WDR34 Gene
protein-coding GIFtS: 45
GCID: GC09M131395
|
|
WD repeat domain 34
| |
Aliases
for WDR34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| WD Repeat Domain 341 2 | | DIC51 2 | | BA216B9.31 | | MGC204861 | | WD Repeat-Containing Protein 342 |
Export aliases for WDR34 gene to outside databasesPrevious GC identifers: GC09M126772 GC09M128475 GC09M130435 GC09M101007 |
Summaries
for WDR34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for WDR34:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric ormultiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycleprogression, signal transduction, apoptosis, and gene regulation. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits theMAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1beta stimulation
|
Genomic Views
for WDR34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the WDR34 gene promoter:
AP-1 ATF-2 HSF1 (long) RelA NF-kappaB c-Rel HSF1short c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for WDR34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11WDR34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M131395: view genomic region
(about GC identifiers)
Start:
|
131,395,940 bp from pter |
End:
|
131,419,129 bp from pter |
Size:
|
23,190 bases |
Orientation:
|
minus strand |
|
Proteins
for WDR34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3 (See
protein sequence)Recommended Name: WD repeat-containing protein 34 Size: 536 amino acids; 57801 Da
Subunit: Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus).Interacts (via WD domains) with TRAF6 (via TRAF-type domains)
Subcellular location: Cytoplasm
Secondary accessions: Q5VXV4 Q9BV46Explore the universe of human proteins at neXtProt for WDR34: NX_Q96EX3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EX3
WDR34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443076.2
ENSEMBL proteins: ENSP00000361800 ENSP00000411370 ENSP00000415421
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
WDR34 for ontologies About GeneDecksing
WDR34 Antibody Products:
Assay Products for WDR34: |
Protein
Domains /
Families
for WDR34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
WDR34 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96EX3ProtoNet protein and cluster: Q96EX3 UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3Similarity: Contains 5 WD repeats |
Function
for WDR34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits theMAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1beta stimulation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR34 |
1 GenomeRNAi human phenotype for WDR34:
|
Pathways & Interactions
for WDR34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR34
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/6 Interacting proteins for WDR34 (Q96EX32, 3 ENSP000003618004) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for WDR34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for WDR34
Search CenterWatch for drugs/clinical trials and news about WDR34
|
Transcripts
for WDR34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for WDR34 gene: NM_052844.3 Unigene Cluster for WDR34: WD repeat domain 34 Hs.495240 [show with all ESTs]Unigene Representative Sequence: BM4790446 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372715(uc004bvq.1) ENST00000483181 ENST00000480613 ENST00000473486
ENST00000451652(uc011mbi.2) ENST00000419989
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: WDR34 (NM_052844) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for WDR34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat WDR34 |
Additional cDNA sequence: AK302098.1 BC001614.1 BC011874.2 24/32 DOTS entries (see all 32): DT.315083 DT.100649581 DT.100847609 DT.101970090 DT.100847619 DT.75122514 DT.100847610 DT.100847612 DT.100847608 DT.100847622 DT.75198478 DT.100847603 DT.92452531 DT.121201303 DT.121201304 DT.92452529 DT.97776651 DT.100847623 DT.121201387 DT.97862136 DT.100847599 DT.100847607 DT.100847620 DT.100847598 24/571 AceView cDNA sequences (see all 571): AA027965 AW498678 CD513122 CD672152 CR607681 CR591297 AW194678 CR618445 CR605290 CR615609 AI275203 CR621430 CR618791 AA595541 BM008530 AW249989 CR594244 CR601726 CR613767 CR618259 BX107069 AI611359 CR596639 CR616487
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for WDR34 (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | |
| ExUns: | 8c | ^ | 9 |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | | |
| SP5: | | | | |
ECgene alternative splicing isoforms for WDR34
|
Expression
for WDR34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| WDR34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAGGCCC
About this image
See WDR34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for WDR34
SOURCE GeneReport for Unigene cluster: Hs.495240
UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3Tissue specificity: Expressed in several cell lines (at protein level)
SABiosciences Custom PCR Arrays for WDR34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR34
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for WDR34 |
Orthologs
for WDR34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for WDR34 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for WDR34 (if available)
TreeFam Gene Tree for WDR34 (if available) |
Paralogs
for WDR34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for WDR34 gene
- WDR632 DNAI22 DYNC1I12 DNAI12 DYNC1I22 WDR782
WDR34 for paralogs About GeneDecksing
|
Genomic Variants
for WDR34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for WDR34 (131395940 - 131419129 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for WDR34
9 CNVs: 23886 100788 83191 96307 83192 83189 96308 70798 59509
3 Indels: 83190 96309 83193 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR34 |
|
Disorders
/ Diseases
for WDR34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 WDR34 for disorders About MalaCards
WDR34 for disorders About GeneDecksing
OMIM gene information: 613363
OMIM disorders: --
Export disorders for WDR34 gene to outside databases
|
Publications
for WDR34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for WDR34 gene integrated from 9 sources:
(articles sorted by number of sources associating them with WDR34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2, 3 Gao D....Chen D.Y. (2009)
- A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for WDR34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing WDR34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing WDR34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing WDR34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for WDR34 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for WDR34 gene:
Search GeneIP for patents involving WDR34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for WDR34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for WDR34 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for WDR34 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for WDR34 | | | OriGene Protein Over-expression Lysate for WDR34 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for WDR34 | | OriGene 3'-UTR Clone for WDR34 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for WDR34 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for WDR34 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat WDR34 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing WDR34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat WDR34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat WDR34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat WDR34 |
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