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WDR43 Gene

protein-coding GIFtS: 46

GC02P028946

WD repeat domain 43
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
KIAA0007 ^¹, ³

Descriptions
WD repeat domain 43 ^²

External Ids
HGNC: 28945¹
Entrez Gene: 23160²
UniProtKB: Q15061³
Ensembl: ENSG00000163811⁷

Search outside databases for aliases for WDR43 gene

Previous GC identifer: GC02P029004

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2 Ensembl cytogenetic band: 2p23.2 HGNC cytogenetic band: 2p23.3

WDR43 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P028946: (about GC identifiers)

Start:	28,946,737 bp from pter
End:	29,024,592 bp from pter
Size:	77,856 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR43_HUMAN, Q15061 (See protein sequence)

Recommended Name: WD repeat-containing protein 43

Size: 677 amino acids; 74891 Da

Subcellular location: Nucleus, nucleolus

Sequence caution: Sequence=BAA05499.1; Type=Frameshift; Positions=614, 617;

Secondary accessions: Q15395 Q92577

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055946.1

ENSEMBL proteins:

ENSP00000296126 ENSP00000384302

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for WDR43:

	Browse Antibodies Central at Invitrogen
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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	Search Novus for antibodies for WDR43

Assays for WDR43:

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	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15061

ProtoNet protein and cluster: Q15061

1 Blocks protein family: IPB012979 Protein of unknown function NUC189

UniProtKB/Swiss-Prot: WDR43_HUMAN, Q15061

Similarity: Belongs to the UTP5 family

Similarity: Contains 6 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR43)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): XM_940941

Applied Biosystems Silencer® siRNAs for WDR43

Sigma-Aldrich siRNA for WDR43

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015131
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015131
untagged cDNA clones in CMV expression vector (see all 2): NM_015131

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015131

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR43

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR43)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): XM_940941

Sigma-Aldrich siRNA for WDR43

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015131

REFSEQ mRNAs for WDR43 gene:

NM_015131.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015131

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015131
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015131
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_015131

Additional cDNA sequence:

AK000836.1 BC024234.1 BC033206.1 CR612320.1 CR618449.1 D26488.1 D87716.1

11 DOTS entries:

DT.454182 DT.100791444 DT.100791439 DT.114715 DT.120987788 DT.86852439 DT.100637825 DT.92426323

DT.92426326 DT.95141641 DT.95301867

24/142 AceView cDNA sequences (see all 142 ):

CR612320 CB133931 BQ053985 BI061925 AW593733 AW999532 BG760680 CR618449

AW009935 BM473523 AA865370 BU188794 BX475682 BE408569 BG036013 AL532397

AA315159 T29045 W19428 BX475447 AW949331 BX432011 D57375 BG826406

highest scoring ESTs for WDR43:

D26488 AA044399 AA580434 AI457359 AI961936 AL516198 AL532396 AL581865 AW088023 AW118220

Unigene Cluster for WDR43:

WD repeat domain 43

Hs.709228 [show with all ESTs]

Unigene Representative Sequence: NM_015131

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000296126 ENST00000407426

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR43 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR43

¹ / ² / ³

3 probe-sets matching WDR43 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38250_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D26488	1.00	0.87	0.94	1
214662_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D26488	1.00	0.87	0.94	1
214662_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAGCTCACC

SOURCE GeneReport for Unigene cluster: Hs.709228
Expression variation in blood from EXPOLDB for WDR43

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR43 gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR43¹	--	WD repeat domain 43	90.68(n) 93.2(a)	475713 XM_532920.2 XP_532920.2
chimpanzee (Pan troglodytes)	WDR43¹	--	WD repeat domain 43	99.56(n) 99.7(a)	459122 XM_515377.2 XP_515377.2
cow (Bos taurus)	WDR43¹	--	WD repeat domain 43	91.07(n) 92.31(a)	538915 XM_583609.3 XP_583609.3
rat (Rattus norvegicus)	Wdr43¹	--	WD repeat domain 43	84.97(n) 87.98(a)	362703 XM_001059356.1 XP_001059356.1
mouse (Mus musculus)	Wdr43^{1, 5}	17⁵	WD repeat domain 43^{1, 5}	85.59(n)¹ 87.52(a)¹	72515¹ XM_001005092.2¹ XP_001005092.2¹ AA098431⁵ AA980618⁵ (see all 18)

