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WDR34 Gene

protein-coding GIFtS: 44

GC09M130435

WD repeat domain 34
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC20486 ^¹, ²
OTTHUMP00000022282 ^²
RP11-216B9.5 ^²
bA216B9.3 ^¹, ²

Descriptions
WD repeat domain 34 ^²

External Ids
HGNC: 28296¹
Entrez Gene: 89891²
UniProtKB: Q96EX3³
Ensembl: ENSG00000119333⁷

Search outside databases for aliases for WDR34 gene

Previous GC identifers: GC09M126772 GC09M128475

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for WDR34:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved

regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which

may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are

involved in a variety of cellular processes, including cell cycle progression, signal

transduction, apoptosis, and gene regulation. [provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the WDR34 gene

Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.13

WDR34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M130435: (about GC identifiers)

Start:	130,435,761 bp from pter
End:	130,458,950 bp from pter
Size:	23,190 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3 (See protein sequence)

Recommended Name: WD repeat-containing protein 34

Size: 536 amino acids; 57801 Da

Secondary accessions: Q5VXV4 Q9BV46

REFSEQ proteins: NP_443076.2

ENSEMBL proteins:

ENSP00000361800

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (WDR34)
	Human Recombinant Proteins from Abnova (WDR34)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for WDR34:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (WDR34), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (WDR34)
	Novus Biologicals Antibody for WDR34

Assays for WDR34:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96EX3

ProtoNet protein and cluster: Q96EX3

UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3

Similarity: Contains 5 WD repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR34)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052844

Applied Biosystems Silencer® siRNAs for WDR34

Sigma-Aldrich siRNA for WDR34

Sigma-Aldrich shRNA for WDR34

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for WDR34
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_052844
Myc/DDK tagged cDNA clone in CMV expression vector: NM_052844
untagged cDNA clones in CMV expression vector (see all 2): NM_052844

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_052844

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for WDR34

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (WDR34)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_052844

Sigma-Aldrich siRNA for WDR34

Sigma-Aldrich shRNA for WDR34

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_052844

REFSEQ mRNAs for WDR34 gene:

NM_052844.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_052844

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_052844
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_052844
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_052844

Additional cDNA sequence:

AK302098.1 BC001614.1 BC011874.2 CR591297.1 CR591802.1 CR594160.1 CR594244.1 CR596639.1

CR601726.1 CR604643.1 CR605290.1 CR605861.1 CR607681.1 CR611062.1 CR613767.1 CR614951.1

CR615609.1 CR616487.1 CR618259.1 CR618445.1 CR618791.1 CR621430.1 CR625055.1 CR626799.1

24/34 DOTS entries (see all 34 ):

DT.315083 DT.100847609 DT.100847619 DT.100649581 DT.101970090 DT.100847610 DT.75122514 DT.100847612

DT.100847608 DT.75198478 DT.100847603 DT.100847622 DT.92452531 DT.75100454 DT.121201303 DT.121201304

DT.92452529 DT.97776651 DT.100847599 DT.100847623 DT.121201387 DT.97862136 DT.100847607 DT.100847620

24/571 AceView cDNA sequences (see all 571 ):

AA595541 CR626799 AI433652 CR605290 CR618259 CR596639 CA432295 AW067997

CR621430 CR625055 CR613767 CR618445 CR591802 AI611359 CR591297 BM008530

AI954975 BE881379 CR618791 AA329499 BI259718 AI473608 AI522032 AW249989

highest scoring ESTs for WDR34:

AL530779 AL558490 AW246269 AW409728 BC001614 BC011874 BE207272 BE208592 BE257557 BE264914

Unigene Cluster for WDR34:

WD repeat domain 34

Hs.495240 [show with all ESTs]

Unigene Representative Sequence: BM479044

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for WDR34 (see all 14 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	·	7c	^	8a	·	8b	·
SP1:																			-						-		-		-				-		-
SP2:																			-						-		-		-				-		-		-
SP3:																			-						-		-		-				-		-		-
SP4:																			-						-		-		-		-		-		-
SP5:																			-						-		-		-		-		-		-

ExUns:	8c	^	9
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for WDR34

1 Ensembl transcript including schematic representation:

ENST00000372715

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

WDR34 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for WDR34

¹ / ² / ³

4 probe-sets matching WDR34 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64504_r_at²^{, 3}	U95-C	1	1.00	1.00	0.99	0.92	AA868136	0.60	0.75	0.68	1
55028_at²^{, 3}	U95-B	1	1.00	1.00	0.98	1.08	AI954975	0.60	1.00	0.82	1
224715_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BG338983	0.60	1.00	0.82	1
224715_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks WDR34 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCAGGCCC

