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Aliases for WDR46 Gene

Aliases for WDR46 Gene

  • WD Repeat Domain 46 2 3 5
  • WD Repeat-Containing Protein BING4 3 4
  • C6orf11 3 4
  • BING4 3 4
  • Chromosome 6 Open Reading Frame 11 2
  • FP221 3
  • UTP7 3

External Ids for WDR46 Gene

Previous HGNC Symbols for WDR46 Gene

  • C6orf11

Previous GeneCards Identifiers for WDR46 Gene

  • GC06M033355
  • GC06Mc33315
  • GC06M033246
  • GC06M032988

Summaries for WDR46 Gene

GeneCards Summary for WDR46 Gene

WDR46 (WD Repeat Domain 46) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for WDR46 Gene

  • Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.

Gene Wiki entry for WDR46 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR46 Gene

Genomics for WDR46 Gene

Regulatory Elements for WDR46 Gene

Enhancers for WDR46 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR46 on UCSC Golden Path with GeneCards custom track

Promoters for WDR46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR46 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR46 Gene

33,279,103 bp from pter
33,289,527 bp from pter
10,425 bases
Minus strand

Genomic View for WDR46 Gene

Genes around WDR46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for WDR46 Gene

  • Protein details for WDR46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • A6NDP5
    • Q5HYZ0
    • Q5STK5
    • Q5STR3

    Protein attributes for WDR46 Gene

    610 amino acids
    Molecular mass:
    68071 Da
    Quaternary structure:
    • Interacts with DDX21, NCL, NOP2 and EBNA1BP2.

neXtProt entry for WDR46 Gene

Proteomics data for WDR46 Gene at MOPED

Post-translational modifications for WDR46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR46 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR46 Gene

Domains & Families for WDR46 Gene

Gene Families for WDR46 Gene

Protein Domains for WDR46 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 WD repeats.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR46: view

Function for WDR46 Gene

Molecular function for WDR46 Gene

UniProtKB/Swiss-Prot Function:
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus.
genes like me logo Genes that share phenotypes with WDR46: view

Animal Model Products

miRNA for WDR46 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR46 Gene

Localization for WDR46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR46 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for WDR46 Gene COMPARTMENTS Subcellular localization image for WDR46 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
genes like me logo Genes that share ontologies with WDR46: view

Pathways & Interactions for WDR46 Gene

genes like me logo Genes that share pathways with WDR46: view

Pathways by source for WDR46 Gene

Gene Ontology (GO) - Biological Process for WDR46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with WDR46: view

No data available for SIGNOR curated interactions for WDR46 Gene

Drugs & Compounds for WDR46 Gene

No Compound Related Data Available

Transcripts for WDR46 Gene

Unigene Clusters for WDR46 Gene

WD repeat domain 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR46 Gene

No ASD Table

Relevant External Links for WDR46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR46 Gene

mRNA expression in normal human tissues for WDR46 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WDR46 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.7), Blymphocyte (9.1), CD8 Tcells (7.8), Pancreas (7.4), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR46 Gene

SOURCE GeneReport for Unigene cluster for WDR46 Gene Hs.520063

genes like me logo Genes that share expression patterns with WDR46: view

Protein tissue co-expression partners for WDR46 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR46 Gene

Orthologs for WDR46 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR46 35
  • 87.03 (n)
  • 89.07 (a)
C6ORF11 36
  • 89 (a)
(Canis familiaris)
Mammalia WDR46 35
  • 86.45 (n)
  • 86.72 (a)
WDR46 36
  • 86 (a)
(Mus musculus)
Mammalia Wdr46 35
  • 83.5 (n)
  • 85.53 (a)
Wdr46 16
Wdr46 36
  • 83 (a)
(Pan troglodytes)
Mammalia WDR46 35
  • 99.73 (n)
  • 99.34 (a)
WDR46 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr46 35
  • 84.68 (n)
  • 86.82 (a)
(Monodelphis domestica)
Mammalia WDR46 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7166 35
wdr46 35
  • 56.78 (n)
  • 55.32 (a)
(Danio rerio)
Actinopterygii wdr46 35
  • 58.29 (n)
  • 55.97 (a)
zgc63793 35
wdr46 36
  • 51 (a)
wdr46 36
  • 35 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004190 35
  • 53.67 (n)
  • 47.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2260 35
  • 52.35 (n)
  • 45.33 (a)
CG2260 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea wdr-46 35
  • 52.78 (n)
  • 48.71 (a)
wdr-46 36
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL034W 35
  • 50.52 (n)
  • 44.84 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09262g 35
  • 50.98 (n)
  • 46.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP7 35
  • 47.1 (n)
  • 44.02 (a)
UTP7 36
  • 37 (a)
UTP7 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G10530 35
  • 48.54 (n)
  • 39.24 (a)
(Oryza sativa)
Liliopsida Os01g0183100 35
  • 49.44 (n)
  • 43.34 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01502 35
  • 51.23 (n)
  • 43.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC959.03c 35
  • 48.63 (n)
  • 43.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for WDR46:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR46 Gene

Gene Tree for WDR46 (if available)
Gene Tree for WDR46 (if available)

Paralogs for WDR46 Gene

No data available for Paralogs for WDR46 Gene

Variants for WDR46 Gene

Sequence variations from dbSNP and Humsavar for WDR46 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_022025 -
VAR_053433 -
VAR_053434 -
rs1061736 -- 33,284,663(+) CTACT(A/G)CCCAT intron-variant
rs6906691 -- 33,284,784(+) accgt(A/G)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR46 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv5249 CNV Loss 18451855
nsv830635 CNV Loss 17160897
esv2731890 CNV Deletion 23290073
esv29761 CNV Loss 19812545

Variation tolerance for WDR46 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.34; 81.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR46 Gene

Disorders for WDR46 Gene

Relevant External Links for WDR46

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR46 Gene

Publications for WDR46 Gene

  1. TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. (PMID: 9545376) Herberg J.A. … Trowsdale J. (J. Mol. Biol. 1998) 2 3 4 67
  2. Dynamics of WD-repeat containing proteins in SSU processome components. (PMID: 24754225) Wada K. … Horigome T. (Biochem. Cell Biol. 2014) 2 3
  3. Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. (PMID: 9521053) Herberg J.A. … Trowsdale J. (Eur. J. Immunol. 1998) 2 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for WDR46 Gene

Sources for WDR46 Gene