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WDR46 Gene

protein-coding GIFtS: 46

GC06M033355

WD repeat domain 46
(Previous name: chromosome 6 open reading frame 11 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C6orf11)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BING4 ^¹, ², ³
C6orf11 ^², ³
FP221 ^²
OTTHUMP00000029279 ^²

Descriptions
WD repeat domain 46 ^²
WD repeat-containing protein BING4 ^³
chromosome 6 open reading frame 11 ^¹

External Ids
HGNC: 13923¹
Entrez Gene: 9277²
UniProtKB: O15213³

Search outside databases for aliases for WDR46 gene

Previous GC identifer: GC06Mc33315

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for WDR46

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR46 gene

Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3

WDR46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M033355: (about GC identifiers)

Start:	33,354,863 bp from pter
End:	33,364,969 bp from pter
Size:	10,107 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113897.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213 (See protein sequence)

Recommended Name: WD repeat-containing protein 46

Size: 610 amino acids; 68041 Da

Secondary accessions: A6NDP5 Q5HYZ0 Q5STK5 Q5STR3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005443.2
Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WDR46)
	Human Recombinant Proteins from Abnova (WDR46)

OriGene Purified Recombinant Human Protein: WDR46

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for WDR46:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (WDR46), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for WDR46

Assays for WDR46:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15213

ProtoNet protein and cluster: O15213

1 Blocks protein family: IPB012952 BING4

UniProtKB/Swiss-Prot: WDR46_HUMAN, O15213

Similarity: Contains 6 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR46)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005452

Applied Biosystems Silencer® siRNAs for WDR46

Sigma-Aldrich siRNA for WDR46

Sigma-Aldrich shRNA for WDR46

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR46
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005452
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005452
untagged cDNA clone in CMV expression vector: NM_005452

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005452

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR46

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR46)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005452

Sigma-Aldrich siRNA for WDR46

Sigma-Aldrich shRNA for WDR46

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005452

REFSEQ mRNAs for WDR46 gene:

NM_005452.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005452

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005452
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005452
                                 untagged cDNA clone in CMV expression vector: NM_005452

Additional cDNA sequence:

AF447870.1 AK292171.1 AK292616.1 AK297925.1 AK298151.1 AK308534.1 AK311388.1 AK315616.1

BC000388.2 CR597118.1 CR604572.1 CR615634.1 CR621799.1

21 DOTS entries:

DT.214300 DT.100822238 DT.100822237 DT.100822221 DT.121364774 DT.100770860 DT.92457212 DT.95253275

DT.121364635 DT.100822225 DT.100841651 DT.121364785 DT.121364791 DT.100662443 DT.100822223 DT.121364685

DT.98083365 DT.100030751 DT.100836115 DT.100838589 DT.121364744

24/447 AceView cDNA sequences (see all 447 ):

AW136512 AI610795 AL557009 AI745013 BX951566 NM_005452 CR597118 BM851796

AL526244 CA310883 CB161305 F06119 BQ954602 BG119460 AW250879 BG283791

BX283822 BC000388 BE502046 BX353559 AL527887 CA416809 AI866952 AI654441

highest scoring ESTs for WDR46:

AL513998 AL518384 AL526244 AL527887 AL552140 AL555415 AL559814 AL579741 AL583014 AL703269

Unigene Cluster for WDR46:

WD repeat domain 46

Hs.520063 [show with all ESTs]

Unigene Representative Sequence: AK292171

GeneLoc Exon Structure

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR46 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR46

¹ / ² / ³

3 probe-sets matching WDR46 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33250_at²^{, 3}	U95-A	3	1.00	0.33	1.00	1.00	AL031228	0.20	0.08	0.15	1
209196_at²^{, 3}	U133-A	3	1.00	0.33	--	--	BC000388	0.80	1.00	0.91	1
209196_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GATGAGGAAC

SOURCE GeneReport for Unigene cluster: Hs.520063

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR46 gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR46¹	--	WD repeat domain 46	84.98(n) 85.43(a)	481738 XM_538859.2 XP_538859.2
chimpanzee (Pan troglodytes)	WDR46¹	--	WD repeat domain 46	99.78(n) 99.51(a)	462610 XM_518401.2 XP_518401.2
cow (Bos taurus)	WDR46¹	--	WD repeat domain 46	87.09(n) 89.24(a)	509913 NM_001015564.1 NP_001015564.1
rat (Rattus norvegicus)	Wdr46¹	--	WD repeat domain 46	84.73(n) 86.99(a)	309628 NM_212491.2 NP_997656.1
mouse (Mus musculus)	Wdr46^{1, 5}	17⁵	WD repeat domain 46^{1, 5}	83.55(n)¹ 85.69(a)¹	57315¹ NM_020603.2¹ NP_065628.1¹ AF100956⁵ AK009209⁵ (see all 14)

