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WDR35 Gene

protein-coding GIFtS: 50
GCID: GC02M020110

WD Repeat Domain 35

See WDR35-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
WD Repeat Domain 35¹ ²		KIAA1336³ ⁵
Intraflagellar Transport Protein 121 Homolog² ³		IFTA1²
IFT121² ³		naofen²
CED2² ⁵		WD Repeat-Containing Protein 35²
SRTD7² ⁵		NAOFEN⁵

External Ids:	HGNC: 29250¹	Entrez Gene: 57539²	Ensembl: ENSG00000118965⁷	OMIM: 613602⁵	UniProtKB: Q9P2L0³

Export aliases for WDR35 gene to outside databases

Previous GC identifers: GC02M020097 GC02M020031 GC02M019867

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for WDR35 Gene:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of

approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation

of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular

processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple

alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients

with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene,

consistent with a possible ciliary function.(provided by RefSeq, Sep 2010)

GeneCards Summary for WDR35 Gene:

WDR35 (WD repeat domain 35) is a protein-coding gene. Diseases associated with WDR35 include short-rib thoracic dysplasia 7 with or without polydactyly, and cranioectodermal dysplasia 2. An important paralog of this gene is TULP2.

UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0

Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required

for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000002.11 NT_022184.16 NC_018913.2

Regulatory elements:

Regulatory transcription factor binding sites in the WDR35 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 HNF-3beta POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: WDR35 promoter sequence

Search Chromatin IP Primers for WDR35

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat WDR35

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.1 Ensembl cytogenetic band: 2p24.1 HGNC cytogenetic band: 2p24.3

WDR35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR35 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M020110: view genomic region (about GC identifiers)

Start:	20,110,021 bp from pter	End:	20,189,892 bp from pter
Size:	79,872 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0 (See protein sequence)

Recommended Name: WD repeat-containing protein 35

Size: 1181 amino acids; 133547 Da

Subunit: Component of the IFT complex A (IFT-A). Interacts with IFT43

Sequence caution: Sequence=BAA92574.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Secondary accessions: B3KVI5 Q4ZG01 Q8NE11

Alternative splicing: 2 isoforms: Q9P2L0-1 Q9P2L0-2

Explore the universe of human proteins at neXtProt for WDR35: NX_Q9P2L0

Explore proteomics data for WDR35 at MOPED

Post-translational modifications:

Ubiquitination² at Lys776, Lys815

Modification sites at PhosphoSitePlus

See WDR35 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001006658.1 NP_065830.2

ENSEMBL proteins:

ENSP00000281405 ENSP00000314444 ENSP00000390105 ENSP00000390802 ENSP00000404409

ENSP00000399159

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

IFT: Intraflagellar transport homologs

WDR: WD repeat domain containing

4 InterPro protein domains:

IPR017233 WD_repeat_p35

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q9P2L0

ProtoNet protein and cluster: Q9P2L0

UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0

Similarity: Contains 5 WD repeats

Find genes that share domains with WDR35 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: WDR35_HUMAN, Q9P2L0

Function: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required

for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis

Induction: By TNF

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	--	--

Find genes that share ontologies with WDR35 About GenesLikeMe

Phenotypes:
9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Wdr35):

cardiovascular system	digestive/alimentary	embryogenesis	homeostasis/metabolism	limbs/digits/tail
mortality/aging	muscle	respiratory system	skeleton

Find genes that share phenotypes with WDR35 About GenesLikeMe

Animal Models:

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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

WDR35_HUMAN, Q9P2L0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity).

Cytoplasm, cytoskeleton, cilium axoneme (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By

similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	4
cytosol	2
nucleus	2
golgi apparatus	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	ISS	--
GO:0005930	axoneme	ISS	--
GO:0030991	intraciliary transport particle A	IDA	--
GO:0036064	ciliary basal body	ISS	--

Find genes that share ontologies with WDR35 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for WDR35
Interactions:

Search GeneGlobe Interaction Network for WDR35

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

4 Interacting proteins for WDR35 (Q9P2L0³ ENSP00000314444⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCL6	P41182³, ENSP00000232014⁴	I2D: score=2 STRING: ENSP00000232014
SMAD4	Q13485³	I2D: score=4
GBAS	O75323³	I2D: score=1
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0042384	cilium assembly	IMP	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for WDR35

