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Aliases for WDR4 Gene

Aliases for WDR4 Gene

  • WD Repeat Domain 4 2 3 5
  • WD Repeat-Containing Protein 4 3 4
  • TRM82 TRNA Methyltransferase 82 Homolog (S. Cerevisiae) 2
  • TRNA (Guanine-N(7)-)-Methyltransferase Subunit WDR4 3
  • TRM82 TRNA Methyltransferase 82 Homolog 3
  • TRMT82 3
  • TRM82 3

External Ids for WDR4 Gene

Previous GeneCards Identifiers for WDR4 Gene

  • GC21M040810
  • GC21M043157
  • GC21M043136
  • GC21M044263
  • GC21M029678

Summaries for WDR4 Gene

Entrez Gene Summary for WDR4 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for WDR4 Gene

WDR4 (WD Repeat Domain 4) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include tRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for WDR4 Gene

  • Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Gene Wiki entry for WDR4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR4 Gene

Genomics for WDR4 Gene

Regulatory Elements for WDR4 Gene

Promoters for WDR4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around WDR4 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR4 Gene

42,843,080 bp from pter
42,879,589 bp from pter
36,510 bases
Minus strand

Genomic View for WDR4 Gene

Genes around WDR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR4 Gene

Proteins for WDR4 Gene

  • Protein details for WDR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
    Protein Accession:
    Secondary Accessions:
    • A8KA58
    • B2RCA3
    • B4DNQ7
    • D3DSK3
    • Q9BVM5
    • Q9HCR3

    Protein attributes for WDR4 Gene

    412 amino acids
    Molecular mass:
    45490 Da
    Quaternary structure:
    • Forms a heterodimer with the catalytic subunit METTL1.

    Alternative splice isoforms for WDR4 Gene


neXtProt entry for WDR4 Gene

Proteomics data for WDR4 Gene at MOPED

Post-translational modifications for WDR4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR4 Gene

Antibody Products

No data available for DME Specific Peptides for WDR4 Gene

Domains & Families for WDR4 Gene

Gene Families for WDR4 Gene

Protein Domains for WDR4 Gene

Suggested Antigen Peptide Sequences for WDR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat TRM82 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat TRM82 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR4: view

Function for WDR4 Gene

Molecular function for WDR4 Gene

UniProtKB/Swiss-Prot Function:
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
genes like me logo Genes that share phenotypes with WDR4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR4 Gene

Localization for WDR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR4 Gene

Subcellular locations from

Jensen Localization Image for WDR4 Gene COMPARTMENTS Subcellular localization image for WDR4 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for WDR4 Gene

Pathways & Interactions for WDR4 Gene

genes like me logo Genes that share pathways with WDR4: view

Pathways by source for WDR4 Gene

UniProtKB/Swiss-Prot P57081-WDR4_HUMAN

  • Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis.

Gene Ontology (GO) - Biological Process for WDR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification IDA,TAS 15861136
GO:0030488 tRNA methylation IEA --
genes like me logo Genes that share ontologies with WDR4: view

No data available for SIGNOR curated interactions for WDR4 Gene

Drugs & Compounds for WDR4 Gene

No Compound Related Data Available

Transcripts for WDR4 Gene

Unigene Clusters for WDR4 Gene

WD repeat domain 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP6: -

Relevant External Links for WDR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR4 Gene

mRNA expression in normal human tissues for WDR4 Gene

Protein differential expression in normal tissues from HIPED for WDR4 Gene

This gene is overexpressed in Lung (56.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR4 Gene

SOURCE GeneReport for Unigene cluster for WDR4 Gene Hs.248815

genes like me logo Genes that share expression patterns with WDR4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for WDR4 Gene

Orthologs for WDR4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR4 35
  • 81.46 (n)
  • 80 (a)
WDR4 36
  • 79 (a)
(Canis familiaris)
Mammalia WDR4 35
  • 83 (n)
  • 80.85 (a)
WDR4 36
  • 80 (a)
(Mus musculus)
Mammalia Wdr4 35
  • 79.92 (n)
  • 76.1 (a)
Wdr4 16
Wdr4 36
  • 68 (a)
(Pan troglodytes)
Mammalia WDR4 35
  • 98.86 (n)
  • 98.54 (a)
WDR4 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Wdr4 35
  • 79.87 (n)
  • 75.72 (a)
(Monodelphis domestica)
Mammalia WDR4 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia WDR4 36
  • 67 (a)
(Gallus gallus)
Aves WDR4 35
  • 62.43 (n)
  • 57.11 (a)
WDR4 36
  • 56 (a)
(Anolis carolinensis)
Reptilia WDR4 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4956 35
African clawed frog
(Xenopus laevis)
Amphibia wdr4-prov 35
(Danio rerio)
Actinopterygii LOC100536637 35
  • 53.14 (n)
  • 48.86 (a)
FP017279.3 36
  • 43 (a)
wdr4 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta wuho 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y102E9.2 36
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRM82 36
  • 20 (a)
TRM82 38
Species with no ortholog for WDR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR4 Gene

Gene Tree for WDR4 (if available)
Gene Tree for WDR4 (if available)

Paralogs for WDR4 Gene Pseudogenes for WDR4 Gene

genes like me logo Genes that share paralogs with WDR4: view

No data available for Paralogs for WDR4 Gene

Variants for WDR4 Gene

Sequence variations from dbSNP and Humsavar for WDR4 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2248490 - 42,873,634(+) CCAGA(C/G)TTGGA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs15736 - 42,853,748(-) GCACT(C/T)CTGTG nc-transcript-variant, reference, missense
rs6586250 - 42,850,119(+) GACTC(C/T)GGCGC nc-transcript-variant, reference, missense
rs466182 -- 42,856,379(+) TCTTG(C/G)TTTTA intron-variant
rs458708 -- 42,853,053(+) CAGAC(A/C)AGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR4 Gene

Variant ID Type Subtype PubMed ID
esv2666871 CNV Deletion 23128226
nsv913806 CNV Loss 21882294
nsv913812 CNV Gain 21882294
nsv913813 CNV Gain 21882294
dgv4753n71 CNV Loss 21882294
nsv913818 CNV Loss 21882294
nsv913819 CNV Loss 21882294
esv2723576 CNV Deletion 23290073
esv2723577 CNV Deletion 23290073
esv2723578 CNV Deletion 23290073
esv2723579 CNV Deletion 23290073
nsv913820 CNV Gain 21882294
nsv834105 CNV Loss 17160897

Variation tolerance for WDR4 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.03; 90.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR4 Gene

Disorders for WDR4 Gene

Relevant External Links for WDR4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for WDR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR4 Gene

Publications for WDR4 Gene

  1. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PMID: 12403464) Alexandrov A. … Phizicky E.M. (RNA 2002) 2 3 4 23 67
  2. Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. (PMID: 10950928) Michaud J. … Scott H.S. (Genomics 2000) 3 23
  3. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for WDR4 Gene

Sources for WDR4 Gene

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