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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR4 Gene

protein-coding   GIFtS: 53
GCID: GC21M044263

WD Repeat Domain 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
WD Repeat Domain 42 11     TRMT822
WD Repeat-Containing Protein 42 3     TRM82 TRNA Methyltransferase 82 Homolog2
TRM82 TRNA Methyltransferase 82 Homolog (S. Cerevisiae)1     TRNA (Guanine-N(7)-)-Methyltransferase Subunit WDR42
TRM822     

External Ids:    HGNC: 127561   Entrez Gene: 107852   Ensembl: ENSG000001601937   OMIM: 6059245   UniProtKB: P570813   

Export aliases for WDR4 gene to outside databases

Previous GC identifers: GC21M040810 GC21M043157 GC21M043136 GC21M029678


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR4 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is
excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other
disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for WDR4 Gene: 
WDR4 (WD repeat domain 4) is a protein-coding gene. Diseases associated with WDR4 include nonsyndromic deafness, and down syndrome. GO annotations related to this gene include protein binding and tRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is
required to stabilize and induce conformational change of the catalytic subunit

Gene Wiki entry for WDR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR4 gene promoter:
         ATF-2   c-Ets-1   E47   HEN1   E2F-1   E2F   Hand1   ZIC2/Zic2   c-Jun   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR4 promoter sequence

   Search SABiosciences Chromatin IP Primers for WDR4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
WDR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR4 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M044263:   GeneLoc Nature:405,311-319
Start:
44,263,204 bp from pter       29,816,661 bp from centromere
End:
44,299,678 bp from pter 29,846,963 bp from centromere
Size:
36,475 bases 30,303 bases
Orientation:
minus strand minus strand

genomic clones: KB51A8 KB1405B7


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081 (See protein sequence)
Recommended Name: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4  
Size: 412 amino acids; 45490 Da
Subunit: Forms a complex with METTL1
Subcellular location: Nucleus
Secondary accessions: A8KA58 B2RCA3 B4DNQ7 D3DSK3 Q9BVM5 Q9HCR3
Alternative splicing: 3 isoforms:  P57081-1   P57081-2   P57081-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR4: NX_P57081

Explore proteomics data for WDR4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P57081

  • WDR4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR4 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001247403.1  NP_001247404.1  NP_001247405.1  NP_001247406.1  NP_061139.2  NP_387510.1  

    ENSEMBL proteins: 
     ENSP00000328671   ENSP00000381266  

    Human Recombinant Protein Products for WDR4: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDR4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA16780588
    GO:0005737cytoplasm IDA--

    WDR4 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for WDR4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P57081

    ProtoNet protein and cluster: P57081

    UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
    Similarity: Belongs to the WD repeat TRM82 family
    Similarity: Contains 4 WD repeats


    WDR4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR4_HUMAN, P57081
    Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is
    required to stabilize and induce conformational change of the catalytic subunit

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15861136
    GO:0008176contributes to tRNA (guanine-N7-)-methyltransferase activity IDA12403464
         
    WDR4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for WDR4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR4:
    hsa-miR-518f*
    SwitchGear 3'UTR luciferase reporter plasmidWDR4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
    Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for WDR4 (P570812, 3 ENSP000003286714) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL1Q9UBP63, ENSP000003144414I2D: score=6 STRING: ENSP00000314441
    TERF1ENSP000002766034STRING: ENSP00000276603
    TERF2ENSP000002549424STRING: ENSP00000254942
    --Q53FS93, 2MINT-67787 I2D: score=1 
    --Q53FS93, 2MINT-67787 I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006400tRNA modification IDA15861136
    GO:0036265RNA (guanine-N7)-methylation IDA12403464

    WDR4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR4

    Search CenterWatch for drugs/clinical trials and news about WDR4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR4 gene (6 alternative transcripts): 
    NM_001260474.1  NM_001260475.1  NM_001260476.1  NM_001260477.1  NM_018669.5  NM_033661.4  

    Unigene Cluster for WDR4:

    WD repeat domain 4
    Hs.248815  [show with all ESTs]
    Unigene Representative Sequence: NM_001260477
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330317(uc002zci.3) ENST00000492742 ENST00000398208(uc002zck.1 uc010gpg.1 uc010gph.1 uc011aew.1)
    ENST00000476326(uc002zcl.1) ENST00000479429 ENST00000463902 ENST00000470658

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat WDR4
    1 QIAGEN miScript miRNA Assays for microRNA that regulate WDR4:
    hsa-miR-518f*
    SwitchGear 3'UTR luciferase reporter plasmidWDR4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for WDR4
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    Clone
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    OriGene clones in human, mouse for WDR4 (see all 13)
    OriGene ORF clones in mouse, rat for WDR4
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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR4 (NM_001164267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for WDR4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR4
    Sirion Biotech Customized lentivirus for stable overexpression of WDR4 
                         Customized lentivirus expression plasmids for stable overexpression of WDR4 
    Primer
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    OriGene qPCR primer pairs and template standards for WDR4
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR4

    Additional mRNA sequence: 

