Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDR5 Gene

protein-coding GIFtS: 60
GCID: GC09P137001

WD repeat domain 5

Explore 4 diseases affiliated with
WDR5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD Repeat Domain 5¹ ²		SWD3, Set1c WD40 Repeat Protein, Homolog²
SWD3¹ ²		WD Repeat-Containing Protein 5²
BMP2-Induced 3-Kb Gene Protein² ³		WD-Repeat Protein 5²
BIG-3²		BIG3³

External Ids:	HGNC: 12757¹	Entrez Gene: 11091²	Ensembl: ENSG00000196363⁷	OMIM: 609012⁵	UniProtKB: P61964³

Export aliases for WDR5 gene to outside databases

Previous GC identifers: GC09U990098 GC03M123454 GC03M123451 GC09P134030 GC09P135991 GC09P106494

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR5:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately

40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or

multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle

progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively

spliced transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964

Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation

at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.

H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex

it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts

differentiation

Gene Wiki entry for WDR5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_035014.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WDR5 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F E2F-2 STAT5A Tal-1beta E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR5 promoter sequence

Search SABiosciences Chromatin IP Primers for WDR5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34

WDR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR5 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P137001: view genomic region (about GC identifiers)

Start:	137,001,210 bp from pter	End:	137,025,094 bp from pter
Size:	23,885 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964 (See protein sequence)

Recommended Name: WD repeat-containing protein 5

Size: 334 amino acids; 36588 Da

Subunit: Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on

histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B),

WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing

complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7. Each complex is at least composed of

ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (MLL, MLL2/ALR, MLL3 and MLL4/WBP7), and

the facultative components PAGR1, BAP18, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1,

MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4,

TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin. Component of the NSL complex at least composed of MOF/KAT8,

KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with MLL and RBBP5; the interaction is

direct. Component ofthe ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5,

YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with

histone H3. Interacts with SETD1A

Subcellular location: Nucleus

Sequence caution: Sequence=CAB66159.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

6/38 PDB 3D structures from and Proteopedia for WDR5 (see all 38):

2CNX (3D)

2CO0 (3D)

2G99 (3D)

2G9A (3D)

2GNQ (3D)

2H13 (3D)

Secondary accessions: Q91VA5 Q9NWX7 Q9UGP9

Explore the universe of human proteins at neXtProt for WDR5: NX_P61964

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61964

WDR5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_060058.1 NP_438172.1

ENSEMBL proteins:

ENSP00000351446 ENSP00000401889

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): WDR5 OriGene Protein Over-expression Lysate (see all 2): WDR5 OriGene Custom Protein Services for WDR5
	GenScript Custom Purified and Recombinant Proteins Services for WDR5
	Novus Biologicals WDR5 Proteins Novus Biologicals WDR5 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for WDR5
	Uscn Proteins for WDR5

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000123	histone acetyltransferase complex	IDA	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	17500065
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	IDA	18838386
GO:0035097	histone methyltransferase complex	IDA	17500065

WDR5 for ontologies About GeneDecksing

WDR5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of WDR5
	R&D Systems Antibodies for WDR5
	Browse OriGene Antibodies OriGene Custom Antibody Services for WDR5
	GenScript Custom Superior Antibodies Services for WDR5
	Novus Biologicals WDR5 Antibodies
	Abcam antibodies for WDR5
	Uscn Antibodies for WDR5
	ThermoFisher Antibodies for WDR5

Assay Products for WDR5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for WDR5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for WDR5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR5 for domains About GeneDecksing

5 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry P61964

ProtoNet protein and cluster: P61964

1 Blocks protein family: IPB001632 Beta G-protein (transducin) signature

UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964

Similarity: Belongs to the WD repeat WDR5/wds family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: WDR5_HUMAN, P61964

Function: Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation

at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3.

