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WDR37 Gene

protein-coding GIFtS: 50

GC10P001085

WD repeat domain 37
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ40354 ^²
KIAA0982 ^¹, ², ³
OTTHUMP00000018956 ^²
OTTHUMP00000018957 ^²
RP11-529L18.2 ^²

Descriptions
WD repeat domain 37 ^²

External Ids
HGNC: 31406¹
Entrez Gene: 22884²
UniProtKB: Q9Y2I8³
Ensembl: ENSG00000047056⁷

Search outside databases for aliases for WDR37 gene

Previous GC identifer: GC10P001056

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR37:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved

regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which

may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are

involved in a variety of cellular processes, including cell cycle progression, signal

transduction, apoptosis, and gene regulation. [provided by RefSeq]

Gene Wiki entry for WDR37

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR37 gene

Entrez Gene cytogenetic band: 10p15.3 Ensembl cytogenetic band: 10p15.3 HGNC cytogenetic band: 10p15.3

WDR37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P001085: (about GC identifiers)

Start:	1,085,478 bp from pter
End:	1,168,237 bp from pter
Size:	82,760 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_077567.3

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR37_HUMAN, Q9Y2I8 (See protein sequence)

Recommended Name: WD repeat-containing protein 37

Size: 494 amino acids; 54665 Da

Secondary accessions: Q5SW03 Q9NTJ6

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_054742.2

ENSEMBL proteins:

ENSP00000370730 ENSP00000350954 ENSP00000263150

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WDR37)
	Human Recombinant Proteins from Abnova (WDR37)

OriGene Purified Recombinant Human Protein: WDR37

Antibodies for WDR37:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (WDR37), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (WDR37)
	Novus Biologicals Antibody for WDR37

Assays for WDR37:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y2I8

ProtoNet protein and cluster: Q9Y2I8

UniProtKB/Swiss-Prot: WDR37_HUMAN, Q9Y2I8

Similarity: Contains 7 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC018044

Applied Biosystems Silencer® siRNAs for WDR37

Sigma-Aldrich siRNA for WDR37

Sigma-Aldrich shRNA for WDR37

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_014023
Myc/DDK tagged cDNA clone in CMV expression vector: NM_014023
untagged cDNA clones in CMV expression vector (see all 2): BC018044

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_014023

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for WDR37 (Q9Y2I8²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
SFN P31947² MINT-3976543
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR37

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR37)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC018044

Sigma-Aldrich siRNA for WDR37

Sigma-Aldrich shRNA for WDR37

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014023

REFSEQ mRNAs for WDR37 gene:

NM_014023.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014023

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014023
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_014023
                                 untagged cDNA clones in CMV expression vector (see all 2): BC018044

Additional cDNA sequence:

AB023199.1 AK024605.1 AK097673.1 AK292591.1 AK307259.1 AL136827.1 BC018044.1 BC046195.1

BC133038.1 BC133040.1

18 DOTS entries:

DT.100744756 DT.121257305 DT.92423348 DT.97817348 DT.121257167 DT.101961628 DT.99954241 DT.91953431

DT.95073110 DT.101957837 DT.121257197 DT.121257335 DT.86843284 DT.91888552 DT.91892985 DT.95255026

DT.95328649 DT.97815776

24/126 AceView cDNA sequences (see all 126 ):

BE669681 CK822348 AW592361 AI147703 AA017342 BE813532 C18387 C01597

Z42698 AI421861 AI131459 NM_014023 F06159 AA700843 BE551396 AK024605

AI422844 AI862319 BM667332 Z38858 CA976047 AW295951 CB216081 AI671988

highest scoring ESTs for WDR37:

AB023199 AA010290 AA010291 AA017133 AA460435 AA460436 AA812976 AA824261 AA844641 AA926645

Unigene Cluster for WDR37:

WD repeat domain 37

Hs.188495 [show with all ESTs]

Unigene Representative Sequence: NM_014023

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for WDR37 (see all 12 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^
SP1:			-		-		-		-		-		-		-						-		-		-				-																		-		-		-
SP2:					-		-		-		-		-		-						-		-		-				-
SP3:																					-				-				-
SP4:																					-		-		-				-
SP5:																																															-		-		-

ExUns:	15a	·	15b	^	16a	·	16b	^	17a	·	17b	^	18a	·	18b	·	18c	^	19
SP1:									-
SP2:
SP3:
SP4:
SP5:									-

About this scheme

ECgene alternative splicing isoforms for WDR37

3 Ensembl transcripts including schematic representations:

ENST00000381329 ENST00000358220 ENST00000263150

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR37 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR37

¹ / ² / ³

4 probe-sets matching WDR37 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35199_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB023199	1.00	0.90	0.95	1
211383_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL136827	0.80	0.88	0.84	1
1554869_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211383_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR37 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.188495
Expression variation in blood from EXPOLDB for WDR37

