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WDR45L Gene

protein-coding GIFtS: 41

GC17M078165

WDR45-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
WDR45-like ^²
WIPI-3 ^², ³
WIPI3 ^¹, ², ³

Descriptions
WD repeat domain phosphoinositide-interacting protein 3 ^²
WD repeat protein 45-like ^²
WD repeat-containing protein 45-like ^³
WDR45-like protein ^², ³
WIPI49-like protein ^², ³

External Ids
HGNC: 25072¹
Entrez Gene: 56270²
UniProtKB: Q5MNZ6³
Ensembl: ENSG00000141580⁷

Search outside databases for aliases for WDR45L gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR45L:

This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The

protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that

mediates protein-protein interactions, and a conserved motif for interaction with phospholipids.

The human genome contains several pseudogenes of this gene. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR45L gene

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

WDR45L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M078165: (about GC identifiers)

Start:	78,165,727 bp from pter
End:	78,199,700 bp from pter
Size:	33,974 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010663.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6 (See protein sequence)

Recommended Name: WD repeat domain phosphoinositide-interacting protein 3

Size: 344 amino acids; 38122 Da

Secondary accessions: O95328 Q6IBN2

REFSEQ proteins: NP_062559.2

ENSEMBL proteins:

ENSP00000376139 ENSP00000269395

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (WDR45L)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR45L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR45L
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR45L

Assays for WDR45L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5MNZ6

ProtoNet protein and cluster: Q5MNZ6

UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6

Similarity: Contains 2 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR45L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019613

Applied Biosystems Silencer® siRNAs for WDR45L

Sigma-Aldrich siRNA for WDR45L

Sigma-Aldrich shRNA for WDR45L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR45L
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019613
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019613
untagged cDNA clones in CMV expression vector (see all 2): NM_019613

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019613

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR45L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR45L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019613

Sigma-Aldrich siRNA for WDR45L

Sigma-Aldrich shRNA for WDR45L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019613

REFSEQ mRNAs for WDR45L gene:

NM_019613.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019613

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019613
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019613
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_019613

Additional cDNA sequence:

AF091083.1 AK297477.1 AM182326.1 AY691427.1 CR456770.1 CR593190.1 CR598197.1 CR600994.1

CR618973.1

18 DOTS entries:

DT.75169403 DT.97860140 DT.95262933 DT.97775512 DT.100825891 DT.95262943 DT.95262932 DT.100825904

DT.100825895 DT.120955573 DT.75179107 DT.100670371 DT.100825894 DT.75136092 DT.91754270 DT.97786349

DT.99962921 DT.121012711

24/427 AceView cDNA sequences (see all 427 ):

AW271808 BU177532 BU159659 BE907221 BU608830 BM471244 BM982729 CA952888

AI193929 AI984250 T35856 BF589058 AI582918 T35423 BM562897 BQ668847

AW749361 BM700053 BG760850 BM712368 CR593190 CR600994 BM263788 BX487284

highest scoring ESTs for WDR45L:

AF091083 AA027069 AA054504 AA054575 AA090489 AA094996 AA099601 AA099607 AA101762 AA101763

Unigene Cluster for WDR45L:

WDR45-like

Hs.132161 [show with all ESTs]

Unigene Representative Sequence: NM_019613

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for WDR45L (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13	^	14	^	15
SP1:											-				-				-		-
SP2:											-				-				-		-								-
SP3:															-				-		-
SP4:											-								-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for WDR45L

2 Ensembl transcripts including schematic representations:

ENST00000392325 ENST00000269395

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR45L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR45L

¹ / ² / ³

3 probe-sets matching WDR45L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39185_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF091083	0.80	1.00	0.91	1
209076_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000974	0.60	1.00	0.82	1
209076_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGTTTAATT

SOURCE GeneReport for Unigene cluster: Hs.132161
UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and
pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR45L gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR45L¹	--	WDR45-like	91.72(n) 99.69(a)	480820 XM_537936.2 XP_537936.2
chimpanzee (Pan troglodytes)	WDR45L¹	--	WDR45-like	94.97(n) 95.86(a)	745537 XM_001168446.1 XP_001168446.1
cow (Bos taurus)	WDR45L¹	--	WDR45-like	92.15(n) 99.13(a)	506232 NM_001075247.1 NP_001068715.1
rat (Rattus norvegicus)	Wdr45l¹	--	Wdr45 like	90.21(n) 99.13(a)	360682 NM_001039587.1 NP_001034676.1
mouse (Mus musculus)	Wdr45l^{1, 5}	11 (3.40 cM)⁵	Wdr45 like^{1, 5}	90.99(n)¹ 99.13(a)¹	66840¹ NM_025793.2¹ NP_080069.2¹ AA408735⁵ AK002352⁵ (see all 36)

