Aliases for WDR35 Gene
External Ids for WDR35 Gene
Previous GeneCards Identifiers for WDR35 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]
GeneCards Summary for WDR35 Gene
WDR35 (WD Repeat Domain 35) is a Protein Coding gene. Diseases associated with WDR35 include Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly and Cranioectodermal Dysplasia 2. Among its related pathways are Signaling by Hedgehog and Signaling by GPCR. GO annotations related to this gene include binding. An important paralog of this gene is TULP4.
UniProtKB/Swiss-Prot for WDR35 Gene
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.