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Aliases for WDR53 Gene

Aliases for WDR53 Gene

  • WD Repeat Domain 53 2 3 5

External Ids for WDR53 Gene

Previous GeneCards Identifiers for WDR53 Gene

  • GC03M197770
  • GC03M196281
  • GC03M193578

Summaries for WDR53 Gene

Entrez Gene Summary for WDR53 Gene

  • This gene encodes a protein containing WD domains. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR53 Gene

WDR53 (WD Repeat Domain 53) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR53 Gene

Genomics for WDR53 Gene

Regulatory Elements for WDR53 Gene

Enhancers for WDR53 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196527 1.7 FANTOM5 ENCODE dbSUPER 11.6 +40.1 40131 1.8 PKNOX1 ATF1 CREB3L1 ARNT SIN3A YY1 TCF12 ZNF121 GTF3C2 ZNF766 FBXO45 RNF168 SDHAP2 LINC00969 ENSG00000230732 WDR53 MUC20P1 UBXN7 CEP19 NCBP2
GH03G197215 1.4 Ensembl ENCODE 10.1 -647.7 -647729 1.3 HNRNPUL1 HDGF PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 YY1 ENSG00000234742 RNF168 UBXN7 LOC220729 MELTF-AS1 ENSG00000230732 WDR53 MELTF GC03P197175 MIR4797
GH03G196532 0.8 ENCODE 11.9 +35.4 35357 0.9 HDAC1 ZNF146 TEAD4 ZIC2 GLIS2 GATA3 GATA2 ZNF600 PRDM10 SMARCE1 FBXO45 RNF168 WDR53 MELTF-AS1 ENSG00000213358 RPS29P3
GH03G196135 1.6 Ensembl ENCODE dbSUPER 5.7 +427.5 427455 11.4 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 FOS SLC51A LINC00885 WDR53 GC03M196081
GH03G196406 0.8 ENCODE 9.8 +161.8 161838 0.5 NFIB ZFP64 ZNF140 ZNF266 BCL11B ZNF101 ZNF697 ZNF791 ZNF433 ZNF680 MELTF-AS1 UBXN7 SDHAP2 UBXN7-AS1 ENSG00000229178 TM4SF19 RNU6-910P NCBP2 LINC00969 ENSG00000230732
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR53 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR53 Gene

Chromosome:
3
Start:
196,554,177 bp from pter
End:
196,568,674 bp from pter
Size:
14,498 bases
Orientation:
Minus strand

Genomic View for WDR53 Gene

Genes around WDR53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR53 Gene

Proteins for WDR53 Gene

  • Protein details for WDR53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5U6-WDR53_HUMAN
    Recommended name:
    WD repeat-containing protein 53
    Protein Accession:
    Q7Z5U6
    Secondary Accessions:
    • A0MNP1

    Protein attributes for WDR53 Gene

    Size:
    358 amino acids
    Molecular mass:
    38989 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR53 Gene

Post-translational modifications for WDR53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR53 Gene

Domains & Families for WDR53 Gene

Gene Families for WDR53 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z5U6

UniProtKB/Swiss-Prot:

WDR53_HUMAN :
  • Belongs to the WD repeat WDR53 family.
Family:
  • Belongs to the WD repeat WDR53 family.
genes like me logo Genes that share domains with WDR53: view

Function for WDR53 Gene

genes like me logo Genes that share phenotypes with WDR53: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR53 Gene

Localization for WDR53 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR53 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for WDR53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with WDR53: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR53 Gene

Pathways & Interactions for WDR53 Gene

SuperPathways for WDR53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR53 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR53 Gene

Drugs & Compounds for WDR53 Gene

No Compound Related Data Available

Transcripts for WDR53 Gene

Unigene Clusters for WDR53 Gene

WD repeat domain 53:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR53 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c
SP1: - - - - - - -
SP2: -
SP3: -
SP4:
SP5: - - - - - - - -
SP6: - -

Relevant External Links for WDR53 Gene

GeneLoc Exon Structure for
WDR53
ECgene alternative splicing isoforms for
WDR53

Expression for WDR53 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR53 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for WDR53 Gene

This gene is overexpressed in Testis (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR53 Gene



Protein tissue co-expression partners for WDR53 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR53 Gene:

WDR53

SOURCE GeneReport for Unigene cluster for WDR53 Gene:

Hs.385865

Evidence on tissue expression from TISSUES for WDR53 Gene

  • Nervous system(4.2)
  • Eye(4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with WDR53: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR53 Gene

Orthologs for WDR53 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR53 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR53 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia WDR53 34 35
  • 90.41 (n)
cow
(Bos Taurus)
Mammalia WDR53 34 35
  • 89.11 (n)
mouse
(Mus musculus)
Mammalia Wdr53 34 16 35
  • 84.17 (n)
rat
(Rattus norvegicus)
Mammalia Wdr53 34
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR53 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR53 34 35
  • 63.74 (n)
lizard
(Anolis carolinensis)
Reptilia WDR53 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr53 34
  • 62.97 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC799626 34
  • 54.62 (n)
WDR53 35
  • 47 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45760 34
  • 45.46 (n)
rice
(Oryza sativa)
Liliopsida Os01g0205100 34
  • 44.41 (n)
Species where no ortholog for WDR53 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR53 Gene

ENSEMBL:
Gene Tree for WDR53 (if available)
TreeFam:
Gene Tree for WDR53 (if available)

Paralogs for WDR53 Gene

Pseudogenes.org Pseudogenes for WDR53 Gene

genes like me logo Genes that share paralogs with WDR53: view

No data available for Paralogs for WDR53 Gene

Variants for WDR53 Gene

Sequence variations from dbSNP and Humsavar for WDR53 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035890 A breast cancer sample
rs1000212234 -- 196,563,754(+) TTTAG(G/T)AGAGA intron-variant
rs1000301780 -- 196,557,417(+) GGCTT(G/T)TGCCT intron-variant
rs1000339568 -- 196,566,668(+) TTCGG(C/T)CTCCC intron-variant
rs1000662036 -- 196,558,478(+) CTGGG(A/G)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR53 Gene

Variant ID Type Subtype PubMed ID
nsv1003066 CNV gain 25217958
nsv1014692 CNV gain 25217958
nsv1139198 CNV deletion 24896259
nsv829828 CNV loss 17160897

Variation tolerance for WDR53 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR53 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR53

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR53 Gene

Disorders for WDR53 Gene

Relevant External Links for WDR53

Human Genome Epidemiology (HuGE) Navigator
WDR53
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR53

No disorders were found for WDR53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR53 Gene

Publications for WDR53 Gene

  1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for WDR53 Gene

Sources for WDR53 Gene

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