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Aliases for WDR5 Gene

Aliases for WDR5 Gene

  • WD Repeat Domain 5 2 3
  • Cilia And Flagella Associated Protein 89 2 3
  • BMP2-Induced 3-Kb Gene Protein 3 4
  • SWD3 2 3
  • SWD3, Set1c WD40 Repeat Protein, Homolog 3
  • WD Repeat-Containing Protein 5 3
  • Set1c WD40 Repeat Protein 2
  • Homolog (S. Cerevisiae) 2
  • WD-Repeat Protein 5 3
  • CFAP89 3
  • BIG-3 3
  • BIG3 4

External Ids for WDR5 Gene

Summaries for WDR5 Gene

Entrez Gene Summary for WDR5 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5 Gene

WDR5 (WD Repeat Domain 5) is a Protein Coding gene. Among its related pathways are Circadian rhythm pathway and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and histone acetyltransferase activity (H4-K8 specific). An important paralog of this gene is ATG16L1.

UniProtKB/Swiss-Prot for WDR5 Gene

  • Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

Gene Wiki entry for WDR5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5 Gene

Genomics for WDR5 Gene

Genomic Location for WDR5 Gene

Start:
134,135,365 bp from pter
End:
134,159,972 bp from pter
Size:
24,608 bases
Orientation:
Plus strand

Genomic View for WDR5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5 Gene

Regulatory Elements for WDR5 Gene

Proteins for WDR5 Gene

  • Protein details for WDR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61964-WDR5_HUMAN
    Recommended name:
    WD repeat-containing protein 5
    Protein Accession:
    P61964
    Secondary Accessions:
    • Q91VA5
    • Q9NWX7
    • Q9UGP9

    Protein attributes for WDR5 Gene

    Size:
    334 amino acids
    Molecular mass:
    36588 Da
    Quaternary structure:
    • Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component ofthe ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.
    SequenceCaution:
    • Sequence=CAB66159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WDR5 Gene

neXtProt entry for WDR5 Gene

Proteomics data for WDR5 Gene at MOPED

Post-translational modifications for WDR5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys27, Lys32, and Lys227

Other Protein References for WDR5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR5 Gene

Domains for WDR5 Gene

Gene Families for WDR5 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDR5_HUMAN
Family:
  • Belongs to the WD repeat WDR5/wds family.:
    • P61964
Similarity:
  • Contains 7 WD repeats.:
    • P61964
genes like me logo Genes that share domains with WDR5: view

Function for WDR5 Gene

Molecular function for WDR5 Gene

UniProtKB/Swiss-Prot Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

Gene Ontology (GO) - Molecular Function for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12670868
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
GO:0043996 contributes_to histone acetyltransferase activity (H4-K8 specific) IDA 20018852
GO:0046972 contributes_to histone acetyltransferase activity (H4-K16 specific) IDA 20018852
genes like me logo Genes that share ontologies with WDR5: view

Phenotypes for WDR5 Gene

genes like me logo Genes that share phenotypes with WDR5: view

miRNA for WDR5 Gene

miRTarBase miRNAs that target WDR5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR5 Gene

Localization for WDR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR5 Gene COMPARTMENTS Subcellular localization image for WDR5 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005622 intracellular --
GO:0005634 nucleus IDA 17500065
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
genes like me logo Genes that share ontologies with WDR5: view

Pathways for WDR5 Gene

genes like me logo Genes that share pathways with WDR5: view

Pathways by source for WDR5 Gene

1 BioSystems pathway for WDR5 Gene

Gene Ontology (GO) - Biological Process for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with WDR5: view

Transcripts for WDR5 Gene

Unigene Clusters for WDR5 Gene

WD repeat domain 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for WDR5 Gene

GeneLoc Exon Structure for
WDR5
ECgene alternative splicing isoforms for
WDR5

Expression for WDR5 Gene

mRNA expression in normal human tissues for WDR5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR5 Gene

