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Aliases & Descriptions for WDR44
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686L20145 1, 2 | | MGC26781 2 | | OTTHUMP00000023886 2 | | OTTHUMP00000062781 2 | | RAB11BP 1, 2 | | RPH11 1, 2 | | Rabphilin-11 3 |
| | | Descriptions |
|---|
| WD repeat domain 44 2 | | WD repeat domain 44 protein 2 |
|
| | Search outside databases for aliases for WDR44 genePrevious GC identifer: GC0XP117261 |
Summaries for WDR44(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3Function: Downstream effector for RAB11. May be involved in vesicle recycling (By similarity)Gene Wiki entry for WDR44 |
Genomic Location for WDR44
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WDR44 gene 
Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24WDR44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP117364:
(about GC identifiers)
Start:
|
117,364,070 bp from pter |
End:
|
117,474,977 bp from pter |
Size:
|
110,908 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011786.15
| Proteins for WDR44
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3 (See
protein sequence)Recommended Name: WD repeat-containing protein 44 Size: 913 amino acids; 101366 Da
Subunit: Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity)
Subcellular location: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia (By similarity)
Sequence caution: Sequence=BAA92015.1; Type=Frameshift; Positions=792;
Secondary accessions: Q0JS52 Q0JTF3 Q5JSH2 Q6ZSC1 Q7Z365 Q7Z3P6 Q8NAU8 Q8NHU5 Q9NUV4Alternative splicing: 3 isoforms: Q5JSH3-1 Q5JSH3-2 Q5JSH3-3 Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061918.3
ENSEMBL proteins: ENSP00000317678 ENSP00000360887 ENSP00000254029 ENSP00000360914 ENSP00000360890
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for WDR44: Assays for WDR44: | Protein
Domains/ Families for WDR44(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5JSH3
ProtoNet protein and cluster: Q5JSH3 UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3Similarity: Contains 7 WD repeats | Gene Function for WDR44
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019045
Applied Biosystems Silencer® siRNAs for WDR44
Sigma-Aldrich siRNA for WDR44  Sigma-Aldrich shRNA for WDR44  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019045                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019045                                  untagged cDNA clones in CMV expression vector (see all 3): NM_019045 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_019045
UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3Function: Downstream effector for RAB11. May be involved in vesicle recycling (By similarity) | Pathways & Interactions for WDR44
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for WDR44 (ENSP000003609143) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for WDR44(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WDR44
|
Transcripts for WDR44(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019045
Sigma-Aldrich siRNA for WDR44  Sigma-Aldrich shRNA for WDR44  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_019045 REFSEQ mRNAs for WDR44 gene: NM_019045.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_019045               OriGene GFP tagged cDNA clone in CMV expression vector: NM_019045                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_019045                                  untagged cDNA clones in CMV expression vector (see all 3): NM_019045  Additional cDNA sequence: AK001978.1 AK023292.1 AK092077.1 AK127556.1 AK299711.1 AK304432.1 AL833605.1 AL834210.1 BC013924.1 BC028697.2 BX537578.1 BX538087.1 BX648150.1 8 DOTS entries: DT.107510 DT.100727267 DT.91758262 DT.433975 DT.100021894 DT.92008178 DT.121324138 DT.99947417 24/81 AceView cDNA sequences (see all 81
):AW148385 BQ921584 AK092077 AI627346 BC028697 AA767059 BX538087 BX280516 BC013924 AL833605 BX648150 AA259020 NM_019045 AI074635 AW139472 AA426298 AW611931 BX470418 BU567735 AK127556 AL834210 BE871572 BX537578 BF115809
highest scoring ESTs for WDR44:AI016239 AA259020 AA344633 AA426298 AA426299 AI074635 AK001978 AK092077 AK127556 AL833605 Unigene Cluster for WDR44: WD repeat domain 44 Hs.98510 [show with all ESTs]Unigene Representative Sequence: NM_019045
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR44 (see all 6
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WDR44
5 Ensembl transcripts including schematic representations: ENST00000318919
ENST00000371822
ENST00000254029
ENST00000371848
ENST00000371825
|
Expression for WDR44
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WDR44 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WDR44
1 / 2 / 3 4 probe-sets matching WDR44 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGTTGATGG
SOURCE GeneReport for Unigene cluster: Hs.98510
|
Orthologs for WDR44
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDR44 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for WDR44
ENSEMBL Gene Tree for WDR44 | Paralogs for WDR44(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for WDR44 gene
- AHI12
|
SNPs/Variants for WDR44(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WDR44 (up to first 250kb)
|
Disorders & Mutations for WDR44
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| Human Genome Epidemiology Navigator: WDR44 (1 document)
|
Medical News for WDR44(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WDR44 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/22 PubMed articles for WDR44 gene (see all 22
):- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)3, 4 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)2, 3 Strausberg R.L....Marra M.A. (2002)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for WDR44
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR44
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WDR44
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR44(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for WDR44(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WDR44:

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Incremental update: 13 Oct 2009
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