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WDR35 Gene

protein-coding   GIFtS: 41

GC02M020031
WD repeat domain 35
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for WDR35

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
KIAA1336 1, 2, 3
MGC33196 1, 2
Descriptions
WD repeat domain 35 2
External Ids
HGNC: 292501
Entrez Gene: 575392
UniProtKB: Q9P2L03
Ensembl: ENSG000001189657
Search outside databases for aliases for WDR35 gene

Previous GC identifer: GC02M020097

Summaries
for WDR35

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for WDR35:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved
regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which
may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are
involved in a variety of cellular processes, including cell cycle progression, signal
transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants
encoding distinct isoforms have been found for this gene, but the biological validity of some
variants has not been determined. [provided by RefSeq]

Genomic Location
for WDR35

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the WDR35 gene  

Entrez Gene cytogenetic band: 2p24.1   Ensembl cytogenetic band:  2p24.1   HGNC cytogenetic band: 2p24.3

WDR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M020031:     (about GC identifiers)

Start:
 19,973,505 bp from pter
End:
 20,053,373 bp from pter
Size:
 79,869 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000002.10  NT_015926.14  

Proteins
for WDR35

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 (See protein sequence)
Recommended Name: WD repeat-containing protein 35  
Size: 1181 amino acids; 133547 Da
Secondary accessions: Q8NE11
Alternative splicing: 2 isoforms:  Q9P2L0-1   Q9P2L0-2   

REFSEQ proteins (2 alternative transcripts): 
NP_001006658.1  NP_065830.2  


ENSEMBL proteins: 
ENSP00000314444 ENSP00000281405 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for WDR35: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for WDR35

Assays for WDR35: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for WDR35

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5/7 InterPro domains/families (see all 7 ):
 IPR019782 WD40_repeat_2
 IPR019775 WD40_repeat_CS
 IPR019781 WD40_repeat_sg
 IPR017233 WD_repeat_p35
 IPR001680 WD40_repeat


   GeneDecks  WDR35 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9P2L0

ProtoNet protein and cluster: Q9P2L0

UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0
Similarity: Contains 5 WD repeats

Gene Function
for WDR35

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR35)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020779

              Applied Biosystems Silencer® siRNAs for WDR35

              Sigma-Aldrich siRNA for WDR35  
                     Sigma-Aldrich shRNA for WDR35  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006657
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006657
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001006657 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001006657

Pathways & Interactions
for WDR35

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for WDR35

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR35

Transcripts
for WDR35

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (WDR35)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020779

              Sigma-Aldrich siRNA for WDR35  
                     Sigma-Aldrich shRNA for WDR35  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001006657  NM_020779  

REFSEQ mRNAs for WDR35 gene (2 alternative transcripts): 

NM_001006657.1   NM_020779.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001006657  NM_020779  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001006657
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001006657
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001006657 

Additional cDNA sequence: 

AB037757.2 AK022866.1 AK091205.1 AK122917.1 AK315094.1 AL832903.1 BC033951.1 BC036659.2 

9 DOTS entries:

DT.91979241  DT.213590  DT.100750220  DT.75104049  DT.40189556  DT.75162839  DT.102825812  DT.95240461 
DT.75120533 

24/99 AceView cDNA sequences (see all 99 ):

AI692656 BX950916 AA428148 BE504295 CA435678 CK300850 BF448208 BX642069 
AA471008 Z38228 BE047174 AA912732 AA897428 AA809884 AI698182 BE219496 
BI554083 CF455231 AB037757 AI311462 BM142108 BM993938 AA781940 AI989626 

highest scoring ESTs for WDR35:

AB037757 AI638232 AI698182 AK122917 BC036659 BI460483 BX642068 AA471008 AA774445 AA774457 

Unigene Cluster for WDR35:

WD repeat domain 35
Hs.205427  [show with all ESTs]
Unigene Representative Sequence: NM_001006657


GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR35

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1:                                                                                            -                                                               
SP2:                                                                          -                 -                                                               
SP3:                                                                          -     -           -                                                               
SP4:                                                                                                                                                            

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1:                                          
SP2:                                          
SP3:  -     -                 -               
SP4:                                          

About this scheme

ECgene alternative splicing isoforms for WDR35

2 Ensembl transcripts including schematic representations:
ENST00000345530  ENST00000281405  

Expression
for WDR35

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR35 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for WDR35

