WDR43 Gene
protein-coding GIFtS: 50
GCID: GC02P029117
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|
WD repeat domain 43
| |
Aliases
for WDR43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| WD Repeat Domain 431 2 | | NET121 2 | | UTP51 2 | | KIAA00071 3 | | UTP5, Small Subunit (SSU) Processome Component, Homolog2 | | WD Repeat-Containing Protein 432 |
| External Ids: | HGNC: 289451 | Entrez Gene: 231602 | Ensembl: ENSG000001638117 | UniProtKB: Q150613 | | ORGUL members: | |
|---|
| NONCODE:n342404 | |
Export aliases for WDR43 gene to outside databasesPrevious GC identifers: GC02P029004 GC02P028946 GC02P028859
|---|
Summaries
for WDR43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for WDR43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR43 gene promoter:
NF-1 NF-1/L Lmo2 LCR-F1 AP-2gamma c-Myb AP-2beta Pax-4a AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.2 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.3WDR43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P029117: view genomic region
(about GC identifiers)
Start:
|
29,117,509 bp from pter |
End:
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29,171,088 bp from pter |
Size:
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53,580 bases |
Orientation:
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plus strand |
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Proteins
for WDR43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR43_HUMAN, Q15061 (See
protein sequence)Recommended Name: WD repeat-containing protein 43 Size: 677 amino acids; 74891 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAA05499.1; Type=Erroneous initiation; Sequence=BAA05499.1; Type=Frameshift; Positions=614,617;
Secondary accessions: Q15395 Q92577Explore the universe of human proteins at neXtProt for WDR43: NX_Q15061
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15061
WDR43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055946.1
ENSEMBL proteins: ENSP00000384302 ENSP00000390363 ENSP00000415355 ENSP00000296126 ENSP00000406083
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- |
WDR43 for ontologies About GeneDecksing
WDR43 Antibody Products:
Assay Products for WDR43: |
Protein
Domains /
Families
for WDR43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR43 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15061ProtoNet protein and cluster: Q15061 1 Blocks protein family: IPB012979 Protein of unknown function NUC189
UniProtKB/Swiss-Prot: WDR43_HUMAN, Q15061Similarity: Belongs to the UTP5 familySimilarity: Contains 6 WD repeats |
Function
for WDR43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR43 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: WDR43 (NM_015131) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR43 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR43 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR43 |
4 GenomeRNAi human phenotypes for WDR43:
|
Pathways & Interactions
for WDR43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ribosome biogenesis in eukaryotes | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for WDR43):
WDR43 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR43
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5 Interacting proteins for WDR43 (Q150613 ENSP000003843024) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for WDR43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR43
Search CenterWatch for drugs/clinical trials and news about WDR43
|
Transcripts
for WDR43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR43 gene: NM_015131.1 Unigene Cluster for WDR43: WD repeat domain 43 Hs.709228 [show with all ESTs]Unigene Representative Sequence: NM_0151316 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000407426(uc002rmo.2) ENST00000434238 ENST00000440983 ENST00000296126
ENST00000466067 ENST00000446643
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR43 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR43 (NM_015131) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR43 |
Additional cDNA sequence: AK000836.1 BC024234.1 BC033206.1 D26488.1 D87716.1 11 DOTS entries: DT.454182 DT.100791444 DT.100791439 DT.114715 DT.120987788 DT.86852439 DT.100637825 DT.92426323 DT.95301867 DT.92426326 DT.95141641 24/142 AceView cDNA sequences (see all 142): AA315159 T29045 AW009935 BG036013 AA865370 CB133931 CR612320 CR618449 BE408569 BU188794 AW593733 BI061925 BX475682 AL532397 BG760680 AW999532 BM473523 BQ053985 BG826406 BX475447 BX432011 BM756514 BM754426 CN482190
GeneLoc Exon Structure
|
Expression
for WDR43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCTCACC
About this image
See WDR43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR43
SOURCE GeneReport for Unigene cluster: Hs.709228
SABiosciences Custom PCR Arrays for WDR43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat WDR43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR43 |
Orthologs
for WDR43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for WDR43 gene from 10/32 species (see all 32) About this table
ENSEMBL Gene Tree for WDR43 (if available)
TreeFam Gene Tree for WDR43 (if available) |
Paralogs
for WDR43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for WDR43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR43 (29117509 - 29171088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for WDR43
1 CNV: 9401
1 Indel: 26654 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR43 |
|
Disorders
/ Diseases
for WDR43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for WDR43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR43 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with WDR43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
- Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. (PubMed id 17699751)1, 3 Prieto J.L. and McStay B. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Prediction of the coding sequences of unidentified hu man genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell li ne KG-1 (supplement). (PubMed id 7584028)1, 3 Nomura N....Tabata S. (1994)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
|
External Searches for WDR43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR43 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing WDR43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR43 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR43 gene:
Search GeneIP for patents involving WDR43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | Search Tocris compounds for WDR43 |
| |  |  |  |  | | | | |
 |
 |
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 | | | WDR43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR43 |
|  |  |  | | | | ThermoFisher Antibody for WDR43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR43 |
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Last full update: 19 Mar 2013 -
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