Free for academic non-profit institutions. Other users need a Commercial license

Aliases for WDR36 Gene

Aliases for WDR36 Gene

  • WD Repeat Domain 36 2 3 5
  • T-Cell Activation WD Repeat-Containing Protein 3 4
  • TA-WDRP 3 4
  • T-Cell Activation WD Repeat Protein 3
  • WD Repeat-Containing Protein 36 3
  • Glaucoma 1, Open Angle, G 2
  • TAWDRP 3
  • UTP21 3
  • GLC1G 3

External Ids for WDR36 Gene

Previous HGNC Symbols for WDR36 Gene

  • GLC1G

Previous GeneCards Identifiers for WDR36 Gene

  • GC05P110505
  • GC05P110455
  • GC05P110427
  • GC05P105606

Summaries for WDR36 Gene

Entrez Gene Summary for WDR36 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]

GeneCards Summary for WDR36 Gene

WDR36 (WD Repeat Domain 36) is a Protein Coding gene. Diseases associated with WDR36 include Glaucoma 1, Open Angle, G and Glaucoma 1, Open Angle, E. Among its related pathways are Ribosome biogenesis in eukaryotes and rRNA processing in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for WDR36 Gene

  • Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.

Gene Wiki entry for WDR36 Gene

Additional gene information for WDR36 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR36 Gene

Genomics for WDR36 Gene

Regulatory Elements for WDR36 Gene

Enhancers for WDR36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H111091 1.2 ENCODE 85.7 +1.1 1139 2.6 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 NFYC WDR36 RPS3AP21 TSLP ENSG00000249318 BCLAF1P1 ENSG00000253613 LOC100131280 NREP-AS1 SLC25A46 TMEM232
GH05H111223 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.5 +139.9 139938 16.7 HDGF PKNOX1 SIN3A ZNF121 GLIS2 ZNF207 FOS ATF7 KLF7 RUNX3 ENSG00000249318 CAMK4 WDR36 ENSG00000253613 LOC100131280 NREP-AS1 RPS3AP21 TSLP GC05M111236
GH05H111529 1.6 FANTOM5 Ensembl ENCODE 11.6 +439.1 439124 2.2 HDGF PKNOX1 ATF1 ARNT CBX5 GATA2 ZNF143 ATF7 NCOA1 ZNF592 STARD4 SNORA13 RPS3AP21 WDR36 GC05M111479 ENSG00000251099
GH05H111753 1.6 Ensembl ENCODE dbSUPER 11.6 +664.7 664710 5.6 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RPS3AP21 SNORA13 WDR36 BCLAF1P1 NREP RN7SKP57 LOC105379122
GH05H111133 0.5 ENCODE 11.8 +42.9 42916 2 ZSCAN5C MNT HNF4A TSLP WDR36 GC05P111128 GC05M111139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around WDR36 on UCSC Golden Path with GeneCards custom track

Promoters for WDR36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000185177 1085 2000 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3

Genomic Locations for WDR36 Gene

Genomic Locations for WDR36 Gene
38,787 bases
Plus strand

Genomic View for WDR36 Gene

Genes around WDR36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WDR36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WDR36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR36 Gene

Proteins for WDR36 Gene

  • Protein details for WDR36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 36
    Protein Accession:
    Secondary Accessions:
    • A2RUS4
    • Q68E02
    • Q8N1Q2

    Protein attributes for WDR36 Gene

    951 amino acids
    Molecular mass:
    105322 Da
    Quaternary structure:
    No Data Available
    • Depletion of WDR36 mRNA in cultured cells causes apoptotic cell death and consistently associates with a reduced 21S rRNA and delay of 18S rRNA maturation.
    • Sequence=BAC04527.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for WDR36 Gene

Post-translational modifications for WDR36 Gene

  • Ubiquitination at posLast=284284, Lys413, Lys446, Lys814, Lys824, and posLast=839839
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WDR36 Gene

Domains & Families for WDR36 Gene

Gene Families for WDR36 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for WDR36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.
  • The WD repeats are grouped into two tandem seven-bladed beta-propeller regions.
genes like me logo Genes that share domains with WDR36: view

Function for WDR36 Gene

Molecular function for WDR36 Gene

UniProtKB/Swiss-Prot Function:
Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.

Phenotypes From GWAS Catalog for WDR36 Gene

Gene Ontology (GO) - Molecular Function for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with WDR36: view
genes like me logo Genes that share phenotypes with WDR36: view

Human Phenotype Ontology for WDR36 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for WDR36 Gene

MGI Knock Outs for WDR36:

Animal Model Products

CRISPR Products

miRNA for WDR36 Gene

miRTarBase miRNAs that target WDR36

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for WDR36 Gene

Localization for WDR36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR36 Gene

Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WDR36 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA,IDA --
GO:0032040 small-subunit processome IBA --
genes like me logo Genes that share ontologies with WDR36: view

Pathways & Interactions for WDR36 Gene

genes like me logo Genes that share pathways with WDR36: view

Gene Ontology (GO) - Biological Process for WDR36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEA --
GO:0006364 rRNA processing TAS,IBA --
GO:0007601 visual perception IEA --
GO:0008150 biological_process ND --
GO:0030516 regulation of axon extension IEA --
genes like me logo Genes that share ontologies with WDR36: view

No data available for SIGNOR curated interactions for WDR36 Gene

Drugs & Compounds for WDR36 Gene

No Compound Related Data Available

Transcripts for WDR36 Gene

Unigene Clusters for WDR36 Gene

WD repeat domain 36:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for WDR36 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2: - - -

Relevant External Links for WDR36 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WDR36 Gene

Protein differential expression in normal tissues from HIPED for WDR36 Gene

This gene is overexpressed in CD8 Tcells (7.2), Testis (7.2), and Fetal ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for WDR36 Gene

Protein tissue co-expression partners for WDR36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WDR36 Gene:


SOURCE GeneReport for Unigene cluster for WDR36 Gene:


mRNA Expression by UniProt/SwissProt for WDR36 Gene:

Tissue specificity: Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve.