About this table Species with no ortholog for WDR45L

ENSEMBL Gene Tree for WDR45L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR45L gene

WIPI1² WIPI2² WDR45²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/233 NCBI SNPs in WDR45L are shown (see all 233 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1059672^1,2	A,C,F,H,O	78165917(-)	`CGAGTC/TCTCGG`	1	--	ut3¹		10		MN EU EA WA	1210
	rs4789816^1,2	A,C,F,H	78201119(+)	`CCTCGC/ACACTT`	1	--	ng3¹		9		NA EU EA WA	732
	rs8068482^1,2	A,C,F,H	78201438(+)	`GTACCG/AGTACC`	1	--	ng3¹		8		EU EA WA NA	624
	rs4789817^1,2	A,C,F,H	78201278(+)	`ACCAGA/GAGCCT`	1	--	ng3¹		18		EA NA EU WA	1644
--	rs3764356^1,2	A,C,F	78166970(+)	`GACCAA/GGGTCC`	1	--	ut3¹ ese³		1		EA	1496
--	rs9271^1,2	C,F,H	78166561(-)	`AAAAAC/TGACCT`	1	--	ut3¹		11		MN NS EU EA WA	896
--	rs9674822^1,2	A,C	78165446(+)	`TCCCGA/CCACAG`	1	--	ng5¹		0	--	--	--	--
--	rs11867350^1,2	A,C	78165420(+)	`GGGAGA/TGAGGA`	1	--	ng5¹		0	--	--	--	--
--	rs11870689^1,2	A	78165374(+)	`TCCCGA/CCACAG`	1	--	ng5¹		0	--	--	--	--
--	rs12938675^1,2	A	78165492(+)	`GGGAGA/TGAGGA`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for WDR45L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609226

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for WDR45L gene:

WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PubMed id 15602573)^{3, 4} Proikas-Cezanne T....Nordheim A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)³ Brandenberger R.... Stanton L.W. (2004)
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49. (PubMed id 15020712)³ Jeffries T.R.... Parker P.J. (2004)
The sequence of the human genome. (PubMed id 11181995)³ Venter J.C....Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 56270	HGNC: 25072	AceView: WDR45L	Ensembl:ENSG00000141580	euGenes: HUgn56270
ECgene: WDR45L	H-InvDB: WDR45L

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR45L
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR45L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR45L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR45L		Antibodies for WDR45L
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WDR45L Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for WDR45L

Summaries
for WDR45L

Genomic Location
for WDR45L

Proteins
for WDR45L

Protein Domains/
Families
for WDR45L

Gene Function
for WDR45L

Pathways & Interactions
for WDR45L

Drugs & Compounds
for WDR45L

Transcripts
for WDR45L

Expression
for WDR45L

Orthologs
for WDR45L

Paralogs
for WDR45L

SNPs/Variants
for WDR45L

Disorders & Mutations
for WDR45L

Medical News
for WDR45L

Publications
for WDR45L

Search for WDR45L

Genome Databases showing WDR45L

Other Databases showing WDR45L

Specialized Databases showing WDR45L

Licensable Technologies
for WDR45L

Services
for WDR45L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR45L Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor WDR45L

Summariesfor WDR45L

Genomic Locationfor WDR45L

Proteinsfor WDR45L

Protein Domains/Familiesfor WDR45L

Gene Functionfor WDR45L

Pathways & Interactionsfor WDR45L

Drugs & Compoundsfor WDR45L

Transcriptsfor WDR45L

Expression for WDR45L

Orthologsfor WDR45L

Paralogsfor WDR45L

SNPs/Variantsfor WDR45L

Disorders & Mutationsfor WDR45L

Medical Newsfor WDR45L

Publicationsfor WDR45L

Search for WDR45L

Genome Databases showing WDR45L

Other Databases showing WDR45L

Specialized Databases showing WDR45L

Licensable Technologiesfor WDR45L

Servicesfor WDR45L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR45L

Summaries
for WDR45L

Genomic Location
for WDR45L

Proteins
for WDR45L

Protein Domains/
Families
for WDR45L

Gene Function
for WDR45L

Pathways & Interactions
for WDR45L

Drugs & Compounds
for WDR45L

Transcripts
for WDR45L

Expression
for WDR45L

Orthologs
for WDR45L

Paralogs
for WDR45L

SNPs/Variants
for WDR45L

Disorders & Mutations
for WDR45L

Medical News
for WDR45L

Publications
for WDR45L

Licensable Technologies
for WDR45L

Services
for WDR45L