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Aliases & Descriptions for WDR46
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BING4 1, 2, 3 | | C6orf11 2, 3 | | FP221 2 | | OTTHUMP00000029279 2 |
| | | Descriptions |
|---|
| WD repeat domain 46 2 | | WD repeat-containing protein BING4 3 | | chromosome 6 open reading frame 11 1 |
|
| | Search outside databases for aliases for WDR46 genePrevious GC identifer: GC06Mc33315 |
Summaries for WDR46(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for WDR46 |
Genomic Location for WDR46
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WDR46 gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3WDR46 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033355:
(about GC identifiers)
Start:
|
33,354,863 bp from pter |
End:
|
33,364,969 bp from pter |
Size:
|
10,107 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113897.1
| Proteins for WDR46
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213 (See
protein sequence)Recommended Name: WD repeat-containing protein 46 Size: 610 amino acids; 68041 Da
Secondary accessions: A6NDP5 Q5HYZ0 Q5STK5 Q5STR3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005443.2 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: WDR46 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | About this table
Antibodies for WDR46: Assays for WDR46: | Protein
Domains/ Families for WDR46(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15213
ProtoNet protein and cluster: O15213 1 Blocks protein family: IPB012952 BING4
UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213Similarity: Contains 6 WD repeats | Gene Function for WDR46
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005452
Applied Biosystems Silencer® siRNAs for WDR46
Sigma-Aldrich siRNA for WDR46  Sigma-Aldrich shRNA for WDR46  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005452                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005452                                  untagged cDNA clone in CMV expression vector: NM_005452 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005452
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | About this table | Pathways & Interactions for WDR46
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | About this table
|
Drugs & Compounds for WDR46(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WDR46
|
Transcripts for WDR46(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005452
Sigma-Aldrich siRNA for WDR46  Sigma-Aldrich shRNA for WDR46  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005452 REFSEQ mRNAs for WDR46 gene: NM_005452.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005452               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005452                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005452                                  untagged cDNA clone in CMV expression vector: NM_005452  Additional cDNA sequence: AF447870.1 AK292171.1 AK292616.1 AK297925.1 AK298151.1 AK308534.1 AK311388.1 AK315616.1 BC000388.2 CR597118.1 CR604572.1 CR615634.1 CR621799.1 21 DOTS entries: DT.214300 DT.100822238 DT.100822237 DT.100822221 DT.121364774 DT.100770860 DT.92457212 DT.95253275 DT.121364635 DT.100822225 DT.100841651 DT.121364785 DT.121364791 DT.100662443 DT.100822223 DT.121364685 DT.98083365 DT.100030751 DT.100836115 DT.100838589 DT.121364744 24/447 AceView cDNA sequences (see all 447
):AW136512 AI610795 AL557009 AI745013 BX951566 NM_005452 CR597118 BM851796 AL526244 CA310883 CB161305 F06119 BQ954602 BG119460 AW250879 BG283791 BX283822 BC000388 BE502046 BX353559 AL527887 CA416809 AI866952 AI654441
highest scoring ESTs for WDR46:AL513998 AL518384 AL526244 AL527887 AL552140 AL555415 AL559814 AL579741 AL583014 AL703269 Unigene Cluster for WDR46: WD repeat domain 46 Hs.520063 [show with all ESTs]Unigene Representative Sequence: AK292171
GeneLoc Exon Structure
|
Expression for WDR46
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WDR46 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WDR46
1 / 2 / 3 3 probe-sets matching WDR46 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GATGAGGAAC
SOURCE GeneReport for Unigene cluster: Hs.520063
|
Orthologs for WDR46
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDR46 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for WDR46 | Paralogs for WDR46(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for WDR46(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WDR46 (up to first 250kb)
|
Disorders & Mutations for WDR46
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611440
|
Medical News for WDR46(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WDR46 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for WDR46 gene (see all 11
):- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)2, 3, 4 Herberg J.A.... Trowsdale J. (1998)
- Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)3, 4 Nousiainen M.... Koerner R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)3, 4 Wan D....Gu J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. (PubMed id 9521053)2, 3 Herberg J.A....Trowsdale J. (1998)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Nucleolar proteome dynamics. (PubMed id 15635413)3 Andersen J.S....Mann M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for WDR46
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR46
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WDR46
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR46(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WDR46(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WDR46:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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