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Aliases for WDR47 Gene

Aliases for WDR47 Gene

  • WD Repeat Domain 47 2 3 5
  • Neuronal Enriched MAP-Interacting Protein 3 4
  • Nemitin 3 4
  • WD Repeat-Containing Protein 47 3
  • KIAA0893 4

External Ids for WDR47 Gene

Previous GeneCards Identifiers for WDR47 Gene

  • GC01M109225
  • GC01M109314
  • GC01M109512
  • GC01M107405

Summaries for WDR47 Gene

GeneCards Summary for WDR47 Gene

WDR47 (WD Repeat Domain 47) is a Protein Coding gene. An important paralog of this gene is GNB5.

Gene Wiki entry for WDR47 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR47 Gene

Genomics for WDR47 Gene

Regulatory Elements for WDR47 Gene

Enhancers for WDR47 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F108913 0.9 ENCODE 10.8 +128.9 128895 0.2 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 CHAMP1 GATA2 ZNF263 POLR2H SMARCA4 AKNAD1 SPATA42 WDR47 RANP5 GPSM2 GC01P108959
GH01F109088 1.2 ENCODE 9.9 -48.9 -48854 4.6 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 C1orf194 ENSG00000258634 RPL17P7 RPS27P6 GNAI3 PRPF38B GSTM2 RANP5 WDR47 TMEM167B
GH01F108961 0.5 ENCODE 6.7 +79.0 79037 2.6 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 GNAI3 RPL17P7 PRPF38B RPS27P6 C1orf194 WDR47 TAF13 ENSG00000274068 GC01P108959
GH01F109040 0.4 ENCODE 6 +0.7 748 2.5 PKNOX1 ARID4B SIN3A DMAP1 SLC30A9 CBX5 ZNF207 KLF13 ZNF263 SP3 WDR47 GC01P109031
GH01F108827 0.9 Ensembl ENCODE 5.6 +212.0 212011 4.8 PKNOX1 SIN3A ZNF2 YY1 CBX5 FOS ZNF263 SP5 JUNB REST GPSM2 AKNAD1 SPATA42 WDR47 HENMT1 LOC105378891 GC01P108791
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR47 on UCSC Golden Path with GeneCards custom track

Promoters for WDR47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000284253 728 3000 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 SLC30A9 CBX5 ZNF207 KLF13 ZNF263

Genomic Location for WDR47 Gene

Chromosome:
1
Start:
108,970,211 bp from pter
End:
109,042,228 bp from pter
Size:
72,018 bases
Orientation:
Minus strand

Genomic View for WDR47 Gene

Genes around WDR47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR47 Gene

Proteins for WDR47 Gene

  • Protein details for WDR47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94967-WDR47_HUMAN
    Recommended name:
    WD repeat-containing protein 47
    Protein Accession:
    O94967
    Secondary Accessions:
    • A8MX09
    • Q5TYV7
    • Q5TYV8
    • Q5TYV9
    • Q8IXT7
    • Q8IYU9

    Protein attributes for WDR47 Gene

    Size:
    919 amino acids
    Molecular mass:
    101949 Da
    Quaternary structure:
    • Interacts with MAP1S (via WD repeats).
    SequenceCaution:
    • Sequence=AK225781; Type=Frameshift; Positions=416; Evidence={ECO:0000305}; Sequence=BAA74916.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR47 Gene

Post-translational modifications for WDR47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR47 Gene

Domains & Families for WDR47 Gene

Gene Families for WDR47 Gene

Suggested Antigen Peptide Sequences for WDR47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94967

UniProtKB/Swiss-Prot:

WDR47_HUMAN :
  • Contains 1 CTLH domain.
  • Contains 7 WD repeats.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR47: view

Function for WDR47 Gene

Gene Ontology (GO) - Molecular Function for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with WDR47: view
genes like me logo Genes that share phenotypes with WDR47: view

Animal Models for WDR47 Gene

MGI Knock Outs for WDR47:

Animal Model Products

miRNA for WDR47 Gene

miRTarBase miRNAs that target WDR47

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR47 Gene

Localization for WDR47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR47 Gene

Cytoplasm, cytoskeleton. Note=Localization along microtubules is mediated by MAP1S. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR47 Gene COMPARTMENTS Subcellular localization image for WDR47 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with WDR47: view

Pathways & Interactions for WDR47 Gene

SuperPathways for WDR47 Gene

No Data Available

Interacting Proteins for WDR47 Gene

Gene Ontology (GO) - Biological Process for WDR47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with WDR47: view

