V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

WDR36 Gene

protein-coding   GIFtS: 57

GC05P110455
WD repeat domain 36
(Previous names: glaucoma 1, open angle, G )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GLC1G)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp686I1650 2
GLC1G 2, 5
OTTHUMP00000158997 2
TA-WDRP 1, 2, 3
TAWDRP 2, 5
UTP21 1, 2
Descriptions
T-cell activation WD repeat protein 2
T-cell activation WD repeat-containing protein 3
WD repeat domain 36 2
glaucoma 1, open angle, G 1
External Ids
HGNC: 306961
Entrez Gene: 1344302
UniProtKB: Q8NI363
Ensembl: ENSG000001349877
Search outside databases for aliases for WDR36 gene

Previous GC identifer: GC05P110505

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR36:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with
adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq]

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Function: Involved in T cell activation and highly co-regulated with IL2

Gene Wiki entry for WDR36

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR36 gene  

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.2

WDR36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110455:     (about GC identifiers)

Start:
110,455,769 bp from pter
End:
110,494,099 bp from pter
Size:
38,331 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_034772.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36 (See protein sequence)
Recommended Name: WD repeat-containing protein 36  
Size: 951 amino acids; 105322 Da
Secondary accessions: A2RUS4 Q8N1Q2

REFSEQ proteins: NP_644810.1  

ENSEMBL proteins: 
ENSP00000319771 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (WDR36)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005575 cellular_component ND--
GO:0032040 small-subunit processome IEA--
About this table

Antibodies for WDR36: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for WDR36
Browse R&D Systems for Antibodies
Antibodies from Abcam (WDR36), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (WDR36)
Novus Biologicals Antibodies for WDR36

Assays for WDR36: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR001680 WD40_repeat
 IPR007319 SSU_processome_Utp21


   GeneDecks  WDR36 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8NI36

ProtoNet protein and cluster: Q8NI36

1 Blocks protein family: IPB000873 AMP-binding signature

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Similarity: Contains 9 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR36)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (WDR36)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139281

              Applied Biosystems Silencer® siRNAs for WDR36

              Sigma-Aldrich siRNA for WDR36  
                     Sigma-Aldrich shRNA for WDR36  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_139281
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_139281
                                 untagged cDNA clone in CMV expression vector: NM_139281 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_139281

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Function: Involved in T cell activation and highly co-regulated with IL2

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003674 molecular_function ND--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



5/12 Interacting proteins for WDR36 (ENSP000003197713) via UniProtKB, MINT, and/or STRING (see all 12 )
InteractantInteraction Details
GeneCardExternal ID(s)
OPTNENSP000003680223STRING (score=.956)
MYOCENSP000000375023STRING (score=.946)
RCHY1ENSP000003212393STRING (score=.862)
EFNA5ENSP000003287773STRING (score=.794)
EMG1ENSP000002614063STRING (score=.785)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006364 rRNA processing IEA--
GO:0007601 visual perception IEA--
GO:0050896 response to stimulus IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR36

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (WDR36)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (WDR36)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139281

              Sigma-Aldrich siRNA for WDR36  
                     Sigma-Aldrich shRNA for WDR36  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_139281  

REFSEQ mRNAs for WDR36 gene: 

NM_139281.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_139281  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_139281
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_139281
                                 untagged cDNA clone in CMV expression vector: NM_139281 

Additional cDNA sequence: 

AF385437.1 AK055664.1 AK074202.1 AK095312.1 AL832494.1 BC037427.1 BC133025.1 BC136517.1 
CR600030.1 CR749211.1 

6 DOTS entries:

DT.100024414  DT.95266600  DT.441426  DT.120828713  DT.102830676  DT.40122924 

24/154 AceView cDNA sequences (see all 154 ):

AU185710 BM453755 AA770692 AF385437 AK095312 AI452987 AA442593 AK055664 
BP365899 BQ420958 N28000 CD514861 BM129741 BQ231864 AA768963 CK819663 
AA827623 BF056935 AI695924 W74458 CB243764 AA805260 AA039378 NM_139281 

highest scoring ESTs for WDR36:

AI655936 AA039378 AA039379 AA043752 AA043753 AA057286 AA057301 AA235034 AA235103 AA235202 

Unigene Cluster for WDR36:

WD repeat domain 36
Hs.533237  [show with all ESTs]
Unigene Representative Sequence: NM_139281


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR36

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1:              -                                                                                                                                             
SP2:        -     -                                                                                                                       -                     
SP3:                                                                                                                                                            

About this scheme

ECgene alternative splicing isoforms for WDR36

1 Ensembl transcript including schematic representation:
ENST00000323652  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR36 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR36