SOURCE GeneReport for Unigene cluster: Hs.495240

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for WDR34 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	WDR34¹	--	WD repeat domain 34	86.42(n) 87.66(a)	491314 XM_548435.2 XP_548435.2
chimpanzee (Pan troglodytes)	WDR34¹	--	WD repeat domain 34	99(n) 98.69(a)	464772 XM_001160437.1 XP_001160437.1
cow (Bos taurus)	WDR34¹	--	WD repeat domain 34	85.07(n) 84.14(a)	531489 XM_867009.2 XP_872102.1
rat (Rattus norvegicus)	Wdr34¹	--	WD repeat domain 34	83.49(n) 86.12(a)	296618 NM_001005542.1 NP_001005542.1
mouse (Mus musculus)	Wdr34^{1, 5}	2⁵	WD repeat domain 34^{1, 5}	81.46(n)¹ 83.15(a)¹	71820¹ NM_001008498.2¹ NP_001008498.2¹ AK014304⁵ AL928926⁵ (see all 8)

About this table Species with no ortholog for WDR34

ENSEMBL Gene Tree for WDR34

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for WDR34 gene

DNAI1² WDR78²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/138 NCBI SNPs in WDR34 are shown (see all 138 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2298038^1,2	C,F,H	130459243(-)	`GTGGCG/ACGGTT`	1	--	ng3¹		9		EA EU WA	2310
--	rs4837292^1,2	C	130458649(+)	`CTCCCA/CGCGGA`	1	W/G	mis¹ ese³		0	--	--	--	--
	rs4837291^1,2	A,C,F,H	130437300(+)	`CCGTCA/GGTGGC`	1	T/T	syn¹		9		MN NA EU EA WA	701
	rs2298045^1,2	A,C,F,H	130442917(-)	`CAGTAC/TGACAT`	1	Y/Y	syn¹		8		EA EU WA NA	2048
--	rs10760570^1,2	A,C,F,H	130438457(+)	`GACGGT/CTGCTG`	1	Q/Q	syn¹		6		NA MN EU WA	538
	rs945836^1,2	A,C,F,H	130440886(+)	`gggaaC/Tagccc`	1	--	int¹		7		EU EA WA NA	560
	rs7027823^1,2	A,C,F,H	130447876(+)	`ggctgA/Cagcca`	1	--	int¹		8		EU EA WA	826
--	rs7862967^1,2	A,C,F,H	130456422(+)	`GGTTCG/ATGCAG`	1	--	int¹		4		EU EA WA	418
	rs7037051^1,2	A,C,F,H	130449990(+)	`GGGACC/GCTCTG`	1	--	int¹		4		EU EA WA	418
	rs10819425^1,2	A,F,H	130453706(+)	`GAGGCC/TGAGGA`	1	--	int¹		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for WDR34 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for WDR34 gene:

DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 89891	HGNC: 28296	AceView: WDR34	Ensembl:ENSG00000119333	euGenes: HUgn89891
ECgene: WDR34	H-InvDB: WDR34

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for WDR34
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for WDR34:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for WDR34-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for WDR34		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for WDR34		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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WDR34 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for WDR34

Summaries
for WDR34

Genomic Location
for WDR34

Proteins
for WDR34

Protein Domains/
Families
for WDR34

Gene Function
for WDR34

Pathways & Interactions
for WDR34

Drugs & Compounds
for WDR34

Transcripts
for WDR34

Expression
for WDR34

Orthologs
for WDR34

Paralogs
for WDR34

SNPs/Variants
for WDR34

Disorders & Mutations
for WDR34

Medical News
for WDR34

Publications
for WDR34

Search for WDR34

Genome Databases showing WDR34

Other Databases showing WDR34

Specialized Databases showing WDR34

Licensable Technologies
for WDR34

Services
for WDR34

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

WDR34 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor WDR34

Summariesfor WDR34

Genomic Locationfor WDR34

Proteinsfor WDR34

Protein Domains/Familiesfor WDR34

Gene Functionfor WDR34

Pathways & Interactionsfor WDR34

Drugs & Compoundsfor WDR34

Transcriptsfor WDR34

Expression for WDR34

Orthologsfor WDR34

Paralogsfor WDR34

SNPs/Variantsfor WDR34

Disorders & Mutationsfor WDR34

Medical Newsfor WDR34

Publicationsfor WDR34

Search for WDR34

Genome Databases showing WDR34

Other Databases showing WDR34

Specialized Databases showing WDR34

Licensable Technologiesfor WDR34

Servicesfor WDR34

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for WDR34

Summaries
for WDR34

Genomic Location
for WDR34

Proteins
for WDR34

Protein Domains/
Families
for WDR34

Gene Function
for WDR34

Pathways & Interactions
for WDR34

Drugs & Compounds
for WDR34

Transcripts
for WDR34

Expression
for WDR34

Orthologs
for WDR34

Paralogs
for WDR34

SNPs/Variants
for WDR34

Disorders & Mutations
for WDR34

Medical News
for WDR34

Publications
for WDR34

Licensable Technologies
for WDR34

Services
for WDR34