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Aliases for WDR45B Gene

Aliases for WDR45B Gene

  • WD Repeat Domain 45B 2 3
  • WD Repeat-Containing Protein 45-Like 3 4
  • WD Repeat-Containing Protein 45B 3 4
  • WIPI49-Like Protein 3 4
  • WDR45-Like Protein 3 4
  • WDR45L 3 4
  • WIPI-3 3 4
  • WIPI3 3 4
  • WD Repeat Protein 45-Like 3
  • WDR45-Like 2

External Ids for WDR45B Gene

Previous HGNC Symbols for WDR45B Gene

  • WDR45L

Previous GeneCards Identifiers for WDR45B Gene

  • GC17M080574

Summaries for WDR45B Gene

Entrez Gene Summary for WDR45B Gene

  • This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR45B Gene

WDR45B (WD Repeat Domain 45B) is a Protein Coding gene. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is ENSG00000250232.

Gene Wiki entry for WDR45B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR45B Gene

Genomics for WDR45B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR45B Gene

Chromosome:
17
Start:
82,614,562 bp from pter
End:
82,648,553 bp from pter
Size:
33,992 bases
Orientation:
Minus strand

Genomic View for WDR45B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR45B Gene

No data available for Regulatory Elements for WDR45B Gene

Proteins for WDR45B Gene

  • Protein details for WDR45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNZ6-WIPI3_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 3
    Protein Accession:
    Q5MNZ6
    Secondary Accessions:
    • O95328
    • Q2MCP6
    • Q6IBN2

    Protein attributes for WDR45B Gene

    Size:
    344 amino acids
    Molecular mass:
    38122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72952.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR45B Gene

Proteomics data for WDR45B Gene at MOPED

Post-translational modifications for WDR45B Gene

  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR45B Gene

No data available for DME Specific Peptides for WDR45B Gene

Domains & Families for WDR45B Gene

Gene Families for WDR45B Gene

Protein Domains for WDR45B Gene

Suggested Antigen Peptide Sequences for WDR45B Gene

Graphical View of Domain Structure for InterPro Entry

Q5MNZ6

UniProtKB/Swiss-Prot:

WIPI3_HUMAN :
  • Belongs to the WD repeat SVP1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat SVP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR45B: view

Function for WDR45B Gene

Gene Ontology (GO) - Molecular Function for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0032266 phosphatidylinositol-3-phosphate binding IBA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with WDR45B: view

Phenotypes for WDR45B Gene

GenomeRNAi human phenotypes for WDR45B:
genes like me logo Genes that share phenotypes with WDR45B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR45B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR45B Gene

Localization for WDR45B Gene

Gene Ontology (GO) - Cellular Components for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 pre-autophagosomal structure membrane IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for WDR45B Gene

Pathways & Interactions for WDR45B Gene

genes like me logo Genes that share pathways with WDR45B: view

Pathways by source for WDR45B Gene

2 Reactome pathways for WDR45B Gene

Gene Ontology (GO) - Biological Process for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006497 protein lipidation IBA --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0034497 protein localization to pre-autophagosomal structure IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for SIGNOR curated interactions for WDR45B Gene

Drugs & Compounds for WDR45B Gene

No Compound Related Data Available

Transcripts for WDR45B Gene

Unigene Clusters for WDR45B Gene

WD repeat domain 45B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for WDR45B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR45B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: - - - - -
SP8:

Relevant External Links for WDR45B Gene

GeneLoc Exon Structure for
WDR45B
ECgene alternative splicing isoforms for
WDR45B

Expression for WDR45B Gene

mRNA expression in normal human tissues for WDR45B Gene

Protein differential expression in normal tissues from HIPED for WDR45B Gene

This gene is overexpressed in Breast (39.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR45B Gene



SOURCE GeneReport for Unigene cluster for WDR45B Gene Hs.132161

mRNA Expression by UniProt/SwissProt for WDR45B Gene

Q5MNZ6-WIPI3_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.
genes like me logo Genes that share expression patterns with WDR45B: view

Protein tissue co-expression partners for WDR45B Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR45B Gene

Orthologs for WDR45B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR45B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR45L 35
  • 92.15 (n)
  • 99.13 (a)
WDR45L 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR45B 35
  • 91.72 (n)
  • 99.69 (a)
WDR45B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr45b 35
  • 90.99 (n)
  • 99.13 (a)
Wdr45b 16
Wdr45b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR45L 35
  • 99.61 (n)
  • 100 (a)
WDR45L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr45b 35
  • 90.21 (n)
  • 99.13 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR45B 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR45B 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR45L 35
  • 87.5 (n)
  • 97.38 (a)
WDR45B 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR45B 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr45b 35
  • 82.27 (n)
  • 97.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5528 35
zebrafish
(Danio rerio)
Actinopterygii wdr45l 35
  • 80.23 (n)
  • 95.64 (a)
zgc56002 35
wdr45l 36
  • 96 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012792 35
  • 64.04 (n)
  • 67.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11975 35
  • 64.5 (n)
  • 68.73 (a)
CG11975 36
  • 69 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSV2 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG18C 35
  • 51.15 (n)
  • 47.5 (a)
rice
(Oryza sativa)
Liliopsida Os01g0168500 35
  • 54.45 (n)
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.576 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for WDR45B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR45B Gene

ENSEMBL:
Gene Tree for WDR45B (if available)
TreeFam:
Gene Tree for WDR45B (if available)

Paralogs for WDR45B Gene

Paralogs for WDR45B Gene

(3) SIMAP similar genes for WDR45B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for WDR45B Gene

genes like me logo Genes that share paralogs with WDR45B: view

Variants for WDR45B Gene

Sequence variations from dbSNP and Humsavar for WDR45B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9271 -- 82,615,396(-) AAAAA(C/T)GACCT utr-variant-3-prime, nc-transcript-variant
rs753569 -- 82,616,206(+) CTGAC(G/T)GTCTT intron-variant
rs901374 -- 82,628,654(+) ATCAC(A/C/T)CCACT intron-variant
rs965521 -- 82,629,712(+) TTCAC(A/G)CAGTT intron-variant, utr-variant-5-prime
rs1059672 -- 82,614,752(-) CGAGT(C/T)CTCGG utr-variant-3-prime, nc-transcript-variant

Variation tolerance for WDR45B Gene

Residual Variation Intolerance Score: 18.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR45B Gene

HapMap Linkage Disequilibrium report
WDR45B
Human Gene Mutation Database (HGMD)
WDR45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for WDR45B Gene

Disorders for WDR45B Gene

Relevant External Links for WDR45B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR45B
genes like me logo Genes that share disorders with WDR45B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR45B Gene

Publications for WDR45B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67

Products for WDR45B Gene

Sources for WDR45B Gene

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