Aliases for WDR5 Gene
External Ids for WDR5 Gene
Previous GeneCards Identifiers for WDR5 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for WDR5 Gene
WDR5 (WD Repeat Domain 5) is a Protein Coding gene. Diseases associated with WDR5 include kabuki syndrome 1. Among its related pathways are Chromatin Regulation / Acetylation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include histone methyltransferase activity (H3-K4 specific) and histone acetyltransferase activity (H4-K8 specific). An important paralog of this gene is WDR5B.
UniProtKB/Swiss-Prot for WDR5 Gene
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at Lys-4. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.