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WDR42B Gene

protein-coding   GIFtS: 34

GC0XM027906
WD repeat domain 42B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ46244 2
OTTHUMP00000023096 2
Descriptions
WD repeat domain 42B 2
External Ids
HGNC: 318101
Entrez Gene: 1394252
UniProtKB: A6NGE43
Ensembl: ENSG000001891867
Search outside databases for aliases for WDR42B gene

Previous GC identifer: GC0XM027755

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR42B gene  

Entrez Gene cytogenetic band: Xp21.3   Ensembl cytogenetic band:  Xp21.3   HGNC cytogenetic band: Xp22.11

WDR42B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM027906:     (about GC identifiers)

Start:
27,906,031 bp from pter
End:
27,909,487 bp from pter
Size:
3,457 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011757.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD42B_HUMAN, A6NGE4 (See protein sequence)
Recommended Name: WD repeat-containing protein 42B  
Size: 600 amino acids; 67373 Da
Secondary accessions: B3KXX1

REFSEQ proteins: NP_001017930.1  

ENSEMBL proteins: 
ENSP00000355257 


Human Recombinant Proteins 
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Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR42B: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR42B

Assays for WDR42B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR42B for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A6NGE4

ProtoNet protein and cluster: A6NGE4

UniProtKB/Swiss-Prot: WD42B_HUMAN, A6NGE4
Similarity: Belongs to the WD repeat WDR42 family
Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR42B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_066690

              Applied Biosystems Silencer® siRNAs for WDR42B

              Sigma-Aldrich siRNA for WDR42B  
                     Sigma-Aldrich shRNA for WDR42B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017930
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017930
                                 untagged cDNA clone in CMV expression vector: NM_001017930 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001017930

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR42B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR42B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_066690

              Sigma-Aldrich siRNA for WDR42B  
                     Sigma-Aldrich shRNA for WDR42B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001017930  

REFSEQ mRNAs for WDR42B gene: 

NM_001017930.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001017930  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017930
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017930
                                 untagged cDNA clone in CMV expression vector: NM_001017930 

Additional cDNA sequence: AK128123.1 

1 DOTS entry:

DT.101961017 

2 AceView cDNA sequences:

AK128123 BU570685 

highest scoring ESTs for WDR42B:

AK128123 BU570685 DB076199 NM_001017930 DB340574 

Unigene Cluster for WDR42B:

WD repeat domain 42B
Hs.447365  [show with all ESTs]
Unigene Representative Sequence: AK128123


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000329763  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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WDR42B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR42B

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GATTGCTTAA

SOURCE GeneReport for Unigene cluster: Hs.447365
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR42B gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
WDR42B1   -- WD repeat domain 42B 98.87(n)
97.79(a)
473546  XM_528917.2  XP_528917.2 
About this table        Species with no ortholog for WDR42B

ENSEMBL Gene Tree for WDR42B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR42B gene
WDR42A2  WDR222  WDTC12  IQWD12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/18 NCBI SNPs in WDR42B are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 23)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs120145861,2
A,C,F,H27909504(+) ACCAAT/CCCGAT 1 -- ng314Minor allele frequency- C:0.01EU EA WA 418
rs120115891,2
C,F,H27911109(+) gcatgG/Attctt 1 -- ng314Minor allele frequency- A:0.01EU EA WA 420
rs123885571,2
C,H27907728(+) GAACCG/AAAGCA 1 W/R mis1 ese34Minor allele frequency- A:0.00EU EA WA 418
--
rs66537891,2
H27905537(+) ACATTT/CTCCCC 1 -- ng514Minor allele frequency- C:0.00EU EA WA 410
rs66537901,2
H27906943(+) TGTTTT/CCTTTC 1 -- ut314Minor allele frequency- C:0.00EU EA WA 418
--
rs559249911,2
--27907787(+) CCTGCC/TTGTTC 1 K/R mis10--------
--
rs59018781,2
--27907301(+) AAAAA-/AGTAAT 1 -- ut310--------
rs617351811,2
--27908745(+) CAGTCC/TGGTGC 2 R/R R/G syn1 mis10--------
--
rs617351821,2
--27908946(+) GGAAAA/GCCACT 2 I/L I/F mis10--------
--
rs735427021,2
--27910150(+) AGCTTA/GAAGAC 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for WDR42B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for WDR42B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 139425 HGNC: 31810 AceView: WDR42B Ensembl:ENSG00000189186 euGenes: HUgn139425
ECgene: WDR42B H-InvDB: WDR42B
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR42B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR42B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR42B Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for WDR42B Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for WDR42B

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