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WDR45 Gene

protein-coding   GIFtS: 49

GC0XM048819
WD repeat domain 45
(Previous names: WD repeat domain, X-linked 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: WDRX1)
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Aliases &
Descriptions
for WDR45

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
JM5 1, 2
OTTHUMP00000032409 2
WDRX1 2, 3
WDRXI4 3
WIPI-4 2, 3
WIPI4 1, 2, 3
Descriptions
WD repeat domain 45 2
WD repeat domain, X-linked 1 1, 2
WD repeat-containing protein 45 3
WD45 repeat protein interacting with phosphoinositides 4 2
External Ids
HGNC: 289121
Entrez Gene: 111522
UniProtKB: Q9Y4843
Ensembl: ENSG000001969987
Search outside databases for aliases for WDR45 gene

Previous GC identifer: GC0XM048688

Summaries
for WDR45

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for WDR45:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. This gene has a pseudogene at chromosome 4q31.3.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for
this gene, but the biological validity and full-length nature of some variants have not been
determined. [provided by RefSeq]

Gene Wiki entry for WDR45

Genomic Location
for WDR45

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR45 gene  

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

WDR45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048819:     (about GC identifiers)

Start:
 48,819,036 bp from pter
End:
 48,845,003 bp from pter
Size:
 25,968 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000023.9  NT_079573.3  

Proteins
for WDR45

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: WIPI4_HUMAN, Q9Y484 (See protein sequence)
Recommended Name: WD repeat domain phosphoinositide-interacting protein 4  
Size: 360 amino acids; 39868 Da
Secondary accessions: Q5MNZ5 Q6IBS7 Q6NT94 Q96H03
Alternative splicing: 3 isoforms:  Q9Y484-1   Q9Y484-2   Q9Y484-3   

REFSEQ proteins (2 alternative transcripts): 
NP_001025067.1  NP_009006.2  


ENSEMBL proteins: 
ENSP00000365543 ENSP00000365539 ENSP00000365535 ENSP00000365536 ENSP00000365546 ENSP00000379913 
ENSP00000365551 ENSP00000348848 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (WDR45)
Human Recombinant Proteins from Abnova (WDR45)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR45: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for WDR45
Browse R&D Systems for Antibodies
Antibodies from Abcam (WDR45), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (WDR45)
Novus Biologicals Antibodies for WDR45

Assays for WDR45: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for WDR45

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR019775 WD40_repeat_CS
 IPR001680 WD40_repeat
 IPR015943 WD40/YVTN_repeat-like


   GeneDecks  WDR45 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9Y484

ProtoNet protein and cluster: Q9Y484

UniProtKB/Swiss-Prot: WIPI4_HUMAN, Q9Y484
Similarity: Contains 3 WD repeats

Gene Function
for WDR45

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR45)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007075

              Applied Biosystems Silencer® siRNAs for WDR45

              Sigma-Aldrich siRNA for WDR45  
                     Sigma-Aldrich shRNA for WDR45  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for WDR45
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001029896
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001029896
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001029896 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_007075

Pathways & Interactions
for WDR45

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for WDR45

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR45

Transcripts
for WDR45

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR45)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_007075

              Sigma-Aldrich siRNA for WDR45  
                     Sigma-Aldrich shRNA for WDR45  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001029896  NM_007075  

REFSEQ mRNAs for WDR45 gene (2 alternative transcripts): 

NM_001029896.1   NM_007075.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001029896  NM_007075  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001029896
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001029896
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001029896 

Additional cDNA sequence: 

AJ005897.1 AK023344.1 AK225122.1 AK301084.1 AK315717.1 AY691428.1 BC000464.2 BC003037.1 
BC009027.1 BC035979.1 BC069206.1 CR456725.1 CR590613.1 CR592753.1 CR594026.1 CR595931.1 
CR604542.1 CR608446.1 

19 DOTS entries:

DT.455388  DT.92435693  DT.40249386  DT.97816224  DT.95358721  DT.100817695  DT.92020572  DT.121290070 
DT.97859431  DT.121290043  DT.95077499  DT.121290027  DT.100817693  DT.121262060  DT.121290014  DT.121290029 
DT.92036934  DT.95123900  DT.91877747 

24/273 AceView cDNA sequences (see all 273 ):

BF985223 BM791632 CA306278 CR594026 AA436357 BC003037 BU608234 AK023344 
CR608446 BM786175 AI245886 CR590613 BM705389 BM013712 AI521747 BM763260 
BI258615 CR604542 BM974891 AI669331 BC000464 AI669196 AU076556 BF929146 

highest scoring ESTs for WDR45:

BC069206 AA001750 AA013110 AA013111 AA079679 AA079809 AA100453 AA100454 AA324244 AA337832 

Unigene Cluster for WDR45:

