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WDR5 Gene

protein-coding   GIFtS: 65
GCID: GC09P137001

WD Repeat Domain 5

  Search for WDR5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 51 2     BIG-32
SWD31 2     SWD3, Set1c WD40 Repeat Protein, Homolog2
BMP2-Induced 3-Kb Gene Protein2 3     WD Repeat-Containing Protein 52
Homolog (S. Cerevisiae)1     WD-Repeat Protein 52
Set1c WD40 Repeat Protein1     BIG33

External Ids:    HGNC: 127571   Entrez Gene: 110912   Ensembl: ENSG000001963637   OMIM: 6090125   UniProtKB: P619643   

Export aliases for WDR5 gene to outside databases

Previous GC identifers: GC09U990098 GC03M123454 GC03M123451 GC09P134030 GC09P135991 GC09P106494


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR5 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein
contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
(provided by RefSeq, Jul 2008)

GeneCards Summary for WDR5 Gene:
WDR5 (WD repeat domain 5) is a protein-coding gene. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and histone acetyltransferase activity (H4-K8 specific). An important paralog of this gene is NLE1.

UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964
Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient
trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at
'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional
activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several
lysine residues. May regulate osteoblasts differentiation

Gene Wiki entry for WDR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR5 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   E2F-2   STAT5A   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR5 promoter sequence
   Search Chromatin IP Primers for WDR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

WDR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P137001:  view genomic region     (about GC identifiers)

Start:
137,000,487 bp from pter      End:
137,025,094 bp from pter
Size:
24,608 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964 (See protein sequence)
Recommended Name: WD repeat-containing protein 5  
Size: 334 amino acids; 36588 Da
Subunit: Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase
complex to PAX7 and PAX3 (By similarity). Interacts with HCFC1. Component of the ATAC complex, a complex with
histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the
catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component
of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and
MLL4/WBP7. Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone
methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1,
BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6,
PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10
and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3,
MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with KMT2A/MLL1 and RBBP5; the interaction is direct. Component
ofthe ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2,
CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with
histone H3. Interacts with SETD1A. Part of a complex composed at least of ASCL2, C11orf30/EMSY, HCFC1, HSPA8,
CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific
methyltransferase activity (By similarity)
Sequence caution: Sequence=CAB66159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for WDR5 (see all 40):
2CNX (3D)        2CO0 (3D)        2G99 (3D)        2G9A (3D)        2GNQ (3D)        2H13 (3D)    
Secondary accessions: Q91VA5 Q9NWX7 Q9UGP9

Explore the universe of human proteins at neXtProt for WDR5: NX_P61964

Explore proteomics data for WDR5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys27, Lys32, Lys227
  • Modification sites at PhosphoSitePlus

  • See WDR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_060058.1  NP_438172.1  

    ENSEMBL proteins: 
     ENSP00000477000   ENSP00000477449   ENSP00000351446   ENSP00000401889  
    Reactome Protein details: P61964

    WDR5 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for WDR5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P61964

    ProtoNet protein and cluster: P61964

    1 Blocks protein domain: IPB001632 Beta G-protein (transducin) signature

    UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964
    Similarity: Belongs to the WD repeat WDR5/wds family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with WDR5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR5_HUMAN, P61964
    Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient
    trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at
    'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional
    activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several
    lysine residues. May regulate osteoblasts differentiation

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12670868
    GO:0042800contributes to histone methyltransferase activity (H3-K4 specific) IDA17355966
    GO:0043995contributes to histone acetyltransferase activity (H4-K5 specific) IDA--
    GO:0043996contributes to histone acetyltransferase activity (H4-K8 specific) IDA--
    GO:0046972contributes to histone acetyltransferase activity (H4-K16 specific) IDA--
         
    Find genes that share ontologies with WDR5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for WDR5:
     Decreased viability of wild-ty  Wnt reporter downregulated 

    Animal Models:
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    Block miRNA regulation of human, mouse, rat WDR5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR5 (see all 17):
    hsa-miR-607 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-1224-3p hsa-miR-105 hsa-miR-641 hsa-miR-556-3p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidWDR5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat WDR5

