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Aliases for WDR37 Gene

Aliases for WDR37 Gene

  • WD Repeat Domain 37 2 3 5
  • KIAA0982 4

External Ids for WDR37 Gene

Previous GeneCards Identifiers for WDR37 Gene

  • GC10P001056
  • GC10P001085
  • GC10P001092
  • GC10P001041
  • GC10P001095

Summaries for WDR37 Gene

Entrez Gene Summary for WDR37 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR37 Gene

WDR37 (WD Repeat Domain 37) is a Protein Coding gene. An important paralog of this gene is WDR12.

Gene Wiki entry for WDR37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR37 Gene

Genomics for WDR37 Gene

Regulatory Elements for WDR37 Gene

Enhancers for WDR37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G001054 1.7 FANTOM5 ENCODE dbSUPER 19.5 +7.0 7020 4.4 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B WDR37 IDI2 IDI2-AS1 IDI1
GH10G001047 1.4 ENCODE dbSUPER 13.6 0.0 -47 4.0 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A WDR37 IDI2-AS1 IDI2
GH10G001042 0.9 ENCODE dbSUPER 19.7 -4.9 -4900 4.1 PAF1 TBP SMAD5 WRNIP1 MAX CEBPG ZNF394 ZIC2 POLR2A SCRT2 WDR37 IDI2-AS1 GTPBP4 LOC107984285 IDI2
GH10G000968 1.2 Ensembl ENCODE 13.7 -78.6 -78646 4.9 PKNOX1 FOXA2 ATF1 MLX ARID4B ZNF48 YY1 ZNF207 PAF1 JUNB WDR37 GTPBP4 LOC101927762 IDI2 PIR35547 LOC105376341
GH10G001109 0.8 ENCODE 17.1 +60.9 60934 1.5 WRNIP1 SIN3A RAD21 ZNF143 FOS ETV6 CREM ZNF654 JUNB REST WDR37 ADARB2 IDI2 GC10P001101 PIR40136
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR37 on UCSC Golden Path with GeneCards custom track

Promoters for WDR37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023417 -338 2801 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT CREB3L1 AGO1 WRNIP1 ARID4B SIN3A

Genomic Location for WDR37 Gene

Chromosome:
10
Start:
1,049,538 bp from pter
End:
1,132,297 bp from pter
Size:
82,760 bases
Orientation:
Plus strand

Genomic View for WDR37 Gene

Genes around WDR37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR37 Gene

Proteins for WDR37 Gene

  • Protein details for WDR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I8-WDR37_HUMAN
    Recommended name:
    WD repeat-containing protein 37
    Protein Accession:
    Q9Y2I8
    Secondary Accessions:
    • A8K976
    • D3DRQ7
    • Q5SW03
    • Q8WVG2
    • Q9NTJ6

    Protein attributes for WDR37 Gene

    Size:
    494 amino acids
    Molecular mass:
    54665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR37 Gene

Post-translational modifications for WDR37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR37 Gene

No data available for DME Specific Peptides for WDR37 Gene

Domains & Families for WDR37 Gene

Gene Families for WDR37 Gene

Suggested Antigen Peptide Sequences for WDR37 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with WDR37: view

No data available for UniProtKB/Swiss-Prot for WDR37 Gene

Function for WDR37 Gene

genes like me logo Genes that share phenotypes with WDR37: view

Animal Models for WDR37 Gene

MGI Knock Outs for WDR37:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR37 Gene

Localization for WDR37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR37 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030687 preribosome, large subunit precursor IBA --
GO:0070545 PeBoW complex IBA --
genes like me logo Genes that share ontologies with WDR37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for WDR37 Gene

Pathways & Interactions for WDR37 Gene

SuperPathways for WDR37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for WDR37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000460 maturation of 5.8S rRNA IBA --
GO:0000470 maturation of LSU-rRNA IBA --
genes like me logo Genes that share ontologies with WDR37: view

No data available for Pathways by source and SIGNOR curated interactions for WDR37 Gene

