene

This gene is overexpressed in Retina (33.2) and Testis (22.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR54 Gene



SOURCE GeneReport for Unigene cluster for WDR54 Gene Hs.643480

genes like me logo Genes that share expression patterns with WDR54: view

Protein tissue co-expression partners for WDR54 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR54 Gene

Orthologs for WDR54 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR54 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR54 35
  • 88.72 (n)
  • 88.82 (a)
WDR54 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR54 35
  • 88.69 (n)
  • 89.79 (a)
WDR54 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr54 35
  • 85.73 (n)
  • 88.62 (a)
Wdr54 16
Wdr54 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR54 35
  • 99.7 (n)
  • 99.4 (a)
WDR54 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr54 35
  • 86.03 (n)
  • 88.32 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR54 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR54 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751597 35
  • 66.16 (n)
  • 62.35 (a)
WDR54 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR54 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wdr54 35
  • 60.24 (n)
  • 56.63 (a)
wdr54 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F39H12.2 36
  • 23 (a)
OneToOne
Species with no ortholog for WDR54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for WDR54 Gene

ENSEMBL:
Gene Tree for WDR54 (if available)
TreeFam:
Gene Tree for WDR54 (if available)

Paralogs for WDR54 Gene

No data available for Paralogs for WDR54 Gene

Variants for WDR54 Gene

Sequence variations from dbSNP and Humsavar for WDR54 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1060523 -- 74,424,474(-) CTATG(A/C)CAGGT intron-variant
rs1060524 -- 74,424,174(-) TCTTA(A/G)TTAAC intron-variant
rs3732293 -- 74,422,807(+) AAAAA(A/C)AAACA intron-variant
rs7607995 -- 74,424,186(+) TTTAT(A/C)ATACT intron-variant
rs2268422 -- 74,424,168(-) TTAAC(C/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR54 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Variation tolerance for WDR54 Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.25; 40.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR54 Gene

Disorders for WDR54 Gene

Relevant External Links for WDR54

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR54

No disorders were found for WDR54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR54 Gene

Publications for WDR54 Gene

  1. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for WDR54 Gene

Sources for WDR54 Gene

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