WDR47 Gene
protein-coding GIFtS: 50
GCID: GC01M109512
|
|
WD repeat domain 47
| |
Aliases
for WDR47 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 471 2 | | KIAA08931 3 | | Neuronal Enriched MAP Interacting Protein2 3 | | Nemitin3 | | WD Repeat-Containing Protein 472 | | Nemitin3 |
Export aliases for WDR47 gene to outside databasesPrevious GC identifers: GC01M109225 GC01M109314 GC01M107405 |
Summaries
for WDR47 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for WDR47
|
Genomic Views
for WDR47 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR47 gene promoter:
HFH-3 AML1a MEF-2 FOXI1 MEF-2A NF-AT4 NF-AT2 SEF-1 (1) NF-AT3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR47
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR47 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3WDR47 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M109512: view genomic region
(about GC identifiers)
Start:
|
109,512,836 bp from pter |
End:
|
109,584,850 bp from pter |
Size:
|
72,015 bases |
Orientation:
|
minus strand |
|
Proteins
for WDR47 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR47_HUMAN, O94967 (See
protein sequence)Recommended Name: WD repeat-containing protein 47 Size: 919 amino acids; 101949 Da
Subunit: Interacts with MAP1S (via WD repeats) (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Note=Localization along microtubules is mediated byMAP1S (By similarity)
Sequence caution: Sequence=BAA74916.2; Type=Erroneous initiation;
Secondary accessions: Q5TYV7 Q5TYV8 Q5TYV9 Q8IXT7 Q8IYU9Alternative splicing: 3 isoforms: O94967-1 O94967-2 O94967-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR47: NX_O94967
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O94967
WDR47 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001136022.1 NP_001136023.1 NP_055784.3
ENSEMBL proteins: ENSP00000383599 ENSP00000358979 ENSP00000354339 ENSP00000358982 ENSP00000434289 ENSP00000437171 ENSP00000434868 ENSP00000433452 ENSP00000350301
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
WDR47 for ontologies About GeneDecksing
WDR47 Antibody Products:
Assay Products for WDR47: |
Protein
Domains /
Families
for WDR47 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR47 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O94967ProtoNet protein and cluster: O94967 2 Blocks protein families: IPB006594 Lissencephaly type-1-like homology motif IPB006595 CTLH
UniProtKB/Swiss-Prot: WDR47_HUMAN, O94967Similarity: Contains 1 CTLH domainSimilarity: Contains 1 LisH domainSimilarity: Contains 7 WD repeats |
Function
for WDR47 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR47 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR47 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 3): WDR47 (NM_001142550) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR47 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR47 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR47 |
1 GenomeRNAi human phenotype for WDR47:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Wdr47):
WDR47 for phenotypes About GeneDecksing
|
Pathways & Interactions
for WDR47 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR47
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/6 Interacting proteins for WDR47 (O949672, 3 ENSP000003835994) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- |
WDR47 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR47 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR47
Search CenterWatch for drugs/clinical trials and news about WDR47
|
Transcripts
for WDR47 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR47 gene (3 alternative transcripts): NM_001142550.1 NM_001142551.1 NM_014969.5 Unigene Cluster for WDR47: WD repeat domain 47 Hs.570055 [show with all ESTs]Unigene Representative Sequence: NM_0011425509 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000400794(uc010ovf.2) ENST00000369962 ENST00000361054 ENST00000369965
ENST00000530772 ENST00000529074 ENST00000531337 ENST00000528747 ENST00000357672(uc001dwl.3 uc001dwi.3 uc001dwj.3 uc001dwk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR47 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR47 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): WDR47 (NM_001142550) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR47 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR47 |
Additional cDNA sequence: AB020700.1 AK074616.1 AK225781.1 AK289789.1 AK294998.1 BC034964.2 BC039254.1 6 DOTS entries: DT.415043 DT.121422582 DT.100818546 DT.100891763 DT.121422576 DT.95161071 24/125 AceView cDNA sequences (see all 125): CB307001 Z38784 BQ721460 BE047974 CD679193 BE645046 CB306945 Z42608 BU623520 AL079452 BQ876458 AI889676 AW474586 AK074616 CA868444 AA813986 AA059407 BM661580 BM793705 CB321680 AU279918 AB020700 BM672481 T09148
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR47 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for WDR47
|
Expression
for WDR47 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR47 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAATTTAAA
About this image
See WDR47 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR47
SOURCE GeneReport for Unigene cluster: Hs.570055
SABiosciences Custom PCR Arrays for WDR47
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR47
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR47 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR47 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR47 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR47 |
Orthologs
for WDR47 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR47 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for WDR47 (if available)
TreeFam Gene Tree for WDR47 (if available) |
Paralogs
for WDR47 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR47 gene
- GNB22 GNB32 GNB12 GNB52 GNB42
2 SIMAP similar genes for WDR47 using alignment to 6 protein entries: WDR47_HUMAN (see all proteins):POC1B GNB5
WDR47 for paralogs About GeneDecksing
|
Genomic Variants
for WDR47 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR47 (109512836 - 109584850 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for WDR47
6 CNVs: 64574 43417 4241 74632 6773 84462
1 Indel: 74633 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR47 |
|
Disorders
/ Diseases
for WDR47 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR47 for disorders About GeneDecksing
2  diseases for WDR47: About MalaCardslissencephaly neuronitis
Export disorders for WDR47 gene to outside databases
|
Publications
for WDR47 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR47 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with WDR47) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats. (PubMed id 22523538)1 Wang W.... Yang Y. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
|
External Searches for WDR47 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR47 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR47 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WDR47 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR47 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR47 gene:
Search GeneIP for patents involving WDR47
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR47 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR47 |
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