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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR35 Gene

protein-coding   GIFtS: 50
GCID: GC02M020110

WD Repeat Domain 35
  See related diseases
at
MalaCards
 

Aliases
for WDR35 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
WD Repeat Domain 351 2     KIAA13363 5
Intraflagellar Transport Protein 121 Homolog2 3     naofen2
IFT1212 3     WD Repeat-Containing Protein 352
CED22 5     NAOFEN5

External Ids:    HGNC: 292501   Entrez Gene: 575392   Ensembl: ENSG000001189657   OMIM: 6136025   UniProtKB: Q9P2L03   

Export aliases for WDR35 gene to outside databases

Previous GC identifers: GC02M020097 GC02M020031 GC02M019867


Summaries
for WDR35 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for WDR35 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients
with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene,
consistent with a possible ciliary function.(provided by RefSeq, Sep 2010)

GeneCards Summary for WDR35 Gene: 
WDR35 (WD repeat domain 35) is a protein-coding gene. Diseases associated with WDR35 include sensenbrenner syndrome, and short rib-polydactyly syndrome, type v. An important paralog of this gene is TULP2.

UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required
for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis




Genomic Views
for WDR35 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_015926.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR35 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   HNF-3beta   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR35 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24.3

WDR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR35 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M020110:  view genomic region     (about GC identifiers)

Start:
 20,110,021 bp from pter      End:
 20,189,892 bp from pter
Size:
 79,872 bases      Orientation:
 minus strand

Proteins
for WDR35 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 (See protein sequence)
Recommended Name: WD repeat-containing protein 35  
Size: 1181 amino acids; 133547 Da
Subunit: Component of the IFT complex A (IFT-A). Interacts with IFT43
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).
Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By
similarity)
Sequence caution: Sequence=BAA92574.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KVI5 Q4ZG01 Q8NE11
Alternative splicing: 2 isoforms:  Q9P2L0-1   Q9P2L0-2   

Explore the universe of human proteins at neXtProt for WDR35: NX_Q9P2L0

Explore proteomics data for WDR35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2L0

    • WDR35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR35 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001006658.1  NP_065830.2  

    ENSEMBL proteins: 
     ENSP00000281405   ENSP00000314444   ENSP00000390105   ENSP00000390802   ENSP00000404409  
     ENSP00000399159  

    Human Recombinant Protein Products for WDR35: 
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    Novus Biologicals WDR35 Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for WDR35 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome ISS--
    GO:0005932microtubule basal body ISS--
    GO:0030991intraflagellar transport particle A IDA--
    GO:0035085cilium axoneme ISS--

    WDR35 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for WDR35 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom
     IPR017233 WD_repeat_p35

    Graphical View of Domain Structure for InterPro Entry Q9P2L0

    ProtoNet protein and cluster: Q9P2L0

    UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
    Similarity: Contains 5 WD repeats


    WDR35 for domains           About GeneDecksing


    Function
    for WDR35 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR35_HUMAN, Q9P2L0
    Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required
    for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis
    Induction: By TNF

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    WDR35 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wdr35):
     cardiovascular system  digestive/alimentary  embryogenesis  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  muscle  respiratory system  skeleton 

    WDR35 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR35 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for WDR35 
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    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR35 (see all 17):
    hsa-miR-3673 hsa-miR-624* hsa-miR-221 hsa-miR-374a* hsa-miR-629* hsa-miR-205* hsa-miR-223* hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmid: WDR35 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Pathways & Interactions
    for WDR35 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR35

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for WDR35 (Q9P2L03 ENSP000003144444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BCL6P411823, ENSP000002320144I2D: score=2 STRING: ENSP00000232014
    SMAD4Q134853I2D: score=4 
    GBASO753233I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    IQCB1ENSP000003115054STRING: ENSP00000311505
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042384cilium assembly IMP--

    WDR35 for ontologies           About GeneDecksing



    Drugs & Compounds
    for WDR35 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR35

    Search CenterWatch for drugs/clinical trials and news about WDR35

    Transcripts
    for WDR35 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for WDR35 gene (2 alternative transcripts): 
    NM_001006657.1  NM_020779.3  

