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Aliases & Descriptions for WDR36
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZp686I1650 2 | | GLC1G 2, 5 | | OTTHUMP00000158997 2 | | TA-WDRP 1, 2, 3 | | TAWDRP 2, 5 | | UTP21 1, 2 |
| | | Descriptions |
|---|
| T-cell activation WD repeat protein 2 | | T-cell activation WD repeat-containing protein 3 | | WD repeat domain 36 2 | | glaucoma 1, open angle, G 1 |
|
| | Search outside databases for aliases for WDR36 genePrevious GC identifer: GC05P110505 |
Summaries for WDR36(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for WDR36: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq] UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36Function: Involved in T cell activation and highly co-regulated with IL2Gene Wiki entry for WDR36 |
Genomic Location for WDR36
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the WDR36 gene 
Entrez Gene cytogenetic band: 5q22.1 Ensembl cytogenetic band: 5q22.1 HGNC cytogenetic band: 5q22.2WDR36 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P110455:
(about GC identifiers)
Start:
|
110,455,769 bp from pter |
End:
|
110,494,099 bp from pter |
Size:
|
38,331 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_034772.5
| Proteins for WDR36
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36 (See
protein sequence)Recommended Name: WD repeat-containing protein 36 Size: 951 amino acids; 105322 Da
Secondary accessions: A2RUS4 Q8N1Q2REFSEQ proteins: NP_644810.1
ENSEMBL proteins: ENSP00000319771
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0032040 | small-subunit processome |
IEA | -- | About this table
Antibodies for WDR36: Assays for WDR36: | Protein
Domains/ Families for WDR36(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8NI36
ProtoNet protein and cluster: Q8NI36 1 Blocks protein family: IPB000873 AMP-binding signature
UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36Similarity: Contains 9 WD repeats | Gene Function for WDR36
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139281
Applied Biosystems Silencer® siRNAs for WDR36
Sigma-Aldrich siRNA for WDR36  Sigma-Aldrich shRNA for WDR36  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_139281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_139281                                  untagged cDNA clone in CMV expression vector: NM_139281 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_139281
UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36Function: Involved in T cell activation and highly co-regulated with IL21 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | About this table | Pathways & Interactions for WDR36
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/12 Interacting proteins for WDR36 (ENSP000003197713) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for WDR36(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for WDR36
|
Transcripts for WDR36(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_139281
Sigma-Aldrich siRNA for WDR36  Sigma-Aldrich shRNA for WDR36  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_139281 REFSEQ mRNAs for WDR36 gene: NM_139281.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_139281               OriGene GFP tagged cDNA clone in CMV expression vector: NM_139281                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_139281                                  untagged cDNA clone in CMV expression vector: NM_139281  Additional cDNA sequence: AF385437.1 AK055664.1 AK074202.1 AK095312.1 AL832494.1 BC037427.1 BC133025.1 BC136517.1 CR600030.1 CR749211.1 6 DOTS entries: DT.100024414 DT.95266600 DT.441426 DT.120828713 DT.102830676 DT.40122924 24/154 AceView cDNA sequences (see all 154
):AU185710 BM453755 AA770692 AF385437 AK095312 AI452987 AA442593 AK055664 BP365899 BQ420958 N28000 CD514861 BM129741 BQ231864 AA768963 CK819663 AA827623 BF056935 AI695924 W74458 CB243764 AA805260 AA039378 NM_139281
highest scoring ESTs for WDR36:AI655936 AA039378 AA039379 AA043752 AA043753 AA057286 AA057301 AA235034 AA235103 AA235202 Unigene Cluster for WDR36: WD repeat domain 36 Hs.533237 [show with all ESTs]Unigene Representative Sequence: NM_139281
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for WDR36
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for WDR36
1 Ensembl transcript including schematic representation: ENST00000323652
|
Expression for WDR36
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| WDR36 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for WDR36
1 / 2 / 3 8 probe-sets matching WDR36 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTGTCTGTTT
SOURCE GeneReport for Unigene cluster: Hs.533237 UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve |
Orthologs for WDR36
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for WDR36 gene from 5/21 species (see all 21
)
About this table Species with no ortholog for WDR36
ENSEMBL Gene Tree for WDR36 | Paralogs for WDR36(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for WDR36(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for WDR36 (up to first 250kb)
|
Disorders & Mutations for WDR36
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609669 disorders: 609887 UniProtKB/Swiss-Prot: WDR36_HUMAN, Q8NI36
Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G) [MIM:609887]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place2 Novoseek disease relationships for WDR36 gene
About this table
Human Gene Mutation Database: WDR36 Human Genome Epidemiology Navigator: WDR36 (10 documents)
|
Medical News for WDR36(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for WDR36 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/23 PubMed articles for WDR36 gene (see all 23
):- Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (PubMed id 15677485)1, 2, 3, 4 Monemi S....Sarfarazi M. (2005)
- The small-subunit processome is a ribosome assembly intermediate. (PubMed id 15590835)2, 3 Bernstein K.A....Baserga S.J. (2004)
- T lymphocyte activation gene identification by coregulated expression on DNA microarrays. (PubMed id 15177553)3, 4 Mao M.... Linsley P.S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma. (PubMed id 16723468)1, 3 Hauser M.A....Wiggs J.L. (2006)
- Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma. (PubMed id 19347049)1, 3 Fan B.J....Pang C.P. (2009)
- The role of the WDR36 gene on chromosome 5q22.1 in a large family with primary open-angle glaucoma mapped to this region. (PubMed id 16966629)1, 3 Kramer P.L....Wirtz M.K. (2006)
- Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. (PubMed id 19145250)1, 3 Jia L.Y....Wang N.L. (2009)
- Association between primary open-angle glaucoma and WDR36 DNA sequence variants in Japanese. (PubMed id 17960130)1, 3 Miyazawa A....Nishida K. (2007)
- A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant. (PubMed id 16876519)1, 3 Hewitt A.W....Craig J.E. (2006)
|
Search for WDR36
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing WDR36
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing WDR36
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR36(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GeneReviews | http://www.genetests.org/query?gene=WDR36 |
|
| | | About This Section
| --
| Services for WDR36(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for WDR36:

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Incremental update: 13 Oct 2009
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