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Aliases for WDR46 Gene

Aliases for WDR46 Gene

  • WD Repeat Domain 46 2 3
  • WD Repeat-Containing Protein BING4 3 4
  • C6orf11 3 4
  • BING4 3 4
  • Chromosome 6 Open Reading Frame 11 2
  • WD Repeat-Containing Protein 46 3
  • FP221 3
  • UTP7 3

External Ids for WDR46 Gene

Previous HGNC Symbols for WDR46 Gene

  • C6orf11

Previous GeneCards Identifiers for WDR46 Gene

  • GC06M033355
  • GC06Mc33315
  • GC06M032988

Summaries for WDR46 Gene

GeneCards Summary for WDR46 Gene

WDR46 (WD Repeat Domain 46) is a Protein Coding gene.

UniProtKB/Swiss-Prot for WDR46 Gene

  • Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Gene Wiki entry for WDR46 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR46 Gene

Genomics for WDR46 Gene

Regulatory Elements for WDR46 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR46 Gene

33,278,905 bp from pter
33,289,527 bp from pter
10,623 bases
Minus strand

Genomic View for WDR46 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for WDR46 Gene

  • Protein details for WDR46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • A6NDP5
    • Q5HYZ0
    • Q5STK5
    • Q5STR3

    Protein attributes for WDR46 Gene

    610 amino acids
    Molecular mass:
    68071 Da
    Quaternary structure:
    • Interacts with DDX21, NCL, NOP2 and EBNA1BP2.

neXtProt entry for WDR46 Gene

Proteomics data for WDR46 Gene at MOPED

Post-translational modifications for WDR46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR46 Gene

Domains for WDR46 Gene

Gene Families for WDR46 Gene

  • WDR :WD repeat domain containing

Protein Domains for WDR46 Gene

Graphical View of Domain Structure for InterPro Entry



  • O15213
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR46: view

Function for WDR46 Gene

Molecular function for WDR46 Gene

UniProtKB/Swiss-Prot Function: Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Gene Ontology (GO) - Molecular Function for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR46: view
genes like me logo Genes that share phenotypes with WDR46: view

Animal Model Products

CRISPR Products

miRNA for WDR46 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR46 Gene

Localization for WDR46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR46 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for WDR46 Gene COMPARTMENTS Subcellular localization image for WDR46 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005730 nucleolus IBA --
GO:0030686 90S preribosome IBA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with WDR46: view

Pathways for WDR46 Gene

SuperPathways for WDR46 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0008150 biological_process ND --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with WDR46: view

No data available for Pathways by source for WDR46 Gene

Transcripts for WDR46 Gene

Unigene Clusters for WDR46 Gene

WD repeat domain 46:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR46

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR46 Gene

No ASD Table

Relevant External Links for WDR46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR46 Gene

mRNA expression in normal human tissues for WDR46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR46 Gene

SOURCE GeneReport for Unigene cluster for WDR46 Gene Hs.520063

genes like me logo Genes that share expressions with WDR46: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR46 Gene

Orthologs for WDR46 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR46 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR46 35
  • 99.73 (n)
  • 99.34 (a)
WDR46 36
  • 99 (a)
(Bos Taurus)
Mammalia C6ORF11 36
  • 89 (a)
WDR46 35
  • 87.03 (n)
  • 89.07 (a)
(Canis familiaris)
Mammalia WDR46 35
  • 86.45 (n)
  • 86.72 (a)
WDR46 36
  • 86 (a)
(Mus musculus)
Mammalia Wdr46 35
  • 83.5 (n)
  • 85.53 (a)
Wdr46 16
Wdr46 36
  • 83 (a)
(Monodelphis domestica)
Mammalia WDR46 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Wdr46 35
  • 84.68 (n)
  • 86.82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7166 35
wdr46 35
  • 56.78 (n)
  • 55.32 (a)
(Danio rerio)
Actinopterygii wdr46 35
  • 58.29 (n)
  • 55.97 (a)
wdr46 36
  • 51 (a)
wdr46 36
  • 35 (a)
zgc63793 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004190 35
  • 53.67 (n)
  • 47.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2260 35
  • 52.35 (n)
  • 45.33 (a)
CG2260 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea wdr-46 35
  • 52.78 (n)
  • 48.71 (a)
wdr-46 36
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL034W 35
  • 50.52 (n)
  • 44.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP7 35
  • 47.1 (n)
  • 44.02 (a)
UTP7 36
  • 37 (a)
UTP7 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09262g 35
  • 50.98 (n)
  • 46.62 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10530 35
  • 48.54 (n)
  • 39.24 (a)
(Oryza sativa)
Liliopsida Os01g0183100 35
  • 49.44 (n)
  • 43.34 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01502 35
  • 51.23 (n)
  • 43.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC959.03c 35
  • 48.63 (n)
  • 43.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for WDR46:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR46 Gene

Gene Tree for WDR46 (if available)
Gene Tree for WDR46 (if available)

Paralogs for WDR46 Gene

No data available for Paralogs for WDR46 Gene

Variants for WDR46 Gene

Sequence variations from dbSNP and Humsavar for WDR46 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2475 -- 33,279,330(+) GNCTT(C/T)GCCTC synonymous-codon, reference, missense
rs120626 -- 33,280,098(-) TCAGG(A/T)TCCCC intron-variant
rs213215 -- 33,280,397(-) GAGAT(C/T)CCCCC intron-variant
rs363958 -- 33,280,314(-) CCCCC(C/G)TGCTG intron-variant
rs363959 -- 33,280,300(-) AAGGT(A/C/G)AGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR46 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897
esv2731890 CNV Deletion 23290073
esv29761 CNV Loss 19812545

Relevant External Links for WDR46 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR46 Gene

Disorders for WDR46 Gene

Relevant External Links for WDR46

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with WDR46: view

No data available for UniProtKB/Swiss-Prot for WDR46 Gene

Publications for WDR46 Gene

  1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 48

Products for WDR46 Gene

Sources for WDR46 Gene

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