Drugs & Compounds for WDR37 Gene

No Compound Related Data Available

Transcripts for WDR37 Gene

Unigene Clusters for WDR37 Gene

WD repeat domain 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: -
SP11:
SP12:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for WDR37 Gene

GeneLoc Exon Structure for
WDR37
ECgene alternative splicing isoforms for
WDR37

Expression for WDR37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR37 Gene

Protein differential expression in normal tissues from HIPED for WDR37 Gene

This gene is overexpressed in Cervix (20.8), Peripheral blood mononuclear cells (9.4), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR37 Gene



Protein tissue co-expression partners for WDR37 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR37 Gene:

WDR37

SOURCE GeneReport for Unigene cluster for WDR37 Gene:

Hs.188495

Evidence on tissue expression from TISSUES for WDR37 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with WDR37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR37 Gene

Orthologs for WDR37 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR37 34 35
  • 99.8 (n)
oppossum
(Monodelphis domestica)
Mammalia WDR37 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR37 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR37 34 35
  • 87.99 (n)
mouse
(Mus musculus)
Mammalia Wdr37 34 16 35
  • 87.92 (n)
rat
(Rattus norvegicus)
Mammalia Wdr37 34
  • 87.84 (n)
cow
(Bos Taurus)
Mammalia WDR37 34 35
  • 86.3 (n)
chicken
(Gallus gallus)
Aves WDR37 34 35
  • 79.28 (n)
lizard
(Anolis carolinensis)
Reptilia WDR37 35
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr37 34
  • 76.79 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr37 34 35
  • 74.63 (n)
Dr.7221 34
fruit fly
(Drosophila melanogaster)
Insecta CG12333 34 35
  • 57.68 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004374 34
  • 55.18 (n)
worm
(Caenorhabditis elegans)
Secernentea C05D2.10 34 35
  • 51.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for WDR37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR37 Gene

ENSEMBL:
Gene Tree for WDR37 (if available)
TreeFam:
Gene Tree for WDR37 (if available)

Paralogs for WDR37 Gene

Paralogs for WDR37 Gene

(1) SIMAP similar genes for WDR37 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR37: view

Variants for WDR37 Gene

Sequence variations from dbSNP and Humsavar for WDR37 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000045348 -- 1,077,018(+) AAAAG(C/G/T)TAAGT intron-variant
rs1000047493 -- 1,074,719(+) AGTGT(A/G)GAGTG intron-variant
rs1000072887 -- 1,068,734(+) AAGCA(A/G)TTCTG intron-variant
rs1000119451 -- 1,080,169(+) ATTTA(A/G)TGAAG intron-variant
rs1000124905 -- 1,105,529(+) GGGTG(A/G)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR37 Gene

Variant ID Type Subtype PubMed ID
esv1009406 CNV deletion 20482838
esv1356116 CNV deletion 17803354
esv2573324 CNV deletion 19546169
esv2660097 CNV deletion 23128226
esv2662183 CNV deletion 23128226
esv2729406 CNV deletion 23290073
esv2729417 CNV deletion 23290073
esv2729428 CNV deletion 23290073
esv2729439 CNV deletion 23290073
esv3622096 CNV gain 21293372
esv3891735 CNV gain 25118596
nsv1041498 CNV gain 25217958
nsv1046220 CNV gain 25217958
nsv1054432 CNV gain 25217958
nsv1161922 CNV duplication 26073780
nsv476445 CNV novel sequence insertion 20440878
nsv521885 CNV loss 19592680
nsv549765 CNV gain 21841781
nsv549768 CNV gain 21841781
nsv951232 CNV duplication 24416366

Variation tolerance for WDR37 Gene

Residual Variation Intolerance Score: 4.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
WDR37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR37 Gene

Disorders for WDR37 Gene

Relevant External Links for WDR37

Genetic Association Database (GAD)
WDR37
Human Genome Epidemiology (HuGE) Navigator
WDR37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR37

No disorders were found for WDR37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR37 Gene

Publications for WDR37 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 46 64
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for WDR37 Gene

Sources for WDR37 Gene

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