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Aliases for WDR38 Gene

Aliases for WDR38 Gene

  • WD Repeat Domain 38 2 3 5

External Ids for WDR38 Gene

Previous GeneCards Identifiers for WDR38 Gene

  • GC09P126657
  • GC09P127615
  • GC09P097229

Summaries for WDR38 Gene

GeneCards Summary for WDR38 Gene

WDR38 (WD Repeat Domain 38) is a Protein Coding gene. An important paralog of this gene is DAW1.

Additional gene information for WDR38 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR38 Gene

Genomics for WDR38 Gene

GeneHancer (GH) Regulatory Elements for WDR38 Gene

Promoters and enhancers for WDR38 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I124851 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.4 -413 2.5 PKNOX1 ATF1 ARID4B SIN3A ZNF2 ZBTB7B ZNF48 YY1 GLIS2 ZNF213 WDR38 ARPC5L OLFML2A PIR55692
GH09I124768 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.6 -82.7 -82694 3.5 CLOCK MLX FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC NR6A1 ENSG00000236643 PRPS1P2 GAPVD1 GOLGA1 WDR38 RPL35 ARPC5L MIR181A2HG
GH09I124799 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 12.1 -52.0 -52034 3.3 CTCF EBF1 ZIC2 RFX5 ZNF335 GLIS1 IKZF1 MLLT1 IKZF2 SPI1 OLFML2A WDR38 ARPC5L RPL35 GAPVD1 RNU6-1020P MIR181A2HG PIR55692
GH09I124795 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -56.6 -56600 3.4 ELF3 PKNOX1 FOXA2 SREBF2 ARID4B RAD21 ZNF48 ZSCAN9 RARA ZNF121 WDR38 ARPC5L RPL35 GAPVD1 RNU6-1020P MIR181A2HG PIR55692 OLFML2A
GH09I124774 Enhancer 1 Ensembl ENCODE 13.6 -78.7 -78685 0.7 ELF3 ATF1 RB1 ARID4B KLF17 MZF1 ZNF2 IRF4 RAD21 RFX5 WDR38 RPL35 ARPC5L MIR181A2HG NR6A1 OLFML2A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around WDR38 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WDR38 gene promoter:

Genomic Locations for WDR38 Gene

Genomic Locations for WDR38 Gene
chr9:124,853,347-124,857,891
(GRCh38/hg38)
Size:
4,545 bases
Orientation:
Plus strand
chr9:127,615,755-127,620,160
(GRCh37/hg19)

Genomic View for WDR38 Gene

Genes around WDR38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR38 Gene

Proteins for WDR38 Gene

  • Protein details for WDR38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTN6-WDR38_HUMAN
    Recommended name:
    WD repeat-containing protein 38
    Protein Accession:
    Q5JTN6
    Secondary Accessions:
    • A0PK24

    Protein attributes for WDR38 Gene

    Size:
    314 amino acids
    Molecular mass:
    34312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WDR38 Gene

Post-translational modifications for WDR38 Gene

No Post-translational modifications

Other Protein References for WDR38 Gene

No data available for DME Specific Peptides for WDR38 Gene

Domains & Families for WDR38 Gene

Gene Families for WDR38 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR38 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR38: view

No data available for UniProtKB/Swiss-Prot for WDR38 Gene

Function for WDR38 Gene

Phenotypes From GWAS Catalog for WDR38 Gene

genes like me logo Genes that share phenotypes with WDR38: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for WDR38 Gene

Localization for WDR38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR38 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for WDR38 Gene

Pathways & Interactions for WDR38 Gene

SuperPathways for WDR38 Gene

No Data Available

Interacting Proteins for WDR38 Gene

Gene Ontology (GO) - Biological Process for WDR38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR38 Gene

Drugs & Compounds for WDR38 Gene

No Compound Related Data Available

Transcripts for WDR38 Gene

mRNA/cDNA for WDR38 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WDR38 Gene

WD repeat domain 38:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR38 Gene

No ASD Table

Relevant External Links for WDR38 Gene

GeneLoc Exon Structure for
WDR38
ECgene alternative splicing isoforms for
WDR38

Expression for WDR38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR38 Gene

mRNA differential expression in normal tissues according to GTEx for WDR38 Gene

This gene is overexpressed in Testis (x11.6), Fallopian Tube (x8.5), Cervix - Endocervix (x7.7), Lung (x6.1), and Brain - Hypothalamus (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR38 Gene



Protein tissue co-expression partners for WDR38 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR38 Gene:

WDR38

SOURCE GeneReport for Unigene cluster for WDR38 Gene:

Hs.343383
genes like me logo Genes that share expression patterns with WDR38: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR38 Gene

Orthologs for WDR38 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR38 33 34
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia WDR38 33 34
  • 83.9 (n)
rat
(Rattus norvegicus)
Mammalia Wdr38 33
  • 79.11 (n)
mouse
(Mus musculus)
Mammalia Wdr38 33 16 34
  • 78.31 (n)
dog
(Canis familiaris)
Mammalia WDR38 34
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR38 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr38 33
  • 59.6 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr38 33 34
  • 55.22 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 34
  • 16 (a)
OneToMany
Species where no ortholog for WDR38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for WDR38 Gene

ENSEMBL:
Gene Tree for WDR38 (if available)
TreeFam:
Gene Tree for WDR38 (if available)

Paralogs for WDR38 Gene

Paralogs for WDR38 Gene

genes like me logo Genes that share paralogs with WDR38: view

Variants for WDR38 Gene

Sequence variations from dbSNP and Humsavar for WDR38 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001774536 -- 124,857,230(+) G/A intron_variant
rs1002575809 -- 124,852,809(+) G/A upstream_transcript_variant
rs1002772779 -- 124,856,020(+) A/T intron_variant
rs1003489784 -- 124,853,513(+) G/A 5_prime_UTR_variant
rs1004131146 -- 124,856,205(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WDR38 Gene

Variant ID Type Subtype PubMed ID
nsv831721 CNV gain 17160897
nsv951760 CNV deletion 24416366

Variation tolerance for WDR38 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WDR38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR38 Gene

Disorders for WDR38 Gene

Additional Disease Information for WDR38

No disorders were found for WDR38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR38 Gene

Publications for WDR38 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for WDR38 Gene

Sources for WDR38 Gene

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