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WDR35 Gene

protein-coding   GIFtS: 50
GCID: GC02M020110

WD Repeat Domain 35

  See WDR35-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
WD Repeat Domain 351 2     KIAA13363 5
Intraflagellar Transport Protein 121 Homolog2 3     IFTA12
IFT1212 3     naofen2
CED22 5     WD Repeat-Containing Protein 352
SRTD72 5     NAOFEN5

External Ids:    HGNC: 292501   Entrez Gene: 575392   Ensembl: ENSG000001189657   OMIM: 6136025   UniProtKB: Q9P2L03   

Export aliases for WDR35 gene to outside databases

Previous GC identifers: GC02M020097 GC02M020031 GC02M019867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR35 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients
with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene,
consistent with a possible ciliary function.(provided by RefSeq, Sep 2010)

GeneCards Summary for WDR35 Gene:
WDR35 (WD repeat domain 35) is a protein-coding gene. Diseases associated with WDR35 include short-rib thoracic dysplasia 7 with or without polydactyly, and short rib-polydactyly syndrome, type v. An important paralog of this gene is TULP2.

UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required
for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the WDR35 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   HNF-3beta   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR35 promoter sequence
   Search Chromatin IP Primers for WDR35

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24.3

WDR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR35 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M020110:  view genomic region     (about GC identifiers)

Start:
20,110,021 bp from pter      End:
20,189,892 bp from pter
Size:
79,872 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 (See protein sequence)
Recommended Name: WD repeat-containing protein 35  
Size: 1181 amino acids; 133547 Da
Subunit: Component of the IFT complex A (IFT-A). Interacts with IFT43
Sequence caution: Sequence=BAA92574.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KVI5 Q4ZG01 Q8NE11
Alternative splicing: 2 isoforms:  Q9P2L0-1   Q9P2L0-2   

Explore the universe of human proteins at neXtProt for WDR35: NX_Q9P2L0

Explore proteomics data for WDR35 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys776, Lys815
  • Modification sites at PhosphoSitePlus

  • See WDR35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006658.1  NP_065830.2  

    ENSEMBL proteins: 
     ENSP00000281405   ENSP00000314444   ENSP00000390105   ENSP00000390802   ENSP00000404409  
     ENSP00000399159  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IFT: Intraflagellar transport homologs
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR017233 WD_repeat_p35
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9P2L0

    ProtoNet protein and cluster: Q9P2L0

    UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
    Similarity: Contains 5 WD repeats


    Find genes that share domains with WDR35           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR35_HUMAN, Q9P2L0
    Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required
    for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis
    Induction: By TNF

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with WDR35           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Wdr35):
     cardiovascular system  digestive/alimentary  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  muscle  respiratory system  skeleton 

    Find genes that share phenotypes with WDR35           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for WDR35

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    WDR35_HUMAN, Q9P2L0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).
    Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol2
    nucleus2
    golgi apparatus1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome ISS--
    GO:0005930axoneme ISS--
    GO:0030991intraciliary transport particle A IDA--
    GO:0036064ciliary basal body ISS--

    Find genes that share ontologies with WDR35           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for WDR35
    Interactions:

        Search GeneGlobe Interaction Network for WDR35

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for WDR35 (Q9P2L03 ENSP000003144444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    SMAD4Q134853I2D: score=4 
    GBASO753233I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly IMP--

    Find genes that share ontologies with WDR35           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for WDR35



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for WDR35 gene (2 alternative transcripts): 
    NM_001006657.1  NM_020779.3  

    Unigene Cluster for WDR35:

    WD repeat domain 35
    Hs.205427  [show with all ESTs]
    Unigene Representative Sequence: NM_001006657
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281405(uc002rdh.3) ENST00000345530(uc002rdi.3 uc002rdj.3 uc010ext.3)
    ENST00000445063 ENST00000414212 ENST00000453014(uc002rdk.4) ENST00000494964
    ENST00000416055
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    Additional mRNA sequence: 

    AB037757.2 AK022866.1 AK091205.1 AK122917.1 AK315094.1 AL832903.1 BC033951.1 BC036659.2 

    9 DOTS entries:

    DT.91979241  DT.213590  DT.100750220  DT.75104049  DT.40189556  DT.75162839  DT.102825812  DT.75120533 
    DT.95240461 

    Selected AceView cDNA sequences (see all 99):

    AA428148 AA781940 AK122917 W15406 BE504295 BM142108 AA471008 BF448208 
    AI989626 BE219496 AB037757 AA809884 CA435678 AI612959 BI554083 BE047174 
    CF455231 Z38228 BX642069 CK300850 Z41934 BX950916 BM993938 AI698182 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR35    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                            -                                                               
    SP2:                                                                          -                 -                                                               
    SP3:                                                                          -     -           -                                                               
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                          
    SP2:                                          
    SP3:  -     -                 -               
    SP4:                                          


    ECgene alternative splicing isoforms for WDR35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    WDR35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATATTCC
    WDR35 Expression
    About this image