No data available for Pathways by source and SIGNOR curated interactions for WDR47 Gene

Transcripts for WDR47 Gene

Unigene Clusters for WDR47 Gene

WD repeat domain 47:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for WDR47 Gene

GeneLoc Exon Structure for
WDR47
ECgene alternative splicing isoforms for
WDR47

Expression for WDR47 Gene

mRNA expression in normal human tissues for WDR47 Gene

mRNA differential expression in normal tissues according to GTEx for WDR47 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for WDR47 Gene

This gene is overexpressed in Fetal Brain (30.0), Frontal cortex (20.2), and Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR47 Gene



Protein tissue co-expression partners for WDR47 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR47 Gene:

WDR47

SOURCE GeneReport for Unigene cluster for WDR47 Gene:

Hs.570055
genes like me logo Genes that share expression patterns with WDR47: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR47 Gene

Orthologs for WDR47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR47 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia WDR47 34 35
  • 94.35 (n)
cow
(Bos Taurus)
Mammalia WDR47 34 35
  • 94.2 (n)
mouse
(Mus musculus)
Mammalia Wdr47 34 16 35
  • 90.22 (n)
rat
(Rattus norvegicus)
Mammalia Wdr47 34
  • 89.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR47 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR47 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR47 34 35
  • 81.77 (n)
lizard
(Anolis carolinensis)
Reptilia WDR47 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr47 34
  • 71.93 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr47b 35
  • 71 (a)
OneToMany
wdr47a 34 35
  • 68.61 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14134 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006113 34
  • 55.08 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2812 34 35
  • 54.05 (n)
worm
(Caenorhabditis elegans)
Secernentea nmtn-1 34 35
  • 52.24 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE4 35
  • 20 (a)
OneToMany
Species where no ortholog for WDR47 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR47 Gene

ENSEMBL:
Gene Tree for WDR47 (if available)
TreeFam:
Gene Tree for WDR47 (if available)

Paralogs for WDR47 Gene

Paralogs for WDR47 Gene

genes like me logo Genes that share paralogs with WDR47: view

Variants for WDR47 Gene

Sequence variations from dbSNP and Humsavar for WDR47 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1025996 -- 108,982,196(+) ATTGa(C/T)aattt intron-variant
rs10581443 -- 109,001,903(+) AAAAA(-/AGC)AGCAG intron-variant
rs10588434 -- 109,015,208(+) TAACA(-/ACA)GGTTC intron-variant
rs10596902 -- 109,015,204(+) AAAAT(-/AAC)AACAG intron-variant
rs10712683 -- 108,972,948(+) CTCAG(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR47 Gene

Variant ID Type Subtype PubMed ID
dgv490n54 CNV loss 21841781
dgv491n54 CNV gain 21841781
dgv492n54 CNV loss 21841781
dgv493n54 CNV gain+loss 21841781
dgv494n54 CNV loss 21841781
dgv495n54 CNV loss 21841781
dgv60e199 CNV deletion 23128226
dgv64n67 CNV loss 20364138
esv2658750 CNV deletion 23128226
esv2676133 CNV deletion 23128226
esv27754 CNV loss 19812545
esv2798 CNV loss 18987735
esv32817 CNV loss 17666407
esv3567248 CNV deletion 23714750
esv3587144 CNV loss 21293372
esv3587145 CNV loss 21293372
nsv1137794 CNV deletion 24896259
nsv437236 CNV loss 16327808
nsv547425 CNV gain 21841781
nsv547426 CNV loss 21841781
nsv547427 CNV loss 21841781
nsv547428 CNV loss 21841781
nsv547433 CNV gain+loss 21841781
nsv547440 CNV gain+loss 21841781
nsv547460 CNV loss 21841781
nsv547466 CNV gain 21841781
nsv547467 CNV loss 21841781
nsv823954 CNV loss 20364138
nsv823987 CNV loss 20364138
nsv831026 CNV loss 17160897
nsv946127 CNV duplication 23825009
nsv946128 CNV duplication 23825009
nsv956243 CNV deletion 24416366

Variation tolerance for WDR47 Gene

Residual Variation Intolerance Score: 6.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR47 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR47 Gene

Disorders for WDR47 Gene

Relevant External Links for WDR47

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR47

No disorders were found for WDR47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR47 Gene

Publications for WDR47 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for WDR47 Gene

Sources for WDR47 Gene

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