H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex

it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts

differentiation

miRNA Products:		OriGene 3'-UTR Clone (see all 2): WDR5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR5
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR5 (see all 17):
		hsa-miR-607 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-1224-3p hsa-miR-105 hsa-miR-641 hsa-miR-556-3p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: WDR5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR5 (see all 7) OriGene shRNA RFP: WDR5 OriGene siRNA: WDR5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for WDR5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): WDR5 (NM_017588)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for WDR5
		Search LifeMap BioReagents cell lines for WDR5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0042800	contributes to histone methyltransferase activity (H3-K4 specific)	IDA	17355966
GO:0043995	contributes to histone acetyltransferase activity (H4-K5 specific)	IDA	--
GO:0043996	contributes to histone acetyltransferase activity (H4-K8 specific)	IDA	--
GO:0046972	contributes to histone acetyltransferase activity (H4-K16 specific)	IDA	--

WDR5 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for WDR5:

Decreased viability of wild-ty

Wnt reporter downregulated

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Circadian rhythm pathway

Circadian rhythm pathway

1.00

1 BioSystems Pathway for WDR5

Circadian rhythm pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for WDR5

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/753 Interacting proteins for WDR5 (P61964^{1, 2, 3} ENSP00000351446⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 753)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H3C	P68431²^,³	MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2
HIST1H3D	P68431²^,³	MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2
HIST1H3E	P68431²^,³	MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2
HIST1H3F	P68431²^,³	MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2
HIST1H3G	P68431²^,³	MINT-3319352 MINT-3319259 MINT-3319516 MINT-3319451 MINT-3319477 MINT-3293300 MINT-3319546 MINT-3293375 MINT-3293337 I2D: score=2

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001501	skeletal system development	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0043966	histone H3 acetylation	IDA	18838386
GO:0043981	histone H4-K5 acetylation	IDA	--

WDR5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for WDR5
Search CenterWatch for drugs/clinical trials and news about WDR5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for WDR5 gene (2 alternative transcripts):

NM_017588.2 NM_052821.3

Unigene Cluster for WDR5:

WD repeat domain 5

Hs.397638 [show with all ESTs]

Unigene Representative Sequence: NM_017588

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000358625(uc004cey.3) ENST00000425041(uc004cez.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): WDR5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR5
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR5 (see all 17):
		hsa-miR-607 hsa-miR-3607-3p hsa-miR-1226 hsa-miR-1224-3p hsa-miR-105 hsa-miR-641 hsa-miR-556-3p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: WDR5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR5 (see all 7) OriGene shRNA RFP: WDR5 OriGene siRNA: WDR5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): WDR5 (NM_017588)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WDR5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR5

Additional cDNA sequence:

AJ011376.1 AK000552.1 AK025810.1 BC001635.1 BC015594.1 BC029769.1

6 DOTS entries:

DT.95305451 DT.100751618 DT.95305446 DT.95185967 DT.95305457 DT.100709406

24/284 AceView cDNA sequences (see all 284):

AA909811 BF732513 BG390308 BM789741 BU844528 AW410082 BU948461 AI889963

BX502989 AA490411 BX108002 BU684786 BG390599 BM799482 BX102207 AW959835

AK025810 AA723336 BU520921 AI696367 AK024484 AA350464 BF684099 AI457708

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR5 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18
SP1:									-		-		-								-
SP2:																					-
SP3:											-		-								-
SP4:							-		-		-		-								-
SP5:													-								-

ECgene alternative splicing isoforms for WDR5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See WDR5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR5

SOURCE GeneReport for Unigene cluster: Hs.397638

SABiosciences Expression via Pathway-Focused PCR Array including WDR5:

Polycomb & Trithorax Complexes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat WDR5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR5 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	WDR5¹	WD repeat domain 5	84.63(n) 96.71(a)		417144 NM_001006198.1 NP_001006198.1
lizard (Anolis carolinensis)	Reptilia	WDR5B⁶	--	96(a)	1 ↔ 1	GL343736.1(6714-21845)
zebrafish (Danio rerio)	Actinopterygii	wdr5¹	WD repeat domain 5	81.84(n) 95.81(a)		406372 NM_213099.1 NP_998264.1
fruit fly (Drosophila melanogaster)	Insecta	wds^{1 , 3}	will die slowly¹	94(a) (best of 2)³ 73.46(n)¹ 91.22(a)¹		3A6³ 53428¹ NM_080245.4¹ NP_524984.1¹
worm (Caenorhabditis elegans)	Secernentea	C14B1.4³ wdr-5.1¹	guanine nucleotide binding protein³ Protein WDR-5.1¹	72(a) (best of 3)³ 63.09(n)¹ 70.03(a)¹		III(3777094-3778384)³ 175474¹ NM_065348.6¹ NP_497749.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G49660¹	WD40 domain-containing protein	62.24(n) 67.01(a)		824128 NM_114826.3 NP_190535.1
rice (Oryza sativa)	Liliopsida	Os03g0725400¹	hypothetical protein	61.19(n) 62.42(a)		4333964 NM_001057665.1 NP_001051130.1

