Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR49 Gene

Aliases for WDR49 Gene

  • WD Repeat Domain 49 2 3 5

External Ids for WDR49 Gene

Previous GeneCards Identifiers for WDR49 Gene

  • GC03M168680
  • GC03M167196
  • GC03M164566

Summaries for WDR49 Gene

GeneCards Summary for WDR49 Gene

WDR49 (WD Repeat Domain 49) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EFCAB8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR49 Gene

Genomics for WDR49 Gene

Regulatory Elements for WDR49 Gene

Enhancers for WDR49 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F167684 0.6 ENCODE 11.6 -30.6 -30605 0.2 CTCF ZNF654 CEBPB CEBPG RAD21 ATF4 ATF3 CEBPA SMC3 SERPINI1 WDR49 PDCD10 ZBBX HMGN1P8 GC03P167665
GH03F167652 0.8 Ensembl ENCODE 0.8 +0.5 522 2.1 POLR2A BCL11A TEAD4 PRDM1 WDR49 GC03M167593
GH03F167650 0.2 Ensembl 0.8 +3.1 3083 0.6 SERPINI1 WDR49 GC03M167593
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR49 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR49 Gene

167,478,684 bp from pter
167,653,983 bp from pter
175,300 bases
Minus strand

Genomic View for WDR49 Gene

Genes around WDR49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR49 Gene

Proteins for WDR49 Gene

  • Protein details for WDR49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 49
    Protein Accession:
    Secondary Accessions:
    • Q8N297

    Protein attributes for WDR49 Gene

    697 amino acids
    Molecular mass:
    79295 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for WDR49 Gene


neXtProt entry for WDR49 Gene

Post-translational modifications for WDR49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR49 Gene

No data available for DME Specific Peptides for WDR49 Gene

Domains & Families for WDR49 Gene

Gene Families for WDR49 Gene

Suggested Antigen Peptide Sequences for WDR49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 WD repeats.
  • Contains 8 WD repeats.
genes like me logo Genes that share domains with WDR49: view

Function for WDR49 Gene

genes like me logo Genes that share phenotypes with WDR49: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR49 Gene

Localization for WDR49 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR49 gene
Compartment Confidence
cytosol 3
peroxisome 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR49 Gene

Pathways & Interactions for WDR49 Gene

SuperPathways for WDR49 Gene

No Data Available

Interacting Proteins for WDR49 Gene

Selected Interacting proteins: Q8IV35-WDR49_HUMAN for WDR49 Gene via IID

Gene Ontology (GO) - Biological Process for WDR49 Gene


No data available for Pathways by source and SIGNOR curated interactions for WDR49 Gene

Transcripts for WDR49 Gene

mRNA/cDNA for WDR49 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR49 Gene

WD repeat domain 49:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR49 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - - - -
SP4: - - - - - - - - -

Relevant External Links for WDR49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR49 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for WDR49 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WDR49 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Spinal cord (cervical c-1) (x4.9), and Brain - Caudate (basal ganglia) (x4.6).

Protein differential expression in normal tissues from HIPED for WDR49 Gene

This gene is overexpressed in Pancreas (29.9), Peripheral blood mononuclear cells (19.6), and Adipocyte (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WDR49 Gene

Protein tissue co-expression partners for WDR49 Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR49 Gene:


SOURCE GeneReport for Unigene cluster for WDR49 Gene:

genes like me logo Genes that share expression patterns with WDR49: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for WDR49 Gene

Orthologs for WDR49 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR49 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR49 34 35
  • 99.23 (n)
(Canis familiaris)
Mammalia WDR49 34 35
  • 86.9 (n)
(Mus musculus)
Mammalia Wdr49 34 16 35
  • 82.23 (n)
(Rattus norvegicus)
Mammalia Wdr49 34
  • 81.82 (n)
(Bos Taurus)
Mammalia WDR49 35
  • 71 (a)
MGC151671 34
(Monodelphis domestica)
Mammalia WDR49 35
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia WDR49 35
  • 54 (a)
(Anolis carolinensis)
Reptilia WDR49 35
  • 35 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr49 34
  • 63.38 (n)
Str.13668 34
(Danio rerio)
Actinopterygii si:dkey-202c14.3 35
  • 16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40583 35
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 12 (a)
Species where no ortholog for WDR49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR49 Gene

Gene Tree for WDR49 (if available)
Gene Tree for WDR49 (if available)

Paralogs for WDR49 Gene

Paralogs for WDR49 Gene Pseudogenes for WDR49 Gene

genes like me logo Genes that share paralogs with WDR49: view

Variants for WDR49 Gene

Sequence variations from dbSNP and Humsavar for WDR49 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs74903439 A colorectal cancer sample 167,604,375(+) TAAGA(C/T)GCTTT reference, missense
rs193921101 Uncertain significance 167,527,959(-) AAGAT(A/C)ATTCC reference, stop-gained
rs10451921 -- 167,575,372(+) GGCTG(A/C/T)GGAGC intron-variant
rs10537191 -- 167,522,012(+) TAGAT(-/AGATAGA)TTGTT intron-variant
rs10634534 -- 167,497,891(+) TTTTT(-/TT)CAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR49 Gene

Variant ID Type Subtype PubMed ID
nsv592497 CNV loss 21841781
nsv592495 CNV gain 21841781
esv3598566 CNV loss 21293372
esv3432110 CNV insertion 20981092
esv26146 CNV loss 19812545
dgv8727n54 CNV loss 21841781

Variation tolerance for WDR49 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.22; 88.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR49 Gene

Disorders for WDR49 Gene

Relevant External Links for WDR49

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR49 Gene

Publications for WDR49 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64

Products for WDR49 Gene

Sources for WDR49 Gene

Loading form....