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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

WDR38 Gene

protein-coding GIFtS: 36
GCID: GC09P127615

WD repeat domain 38

Search for WDR38
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
WD Repeat Domain 38¹ ²
WD Repeat-Containing Protein 38²

External Ids:	HGNC: 23745¹	Entrez Gene: 401551²	Ensembl: ENSG00000136918⁷	UniProtKB: Q5JTN6³

Export aliases for WDR38 gene to outside databases

Previous GC identifers: GC09P126657 GC09P097229

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the WDR38 gene promoter:
MyoD AP-2gamma GATA-2 PPAR-gamma1 CP2 AP-2beta PPAR-gamma2 AP-2alpha CBF(2) AP-2alphaA
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR38

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3

WDR38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR38 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P127615: view genomic region (about GC identifiers)

Start:	127,615,755 bp from pter	End:	127,620,160 bp from pter
Size:	4,406 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6 (See protein sequence)

Recommended Name: WD repeat-containing protein 38

Size: 314 amino acids; 34312 Da

Secondary accessions: A0PK24

Explore the universe of human proteins at neXtProt for WDR38: NX_Q5JTN6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5JTN6

WDR38 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001038941.1 NP_001263303.1 NP_001263304.1 NP_001263305.1

ENSEMBL proteins:

ENSP00000362677

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

WDR38 for domains About GeneDecksing

5 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q5JTN6

ProtoNet protein and cluster: Q5JTN6

UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for WDR38

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about WDR38

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for WDR38 gene (4 alternative transcripts):

NM_001045476.2 NM_001276374.1 NM_001276375.1 NM_001276376.1

Unigene Cluster for WDR38:

WD repeat domain 38

Hs.343383 [show with all ESTs]

Unigene Representative Sequence: BM007268

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000373574(uc011lzn.2 uc011lzo.2 uc011lzp.2 uc004box.3)

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Additional cDNA sequence:

BC127949.1 BC150645.1 BC171828.1 BC171830.1 BC171837.1

12 DOTS entries:

DT.91981706 DT.95102648 DT.423949 DT.92002937 DT.121063320 DT.91769340 DT.91749793 DT.102840119

DT.91769348 DT.95099885 DT.91888037 DT.95102653

14 AceView cDNA sequences:

BU101832 BF513871 BM981761 AA478887 BX108090 BM975209 AA478768 BI769504

AI915356 AI139841 BF515709 AI190548 BF941899 AA867995

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

WDR38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAGGACTC

About this image

WDR38 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See WDR38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR38

SOURCE GeneReport for Unigene cluster: Hs.343383

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for WDR38 gene from 1/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	wdr38¹	WD repeat domain 38	55.33(n) 50.76(a)		550366 NM_001017672.1 NP_001017672.1

ENSEMBL Gene Tree for WDR38 (if available)
TreeFam Gene Tree for WDR38 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for WDR38 gene

POC1B² WDR83² WDR5² ATG16L1² WDR88² SNRNP40² WDR5B² KATNB1²

PAFAH1B1² PRPF4² DAW1² ATG16L2² POC1A² WDSUB1²

18/21 SIMAP similar genes for WDR38 using alignment to 4 protein entries: WDR38_HUMAN (see all proteins) (see all similar genes):

POC1B PF20 WDR83 WSB1 WDR69 DKFZp434D199

WDR5B GNB2 BUB3 DKFZp762M0115 NLE1 WDR88

WDR5 PAFAH1B1 PLRG1 SNRNP40 WDR86 POC1A

WDR38 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150901118^1,2		--	127613755(+)	`CAAAGA/TGCTAG`	1	--	us2k¹		0	--	--	--	--
rs192145347^1,2		--	127613814(+)	`TTGACA/GTGCGT`	1	--	us2k¹		0	--	--	--	--
rs138399121^1,2		--	127613817(+)	`ACATGC/TGTAGC`	1	--	us2k¹		0	--	--	--	--
rs75184883^1,2		--	127613890(+)	`AAAAGC/TCAGCG`	1	--	us2k¹		1		NA	120
rs12001238^1,2	C,F,A,H,	--	127614051(+)	`ATGATC/GCTCCG`	1	--	us2k¹		9		NS EA NA CSA WA	640
rs72763356^1,2	C,	--	127614117(+)	`GGTTTC/TGACCC`	1	--	us2k¹		0	--	--	--	--
rs4837002^1,2	C,F,H,	--	127614169(+)	`ACAAGG/TTCTAC`	1	--	us2k¹		5		NS NA	208
rs192856737^1,2		--	127614206(+)	`GGGCTG/TGGGAA`	1	--	us2k¹		0	--	--	--	--
rs12001292^1,2	C,F,H,	--	127614213(+)	`GGAAGG/ATGGCT`	1	--	us2k¹		4		NA CSA WA EA	245
rs117553617^1,2	F,	--	127614245(+)	`GGAGCA/CACCAA`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for WDR38 (127615755 - 127620160 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for WDR38: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for WDR38 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR38)

Utopia: connect your pdf to the dynamic
world of online information

DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 401551	HGNC: 23745	AceView: LOC401551	Ensembl:ENSG00000136918	euGenes: HUgn401551
ECgene: WDR38	H-InvDB: WDR38

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for WDR38	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR38 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for WDR38 gene:
Search GeneIP for patents involving WDR38

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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WDR38 Gene

WD repeat domain 38

Aliases
for WDR38 gene

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for WDR38 gene

Genomic Views
for WDR38 gene

Proteins
for WDR38 gene

Protein Domains /
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for WDR38 gene

Function
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Pathways & Interactions
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Drugs & Compounds
for WDR38 gene

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for WDR38 gene

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WDR38 Gene

WD repeat domain 38

Aliasesfor WDR38 gene

Summariesfor WDR38 gene

Genomic Viewsfor WDR38 gene

Proteinsfor WDR38 gene

Protein Domains /Familiesfor WDR38 gene

Functionfor WDR38 gene

Pathways & Interactionsfor WDR38 gene

Drugs & Compoundsfor WDR38 gene

Transcriptsfor WDR38 gene

Expression for WDR38 gene

Orthologsfor WDR38 gene

Paralogsfor WDR38 gene

Genomic Variantsfor WDR38 gene

Disorders / Diseasesfor WDR38 gene

Publicationsfor WDR38 gene

External Searches for WDR38 gene

Genome Databases showing WDR38 gene

Other Databases showing WDR38 gene

Specialized Databases showing WDR38 gene

Intellectual Propertyfor WDR38 gene

Productsfor WDR38 gene

View Random Gene

Aliases
for WDR38 gene

Summaries
for WDR38 gene

Genomic Views
for WDR38 gene

Proteins
for WDR38 gene

Protein Domains /
Families
for WDR38 gene

Function
for WDR38 gene

Pathways & Interactions
for WDR38 gene

Drugs & Compounds
for WDR38 gene

Transcripts
for WDR38 gene

Expression
for WDR38 gene

Orthologs
for WDR38 gene

Paralogs
for WDR38 gene

Genomic Variants
for WDR38 gene

Disorders / Diseases
for WDR38 gene

Publications
for WDR38 gene

Intellectual Property
for WDR38 gene

Products
for WDR38 gene