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Aliases for WDR47 Gene

Aliases for WDR47 Gene

  • WD Repeat Domain 47 2 3 5
  • Neuronal Enriched MAP-Interacting Protein 3 4
  • Nemitin 3 4
  • Neuronal Enriched MAP Interacting Protein 3
  • KIAA0893 4

External Ids for WDR47 Gene

Previous GeneCards Identifiers for WDR47 Gene

  • GC01M109225
  • GC01M109314
  • GC01M109512
  • GC01M107405

Summaries for WDR47 Gene

GeneCards Summary for WDR47 Gene

WDR47 (WD Repeat Domain 47) is a Protein Coding gene. An important paralog of this gene is GNB4.

Gene Wiki entry for WDR47 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR47 Gene

Genomics for WDR47 Gene

Regulatory Elements for WDR47 Gene

Promoters for WDR47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR47 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR47 Gene

Chromosome:
1
Start:
108,970,211 bp from pter
End:
109,042,228 bp from pter
Size:
72,018 bases
Orientation:
Minus strand

Genomic View for WDR47 Gene

Genes around WDR47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR47 Gene

Proteins for WDR47 Gene

  • Protein details for WDR47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94967-WDR47_HUMAN
    Recommended name:
    WD repeat-containing protein 47
    Protein Accession:
    O94967
    Secondary Accessions:
    • A8MX09
    • Q5TYV7
    • Q5TYV8
    • Q5TYV9
    • Q8IXT7
    • Q8IYU9

    Protein attributes for WDR47 Gene

    Size:
    919 amino acids
    Molecular mass:
    101949 Da
    Quaternary structure:
    • Interacts with MAP1S (via WD repeats).
    SequenceCaution:
    • Sequence=AK225781; Type=Frameshift; Positions=416; Evidence={ECO:0000305}; Sequence=BAA74916.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR47 Gene

Proteomics data for WDR47 Gene at MOPED

Post-translational modifications for WDR47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for WDR47 Gene

Domains & Families for WDR47 Gene

Gene Families for WDR47 Gene

Suggested Antigen Peptide Sequences for WDR47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94967

UniProtKB/Swiss-Prot:

WDR47_HUMAN :
  • Contains 1 CTLH domain.
  • Contains 7 WD repeats.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR47: view

Function for WDR47 Gene

genes like me logo Genes that share phenotypes with WDR47: view

Animal Models for WDR47 Gene

MGI Knock Outs for WDR47:

Animal Model Products

miRNA for WDR47 Gene

miRTarBase miRNAs that target WDR47

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR47 Gene

Localization for WDR47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR47 Gene

Cytoplasm, cytoskeleton. Note=Localization along microtubules is mediated by MAP1S. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR47 Gene COMPARTMENTS Subcellular localization image for WDR47 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for WDR47 Gene

Pathways & Interactions for WDR47 Gene

SuperPathways for WDR47 Gene

No Data Available

Interacting Proteins for WDR47 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383599%0d%0a9606.ENSP00000385036%0d%0a
Selected Interacting proteins: O94967-WDR47_HUMAN ENSP00000383599 for WDR47 Gene via I2D STRING MINT UniProtKB

Gene Ontology (GO) - Biological Process for WDR47 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR47 Gene

Drugs & Compounds for WDR47 Gene

No Compound Related Data Available

Transcripts for WDR47 Gene

Unigene Clusters for WDR47 Gene

WD repeat domain 47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR47 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for WDR47 Gene

GeneLoc Exon Structure for
WDR47
ECgene alternative splicing isoforms for
WDR47

Expression for WDR47 Gene

mRNA expression in normal human tissues for WDR47 Gene

mRNA differential expression in normal tissues according to GTEx for WDR47 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for WDR47 Gene

This gene is overexpressed in Fetal Brain (30.0), Frontal cortex (20.2), and Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR47 Gene



SOURCE GeneReport for Unigene cluster for WDR47 Gene Hs.570055

genes like me logo Genes that share expression patterns with WDR47: view

Protein tissue co-expression partners for WDR47 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for WDR47 Gene

Orthologs for WDR47 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR47 35
  • 99.82 (n)
  • 99.89 (a)
WDR47 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR47 36
  • 96 (a)
OneToOne
WDR47 35
  • 94.2 (n)
  • 97.17 (a)
dog
(Canis familiaris)
Mammalia WDR47 35
  • 94.35 (n)
  • 97.17 (a)
WDR47 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr47 16
Wdr47 36
  • 96 (a)
OneToOne
Wdr47 35
  • 90.22 (n)
  • 95.54 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR47 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR47 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr47 35
  • 89.24 (n)
  • 95.54 (a)
chicken
(Gallus gallus)
Aves WDR47 36
  • 91 (a)
OneToOne
WDR47 35
  • 81.77 (n)
  • 91.27 (a)
lizard
(Anolis carolinensis)
Reptilia WDR47 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr47 35
  • 71.93 (n)
  • 82.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14134 35
zebrafish
(Danio rerio)
Actinopterygii wdr47a 36
  • 78 (a)
OneToMany
wdr47b 36
  • 71 (a)
OneToMany
wdr47a 35
  • 68.61 (n)
  • 79.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006113 35
  • 55.08 (n)
  • 59.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2812 36
  • 51 (a)
OneToOne
CG2812 35
  • 54.05 (n)
  • 53.23 (a)
worm
(Caenorhabditis elegans)
Secernentea nmtn-1 35
  • 52.24 (n)
  • 45.61 (a)
nmtn-1 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE4 36
  • 20 (a)
OneToMany
Species with no ortholog for WDR47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR47 Gene

ENSEMBL:
Gene Tree for WDR47 (if available)
TreeFam:
Gene Tree for WDR47 (if available)

Paralogs for WDR47 Gene

Paralogs for WDR47 Gene

genes like me logo Genes that share paralogs with WDR47: view

Variants for WDR47 Gene

Sequence variations from dbSNP and Humsavar for WDR47 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs170896 -- 109,042,258(+) gggcg(G/T)ggagg upstream-variant-2KB
rs337294 -- 109,012,650(+) ATGGA(A/C)GCTTA intron-variant
rs337295 -- 108,997,629(+) gtggt(A/G)ggcgc intron-variant
rs337296 -- 108,992,318(-) TGATT(C/T)CGTGG intron-variant
rs337297 -- 109,002,604(-) AGTCT(A/G)TTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR47 Gene

Variant ID Type Subtype PubMed ID
nsv831026 CNV Loss 17160897
nsv437236 CNV Loss 16327808
esv32817 CNV Loss 17666407
esv2676133 CNV Deletion 23128226
nsv823954 CNV Loss 20364138
dgv64n67 CNV Loss 20364138
nsv823987 CNV Loss 20364138
esv2798 CNV Deletion 18987735
dgv60e199 CNV Deletion 23128226
esv27754 CNV Loss 19812545
esv2658750 CNV Deletion 23128226

Variation tolerance for WDR47 Gene

Residual Variation Intolerance Score: 6.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR47 Gene

HapMap Linkage Disequilibrium report
WDR47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR47 Gene

Disorders for WDR47 Gene

Relevant External Links for WDR47

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR47

No disorders were found for WDR47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR47 Gene

Publications for WDR47 Gene

  1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats. (PMID: 22523538) Wang W. … Yang Y. (PLoS ONE 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for WDR47 Gene

Sources for WDR47 Gene

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