    WDR35 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    WDR35 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.205427
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for WDR35 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr351 , 5 WD repeat domain 351, 5 86.72(n)1
    92.37(a)1
      12 (3.97 cM)5
    746821  NM_172470.31  NP_766058.31 
     89738925 
    chicken
    (Gallus gallus)
    Aves WDR351 WD repeat domain 35 80.79(n)
    86.04(a)
      421958  XM_419970.4  XP_419970.3 
    lizard
    (Anolis carolinensis)
    Reptilia WDR356
    WD repeat domain 35
    81(a)
    1 ↔ 1
    1(153519464-153561204)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia wdr351 WD repeat domain 35 75.84(n)
    82.9(a)
      100496375  XM_002934481.2  XP_002934527.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr351 WD repeat domain 35 71.63(n)
    79.42(a)
      565515  NM_001145589.1  NP_001139061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Oseg41 Oseg4 54.3(n)
    50.61(a)
      38219  NM_001274349.1  NP_001261278.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ifta-11 ifta-1 48.17(n)
    34.7(a)
      183817  NM_076539.3  NP_508940.3 


    ENSEMBL Gene Tree for WDR35 (if available)
    TreeFam Gene Tree for WDR35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for WDR35 gene
    TULP22  TULP42  TUB2  TULP12  TULP32  
    1 SIMAP similar gene for WDR35 using alignment to 5 protein entries:     WDR35_HUMAN (see all proteins):
    DKFZp762F1313

    Find genes that share paralogs with WDR35           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for WDR35 (see all 1602)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0659554
    Short rib-polydactyly syndrome 5 (SRPS5)4--see VAR_0659552 W R mis40--------
    VAR_0645814
    Cranioectodermal dysplasia 2 (CED2)4--see VAR_0645812 E G mis40--------
    VAR_0645824
    Cranioectodermal dysplasia 2 (CED2)4--see VAR_0645822 A T mis40--------
    rs674219901,2
    C--19936840(+) CCCCT-/ACACACA 2 -- int11Minor allele frequency- AC:0.00NA 2
    rs2017145821,2
    C--20050503(+) TATTC-/AAAAAA 2 -- ds50010--------
    rs1866032711,2
    --20050699(+) CCTTCA/GTTCCT 2 -- ds50010--------
    rs1915649701,2
    --20050803(+) TTCCCC/TCCTTG 2 -- ds50010--------
    rs1422982001,2
    --20050938(+) ACACCA/GTGTTC 2 -- ds50010--------
    rs1132803291,2
    C--20051015(+) TTTTCG/ATATTT 2 -- ut312Minor allele frequency- A:0.07CSA WA 120
    rs1829040511,2
    C--20051027(+) TTCACC/TTAATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR35 (20110021 - 20189892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for WDR35:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273450CNV Insertion20981092
    esv29979CNV Loss17803354
    nsv521619CNV Loss19592680
    dgv4067n71CNV Gain21882294
    nsv873715CNV Gain21882294
    nsv873714CNV Gain21882294
    nsv527453CNV Gain19592680

    Human Gene Mutation Database (HGMD): WDR35
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing WDR35
    DNA2.0 Custom Variant and Variant Library Synthesis for WDR35

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613602   
    OMIM disorders: 613610  614091  
    UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
  • Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and
    ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow
    thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus
    with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely
    spaced, hypoplastic and fused teeth. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Short rib-polydactyly syndrome 5 (SRPS5) [MIM:614091]: A lethal skeletal dysplasia characterized by
    markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including
    heart, intestines, genitalia, kidney, liver, and pancreas. Additional SRPS5 hallmarks are acromesomelic
    hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys. Note=The disease is
    caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly
    syndrome through impaired cilia formation. Primary fibroblasts from SRPS5 patients lacking WDR35 fail to produce
    cilia (PubMed:21473986)

  • 10 diseases for WDR35:    
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    short-rib thoracic dysplasia 7 with or without polydactyly    short rib-polydactyly syndrome, type v    cranioectodermal dysplasia 2    sensenbrenner syndrome
    suppurative lymphadenitis    cranioectodermal dysplasia 1    short-rib thoracic dysplasia 11 with or without polydactyly    short rib-polydactyly syndrome
    ellis-van creveld syndrome    asphyxiating thoracic dystrophy

    4 diseases from the University of Copenhagen DISEASES database for WDR35:
    Sensenbrenner syndrome     Polydactyly     Asphyxiating thoracic dystrophy     Ellis-Van Creveld syndrome

    Find genes that share disorders with WDR35           About GenesLikeMe


    Export disorders for WDR35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for WDR35 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with WDR35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. (PubMed id 21473986)1, 2 Mill P.... Amor D.J. (Am. J. Hum. Genet. 2011)
    3. Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome. (PubMed id 20817137)1, 2 Gilissen C.... Brunner H.G. (Am. J. Hum. Genet. 2010)
    4. Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis. (PubMed id 20193664)1, 2 Feng G.G....Ishikawa N. (Biochem. Biophys. Res. Commun. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Novel WDR35 mutations in patients with cranioectodermal dysplasia (Sensenbrenner syndrome). (PubMed id 22486404)1 Hoffer J.L....Tzschach A. (Clin. Genet. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. WDR35 mutation in siblings with Sensenbrenner syndrome: a ciliopathy with variable phenotype. (PubMed id 22987818)1 Bacino C.A....Bonnen P.E. (Am. J. Med. Genet. A 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57539 HGNC: 29250 AceView: WDR35 Ensembl:ENSG00000118965 euGenes: HUgn57539
    ECgene: WDR35 H-InvDB: WDR35

    (According to HUGE)
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    HUGE: KIAA1336

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for WDR35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for WDR35 gene:
    Search GeneIP for patents involving WDR35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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