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Aliases for WDR45B Gene

Aliases for WDR45B Gene

  • WD Repeat Domain 45B 2 3 5
  • WD Repeat-Containing Protein 45-Like 3 4
  • WD Repeat-Containing Protein 45B 3 4
  • WIPI49-Like Protein 3 4
  • WDR45-Like Protein 3 4
  • WDR45L 3 4
  • WIPI-3 3 4
  • WIPI3 3 4
  • WD Repeat Domain Phosphoinositide-Interacting Protein 3 3
  • WD Repeat Protein 45-Like 3
  • WDR45-Like 2

External Ids for WDR45B Gene

Previous HGNC Symbols for WDR45B Gene

  • WDR45L

Previous GeneCards Identifiers for WDR45B Gene

  • GC17M080574

Summaries for WDR45B Gene

Entrez Gene Summary for WDR45B Gene

  • This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR45B Gene

WDR45B (WD Repeat Domain 45B) is a Protein Coding gene. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include phosphatidylinositol-3-phosphate binding and phosphatidylinositol-3,5-bisphosphate binding. An important paralog of this gene is WDR45.

Gene Wiki entry for WDR45B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR45B Gene

Genomics for WDR45B Gene

Regulatory Elements for WDR45B Gene

Enhancers for WDR45B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F082627 0.9 Ensembl ENCODE 27.2 +20.1 20054 2.6 ZFHX2 POLR2A SMARCA4 BHLHE40 FOS MAFK PRDM1 EGR2 WDR45B FN3K TEX19 RAB40B GC17M082606 ENSG00000261845
GH17F082590 1.5 FANTOM5 ENCODE 23.4 +56.1 56082 3.5 PKNOX1 KLF17 SIN3A BRCA1 ZNF121 ZNF366 ZNF143 CREM EGR2 HCFC1 WDR45B LOC101929552 FN3K RAB40B LOC105371942 ENSG00000261845
GH17F082596 0.2 ENCODE 21.5 +52.5 52454 0.1 SCRT2 WDR45B ENSG00000261845 LOC105371942
GH17F082669 0.6 ENCODE 20.4 -21.5 -21475 1.0 NR2F2 WDR45B FN3K LOC101929552 FN3KRP ENSG00000262663 MIR4525 GC17M082673
GH17F082601 0.2 ENCODE 18.8 +45.3 45270 3.1 HDGF USF1 MAX PLRG1 ZNF664 POLR2A CREM CBFB BHLHE40 JUNB WDR45B LOC105371942 FOXK2 ENSG00000261845
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around WDR45B on UCSC Golden Path with GeneCards custom track

Promoters for WDR45B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001355776 353 2401 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF143 FOS

Genomic Location for WDR45B Gene

Chromosome:
17
Start:
82,614,562 bp from pter
End:
82,648,553 bp from pter
Size:
33,992 bases
Orientation:
Minus strand

Genomic View for WDR45B Gene

Genes around WDR45B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR45B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR45B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR45B Gene

Proteins for WDR45B Gene

  • Protein details for WDR45B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5MNZ6-WIPI3_HUMAN
    Recommended name:
    WD repeat domain phosphoinositide-interacting protein 3
    Protein Accession:
    Q5MNZ6
    Secondary Accessions:
    • O95328
    • Q2MCP6
    • Q6IBN2

    Protein attributes for WDR45B Gene

    Size:
    344 amino acids
    Molecular mass:
    38122 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC72952.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR45B Gene

Post-translational modifications for WDR45B Gene

  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR45B Gene

No data available for DME Specific Peptides for WDR45B Gene

Domains & Families for WDR45B Gene

Gene Families for WDR45B Gene

Protein Domains for WDR45B Gene

Suggested Antigen Peptide Sequences for WDR45B Gene

Graphical View of Domain Structure for InterPro Entry

Q5MNZ6

UniProtKB/Swiss-Prot:

WIPI3_HUMAN :
  • Belongs to the WD repeat SVP1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat SVP1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR45B: view

Function for WDR45B Gene

Gene Ontology (GO) - Molecular Function for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032266 phosphatidylinositol-3-phosphate binding IBA --
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding IBA --
genes like me logo Genes that share ontologies with WDR45B: view
genes like me logo Genes that share phenotypes with WDR45B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR45B Gene

Localization for WDR45B Gene

Gene Ontology (GO) - Cellular Components for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0019898 extrinsic component of membrane IBA --
GO:0034045 pre-autophagosomal structure membrane IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for WDR45B Gene