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR37 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR37¹	--	WD repeat domain 37	87.99(n) 95.34(a)	607652 XM_844325.1 XP_849418.1
chimpanzee (Pan troglodytes)	WDR37¹	--	WD repeat domain 37	99.8(n) 99.8(a)	465999 XM_001137901.1 XP_001137901.1
cow (Bos taurus)	WDR37¹	--	WD repeat domain 37	86.3(n) 95.34(a)	529876 XM_608337.3 XP_608337.3
rat (Rattus norvegicus)	Wdr37¹	--	WD repeat domain 37	85.36(n) 92.58(a)	307075 XM_225512.4 XP_225512.4
mouse (Mus musculus)	Wdr37^{1, 5}	13⁵	WD repeat domain 37^{1, 5}	87.92(n)¹ 96.96(a)¹	207615¹ NM_172445.2¹ NP_766033.1¹ AA231297⁵ AA882313⁵ (see all 22)

About this table Species with no ortholog for WDR37

ENSEMBL Gene Tree for WDR37

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR37 gene

COPB2² COPA²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/479 NCBI SNPs in WDR37 are shown (see all 479 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 158)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs12359210^1,2	A,C,F,H	1165939(+)	`TCTCCC/TGAGGT`	1	--	ut3¹ ese³		8		EU EA WA	824
--	rs4880475^1,2	A,C	1168673(+)	`GGCTGA/GGGCTG`	1	--	ng3¹		0	--	--	--	--
	rs4880772^1,2	F,H	1165546(+)	`ACATGA/GAATGC`	1	--	ut3¹ ese³		4		EU EA WA	396
--	rs13909^1,2	F	1167873(-)	`AAACTG/AATGAG`	1	--	ut3¹		1		MN	184
--	rs17856557^1,2	H	1108126(+)	`CGACTG/ACTCGC`	1	T/A	mis¹ ese³		4		EU EA WA	412
	rs2306407^1,2	H	1132133(-)	`CCAGAT/CATGAG`	1	V/I	mis¹ ese³		4		EU EA WA	418
--	rs17856556^1,2	H	1132121(+)	`GAGATC/AAGACT`	1	K/Q	mis¹ ese³		4		EU EA WA	420
	rs7074721^1,2	A,C,F,H	1118216(+)	`AGCAAA/GTAACG`	1	--	int¹		10		NA EU EA WA	832
--	rs4880770^1,2	A,C,F,H	1163670(+)	`CACGGG/AGTGTG`	1	--	int¹		4		EU EA WA	420
	rs7087381^1,2	A,C,F,H	1116293(+)	`ATTTGT/CGAGGC`	1	--	int¹		7		EU EA WA NA	556

About this table

HapMap Linkage Disequilibrium images for WDR37 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for WDR37 gene:

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{2, 3, 4} Wiemann S.... Poustka A. (2001)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{2, 3, 4} Nagase T....Ohara O. (1999)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{3, 4} Deloukas P.... Rogers J. (2004)
The LIFEdb database in 2006. (PubMed id 16381901)³ Mehrle A....Wiemann S. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)³ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)³ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 22884	HGNC: 31406	AceView: WDR37	Ensembl:ENSG00000047056	euGenes: HUgn22884
ECgene: WDR37	H-InvDB: WDR37

(According to HUGE)
About This Section

HUGE: KIAA0982

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR37
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for WDR37:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR37-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR37		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR37		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for WDR37

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for WDR37

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WDR37 Gene

protein-coding GIFtS: 50

Aliases &
Descriptions
for WDR37

Summaries
for WDR37

Genomic Location
for WDR37

Proteins
for WDR37

Protein Domains/
Families
for WDR37

Gene Function
for WDR37

Pathways & Interactions
for WDR37

Drugs & Compounds
for WDR37

Transcripts
for WDR37

Expression
for WDR37

Orthologs
for WDR37

Paralogs
for WDR37

SNPs/Variants
for WDR37

Disorders & Mutations
for WDR37

Medical News
for WDR37

Publications
for WDR37

Search for WDR37

Genome Databases showing WDR37

Other Databases showing WDR37

Specialized Databases showing WDR37

Licensable Technologies
for WDR37

Services
for WDR37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR37 Gene

protein-coding GIFtS: 50

Aliases & Descriptionsfor WDR37

Summariesfor WDR37

Genomic Locationfor WDR37

Proteinsfor WDR37

Protein Domains/Familiesfor WDR37

Gene Functionfor WDR37

Pathways & Interactionsfor WDR37

Drugs & Compoundsfor WDR37

Transcriptsfor WDR37

Expression for WDR37

Orthologsfor WDR37

Paralogsfor WDR37

SNPs/Variantsfor WDR37

Disorders & Mutationsfor WDR37

Medical Newsfor WDR37

Publicationsfor WDR37

Search for WDR37

Genome Databases showing WDR37

Other Databases showing WDR37

Specialized Databases showing WDR37

Licensable Technologiesfor WDR37

Servicesfor WDR37

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR37

Summaries
for WDR37

Genomic Location
for WDR37

Proteins
for WDR37

Protein Domains/
Families
for WDR37

Gene Function
for WDR37

Pathways & Interactions
for WDR37

Drugs & Compounds
for WDR37

Transcripts
for WDR37

Expression
for WDR37

Orthologs
for WDR37

Paralogs
for WDR37

SNPs/Variants
for WDR37

Disorders & Mutations
for WDR37

Medical News
for WDR37

Publications
for WDR37

Licensable Technologies
for WDR37

Services
for WDR37