SOURCE GeneReport for Unigene cluster for WDR5 Gene Hs.397638

genes like me logo Genes that share expressions with WDR5: view

Orthologs for WDR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR5 36
  • 99.5 (n)
  • 100 (a)
WDR5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR5 36
  • 88.02 (n)
  • 99.7 (a)
WDR5 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR5 36
  • 89.02 (n)
  • 100 (a)
WDR5 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr5 36
  • 87.62 (n)
  • 100 (a)
Wdr5 16
Wdr5 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Wdr5 36
  • 88.32 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves WDR5 36
  • 84.63 (n)
  • 96.71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr5 36
  • 80.54 (n)
  • 97.01 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr5 36
  • 81.84 (n)
  • 95.81 (a)
wdr5 37
  • 96 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012731 36
  • 73.98 (n)
  • 91.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta wds 36
  • 73.46 (n)
  • 91.22 (a)
wds 37
  • 80 (a)
OneToMany
CG10931 38
  • 56 (a)
wds 38
  • 94 (a)
worm
(Caenorhabditis elegans)
Secernentea wdr-5.1 36
  • 63.09 (n)
  • 70.03 (a)
wdr-5.1 37
  • 61 (a)
ManyToMany
wdr-5.2 37
  • 48 (a)
ManyToMany
wdr-5.3 37
  • 36 (a)
ManyToMany
ZC302.2 38
  • 56 (a)
K04G11.4 38
  • 58 (a)
C14B1.4 38
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49660 36
  • 62.24 (n)
  • 67.01 (a)
rice
(Oryza sativa)
Liliopsida Os03g0725400 36
  • 61.19 (n)
  • 62.42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 37
  • 79 (a)
OneToMany
Species with no ortholog for WDR5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5 Gene

ENSEMBL:
Gene Tree for WDR5 (if available)
TreeFam:
Gene Tree for WDR5 (if available)

Paralogs for WDR5 Gene

Selected SIMAP similar genes for WDR5 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for WDR5 Gene

genes like me logo Genes that share paralogs with WDR5: view

Variants for WDR5 Gene

Sequence variations from dbSNP and Humsavar for WDR5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1128044 -- 134,159,126(+) TGGCA(C/G)TGTGG utr-variant-3-prime
rs4130591 -- 134,144,569(-) AGACA(C/T)GGCAC intron-variant
rs4130592 -- 134,144,454(-) GGCCT(C/T)TAGGA intron-variant
rs11556387 -- 134,158,945(+) TGTGG(C/G/T)ATGGT utr-variant-3-prime
rs11556388 -- 134,159,283(+) CACAG(A/G)TGCCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv825148 CNV Gain 20364138
nsv6751 CNV Loss 18451855

Relevant External Links for WDR5 Gene

HapMap Linkage Disequilibrium report
WDR5
Human Gene Mutation Database (HGMD)
WDR5

Disorders for WDR5 Gene

(1) University of Copenhagen DISEASES for WDR5 Gene

(1) Novoseek inferred disease relationships for WDR5 Gene

Disease -log(P) Hits PubMed IDs
leukemia 46.3 1

Relevant External Links for WDR5

Genetic Association Database (GAD)
WDR5
Human Genome Epidemiology (HuGE) Navigator
WDR5
genes like me logo Genes that share disorders with WDR5: view

No data available for UniProtKB/Swiss-Prot for WDR5 Gene

Publications for WDR5 Gene

  1. Molecular recognition of histone H3 by the WD40 protein WDR5. (PMID: 16829960) Couture J.F. … Trievel R.C. (Nat. Struct. Mol. Biol. 2006) 3 4 23
  2. Structural basis for molecular recognition and presentation of histone H3 by WDR5. (PMID: 16946699) Schuetz A. … Min J. (EMBO J. 2006) 3 4 23
  3. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. (PMID: 18829459) Patel A. … Cosgrove M.S. (J. Biol. Chem. 2008) 3 4 23
  4. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. (PMID: 19556245) Patel A. … Cosgrove M.S. (J. Biol. Chem. 2009) 3 4 23
  5. Cloning and characterization of a novel WD-40 repeat protein that dramatically accelerates osteoblastic differentiation. (PMID: 11551928) Gori F. … Demay M.B. (J. Biol. Chem. 2001) 2 3

Products for WDR5 Gene

  • Addgene plasmids for WDR5

Sources for WDR5 Gene

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