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WDR36 Gene

protein-coding   GIFtS: 57
GCID: GC05P110427

WD Repeat Domain 36

(Previous names: glaucoma 1, open angle, G)
(Previous symbol: GLC1G)
  See WDR36-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 361 2     Glaucoma 1, Open Angle, G1
GLC1G1 2 5     UTP212
TA-WDRP2 3     T-Cell Activation WD Repeat Protein2
T-Cell Activation WD Repeat-Containing Protein2 3     WD Repeat-Containing Protein 362
TAWDRP2 5     

External Ids:    HGNC: 306961   Entrez Gene: 1344302   Ensembl: ENSG000001349877   OMIM: 6096695   UniProtKB: Q8NI363   

Export aliases for WDR36 gene to outside databases

Previous GC identifers: GC05P110505 GC05P110455 GC05P105606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR36 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in
this gene have been associated with adult-onset primary open-angle glaucoma (POAG). (provided by RefSeq, Jul
2008)

GeneCards Summary for WDR36 Gene:
WDR36 (WD repeat domain 36) is a protein-coding gene. Diseases associated with WDR36 include primary open angle glaucoma, and glaucoma 1, open angle, g.

UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Function: Involved in T-cell activation and highly coregulated with IL2

Gene Wiki entry for WDR36 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR36 gene promoter:
         POU3F2 (N-Oct-5b)   STAT5A   Egr-2   MEF-2A   POU2F1   POU2F1a   SEF-1 (1)   aMEF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR36 promoter sequence
   Search Chromatin IP Primers for WDR36

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.1   Ensembl cytogenetic band:  5q22.1   HGNC cytogenetic band: 5q22.2

WDR36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR36 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P110427:  view genomic region     (about GC identifiers)

Start:
110,427,414 bp from pter      End:
110,466,200 bp from pter
Size:
38,787 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36 (See protein sequence)
Recommended Name: WD repeat-containing protein 36  
Size: 951 amino acids; 105322 Da
Sequence caution: Sequence=BAC04527.1; Type=Erroneous initiation;
Secondary accessions: A2RUS4 Q8N1Q2

Explore the universe of human proteins at neXtProt for WDR36: NX_Q8NI36

Explore proteomics data for WDR36 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys284, Lys413, Lys446, Lys814, Lys824, Lys839
  • Modification sites at PhosphoSitePlus

  • See WDR36 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_644810.1  
    ENSEMBL proteins: 
     ENSP00000423067   ENSP00000424628   ENSP00000422158   ENSP00000426509  

    WDR36 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR007319 SSU_processome_Utp21
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NI36

    ProtoNet protein and cluster: Q8NI36

    1 Blocks protein domain: IPB000873 AMP-binding signature

    UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
    Similarity: Contains 9 WD repeats


    Find genes that share domains with WDR36           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR36_HUMAN, Q8NI36
    Function: Involved in T-cell activation and highly coregulated with IL2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with WDR36           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for WDR36:
     Decreased homologous recombina  Increased gamma-H2AX phosphory  Nuclear 40S maturation defects  Nucleolar pre-40S maturation d 
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Wdr36):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with WDR36           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for WDR36
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for WDR36

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR36
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for WDR36

    miRNA
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    miRTarBase miRNAs that target WDR36:
    hsa-mir-361-5p (MIRT020085), hsa-mir-193b-3p (MIRT041461)

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    Selected qRT-PCR Assays for microRNAs that regulate WDR36 (see all 11):
    hsa-miR-498 hsa-miR-607 hsa-miR-130a* hsa-miR-23c hsa-miR-3647-3p hsa-miR-23b hsa-miR-3613-3p hsa-miR-205*
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR36


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR36_HUMAN, Q8NI36: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005730nucleolus IEA--
    GO:0032040small-subunit processome IEA--

    Find genes that share ontologies with WDR36           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for WDR36 About    
    See pathways by source

    SuperPathContained pathways About
    1Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with WDR36           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for WDR36):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR36
    Interactions:

        Search GeneGlobe Interaction Network for WDR36

    Selected Interacting proteins for WDR36 (Q8NI363) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001895retina homeostasis IEA--
    GO:0006364rRNA processing IEA--
    GO:0007601visual perception IEA--
    GO:0008150biological_process ND--
    GO:0030516regulation of axon extension IEA--

    Find genes that share ontologies with WDR36           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for WDR36



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR36 gene: 
    NM_139281.2  

    Unigene Cluster for WDR36:

    WD repeat domain 36
    Hs.533237  [show with all ESTs]
    Unigene Representative Sequence: NM_139281
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506538(uc003kpd.3 uc010jbu.3) ENST00000513710 ENST00000505303
    ENST00000515784 ENST00000504122
    miRNA
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    Block miRNA regulation of human, mouse, rat WDR36 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate WDR36 (see all 11):
    hsa-miR-498 hsa-miR-607 hsa-miR-130a* hsa-miR-23c hsa-miR-3647-3p hsa-miR-23b hsa-miR-3613-3p hsa-miR-205*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: WDR36 (NM_139281)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR36
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat WDR36
      QuantiFast Probe-based Assays in human, mouse, rat WDR36

    Additional mRNA sequence: 

    AF385437.1 AK055664.1 AK074202.1 AK095312.1 AL832494.1 BC037427.1 BC133025.1 BC136517.1 
    CR749211.1 

    6 DOTS entries:

    DT.100024414  DT.95266600  DT.441426  DT.120828713  DT.102830676  DT.40122924 

    Selected AceView cDNA sequences (see all 154):

    CK819663 N28000 AK055664 CD636847 AA768963 AI452987 AA827623 CA429633 
    CA438568 CR600030 BF056935 AF385437 AU185710 BX110480 CB243764 AA039378 
    AI695924 CD514861 BX112836 AK095312 AA770692 BM453755 AA805260 BM129741 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR36    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
    SP1:              -                                                                                                                                             
    SP2:        -     -                                                                                                                       -                     
    SP3:                                                                                                                                                            


    ECgene alternative splicing isoforms for WDR36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR36 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCTGTTT
    WDR36 Expression
    About this image

    WDR36 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR36 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533237

    UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
    Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues,
    strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for WDR36 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr361 , 5 WD repeat domain 361, 5 86.85(n)1
    88.85(a)1
      18 (18.13 cM)5
    2253481  NM_001110015.11  NP_001103485.11 
     328372255 
    chicken
    (Gallus gallus)
    Aves WDR361 WD repeat domain 36 73.25(n)
    73.93(a)
      415609  NM_001044634.1  NP_001038099.1 
    lizard
    (Anolis carolinensis)
    Reptilia WDR366
    WD repeat domain 36
    72(a)
    1 ↔ 1
    GL343193.1(6226539-6281609)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC531822 similar to T-cell activation WD repeat protein 74.61(n)    BC047972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb33e102 wufb33e10 75.16(n)   321745  BC057514.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97991 CG9799 48.3(n)
    40.5(a)
      41647  NM_142027.4  NP_650284.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y45F10D.76
    Protein Y45F10D.7 (Y45F10D.7) mRNA, complete cds
    28(a)
    1 ↔ 1
    IV(13788936-13796224) WBGene00012887
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UTP211 UTP21 46.33(n)
    34.42(a)
      851125   NP_013513.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G049401 AT4G04940 48.31(n)
    39.72(a)
      825833  NM_116732.2  NP_567275.1 


    ENSEMBL Gene Tree for WDR36 (if available)
    TreeFam Gene Tree for WDR36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR36 gene
    1 SIMAP similar gene for WDR36 using alignment to 3 protein entries:     WDR36_HUMAN (see all proteins):
    DKFZp686I1650

