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Aliases for WDR36 Gene

Aliases for WDR36 Gene

  • WD Repeat Domain 36 2 3
  • T-Cell Activation WD Repeat-Containing Protein 3 4
  • TA-WDRP 3 4
  • TAWDRP 3 6
  • GLC1G 3 6
  • T-Cell Activation WD Repeat Protein 3
  • WD Repeat-Containing Protein 36 3
  • Glaucoma 1, Open Angle, G 2
  • UTP21 3

External Ids for WDR36 Gene

Previous Symbols for WDR36 Gene

  • GLC1G

Summaries for WDR36 Gene

Entrez Gene Summary for WDR36 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR36 Gene

WDR36 (WD Repeat Domain 36) is a Protein Coding gene. Diseases associated with WDR36 include glaucoma 1, open angle, g and open-angle glaucoma. Among its related pathways are Ribosome biogenesis in eukaryotes.

UniProtKB/Swiss-Prot for WDR36 Gene

  • Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.

Gene Wiki entry for WDR36 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR36 Gene

Genomics for WDR36 Gene

Genomic Location for WDR36 Gene

Start:
111,091,716 bp from pter
End:
111,130,502 bp from pter
Size:
38,787 bases
Orientation:
Plus strand

Genomic View for WDR36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR36 Gene

Regulatory Elements for WDR36 Gene

Proteins for WDR36 Gene

  • Protein details for WDR36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI36-WDR36_HUMAN
    Recommended name:
    WD repeat-containing protein 36
    Protein Accession:
    Q8NI36
    Secondary Accessions:
    • A2RUS4
    • Q68E02
    • Q8N1Q2

    Protein attributes for WDR36 Gene

    Size:
    951 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Depletion of WDR36 mRNA in cultured cells causes apoptotic cell death and consistently associates with a reduced 21S rRNA and delay of 18S rRNA maturation.
    SequenceCaution:
    • Sequence=BAC04527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR36 Gene

Proteomics data for WDR36 Gene at MOPED

Post-translational modifications for WDR36 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys284, Lys413, Lys446, Lys814, Lys824, and Lys839

Other Protein References for WDR36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR36 Gene

Domains for WDR36 Gene

Gene Families for WDR36 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

WDR36_HUMAN
Domain:
  • The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.:
    • Q8NI36
Similarity:
  • Contains 14 WD repeats.:
    • Q8NI36
genes like me logo Genes that share domains with WDR36: view

Function for WDR36 Gene

Molecular function for WDR36 Gene

UniProtKB/Swiss-Prot Function: Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.

Gene Ontology (GO) - Molecular Function for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR36: view
genes like me logo Genes that share phenotypes with WDR36: view

miRNA for WDR36 Gene

miRTarBase miRNAs that target WDR36

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for WDR36 Gene

Localization for WDR36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR36 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for WDR36 Gene COMPARTMENTS Subcellular localization image for WDR36 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0032040 small-subunit processome IBA --
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome IBA --
genes like me logo Genes that share ontologies with WDR36: view

Pathways for WDR36 Gene

genes like me logo Genes that share pathways with WDR36: view

Pathways by source for WDR36 Gene

1 KEGG pathway for WDR36 Gene

Gene Ontology (GO) - Biological Process for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEA --
GO:0006364 rRNA processing IBA --
GO:0007601 visual perception IEA --
GO:0008150 biological_process ND --
GO:0030516 regulation of axon extension IEA --
genes like me logo Genes that share ontologies with WDR36: view

Transcripts for WDR36 Gene

Unigene Clusters for WDR36 Gene

WD repeat domain 36:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -
SP3:

Relevant External Links for WDR36 Gene

GeneLoc Exon Structure for
WDR36
ECgene alternative splicing isoforms for
WDR36

Expression for WDR36 Gene

mRNA expression in normal human tissues for WDR36 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR36 Gene

SOURCE GeneReport for Unigene cluster for WDR36 Gene Hs.533237

mRNA Expression by UniProt/SwissProt for WDR36 Gene

Q8NI36-WDR36_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.
genes like me logo Genes that share expressions with WDR36: view