About this table Species with no ortholog for WDR43

ENSEMBL Gene Tree for WDR43

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/351 NCBI SNPs in WDR43 are shown (see all 351 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 117)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6753809^1,2	A,C,F,H	29024681(+)	`CTGGCA/GTTAAA`	1	--	ng3¹		4		EU EA WA	420
	rs4665437^1,2	A,C,F,H	29024885(+)	`CTTTAC/TTGGTA`	1	--	ng3¹		15		NA EU EA WA	1394
	rs12477538^1,2	C,F,H	29024792(+)	`TTCTTC/TATGCA`	1	--	ng3¹		4		EU EA WA	412
	rs1131880^1,2	F,H,O	29024180(+)	`TTTATG/CTATGT`	1	--	ut3¹		5		MN EU EA WA	600
	rs11890131^1,2	A,C,H	29024324(+)	`TCTAAG/AAAAGG`	1	--	ut3¹		4		EU EA WA	420
--	rs4666142^1,2	A,C	29025048(+)	`TTAGAA/GTATTT`	1	--	ng3¹		0	--	--	--	--
	rs12465505^1,2	F,H	29024589(+)	`TACCCA/TGTGCT`	1	--	ng3¹		4		EU EA WA	416
	rs11680458^1,2	F,H	29024127(+)	`GCAGTG/TTTAGG`	1	--	ut3¹		4		EU EA WA	420
	rs12464717^1,2	H	29024406(+)	`TTAATA/CCCAAT`	1	--	ut3¹		4		EU EA WA	420
	rs13397763^1,2	H	29024338(+)	`GGGCAG/AATGGA`	1	--	ut3¹		3		EU EA	282

About this table

HapMap Linkage Disequilibrium images for WDR43 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/11 PubMed articles for WDR43 gene (see all 11 ):

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{2, 3, 4} Nomura N....Tabata S. (1994)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{3, 4} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Functional proteomic analysis of human nucleolus. (PubMed id 12429849)^{3, 4} Scherl A.... Diaz J.-J. (2002)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PubMed id 7584028)^{2, 3} Nomura N....Tabata S. (1994)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 23160	HGNC: 28945	AceView: WDR43	Ensembl:ENSG00000163811	euGenes: HUgn23160
ECgene: WDR43	H-InvDB: WDR43

(According to HUGE)
About This Section

HUGE: KIAA0007

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR43
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR43:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR43-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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WDR43 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for WDR43

Summaries
for WDR43

Genomic Location
for WDR43

Proteins
for WDR43

Protein Domains/
Families
for WDR43

Gene Function
for WDR43

Pathways & Interactions
for WDR43

Drugs & Compounds
for WDR43

Transcripts
for WDR43

Expression
for WDR43

Orthologs
for WDR43

Paralogs
for WDR43

SNPs/Variants
for WDR43

Disorders & Mutations
for WDR43

Medical News
for WDR43

Publications
for WDR43

Search for WDR43

Genome Databases showing WDR43

Other Databases showing WDR43

Specialized Databases showing WDR43

Licensable Technologies
for WDR43

Services
for WDR43

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR43 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor WDR43

Summariesfor WDR43

Genomic Locationfor WDR43

Proteinsfor WDR43

Protein Domains/Familiesfor WDR43

Gene Functionfor WDR43

Pathways & Interactionsfor WDR43

Drugs & Compoundsfor WDR43

Transcriptsfor WDR43

Expression for WDR43

Orthologsfor WDR43

Paralogsfor WDR43

SNPs/Variantsfor WDR43

Disorders & Mutationsfor WDR43

Medical Newsfor WDR43

Publicationsfor WDR43

Search for WDR43

Genome Databases showing WDR43

Other Databases showing WDR43

Specialized Databases showing WDR43

Licensable Technologiesfor WDR43

Servicesfor WDR43

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR43

Summaries
for WDR43

Genomic Location
for WDR43

Proteins
for WDR43

Protein Domains/
Families
for WDR43

Gene Function
for WDR43

Pathways & Interactions
for WDR43

Drugs & Compounds
for WDR43

Transcripts
for WDR43

Expression
for WDR43

Orthologs
for WDR43

Paralogs
for WDR43

SNPs/Variants
for WDR43

Disorders & Mutations
for WDR43

Medical News
for WDR43

Publications
for WDR43

Licensable Technologies
for WDR43

Services
for WDR43