Evidence on tissue expression from TISSUES for WDR36 Gene

  • Nervous system(4.6)
  • Eye(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for WDR36 Gene

Germ Layers:
  • ectoderm
  • nervous
Head and neck:
  • eye
  • head
genes like me logo Genes that share expression patterns with WDR36: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for WDR36 Gene

Orthologs for WDR36 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for WDR36 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR36 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia WDR36 33 34
  • 91.54 (n)
(Bos Taurus)
Mammalia WDR36 33 34
  • 90.65 (n)
(Mus musculus)
Mammalia Wdr36 33 16 34
  • 86.85 (n)
(Rattus norvegicus)
Mammalia LOC688637 33
  • 86.41 (n)
(Monodelphis domestica)
Mammalia WDR36 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia WDR36 34
  • 75 (a)
(Gallus gallus)
Aves WDR36 33 34
  • 73.25 (n)
(Anolis carolinensis)
Reptilia WDR36 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr36 33
  • 67.72 (n)
Str.768 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53182 33
(Danio rerio)
Actinopterygii wdr36 33 34
  • 65.43 (n)
wufb33e10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2846 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004557 33
  • 49.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9799 33 34
  • 48.3 (n)
(Caenorhabditis elegans)
Secernentea Y45F10D.7 34
  • 28 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B02827g 33
  • 46.42 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UTP21 33 34
  • 46.33 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER081C 33
  • 45.46 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G04940 33
  • 48.31 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1672.07 33
  • 47.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07011 33
  • 43.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11006 33
Species where no ortholog for WDR36 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR36 Gene

Gene Tree for WDR36 (if available)
Gene Tree for WDR36 (if available)

Paralogs for WDR36 Gene

(1) SIMAP similar genes for WDR36 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WDR36: view

No data available for Paralogs for WDR36 Gene

Variants for WDR36 Gene

Sequence variations from dbSNP and Humsavar for WDR36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs116529882 Pathogenic, Glaucoma 1, open angle, G (GLC1G) [MIM:609887] 111,110,280(+) ACATC(A/G)AGGAA reference, missense
rs118204022 Pathogenic, Glaucoma 1, open angle, G (GLC1G) [MIM:609887] 111,104,342(+) TGACA(A/G)TGCTC reference, missense
rs372059163 Glaucoma 1, open angle, G (GLC1G) [MIM:609887] 111,107,405(+) CAAGC(C/G)AAAAG reference, missense
rs549211166 Glaucoma 1, open angle, G (GLC1G) [MIM:609887] 111,092,578(+) GTTCT(A/G)TGTAA reference, missense
rs771276992 Glaucoma 1, open angle, G (GLC1G) [MIM:609887] 111,105,306(+) ATGGA(A/G)CTCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for WDR36 Gene

Variant ID Type Subtype PubMed ID
nsv599365 CNV loss 21841781
nsv599364 CNV gain 21841781
nsv599362 CNV gain 21841781
nsv519338 CNV gain 19592680
nsv1031124 CNV loss 25217958
nsv1028053 CNV gain 25217958
esv3606263 CNV gain 21293372
esv3606262 CNV loss 21293372
esv3606259 CNV loss 21293372
esv2763483 CNV gain 21179565
dgv5781n100 CNV gain 25217958
dgv5780n100 CNV gain 25217958
dgv5779n100 CNV gain 25217958
dgv1638e212 CNV gain 25503493
dgv1637e212 CNV gain 25503493
dgv10005n54 CNV gain 21841781
dgv10004n54 CNV gain 21841781

Variation tolerance for WDR36 Gene

Residual Variation Intolerance Score: 18.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR36 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR36 Gene

Disorders for WDR36 Gene

MalaCards: The human disease database

(9) MalaCards diseases for WDR36 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glaucoma 1, open angle, g
  • primary open angle glaucoma 1g
glaucoma 1, open angle, e
  • primary open angle glaucoma
open-angle glaucoma
  • glaucoma simplex
preimplantation embryonic lethality
  • preimplantation embryonic lethality 1
primary congenital glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search WDR36 in MalaCards View complete list of genes associated with diseases


  • Glaucoma 1, open angle, G (GLC1G) [MIM:609887]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:15677485, ECO:0000269 PubMed:18172102}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for WDR36

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR36: view

No data available for Genatlas for WDR36 Gene

Publications for WDR36 Gene

  1. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. (PMID: 15677485) Monemi S … Sarfarazi M (Human molecular genetics 2005) 2 3 4 22 60
  2. Multiple gene polymorphisms analysis revealed a different profile of genetic polymorphisms of primary open-angle glaucoma in northern Chinese. (PMID: 19145250) Jia LY … Wang NL (Molecular vision 2009) 3 22 45 60
  3. Different WDR36 mutation pattern in Chinese patients with primary open-angle glaucoma. (PMID: 19347049) Fan BJ … Pang CP (Molecular vision 2009) 3 22 45 60
  4. [Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg]. (PMID: 20198978) Motushchuk AE … Vasil'ev VB (Genetika 2009) 3 22 45 60
  5. Profiling of WDR36 missense variants in German patients with glaucoma. (PMID: 18172102) Pasutto F … Reis A (Investigative ophthalmology & visual science 2008) 3 4 45 60

Products for WDR36 Gene

Sources for WDR36 Gene

Loading form....