ENSEMBL Gene Tree for WDR5 (if available)
TreeFam Gene Tree for WDR5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WDR5 gene

POC1B² WDR83² ATG16L1² WDR88² SNRNP40² WDR5B² KATNB1² PAFAH1B1²

PRPF4² DAW1² WDR38² ATG16L2² POC1A² WDSUB1²

18/21 SIMAP similar genes for WDR5 using alignment to 1 protein entry: WDR5_HUMAN(see all similar genes):

WDR5B WDR69 POC1A WDR51A DKFZp762M0115 FBXW7

POC1B TBL1XR1 SMU1 SPAG16 WDR51B SNRNP40

WDR57 WDR38 CDC40 PAFAH1B1 WDR83 WDR88

WDR5 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for WDR5
PGOHUM00000237740 PGOHUM00000245882

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79427532^1,2		--	136999217(+)	`AACATT/CTTTTT`	1	--	us2k¹		1		NA	2
rs28726357^1,2		--	136999237(+)	`GAGACA/GGAGTT`	1	--	us2k¹		0	--	--	--	--
rs28705801^1,2	C,F,	--	136999386(+)	`TCCCAG/AAGTGC`	1	--	us2k¹		3		NA CSA	5
rs28408860^1,2	C,F,	--	136999589(+)	`AAATAC/TTTTTG`	1	--	us2k¹		13		NA WA CSA EA	381
rs147481263^1,2		--	136999684(+)	`ATTGAC/GCAGTG`	1	--	us2k¹		0	--	--	--	--
rs28737318^1,2		--	136999770(+)	`TTTAGC/GAGTTT`	1	--	us2k¹ tfbs³		0	--	--	--	--
rs28464304^1,2	C,F,H,	--	136999786(+)	`TTTGGA/GGGTTT`	1	--	us2k¹		20		NS EA NA CSA WA	2343
rs200376429^1,2		--	136999786(+)	`TTTGG-/AGGTTT`	1	--	us2k¹		0	--	--	--	--
rs190000313^1,2		--	136999788(+)	`TGGAGA/GTTTAG`	1	--	us2k¹		0	--	--	--	--
rs28505536^1,2	C	--	136999859(+)	`GCTGAG/TGTGGG`	1	--	us2k¹		2		NA	4

HapMap Linkage Disequilibrium report for WDR5 (137001210 - 137025094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR5

DNA2.0 Custom Variant and Variant Library Synthesis for WDR5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

WDR5 for disorders           About GeneDecksing

OMIM gene information: 609012    OMIM disorders: --

4 diseases for WDR5:    About MalaCards

breast cancer ataxia leukemia neuronitis

1 disease from the University of Copenhagen DISEASES database for WDR5:

Leukemia

1 Novoseek disease relationship for WDR5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	46.3	1	18829459 (1)

Human Genome Epidemiology (HuGE) Navigator: WDR5 (3 documents)

Export disorders for WDR5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR5 gene, integrated from 9 sources (see all 108):
(articles sorted by number of sources associating them with WDR5)

Utopia: connect your pdf to the dynamic
world of online information

Molecular recognition of histone H3 by the WD40 protein WDR5. (PubMed id 16829960)^{1, 2, 9} Couture J.F.... Trievel R.C. (2006)
Structural basis for molecular recognition and presentation of histone H3 by WDR5. (PubMed id 16946699)^{1, 2, 9} Schuetz A....Min J. (2006)
On the mechanism of multiple lysine methylation by th e human mixed lineage leukemia protein-1 (MLL1) core complex. (PubMed id 19556245)^{1, 2, 9} Patel A....Cosgrove M.S. (2009)
Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide. (PubMed id 18829459)^{1, 2, 9} Patel A.... Cosgrove M.S. (2008)
Subunit composition and substrate specificity of a MO F-containing histone acetyltransferase distinct from the male-specific lethal ( MSL) complex. (PubMed id 20018852)^{1, 2} Cai Y....Conaway R.C. (2010)
CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes. (PubMed id 18378692)^{1, 2} Thompson B.A.... Bochar D.A. (2008)
Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes. (PubMed id 17998332)^{1, 2} Lee J.H. and Skalnik D.G. (2008)
WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. (PubMed id 18840606)^{1, 2} Song J.J. and Kingston R.E. (2008)
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. (PubMed id 18838538)^{1, 2} Wu M....Shilatifard A. (2008)
Identification and characterization of the human Set1B histone H3- Lys4 methyltransferase complex. (PubMed id 17355966)^{1, 2} Lee J.-H.... Skalnik D.G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11091	HGNC: 12757	AceView: WDR5	Ensembl:ENSG00000196363	euGenes: HUgn11091
ECgene: WDR5	H-InvDB: WDR5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR5 gene:
Search GeneIP for patents involving WDR5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of WDR5