    AJ243912.1 AJ243913.1 AK056343.1 AK292923.1 AK298015.1 AK315008.1 BC001074.2 BC006341.2 
    BC018866.2 NR_048535.1 

    9 DOTS entries:

    DT.85101595  DT.100846297  DT.95360576  DT.40130265  DT.95360578  DT.97854856  DT.121131946  DT.100031099 
    DT.95340656 

    24/212 AceView cDNA sequences (see all 212):

    CB113244 BM471674 BM905262 BI908255 NM_001001503 BU741849 NM_021075 CB140449 
    AW007204 AA776726 CR616335 BI829092 CR542190 CR613268 AA725824 CR593887 
    BF765237 BQ001645 AI609645 AI570479 BP336670 BM475614 AA877479 AA894770 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                    -     -                             -                                               -         
    SP2:              -     -     -                 -           -                                                         
    SP3:                    -     -                             -                                                         
    SP4:                                            -           -                                                         
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for WDR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGAAGAT
    WDR4 Expression
    About this image


    See WDR4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR4

    SOURCE GeneReport for Unigene cluster: Hs.248815
        SABiosciences Custom PCR Arrays for WDR4
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WDR4 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr41 , 5 WD repeat domain 41, 5 80.13(n)1
    75.67(a)1
      17 (16.56 cM)5
    577731  NM_021322.21  NP_067297.21 
     314943235 
    chicken
    (Gallus gallus)
    Aves WDR41 WD repeat domain 4 62.61(n)
    57.36(a)
      418540  XM_416749.3  XP_416749.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR46
    Uncharacterized protein
    53(a)
    1 ↔ 1
    3(137452796-137474857)
    African clawed frog
    (Xenopus laevis)
    Amphibia wdr4-prov2 WD repeat domain 4 76.21(n)    BC043907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005366371 tRNA (guanine-N(7)-)-methyltransferase subunit WDR4-like 53.62(n)
    49.14(a)
      100536637  XM_003199199.1  XP_003199247.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wuho6
    wuho
    25(a)
    1 ↔ 1
    X(6182156-6183595)
    worm
    (Caenorhabditis elegans)
    Secernentea Y102E9.26
    tRNA (guanine-N(7)-)-methyltransferase subunit wdr...
    22(a)
    1 ↔ 1
    III(6725787-6728058)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM82(YDR165W)4 Subunit of a tRNA methyltransferase complex composed more   --   4(784871-786205) 851743  NP_010449.1 


    ENSEMBL Gene Tree for WDR4 (if available)
    TreeFam Gene Tree for WDR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR4 gene

    WDR4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for WDR4
    PGOHUM00000240080 PGOHUM00000241560


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1250 SNPs in WDR4 are shown (see all 1250)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421877561,2
    C--29684482(+) GATCAC/GGCGGC 6 -- ds50010--------
    rs1461757481,2
    C--29684490(+) GGCGCA/GCACCT 6 -- ds50010--------
    rs732316861,2
    C,F--44262773(+) TACCCG/ACAAAG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs733667831,2
    C,F--44262819(+) CCAGCG/ATCCCG 1 -- ds50013Minor allele frequency- A:0.13WA CSA 122
    rs1404535511,2
    C--44262825(+) TCCCGC/TTGGGG 1 -- ds50010--------
    rs1889808121,2
    C--44262835(+) GTCTTC/TGGATG 1 -- ds50010--------
    rs1503945891,2
    C--44262912(+) CCTCCA/GGAGGG 1 -- ds50010--------
    rs563745351,2
    C,F--44263041(+) CTAAAT/ACATCC 1 -- ds50019Minor allele frequency- A:0.42NA WA CSA EA 369
    rs99744101,2
    C,F,A,H--44263084(+) GCTTAA/CAACAA 1 -- ds500119Minor allele frequency- C:0.37NS EA NA CSA WA 2346
    rs1381010841,2
    --44263158(+) TTAAAG/TGAACC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WDR4 (44263204 - 44299678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for WDR4 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2723577CNV Deletion23290073
    esv2666871CNV Deletion23128226
    esv2723579CNV Deletion23290073
    esv2723578CNV Deletion23290073
    esv2723576CNV Deletion23290073
    nsv834105CNV Loss17160897
    nsv913806CNV Loss21882294
    nsv913819CNV Loss21882294
    nsv913818CNV Loss21882294
    dgv4753n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): WDR4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605924    OMIM disorders: --

    2 diseases for WDR4:    About MalaCards
    nonsyndromic deafness    down syndrome


    WDR4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): WDR4

    Export disorders for WDR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with WDR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PubMed id 12403464)1, 2, 3, 9 Alexandrov A.... Phizicky E.M. (2002)
    2. Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. (PubMed id 10950928)1, 2, 9 Michaud J.... Scott H.S. (2000)
    3. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PubMed id 15861136)1, 2 Cartlidge R.A....Cohen P. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10785 HGNC: 12756 AceView: NDUFV3 Ensembl:ENSG00000160193 euGenes: HUgn10785
    ECgene: WDR4 H-InvDB: WDR4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR4 gene:
    Search GeneIP for patents involving WDR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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