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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

WDR34 Gene

protein-coding   GIFtS: 45
GCID: GC09M131395

WD Repeat Domain 34

  Search for WDR34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
WD Repeat Domain 341 2
DIC52
bA216B9.32
WD Repeat-Containing Protein 342

External Ids:    HGNC: 282961   Entrez Gene: 898912   Ensembl: ENSG000001193337   OMIM: 6133635   UniProtKB: Q96EX33   

Export aliases for WDR34 gene to outside databases

Previous GC identifers: GC09M126772 GC09M128475 GC09M130435 GC09M101007


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for WDR34 Gene:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of
approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation
of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular
processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. (provided by
RefSeq, Jul 2008)

GeneCards Summary for WDR34 Gene: 
WDR34 (WD repeat domain 34) is a protein-coding gene. An important paralog of this gene is DNAI2.

UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the
MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon
Il-1 beta stimulation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the WDR34 gene promoter:
         AP-1   ATF-2   HSF1 (long)   RelA   NF-kappaB   c-Rel   HSF1short   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidWDR34 promoter sequence
   Search SABiosciences Chromatin IP Primers for WDR34

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat WDR34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.11

WDR34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
WDR34 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M131395:  view genomic region     (about GC identifiers)

Start:
131,395,940 bp from pter      End:
131,419,129 bp from pter
Size:
23,190 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3 (See protein sequence)
Recommended Name: WD repeat-containing protein 34  
Size: 536 amino acids; 57801 Da
Subunit: Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via
C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains)
Subcellular location: Cytoplasm
Secondary accessions: Q5VXV4 Q9BV46

Explore the universe of human proteins at neXtProt for WDR34: NX_Q96EX3

Explore proteomics data for WDR34 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96EX3

  • WDR34 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    WDR34 Protein Expression
    REFSEQ proteins: NP_443076.2  
    ENSEMBL proteins: 
     ENSP00000361800   ENSP00000411370   ENSP00000415421  

    Human Recombinant Protein Products for WDR34: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for WDR34 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    WDR34 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96EX3

    ProtoNet protein and cluster: Q96EX3

    UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3
    Similarity: Contains 5 WD repeats


    WDR34 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: WDR34_HUMAN, Q96EX3
    Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the
    MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon
    Il-1 beta stimulation

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    WDR34 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for WDR34:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for WDR34 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for WDR34

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/6 Interacting proteins for WDR34 (Q96EX32, 3 ENSP000003618004) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166592, 3MINT-8262176 I2D: score=2 
    MAP3K7O433183I2D: score=1 
    TAB2Q9NYJ83I2D: score=1 
    TAB3Q8N5C83I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for WDR34

    Search CenterWatch for drugs/clinical trials and news about WDR34

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for WDR34 gene: 
    NM_052844.3  

    Unigene Cluster for WDR34:

    WD repeat domain 34
    Hs.495240  [show with all ESTs]
    Unigene Representative Sequence: BM479044
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372715(uc004bvq.1) ENST00000483181 ENST00000480613 ENST00000473486
    ENST00000451652(uc011mbi.2) ENST00000419989
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AK302098.1 BC001614.1 BC011874.2 

    24/32 DOTS entries (see all 32):

    DT.315083  DT.100649581  DT.100847609  DT.101970090  DT.100847619  DT.75122514  DT.100847610  DT.100847612 
    DT.100847608  DT.100847622  DT.75198478  DT.100847603  DT.92452531  DT.121201303  DT.121201304  DT.92452529 
    DT.97776651  DT.100847623  DT.121201387  DT.97862136  DT.100847599  DT.100847607  DT.100847620  DT.100847598 

    24/571 AceView cDNA sequences (see all 571):

    AW002892 CR626799 AW498678 AW249989 BE881379 BI259718 AW067997 CR591802 
    AI954975 AI784435 AI275203 CR615609 AI784427 CA432295 CR611062 CR605290 
    AW194678 CR591297 CR607681 CD513122 CD672152 CR605861 BX097489 CR604643 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for WDR34 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8a · 8b ·
    SP1:                                                        -                 -     -     -           -     -                                                   
    SP2:                                                        -                 -     -     -           -     -     -                                             
    SP3:                                                        -                 -     -     -           -     -     -                                             
    SP4:                                                        -                 -     -     -     -     -     -                                                   
    SP5:                                                        -                 -     -     -     -     -     -                                                   