About this table Species with no ortholog for WDR46

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/61 NCBI SNPs in WDR46 are shown (see all 61 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs14398^1,2	C,F,H	33362643(+)	`AAGACA/GCAGTA`	1	V/A	mis¹		26		MN EU EA WA NS NA	4192
--	rs3185180^1,2	C	33355258(-)	`GAGGAA/CCACAG`	1	E/D	mis¹		0	--	--	--	--
	rs469064^1,2	A,C,F,H,O	33358454(-)	`CTTGAG/TGCTAA`	1	--	int¹		22		EA NA EU WA NS	1912
	rs446735^1,2	A,C,F,H	33363081(-)	`ACTGGT/GTGGAA`	1	--	int¹		15		EA EU WA NS NA	2820
	rs455567^1,2	A,C,F,H	33360093(-)	`GGAGAT/CAAAAG`	1	--	int¹		14		MN EU EA WA NS	1606
	rs6907034^1,2	A,F,H	33360639(+)	`acagcC/Tgagtg`	1	--	int¹		4		EU EA WA	404
	rs467508^1,2	C,F,H	33360314(-)	`gggagC/TgctGT`	1	--	int¹		3		EA WA	288
	rs465151^1,2	C,F,H	33363347(-)	`TCAGCG/AGTCAG`	1	--	int¹		9		MN EU EA WA	1022
--	rs9469395^1,2	F,H	33355961(+)	`ACCCCG/ATCCAG`	1	--	int¹		4		EU EA WA	418
	rs6906691^1,2	F,H	33360539(+)	`accgtA/Gtgaaa`	1	--	int¹		4		EU EA WA	414

About this table

HapMap Linkage Disequilibrium images for WDR46 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611440

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/11 PubMed articles for WDR46 gene (see all 11 ):

TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PubMed id 9545376)^{2, 3, 4} Herberg J.A.... Trowsdale J. (1998)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. (PubMed id 9521053)^{2, 3} Herberg J.A....Trowsdale J. (1998)
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)⁴ Cantin G.T....Yates J.R. III (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Nucleolar proteome dynamics. (PubMed id 15635413)³ Andersen J.S....Mann M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9277	HGNC: 13923	AceView: C6orf11	euGenes: HUgn9277	ECgene: WDR46
H-InvDB: WDR46

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR46
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for WDR46:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR46-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR46		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for WDR46		Browse small molecules at Sigma-Aldrich
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Search Tocris compounds for WDR46

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WDR46 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for WDR46

Summaries
for WDR46

Genomic Location
for WDR46

Proteins
for WDR46

Protein Domains/
Families
for WDR46

Gene Function
for WDR46

Pathways & Interactions
for WDR46

Drugs & Compounds
for WDR46

Transcripts
for WDR46

Expression
for WDR46

Orthologs
for WDR46

Paralogs
for WDR46

SNPs/Variants
for WDR46

Disorders & Mutations
for WDR46

Medical News
for WDR46

Publications
for WDR46

Search for WDR46

Genome Databases showing WDR46

Other Databases showing WDR46

Specialized Databases showing WDR46

Licensable Technologies
for WDR46

Services
for WDR46

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR46 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor WDR46

Summariesfor WDR46

Genomic Locationfor WDR46

Proteinsfor WDR46

Protein Domains/Familiesfor WDR46

Gene Functionfor WDR46

Pathways & Interactionsfor WDR46

Drugs & Compoundsfor WDR46

Transcriptsfor WDR46

Expression for WDR46

Orthologsfor WDR46

Paralogsfor WDR46

SNPs/Variantsfor WDR46

Disorders & Mutationsfor WDR46

Medical Newsfor WDR46

Publicationsfor WDR46

Search for WDR46

Genome Databases showing WDR46

Other Databases showing WDR46

Specialized Databases showing WDR46

Licensable Technologiesfor WDR46

Servicesfor WDR46

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR46

Summaries
for WDR46

Genomic Location
for WDR46

Proteins
for WDR46

Protein Domains/
Families
for WDR46

Gene Function
for WDR46

Pathways & Interactions
for WDR46

Drugs & Compounds
for WDR46

Transcripts
for WDR46

Expression
for WDR46

Orthologs
for WDR46

Paralogs
for WDR46

SNPs/Variants
for WDR46

Disorders & Mutations
for WDR46

Medical News
for WDR46

Publications
for WDR46

Licensable Technologies
for WDR46

Services
for WDR46