1 / 2 / 3

8 probe-sets matching WDR36 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
45128_at2, 3 U95-B 1 1.00 1.00 0.85 1.10 W20061 0.80 1.00 0.91 1

47877_at2, 3 U95-B 1 1.00 1.00 0.79 0.93 AI655936 1.00 1.00 1.00 1

81311_at2, 3 U95-E 1 0.94 1.00 0.80 1.26 AA827623 0.80 1.00 0.91 1

85806_at2, 3 U95-D 1 0.94 1.00 0.77 0.71 AW025914 0.80 1.00 0.91 1

238677_at2, 3 U133-B 1 1.00 1.00 -- -- AA235202 0.80 1.00 0.91 1

226180_at2, 3 U133-B 1 1.00 1.00 -- -- BF439595 0.80 1.00 0.91 1

238677_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226180_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  WDR36 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTGTCTGTTT

SOURCE GeneReport for Unigene cluster: Hs.533237

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In
ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic
nerve

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for WDR36 gene from 5/21 species (see all 21 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
WDR361   -- WD repeat domain 36 91.54(n)
92.36(a)
488875  XM_545992.2  XP_545992.2 
chimpanzee
(Pan troglodytes)
WDR361   -- WD repeat domain 36 99.51(n)
99.47(a)
461989  XM_517870.2  XP_517870.2 
cow
(Bos taurus)
WDR361   -- WD repeat domain 36 90.65(n)
92.51(a)
514267  XM_592093.3  XP_592093.2 
rat
(Rattus norvegicus)
LOC6886371   -- similar to WD repeat domain 36 86.42(n)
89.3(a)
688637  XM_001067706.1  XP_001067706.1 
mouse
(Mus musculus)
Wdr365 18 WD repeat domain 36   -- BP767184 
About this table        Species with no ortholog for WDR36

ENSEMBL Gene Tree for WDR36
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/232 NCBI SNPs in WDR36 are shown (see all 232 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 132)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs112410951,2
A,C,F,H110467408(+) TTGCTA/GTTGGT 1 I/V mis1 ese313Minor allele frequency- N:0.01EA NA EU WA 1122
rs77238191,2
A,C,F,H110455246(+) TGCCCG/AGACTC 1 -- ng5110Minor allele frequency- A:0.42MN EA EU WA 2090
rs10438281,2
A,C,F,H110491907(+) TAATAT/CTCATG 1 -- ut318Minor allele frequency- C:0.19MN EU EA WA NA 746
rs119480891,2
A,C,F,H110492292(+) GATAGA/TATACA 1 -- ut314Minor allele frequency- T:0.18EU EA WA 412
rs119568371,2
C,F,H110482656(+) TTTCTA/GTGTCT 1 M/V mis1 ese39Minor allele frequency- G:0.03EU EA WA NA 914
--
rs100508341,2
A,C,F110455227(+) GCACTC/TAGCTC 1 -- ng512Minor allele frequency- T:0.38MN EA 1252
rs2527131,2
C,F,H110455000(+) AAAACA/GTTTTC 1 -- ng5112Minor allele frequency- G:0.03EU EA WA 1258
--
rs125231211,2
A,C110454087(+) ctgccA/Gccttg 1 -- ng510--------
rs119545341,2
C,F110492221(+) TGAACC/TGAATT 1 -- ut31 ese33Minor allele frequency- T:0.13NA 142
rs68594541,2
F,H110493582(+) AAATTC/GTTTCA 1 -- ut314Minor allele frequency- G:0.01EU EA WA 420
About this table

HapMap Linkage Disequilibrium images for WDR36 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609669   disorders: 609887  

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36

  • Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G)
    [MIM:609887]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic
    nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually
    the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which
    time significant and irreversible optic nerve damage has already taken place
  • 2 Novoseek disease relationships for WDR36 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    glaucoma open-angle 84.24 10 16723468 (2), 19347049 (2), 17960130 (2), 16966629 (2) (see all 6)
    glaucoma 73.90 9 16876519 (2), 16723468 (1), 16877390 (1), 17563717 (1) (see all 6)
    About this table

    Human Gene Mutation Database: WDR36
    Human Genome Epidemiology Navigator: WDR36 (10 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/23 PubMed articles for WDR36 gene (see all 23 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 134430 HGNC: 30696 AceView: WDR36 Ensembl:ENSG00000134987 euGenes: HUgn134430
    ECgene: WDR36 H-InvDB: WDR36
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    GeneReviewshttp://www.genetests.org/query?gene=WDR36
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for WDR36:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR36-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for WDR36 Antibodies for WDR36
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for WDR36 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Antibodies (WDR36)
     Chimera RNAi (WDR36)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (WDR36)
     Antibodies (WDR36)
     Search OriGene for WDR36
     Search Tocris compounds for WDR36




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for WDR36

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    WDR36 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com