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Aliases for WDR5 Gene

Aliases for WDR5 Gene

  • WD Repeat Domain 5 2 3 5
  • Cilia And Flagella Associated Protein 89 2 3
  • BMP2-Induced 3-Kb Gene Protein 3 4
  • SWD3, Set1c WD40 Repeat Protein, Homolog (S. Cerevisiae) 2
  • SWD3, Set1c WD40 Repeat Protein, Homolog 3
  • WD Repeat-Containing Protein 5 3
  • CFAP89 3
  • BIG-3 3
  • BIG3 4
  • SWD3 3

External Ids for WDR5 Gene

Previous GeneCards Identifiers for WDR5 Gene

  • GC09U990098
  • GC03M123454
  • GC03M123451
  • GC09P134030
  • GC09P135991
  • GC09P137001
  • GC09P106494

Summaries for WDR5 Gene

Entrez Gene Summary for WDR5 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR5 Gene

WDR5 (WD Repeat Domain 5) is a Protein Coding gene. Diseases associated with WDR5 include Kabuki Syndrome 1. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and histone acetyltransferase activity (H4-K8 specific). An important paralog of this gene is WDR5B.

UniProtKB/Swiss-Prot for WDR5 Gene

  • Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

Gene Wiki entry for WDR5 Gene

Additional gene information for WDR5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR5 Gene

Genomics for WDR5 Gene

Regulatory Elements for WDR5 Gene

Enhancers for WDR5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H134162 1.2 ENCODE 62.8 +29.1 29121 3 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 WDR5 BRD3 LOC100130548 REXO4 RPL7A SURF6 ENSG00000273249 MED22 COL5A1-AS1 ENSG00000273473
GH09H134640 1.6 FANTOM5 ENCODE dbSUPER 25.8 +508.9 508941 7 PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 FOS SP3 NFYC TSHZ1 ZNF488 LOC100130548 WDR5 COL5A1 BRD3 C9orf116 GC09P134645
GH09H134363 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +230.9 230874 5 HDGF PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZBTB7B YY1 GLIS2 ZNF207 WDR5 BRD3OS OLFM1 BRD3 RXRA SURF4 COL5A1 MIR4669
GH09H133333 1.2 ENCODE 23.5 -800.1 -800082 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SURF6 GTF3C5 LOC100130548 SETX SURF1 WDR5 TSC1 BRD3 DDX31 GTF3C4
GH09H134369 2 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +243.4 243370 18 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 RXRA ENSG00000273249 LOC100130548 WDR5 BRD3 MIR4669
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR5 on UCSC Golden Path with GeneCards custom track

Promoters for WDR5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242705 635 2001 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ZNF207 DEK SP3

Genomic Location for WDR5 Gene

Chromosome:
9
Start:
134,135,365 bp from pter
End:
134,159,972 bp from pter
Size:
24,608 bases
Orientation:
Plus strand

Genomic View for WDR5 Gene

Genes around WDR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR5 Gene

Proteins for WDR5 Gene

  • Protein details for WDR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61964-WDR5_HUMAN
    Recommended name:
    WD repeat-containing protein 5
    Protein Accession:
    P61964
    Secondary Accessions:
    • Q91VA5
    • Q9NWX7
    • Q9UGP9

    Protein attributes for WDR5 Gene

    Size:
    334 amino acids
    Molecular mass:
    36588 Da
    Quaternary structure:
    • Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component ofthe ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and KAT14. Interacts with histone H3. Interacts with SETD1A. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with PER1.
    SequenceCaution:
    • Sequence=CAB66159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for WDR5 Gene

neXtProt entry for WDR5 Gene

Post-translational modifications for WDR5 Gene

  • Ubiquitination at posLast=3232 and Lys227
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for WDR5 (WDR5)

No data available for DME Specific Peptides for WDR5 Gene

Domains & Families for WDR5 Gene

Suggested Antigen Peptide Sequences for WDR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61964

UniProtKB/Swiss-Prot:

WDR5_HUMAN :
  • Belongs to the WD repeat WDR5/wds family.
Family:
  • Belongs to the WD repeat WDR5/wds family.
genes like me logo Genes that share domains with WDR5: view

Function for WDR5 Gene

Molecular function for WDR5 Gene

UniProtKB/Swiss-Prot Function:
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.

Phenotypes From GWAS Catalog for WDR5 Gene

Gene Ontology (GO) - Molecular Function for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12670868
GO:0018024 histone-lysine N-methyltransferase activity TAS --
GO:0035064 methylated histone binding IDA 16600877
GO:0042800 contributes_to histone methyltransferase activity (H3-K4 specific) IDA 17355966
GO:0043995 contributes_to histone acetyltransferase activity (H4-K5 specific) IDA 20018852
genes like me logo Genes that share ontologies with WDR5: view
genes like me logo Genes that share phenotypes with WDR5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR5
  • Applied Biological Materials Clones for WDR5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR5 Gene

Localization for WDR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR5 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000123 histone acetyltransferase complex IDA 20018852
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 17500065
GO:0005654 nucleoplasm TAS --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IEA,IDA 18838386
genes like me logo Genes that share ontologies with WDR5: view

