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Aliases & Descriptions for WDR35
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA1336 1 , 2 , 3 MGC33196 1 , 2
Descriptions WD repeat domain 35 2
Search outside databases for aliases for WDR35 genePrevious GC identifer: GC02M020097
Summaries for WDR35 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for WDR35 : This gene encodes a member of the WD repeat protein family. WD repeats are minimally conservedregions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), whichmay facilitate formation of heterotrimeric or multiprotein complexes. Members of this family areinvolved in a variety of cellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variantsencoding distinct isoforms have been found for this gene, but the biological validity of somevariants has not been determined. [provided by RefSeq]
Genomic Location for WDR35
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the WDR35 gene Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p24.3 WDR35 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M020031:
(about GC identifiers )
Start:
19,973,505 bp from pter
End:
20,053,373 bp from pter
Size:
79,869 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.10 NT_015926.14 Proteins for WDR35
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 (See
protein sequence )Recommended Name: WD repeat-containing protein 35 Size : 1181 amino acids; 133547 Da
Secondary accessions : Q8NE11Alternative splicing : 2 isoforms : Q9P2L0-1 Q9P2L0-2
REFSEQ proteins (2 alternative transcripts):
NP_001006658.1 NP_065830.2 ENSEMBL proteins: ENSP00000314444 ENSP00000281405 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for WDR35: Assays for WDR35:
Protein
Domains/ Families for WDR35(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9P2L0 ProtoNet protein and cluster: Q9P2L0
UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 Similarity : Contains 5 WD repeats
Gene Function for WDR35
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020779 Applied Biosystems Silencer ® siRNAs for WDR35 Sigma-Aldrich siRNA for WDR35 Sigma-Aldrich shRNA for WDR35 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006657                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006657                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001006657  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001006657 Pathways & Interactions for WDR35
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Drugs & Compounds for WDR35 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for WDR35
Transcripts for WDR35(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020779 Sigma-Aldrich siRNA for WDR35 Sigma-Aldrich shRNA for WDR35 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001006657 NM_020779
REFSEQ mRNAs for WDR35 gene (2 alternative transcripts): NM_001006657.1 NM_020779.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001006657 NM_020779
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006657                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001006657                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001006657  
Additional cDNA sequence: AB037757.2 AK022866.1 AK091205.1 AK122917.1 AK315094.1 AL832903.1 BC033951.1 BC036659.2
9 DOTS entries : DT.91979241 DT.213590 DT.100750220 DT.75104049 DT.40189556 DT.75162839 DT.102825812 DT.95240461 DT.75120533
24/99 AceView cDNA sequences (see all 99
):AI692656 BX950916 AA428148 BE504295 CA435678 CK300850 BF448208 BX642069 AA471008 Z38228 BE047174 AA912732 AA897428 AA809884 AI698182 BE219496 BI554083 CF455231 AB037757 AI311462 BM142108 BM993938 AA781940 AI989626
highest scoring ESTs for WDR35 :AB037757 AI638232 AI698182 AK122917 BC036659 BI460483 BX642068 AA471008 AA774445 AA774457
Unigene Cluster for WDR35: WD repeat domain 35 Hs.205427 [show with all ESTs ] Unigene Representative Sequence: NM_001006657 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR35 ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ SP1 :                               -                       SP2 :                         -       -                       SP3 :                         -   -     -                       SP4 :                                                    
ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b SP1 :               SP2 :               SP3 : -   -       -       SP4 :              
About this scheme ECgene alternative splicing isoforms for WDR35 2 Ensembl transcripts including schematic representations : ENST00000345530
ENST00000281405
Expression for WDR35
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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WDR35 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for WDR35 1 / 2 / 3
6 probe-sets matching WDR35 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAAATATTCCSOURCE GeneReport for Unigene cluster: Hs.205427
Orthologs for WDR35
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for WDR35 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for WDR35 ENSEMBL Gene Tree for WDR35 Paralogs for WDR35 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for WDR35 gene TULP4 2
SNPs/Variants for WDR35 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for WDR35 (up to first 250kb)
Disorders & Mutations for WDR35
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for WDR35 (Possibly Related Articles in
Doctor's Guide )
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Publications for WDR35 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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5 PubMed articles for WDR35 gene :
Search for WDR35
(in PubMed ,
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Genome Databases showing WDR35
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing WDR35
(According to HUGE )
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Specialized Databases showing WDR35 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for WDR35 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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