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WDR4 Gene

protein-coding GIFtS: 59

GC21M043136

WD repeat domain 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase, and/or ⁹Nature:405,311-319 and CroW21)
About This Section

Aliases
TRM82 ^¹, ²

Descriptions
WD repeat domain 4 ^², 9
WD repeat domain 4 protein ^²
WD repeat-containing protein 4 ^², ³

External Ids
HGNC: 12756¹
Entrez Gene: 10785²
UniProtKB: P57081³
Ensembl: ENSG00000160193⁷

Search outside databases for aliases for WDR4 gene

Previous GC identifers: GC21M040810 GC21M043157

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR4:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved

regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which

may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are

involved in a variety of cellular processes, including cell cycle progression, signal

transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of

nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as

well as for the development of Down syndrome phenotypes. Two transcript variants encoding the same

protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081

Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the

complex, it is required to stabilize and induce conformational change of the catalytic subunit

Gene Wiki entry for WDR4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band: 21q22.3

WDR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

(about GC identifiers)

GC21M043136:	GeneLoc	Nature:405,311-319
Start:	43,136,273 bp from pter	29,816,661 bp from centromere
End:	43,172,747 bp from pter	29,846,963 bp from centromere
Size:	36,475 bases	30,303 bases
Orientation:	minus strand	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_030188.4

genomic clones:

KB51A8 KB1405B7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081 (See protein sequence)

Recommended Name: tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

Size: 412 amino acids; 45490 Da

Subunit: Forms a complex with METTL1

Subcellular location: Nucleus

Secondary accessions: A8KA58 B2RCA3 B4DNQ7 Q9BVM5 Q9HCR3

Alternative splicing: 3 isoforms: P57081-1 P57081-2 P57081-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_061139.2 NP_387510.1

ENSEMBL proteins:

ENSP00000328671 ENSP00000381266

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WDR4)
	Human Recombinant Proteins from Abnova (WDR4)

OriGene Purified Recombinant Human Protein: WDR4

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	IDA	16780588

About this table

Antibodies for WDR4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for WDR4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (WDR4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (WDR4)
	Novus Biologicals Antibodies for WDR4

Assays for WDR4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P57081

ProtoNet protein and cluster: P57081

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081

Similarity: Belongs to the WD repeat TRM82 family

Similarity: Contains 4 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WDR4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_033661

Applied Biosystems Silencer® siRNAs for WDR4

Sigma-Aldrich siRNA for WDR4

Sigma-Aldrich shRNA for WDR4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_018669
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_018669
untagged cDNA clones in CMV expression vector (see all 2): NM_018669

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018669

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081

Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the

complex, it is required to stabilize and induce conformational change of the catalytic subunit

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081

Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis

2 Interacting proteins for WDR4 (P57081² ENSP00000328671³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
METTL1	ENSP00000314441³	STRING (score=.966)
--	Q53FS9²	MINT-67787

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008033	tRNA processing	IEA	--
GO:0008150	biological_process	ND	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (WDR4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_033661

Sigma-Aldrich siRNA for WDR4

Sigma-Aldrich shRNA for WDR4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018669 NM_033661

REFSEQ mRNAs for WDR4 gene (2 alternative transcripts):

NM_018669.4 NM_033661.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018669 NM_033661

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_018669
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_018669
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018669

Additional cDNA sequence:

AJ243912.1 AJ243913.1 AK056343.1 AK092786.1 AK292923.1 AK298015.1 AK315008.1 BC001074.2

BC006341.2 BC018866.2

12 DOTS entries:

DT.85101595 DT.100846297 DT.95360576 DT.436160 DT.40130265 DT.95360578 DT.112419 DT.97854856

DT.121131946 DT.100031099 DT.95340656 DT.99983138

24/212 AceView cDNA sequences (see all 212 ):

AI291172 BE465439 AA371023 BX354062 AA776726 CF140521 BI908255 CR593887

NM_021075 AI609645 BM683940 AI570479 BP336670 AA877479 BM471674 CR616335

CR613268 BF726930 BI829092 AA725824 AA894770 BM905262 BM475614 AW007204

highest scoring ESTs for WDR4:

AI478255 AI631444 AI631689 AI826063 AJ243912 AJ243913 AW249251 BC001074 BC006341 BE264633

Unigene Cluster for WDR4:

WD repeat domain 4

Hs.248815 [show with all ESTs]

Unigene Representative Sequence: AK092786

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for WDR4 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:							-		-										-																-
SP2:					-		-		-						-				-
SP3:							-		-										-
SP4:															-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for WDR4

2 Ensembl transcripts including schematic representations:

ENST00000330317 ENST00000398208

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR4

¹ / ² / ³

13 probe-sets matching WDR4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88002_at²^{, 3}	U95-E	1	1.00	1.00	0.63	1.11	AI478255	0.80	1.00	0.91	1
71350_at²^{, 3}	U95-D	1	1.00	1.00	0.08	0.74	AI918804	0.40	1.00	0.76	1
69243_r_at²^{, 3}	U95-E	1	1.00	1.00	0.56	0.83	AI631444	0.80	1.00	0.91	1
77041_at²^{, 3}	U95-E	1	1.00	1.00	0.63	0.89	AI631689	0.80	1.00	0.91	1
62282_s_at²^{, 3}	U95-C	1	1.00	1.00	0.76	1.24	AA577678	0.20	1.00	0.72	1
69240_s_at²^{, 3}	U95-E	2	1.00	0.97	0.63	1.08	AI631444	0.80	1.00	0.91	1
50150_s_at²^{, 3}	U95-C	3	1.00	0.94	0.33	1.13	AI826063	0.80	1.00	0.91	1
221632_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001074	0.80	1.00	0.91	1
241937_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA577678	0.20	1.00	0.72	1
226882_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI861913	0.60	1.00	0.82	1
221632_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
241937_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
226882_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAAGAAGAT

