Aliases for WDR4 Gene
External Ids for WDR4 Gene
Previous GeneCards Identifiers for WDR4 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for WDR4 Gene
WDR4 (WD Repeat Domain 4) is a Protein Coding gene. Diseases associated with WDR4 include Isolated Growth Hormone Deficiency, Type Ia and Nonsyndromic Deafness. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include tRNA (guanine-N7-)-methyltransferase activity.
UniProtKB/Swiss-Prot for WDR4 Gene
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.