    Unigene Cluster for WDR35:

    WD repeat domain 35
    Hs.205427  [show with all ESTs]
    Unigene Representative Sequence: NM_001006657
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281405(uc002rdh.3) ENST00000345530(uc002rdi.3 uc002rdj.3 uc010ext.3)
    ENST00000445063 ENST00000414212 ENST00000453014(uc002rdk.4) ENST00000494964
    ENST00000416055
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate WDR35 (see all 17):
    hsa-miR-3673 hsa-miR-624* hsa-miR-221 hsa-miR-374a* hsa-miR-629* hsa-miR-205* hsa-miR-223* hsa-miR-205
    SwitchGear 3'UTR luciferase reporter plasmid: WDR35 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB037757.2 AK022866.1 AK091205.1 AK122917.1 AK315094.1 AL832903.1 BC033951.1 BC036659.2 

    9 DOTS entries:

    DT.91979241  DT.213590  DT.100750220  DT.75104049  DT.40189556  DT.75162839  DT.102825812  DT.75120533 
    DT.95240461 

    24/99 AceView cDNA sequences (see all 99):

    BX950916 BE047174 BX642069 BI554083 Z38228 CK300850 AI698182 BE504295 
    BM142108 AA912732 AI692656 AA428148 BE219496 W15406 Z41934 AA471008 
    AI989626 AK122917 AI612959 BM993938 BF448208 AI311462 AA781940 AB037757 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR35    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                            -                                                               
    SP2:                                                                          -                 -                                                               
    SP3:                                                                          -     -           -                                                               
    SP4:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:                                          
    SP2:                                          
    SP3:  -     -                 -               
    SP4:                                          


    ECgene alternative splicing isoforms for WDR35

    Expression
    for WDR35 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATATTCC
    WDR35 Expression
    About this image


    See WDR35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR35

    SOURCE GeneReport for Unigene cluster: Hs.205427
        SABiosciences Custom PCR Arrays for WDR35
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    Orthologs
    for WDR35 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for WDR35 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Wdr351 , 5 WD repeat domain 351, 5 86.72(n)1
    92.37(a)1    		   12 (3.97 cM)5
    746821  NM_172470.31  NP_766058.31 
     89738925 
    chicken
    (Gallus gallus)    		 Aves WDR351 WD repeat domain 35 80.79(n)
    86.04(a)    		   421958  XM_419970.3  XP_419970.3 
    lizard
    (Anolis carolinensis)    		 Reptilia WDR356
    		 WD repeat domain 35
    		 81(a)
    		 1 ↔ 1
    		 1(153519464-153561204)
    zebrafish
    (Danio rerio)    		 Actinopterygii wdr351 WD repeat domain 35 71.63(n)
    79.42(a)    		   565515  NM_001145589.1  NP_001139061.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Oseg41 CG2069-PA 54.3(n)
    50.61(a)    		   38219  NM_139396.3  NP_647653.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ifta-11 Protein IFTA-1 47.38(n)
    33.93(a)    		   183817  NM_076539.3  NP_508940.3 


    ENSEMBL Gene Tree for WDR35 (if available)
    TreeFam Gene Tree for WDR35 (if available)

    Paralogs
    for WDR35 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR35 gene
    TULP22  TULP42  TUB2  TULP12  TULP32  
    1 SIMAP similar gene for WDR35 using alignment to 5 protein entries:     WDR35_HUMAN (see all proteins):
    DKFZp762F1313

