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WDR4 Gene

protein-coding   GIFtS: 53
GCID: GC21M044263

WD Repeat Domain 4

  See WDR4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
WD Repeat Domain 42 11     TRMT822
WD Repeat-Containing Protein 42 3     TRM82 TRNA Methyltransferase 82 Homolog2
TRM82 TRNA Methyltransferase 82 Homolog (S. Cerevisiae)1     TRNA (Guanine-N(7)-)-Methyltransferase Non-Catalytic Subunit WDR42
TRM822     TRNA (Guanine-N(7)-)-Methyltransferase Subunit WDR42

External Ids:    HGNC: 127561   Entrez Gene: 107852   Ensembl: ENSG000001601937   OMIM: 6059245   UniProtKB: P570813   

Export aliases for WDR4 gene to outside databases

Previous GC identifers: GC21M040810 GC21M043157 GC21M043136 GC21M029678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR4 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is
excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other
disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for WDR4 Gene:
WDR4 (WD repeat domain 4) is a protein-coding gene. Diseases associated with WDR4 include nonsyndromic deafness. GO annotations related to this gene include tRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is
required to stabilize and induce conformational changes of the catalytic subunit

Gene Wiki entry for WDR4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR4 gene promoter:
         ATF-2   c-Ets-1   E47   HEN1   E2F-1   E2F   Hand1   ZIC2/Zic2   c-Jun   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR4 promoter sequence

   Search Chromatin IP Primers for WDR4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
WDR4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR4 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M044263:   GeneLoc Nature:405,311-319
Start:
44,263,204 bp from pter       29,816,661 bp from centromere
End:
44,299,678 bp from pter 29,846,963 bp from centromere
Size:
36,475 bases 30,303 bases
Orientation:
minus strand minus strand

genomic clones: KB51A8 KB1405B7


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081 (See protein sequence)
Recommended Name: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4  
Size: 412 amino acids; 45490 Da
Subunit: Forms a heterodimer with the catalytic subunit METTL1
Secondary accessions: A8KA58 B2RCA3 B4DNQ7 D3DSK3 Q9BVM5 Q9HCR3
Alternative splicing: 3 isoforms:  P57081-1   P57081-2   P57081-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for WDR4: NX_P57081

Explore proteomics data for WDR4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See WDR4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001247403.1  NP_001247404.1  NP_001247405.1  NP_001247406.1  NP_061139.2  NP_387510.1  

    ENSEMBL proteins: 
     ENSP00000328671   ENSP00000381266  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR028884 Trm82
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P57081

    ProtoNet protein and cluster: P57081

    UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
    Similarity: Belongs to the WD repeat TRM82 family
    Similarity: Contains 5 WD repeats


    Find genes that share domains with WDR4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR4_HUMAN, P57081
    Function: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is
    required to stabilize and induce conformational changes of the catalytic subunit

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15861136
    GO:0008176contributes to tRNA (guanine-N7-)-methyltransferase activity IDA12403464
         
    Find genes that share ontologies with WDR4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR4
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    miRTarBase miRNAs that target WDR4:
    hsa-let-7b-5p (MIRT032196), hsa-let-7e-5p (MIRT051666), hsa-mir-615-3p (MIRT039661), hsa-mir-100-5p (MIRT048521), hsa-mir-877-3p (MIRT036980), hsa-mir-26b-5p (MIRT029098), hsa-mir-484 (MIRT041960)

    Block miRNA regulation of human, mouse, rat WDR4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate WDR4:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR4_HUMAN, P57081: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm IDA16780588
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with WDR4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: WDR4_HUMAN, P57081
    Pathway: tRNA modification; N(7)-methylguanine-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR4
    Interactions:

        Search GeneGlobe Interaction Network for WDR4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for WDR4 (P570812, 3 ENSP000003286714) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    METTL1Q9UBP63, ENSP000003144414I2D: score=6 STRING: ENSP00000314441
    TRMT10AENSP000002739624STRING: ENSP00000273962
    PUS1ENSP000003658374STRING: ENSP00000365837
    KYNUENSP000002641704STRING: ENSP00000264170
    PUS7ENSP000003487224STRING: ENSP00000348722
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006400tRNA modification IDA15861136
    GO:0036265RNA (guanine-N7)-methylation ----

    Find genes that share ontologies with WDR4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR4 gene (6 alternative transcripts): 
    NM_001260474.1  NM_001260475.1  NM_001260476.1  NM_001260477.1  NM_018669.5  NM_033661.4  

    Unigene Cluster for WDR4:

    WD repeat domain 4
    Hs.248815  [show with all ESTs]
    Unigene Representative Sequence: NM_001260477
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330317(uc002zci.3) ENST00000492742 ENST00000398208(uc002zck.1 uc010gpg.1 uc010gph.1 uc011aew.1)
    ENST00000476326(uc002zcl.1) ENST00000479429 ENST00000463902 ENST00000470658

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate WDR4:
    hsa-miR-518f*
    SwitchGear 3'UTR luciferase reporter plasmidWDR4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for WDR4
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    GenScript: all cDNA clones in your preferred vector (see all 2): WDR4 (NM_001164267)
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    OriGene qPCR primer pairs and template standards for WDR4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR4
      QuantiTect SYBR Green Assays in human, mouse, rat WDR4
      QuantiFast Probe-based Assays in human, mouse, rat WDR4

