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WDR42C Gene

protein-coding   GIFtS: 29

GC0XP027674
WD repeat domain 42C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
WD repeat domain 42C 2
External Ids
HGNC: 318111
Entrez Gene: 3474422
UniProtKB: P0C7V83
Search outside databases for aliases for WDR42C gene

Previous GC identifer: GC0XP027524

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR42C gene  

Entrez Gene cytogenetic band: Xp21.3   HGNC cytogenetic band: Xp22.11

WDR42C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP027674:     (about GC identifiers)

Start:
27,662,480 bp from pter
End:
27,677,442 bp from pter
Size:
14,963 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD42C_HUMAN, P0C7V8 (See protein sequence)
Recommended Name: WD repeat-containing protein 42C  
Size: 602 amino acids; 67911 Da

REFSEQ proteins: NP_001130005.1  
Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR42C: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR42C

Assays for WDR42C: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR42C for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P0C7V8

ProtoNet protein and cluster: P0C7V8

UniProtKB/Swiss-Prot: WD42C_HUMAN, P0C7V8
Similarity: Belongs to the WD repeat WDR42 family
Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR42C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Applied Biosystems Silencer® siRNAs for WDR42C

              Sigma-Aldrich siRNA for WDR42C  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001136533
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001136533
                                 untagged cDNA clone in CMV expression vector: NM_001136533 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001136533

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR42C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR42C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
                Browse Origene for 29mer shRNA kit in GFP-retroviral vector

              Sigma-Aldrich siRNA for WDR42C  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001136533  

REFSEQ mRNAs for WDR42C gene: 

NM_001136533.1   


              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001136533
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001136533
                                 untagged cDNA clone in CMV expression vector: NM_001136533 

Additional cDNA sequence: 

AK057304.1 BC157859.1 

7 DOTS entries:

DT.95229612  DT.121278135  DT.121278137  DT.40127100  DT.91669686  DT.405152  DT.121278133 

5 AceView cDNA sequences:

AA401668 AA863490 BI857493 BU177378 AA398888 

highest scoring ESTs for WDR42C:

BE843926 BE938604 BI857493 BU177378 BU568503 AA401668 AA398888 AA863490 XM_293354 

Unigene Cluster for WDR42C:

WD repeat domain 42C
Hs.127840  [show with all ESTs]
Unigene Representative Sequence: NM_001136533


GeneLoc Exon Structure

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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WDR42C expression in normal and diseased human tissues

1 / 3Data from (Publications) and GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.127840
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR42C gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
WDR42C1   -- WD repeat domain 42C 81.25(n)
77.17(a)
491793  XM_548912.2  XP_548912.2 
chimpanzee
(Pan troglodytes)
WDR42C1   -- WD repeat domain 42C 95.29(n)
94.42(a)
465551  XM_520989.2  XP_520989.2 
thale cress
(Arabidopsis thaliana)
AT4G351401   -- transducin family protein / WD-40 repeat family protein 49.29(n)
45.01(a)
829666  NM_119680.4  NP_195240.2 
rice
(Oryza sativa)
Os10g05445001   -- hypothetical protein 47.24(n)
39.57(a)
4349273  NM_001071736.1  NP_001065201.1 
About this table        Species with no ortholog for WDR42C
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/65 NCBI SNPs in WDR42C are shown (see all 65 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 15)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs59268931,2
C,F,H27669481(+) CTTAGG/AAGACC 1 E/G mis14Minor allele frequency- A:0.47EU EA WA 358
rs59268951,2
C,F,H27675966(+) TCTTCA/GCCATT 1 T/A mis112Minor allele frequency- N:0.00EU EA WA NA 840
rs173483571,2
C,F,H27677048(+) CTTTAC/TGCCTC 1 -- ut3112Minor allele frequency- T:0.22NA EU EA WA 923
--
rs59714471,2
A,C27660989(+) ctcccC/Gggttc 1 -- ng510--------
--
rs59268881,2
F,H27661199(+) catggG/Tttccc 1 -- ng514Minor allele frequency- T:0.38EU EA WA 402
rs59264911,2
C27669475(+) CCATGC/GCTTAG 1 G/A mis10--------
--
rs169879801,2
F27677356(+) GCCGCA/TCACAC 1 -- ut313Minor allele frequency- T:0.01NA 142
--
rs126879641,2
H27660574(+) GATTAG/ACTTCC 1 -- ng514Minor allele frequency- A:0.00EU EA WA 418
--
rs18113851,2
C27676010(+) GTGGTA/TACAAG 1 V/V syn11Minor allele frequency- T:0.00MN 184
rs59268941,2
A,C,F,H27673699(+) ATTTAC/TCTTGC 1 -- int14Minor allele frequency- T:0.45EU EA WA 412
About this table

HapMap Linkage Disequilibrium images for WDR42C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for WDR42C gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 347442 HGNC: 31811 AceView: WDR42C.1 euGenes: HUgn347442 ECgene: WDR42C
H-InvDB: WDR42C
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR42C:
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR42C Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
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