    WDR35 for paralogs           About GeneDecksing



    Genomic Variants
    for WDR35 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1602 SNPs in WDR35 are shown (see all 1602)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    VAR_0659554
    		Short rib-polydactyly syndrome 5 (SRPS5)4--see VAR_0659552 W R mis40--------
    VAR_0645814
    		Cranioectodermal dysplasia 2 (CED2)4--see VAR_0645812 E G mis40--------
    VAR_0645824
    		Cranioectodermal dysplasia 2 (CED2)4--see VAR_0645822 A T mis40--------
    rs674219901,2
    		C--19936840(+) CCCCT-/ACACACA 2 -- int11Minor allele frequency- AC:0.00NA 2
    rs2017145821,2
    		C--20050503(+) TATTC-/AAAAAA 2 -- ds50010--------
    rs1866032711,2
    		--20050699(+) CCTTCA/GTTCCT 2 -- ds50010--------
    rs1915649701,2
    		--20050803(+) TTCCCC/TCCTTG 2 -- ds50010--------
    rs1422982001,2
    		--20050938(+) ACACCA/GTGTTC 2 -- ds50010--------
    rs1132803291,2
    		C--20051015(+) TTTTCG/ATATTT 2 -- ut312Minor allele frequency- A:0.07CSA WA 120
    rs1829040511,2
    		C--20051027(+) TTCACC/TTAATA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for WDR35 (20110021 - 20189892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for WDR35:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273450CNV Insertion20981092
    esv29979CNV Loss17803354
    nsv521619CNV Loss19592680
    dgv4067n71CNV Gain21882294
    nsv873715CNV Gain21882294
    nsv873714CNV Gain21882294
    nsv527453CNV Gain19592680


    Human Gene Mutation Database (HGMD): WDR35
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for WDR35 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 613602   
    OMIM disorders: 613610  
    UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
  • Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and
    ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow
    thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus
    with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely
    spaced, hypoplastic and fused teeth. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Short rib-polydactyly syndrome 5 (SRPS5) [MIM:614091]: A lethal skeletal dysplasia characterized by
    markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including
    heart, intestines, genitalia, kidney, liver, and pancreas. Additional SRPS5 hallmarks are acromesomelic
    hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys. Note=The disease is
    caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly
    syndrome through impaired cilia formation. Primary fibroblasts from SRPS5 patients lacking WDR35 fail to produce
    cilia (PubMed:21473986)

    • 12 diseases for WDR35:    About MalaCards
    sensenbrenner syndrome    short rib-polydactyly syndrome, type v    cranioectodermal dysplasia 2    ellis-van creveld syndrome
    asphyxiating thoracic dystrophy    cystic kidney    dysostosis    skeletal dysplasias
    brachydactyly    craniosynostosis    polydactyly    short stature

    4 diseases from the University of Copenhagen DISEASES database for WDR35:
    Sensenbrenner syndrome     Polydactyly     Asphyxiating thoracic dystrophy     Ellis-Van Creveld syndrome

    WDR35 for disorders           About GeneDecksing


    Export disorders for WDR35 gene to outside databases

    Publications
    for WDR35 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR35 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with WDR35)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Human and mouse mutations in WDR35 cause short-rib po lydactyly syndromes due to abnormal ciliogenesis. (PubMed id 21473986)1, 2 Mill P....Amor D.J. (2011)
    3. Exome sequencing identifies WDR35 variants involved i n Sensenbrenner syndrome. (PubMed id 20817137)1, 2 Gilissen C....Brunner H.G. (2010)
    4. Naofen, a novel WD40-repeat protein, mediates spontan eous and tumor necrosis factor-induced apoptosis. (PubMed id 20193664)1, 2 Feng G.G....Ishikawa N. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Novel WDR35 mutations in patients with cranioectoderma l dysplasia (Sensenbrenner syndrome). (PubMed id 22486404)1 Hoffer J.L....Tzschach A. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. WDR35 mutation in siblings with Sensenbrenner syndrome : a ciliopathy with variable phenotype. (PubMed id 22987818)1 Bacino C.A....Bonnen P.E. (2012)

    External Searches for WDR35 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing WDR35 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57539 HGNC: 29250 AceView: WDR35 Ensembl:ENSG00000118965 euGenes: HUgn57539
    ECgene: WDR35 H-InvDB: WDR35

    Other Databases showing WDR35 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1336

    Specialized Databases showing WDR35 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR35 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for WDR35 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for WDR35 gene:
    Search GeneIP for patents involving WDR35

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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