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WDR42A Gene

protein-coding   GIFtS: 47

GC01M158452
WD repeat domain 42A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp781G1096 2
FLJ35857 1, 2
H326 1, 2, 3
MGC117276 2
MGC118891 2
MGC99640 2
OTTHUMP00000029883 2
OTTHUMP00000029884 2
OTTHUMP00000029885 2
Descriptions
WD repeat domain 42A 2
External Ids
HGNC: 248911
Entrez Gene: 507172
UniProtKB: Q5TAQ93
Ensembl: ENSG000001327167
Search outside databases for aliases for WDR42A gene

Previous GC identifer: GC01M156998

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR42A:
The function of this gene has not yet been determined. Several alternatively spliced transcript
variants of this gene have been described, but the full-length nature of these variants has not
been determined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR42A gene  

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q22-q23

WDR42A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158452:     (about GC identifiers)

Start:
158,452,129 bp from pter
End:
158,498,915 bp from pter
Size:
46,787 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WD42A_HUMAN, Q5TAQ9 (See protein sequence)
Recommended Name: WD repeat-containing protein 42A  
Size: 597 amino acids; 66852 Da
Sequence caution: Sequence=AAA16607.1; Type=Frameshift; Positions=117, 123;
Secondary accessions: Q12839 Q4QQI6 Q53F14 Q66K50 Q68CS7 Q96E00
Alternative splicing: 2 isoforms:  Q5TAQ9-1   Q5TAQ9-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_056541.2  

    ENSEMBL proteins: 
    ENSP00000357052 ENSP00000357053 ENSP00000318227 ENSP00000384118 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (WDR42A)
    Human Recombinant Proteins from Abnova (WDR42A)
                  OriGene Purified Recombinant Human Protein: WDR42A 


    Antibodies for WDR42A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for WDR42A
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (WDR42A), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (WDR42A)
    Novus Biologicals Antibodies for WDR42A

    Assays for WDR42A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR019782 WD40_repeat_2
     IPR019775 WD40_repeat_CS
     IPR019781 WD40_repeat_sg
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_region


       GeneDecks  WDR42A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5TAQ9

    ProtoNet protein and cluster: Q5TAQ9

    UniProtKB/Swiss-Prot: WD42A_HUMAN, Q5TAQ9
    Similarity: Belongs to the WD repeat WDR42 family
    Similarity: Contains 7 WD repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR42A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WDR42A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015726

                  Applied Biosystems Silencer® siRNAs for WDR42A

                  Sigma-Aldrich siRNA for WDR42A  
                         Sigma-Aldrich shRNA for WDR42A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for WDR42A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015726
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015726
                                     untagged cDNA clones in CMV expression vector (see all 2): BC013107 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015726

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for WDR42A (Q5TAQ92) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997502MINT-67377
    --Q8WUW92MINT-66096
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for WDR42A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (WDR42A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (WDR42A)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015726

                  Sigma-Aldrich siRNA for WDR42A  
                         Sigma-Aldrich shRNA for WDR42A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015726  

    REFSEQ mRNAs for WDR42A gene: 

    NM_015726.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015726  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_015726
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_015726
                                     untagged cDNA clones in CMV expression vector (see all 2): BC013107 

    Additional cDNA sequence: 

    AK093176.1 AK223475.1 AK303188.1 AK312690.1 BC013107.1 BC080597.1 BC098245.1 BC098271.1 
    BC099709.1 BC099846.1 BC111063.1 CR598549.1 CR749801.1 U06631.1 

    24/34 DOTS entries (see all 34 ):

    DT.92051950  DT.100717839  DT.100832270  DT.92437277  DT.95116105  DT.121410933  DT.75169508  DT.92437269 
    DT.100743160  DT.121410755  DT.87015963  DT.451997  DT.70104362  DT.100797018  DT.100797017  DT.101982429 
    DT.121410772  DT.92437273  DT.40263756  DT.95359769  DT.95150538  DT.95150536  DT.121410851  DT.121410890 

    8 AceView cDNA sequences:

    N45176 BF439213 H59420 BF060954 N39328 AA937174 H02445 H60073 

    highest scoring ESTs for WDR42A:

    U06631 AL603610 AU132964 BC013107 BM469886 BM563341 BM835506 BQ067484 BQ428597 BX491791 

    Unigene Cluster for WDR42A:

    WD repeat domain 42A
    Hs.632447  [show with all ESTs]
    Unigene Representative Sequence: NM_015726


    GeneLoc Exon Structure

    5/29 Alternative Splicing Database (ASD) splice patterns (SP) for WDR42A (see all 29 )

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                -     -     -     -     -     -     -                       -                                                               
    SP4:                                -     -     -     -     -     -     -     -                 -                                                               
    SP5:                                            -     -     -     -     -                       -                                                               