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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR5 (NM_017588)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5
    Addgene plasmids for WDR5 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR5_HUMAN, P61964: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000123histone acetyltransferase complex IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA17500065
    GO:0005654nucleoplasm TAS--
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386

    Find genes that share ontologies with WDR5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR5 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Circadian rhythm pathway
    Circadian rhythm pathway


    Find genes that share SuperPaths with WDR5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for WDR5
        Circadian rhythm pathway


    1 Reactome Pathway for WDR5
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Array including WDR5: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for WDR5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR5 (P619641, 2, 3 ENSP000003514464) via UniProtKB, MINT, STRING, and/or I2D (see all 860)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684311, 2, 3EBI-540834,EBI-79722 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2 
    HIST1H3DP684311, 2, 3EBI-540834,EBI-79722 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2 
    HIST1H3EP684311, 2, 3EBI-540834,EBI-79722 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2 
    HIST1H3FP684311, 2, 3EBI-540834,EBI-79722 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2 
    HIST1H3GP684311, 2, 3EBI-540834,EBI-79722 MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0043966histone H3 acetylation IDA18838386

    Find genes that share ontologies with WDR5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR5 gene (2 alternative transcripts): 
    NM_017588.2  NM_052821.3  

    Unigene Cluster for WDR5:

    WD repeat domain 5
    Hs.397638  [show with all ESTs]
    Unigene Representative Sequence: NM_017588
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608937 ENST00000608739 ENST00000358625(uc004cey.3) ENST00000425041(uc004cez.3)

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    hsa-miR-607 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-1224-3p hsa-miR-105 hsa-miR-641 hsa-miR-556-3p hsa-miR-192*
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    Additional mRNA sequence: 

    AJ011376.1 AK000552.1 AK025810.1 BC001635.1 BC015594.1 BC029769.1 

    6 DOTS entries:

    DT.95305451  DT.100751618  DT.95305446  DT.95185967  DT.95305457  DT.100709406 

    Selected AceView cDNA sequences (see all 284):

    BM552859 BF684099 AK000552 AW001984 BM739577 AI457708 AW959835 AA723336 
    BX108002 BM740514 AI375335 BM550000 BQ057275 BM916423 BG390599 AA490411 
    AW410082 BQ058471 BM563219 BQ181882 BU689041 AK024484 BM789741 BU844528 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR5 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
    SP1:                          -     -     -                       -                                                                           
    SP2:                                                              -                                                                           
    SP3:                                -     -                       -                                                                           
    SP4:                    -     -     -     -                       -                                                                           
    SP5:                                      -                       -                                                                           


    ECgene alternative splicing isoforms for WDR5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR5 Expression
    About this image

    WDR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.397638
        Pathway & Disease-focused RT2 Profiler PCR Array including WDR5: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr51 , 5 WD repeat domain 51, 5 87.62(n)1
    100(a)1
      2 (19.38 cM)5
    1408581  NM_080848.21  NP_543124.11 
     275151575 
    chicken
    (Gallus gallus)
    Aves WDR51 WD repeat domain 5 84.63(n)
    96.71(a)
      417144  NM_001006198.1  NP_001006198.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr51 WD repeat domain 5 80.54(n)
    97.01(a)
      496891  NM_001011411.2  NP_001011411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr51 WD repeat domain 5 81.84(n)
    95.81(a)
      406372  NM_213099.1  NP_998264.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wds1 , 3 will die slowly1 94(a)
    (best of 2)3
    73.46(n)1
    91.22(a)1
      3A63
    534281  NM_001258574.11  NP_001245503.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C14B1.43
    wdr-5.11
    guanine nucleotide binding protein3
    wdr-5.11
    72(a)
    (best of 3)3
    63.09(n)1
    70.03(a)1
      III(3777094-3778384)3
    1754741  NM_065348.71  NP_497749.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G496601 AT3G49660 62.24(n)
    67.01(a)
      824128  NM_114826.3  NP_190535.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07254001 Os03g0725400 61.19(n)
    62.42(a)
      4333964  NM_001057665.1  NP_001051130.1 