SOURCE GeneReport for Unigene cluster: Hs.248815

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR4¹	--	WD repeat domain 4	83.13(n) 80.65(a)	487783 XM_544908.2 XP_544908.2
chimpanzee (Pan troglodytes)	WDR4¹	--	WD repeat domain 4	98.79(n) 98.3(a)	458584 XM_514923.2 XP_514923.2
cow (Bos taurus)	WDR4¹	--	WD repeat domain 4	81.67(n) 79.81(a)	508051 XM_584777.3 XP_584777.3
mouse (Mus musculus)	Wdr4^{1, 5}	17⁵	WD repeat domain 4^{1, 5}	80.21(n)¹ 75.91(a)¹	57773¹ NM_021322.1¹ NP_067297.1¹ AI413865⁵ AI415180⁵ (see all 20)
chicken (Gallus gallus)	WDR4¹	--	WD repeat domain 4	62.51(n) 57.36(a)	418540 XM_416749.2 XP_416749.2

About this table Species with no ortholog for WDR4

ENSEMBL Gene Tree for WDR4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/336 NCBI SNPs in WDR4 are shown (see all 336 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 111)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2248490^1,2	A,C,F,H,O	43166813(+)	`CCAGAC/GTTGGA`	2	K/N	mis¹ ese³		22	EA NA MN EU WA	3419
	rs2839597^1,2	A,C,F,H,O	43174525(+)	`GGTCTA/GATAAT`	2	--	ng3¹ tfbs³		12	NA EU EA WA	940
	rs2839596^1,2	A,C,F,O	43174047(+)	`TAAAAA/GCTTTA`	2	--	ng3¹		4	NA	149
	rs7281655^1,2	A,C,F,H	43142812(+)	`CCTGGA/GTGCTG`	2	--	int¹ ut3¹		4	EU EA WA	416
	rs3761379^1,2	A,C,F,H	43173849(+)	`CAGCTC/TTTGCC`	2	--	ng3¹		3	EU EA	296
	rs2156314^1,2	A,C,F,H	43142723(+)	`GGCTAT/CGGCTG`	2	--	ut3¹ int¹		5	EA EU WA	1906
	rs2156315^1,2	A,C,F,H	43142750(+)	`AAGCAC/TTCGTG`	2	--	int¹ ut3¹		5	EA WA NA	480
	rs6586250^1,2	A,C,F,H	43143298(+)	`GACTCC/TGGCGC`	2	R/Q	mis¹ ese³		9	EU EA WA NA	890
	rs2156316^1,2	A,C,F,H	43142894(+)	`GCAGCG/CGACAC`	2	--	ut3¹ int¹		4	EU EA WA	416
	rs9974410^1,2	A,C,F,H	43136153(+)	`GCTTAA/CAACAA`	1	--	ng5¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for WDR4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605924

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/11 PubMed articles for WDR4 gene (see all 11 ):

Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PubMed id 12403464)^{1, 3, 4} Alexandrov A.... Phizicky E.M. (2002)
Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. (PubMed id 10950928)^{1, 3, 4} Michaud J.... Scott H.S. (2000)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PubMed id 15861136)^{3, 4} Cartlidge R.A....Cohen P. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)³ Hu Y.H....Janitz M. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10785	HGNC: 12756	AceView: NDUFV3	Ensembl:ENSG00000160193	euGenes: HUgn10785
ECgene: WDR4	H-InvDB: WDR4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR4		Antibodies for WDR4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for WDR4

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Antibodies for WDR4

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WDR4 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for WDR4

Summaries
for WDR4

Genomic Location
for WDR4

Proteins
for WDR4

Protein Domains/
Families
for WDR4

Gene Function
for WDR4

Pathways & Interactions
for WDR4

Drugs & Compounds
for WDR4

Transcripts
for WDR4

Expression
for WDR4

Orthologs
for WDR4

Paralogs
for WDR4

SNPs/Variants
for WDR4

Disorders & Mutations
for WDR4

Medical News
for WDR4

Publications
for WDR4

Search for WDR4

Genome Databases showing WDR4

Other Databases showing WDR4

Specialized Databases showing WDR4

Licensable Technologies
for WDR4

Services
for WDR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR4 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor WDR4

Summariesfor WDR4

Genomic Locationfor WDR4

Proteinsfor WDR4

Protein Domains/Familiesfor WDR4

Gene Functionfor WDR4

Pathways & Interactionsfor WDR4

Drugs & Compoundsfor WDR4

Transcriptsfor WDR4

Expression for WDR4

Orthologsfor WDR4

Paralogsfor WDR4

SNPs/Variantsfor WDR4

Disorders & Mutationsfor WDR4

Medical Newsfor WDR4

Publicationsfor WDR4

Search for WDR4

Genome Databases showing WDR4

Other Databases showing WDR4

Specialized Databases showing WDR4

Licensable Technologiesfor WDR4

Servicesfor WDR4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR4

Summaries
for WDR4

Genomic Location
for WDR4

Proteins
for WDR4

Protein Domains/
Families
for WDR4

Gene Function
for WDR4

Pathways & Interactions
for WDR4

Drugs & Compounds
for WDR4

Transcripts
for WDR4

Expression
for WDR4

Orthologs
for WDR4

Paralogs
for WDR4

SNPs/Variants
for WDR4

Disorders & Mutations
for WDR4

Medical News
for WDR4

Publications
for WDR4

Licensable Technologies
for WDR4

Services
for WDR4