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WDR40A Gene

protein-coding GIFtS: 41

GC09M034078

WD repeat domain 40A
(Previous name: KIAA1892 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: KIAA1892)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZP434O125 ^¹
DKFZp434O125 ^²
KIAA1892 ^¹, ², ³
MGC1058 ^¹, ²
OTTHUMP00000000477 ^²
OTTHUMP00000000478 ^²
OTTHUMP00000000479 ^²
OTTHUMP00000021241 ^²
TCC52 ^², ³

Descriptions
Centrosome-related protein TCC52 ^³
Testis cancer centrosome-related protein ^³
WD repeat domain 40A ^²
centrosome related protein ^²

External Ids
HGNC: 19911¹
Entrez Gene: 25853²
UniProtKB: Q5T6F0³
Ensembl: ENSG00000198876⁷

Search outside databases for aliases for WDR40A gene

Previous GC identifer: GC09M034077

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR40A:

This gene was identified by isolating cDNA from a size-fractionated library derived from brain in

an attempt to characterize genes encoding large proteins. The function of the protein encoded by

this gene has not yet been determined. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR40A gene

Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2

WDR40A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M034078: (about GC identifiers)

Start:	34,076,386 bp from pter
End:	34,124,183 bp from pter
Size:	47,798 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WD40A_HUMAN, Q5T6F0 (See protein sequence)

Recommended Name: WD repeat-containing protein 40A

Size: 453 amino acids; 50517 Da

Subcellular location: Cytoplasm. Centrosome

Sequence caution: Sequence=BAA91106.1; Type=Frameshift; Positions=27; Sequence=CAI15300.1;

Type=Erroneous gene model prediction; Sequence=CAI15302.1; Type=Erroneous gene model prediction;

Secondary accessions: A8KA70 Q5T6E9 Q5T6F1 Q6P3V0 Q7L4F8 Q96PZ5 Q9NXA9 Q9UFJ1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056212.1

ENSEMBL proteins:

ENSP00000380186 ENSP00000380187 ENSP00000355114

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR40A:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR40A
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for WDR40A

Assays for WDR40A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5T6F0

ProtoNet protein and cluster: Q5T6F0

UniProtKB/Swiss-Prot: WD40A_HUMAN, Q5T6F0

Similarity: Belongs to the WD repeat WDR40 family

Similarity: Contains 4 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR40A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015397

Applied Biosystems Silencer® siRNAs for WDR40A

Sigma-Aldrich siRNA for WDR40A

Sigma-Aldrich shRNA for WDR40A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015397
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015397
untagged cDNA clone in CMV expression vector: NM_015397

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015397

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR40A

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR40A)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015397

Sigma-Aldrich siRNA for WDR40A

Sigma-Aldrich shRNA for WDR40A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015397

REFSEQ mRNAs for WDR40A gene:

NM_015397.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015397

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015397
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015397
                                 untagged cDNA clone in CMV expression vector: NM_015397

Additional cDNA sequence:

AB067479.1 AF131771.1 AK000354.1 AK292935.1 AL117646.1 BC008893.2 BC063823.1 CR622703.1

DQ518909.1

10 DOTS entries:

DT.456182 DT.100757767 DT.100708325 DT.92057874 DT.121203710 DT.91719845 DT.100815044 DT.440635

DT.95356002 DT.97774544

24/322 AceView cDNA sequences (see all 322 ):

AA233436 BQ214433 BM978464 BP374864 BQ219845 R38902 AA676565 AW731634

CB850845 BU625360 BP370296 BM772534 AI825215 NM_015397 CR622703 BI966162

AA676535 BI834589 AW594242 AI431598 BU621649 AA740245 AA383244 AI698685

highest scoring ESTs for WDR40A:

AA158330 AA306049 AB067479 AK000354 AL040481 AL550886 AL597026 AL597030 AL597031 AL597107

Unigene Clusters for WDR40A:

WD repeat domain 40A

Hs.493750 [show with all ESTs], Hs.716472 [show with all ESTs]

Unigene Representative Sequences: CR591883, NM_015397

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000396989 ENST00000396990 ENST00000361264

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR40A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR40A

¹ / ² / ³

3 probe-sets matching WDR40A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55760_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AL040481	0.80	1.00	0.91	1
224789_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL555107	0.40	1.00	0.76	1
224789_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCAAAGATAA

SOURCE GeneReport for Unigene clusters: Hs.493750 Hs.716472
UniProtKB/Swiss-Prot: WD40A_HUMAN, Q5T6F0
Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted
expression in normal testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR40A gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR40A¹	--	WD repeat domain 40A	94.19(n) 99.34(a)	481584 XM_860580.1 XP_865673.1
chimpanzee (Pan troglodytes)	WDR40A¹	--	WD repeat domain 40A	96.98(n) 96.25(a)	465052 XM_520537.2 XP_520537.2
cow (Bos taurus)	WDR40A¹	--	WD repeat domain 40A	93.89(n) 98.01(a)	525161 XM_864671.2 XP_869764.1
mouse (Mus musculus)	Wdr40a^{1, 5}	4⁵	WD repeat domain 40A^{1, 5}	91.61(n)¹ 98.45(a)¹	68970¹ NM_026893.2¹ NP_081169.2¹ AA420338⁵ AI840445⁵ (see all 20)
chicken (Gallus gallus)	WDR40A¹	--	WD repeat domain 40A	80.5(n) 91.27(a)	427396 NM_001031444.1 NP_001026615.1