1 / 2 / 3

6 probe-sets matching WDR35 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

82741_at2, 3 U95-E 1 1.00 1.00 0.88 1.06 AI638232 0.80 1.00 0.91 1

57507_at2, 3 U95-B 1 1.00 1.00 0.83 0.95 AI698182 0.80 1.00 0.91 1

226889_at2, 3 U133-B 1 1.00 1.00 -- -- AU151732 0.40 1.00 0.76 1

226890_at2, 3 U133-B 1 1.00 1.00 -- -- AW088668 0.60 1.00 0.82 1

226889_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226890_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAAATATTCC

SOURCE GeneReport for Unigene cluster: Hs.205427

Orthologs
for WDR35

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for WDR35 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 WDR351   -- WD repeat domain 35 91.43(n)
94.23(a)		 475677  XM_532884.2  XP_532884.2 
chimpanzee
(Pan troglodytes)		 WDR351   -- WD repeat domain 35 99.49(n)
99.49(a)		 459049  XM_515315.2  XP_515315.2 
mouse
(Mus musculus)		 Wdr351, 5 125
 WD repeat domain 351, 5 86.69(n)1
92.29(a)1		 746821  NM_172470.21  NP_766058.21 
 AK0154905  AK0298965  (see all 12)
chicken
(Gallus gallus)		 WDR351   -- WD repeat domain 35 80.79(n)
86.04(a)		 421958  XM_419970.2  XP_419970.2 
zebrafish
(Danio rerio)		 im:71599451   -- im:7159945 71.82(n)
79.83(a)		 565515  XM_688795.2  XP_693887.2 
About this table        Species with no ortholog for WDR35

ENSEMBL Gene Tree for WDR35

Paralogs
for WDR35

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for WDR35 gene
TULP42  

SNPs/Variants
for WDR35

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/327 NCBI SNPs in WDR35 are shown (see all 327 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 111)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs10607421,2
A,C,F,H20052496(+) CACACT/CGCAGC 2 R/Q mis1 ese310Minor allele frequency- C:0.16EA EU WA NA 2372
rs7219331,2
A,C,F,H20054164(-) TTTGAA/GGCTTT 2 -- ng319Minor allele frequency- T:0.07NS EU EA WA 620
rs9576141,2
A,C,F,H19976277(+) GCCATC/TGCCTC 2 -- ut3113Minor allele frequency- T:0.27MN EU EA WA NA 1382
rs10562331,2
A,C,F,H19976569(-) GTTTTC/ATCTCA 2 -- ut318Minor allele frequency- A:0.27MN NA EU EA WA 734
rs11917781,2
C,F,H,O19994560(+) TCTGTT/CCATGG 2 G/E mis110Minor allele frequency- C:0.22MN EU EA WA NA 1076
rs37316611,2
C,F,H19974337(+) AATTCG/ATTGGT 2 -- ut31 ese312Minor allele frequency- A:0.14EA NA EU WA 2416
rs22936691,2
C,F,H19996702(+) AAATGC/G/TAGTCA 4 A/T A/P mis1 ese35EU EA WA NA 482
rs67489241,2
C,F,H19976702(+) TTTTCA/GTACAA 2 -- ut318Minor allele frequency- G:0.10EU EA WA 838
rs101828661,2
F,H19975311(+) TGTGAC/TAGAAT 2 -- ut314Minor allele frequency- T:0.06EU EA WA 416
rs17334621,2
C,H20009769(+) AACCAA/CCATTA 2 V/G mis15Minor allele frequency- C:0.00MN EU EA WA 600
About this table

HapMap Linkage Disequilibrium images for WDR35 (up to first 250kb)

Disorders & Mutations
for WDR35

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for WDR35

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for WDR35

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for WDR35 gene:

Search for WDR35

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing WDR35

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 57539 HGNC: 29250 AceView: WDR35 Ensembl:ENSG00000118965 euGenes: HUgn57539
ECgene: WDR35 H-InvDB: WDR35

Other Databases showing WDR35

(According to HUGE)
About This Section
HUGE: KIAA1336

Specialized Databases showing WDR35

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for WDR35

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for WDR35

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for WDR35:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for WDR35-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for WDR35 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for WDR35 Browse small molecules at Sigma-Aldrich
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