    ExUns: 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                                                  -     -     -     -     -     -                 -                           
    SP2:                                                  -           -           -     -                                             
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for WDR42A

    4 Ensembl transcripts including schematic representations:
    ENST00000368073  ENST00000368074  ENST00000326837  ENST00000407642  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    WDR42A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for WDR42A

    1 / 2 / 3

    16 probe-sets matching WDR42A gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    79828_at2, 3 U95-D 1 1.00 1.00 0.84 0.69 AI858304 0.40 1.00 0.76 1

    39823_at2, 3 U95-A 1 1.00 1.00 0.54 1.61 U06631 1.00 0.90 0.95 1

    50161_at2, 3 U95-B 1 0.94 1.00 0.83 0.72 N39328 0.60 1.00 0.82 1

    232339_at2, 3 U133-B 1 1.00 1.00 -- -- AK026213 0.20 1.00 0.72 1

    233637_at2, 3 U133-B 1 1.00 1.00 -- -- AU146915 0.40 1.00 0.76 1

    216885_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK026481 0.40 1.00 0.76 1

    202249_s_at2, 3 U133-A 1 1.00 1.00 -- -- AU146233 0.40 1.00 0.76 1

    202250_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015726 0.60 0.83 0.73 1

    238340_at2, 3 U133-B 1 1.00 1.00 -- -- AL134577 0.60 0.83 0.73 1

    232339_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1554049_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    233637_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    216885_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202249_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202250_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    238340_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CACTCTGGAA

    SOURCE GeneReport for Unigene cluster: Hs.632447
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for WDR42A gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    WDR42A1   -- WD repeat domain 42A 93.23(n)
    98.66(a)
    478971  XM_536129.2  XP_536129.2 
    chimpanzee
    (Pan troglodytes)
    WDR42A1   -- WD repeat domain 42A 99.77(n)
    100(a)
    457434  XM_513922.2  XP_513922.2 
    cow
    (Bos taurus)
    WDR42A1   -- WD repeat domain 42A 94.02(n)
    98.82(a)
    510316  XM_866189.2  XP_871282.1 
    rat
    (Rattus norvegicus)
    Wdr42a1   -- WD repeat domain 42A 92.16(n)
    97.97(a)
    364050  NM_001014231.1  NP_001014253.1 
    mouse
    (Mus musculus)
    Wdr42a1, 5 1 (93.70 cM)5
    WD repeat domain 42A1, 5 91.28(n)1
    96.43(a)1
    981931  NM_153555.11  NP_705783.11 
     AA4088775  AA4331205  (see all 36)
    About this table        Species with no ortholog for WDR42A

    ENSEMBL Gene Tree for WDR42A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for WDR42A gene
    WDR42B2  WDR222  WDTC12  IQWD12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/268 NCBI SNPs in WDR42A are shown (see all 268 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 94)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs9474951,2
    A,C,F,H,O158499300(-) CAAAGC/TCCTGA 1 -- ng3113Minor allele frequency- T:0.49NA PA MN EA EU WA 2514
    rs9474961,2
    A,C,F,H,O158499130(-) TGTTTT/AGAGTA 1 -- ng318Minor allele frequency- A:0.36MN NA EU EA WA 744
    rs11328811,2
    C,F,H158452919(-) GGGTTG/AGGAAA 1 -- ut318Minor allele frequency- A:0.05MN NA EU EA WA 746
    rs168316061,2
    C,F,H158452497(+) ACTCAG/ATGACC 1 -- ut31 ese37Minor allele frequency- A:0.03NA EU EA WA 560
    rs67038801,2
    C,F,H158500344(+) TAGATC/ATTTAC 1 -- ng314Minor allele frequency- A:0.36EU EA WA 418
    rs168316191,2
    F,H158453425(+) AATAAG/AGTGGA 1 -- ut317Minor allele frequency- A:0.03NA EU EA WA 562
    --
    rs66885861,2
    A,C158499969(+) aattgA/Cttgaa 1 -- ng310--------
    rs168317181,2
    F,H158500521(+) CAGCTA/GTACTA 1 -- ng317Minor allele frequency- G:0.05NA EU EA WA 560
    rs45359961,2
    H158452762(+) CAAAGT/AACCAC 1 -- ut314Minor allele frequency- A:0.00EU EA WA 418
    --
    rs112653571,2
    C158453797(+) TCCATA/GGAGCC 1 -- ut31 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for WDR42A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/12 PubMed articles for WDR42A gene (see all 12 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 50717 HGNC: 24891 AceView: WDR42A Ensembl:ENSG00000132716 euGenes: HUgn50717
    ECgene: WDR42A H-InvDB: WDR42A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR42A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for WDR42A Antibodies for WDR42A
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     Search Tocris compounds for WDR42A




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