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WDR45B Gene

protein-coding   GIFtS: 40
GCID: GC17M080574

WD Repeat Domain 45B

(Previous name: WDR45-like)
(Previous symbol: WDR45L)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 45B1 2     WDR45-Like Protein2 3
WDR45L1 2 3     WIPI49-Like Protein2 3
WIPI-32 3     WDR45-like1
WIPI32 3     WD Repeat Domain Phosphoinositide-Interacting Protein 32
WD Repeat-Containing Protein 45-Like2 3     WD Repeat Protein 45-Like2
WD Repeat-Containing Protein 45B2 3     

External Ids:    HGNC: 250721   Entrez Gene: 562702   Ensembl: ENSG000001415807   OMIM: 6092265   UniProtKB: Q5MNZ63   

Export aliases for WDR45B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR45B Gene:
This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains
seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein
interactions, and a conserved motif for interaction with phospholipids. The human genome contains several
pseudogenes of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for WDR45B Gene:
WDR45B (WD repeat domain 45B) is a protein-coding gene. GO annotations related to this gene include phosphatidylinositol-3,5-bisphosphate binding and phosphatidylinositol-3-phosphate binding. An important paralog of this gene is ENSG00000250232.

Gene Wiki entry for WDR45B (WDR45L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010663.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for WDR45B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR45B promoter sequence
   Search Chromatin IP Primers for WDR45B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR45B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

WDR45B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR45B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M080574:  view genomic region     (about GC identifiers)

Start:
80,572,438 bp from pter      End:
80,606,429 bp from pter
Size:
33,992 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6 (See protein sequence)
Recommended Name: WD repeat domain phosphoinositide-interacting protein 3  
Size: 344 amino acids; 38122 Da
Sequence caution: Sequence=AAC72952.1; Type=Erroneous initiation;
Secondary accessions: O95328 Q2MCP6 Q6IBN2

Explore the universe of human proteins at neXtProt for WDR45B: NX_Q5MNZ6

Explore proteomics data for WDR45B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys278
  • Modification sites at PhosphoSitePlus

  • See WDR45B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_062559.2  
    ENSEMBL proteins: 
     ENSP00000376139   ENSP00000461488   ENSP00000460297   ENSP00000458738   ENSP00000461355  

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    antibodies-online proteins for WDR45B (5 products) 

     
    antibodies-online peptides for WDR45B

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    antibodies-online antibodies for WDR45B (18 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5MNZ6

    ProtoNet protein and cluster: Q5MNZ6

    UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6
    Similarity: Belongs to the WD repeat SVP1 family
    Similarity: Contains 2 WD repeats


    Find genes that share domains with WDR45B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0032266phosphatidylinositol-3-phosphate binding IBA--
    GO:0080025phosphatidylinositol-3,5-bisphosphate binding IBA--
         
    Find genes that share ontologies with WDR45B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDR45B

    miRNA
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    miRTarBase miRNAs that target WDR45B:
    hsa-mir-766-3p (MIRT039009), hsa-mir-744-5p (MIRT037428)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with WDR45B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR45B
    Interactions:

        Search GeneGlobe Interaction Network for WDR45B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for WDR45B (Q5MNZ63 ENSP000003761394) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly IBA--

    Find genes that share ontologies with WDR45B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR45B (WIPI3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR45B gene: 
    NM_019613.3  

    Unigene Cluster for WDR45B:

    WD repeat domain 45B
    Hs.132161  [show with all ESTs]
    Unigene Representative Sequence: NM_019613
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392325(uc002kfq.3 uc002kfr.3) ENST00000572583 ENST00000576517
    ENST00000573656 ENST00000571835 ENST00000573616 ENST00000577774 ENST00000571767
    ENST00000571817 ENST00000574828
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat WDR45B

    Additional mRNA sequence: 

    AF091083.1 AK297477.1 AM182326.1 AY691427.1 CR456770.1 

    18 DOTS entries:

    DT.75169403  DT.97860140  DT.95262933  DT.97775512  DT.100825891  DT.95262943  DT.95262932  DT.100825904 
    DT.100825895  DT.120955573  DT.100670371  DT.100825894  DT.75136092  DT.91754270  DT.97786349  DT.99962921 
    DT.121012711  DT.75179107 

    Selected AceView cDNA sequences (see all 427):