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for WDR35 gene (2 alternative transcripts):

NM_001006657.1 NM_020779.3

Unigene Cluster for WDR35:

WD repeat domain 35

Hs.205427 [show with all ESTs]

Unigene Representative Sequence: NM_001006657

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000281405(uc002rdh.3) ENST00000345530(uc002rdi.3 uc002rdj.3 uc010ext.3)

ENST00000445063 ENST00000414212 ENST00000453014(uc002rdk.4) ENST00000494964

ENST00000416055

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Additional mRNA sequence:

AB037757.2 AK022866.1 AK091205.1 AK122917.1 AK315094.1 AL832903.1 BC033951.1 BC036659.2

9 DOTS entries:

DT.91979241 DT.213590 DT.100750220 DT.75104049 DT.40189556 DT.75162839 DT.102825812 DT.75120533

DT.95240461

Selected AceView cDNA sequences (see all 99):

AA428148 AA781940 AK122917 W15406 BE504295 BM142108 AA471008 BF448208

AI989626 BE219496 AB037757 AA809884 CA435678 AI612959 BI554083 BE047174

CF455231 Z38228 BX642069 CK300850 Z41934 BX950916 BM993938 AI698182

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for WDR35 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^
SP1:																															-
SP2:																									-						-
SP3:																									-		-				-
SP4:

ExUns:	23	^	24	^	25	^	26	^	27	^	28a	·	28b
SP1:
SP2:
SP3:	-		-						-
SP4:

ECgene alternative splicing isoforms for WDR35

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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WDR35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAATATTCC

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WDR35 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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WDR35 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.205427

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for WDR35 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Wdr35^{1 , 5}	WD repeat domain 35^{1, 5}	86.72(n)¹ 92.37(a)¹		12 (3.97 cM)⁵ 74682¹ NM_172470.3¹ NP_766058.3¹ 8973892⁵
chicken (Gallus gallus)	Aves	WDR35¹	WD repeat domain 35	80.79(n) 86.04(a)		421958 XM_419970.4 XP_419970.3
lizard (Anolis carolinensis)	Reptilia	WDR35⁶	WD repeat domain 35	81(a)	1 ↔ 1	1(153519464-153561204)
tropical clawed frog (Xenopus tropicalis)	Amphibia	wdr35¹	WD repeat domain 35	75.84(n) 82.9(a)		100496375 XM_002934481.2 XP_002934527.2
zebrafish (Danio rerio)	Actinopterygii	wdr35¹	WD repeat domain 35	71.63(n) 79.42(a)		565515 NM_001145589.1 NP_001139061.1
fruit fly (Drosophila melanogaster)	Insecta	Oseg4¹	Oseg4	54.3(n) 50.61(a)		38219 NM_001274349.1 NP_001261278.1
worm (Caenorhabditis elegans)	Secernentea	ifta-1¹	ifta-1	48.17(n) 34.7(a)		183817 NM_076539.3 NP_508940.3

ENSEMBL Gene Tree for WDR35 (if available)
TreeFam Gene Tree for WDR35 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for WDR35 gene

TULP2² TULP4² TUB² TULP1² TULP3²

1 SIMAP similar gene for WDR35 using alignment to 5 protein entries: WDR35_HUMAN (see all proteins):

DKFZp762F1313

Find genes that share paralogs with WDR35 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_065955⁴		Short rib-polydactyly syndrome 5 (SRPS5)⁴	--	see VAR_065955	2	W R	mis⁴		0	--	--	--	--
VAR_064581⁴		Cranioectodermal dysplasia 2 (CED2)⁴	--	see VAR_064581	2	E G	mis⁴		0	--	--	--	--
VAR_064582⁴		Cranioectodermal dysplasia 2 (CED2)⁴	--	see VAR_064582	2	A T	mis⁴		0	--	--	--	--
rs67421990^1,2	C	--	19936840(+)	`CCCCT-/ACACACA`	2	--	int¹		1		NA	2
rs201714582^1,2	C	--	20050503(+)	`TATTC-/AAAAAA`	2	--	ds500¹		0	--	--	--	--
rs186603271^1,2		--	20050699(+)	`CCTTCA/GTTCCT`	2	--	ds500¹		0	--	--	--	--
rs191564970^1,2		--	20050803(+)	`TTCCCC/TCCTTG`	2	--	ds500¹		0	--	--	--	--
rs142298200^1,2		--	20050938(+)	`ACACCA/GTGTTC`	2	--	ds500¹		0	--	--	--	--
rs113280329^1,2	C	--	20051015(+)	`TTTTCG/ATATTT`	2	--	ut3¹		2		CSA WA	120
rs182904051^1,2	C	--	20051027(+)	`TTCACC/TTAATA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for WDR35 (20110021 - 20189892 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for WDR35: About this table