    Find genes that share paralogs with WDR36           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR36 (see all 1089)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357036381,2,,4
    C,FGlaucoma 1, open angle, G (GLC1G)4 pathogenic1110723019(-) ACCTGC/TTGCAA 2 T A mis14Minor allele frequency- T:0.00NA EU 5917
    rs1165298821,2,,4
    C,FGlaucoma 1, open angle, G (GLC1G)4 pathogenic1110727159(+) ACATCG/AAGGAA 2 /Q /R mis13Minor allele frequency- A:0.00NA EU 5983
    rs345952521,2,,4
    C,FGlaucoma 1, open angle, G (GLC1G)4 pathogenic1110735900(-) AGCAGT/CCTATA 2 /D /G mis14Minor allele frequency- C:0.01NA EU 5945
    VAR_0259664
    Glaucoma 1, open angle, G (GLC1G)4--see VAR_0259662 N S mis40--------
    rs1182040221,2
    Cpathogenic1110721221(+) TGACAA/GTGCTC 2 N S mis11Minor allele frequency- G:0.00NA 4496
    rs100455771,2
    C--110426451(+) cggtgC/Tgcgca 1 -- us2k10--------
    rs1125314741,2
    C,F--110432304(+) GGCTGC/AGGCAG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs353390701,2
    C--110438000(+) AAAAAA/-TACAG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs343236141,2
    C--110446455(+) CTGAT-/TTTTTT 1 -- int10--------
    rs100580941,2
    C--110448734(+) taaatA/Tatata 1 -- int10--------

    HapMap Linkage Disequilibrium report for WDR36 (110427414 - 110466200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for WDR36:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519338CNV Gain19592680
    nsv882707CNV Gain21882294

    Human Gene Mutation Database (HGMD): WDR36
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR36
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609669   
    OMIM disorders: 609887  
    UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
  • Glaucoma 1, open angle, G (GLC1G) [MIM:609887]: A form of primary open angle glaucoma (POAG). POAG is
    characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of
    the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any
    intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and
    irreversible optic nerve damage has already taken place. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 5 diseases for WDR36:    
    About MalaCards
    primary open angle glaucoma    glaucoma 1, open angle, g    glaucoma    open-angle glaucoma
    primary congenital glaucoma

    2 diseases from the University of Copenhagen DISEASES database for WDR36:
    Glaucoma     Blindness

    Find genes that share disorders with WDR36           About GenesLikeMe

    2 Novoseek inferred disease relationships for WDR36 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glaucoma open-angle 85.1 10 16723468 (2), 19347049 (2), 17960130 (2), 16966629 (2) (see all 6)
    glaucoma 74.8 9 16876519 (2), 16723468 (1), 16877390 (1), 17563717 (1) (see all 6)

    Genetic Association Database (GAD): WDR36
    Human Genome Epidemiology (HuGE) Navigator: WDR36 (14 documents)

    Export disorders for WDR36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR36 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with WDR36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (PubMed id 15677485)1, 2, 3, 9 Monemi S.... Sarfarazi M. (Hum. Mol. Genet. 2005)
    2. Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. (PubMed id 16723468)1, 4, 9 Hauser M.A....Wiggs J.L. (amp 2006)
    3. Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma. (PubMed id 19347049)1, 4, 9 Fan B.J....Pang C.P. (Mol. Vis. 2009)
    4. [Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]. (PubMed id 20198978)1, 4, 9 Motushchuk A.E....Vasil'ev V.B. (Genetika 2009)
    5. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. (PubMed id 19145250)1, 4, 9 Jia L.Y....Wang N.L. (Mol. Vis. 2009)
    6. Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese. (PubMed id 17960130)1, 4, 9 Miyazawa A....Nishida K. (Mol. Vis. 2007)
    7. A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant. (PubMed id 16876519)1, 4, 9 Hewitt A.W....Craig J.E. (Am. J. Ophthalmol. 2006)
    8. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    9. Genetic evidence for a role of IL33 in nasal polyposis. (PubMed id 19860791)1, 4 Buysschaert I.D....Lambrechts D. (Allergy 2010)
    10. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. (PubMed id 20208534)1, 4 Rothenberg M.E....Hakonarson H. (Nat. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 134430 HGNC: 30696 AceView: WDR36 Ensembl:ENSG00000134987 euGenes: HUgn134430
    ECgene: WDR36 Kegg: 134430 H-InvDB: WDR36

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for WDR36 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=WDR36[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR36 gene:
    Search GeneIP for patents involving WDR36

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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