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Aliases for WDR44 Gene

Aliases for WDR44 Gene

  • WD Repeat Domain 44 2 3 5
  • Rabphilin-11 3 4
  • WD Repeat-Containing Protein 44 3
  • RAB11BP 3
  • RPH11 3

External Ids for WDR44 Gene

Previous GeneCards Identifiers for WDR44 Gene

  • GC0XP117261
  • GC0XP117364
  • GC0XP117480
  • GC0XP106974

Summaries for WDR44 Gene

Entrez Gene Summary for WDR44 Gene

  • This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for WDR44 Gene

WDR44 (WD Repeat Domain 44) is a Protein Coding gene. Among its related pathways are Ectoderm Differentiation. An important paralog of this gene is AHI1.

UniProtKB/Swiss-Prot for WDR44 Gene

  • Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).

Gene Wiki entry for WDR44 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR44 Gene

Genomics for WDR44 Gene

Regulatory Elements for WDR44 Gene

Enhancers for WDR44 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG118773 0.9 ENCODE 10.3 +427.8 427848 1.5 PKNOX1 ZFP64 FOS ZNF202 ZNF680 ZNF654 ZBTB11 ZNF426 REST ZNF623 ENSG00000239182 ZCCHC12 KIAA1210 WDR44 IL13RA1 ENSG00000250995
GH0XG118155 0.7 ENCODE 10.4 -189.3 -189333 2.9 SOX13 FOXA2 ZBTB40 TEAD3 NCOR1 HNF4G CREM ZNF652 GATAD2A SOX5 WDR44 RPL12P43 PIR45613
GH0XG118344 1.1 ENCODE 5.9 +0.7 722 4.4 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF263 SP3 MIR1277 WDR44
GH0XG118329 0.8 ENCODE 6.7 -16.8 -16811 0.5 HDAC1 LEF1 TAL1 ETV1 TCF12 FOXM1 NCOR1 TRIM24 SMARCE1 RNF2 MIR1277 WDR44 PIR62368
GH0XG118349 0.9 Ensembl ENCODE 5.6 +4.4 4429 1.8 SRF ZNF843 FOSL1 ZNF121 PRDM6 ATF3 IKZF1 RELB PRDM10 IKZF2 MIR1277 WDR44
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR44 on UCSC Golden Path with GeneCards custom track

Promoters for WDR44 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000248250 728 3600 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ZNF263

Genomic Location for WDR44 Gene

Chromosome:
X
Start:
118,346,073 bp from pter
End:
118,449,961 bp from pter
Size:
103,889 bases
Orientation:
Plus strand

Genomic View for WDR44 Gene

Genes around WDR44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR44 Gene

Proteins for WDR44 Gene

  • Protein details for WDR44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JSH3-WDR44_HUMAN
    Recommended name:
    WD repeat-containing protein 44
    Protein Accession:
    Q5JSH3
    Secondary Accessions:
    • B4DSE9
    • F8W913
    • Q0JS52
    • Q0JTF3
    • Q5JSH2
    • Q6ZSC1
    • Q7Z365
    • Q7Z3P6
    • Q8NAU8
    • Q8NHU5
    • Q9NUV4

    Protein attributes for WDR44 Gene

    Size:
    913 amino acids
    Molecular mass:
    101366 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity).
    SequenceCaution:
    • Sequence=BAA92015.1; Type=Frameshift; Positions=792; Evidence={ECO:0000305}; Sequence=BAC03799.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR44 Gene

Post-translational modifications for WDR44 Gene

  • Ubiquitination at Lys518 and isoforms=2, 3, 4756
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR44 Gene

No data available for DME Specific Peptides for WDR44 Gene

Domains & Families for WDR44 Gene

Gene Families for WDR44 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR44: view

No data available for UniProtKB/Swiss-Prot for WDR44 Gene

Function for WDR44 Gene

Molecular function for WDR44 Gene

UniProtKB/Swiss-Prot Function:
Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).
genes like me logo Genes that share phenotypes with WDR44: view

