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WDR40B Gene

protein-coding   GIFtS: 37

GC0XM125511
WD repeat domain 40B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
A130007F10Rik 2
KIAA1892-like 2
KIAA1892L 1, 2
OTTHUMP00000023979 2
Descriptions
WD repeat domain 40B 2
External Ids
HGNC: 293951
Entrez Gene: 1391702
UniProtKB: Q5VU923
Ensembl: ENSG000001988897
Search outside databases for aliases for WDR40B gene

Previous GC identifers: GC0XM124389 GC0XM125408

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for WDR40B:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR40B gene  

Entrez Gene cytogenetic band: Xq25   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25

WDR40B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM125511:     (about GC identifiers)

Start:
125,511,050 bp from pter
End:
125,514,515 bp from pter
Size:
3,466 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011786.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD40B_HUMAN, Q5VU92 (See protein sequence)
Recommended Name: WD repeat-containing protein 40B  
Size: 463 amino acids; 51201 Da
Secondary accessions: Q8IYK3

REFSEQ proteins: NP_848565.2  

ENSEMBL proteins: 
ENSP00000360167 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: WDR40B 


Antibodies for WDR40B: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR40B

Assays for WDR40B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR40B for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q5VU92

ProtoNet protein and cluster: Q5VU92

UniProtKB/Swiss-Prot: WD40B_HUMAN, Q5VU92
Similarity: Belongs to the WD repeat WDR40 family
Similarity: Contains 4 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR40B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178470

              Applied Biosystems Silencer® siRNAs for WDR40B

              Sigma-Aldrich siRNA for WDR40B  
                     Sigma-Aldrich shRNA for WDR40B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178470
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178470
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_178470 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_178470

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR40B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR40B)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178470

              Sigma-Aldrich siRNA for WDR40B  
                     Sigma-Aldrich shRNA for WDR40B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_178470  

REFSEQ mRNAs for WDR40B gene: 

NM_178470.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_178470  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178470
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178470
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_178470 

Additional cDNA sequence: BC035674.1 

1 DOTS entry:

DT.106864 

11 AceView cDNA sequences:

NM_178470 AA885034 AI758399 BC035674 AA983785 BM563914 AA883751 BX100533 
AI139786 AA723819 AW572906 

highest scoring ESTs for WDR40B:

AI139786 BC035674 BM563914 AA723819 AA883751 AA885034 AA983785 AI758399 AW572906 BX100533 

Unigene Cluster for WDR40B:

WD repeat domain 40B
Hs.120403  [show with all ESTs]
Unigene Representative Sequence: BC035674


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000371126  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR40B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR40B

1 / 2 / 3

3 probe-sets matching WDR40B gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
81468_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AI139786 0.80 1.00 0.91 1

238205_at2, 3 U133-B 1 1.00 1.00 -- -- AW572906 0.60 1.00 0.82 1

238205_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  WDR40B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.120403
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR40B gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
rat
(Rattus norvegicus)
Wdr40b1   -- WD repeat domain 40B 76.24(n)
71.71(a)
313296  XM_233080.3  XP_233080.3 
mouse
(Mus musculus)
Wdr40b1   -- WD repeat domain 40B 75.95(n)
71.49(a)
245404  NM_178739.4  NP_848854.2 
About this table        Species with no ortholog for WDR40B

ENSEMBL Gene Tree for WDR40B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR40B gene
WDR40C2  WDR40A2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/14 NCBI SNPs in WDR40B are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 17)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs39238771,2
A,C,F,H125515700(+) GAGGGT/CGTGGG 1 -- ng31 tfbs34Minor allele frequency- C:0.45EU EA WA 412
rs59760121,2
A,C,F,H125516005(+) TGGTAA/GTAGTG 1 -- ng314Minor allele frequency- G:0.11EU EA WA 418
--
rs110957221,2
A,C125514217(+) CGGCGC/TCCGCC 1 D/G mis10--------
rs120102051,2
H125510709(+) ATTGCC/GTACAA 1 -- ng514Minor allele frequency- G:0.00EU EA WA 418
--
rs66354931,2
A125510838(+) aaaaaA/Ccaaaa 1 -- ng510--------
--
rs626067951,2
--125515315(+) CTGTTG/TTCAGT 1 -- ng310--------
--
rs351020861,2
--125515778(+) CTTCT-/CCCCCA 1 -- ng310--------
--
rs66355091,2
--125515876(+) CCATAG/TGTCCT 1 -- ng310--------
--
rs78898131,2
--125515358(+) TTGGGA/CCAGGG 1 -- ng310--------
--
rs358633191,2
--125513350(+) ATTAT-/CCCCGG 1 D/G fra10--------
About this table

HapMap Linkage Disequilibrium images for WDR40B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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  --

(Possibly Related Articles in Doctor's Guide)
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  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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3 PubMed articles for WDR40B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 139170 HGNC: 29395 AceView: WDR40B Ensembl:ENSG00000198889 euGenes: HUgn139170
ECgene: WDR40B H-InvDB: WDR40B
(According to HUGE)
About This Section

HUGE: KIAA1892L KIAA1892-like
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR40B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR40B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR40B Browse antibodies at Sigma-Aldrich
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 Lentivirus-delivered shRNAs for WDR40B Browse small molecules at Sigma-Aldrich
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