V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

WDR38 Gene

protein-coding   GIFtS: 35

GC09P126657
WD repeat domain 38
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
OTTHUMP00000022116 2
Descriptions
WD repeat domain 38 2
External Ids
HGNC: 237451
Entrez Gene: 4015512
UniProtKB: Q5JTN63
Ensembl: ENSG000001369187
Search outside databases for aliases for WDR38 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

WDR38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P126657:     (about GC identifiers)

Start:
126,655,576 bp from pter
End:
126,659,981 bp from pter
Size:
4,406 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008470.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6 (See protein sequence)
Recommended Name: WD repeat-containing protein 38  
Size: 314 amino acids; 34312 Da
Secondary accessions: A0PK24

REFSEQ proteins: NP_001038941.1  

ENSEMBL proteins: 
ENSP00000362677 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
              OriGene Purified Recombinant Human Protein: WDR38 


Antibodies for WDR38: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR38

Assays for WDR38: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/6 InterPro domains/families (see all 6 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR017986 WD40_repeat_region


   GeneDecks  WDR38 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q5JTN6

ProtoNet protein and cluster: Q5JTN6

UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6
Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR38)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001045476

              Applied Biosystems Silencer® siRNAs for WDR38

              Sigma-Aldrich siRNA for WDR38  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001045476
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001045476
                                 untagged cDNA clone in CMV expression vector: NM_001045476 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001045476

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR38

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR38)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001045476

              Sigma-Aldrich siRNA for WDR38  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001045476  

REFSEQ mRNAs for WDR38 gene: 

NM_001045476.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001045476  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001045476
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001045476
                                 untagged cDNA clone in CMV expression vector: NM_001045476 

Additional cDNA sequence: 

BC127949.1 BC150645.1 BC171828.1 BC171830.1 BC171837.1 

4 DOTS entries:

DT.423949  DT.91749793  DT.95099885  DT.92002937 

14 AceView cDNA sequences:

AI139841 BU101832 BM981761 BI769504 BF515709 BF513871 BM975209 BX108090 
AA478887 AI915356 AA478768 AI190548 BF941899 AA867995 

Unigene Cluster for WDR38:

WD repeat domain 38
Hs.343383  [show with all ESTs]
Unigene Representative Sequence: NM_001045476


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000373574  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR38 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR38

1 / 2

3 probe-sets matching WDR38 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
75400_at2 U95-E 1 1.00 1.00 1.00 1.00 -- -- -- -- --

243900_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

243900_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  WDR38 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCCAGGACTC

SOURCE GeneReport for Unigene cluster: Hs.343383
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR38 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
WDR381   -- WD repeat domain 38 99.15(n)
98.73(a)
738043  XM_001143067.1  XP_001143067.1 
cow
(Bos taurus)
WDR381   -- WD repeat domain 38 84.07(n)
80.15(a)
787677  XM_001254989.1  XP_001254990.1 
rat
(Rattus norvegicus)
Wdr381   -- WD repeat domain 38 80.37(n)
80.08(a)
366035  XM_575125.2  XP_575125.2 
mouse
(Mus musculus)
Wdr381, 5 25
WD repeat domain 381, 5 78.19(n)1
76.61(a)1
766461  NM_029687.21  NP_083963.11 
 AK0072465  AK0433015  (see all 10)
zebrafish
(Danio rerio)
LOC7921241   -- hypothetical LOC792124 56.01(n)
51.03(a)
792124  XM_001331068.2  XP_001331104.2 
About this table        Species with no ortholog for WDR38

ENSEMBL Gene Tree for WDR38
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR38 gene
WDR612  PRPF192  WDR882  KATNB12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/46 NCBI SNPs in WDR38 are shown (see all 46 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 9 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs78559031,2
A,C,F,H126654564(+) gcaccG/Agctag 1 -- ng514Minor allele frequency- A:0.30EU EA WA 372
rs120012381,2
A,C,F,H126653872(+) ATGATC/GCTCCG 1 -- ng514Minor allele frequency- G:0.13EU EA WA 396
rs107603811,2
C,F,H126658660(+) CAGTGG/CCAACA 1 G/A mis14Minor allele frequency- C:0.02EU EA WA 418
rs109864661,2
A,F,H126655365(+) CCTAGG/AGTGGA 1 -- ng513Minor allele frequency- A:0.36EU EA 274
rs22749701,2
C,F,H126658597(-) AGATGC/TGTACG 1 H/R mis1 ese34Minor allele frequency- T:0.13EU EA WA 418
rs107603791,2
A,C,F126655053(+) ATCCTC/TAACCT 1 -- ng513Minor allele frequency- T:0.42NA 142
rs109864671,2
C,F,H126655526(+) CGATTA/GCCATG 1 -- ng513Minor allele frequency- G:0.39EU EA 270
rs48370021,2
H126653990(+) ACAAGG/TTCTAC 1 -- ng512Minor allele frequency- T:0.01EU WA 196
rs120012921,2
C126654034(+) GGAAGA/GTGGCT 1 -- ng510--------
rs109864651,2
H126654080(+) GCTAGA/GCAATG 1 -- ng514Minor allele frequency- G:0.00EU EA WA 412
About this table

HapMap Linkage Disequilibrium images for WDR38 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

3 PubMed articles for WDR38 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 401551 HGNC: 23745 AceView: LOC401551 Ensembl:ENSG00000136918 euGenes: HUgn401551
ECgene: WDR38 H-InvDB: WDR38
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR38:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR38-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR38 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Browse shRNAs at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Search for Recombinant Proteins
 Search for Antibodies
 Search for Chimera RNAi
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Search for Recombinant Proteins
 Search for Antibodies
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for WDR38




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for WDR38

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
WDR38 Gene at Home site.
Version 2.41.1
server5.xennexinc.com