About this table Species with no ortholog for WDR40A

ENSEMBL Gene Tree for WDR40A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR40A gene

WDR40C² WDR40B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/243 NCBI SNPs in WDR40A are shown (see all 243 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1052656^1,2	A,C,F,H	34077360(-)	`CCCCCA/GTGGCT`	1	--	ut3¹ ese³		12		MN NA EU EA WA	1164
	rs10971942^1,2	A,C,F,H	34117763(+)	`TGGTCA/CCTTCA`	1	--	ng3¹		6		EU EA WA NA	596
	rs10971903^1,2	A,C,F,H	34077246(+)	`ACACAC/TAGATA`	1	--	ut3¹ ese³		8		EU EA WA	838
	rs2297609^1,2	C,F,H	34116788(-)	`CGCCCC/ATCTCG`	1	--	ng3¹		5		EA EU WA	1902
--	rs11557154^1,2	C,F,H	34097505(-)	`AGACCG/AGGAGC`	1	Q/R	mis¹		8		EA WA NA EU	776
--	rs12376123^1,2	C	34077630(+)	`GCTGGA/GTCACT`	1	--	ut3¹		3		NA	142
--	rs10971943^1,2	A	34118427(+)	`TTTTTC/TTTTTT`	1	--	ng3¹ trp³		0	--	--	--	--
--	rs1378^1,2	C,F	34097504(-)	`GACCGG/AGAGCC`	1	R/R	syn¹ ese³		2		MN NA	248
	rs4879743^1,2	A,C,F,H	34098324(+)	`ATGAAC/TGAGAG`	1	--	int¹		8		EU EA WA	838
	rs10758240^1,2	A,C,F,H	34088110(+)	`TAGACC/TACTCA`	1	--	int¹		11		EU EA WA NA	920

About this table

HapMap Linkage Disequilibrium images for WDR40A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/12 PubMed articles for WDR40A gene (see all 12 ):

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{2, 3, 4} Nagase T....Ohara O. (2001)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{2, 3} Yu W....Gibbs R.A. (1997)
Novel centrosome protein, TCC52, is a cancer-testis antigen. (PubMed id 18957058)³ Li S....He D. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)³ Barrios-Rodiles M....Wrana J.L. (2005)
Transcriptome analysis of human gastric cancer. (PubMed id 16341674)³ Oh J.H....Kim N.S. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)⁴ Humphray S.J.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25853	HGNC: 19911	AceView: WDR40A	Ensembl:ENSG00000198876	euGenes: HUgn25853
ECgene: WDR40A	H-InvDB: WDR40A

(According to HUGE)
About This Section

HUGE: KIAA1892

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR40A
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR40A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR40A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR40A		Antibodies for WDR40A
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	Recombinant & Natural Proteins

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WDR40A Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for WDR40A

Summaries
for WDR40A

Genomic Location
for WDR40A

Proteins
for WDR40A

Protein Domains/
Families
for WDR40A

Gene Function
for WDR40A

Pathways & Interactions
for WDR40A

Drugs & Compounds
for WDR40A

Transcripts
for WDR40A

Expression
for WDR40A

Orthologs
for WDR40A

Paralogs
for WDR40A

SNPs/Variants
for WDR40A

Disorders & Mutations
for WDR40A

Medical News
for WDR40A

Publications
for WDR40A

Search for WDR40A

Genome Databases showing WDR40A

Other Databases showing WDR40A

Specialized Databases showing WDR40A

Licensable Technologies
for WDR40A

Services
for WDR40A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR40A Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor WDR40A

Summariesfor WDR40A

Genomic Locationfor WDR40A

Proteinsfor WDR40A

Protein Domains/Familiesfor WDR40A

Gene Functionfor WDR40A

Pathways & Interactionsfor WDR40A

Drugs & Compoundsfor WDR40A

Transcriptsfor WDR40A

Expression for WDR40A

Orthologsfor WDR40A

Paralogsfor WDR40A

SNPs/Variantsfor WDR40A

Disorders & Mutationsfor WDR40A

Medical Newsfor WDR40A

Publicationsfor WDR40A

Search for WDR40A

Genome Databases showing WDR40A

Other Databases showing WDR40A

Specialized Databases showing WDR40A

Licensable Technologiesfor WDR40A

Servicesfor WDR40A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR40A

Summaries
for WDR40A

Genomic Location
for WDR40A

Proteins
for WDR40A

Protein Domains/
Families
for WDR40A

Gene Function
for WDR40A

Pathways & Interactions
for WDR40A

Drugs & Compounds
for WDR40A

Transcripts
for WDR40A

Expression
for WDR40A

Orthologs
for WDR40A

Paralogs
for WDR40A

SNPs/Variants
for WDR40A

Disorders & Mutations
for WDR40A

Medical News
for WDR40A

Publications
for WDR40A

Licensable Technologies
for WDR40A

Services
for WDR40A