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Aliases for WDR37 Gene

Aliases for WDR37 Gene

  • WD Repeat Domain 37 2 3 5
  • KIAA0982 4

External Ids for WDR37 Gene

Previous GeneCards Identifiers for WDR37 Gene

  • GC10P001056
  • GC10P001085
  • GC10P001092
  • GC10P001041
  • GC10P001095

Summaries for WDR37 Gene

Entrez Gene Summary for WDR37 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR37 Gene

WDR37 (WD Repeat Domain 37) is a Protein Coding gene. An important paralog of this gene is WDR12.

Gene Wiki entry for WDR37 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR37 Gene

Genomics for WDR37 Gene

Regulatory Elements for WDR37 Gene

Enhancers for WDR37 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around WDR37 on UCSC Golden Path with GeneCards custom track

Genomic Location for WDR37 Gene

Chromosome:
10
Start:
1,049,538 bp from pter
End:
1,132,297 bp from pter
Size:
82,760 bases
Orientation:
Plus strand

Genomic View for WDR37 Gene

Genes around WDR37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR37 Gene

Proteins for WDR37 Gene

  • Protein details for WDR37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I8-WDR37_HUMAN
    Recommended name:
    WD repeat-containing protein 37
    Protein Accession:
    Q9Y2I8
    Secondary Accessions:
    • A8K976
    • D3DRQ7
    • Q5SW03
    • Q8WVG2
    • Q9NTJ6

    Protein attributes for WDR37 Gene

    Size:
    494 amino acids
    Molecular mass:
    54665 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76826.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for WDR37 Gene

Proteomics data for WDR37 Gene at MOPED

Post-translational modifications for WDR37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for WDR37 Gene

No data available for DME Specific Peptides for WDR37 Gene

Domains & Families for WDR37 Gene

Gene Families for WDR37 Gene

Suggested Antigen Peptide Sequences for WDR37 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2I8

UniProtKB/Swiss-Prot:

WDR37_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with WDR37: view

Function for WDR37 Gene

genes like me logo Genes that share phenotypes with WDR37: view

Animal Models for WDR37 Gene

MGI Knock Outs for WDR37:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WDR37 Gene

Localization for WDR37 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR37 Gene COMPARTMENTS Subcellular localization image for WDR37 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for WDR37 Gene

Pathways & Interactions for WDR37 Gene

SuperPathways for WDR37 Gene

No Data Available

Interacting Proteins for WDR37 Gene

Gene Ontology (GO) - Biological Process for WDR37 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for WDR37 Gene

Drugs & Compounds for WDR37 Gene

No Compound Related Data Available

Transcripts for WDR37 Gene

Unigene Clusters for WDR37 Gene

WD repeat domain 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - - - -
SP5: - - -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9: -
SP10: -
SP11:
SP12:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for WDR37 Gene

GeneLoc Exon Structure for
WDR37
ECgene alternative splicing isoforms for
WDR37

Expression for WDR37 Gene

mRNA expression in normal human tissues for WDR37 Gene

Protein differential expression in normal tissues from HIPED for WDR37 Gene

This gene is overexpressed in Cervix (20.8), Peripheral blood mononuclear cells (9.4), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for WDR37 Gene



SOURCE GeneReport for Unigene cluster for WDR37 Gene Hs.188495

genes like me logo Genes that share expression patterns with WDR37: view

Protein tissue co-expression partners for WDR37 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR37 Gene

Orthologs for WDR37 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for WDR37 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia WDR37 35
  • 86.3 (n)
  • 95.34 (a)
WDR37 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR37 35
  • 87.99 (n)
  • 95.34 (a)
WDR37 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr37 35
  • 87.92 (n)
  • 96.96 (a)
Wdr37 16
Wdr37 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia WDR37 35
  • 99.8 (n)
  • 99.8 (a)
WDR37 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr37 35
  • 87.84 (n)
  • 97.09 (a)
oppossum
(Monodelphis domestica)
Mammalia WDR37 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR37 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves WDR37 35
  • 79.28 (n)
  • 93.93 (a)
WDR37 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR37 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr37 35
  • 76.79 (n)
  • 91.5 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.7221 35
wdr37 35
  • 74.63 (n)
  • 84.01 (a)
wdr37 36
  • 84 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004374 35
  • 55.18 (n)
  • 55.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12333 35
  • 57.68 (n)
  • 57.04 (a)
CG12333 36
  • 47 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05D2.10 35
  • 51.71 (n)
  • 48.29 (a)
C05D2.10 36
  • 39 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTM1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for WDR37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR37 Gene

ENSEMBL:
Gene Tree for WDR37 (if available)
TreeFam:
Gene Tree for WDR37 (if available)

Paralogs for WDR37 Gene

Paralogs for WDR37 Gene

(1) SIMAP similar genes for WDR37 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with WDR37: view

Variants for WDR37 Gene

Sequence variations from dbSNP and Humsavar for WDR37 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2306407 - 1,096,193(-) CCAGA(C/T)ATGAG reference, missense
rs17856557 - 1,072,186(+) CGACT(A/G)CTCGC reference, missense
rs17856556 - 1,096,181(+) GAGAT(A/C)AGACT reference, missense
rs13909 -- 1,131,933(-) AAACT(A/G)ATGAG utr-variant-3-prime
rs1871625 -- 1,087,688(+) gttcc(A/T)tttat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for WDR37 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
dgv589n71 CNV Loss 21882294
nsv894724 CNV Loss 21882294
nsv894725 CNV Gain 21882294
nsv521885 CNV Loss 19592680
esv2729406 CNV Deletion 23290073
esv2662183 CNV Deletion 23128226
esv2729417 CNV Deletion 23290073
esv2729428 CNV Deletion 23290073
dgv590n71 CNV Loss 21882294
esv2573324 CNV Deletion 19546169
esv2729439 CNV Deletion 23290073
esv1009406 CNV Deletion 20482838
esv1356116 CNV Deletion 17803354

Variation tolerance for WDR37 Gene

Residual Variation Intolerance Score: 4.97% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for WDR37 Gene

Disorders for WDR37 Gene

Relevant External Links for WDR37

Genetic Association Database (GAD)
WDR37
Human Genome Epidemiology (HuGE) Navigator
WDR37
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
WDR37

No disorders were found for WDR37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WDR37 Gene

Publications for WDR37 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila J.L. … Boerwinkle E. (Pharmacogenomics J. 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for WDR37 Gene

Sources for WDR37 Gene

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