WDR35 Gene

Aliases
for WDR35 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC02M020097 GC02M020031 GC02M019867

Summaries
for WDR35 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for WDR35 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11  NT_022184.16  NC_018913.2  

SwitchGear Promoter luciferase reporter plasmid: WDR35 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR35

WDR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M020110:  view genomic region     (about GC identifiers)

Proteins
for WDR35 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for WDR35: NX_Q9P2L0

Explore proteomics data for WDR35 at MOPED

Post-translational modifications: 

WDR35 Human Recombinant Protein Products:

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	antibodies-online peptides for WDR35

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WDR35 Assay Products:

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Domains /
Families
for WDR35 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9P2L0

Find genes that share domains with WDR35           About GenesLikeMe

Function
for WDR35 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

(inferred from 2 alleles) (MGI details for Wdr35)

genOway: Develop your customized and physiologically relevant rodent model for WDR35

miRNA Products:		Block miRNA regulation of human, mouse, rat WDR35 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate WDR35 (see all 17):
		hsa-miR-3673 hsa-miR-624* hsa-miR-221 hsa-miR-374a* hsa-miR-629* hsa-miR-205* hsa-miR-223* hsa-miR-205
		SwitchGear 3'UTR luciferase reporter plasmid: WDR35 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for WDR35
		Predesigned siRNA for gene silencing in human, mouse, rat WDR35

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for WDR35

Clone Products:		OriGene clones in human, mouse for WDR35 (see all 13) OriGene ORF clones in mouse, rat for WDR35 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): WDR35 (NM_020779)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR35

Localization
for WDR35 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	4
cytosol	2
nucleus	2
golgi apparatus	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for WDR35 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for WDR35 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for WDR35 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for WDR35 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WDR35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAATATTCC

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for WDR35 OriGene qSTAR qPCR primer pairs in human, mouse for WDR35
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat WDR35
		QuantiTect SYBR Green Assays in human, mouse, rat WDR35
		QuantiFast Probe-based Assays in human, mouse, rat WDR35

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR35

Orthologs
for WDR35 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for WDR35 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for WDR35 gene

TULP2²  TULP4²  TUB²  TULP1²  TULP3²  

1 SIMAP similar gene for WDR35 using alignment to 5 protein entries:     WDR35_HUMAN (see all proteins):

DKFZp762F1313

Find genes that share paralogs with WDR35           About GenesLikeMe

Genomic Variants
for WDR35 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for WDR35 (see all 1602)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
VAR_0659554		Short rib-polydactyly syndrome 5 (SRPS5)4	--	see VAR_065955	2	W R	mis4		0	--	--	--	--
VAR_0645814		Cranioectodermal dysplasia 2 (CED2)4	--	see VAR_064581	2	E G	mis4		0	--	--	--	--
VAR_0645824		Cranioectodermal dysplasia 2 (CED2)4	--	see VAR_064582	2	A T	mis4		0	--	--	--	--
rs674219901,2	C	--	19936840(+)	CCCCT-/ACACACA	2	--	int1		1		NA	2
rs2017145821,2	C	--	20050503(+)	TATTC-/AAAAAA	2	--	ds5001		0	--	--	--	--
rs1866032711,2		--	20050699(+)	CCTTCA/GTTCCT	2	--	ds5001		0	--	--	--	--
rs1915649701,2		--	20050803(+)	TTCCCC/TCCTTG	2	--	ds5001		0	--	--	--	--
rs1422982001,2		--	20050938(+)	ACACCA/GTGTTC	2	--	ds5001		0	--	--	--	--
rs1132803291,2	C	--	20051015(+)	TTTTCG/ATATTT	2	--	ut31		2		CSA WA	120
rs1829040511,2	C	--	20051027(+)	TTCACC/TTAATA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for WDR35 (20110021 - 20189892 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for WDR35:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv273450	CNV	Insertion	20981092
esv29979	CNV	Loss	17803354
nsv521619	CNV	Loss	19592680
dgv4067n71	CNV	Gain	21882294
nsv873715	CNV	Gain	21882294
nsv873714	CNV	Gain	21882294
nsv527453	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): WDR35

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing WDR35

DNA2.0 Custom Variant and Variant Library Synthesis for WDR35

Disorders / Diseases
for WDR35 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for WDR35 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2000)
2. Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. (PubMed id 21473986)^{1, 2} Mill P.... Amor D.J. (Am. J. Hum. Genet. 2011)
3. Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome. (PubMed id 20817137)^{1, 2} Gilissen C.... Brunner H.G. (Am. J. Hum. Genet. 2010)
4. Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis. (PubMed id 20193664)^{1, 2} Feng G.G....Ishikawa N. (Biochem. Biophys. Res. Commun. 2010)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (DNA Res. 2002)
8. Novel WDR35 mutations in patients with cranioectodermal dysplasia (Sensenbrenner syndrome). (PubMed id 22486404)¹ Hoffer J.L....Tzschach A. (Clin. Genet. 2013)
9. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
10. WDR35 mutation in siblings with Sensenbrenner syndrome: a ciliopathy with variable phenotype. (PubMed id 22987818)¹ Bacino C.A....Bonnen P.E. (Am. J. Med. Genet. A 2012)

External Searches for WDR35 gene

Genome Databases showing WDR35 gene

Other Databases showing WDR35 gene

Specialized Databases showing WDR35 gene

Products
for WDR35 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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