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Aliases for WDR53 Gene

Aliases for WDR53 Gene

  • WD Repeat Domain 53 2 3 5

External Ids for WDR53 Gene

Previous GeneCards Identifiers for WDR53 Gene

  • GC03M197770
  • GC03M196281
  • GC03M193578

Summaries for WDR53 Gene

Entrez Gene Summary for WDR53 Gene

  • This gene encodes a protein containing WD domains. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR53 Gene

WDR53 (WD Repeat Domain 53) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR53 Gene

Genomics for WDR53 Gene

Regulatory Elements for WDR53 Gene

Enhancers for WDR53 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR53 on UCSC Golden Path with GeneCards custom track

Promoters for WDR53 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR53 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR53 Gene

196,554,177 bp from pter
196,568,674 bp from pter
14,498 bases
Minus strand

Genomic View for WDR53 Gene

Genes around WDR53 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR53 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR53 Gene

Proteins for WDR53 Gene

  • Protein details for WDR53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 53
    Protein Accession:
    Secondary Accessions:
    • A0MNP1

    Protein attributes for WDR53 Gene

    358 amino acids
    Molecular mass:
    38989 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR53 Gene

Proteomics data for WDR53 Gene at MOPED

Post-translational modifications for WDR53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR53 Gene

No data available for DME Specific Peptides for WDR53 Gene

Domains & Families for WDR53 Gene

Gene Families for WDR53 Gene

Protein Domains for WDR53 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR53 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat WDR53 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR53: view

Function for WDR53 Gene

genes like me logo Genes that share phenotypes with WDR53: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR53 Gene

Localization for WDR53 Gene

Subcellular locations from

Jensen Localization Image for WDR53 Gene COMPARTMENTS Subcellular localization image for WDR53 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR53 Gene

Pathways & Interactions for WDR53 Gene

SuperPathways for WDR53 Gene

No Data Available

Interacting Proteins for WDR53 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000328079 Q7Z5U6-WDR53_HUMAN for WDR53 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for WDR53 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR53 Gene

Drugs & Compounds for WDR53 Gene

No Compound Related Data Available

Transcripts for WDR53 Gene

Unigene Clusters for WDR53 Gene

WD repeat domain 53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR53 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c
SP1: - - - - - - -
SP2: -
SP3: -
SP5: - - - - - - - -
SP6: - -

Relevant External Links for WDR53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR53 Gene

mRNA expression in normal human tissues for WDR53 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR53 Gene

This gene is overexpressed in Testis (x6.6).

Protein differential expression in normal tissues from HIPED for WDR53 Gene

This gene is overexpressed in Testis (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR53 Gene

SOURCE GeneReport for Unigene cluster for WDR53 Gene Hs.385865

genes like me logo Genes that share expression patterns with WDR53: view

Protein tissue co-expression partners for WDR53 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WDR53 Gene

Orthologs for WDR53 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR53 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR53 35
  • 89.11 (n)
  • 87.43 (a)
WDR53 36
  • 88 (a)
(Canis familiaris)
Mammalia WDR53 35
  • 90.41 (n)
  • 89.94 (a)
WDR53 36
  • 90 (a)
(Mus musculus)
Mammalia Wdr53 35
  • 84.17 (n)
  • 83.52 (a)
Wdr53 16
Wdr53 36
  • 84 (a)
(Pan troglodytes)
Mammalia WDR53 35
  • 99.81 (n)
  • 99.72 (a)
WDR53 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Wdr53 35
  • 82.96 (n)
  • 82.12 (a)
(Monodelphis domestica)
Mammalia WDR53 36
  • 77 (a)
(Gallus gallus)
Aves WDR53 35
  • 63.74 (n)
  • 63.17 (a)
WDR53 36
  • 63 (a)
(Anolis carolinensis)
Reptilia WDR53 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr53 35
  • 62.97 (n)
  • 57.95 (a)
(Danio rerio)
Actinopterygii LOC799626 35
  • 54.62 (n)
  • 50.14 (a)
WDR53 36
  • 47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45760 35
  • 45.46 (n)
  • 36.72 (a)
(Oryza sativa)
Liliopsida Os01g0205100 35
  • 44.41 (n)
  • 33.89 (a)
Species with no ortholog for WDR53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR53 Gene

Gene Tree for WDR53 (if available)
Gene Tree for WDR53 (if available)

Paralogs for WDR53 Gene Pseudogenes for WDR53 Gene

genes like me logo Genes that share paralogs with WDR53: view

No data available for Paralogs for WDR53 Gene

Variants for WDR53 Gene

Sequence variations from dbSNP and Humsavar for WDR53 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1048032 - 196,554,275(-) GGGAC(A/C)CCAAA reference, missense
VAR_035890 A breast cancer sample
rs9311 -- 196,554,337(-) TTACC(A/G)AAGCT reference, synonymous-codon
rs1355533 -- 196,559,784(-) CTCTA(A/G)GATGA intron-variant
rs9813420 -- 196,559,275(+) TAGGA(C/G)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR53 Gene

Variant ID Type Subtype PubMed ID
dgv5375n71 CNV Gain 21882294
nsv829828 CNV Loss 17160897

Variation tolerance for WDR53 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR53 Gene

Disorders for WDR53 Gene

Relevant External Links for WDR53

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR53 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR53 Gene

Publications for WDR53 Gene

  1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. (PMID: 17041588) Higa L.A. … Zhang H. (Nat. Cell Biol. 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for WDR53 Gene

Sources for WDR53 Gene