    ExUns: 8c ^ 9
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for WDR34

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    WDR34 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCAGGCCC
    WDR34 Expression
    About this image


    See WDR34 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for WDR34

    SOURCE GeneReport for Unigene cluster: Hs.495240

    UniProtKB/Swiss-Prot: WDR34_HUMAN, Q96EX3
    Tissue specificity: Expressed in several cell lines (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for WDR34 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Wdr341 , 5 WD repeat domain 341, 5 81.46(n)1
    83.15(a)1
      2 (21.04 cM)5
    718201  NM_001008498.21  NP_001008498.21 
     300315465 
    chicken
    (Gallus gallus)
    Aves WDR341 WD repeat domain 34 65.32(n)
    64.24(a)
      417211  XM_415494.3  XP_415494.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BG304270.12   -- 71.64(n)    BG304270.1 


    ENSEMBL Gene Tree for WDR34 (if available)
    TreeFam Gene Tree for WDR34 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for WDR34 gene
    DNAI22  DNAI12  DYNC1I12  DYNC1I22  WDR782  

    WDR34 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/596 SNPs in WDR34 are shown (see all 596)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465622251,2
    C,F--131396514(+) CCCAGA/GGGCAG 2 P S mis11Minor allele frequency- G:0.00NA 4524
    rs2000522391,2
    --131396527(+) GCAAAA/TACCAA 2 V syn10--------
    rs2017845481,2
    --131396550(+) GGACCA/GGCGCA 2 R W mis10--------
    rs2012022951,2
    --131396551(+) GACCAA/GCGCAC 2 R syn10--------
    rs1862364781,2
    C--131396567(+) ACAGAC/TACTTG 2 Y C mis10--------
    rs1468175841,2
    C--131396647(+) CCAGCG/ACTCAG 2 /S syn11Minor allele frequency- A:0.00NA 4538
    rs22980461,2
    C,F--131396771(-) GACCCG/AGGAGG 1 -- int11Minor allele frequency- A:0.02EA 120
    rs758504531,2
    C--131396795(+) TTGGTC/GCTCTC 1 -- int10--------
    rs557600031,2
    C,F--131396849(+) ACACGG/AGTCTC 1 -- int12Minor allele frequency- A:0.03WA 120
    rs562580871,2
    C--131397040(+) GGGCCC/TGCAGG 2 Q R mis10--------

    HapMap Linkage Disequilibrium report for WDR34 (131395940 - 131419129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for WDR34 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1002903CNV Deletion20482838
    esv2739075CNV Deletion23290073
    esv2677232CNV Deletion23128226
    nsv820577CNV Deletion20802225
    esv2436971CNV Deletion19546169
    esv1498928CNV Deletion17803354
    nsv825103CNV Loss20364138
    nsv825097CNV Loss20364138
    dgv1236n67CNV Loss20364138
    esv2591544CNV Loss19546169

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    WDR34 for disorders           About MalaCards
    OMIM gene information: 613363    OMIM disorders: --


    WDR34 for disorders           About GeneDecksing


    Export disorders for WDR34 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for WDR34 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with WDR34)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. WDR34 is a novel TAK1-associated suppressor of the IL -1R/TLR3/TLR4-induced NF-kappaB activation pathway. (PubMed id 19521662)1, 2, 3 Gao D....Chen D.Y. (2009)
    2. A unified taxonomy for ciliary dyneins. (PubMed id 21953912)1, 3 Hom E.F....King S.M. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (2013)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89891 HGNC: 28296 AceView: WDR34 Ensembl:ENSG00000119333 euGenes: HUgn89891
    ECgene: WDR34 H-InvDB: WDR34

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for WDR34 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for WDR34 gene:
    Search GeneIP for patents involving WDR34

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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