    ENSEMBL Gene Tree for WDR5 (if available)
    TreeFam Gene Tree for WDR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR5 gene
    NLE12  WDR832  POC1B2  ATG16L12  SNRNP402  WDR5B2  PAFAH1B12  SMU12  
    DAW12  WDR382  ATG16L22  POC1A2  
    Selected SIMAP similar genes for WDR5 using alignment to 3 protein entries:     WDR5_HUMAN (see all proteins) (see all similar genes):
    WDR5B    DAW1    POC1A    DKFZp762M0115    FBXW7    TBL1XR1
    POC1B    SMU1    SPAG16    WDR51B    SNRNP40    WDR57
    WDR38    CDC40    PAFAH1B1    WDR83    WDR88    PLRG1

    Find genes that share paralogs with WDR5           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WDR5
    PGOHUM00000237740 PGOHUM00000245882


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR5 (see all 741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479597061,2
    C--106492218(+) AGAAA-/TGTT  
            
    TGTTT
    1 -- us2k10--------
    rs794275321,2
    F--136999217(+) AACATT/CTTTTT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs287263571,2
    C--136999237(+) GAGACA/GGAGTT 1 -- us2k10--------
    rs287058011,2
    C,F--136999386(+) TCCCAG/AAGTGC 1 -- us2k13Minor allele frequency- A:0.40NA CSA 5
    rs284088601,2
    C,F--136999589(+) AAATAC/TTTTTG 1 -- us2k113Minor allele frequency- T:0.26NA WA CSA EA 381
    rs1474812631,2
    --136999684(+) ATTGAC/GCAGTG 1 -- us2k10--------
    rs287373181,2
    C--136999770(+) TTTAGC/GAGTTT 1 -- us2k1 tfbs30--------
    rs284643041,2
    C,F,H--136999786(+) TTTGGA/GGGTTT 1 -- us2k120Minor allele frequency- G:0.33NS EA NA CSA WA 2343
    rs2003764291,2
    --136999786(+) TTTGG-/AGGTTT 1 -- us2k10--------
    rs1900003131,2
    --136999788(+) TGGAGA/GTTTAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for WDR5 (137000487 - 137025094 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for WDR5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    nsv6751CNV Loss18451855
    nsv825148CNV Gain20364138

    Human Gene Mutation Database (HGMD): WDR5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR5
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609012    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for WDR5:
    Leukemia

    Find genes that share disorders with WDR5           About GenesLikeMe

    1 Novoseek inferred disease relationship for WDR5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 46.3 1 18829459 (1)

    Genetic Association Database (GAD): WDR5
    Human Genome Epidemiology (HuGE) Navigator: WDR5 (3 documents)

    Export disorders for WDR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR5 gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with WDR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular recognition of histone H3 by the WD40 protein WDR5. (PubMed id 16829960)1, 2, 9 Couture J.F.... Trievel R.C. (Nat. Struct. Mol. Biol. 2006)
    2. Structural basis for molecular recognition and presentation of histone H3 by WDR5. (PubMed id 16946699)1, 2, 9 Schuetz A.... Min J. (EMBO J. 2006)
    3. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. (PubMed id 19556245)1, 2, 9 Patel A.... Cosgrove M.S. (J. Biol. Chem. 2009)
    4. Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. (PubMed id 18829459)1, 2, 9 Patel A.... Cosgrove M.S. (J. Biol. Chem. 2008)
    5. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. (PubMed id 20018852)1, 2 Cai Y.... Conaway R.C. (J. Biol. Chem. 2010)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PubMed id 19131338)1, 2 Garapaty S....Samuels H.H. (J. Biol. Chem. 2009)
    8. CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. (PubMed id 18378692)1, 2 Thompson B.A.... Bochar D.A. (Mol. Cell. Biol. 2008)
    9. Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)1, 2 Lee J.H. and Skalnik D.G. (Mol. Cell. Biol. 2008)
    10. WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. (PubMed id 18840606)1, 2 Song J.J. and Kingston R.E. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11091 HGNC: 12757 AceView: WDR5 Ensembl:ENSG00000196363 euGenes: HUgn11091
    ECgene: WDR5 H-InvDB: WDR5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR5 gene:
    Search GeneIP for patents involving WDR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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