Pathways & Interactions for WDR5 Gene

genes like me logo Genes that share pathways with WDR5: view

Gene Ontology (GO) - Biological Process for WDR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0031175 neuron projection development IEA --
genes like me logo Genes that share ontologies with WDR5: view

No data available for SIGNOR curated interactions for WDR5 Gene

Drugs & Compounds for WDR5 Gene

(1) Drugs for WDR5 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WDR5 0103 Pharma WD repeat-containing protein 5 (WDR5) antagonist 0

(1) ApexBio Compounds for WDR5 Gene

Compound Action Cas Number
WDR5 0103 WD repeat-containing protein 5 (WDR5) antagonist 890190-22-4
genes like me logo Genes that share compounds with WDR5: view

Drug Products

Transcripts for WDR5 Gene

Unigene Clusters for WDR5 Gene

WD repeat domain 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for WDR5
  • Applied Biological Materials Clones for WDR5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for WDR5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: -
SP3: - - -
SP4: - - - - -
SP5: - -
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for WDR5 Gene

GeneLoc Exon Structure for
WDR5
ECgene alternative splicing isoforms for
WDR5

Expression for WDR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR5 Gene

Protein differential expression in normal tissues from HIPED for WDR5 Gene

This gene is overexpressed in Fetal gut (6.7) and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR5 Gene



Protein tissue co-expression partners for WDR5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR5 Gene:

WDR5

SOURCE GeneReport for Unigene cluster for WDR5 Gene:

Hs.397638

Evidence on tissue expression from TISSUES for WDR5 Gene

  • Lung(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with WDR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR5 Gene

Orthologs for WDR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR5 33 34
  • 99.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia WDR5 33 34
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Wdr5 33
  • 88.32 (n)
cow
(Bos Taurus)
Mammalia WDR5 33 34
  • 88.02 (n)
mouse
(Mus musculus)
Mammalia Wdr5 33 16 34
  • 87.62 (n)
chicken
(Gallus gallus)
Aves WDR5 33
  • 84.63 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr5 33
  • 80.54 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr5 33 34
  • 81.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012731 33
  • 73.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta wds 35 33 34
  • 73.46 (n)
CG10931 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea C14B1.4 35
  • 72 (a)
wdr-5.1 33 34
  • 63.09 (n)
K04G11.4 35
  • 58 (a)
ZC302.2 35
  • 56 (a)
wdr-5.2 34
  • 48 (a)
ManyToMany
wdr-5.3 34
  • 36 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWD3 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G49660 33
  • 62.24 (n)
rice
(Oryza sativa)
Liliopsida Os03g0725400 33
  • 61.19 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2859 34
  • 79 (a)
OneToMany
Species where no ortholog for WDR5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR5 Gene

ENSEMBL:
Gene Tree for WDR5 (if available)
TreeFam:
Gene Tree for WDR5 (if available)

Paralogs for WDR5 Gene

Pseudogenes.org Pseudogenes for WDR5 Gene

genes like me logo Genes that share paralogs with WDR5: view

Variants for WDR5 Gene

Sequence variations from dbSNP and Humsavar for WDR5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs367537994 untested 134,139,896(+) AGAAG(A/C)AGCCC reference, missense
rs1000190511 -- 134,158,391(+) TGGCC(C/G)CGCCA utr-variant-3-prime
rs1000207618 -- 134,159,615(+) CCTCT(G/T)TTTCC utr-variant-3-prime
rs1000248238 -- 134,135,880(+) TGCAT(C/T)AGAAG intron-variant, upstream-variant-2KB
rs1000253775 -- 134,134,966(+) CCTTC(C/G)TGGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR5 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV deletion 23290073
nsv1125319 OTHER inversion 24896259
nsv471848 CNV novel sequence insertion 20440878
nsv473682 CNV novel sequence insertion 20440878
nsv475920 CNV novel sequence insertion 20440878
nsv6751 CNV deletion 18451855
nsv825148 CNV gain 20364138

Variation tolerance for WDR5 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR5 Gene

Human Gene Mutation Database (HGMD)
WDR5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR5 Gene

Disorders for WDR5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for WDR5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search WDR5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for WDR5

Genetic Association Database (GAD)
WDR5
Human Genome Epidemiology (HuGE) Navigator
WDR5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR5
genes like me logo Genes that share disorders with WDR5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WDR5 Gene

Publications for WDR5 Gene

  1. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. (PMID: 19556245) Patel A … Cosgrove MS (The Journal of biological chemistry 2009) 3 4 22 60
  2. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. (PMID: 18829459) Patel A … Cosgrove MS (The Journal of biological chemistry 2008) 3 4 22 60
  3. Structural basis for molecular recognition and presentation of histone H3 by WDR5. (PMID: 16946699) Schuetz A … Min J (The EMBO journal 2006) 3 4 22 60
  4. Molecular recognition of histone H3 by the WD40 protein WDR5. (PMID: 16829960) Couture JF … Trievel RC (Nature structural & molecular biology 2006) 3 4 22 60
  5. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PMID: 20018852) Cai Y … Conaway RC (The Journal of biological chemistry 2010) 3 4 60

Products for WDR5 Gene

  • Addgene plasmids for WDR5

Sources for WDR5 Gene

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