Orthologs for WDR36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR36 36
  • 99.51 (n)
  • 99.47 (a)
WDR36 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR36 36
  • 90.65 (n)
  • 92.51 (a)
WDR36 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR36 36
  • 91.54 (n)
  • 92.36 (a)
WDR36 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr36 36
  • 86.85 (n)
  • 88.85 (a)
Wdr36 16
Wdr36 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR36 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR36 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688637 36
  • 86.41 (n)
  • 89.16 (a)
chicken
(Gallus gallus)
Aves WDR36 36
  • 73.25 (n)
  • 73.93 (a)
WDR36 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR36 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53182 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.768 36
wdr36 36
  • 67.72 (n)
  • 69.23 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2846 36
zebrafish
(Danio rerio)
Actinopterygii wdr36 36
  • 65.43 (n)
  • 65.35 (a)
wdr36 37
  • 65 (a)
OneToOne
wufb33e10 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004557 36
  • 49.66 (n)
  • 43.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9799 36
  • 48.3 (n)
  • 40.5 (a)
CG9799 37
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y45F10D.7 37
  • 28 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER081C 36
  • 45.46 (n)
  • 35.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP21 36
  • 46.33 (n)
  • 34.42 (a)
UTP21 37
  • 31 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02827g 36
  • 46.42 (n)
  • 34.93 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04940 36
  • 48.31 (n)
  • 39.72 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07011 36
  • 43.82 (n)
  • 34.79 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.07 36
  • 47.71 (n)
  • 37.3 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11006 36
Species with no ortholog for WDR36:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR36 Gene

ENSEMBL:
Gene Tree for WDR36 (if available)
TreeFam:
Gene Tree for WDR36 (if available)

Paralogs for WDR36 Gene

Selected SIMAP similar genes for WDR36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR36: view

No data available for Paralogs for WDR36 Gene

Variants for WDR36 Gene

Sequence variations from dbSNP and Humsavar for WDR36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs43203 -- 111,122,285(+) GAGCA(A/G)AGTTT intron-variant
rs252708 -- 111,101,735(+) TAAAT(C/T)AGTGT intron-variant
rs252713 -- 111,091,403(+) AAAAC(A/G)TTTTC upstream-variant-2KB
rs252714 -- 111,091,037(+) AATAC(A/T)AGTAA upstream-variant-2KB
rs252715 -- 111,090,775(+) gcgcc(A/C/G/T)actgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for WDR36 Gene

Variant ID Type Subtype PubMed ID
nsv519338 CNV Gain 19592680
nsv882707 CNV Gain 21882294

Relevant External Links for WDR36 Gene

HapMap Linkage Disequilibrium report
WDR36
Human Gene Mutation Database (HGMD)
WDR36

Disorders for WDR36 Gene

(1) OMIM Diseases for WDR36 Gene (609669)

UniProtKB/Swiss-Prot

WDR36_HUMAN
  • Glaucoma 1, open angle, G (GLC1G) [MIM:609887]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:15677485}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for WDR36 Gene

(2) Novoseek inferred disease relationships for WDR36 Gene

Disease -log(P) Hits PubMed IDs
glaucoma open-angle 85.1 10
glaucoma 74.8 7

Relevant External Links for WDR36

Genetic Association Database (GAD)
WDR36
Human Genome Epidemiology (HuGE) Navigator
WDR36
genes like me logo Genes that share disorders with WDR36: view

Publications for WDR36 Gene

  1. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (PMID: 15677485) Monemi S. … Sarfarazi M. (Hum. Mol. Genet. 2005) 2 3 4 23
  2. Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. (PMID: 16723468) Hauser M.A. … Wiggs J.L. (Invest. Ophthalmol. Vis. Sci. 2006) 3 23 49
  3. A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant. (PMID: 16876519) Hewitt A.W. … Craig J.E. (Am. J. Ophthalmol. 2006) 3 23 49
  4. Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese. (PMID: 17960130) Miyazawa A. … Nishida K. (Mol. Vis. 2007) 3 23 49
  5. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. (PMID: 19145250) Jia L.Y. … Wang N.L. (Mol. Vis. 2009) 3 23 49

Products for WDR36 Gene

Sources for WDR36 Gene

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