WDR44 Gene
protein-coding GIFtS : 51
GCID: GC0X P117480
WD repeat domain 44
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Aliasesfor WDR44 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases WD Repeat Domain 44 1 2 Rabphilin-113 RAB11BP1 2 WD Repeat-Containing Protein 442 RPH111 2 Rabphilin-113 DKFZp686L201451
Export aliases for WDR44 gene to outside databases Previous GC identifers: GC0XP117261 GC0XP117364 GC0XP106974
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Summariesfor WDR44 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for WDR44 : This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.(provided by RefSeq, May 2010) UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3 Function : Downstream effector for RAB11. May be involved in vesicle recycling (By similarity)Gene Wiki entry for WDR44
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Genomic Viewsfor WDR44 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011786.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the WDR44 gene promoter: Brachyury MEF-2 MyoD E47 MEF-2A E2F E2F-1 aMEF-2 Pax-4a Other transcription factors Search SABiosciences Chromatin IP Primers for WDR44 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat WDR44
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq24 Ensembl cytogenetic band: Xq24 HGNC cytogenetic band: Xq24 WDR44 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP117480: view genomic region
(about GC identifiers )
Start:
117,480,036 bp from pter
End:
117,583,924 bp from pter
Size:
103,889 bases
Orientation:
plus strand
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Proteinsfor WDR44 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3 (See
protein sequence )Recommended Name: WD repeat-containing protein 44 Size : 913 amino acids; 101366 Da
Subunit : Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho smallG proteins (By similarity)
Subcellular location : Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus,trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia (By similarity)
Sequence caution : Sequence=BAA92015.1; Type=Frameshift; Positions=792; Sequence=BAC03799.1; Type=Erroneous initiation;
Secondary accessions : Q0JS52 Q0JTF3 Q5JSH2 Q6ZSC1 Q7Z365 Q7Z3P6 Q8NAU8 Q8NHU5 Q9NUV4Alternative splicing : 3 isoforms : Q5JSH3-1 Q5JSH3-2 Q5JSH3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for WDR44: NX_Q5JSH3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5JSH3 WDR44 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001171894.1 NP_001171895.1 NP_061918.3 ENSEMBL proteins: ENSP00000254029 ENSP00000360890 ENSP00000360914 ENSP00000360887 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
WDR44 for ontologies About GeneDecksing WDR44 Antibody Products: Assay Products for WDR44:
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Protein
Domains / Familiesfor WDR44 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
WDR44 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q5JSH3 ProtoNet protein and cluster: Q5JSH3
UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3 Similarity : Contains 7 WD repeats
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Functionfor WDR44 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: WDR44_HUMAN, Q5JSH3 Function : Downstream effector for RAB11. May be involved in vesicle recycling (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): WDR44 (NM_019045 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDR44
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR44
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0017137 Rab GTPase binding
-- --
WDR44 for ontologies About GeneDecksing Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Wdr44) :
WDR44 for phenotypes About GeneDecksing
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Pathways & Interactionsfor WDR44 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR44 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/29 Interacting proteins for WDR44 (Q5JSH3 3 ENSP00000254029 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 29 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0030334 regulation of cell migration
-- --
WDR44 for ontologies About GeneDecksing
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Drugs & Compoundsfor WDR44 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for WDR44 1 HMDB Compound for WDR44 About this table Search CenterWatch for drugs/clinical trials and news about WDR44
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Transcriptsfor WDR44 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for WDR44 gene (3 alternative transcripts): NM_001184965.1 NM_001184966.1 NM_019045.4 Unigene Cluster for WDR44:
WD repeat domain 44 Hs.98510 [show with all ESTs ] Unigene Representative Sequence: NM_019045 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000254029 (uc004eqn.3 uc004eqo.3 uc010nqi.3 ) ENST00000371825 ENST00000493448 ENST00000371848 ENST00000371822 (uc011mtr.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): WDR44 (NM_019045 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR44 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDR44
Additional cDNA sequence: AK001978.1 AK092077.1 AK127556.1 AK299711.1 AK304432.1 AL833605.1 AL834210.1 BC013924.1 BC028697.2 BX537578.1 BX538087.1 BX648150.1
7 DOTS entries : DT.107510 DT.100727267
DT.91758262 DT.433975 DT.100021894 DT.121324138 DT.99947417 24/81 AceView cDNA sequences (see all 81 ):
BX538087 BX648150 BC013924 AA767059 AW148385 AW139472 BQ921584 AI627346 AK092077 BX280516 AL833605 AA426298 BC028697 NM_019045 AW611931 AI074635 AA259020 AK127556 BX537578 AK001978 AA344633 CF890924 AW387904 CB051775 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR44 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 SP1 :                                                 -     SP2 :                                           -       -     SP3 :                                                     SP4 :                       -   -                             SP5 :   -                                                  
ECgene alternative splicing isoforms for WDR44
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Expression for WDR44 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section WDR44 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGTTGATGG
About this image WDR44 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See WDR44 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for WDR44 SOURCE GeneReport for Unigene cluster: Hs.98510 SABiosciences Custom PCR Arrays for WDR44 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WDR44Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat WDR44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WDR44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WDR44 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR44
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Orthologsfor WDR44 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR44 gene from 9/28 species (see all 28 ) About this table
ENSEMBL Gene Tree for WDR44 (if available)TreeFam Gene Tree for WDR44 (if available)
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Paralogsfor WDR44 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for WDR44 gene AHI1 2 1 SIMAP similar gene for WDR44 using alignment to 4 protein entries: WDR44_HUMAN (see all proteins ):DKFZp761M142
WDR44 for paralogs About GeneDecksing
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Genomic Variantsfor WDR44 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for WDR44 (117480036 - 117583924 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for WDR44 2 CNVs : 83696 96912 Locus Specific Mutation Databases (LSDB): WDR44
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WDR44
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Disorders
/ Diseasesfor WDR44 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
WDR44 for disorders About GeneDecksing 2 diseases for WDR44 : About MalaCards pharyngitis neuronitis Human Genome Epidemiology (HuGE) Navigator: WDR44 (1 document)Export disorders for WDR44 gene to outside databases
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Publicationsfor WDR44 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for WDR44 gene, integrated from 9 sources (see all 30 ): (articles sorted by number of sources associating them with WDR44) Utopia : connect your pdf to the dynamic world of online information
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 1 , 2 Beausoleil S.A.... Gygi S.P. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883) 1 Kristensen A.R....Foster L.J. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011)
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External Searches for WDR44 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing WDR44 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing WDR44 gene
(According to HUGE )
About This Section --
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Specialized Databases showing WDR44 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for WDR44 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for WDR44 gene: Search GeneIP for patents involving WDR44 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor WDR44 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for WDR44 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for WDR44 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for WDR44 OriGene Protein Over-expression Lysate for WDR44 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for WDR44 OriGene 3'-UTR Clone for WDR44 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for WDR44 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for WDR44 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for WDR44 OriGene Custom Protein Services for WDR44 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR44 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing WDR44 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat WDR44 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat WDR44 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat WDR44 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat WDR44
Search Tocris compounds for WDR44
WDR44 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR44
Search ThermoFisher Antibodies for WDR44
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat WDR44
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Aliases for WDR44
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Expression for WDR44
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