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Aliases for WDR35 Gene

Aliases for WDR35 Gene

  • WD Repeat Domain 35 2 3
  • Intraflagellar Transport Protein 121 Homolog 3 4
  • IFT121 3 4
  • KIAA1336 4
  • Naofen 3
  • IFTA1 3
  • SRTD7 3
  • CED2 3

External Ids for WDR35 Gene

Previous GeneCards Identifiers for WDR35 Gene

  • GC02M020097
  • GC02M020031
  • GC02M020110

Summaries for WDR35 Gene

Entrez Gene Summary for WDR35 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]

GeneCards Summary for WDR35 Gene

WDR35 (WD Repeat Domain 35) is a Protein Coding gene. Diseases associated with WDR35 include cranioectodermal dysplasia 2 and short-rib thoracic dysplasia 7 with or without polydactyly. Among its related pathways are Signaling by GPCR and Organelle biogenesis and maintenance. GO annotations related to this gene include binding. An important paralog of this gene is TUB.

UniProtKB/Swiss-Prot for WDR35 Gene

  • Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WDR35 Gene

Genomics for WDR35 Gene

Regulatory Elements for WDR35 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for WDR35 Gene

19,910,260 bp from pter
19,990,131 bp from pter
79,872 bases
Minus strand

Genomic View for WDR35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for WDR35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WDR35 Gene

Proteins for WDR35 Gene

  • Protein details for WDR35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    WD repeat-containing protein 35
    Protein Accession:
    Secondary Accessions:
    • B3KVI5
    • Q4ZG01
    • Q8NE11

    Protein attributes for WDR35 Gene

    1181 amino acids
    Molecular mass:
    133547 Da
    Quaternary structure:
    • Component of the IFT complex A (IFT-A). Interacts with IFT43.
    • Sequence=BAA92574.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for WDR35 Gene


neXtProt entry for WDR35 Gene

Proteomics data for WDR35 Gene at MOPED

Post-translational modifications for WDR35 Gene

  • Ubiquitination at Lys 776 and Lys 815
  • Modification sites at PhosphoSitePlus

Other Protein References for WDR35 Gene

Antibody Products

No data available for DME Specific Peptides for WDR35 Gene

Domains & Families for WDR35 Gene

Protein Domains for WDR35 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 WD repeats.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with WDR35: view

Function for WDR35 Gene

Molecular function for WDR35 Gene

UniProtKB/Swiss-Prot Function:
Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.
UniProtKB/Swiss-Prot Induction:

Gene Ontology (GO) - Molecular Function for WDR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with WDR35: view
genes like me logo Genes that share phenotypes with WDR35: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for WDR35 Gene

Localization for WDR35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for WDR35 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.

Subcellular locations from

Jensen Localization Image for WDR35 Gene COMPARTMENTS Subcellular localization image for WDR35 gene
Compartment Confidence
cytoskeleton 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for WDR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome ISS --
GO:0005929 cilium IBA --
GO:0005930 axoneme ISS --
GO:0030991 intraciliary transport particle A IDA 20889716
GO:0036064 ciliary basal body ISS --
genes like me logo Genes that share ontologies with WDR35: view

Pathways & Interactions for WDR35 Gene

genes like me logo Genes that share pathways with WDR35: view

Interacting Proteins for WDR35 Gene

Gene Ontology (GO) - Biological Process for WDR35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0035721 intraciliary retrograde transport IMP 20889716
GO:0042384 cilium assembly IMP 21473986
GO:0061512 protein localization to cilium IBA --
genes like me logo Genes that share ontologies with WDR35: view

No data available for SIGNOR curated interactions for WDR35 Gene

Drugs & Compounds for WDR35 Gene

No Compound Related Data Available

Transcripts for WDR35 Gene

Unigene Clusters for WDR35 Gene

WD repeat domain 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for WDR35 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: - -
SP3: - - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP3: - - -

Relevant External Links for WDR35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WDR35 Gene

mRNA expression in normal human tissues for WDR35 Gene

Protein differential expression in normal tissues from HIPED for WDR35 Gene

This gene is overexpressed in Testis (48.1) and Ovary (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for WDR35 Gene

SOURCE GeneReport for Unigene cluster for WDR35 Gene Hs.205427

genes like me logo Genes that share expression patterns with WDR35: view

Protein tissue co-expression partners for WDR35 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for WDR35 Gene

Orthologs for WDR35 Gene

This gene was present in the common ancestor of animals.

