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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR38 Gene

protein-coding   GIFtS: 36
GCID: GC09P127615

WD Repeat Domain 38

  Search for WDR38
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 381 2
WD Repeat-Containing Protein 382

External Ids:    HGNC: 237451   Entrez Gene: 4015512   Ensembl: ENSG000001369187   UniProtKB: Q5JTN63   

Export aliases for WDR38 gene to outside databases

Previous GC identifers: GC09P126657 GC09P097229


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for WDR38 Gene: 
WDR38 (WD repeat domain 38) is a protein-coding gene. An important paralog of this gene is WDR83.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR38 gene promoter:
         MyoD   AP-2gamma   GATA-2   PPAR-gamma1   CP2   AP-2beta   PPAR-gamma2   AP-2alpha   CBF(2)   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for WDR38

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR38


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

WDR38 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR38 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P127615:  view genomic region     (about GC identifiers)

Start:
127,615,755 bp from pter      End:
127,620,160 bp from pter
Size:
4,406 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6 (See protein sequence)
Recommended Name: WD repeat-containing protein 38  
Size: 314 amino acids; 34312 Da
Secondary accessions: A0PK24

Explore the universe of human proteins at neXtProt for WDR38: NX_Q5JTN6

Explore proteomics data for WDR38 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JTN6

  • WDR38 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR38 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001038941.1  NP_001263303.1  NP_001263304.1  NP_001263305.1  

    ENSEMBL proteins: 
     ENSP00000362677  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5JTN6

    ProtoNet protein and cluster: Q5JTN6

    UniProtKB/Swiss-Prot: WDR38_HUMAN, Q5JTN6
    Similarity: Contains 7 WD repeats


    WDR38 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR38 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR38

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR38

    Search CenterWatch for drugs/clinical trials and news about WDR38

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for WDR38 gene (4 alternative transcripts): 
    NM_001045476.2  NM_001276374.1  NM_001276375.1  NM_001276376.1  

    Unigene Cluster for WDR38:

    WD repeat domain 38
    Hs.343383  [show with all ESTs]
    Unigene Representative Sequence: NM_001276374
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373574(uc011lzn.2 uc011lzo.2 uc011lzp.2 uc004box.3)

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    Additional mRNA sequence: 

    BC127949.1 BC150645.1 BC171828.1 BC171830.1 BC171837.1 

    4 DOTS entries:

    DT.423949  DT.91749793  DT.95099885  DT.92002937 

    14 AceView cDNA sequences:

    AI139841 BM981761 BX108090 BM975209 AI915356 AA478768 BU101832 BF513871 
    BI769504 BF515709 AA478887 AI190548 BF941899 AA867995 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR38 expression in normal human tissues (normalized intensities)      WDR38 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGGACTC
    WDR38 Expression
    About this image


    WDR38 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Epithelium (Respiratory System)    fully expand to see all 2 entries
             bronchial epithelial cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See WDR38 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR38

    SOURCE GeneReport for Unigene cluster: Hs.343383
        SABiosciences Custom PCR Arrays for WDR38
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR38

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for WDR38 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr381 , 5 WD repeat domain 381, 5 78.31(n)1
    76.61(a)1
      2 (24.42 cM)5
    766461  NM_029687.31  NP_083963.11 
     389974765 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr381 WD repeat domain 38 55.33(n)
    50.76(a)
      550366  NM_001017672.1  NP_001017672.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta kat806
    katanin 80
    9(a)
    1 → many
    X(16161038-16170213)


    ENSEMBL Gene Tree for WDR38 (if available)
    TreeFam Gene Tree for WDR38 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR38 gene
    WDR832  POC1B2  WDR52  WDR482  ATG16L12  SNRNP402  WDR5B2  PAFAH1B12  
    SMU12  DAW12  PRPF42  ATG16L22  POC1A2  
    18 SIMAP similar genes for WDR38 using alignment to 4 protein entries:     WDR38_HUMAN (see all proteins):
    POC1B    PF20    WDR83    WSB1    DAW1    DKFZp434D199
    WDR5B    GNB2    BUB3    DKFZp762M0115    NLE1    WDR88
    WDR5    PLRG1    SNRNP40    WDR86    WDR61    WDSUB1

    WDR38 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 SNPs in WDR38 are shown (see all 219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs676298891,2
    C--97232127(+) CCCCT-/C/TC  
            
    CCTTT
    4 -- int11NA 2
    rs109864641,2
    C--127613733(+) TGATCT/CGCCTG 4 -- us2k1 tfbs34Minor allele frequency- C:0.32NA WA EA 360
    rs1509011181,2
    C--127613755(+) CAAAGA/TGCTAG 4 -- us2k10--------
    rs1921453471,2
    --127613814(+) TTGACA/GTGCGT 4 -- us2k10--------
    rs1383991211,2
    --127613817(+) ACATGC/TGTAGC 4 -- us2k10--------
    rs751848831,2
    F--127613890(+) AAAAGC/TCAGCG 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs120012381,2
    C,F,A,H--127614051(+) ATGATC/GCTCCG 4 -- us2k19Minor allele frequency- G:0.15NS EA NA CSA WA 640
    rs727633561,2
    C--127614117(+) GGTTTC/TGACCC 4 -- us2k10--------
    rs48370021,2
    C,F,H--127614169(+) ACAAGG/TTCTAC 4 -- us2k15Minor allele frequency- T:0.01NS NA 208
    rs1928567371,2
    --127614206(+) GGGCTG/TGGGAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for WDR38 (127615755 - 127620160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for WDR38:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831721CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR38 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with WDR38)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 401551 HGNC: 23745 AceView: LOC401551 Ensembl:ENSG00000136918 euGenes: HUgn401551
    ECgene: WDR38 H-InvDB: WDR38

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR38 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR38 gene:
    Search GeneIP for patents involving WDR38

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    transforming growth factor, beta 1
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