WD repeat domain 45
Hs.632807  [show with all ESTs]
Unigene Representative Sequence: BC035979


GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for WDR45 (see all 13 )

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1:                                                                          -     -     -     -     -     -                 -     -                           
SP2:                                                                          -     -     -     -     -     -                 -     -                           
SP3:                                                                    -     -     -     -     -     -     -                 -     -                           
SP4:                                                                                                                          -     -                           
SP5:                                                                                                                          -                                 

ExUns: 14b ^ 15a · 15b · 15c ^ 16
SP1:  -                           
SP2:                              
SP3:  -                           
SP4:  -                           
SP5:  -                           

About this scheme

ECgene alternative splicing isoforms for WDR45

8 Ensembl transcripts including schematic representations:
ENST00000322995  ENST00000376361  ENST00000376357  ENST00000376358  ENST00000376368  ENST00000396681  
ENST00000376372  ENST00000356463  

Expression
for WDR45

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR45 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR45

1 / 2 / 3

5 probe-sets matching WDR45 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
33350_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Z78315 0.60 1.00 0.82 1

209216_at2, 3 U133-A 1 1.00 1.00 -- -- BC000464 0.60 1.00 0.82 1

209217_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC000464 0.60 1.00 0.82 1

209216_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

209217_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  WDR45 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACAAGATCGT

SOURCE GeneReport for Unigene cluster: Hs.632807

UniProtKB/Swiss-Prot: WIPI4_HUMAN, Q9Y484
Tissue specificity: Ubiquitously expressed, with high expression in skeletal muscle and heart.
Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney
tumors

Orthologs
for WDR45

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for WDR45 gene from 5/10 species (see all 10 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 WDR451   -- WD repeat domain 45 93.43(n)
98.06(a)		 612890  XM_846382.1  XP_851475.1 
chimpanzee
(Pan troglodytes)		 WDR451   -- WD repeat domain 45 99.81(n)
100(a)		 465626  XM_001141167.1  XP_001141167.1 
cow
(Bos taurus)		 WDR451   -- WD repeat domain 45 92.96(n)
99.17(a)		 539190  NM_001076151.1  NP_001069619.1 
mouse
(Mus musculus)		 Wdr451, 5 X (1.60 cM)5
 WD repeat domain 451, 5 90.83(n)1
97.78(a)1		 546361  NM_172372.11  NP_758960.11 
 AF2296355  AI8441515  (see all 15)
zebrafish
(Danio rerio)		 zgc563452   -- similar to JM5 protein 77.94(n) 393200  BC046090.1 
About this table        Species with no ortholog for WDR45

ENSEMBL Gene Tree for WDR45

Paralogs
for WDR45

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR45 gene
WDR45L2  WIPI12  WIPI22  

Pseudogenes
1 related pseudogene


SNPs/Variants
for WDR45

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/89 NCBI SNPs in WDR45 are shown (see all 89 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 33)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs120086811,2
C48845191(+) CGACCA/GATCAG 1 -- ng31 tfbs30--------
rs59067361,2
C48824962(+) CTCCGA/GGAAGC 2 -- ng31 int10--------
rs120077031,2
A,C,F,H48831553(+) ccatcA/Gaggca 1 -- int14Minor allele frequency- G:0.21EU EA WA 418
rs59525131,2
A,C,F,H48820834(+) GGGTAC/GCCAGG 2 -- int14Minor allele frequency- G:0.24EU EA WA 418
rs120074491,2
C,F,H48822761(+) CTCCCC/TTCCAA 2 -- int1 trp34Minor allele frequency- T:0.10EU EA WA 416
--
rs65203961,2
A,C48839932(+) caggcA/Gtgagc 1 -- int10--------
rs66098281,2
A,C48828293(+) taatcC/Tcagca 1 -- int10--------
rs59532621,2
A,C48840635(+) GATGAC/TAtttt 1 -- int13Minor allele frequency- T:0.01NA 136
rs120082921,2
C,H48843846(+) TAAGCT/GAATTA 1 -- int14Minor allele frequency- G:0.00EU EA WA 418
--
rs48247411,2
C48833505(+) cccatC/Ttttac 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for WDR45 (up to first 250kb)

Disorders & Mutations
for WDR45

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300526

Medical News
for WDR45

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for WDR45

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for WDR45 gene:

Search for WDR45

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing WDR45

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 11152 HGNC: 28912 AceView: WDR45 Ensembl:ENSG00000196998 euGenes: HUgn11152
ECgene: WDR45 H-InvDB: WDR45

Other Databases showing WDR45

(According to HUGE)
About This Section

   --

Specialized Databases showing WDR45

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for WDR45

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for WDR45

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR45:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR45-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for WDR45 Antibodies for WDR45
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for WDR45 Browse small molecules at Sigma-Aldrich
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 Antibodies for WDR45

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