    BQ668847 CR598197 AL708671 BQ021374 AA831683 BQ687030 BU633525 AI582918 
    T34905 AW271808 BM846358 BF589058 BM562897 BE907221 BF343474 BM471244 
    AI920937 BU159659 BQ883510 CA952888 BM763966 BM712368 BM982729 AW749361 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR45B (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15
    SP1:                                -           -           -     -                                                                           
    SP2:                                -           -           -     -                       -                                                   
    SP3:                                            -           -     -                                                                           
    SP4:                                -                       -     -                                                                           
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for WDR45B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR45B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    WDR45B Expression
    About this image

    WDR45B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR45B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132161

    UniProtKB/Swiss-Prot: WIPI3_HUMAN, Q5MNZ6
    Tissue specificity: Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Up-regulated
    in a variety of tumor tissues including ovarian and uterine cancers

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR45B gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr45b1 , 5 Wdr45 like5
    WD repeat domain 45B1
    90.99(n)1
    99.13(a)1
      11 (85.24 cM)5
    668401  NM_025793.31  NP_080069.21 
     1213272245 
    chicken
    (Gallus gallus)
    Aves WDR45L1 WDR45-like 87.5(n)
    97.38(a)
      417339  NM_001007844.1  NP_001007845.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR45B6
    WD repeat domain 45B
    96(a)
    1 ↔ 1
    2(103663742-103678566)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55282 Xenopus laevis transcribed sequence with strong similarity more 81.16(n)    CA789358.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560022 hypothetical protein MGC56002 80.44(n)   393210  BC047802.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119751 CG11975 64.5(n)
    68.73(a)
      41074  NM_001275465.1  NP_001262394.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSV26
    Phosphatidylinositol 3,5-bisphosphate-binding prot...
    26(a)
    1 → many
    VII(940869-942215) YGR223C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG18C1 ATG18C 51.15(n)
    47.5(a)
      818678  NM_201921.1  NP_973650.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01685001 Os01g0168500 54.45(n)
    50(a)
      4325192  NM_001048665.1  NP_001042130.1 


    ENSEMBL Gene Tree for WDR45B (if available)
    TreeFam Gene Tree for WDR45B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR45B gene
    ENSG000002502322  WDR452  
    3 SIMAP similar genes for WDR45B using alignment to 5 protein entries:     WIPI3_HUMAN (see all proteins):
    WDR45L    WDR45    WIPI1

    Find genes that share paralogs with WDR45B           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for WDR45B
    PGOHUM00000237024 PGOHUM00000235042 PGOHUM00000236295


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR45B (see all 893)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80709741,2
    C,H--80571972(+) GCCCTC/TGGGGC 1 -- ds500111Minor allele frequency- T:0.02NA WA CSA EA 372
    rs1442990191,2
    C--80572007(+) CCCGT-/CCCCGA 1 -- ds50010--------
    rs1872627421,2
    --80572084(+) GTCCCA/GCCACA 1 -- ds50010--------
    rs118706891,2
    C,F,A,H--80572085(+) TCCCGC/ACACAG 1 -- ds50012Minor allele frequency- A:0.25NA 4
    rs118673461,2
    C,F,A,H--80572095(+) GGGAGT/AGAGGA 1 -- ds50014Minor allele frequency- A:0.38NA WA 8
    rs591076381,2
    C--80572111(+) GGCCGC/TCCCGT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs96748201,2
    C,H--80572121(+) TCCCGA/CCACAG 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs118673501,2
    C,F,A,H--80572131(+) GGGAGT/AGAGGA 1 -- ds50014Minor allele frequency- A:0.38NA WA 8
    rs96748221,2
    C,A--80572157(+) TCCCGA/CCACAG 1 -- ds50012Minor allele frequency- C:0.25NA 4
    rs129384161,2
    C,A--80572167(+) GGGAGT/AGAGGA 1 -- ds50011Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for WDR45B (80572438 - 80606429 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for WDR45B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR45B
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR45B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609226    OMIM disorders: --


    Find genes that share disorders with WDR45B           About GenesLikeMe


    Export disorders for WDR45B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR45B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with WDR45B)
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    1. WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy. (PubMed id 15602573)1, 2 Proikas-Cezanne T....Nordheim A. (Oncogene 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56270 HGNC: 25072 AceView: WDR45L Ensembl:ENSG00000141580 euGenes: HUgn56270
    ECgene: WDR45B H-InvDB: WDR45B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR45B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for WDR45B gene:
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