Variant ID	Type	Subtype	PubMed ID
esv273450	CNV	Insertion	20981092
esv29979	CNV	Loss	17803354
nsv521619	CNV	Loss	19592680
dgv4067n71	CNV	Gain	21882294
nsv873715	CNV	Gain	21882294
nsv873714	CNV	Gain	21882294
nsv527453	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): WDR35

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing WDR35

DNA2.0 Custom Variant and Variant Library Synthesis for WDR35

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613602
OMIM disorders: 613610 614091
UniProtKB/Swiss-Prot: WDR35_HUMAN, Q9P2L0

Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and

ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow

thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus

with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely

spaced, hypoplastic and fused teeth. Note=The disease is caused by mutations affecting the gene represented in

this entry

Short rib-polydactyly syndrome 5 (SRPS5) [MIM:614091]: A lethal skeletal dysplasia characterized by

markedly short ribs, short limbs, polydactyly, narrow thorax, and multiple anomalies of major organs, including

heart, intestines, genitalia, kidney, liver, and pancreas. Additional SRPS5 hallmarks are acromesomelic

hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys. Note=The disease is

caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly

syndrome through impaired cilia formation. Primary fibroblasts from SRPS5 patients lacking WDR35 fail to produce

cilia (PubMed:21473986)

8 diseases for WDR35:
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short-rib thoracic dysplasia 7 with or without polydactyly cranioectodermal dysplasia 2 sensenbrenner syndrome short rib-polydactyly syndrome, type v

cranioectodermal dysplasia 1 asphyxiating thoracic dystrophy ellis-van creveld syndrome short-rib thoracic dysplasia 3 with or without polydactyly

4 inferred disease relationships from the University of Copenhagen DISEASES database for WDR35:

Sensenbrenner syndrome Polydactyly Asphyxiating thoracic dystrophy Ellis-Van Creveld syndrome

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for WDR35 gene, integrated from 10 sources (see all 20):
(articles sorted by number of sources associating them with WDR35)

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Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2, 3} Nagase T.... Ohara O. (DNA Res. 2000)
Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. (PubMed id 21473986)^{1, 2} Mill P.... Amor D.J. (Am. J. Hum. Genet. 2011)
Exome sequencing identifies WDR35 variants involved in Sensenbrenner syndrome. (PubMed id 20817137)^{1, 2} Gilissen C.... Brunner H.G. (Am. J. Hum. Genet. 2010)
Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis. (PubMed id 20193664)^{1, 2} Feng G.G....Ishikawa N. (Biochem. Biophys. Res. Commun. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (DNA Res. 2002)
Novel WDR35 mutations in patients with cranioectodermal dysplasia (Sensenbrenner syndrome). (PubMed id 22486404)¹ Hoffer J.L....Tzschach A. (Clin. Genet. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
WDR35 mutation in siblings with Sensenbrenner syndrome: a ciliopathy with variable phenotype. (PubMed id 22987818)¹ Bacino C.A....Bonnen P.E. (Am. J. Med. Genet. A 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57539	HGNC: 29250	AceView: WDR35	Ensembl:ENSG00000118965	euGenes: HUgn57539
ECgene: WDR35	H-InvDB: WDR35

(According to HUGE)
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HUGE: KIAA1336

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for WDR35	Pharmacogenomics, SNPs, Pathways

Intellectual Property for WDR35 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for WDR35 gene:
Search GeneIP for patents involving WDR35

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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WDR35 Gene

WD Repeat Domain 35

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