Animal Model Products

CRISPR Products

miRNA for WDR44 Gene

miRTarBase miRNAs that target WDR44

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR44 Gene

Localization for WDR44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR44 Gene

Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR44 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
endosome 5
nucleus 3

Gene Ontology (GO) - Cellular Components for WDR44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol IEA --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with WDR44: view

Pathways & Interactions for WDR44 Gene

SuperPathways for WDR44 Gene

SuperPathway Contained pathways
1 Ectoderm Differentiation
genes like me logo Genes that share pathways with WDR44: view

Pathways by source for WDR44 Gene

1 BioSystems pathway for WDR44 Gene

Gene Ontology (GO) - Biological Process for WDR44 Gene

None

No data available for SIGNOR curated interactions for WDR44 Gene

Drugs & Compounds for WDR44 Gene

(1) Drugs for WDR44 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with WDR44: view

Transcripts for WDR44 Gene

Unigene Clusters for WDR44 Gene

WD repeat domain 44:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR44 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for WDR44 Gene

GeneLoc Exon Structure for
WDR44
ECgene alternative splicing isoforms for
WDR44

Expression for WDR44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR44 Gene

Protein differential expression in normal tissues from HIPED for WDR44 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.1), Platelet (9.0), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR44 Gene



Protein tissue co-expression partners for WDR44 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR44 Gene:

WDR44

SOURCE GeneReport for Unigene cluster for WDR44 Gene:

Hs.98510

Evidence on tissue expression from TISSUES for WDR44 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
  • Liver(4.2)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with WDR44: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR44 Gene

Orthologs for WDR44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR44 34
  • 99.72 (n)
cow
(Bos Taurus)
Mammalia WDR44 34 35
  • 93.2 (n)
dog
(Canis familiaris)
Mammalia WDR44 34 35
  • 92.91 (n)
rat
(Rattus norvegicus)
Mammalia Wdr44 34
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Wdr44 34 16 35
  • 90.53 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR44 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR44 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR44 34 35
  • 76.53 (n)
lizard
(Anolis carolinensis)
Reptilia WDR44 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr44 34
  • 71.34 (n)
Str.2992 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24056 34
zebrafish
(Danio rerio)
Actinopterygii WDR44 35
  • 67 (a)
OneToOne
LOC569045 34
  • 66.13 (n)
wufj86d11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5696 34
fruit fly
(Drosophila melanogaster)
Insecta CG34133 35
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sym-4 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 17 (a)
ManyToMany
DGR2 35
  • 15 (a)
ManyToMany
-- 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2709 35
  • 52 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2529 34
Species where no ortholog for WDR44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR44 Gene

ENSEMBL:
Gene Tree for WDR44 (if available)
TreeFam:
Gene Tree for WDR44 (if available)

Paralogs for WDR44 Gene

Paralogs for WDR44 Gene

(1) SIMAP similar genes for WDR44 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR44: view

Variants for WDR44 Gene

Sequence variations from dbSNP and Humsavar for WDR44 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs483352750 Uncertain significance 118,432,880(+) TTGAT(C/T)TTTCA reference, missense
rs1000027671 -- 118,361,623(+) TGGTG(C/G)TGCAT intron-variant
rs1000039224 -- 118,413,048(+) GAGTA(A/G)TATTC intron-variant
rs1000093580 -- 118,398,966(+) GTGTT(A/G)CACCA intron-variant
rs1000106684 -- 118,419,670(+) TCTGA(A/G)TAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR44 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV gain 19592680
nsv522227 CNV gain 19592680

Variation tolerance for WDR44 Gene

Residual Variation Intolerance Score: 33.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR44

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR44 Gene

Disorders for WDR44 Gene

Relevant External Links for WDR44

Genetic Association Database (GAD)
WDR44
Human Genome Epidemiology (HuGE) Navigator
WDR44
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR44

No disorders were found for WDR44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR44 Gene

Publications for WDR44 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for WDR44 Gene

Sources for WDR44 Gene

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