Aliases for WDR34 Gene
External Ids for WDR34 Gene
Previous GeneCards Identifiers for WDR34 Gene
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Defects in this gene are a cause of short-rib thoracic dysplasia 11 with or without polydactyly. [provided by RefSeq, Mar 2014]
GeneCards Summary for WDR34 Gene
WDR34 (WD Repeat Domain 34) is a Protein Coding gene. Diseases associated with WDR34 include Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly and Asphyxiating Thoracic Dystrophy. Among its related pathways are Intraflagellar transport and Organelle biogenesis and maintenance. An important paralog of this gene is DYNC1I1.
UniProtKB/Swiss-Prot for WDR34 Gene
Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at Thr-184 and Thr-187 upon Il-1 beta stimulation.