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Aliases for WDR46 Gene

Aliases for WDR46 Gene

  • WD Repeat Domain 46 2 3
  • WD Repeat-Containing Protein BING4 3 4
  • C6orf11 3 4
  • BING4 3 4
  • Chromosome 6 Open Reading Frame 11 2
  • WD Repeat-Containing Protein 46 3
  • FP221 3
  • UTP7 3

External Ids for WDR46 Gene

Previous Symbols for WDR46 Gene

  • C6orf11

Summaries for WDR46 Gene

GeneCards Summary for WDR46 Gene

WDR46 (WD Repeat Domain 46) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR46 Gene

  • Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Gene Wiki entry for WDR46 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR46 Gene

Genomics for WDR46 Gene

Genomic Location for WDR46 Gene

Start:
33,278,905 bp from pter
End:
33,289,527 bp from pter
Size:
10,623 bases
Orientation:
Minus strand

Genomic View for WDR46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for WDR46 Gene

Proteins for WDR46 Gene

  • Protein details for WDR46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15213-WDR46_HUMAN
    Recommended name:
    WD repeat-containing protein 46
    Protein Accession:
    O15213
    Secondary Accessions:
    • A6NDP5
    • Q5HYZ0
    • Q5STK5
    • Q5STR3

    Protein attributes for WDR46 Gene

    Size:
    610 amino acids
    Molecular mass:
    68071 Da
    Quaternary structure:
    • Interacts with DDX21, NCL, NOP2 and EBNA1BP2.

neXtProt entry for WDR46 Gene

Proteomics data for WDR46 Gene at MOPED

Post-translational modifications for WDR46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR46 Gene

Domains for WDR46 Gene

Gene Families for WDR46 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for WDR46 Gene

UniProtKB/Swiss-Prot:

WDR46_HUMAN
Similarity:
  • Contains 6 WD repeats.:
    • O15213
genes like me logo Genes that share domains with WDR46: view

Function for WDR46 Gene

Molecular function for WDR46 Gene

UniProtKB/Swiss-Prot Function: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Gene Ontology (GO) - Molecular Function for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR46: view
genes like me logo Genes that share phenotypes with WDR46: view

miRNA for WDR46 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR46 Gene

Localization for WDR46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR46 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR46 Gene COMPARTMENTS Subcellular localization image for WDR46 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005730 nucleolus IBA --
GO:0030686 90S preribosome IBA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with WDR46: view

Pathways for WDR46 Gene

SuperPathways for WDR46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0008150 biological_process ND --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with WDR46: view

No data available for Pathways by source for WDR46 Gene

Transcripts for WDR46 Gene

Unigene Clusters for WDR46 Gene

WD repeat domain 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR46 Gene

No ASD Table

Relevant External Links for WDR46 Gene

GeneLoc Exon Structure for
WDR46
ECgene alternative splicing isoforms for
WDR46

Expression for WDR46 Gene

mRNA expression in normal human tissues for WDR46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR46 Gene

SOURCE GeneReport for Unigene cluster for WDR46 Gene Hs.520063

genes like me logo Genes that share expressions with WDR46: view

Orthologs for WDR46 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR46 36
  • 99.73 (n)
  • 99.34 (a)
WDR46 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6ORF11 37
  • 89 (a)
OneToOne
WDR46 36
  • 87.03 (n)
  • 89.07 (a)
dog
(Canis familiaris)
Mammalia WDR46 36
  • 86.45 (n)
  • 86.72 (a)
WDR46 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr46 36
  • 83.5 (n)
  • 85.53 (a)
Wdr46 16
Wdr46 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR46 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr46 36
  • 84.68 (n)
  • 86.82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7166 36
wdr46 36
  • 56.78 (n)
  • 55.32 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr46 36
  • 58.29 (n)
  • 55.97 (a)
wdr46 37
  • 51 (a)
OneToMany
wdr46 37
  • 35 (a)
OneToMany
zgc63793 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004190 36
  • 53.67 (n)
  • 47.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2260 36
  • 52.35 (n)
  • 45.33 (a)
CG2260 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wdr-46 36
  • 52.78 (n)
  • 48.71 (a)
wdr-46 37
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL034W 36
  • 50.52 (n)
  • 44.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP7 36
  • 47.1 (n)
  • 44.02 (a)
UTP7 37
  • 37 (a)
OneToOne
UTP7 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09262g 36
  • 50.98 (n)
  • 46.62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10530 36
  • 48.54 (n)
  • 39.24 (a)
rice
(Oryza sativa)
Liliopsida Os01g0183100 36
  • 49.44 (n)
  • 43.34 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01502 36
  • 51.23 (n)
  • 43.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC959.03c 36
  • 48.63 (n)
  • 43.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 44 (a)
OneToOne
Species with no ortholog for WDR46:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR46 Gene

ENSEMBL:
Gene Tree for WDR46 (if available)
TreeFam:
Gene Tree for WDR46 (if available)

Paralogs for WDR46 Gene

No data available for Paralogs for WDR46 Gene

Variants for WDR46 Gene

Sequence variations from dbSNP and Humsavar for WDR46 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2475 -- 33,279,330(+) GNCTT(C/T)GCCTC synonymous-codon, reference, missense
rs120626 -- 33,280,098(-) TCAGG(A/T)TCCCC intron-variant
rs213215 -- 33,280,397(-) GAGAT(C/T)CCCCC intron-variant
rs363958 -- 33,280,314(-) CCCCC(C/G)TGCTG intron-variant
rs363959 -- 33,280,300(-) AAGGT(A/C/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR46 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897
esv2731890 CNV Deletion 23290073
esv29761 CNV Loss 19812545

Relevant External Links for WDR46 Gene

HapMap Linkage Disequilibrium report
WDR46

Disorders for WDR46 Gene

Relevant External Links for WDR46

Genetic Association Database (GAD)
WDR46
Human Genome Epidemiology (HuGE) Navigator
WDR46
genes like me logo Genes that share disorders with WDR46: view

No data available for UniProtKB/Swiss-Prot for WDR46 Gene

Publications for WDR46 Gene

  1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 49

Products for WDR46 Gene

Sources for WDR46 Gene

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