Orthologs for WDR35 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia WDR35 35
  • 88.82 (n)
  • 89.7 (a)
(Canis familiaris)
Mammalia WDR35 35
  • 91.42 (n)
  • 94.16 (a)
WDR35 36
  • 93 (a)
(Mus musculus)
Mammalia Wdr35 35
  • 86.72 (n)
  • 92.37 (a)
Wdr35 16
Wdr35 36
  • 92 (a)
(Pan troglodytes)
Mammalia WDR35 35
  • 99.49 (n)
  • 99.49 (a)
WDR35 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Wdr35l 35
  • 85.91 (n)
  • 92.73 (a)
(Monodelphis domestica)
Mammalia WDR35 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
-- 36
  • 90 (a)
-- 36
  • 88 (a)
-- 36
  • 89 (a)
(Gallus gallus)
Aves WDR35 35
  • 80.79 (n)
  • 86.04 (a)
WDR35 36
  • 86 (a)
(Anolis carolinensis)
Reptilia WDR35 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr35 35
  • 75.84 (n)
  • 82.9 (a)
(Danio rerio)
Actinopterygii wdr35 35
  • 71.63 (n)
  • 79.42 (a)
wdr35 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011562 35
  • 52.44 (n)
  • 50.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Oseg4 35
  • 54.3 (n)
  • 50.61 (a)
Oseg4 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea ifta-1 35
  • 48.17 (n)
  • 34.7 (a)
ifta-1 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5919 36
  • 60 (a)
Species with no ortholog for WDR35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WDR35 Gene

Gene Tree for WDR35 (if available)
Gene Tree for WDR35 (if available)

Paralogs for WDR35 Gene

Paralogs for WDR35 Gene

(1) SIMAP similar genes for WDR35 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with WDR35: view

Variants for WDR35 Gene

Sequence variations from dbSNP and Humsavar for WDR35 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs736952 -- 19,944,210(+) AGACA(C/G)TGGGA intron-variant
rs893392 -- 19,944,551(+) ACCTG(A/T)CAAAT intron-variant
rs893393 -- 19,944,571(+) TGTTT(G/T)GTGGC intron-variant
rs957613 -- 19,912,701(+) CATAA(A/G)AAATG utr-variant-3-prime
rs957614 -- 19,913,035(+) GCCAT(C/T)GCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for WDR35 Gene

Variant ID Type Subtype PubMed ID
esv29979 CNV Loss 17803354
dgv4067n71 CNV Gain 21882294
nsv873714 CNV Gain 21882294
nsv873715 CNV Gain 21882294
nsv521619 CNV Loss 19592680
nsv527453 CNV Gain 19592680
esv273450 CNV Insertion 20981092

Variation tolerance for WDR35 Gene

Residual Variation Intolerance Score: 67.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.82; 94.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for WDR35 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WDR35 Gene

Disorders for WDR35 Gene

MalaCards: The human disease database

(8) MalaCards diseases for WDR35 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cranioectodermal dysplasia 2
  • ced2
short-rib thoracic dysplasia 7 with or without polydactyly
  • short rib-polydactyly syndrome, type v
camurati engelmann disease, type 2
  • cranioectodermal dysplasia 2
cranioectodermal dysplasia 1
  • sensenbrenner syndrome
short-rib thoracic dysplasia 3 with or without polydactyly
  • saldino-noonan syndrome
- elite association
Search WDR35 in MalaCards View complete list of genes associated with diseases


  • Cranioectodermal dysplasia 2 (CED2) [MIM:613610]: A disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include short stature, dolichocephaly, craniosynostosis, narrow thorax with pectus excavatum, short limbs, brachydactyly, joint laxity, narrow palpebral fissures, telecanthus with hypertelorism, low-set simple ears, everted lower lip, and short neck. Teeth abnormalities include widely spaced, hypoplastic and fused teeth. {ECO:0000269 PubMed:20817137}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Short-rib thoracic dysplasia 7 with or without polydactyly (SRTD7) [MIM:614091]: A form of short-rib thoracic dysplasia, a group of autosomal recessive ciliopathies that are characterized by a constricted thoracic cage, short ribs, shortened tubular bones, and a trident appearance of the acetabular roof. Polydactyly is variably present. Non-skeletal involvement can include cleft lip/palate as well as anomalies of major organs such as the brain, eye, heart, kidneys, liver, pancreas, intestines, and genitalia. Some forms of the disease are lethal in the neonatal period due to respiratory insufficiency secondary to a severely restricted thoracic cage, whereas others are compatible with life. Disease spectrum encompasses Ellis-van Creveld syndrome, asphyxiating thoracic dystrophy (Jeune syndrome), Mainzer-Saldino syndrome, and short rib-polydactyly syndrome. SRTD7 hallmarks are acromesomelic hypomineralization, campomelia, polysyndactyly, laterality defects, and cystic kidneys. {ECO:0000269 PubMed:21473986}. Note=The disease is caused by mutations affecting the gene represented in this entry. WDR35 mutations cause short rib-polydactyly syndrome through impaired cilia formation. Primary fibroblasts from SRTD7 patients lacking WDR35 fail to produce cilia (PubMed:21473986). {ECO:0000269 PubMed:21473986}.

Relevant External Links for WDR35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with WDR35: view

No data available for Genatlas for WDR35 Gene

Publications for WDR35 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 67
  5. Novel WDR35 mutations in patients with cranioectodermal dysplasia (Sensenbrenner syndrome). (PMID: 22486404) Hoffer J.L. … Tzschach A. (Clin. Genet. 2013) 67

Products for WDR35 Gene

Sources for WDR35 Gene

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