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for WDR5 (WDR5)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for WDR5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR5
	OriGene Protein Over-expression Lysate for WDR5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for WDR5		OriGene 3'-UTR Clone for WDR5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for WDR5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for WDR5		OriGene Custom Protein Services for WDR5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR5

	GenScript Custom Purified and Recombinant Proteins Services for WDR5		GenScript cDNA clones with any tag delivered in your preferred vector for WDR5
	GenScript Custom Assay Services for WDR5		GenScript Custom Superior Antibodies Services for WDR5
	GenScript Custom overexpressing Cell Line Services for WDR5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in WDR5 promoter
	Search Chromatin IP Primers for WDR5
	RT² qPCR Primer Assay in human, mouse, rat WDR5
	GNC Network for WDR5
	SABiosciences PCR Arrays including human, mouse, rat WDR5

Search Tocris compounds for WDR5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	WDR5 antibodies
	WDR5 proteins
	WDR5 lysates

	Antibodies for WDR5
	See all of Abcam's Antibodies, Kits and Proteins for WDR5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for WDR5

WDR5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for WDR5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR5

	SwitchGear 3'UTR luciferase reporter plasmids for WDR5
	SwitchGear Promoter luciferase reporter plasmids for WDR5

ThermoFisher Antibodies for WDR5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes WDR5 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

WDR5 Gene

WD repeat domain 5

Aliases
for WDR5 gene

Summaries
for WDR5 gene

Genomic Views
for WDR5 gene

Proteins
for WDR5 gene

Protein Domains /
Families
for WDR5 gene

Function
for WDR5 gene

Pathways & Interactions
for WDR5 gene

Drugs & Compounds
for WDR5 gene

Transcripts
for WDR5 gene

Expression
for WDR5 gene

Orthologs
for WDR5 gene

Paralogs
for WDR5 gene

Genomic Variants
for WDR5 gene

Disorders / Diseases
for WDR5 gene

Publications
for WDR5 gene

External Searches for WDR5 gene

Genome Databases showing WDR5 gene

Other Databases showing WDR5 gene

Specialized Databases showing WDR5 gene

Intellectual Property
for WDR5 gene

Products
for WDR5 gene

View Random Gene

Advanced Search

Export list of displayed genes

WDR5 Gene

WD repeat domain 5

Aliasesfor WDR5 gene

Summariesfor WDR5 gene

Genomic Viewsfor WDR5 gene

Proteinsfor WDR5 gene

Protein Domains /Familiesfor WDR5 gene

Functionfor WDR5 gene

Pathways & Interactionsfor WDR5 gene

Drugs & Compoundsfor WDR5 gene

Transcriptsfor WDR5 gene

Expression for WDR5 gene

Orthologsfor WDR5 gene

Paralogsfor WDR5 gene

Genomic Variantsfor WDR5 gene

Disorders / Diseasesfor WDR5 gene

Publicationsfor WDR5 gene

External Searches for WDR5 gene

Genome Databases showing WDR5 gene

Other Databases showing WDR5 gene

Specialized Databases showing WDR5 gene

Intellectual Propertyfor WDR5 gene

Productsfor WDR5 gene

View Random Gene

Aliases
for WDR5 gene

Summaries
for WDR5 gene

Genomic Views
for WDR5 gene

Proteins
for WDR5 gene

Protein Domains /
Families
for WDR5 gene

Function
for WDR5 gene

Pathways & Interactions
for WDR5 gene

Drugs & Compounds
for WDR5 gene

Transcripts
for WDR5 gene

Expression
for WDR5 gene

Orthologs
for WDR5 gene

Paralogs
for WDR5 gene

Genomic Variants
for WDR5 gene

Disorders / Diseases
for WDR5 gene

Publications
for WDR5 gene

Intellectual Property
for WDR5 gene

Products
for WDR5 gene