Pathways & Interactions for WDR45B Gene

SuperPathways for WDR45B Gene

genes like me logo Genes that share pathways with WDR45B: view

Pathways by source for WDR45B Gene

2 Reactome pathways for WDR45B Gene

Gene Ontology (GO) - Biological Process for WDR45B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006497 protein lipidation IBA --
GO:0034497 protein localization to pre-autophagosomal structure IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with WDR45B: view

No data available for SIGNOR curated interactions for WDR45B Gene

Transcripts for WDR45B Gene

Unigene Clusters for WDR45B Gene

WD repeat domain 45B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR45B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6: - -
SP7: - - - - -
SP8:

Relevant External Links for WDR45B Gene

GeneLoc Exon Structure for
WDR45B
ECgene alternative splicing isoforms for
WDR45B

Expression for WDR45B Gene

mRNA expression in normal human tissues for WDR45B Gene

Protein differential expression in normal tissues from HIPED for WDR45B Gene

This gene is overexpressed in Breast (39.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR45B Gene



Protein tissue co-expression partners for WDR45B Gene

NURSA nuclear receptor signaling pathways regulating expression of WDR45B Gene:

WDR45B

SOURCE GeneReport for Unigene cluster for WDR45B Gene:

Hs.132161

mRNA Expression by UniProt/SwissProt for WDR45B Gene:

Q5MNZ6-WIPI3_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated in a variety of tumor tissues including ovarian and uterine cancers.
genes like me logo Genes that share expression patterns with WDR45B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR45B Gene

Orthologs for WDR45B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR45B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR45L 34 35
  • 99.61 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR45B 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR45L 34 35
  • 92.15 (n)
dog
(Canis familiaris)
Mammalia WDR45B 34 35
  • 91.72 (n)
mouse
(Mus musculus)
Mammalia Wdr45b 34 16 35
  • 90.99 (n)
rat
(Rattus norvegicus)
Mammalia Wdr45b 34
  • 90.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia WDR45B 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR45B 35
  • 97 (a)
OneToOne
WDR45L 34
  • 87.5 (n)
lizard
(Anolis carolinensis)
Reptilia WDR45B 35
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr45b 34
  • 82.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5528 34
zebrafish
(Danio rerio)
Actinopterygii wdr45l 34 35
  • 80.23 (n)
zgc56002 34
fruit fly
(Drosophila melanogaster)
Insecta CG11975 34 35
  • 64.5 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012792 34
  • 64.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSV2 35
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ATG18C 34
  • 51.15 (n)
rice
(Oryza sativa)
Liliopsida Os01g0168500 34
  • 54.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.576 34
Species where no ortholog for WDR45B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR45B Gene

ENSEMBL:
Gene Tree for WDR45B (if available)
TreeFam:
Gene Tree for WDR45B (if available)

Paralogs for WDR45B Gene

Paralogs for WDR45B Gene

(3) SIMAP similar genes for WDR45B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for WDR45B Gene

genes like me logo Genes that share paralogs with WDR45B: view

Variants for WDR45B Gene

Sequence variations from dbSNP and Humsavar for WDR45B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs786205510 Likely pathogenic 82,619,074(-) AACTG(C/T)GAAGA nc-transcript-variant, reference, stop-gained
rs10445246 -- 82,617,465(+) CCACA(A/G)CACTT intron-variant
rs1059672 -- 82,614,752(-) CGAGT(C/T)CTCGG nc-transcript-variant, utr-variant-3-prime
rs111276463 -- 82,623,110(+) CTTAC(C/G)GCCGG intron-variant
rs111280395 -- 82,631,332(+) AGGCT(A/G)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR45B Gene

Variant ID Type Subtype PubMed ID
esv1010132 CNV insertion 20482838
esv1510304 CNV insertion 17803354
esv21913 CNV gain+loss 19812545
esv2668610 CNV deletion 23128226
esv2675908 CNV deletion 23128226
esv2716511 CNV deletion 23290073
esv2716512 CNV deletion 23290073
esv2762577 CNV gain+loss 21179565
esv3448719 CNV insertion 20981092
esv3641433 CNV loss 21293372
esv3641435 CNV loss 21293372
nsv1062980 CNV gain 25217958
nsv1067194 CNV gain 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914

Variation tolerance for WDR45B Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR45B Gene

Human Gene Mutation Database (HGMD)
WDR45B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR45B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR45B Gene

Disorders for WDR45B Gene

Relevant External Links for WDR45B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR45B

No disorders were found for WDR45B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR45B Gene

Publications for WDR45B Gene

  1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PMID: 15602573) Proikas-Cezanne T. … Nordheim A. (Oncogene 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. (PMID: 26389662) Raman M. … Harper J.W. (Nat. Cell Biol. 2015) 3 64
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64

Products for WDR45B Gene

Sources for WDR45B Gene

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