WDR46 Gene
protein-coding GIFtS: 48
GCID: GC06M033246
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WD repeat domain 46(Previous name: chromosome 6 open reading frame 11 )
(Previous symbol: C6orf11)
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Aliases
for WDR46 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 461 2 | | WD Repeat-Containing Protein BING42 3 | | BING41 2 3 | | Chromosome 6 Open Reading Frame 111 | | C6orf111 2 3 | | FP2212 | | UTP71 2 | | WD Repeat-Containing Protein 462 |
Export aliases for WDR46 gene to outside databasesPrevious GC identifers: GC06M033355 GC06Mc33315 GC06M032988 |
Summaries
for WDR46 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for WDR46
|
Genomic Views
for WDR46 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1 NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR46 gene promoter:
Sp1 p53 AP-1 ATF-2 Olf-1 HNF-4alpha2 CUTL1 HNF-4alpha1 YY1 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR46
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR46 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3WDR46 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033246: view genomic region
(about GC identifiers)
Start:
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33,246,880 bp from pter |
End:
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33,257,304 bp from pter |
Size:
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10,425 bases |
Orientation:
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minus strand |
4 alternative locations:
| Chr6-,ALT_REF_LOCI_3 33,224,810-33,246,271 | Chr6-,ALT_REF_LOCI_2 33,168,491-33,218,102 | Chr6-,ALT_REF_LOCI_5 33,332,077-33,342,471 | | Chr6-,ALT_REF_LOCI_6 33,175,727-33,221,731 |
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Proteins
for WDR46 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213 (See
protein sequence)Recommended Name: WD repeat-containing protein 46 Size: 610 amino acids; 68071 Da
Secondary accessions: A6NDP5 Q5HYZ0 Q5STK5 Q5STR3Explore the universe of human proteins at neXtProt for WDR46: NX_O15213
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15213
WDR46 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157739.1 NP_005443.3
ENSEMBL proteins: ENSP00000363746 ENSP00000405568
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
WDR46 for ontologies About GeneDecksing
WDR46 Antibody Products:
Assay Products for WDR46: |
Protein
Domains /
Families
for WDR46 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR46 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15213ProtoNet protein and cluster: O15213 1 Blocks protein family: IPB012952 BING4
UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213Similarity: Contains 6 WD repeats |
Function
for WDR46 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): WDR46 (NM_001164267) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR46 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR46 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR46 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
WDR46 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for WDR46:
|
Pathways & Interactions
for WDR46 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR46
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/112 Interacting proteins for WDR46 (O152133 ENSP000003637464) via UniProtKB, MINT, STRING, and/or I2D (see all 112)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
WDR46 for ontologies About GeneDecksing
|
Drugs & Compounds
for WDR46 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR46
Search CenterWatch for drugs/clinical trials and news about WDR46
|
Transcripts
for WDR46 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR46 gene (2 alternative transcripts): NM_001164267.1 NM_005452.5 Unigene Cluster for WDR46: WD repeat domain 46 Hs.520063 [show with all ESTs]Unigene Representative Sequence: NM_00545210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467874 ENST00000473611 ENST00000461951 ENST00000374617(uc011dra.2 uc003ods.3 uc010juo.1)
ENST00000489905 ENST00000444176 ENST00000488944 ENST00000477718 ENST00000468157
ENST00000481025
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): WDR46 (NM_001164267) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR46 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR46 |
Additional cDNA sequence: AF447870.1 AK292171.1 AK292616.1 AK297925.1 AK298151.1 AK308534.1 AK311388.1 AK315616.1 BC000388.2 21 DOTS entries: DT.214300 DT.100822238 DT.100822237 DT.100822221 DT.121364774 DT.92457212 DT.100770860 DT.95253275 DT.121364635 DT.100822225 DT.100841651 DT.121364785 DT.121364791 DT.100662443 DT.100822223 DT.121364685 DT.98083365 DT.100030751 DT.100836115 DT.100838589 DT.121364744 24/447 AceView cDNA sequences (see all 447): BM851796 CA416809 BX951566 CR597118 AL527887 AA776348 AI610795 AI421287 AL579741 CR615634 BX332248 BX353559 AL526244 BG250391 CB161305 BE502046 NM_005452 BG283791 F06119 BQ954602 BM810952 BU633065 BX283822 BC000388
GeneLoc Exon Structure
|
Expression
for WDR46 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR46 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAGGAAC
About this image
See WDR46 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR46
SOURCE GeneReport for Unigene cluster: Hs.520063
SABiosciences Custom PCR Arrays for WDR46
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR46
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR46 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR46 |
Orthologs
for WDR46 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR46 gene from 8/30 species (see all 30) About this table
ENSEMBL Gene Tree for WDR46 (if available)
TreeFam Gene Tree for WDR46 (if available) |
Paralogs
for WDR46 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR46 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR46 (33246880 - 33257304 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for WDR46
1 CNV: 64478 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR46 |
|
Disorders
/ Diseases
for WDR46 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
WDR46 for disorders About GeneDecksing
OMIM gene information: 611440
OMIM disorders: --
3  diseases for WDR46: About MalaCardssystemic lupus erythematosus lupus erythematosus malaria
Human Genome Epidemiology (HuGE) Navigator: WDR46 (2 documents)
Export disorders for WDR46 gene to outside databases
|
Publications
for WDR46 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR46 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with WDR46) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)1, 2, 3 Herberg J.A.... Trowsdale J. (1998)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. (PubMed id 9521053)1, 3 Herberg J.A.... Trowsdale J. (1998)
- WDR46 is a Genetic Risk Factor for Aspirin-Exacerbated Respiratory Disease in a Korean Population. (PubMed id 22754713)1 Pasaje C.F....Shin H.D. (2012)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
|
External Searches for WDR46 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR46 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR46 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR46 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR46 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR46 gene:
Search GeneIP for patents involving WDR46
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR46 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR46 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR46 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR46 | | | OriGene Protein Over-expression Lysate for WDR46 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR46 | | OriGene 3'-UTR Clone for WDR46 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR46 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WDR46 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for WDR46 |
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 | | | WDR46 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR46 |
|  |  |  | | | | ThermoFisher Antibody for WDR46 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR46 |
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