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WDR40C Gene

protein-coding   GIFtS: 37

GC0XM125126
WD repeat domain 40C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA1892-like 2
OTTHUMP00000023977 2
Descriptions
WD repeat domain 40B-like 2
WD repeat domain 40C 2
External Ids
HGNC: 329501
Entrez Gene: 3405782
UniProtKB: Q5VW003
Ensembl: ENSG000001983547
Search outside databases for aliases for WDR40C gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR40C gene  

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

WDR40C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM125126:     (about GC identifiers)

Start:
125,126,195 bp from pter
End:
125,127,615 bp from pter
Size:
1,421 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011786.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD40C_HUMAN, Q5VW00 (See protein sequence)
Recommended Name: WD repeat-containing protein 40C  
Size: 463 amino acids; 50803 Da
Secondary accessions: B2RN42

REFSEQ proteins: NP_001013650.1  

ENSEMBL proteins: 
ENSP00000353128 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR40C: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR40C

Assays for WDR40C: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR40C for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5VW00

ProtoNet protein and cluster: Q5VW00

UniProtKB/Swiss-Prot: WD40C_HUMAN, Q5VW00
Similarity: Belongs to the WD repeat WDR40 family
Similarity: Contains 4 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR40C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293387

              Applied Biosystems Silencer® siRNAs for WDR40C

              Sigma-Aldrich siRNA for WDR40C  
                     Sigma-Aldrich shRNA for WDR40C  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001013628
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001013628
                                 untagged cDNA clone in CMV expression vector: NM_001013628 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001013628

1 MGI phenotypic allele for Wdr40c (no phenotypes)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR40C

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR40C)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_293387

              Sigma-Aldrich siRNA for WDR40C  
                     Sigma-Aldrich shRNA for WDR40C  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001013628  

REFSEQ mRNAs for WDR40C gene: 

NM_001013628.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001013628  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001013628
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001013628
                                 untagged cDNA clone in CMV expression vector: NM_001013628 

Additional cDNA sequence: 

BC136673.1 BC136674.1 

2 DOTS entries:

DT.40124153  DT.40259363 

1 AceView cDNA sequence:

BM546996 

highest scoring ESTs for WDR40C:

BM546996 BY798820 NM_001013628 R12204 H24437 

Unigene Cluster for WDR40C:

WD repeat domain 40C
Hs.496728  [show with all ESTs]
Unigene Representative Sequence: BC136674


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000360028  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR40C expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR40C

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: GGAACTACGC

SOURCE GeneReport for Unigene cluster: Hs.496728
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR40C gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
WDR40C1   -- WD repeat domain 40C 87.9(n)
87.9(a)
492114  XM_549235.2  XP_549235.2 
chimpanzee
(Pan troglodytes)
WDR40C1   -- WD repeat domain 40C 99.26(n)
99.68(a)
473770  XM_529143.2  XP_529143.2 
cow
(Bos taurus)
WDR40C1   -- WD repeat domain 40C 80.59(n)
73.81(a)
614685  XM_866263.2  XP_871356.2 
rat
(Rattus norvegicus)
Wdr40c1   -- WD repeat domain 40C 79.99(n)
82.94(a)
298159  XM_233093.4  XP_233093.4 
mouse
(Mus musculus)
Wdr40c1, 5 X5
WD repeat domain 40C1, 5 80.06(n)1
83.15(a)1
2454031  NM_175539.31  NP_780748.11 
 AK0373335  AK0764365  (see all 8)
About this table        Species with no ortholog for WDR40C

ENSEMBL Gene Tree for WDR40C
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR40C gene
WDR40B2  WDR40A2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/13 NCBI SNPs in WDR40C are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 19)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs101264521,2
C125127148(+) CCCTGG/TTGGGC 1 H/Q mis1 ese30--------
rs120149371,2
A,C,F,H125126869(+) TATACG/TGGGAG 1 P/P syn1 ese34Minor allele frequency- T:0.47EU EA WA 418
rs37615521,2
A,C,F,H125126371(+) CTGCCA/GCAGGC 1 C/C syn1 ese34Minor allele frequency- G:0.45EU EA WA 416
--
rs66381491,2
--125128063(+) GGAGGC/TTGGAA 1 -- ng310--------
--
rs59779341,2
--125128053(+) CGCGCA/GGGGTG 1 -- ng310--------
rs617389301,2
--125126390(+) GCTTCA/GTCCCT 2 R/T R/M mis10--------
--
rs59779331,2
--125126164(+) AGGTAA/CACCTG 1 -- ng510--------
--
rs617518711,2
--125126631(+) GTACAC/GGGACA 1 L/V mis10--------
rs617433551,2
--125126816(+) GGTTGC/TTGCTG 2 T/N T/S mis10--------
--
rs617431141,2
--125126512(+) TGCTGC/TTAGAA 2 Y/X non10--------
About this table

HapMap Linkage Disequilibrium images for WDR40C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for WDR40C gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 340578 HGNC: 32950 AceView: LOC340578.1 Ensembl:ENSG00000198354 euGenes: HUgn340578
ECgene: WDR40C H-InvDB: WDR40C
(According to HUGE)
About This Section

HUGE: KIAA1892-like
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR40C:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR40C-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR40C Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for WDR40C Browse small molecules at Sigma-Aldrich
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