    Additional mRNA sequence: 

    AJ243912.1 AJ243913.1 AK056343.1 AK292923.1 AK298015.1 AK315008.1 BC001074.2 BC006341.2 
    BC018866.2 NR_048535.1 

    9 DOTS entries:

    DT.85101595  DT.100846297  DT.95360576  DT.40130265  DT.95360578  DT.97854856  DT.121131946  DT.100031099 
    DT.95340656 

    Selected AceView cDNA sequences (see all 212):

    AI291172 AA894770 BE465439 BQ001645 CF140521 BU621933 AA371023 BI908255 
    BM471674 F32007 AA776726 AA725824 AI570479 CR542190 AI609645 NM_021075 
    NM_001001503 BM683940 BF726930 CR607646 CR593887 AW137829 CB113244 CA392874 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for WDR4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:                    -     -                             -                                               -         
    SP2:              -     -     -                 -           -                                                         
    SP3:                    -     -                             -                                                         
    SP4:                                            -           -                                                         
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for WDR4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGAAGAT
    WDR4 Expression
    About this image

    WDR4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248815
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for WDR4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr41 , 5 WD repeat domain 41, 5 79.92(n)1
    76.1(a)1
      17 (16.56 cM)5
    577731  NM_021322.21  NP_067297.21 
     314943235 
    chicken
    (Gallus gallus)
    Aves WDR41 WD repeat domain 4 62.43(n)
    57.11(a)
      418540  XM_416749.4  XP_416749.4 
    lizard
    (Anolis carolinensis)
    Reptilia WDR46
    WD repeat domain 4
    52(a)
    1 ↔ 1
    3(137452796-137474857)
    African clawed frog
    (Xenopus laevis)
    Amphibia wdr4-prov2 WD repeat domain 4 76.21(n)    BC043907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005366371 tRNA (guanine-N(7)-)-methyltransferase subunit WDR4-like 53.14(n)
    48.86(a)
      100536637  XM_003199199.2  XP_003199247.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wuho6
    wuho
    24(a)
    1 ↔ 1
    X(6182156-6183595)
    worm
    (Caenorhabditis elegans)
    Secernentea Y102E9.26
    Protein Y102E9.2, isoform b (Y102E9.2) mRNA, compl...
    21(a)
    1 ↔ 1
    III(6725789-6728058) WBGene00022420
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM82(YDR165W)4 Subunit of a tRNA methyltransferase complex composed more   --   4(784871-786205) 851743  NP_010449.1 


    ENSEMBL Gene Tree for WDR4 (if available)
    TreeFam Gene Tree for WDR4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR4 gene

    Find genes that share paralogs with WDR4           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for WDR4
    PGOHUM00000240080 PGOHUM00000241560


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR4 (see all 1250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421877561,2
    C--29684482(+) GATCAC/GGCGGC 6 -- ds50010--------
    rs1461757481,2
    C--29684490(+) GGCGCA/GCACCT 6 -- ds50010--------
    rs732316861,2
    C,F--44262773(+) TACCCG/ACAAAG 1 -- ds50011Minor allele frequency- A:0.01NA 120
    rs733667831,2
    C,F--44262819(+) CCAGCG/ATCCCG 1 -- ds50013Minor allele frequency- A:0.13WA CSA 122
    rs1404535511,2
    C--44262825(+) TCCCGC/TTGGGG 1 -- ds50010--------
    rs1889808121,2
    C--44262835(+) GTCTTC/TGGATG 1 -- ds50010--------
    rs1503945891,2
    C--44262912(+) CCTCCA/GGAGGG 1 -- ds50010--------
    rs563745351,2
    C,F--44263041(+) CTAAAT/ACATCC 1 -- ds50019Minor allele frequency- A:0.42NA WA CSA EA 369
    rs99744101,2
    C,F,A,H--44263084(+) GCTTAA/CAACAA 1 -- ds500119Minor allele frequency- C:0.37NS EA NA CSA WA 2346
    rs1381010841,2
    --44263158(+) TTAAAG/TGAACC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for WDR4 (44263204 - 44299678 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for WDR4 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723577CNV Deletion23290073
    esv2666871CNV Deletion23128226
    esv2723579CNV Deletion23290073
    esv2723578CNV Deletion23290073
    esv2723576CNV Deletion23290073
    nsv834105CNV Loss17160897
    nsv913806CNV Loss21882294
    nsv913819CNV Loss21882294
    nsv913818CNV Loss21882294
    dgv4753n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): WDR4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR4
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605924    OMIM disorders: --

    1 disease for WDR4:    
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    nonsyndromic deafness


    Find genes that share disorders with WDR4           About GenesLikeMe

    Genetic Association Database (GAD): WDR4

    Export disorders for WDR4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR4 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with WDR4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. (PubMed id 12403464)1, 2, 3, 9 Alexandrov A.... Phizicky E.M. (RNA 2002)
    2. Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein. (PubMed id 10950928)1, 2, 9 Michaud J.... Scott H.S. (Genomics 2000)
    3. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. (PubMed id 15861136)1, 2 Cartlidge R.A....Cohen P. (EMBO J. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10785 HGNC: 12756 AceView: NDUFV3 Ensembl:ENSG00000160193 euGenes: HUgn10785
    ECgene: WDR4 H-InvDB: WDR4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for WDR4 gene:
    Search GeneIP for patents involving WDR4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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